Works (3)
Updated: July 5th, 2023 15:43
2022 article
TCDD alters essential transcriptional regulators of osteogenic differentiation in multipotent mesenchymal stem cells
Watson, A. L. T. D., Carmona Baez, A., Jima, D., Reif, D., Ding, J., Roberts, R., & Kullman, S. W. (2022, November 12). TOXICOLOGICAL SCIENCES, Vol. 11.
author keywords: mesenchymal stem cell; AhR; cell differentiation
MeSH headings : Humans; Osteogenesis / genetics; Polychlorinated Dibenzodioxins / toxicity; Cell Differentiation; Fibroblast Growth Factors / metabolism; Mesenchymal Stem Cells / metabolism; Cells, Cultured; Osteoblasts
TL;DR:
A global transcriptomic landscape during early, intermediate, and apical stages of osteogenic differentiation in vitro in response to TCDD is established to identify novel pathways and transcription factors that may facilitate a better understanding of the osteoblast differentiation process, perturbation by exogenous agents, and potential intervention strategies targeting those specific pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 12, 2022
2016 journal article
From the Cover: Embryonic Exposure to TCDD Impacts Osteogenesis of the Axial Skeleton in Japanese medaka,Oryzias latipes
Toxicological Sciences, 155(2), 485–496.
Contributors: A. Watson, A. Planchart n , C. Mattingly n , C. Winkler *, D. Reif n & S. Kullman n
author keywords: receptor, aryl hydrocarbon; gene expression/regulation, bone; transgenic models; methods, developmental/teratology; reproductive and developmental toxicology
MeSH headings : Animals; Calcification, Physiologic / drug effects; Down-Regulation / drug effects; Microscopy, Confocal; Musculoskeletal Diseases / metabolism; Oryzias / embryology; Osteogenesis / drug effects; Polychlorinated Dibenzodioxins / toxicity; Real-Time Polymerase Chain Reaction; Skeleton / drug effects; Skeleton / metabolism; Trans-Activators / drug effects
TL;DR:
It is suggested that TCDD exposure inhibits axial bone formation through dysregulation of osteoblast differentiation.
(via Semantic Scholar)
open access via academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2014 journal article
Dynamic Selenium Assimilation, Distribution, Efflux, and Maternal Transfer in Japanese Medaka Fed a Diet of Se-enriched Mayflies
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 48(5), 2971–2978.
Contributors: J. Conley n, A. Watson n, L. Xie * & D. Buchwalter n
MeSH headings : Animals; Diet; Ephemeroptera / metabolism; Female; Food Chain; Gastrointestinal Tract / metabolism; Larva / metabolism; Liver / metabolism; Male; Oryzias / metabolism; Ovary / metabolism; Ovum / metabolism; Selenium / metabolism; Testis / metabolism; Tissue Distribution
TL;DR:
Interestingly, medaka appeared to rapidly shuttle Se to their eggs directly from their diet via the ovary, as opposed to mobilization from surrounding tissues, resulting in dynamic egg that was more attributable to recent dietary Se ingestion than female whole body Se ingestion in this asynchronous spawning fish.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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