Works (3)

Updated: July 5th, 2023 15:43

2022 article

TCDD alters essential transcriptional regulators of osteogenic differentiation in multipotent mesenchymal stem cells

Watson, A. L. T. D., Carmona Baez, A., Jima, D., Reif, D., Ding, J., Roberts, R., & Kullman, S. W. (2022, November 12). TOXICOLOGICAL SCIENCES, Vol. 11.

By: A. Watson n, A. Carmona Baez n, D. Jima n, D. Reif n, J. Ding*, R. Roberts n, S. Kullman n

author keywords: mesenchymal stem cell; AhR; cell differentiation
MeSH headings : Humans; Osteogenesis / genetics; Polychlorinated Dibenzodioxins / toxicity; Cell Differentiation; Fibroblast Growth Factors / metabolism; Mesenchymal Stem Cells / metabolism; Cells, Cultured; Osteoblasts
TL;DR: A global transcriptomic landscape during early, intermediate, and apical stages of osteogenic differentiation in vitro in response to TCDD is established to identify novel pathways and transcription factors that may facilitate a better understanding of the osteoblast differentiation process, perturbation by exogenous agents, and potential intervention strategies targeting those specific pathways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 12, 2022

2016 journal article

From the Cover: Embryonic Exposure to TCDD Impacts Osteogenesis of the Axial Skeleton in Japanese medaka,Oryzias latipes

Toxicological Sciences, 155(2), 485–496.

By: A. Watson*, A. Planchart n, C. Mattingly n, C. Winkler*, D. Reif n & S. Kullman n

Contributors: A. Watson, A. Planchart n, C. Mattingly n, C. Winkler*, D. Reif n & S. Kullman n

author keywords: receptor, aryl hydrocarbon; gene expression/regulation, bone; transgenic models; methods, developmental/teratology; reproductive and developmental toxicology
MeSH headings : Animals; Calcification, Physiologic / drug effects; Down-Regulation / drug effects; Microscopy, Confocal; Musculoskeletal Diseases / metabolism; Oryzias / embryology; Osteogenesis / drug effects; Polychlorinated Dibenzodioxins / toxicity; Real-Time Polymerase Chain Reaction; Skeleton / drug effects; Skeleton / metabolism; Trans-Activators / drug effects
TL;DR: It is suggested that TCDD exposure inhibits axial bone formation through dysregulation of osteoblast differentiation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Dynamic Selenium Assimilation, Distribution, Efflux, and Maternal Transfer in Japanese Medaka Fed a Diet of Se-enriched Mayflies


By: J. Conley n, A. Watson n, L. Xie* & D. Buchwalter n

MeSH headings : Animals; Diet; Ephemeroptera / metabolism; Female; Food Chain; Gastrointestinal Tract / metabolism; Larva / metabolism; Liver / metabolism; Male; Oryzias / metabolism; Ovary / metabolism; Ovum / metabolism; Selenium / metabolism; Testis / metabolism; Tissue Distribution
TL;DR: Interestingly, medaka appeared to rapidly shuttle Se to their eggs directly from their diet via the ovary, as opposed to mobilization from surrounding tissues, resulting in dynamic egg that was more attributable to recent dietary Se ingestion than female whole body Se ingestion in this asynchronous spawning fish. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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