@article{vidal_sosnowski_marchesoni_grenier_thorp_murphy_johnson_schlief_hoyo_2024, title={Maternal adverse childhood experiences (ACEs) and offspring imprinted gene DMR methylation at birth}, volume={19}, ISSN={["1559-2308"]}, DOI={10.1080/15592294.2023.2293412}, abstractNote={ABSTRACT Adverse childhood experiences (ACEs) contribute to numerous negative health outcomes across the life course and across generations. Here, we extend prior work by examining the association of maternal ACEs, and their interaction with financial stress and discrimination, with methylation status within eight differentially methylated regions (DMRs) in imprinted domains in newborns. ACEs, financial stress during pregnancy, and experience of discrimination were self-reported among 232 pregnant women. DNA methylation was assessed at PEG10/SGCE, NNAT, IGF2, H19, PLAGL1, PEG3, MEG3-IG, and DLK1/MEG3 regulatory sequences using pyrosequencing. Using multivariable linear regression models, we found evidence to suggest that financial stress was associated with hypermethylation of MEG3-IG in non-Hispanic White newborns; discrimination was associated with hypermethylation of IGF2 and NNAT in Hispanic newborns, and with hypomethylation of PEG3 in non-Hispanic Black newborns. We also found evidence that maternal ACEs interacted with discrimination to predict offspring PLAGL1 altered DMR methylation, in addition to interactions between maternal ACEs score and discrimination predicting H19 and SGCE/PEG10 altered methylation in non-Hispanic White newborns. However, these interactions were not statistically significant after multiple testing corrections. Findings from this study suggest that maternal ACEs, discrimination, and financial stress are associated with newborn aberrant methylation in imprinted gene regions.}, number={1}, journal={EPIGENETICS}, author={Vidal, Adriana C. and Sosnowski, David W. and Marchesoni, Joddy and Grenier, Carole and Thorp, John and Murphy, Susan K. and Johnson, Sara B. and Schlief, Billy and Hoyo, Cathrine}, year={2024}, month={Dec} }
 @article{vidal_chandramouli_marchesoni_brown_liu_murphy_maguire_wang_abdelmalek_mavis_et al._2023, title={<i>AHRR</i> Hypomethylation mediates the association between maternal smoking and metabolic profiles in children}, volume={7}, ISSN={["2471-254X"]}, DOI={10.1097/HC9.0000000000000243}, abstractNote={
            Background:
            Tobacco smoking during pregnancy is associated with metabolic dysfunction in children, but mechanistic insights remain limited. Hypomethylation of cg05575921 in the aryl hydrocarbon receptor repressor (AHRR) gene is associated with in utero tobacco smoke exposure. In this study, we evaluated whether AHRR hypomethylation mediates the association between maternal smoking and metabolic dysfunction in children.
          }, number={10}, journal={HEPATOLOGY COMMUNICATIONS}, author={Vidal, Adriana C. and Chandramouli, Shivram A. and Marchesoni, Joddy and Brown, Nia and Liu, Yukun and Murphy, Susan K. and Maguire, Rachel and Wang, Yaxu and Abdelmalek, Manal F. and Mavis, Alisha M. and et al.}, year={2023}, month={Oct} }
 @article{liu_gu_de hoedt_cooperberg_amling_kane_klaassen_terris_guerrios-rivera_vidal_et al._2023, title={Are associations between obesity and prostate cancer outcomes following radical prostatectomy the same in smokers and non-smokers? Results from the SEARCH Cohort}, ISSN={["1573-7225"]}, DOI={10.1007/s10552-023-01747-2}, journal={CANCER CAUSES & CONTROL}, author={Liu, Ivy T. and Gu, Lin and De Hoedt, Amanda M. and Cooperberg, Matthew R. and Amling, Christopher L. and Kane, Christopher J. and Klaassen, Zachary and Terris, Martha K. and Guerrios-Rivera, Lourdes and Vidal, Adriana C. and et al.}, year={2023}, month={Jul} }
 @article{pereira_oyekunle_janes_amling_aronson_cooperberg_kane_terris_klaassen_freedland_et al._2023, title={Time from biopsy to radical prostatectomy by race in an equal-access healthcare system: Results from the SEARCH cohort}, ISSN={["1097-0045"]}, DOI={10.1002/pros.24542}, abstractNote={Abstract}, journal={PROSTATE}, author={Pereira, Victor and Oyekunle, Taofik and Janes, Jessica and Amling, Christopher J. and Aronson, William J. and Cooperberg, Matthew R. and Kane, Christopher J. and Terris, Martha K. and Klaassen, Zachary and Freedland, Stephen J. and et al.}, year={2023}, month={Apr} }
 @misc{vidal_moylan_wilder_grant_murphy_hoyo_2022, title={Racial disparities in liver cancer: Evidence for a role of environmental contaminants and the epigenome}, volume={12}, ISSN={["2234-943X"]}, DOI={10.3389/fonc.2022.959852}, abstractNote={Liver cancer incidence has tripled since the early 1980s, making this disease one of the fastest rising types of cancer and the third leading cause of cancer-related deaths worldwide. In the US, incidence varies by geographic location and race, with the highest incidence in the southwestern and southeastern states and among racial minorities such as Hispanic and Black individuals. Prognosis is also poorer among these populations. The observed ethnic disparities do not fully reflect differences in the prevalence of risk factors, e.g., for cirrhosis that may progress to liver cancer or from genetic predisposition. Likely substantial contributors to risk are environmental factors, including chemical and non-chemical stressors; yet, the paucity of mechanistic insights impedes prevention efforts. Here, we review the current literature and evaluate challenges to reducing liver cancer disparities. We also discuss the hypothesis that epigenetic mediators may provide biomarkers for early detection to support interventions that reduce disparities.}, journal={FRONTIERS IN ONCOLOGY}, author={Vidal, Adriana C. C. and Moylan, Cynthia A. A. and Wilder, Julius and Grant, Delores J. J. and Murphy, Susan K. K. and Hoyo, Cathrine}, year={2022}, month={Aug} }