2021 journal article

A physiological model of the inflammatory-thermal-pain-cardiovascular interactions during an endotoxin challenge


By: A. Dobreva n, R. Brady-Nicholls*, K. Larripa*, C. Puelz*, J. Mehlsen* & M. Olufsen n

author keywords: cardiovascular dynamics; immune response; mathematical modelling; parameter estimation; thermal regulation
MeSH headings : Endotoxins / toxicity; Humans; Inflammation; Inflammation Mediators; Male; Pain; Sepsis
TL;DR: An innovative mathematical model incorporating interaction pathways between inflammation and physiological processes observed in response to an endotoxin challenge is developed and revealed that a multimodal treatment combining several therapeutic strategies gives the best recovery outcome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: March 8, 2021

2021 journal article

Data assimilation of synthetic data as a novel strategy for predicting disease progression in alopecia areata


By: N. Cogan*, F. Bao*, R. Paus* & A. Dobreva n

author keywords: personalized medicine; data assimilation; autoimmunity; alopecia areata
MeSH headings : Alopecia Areata / epidemiology; Autoimmune Diseases; Bayes Theorem; Disease Progression; Humans
TL;DR: This study applies a Bayesian data assimilation method to a model of the autoimmune disease alopecia areata that is characterized by distinct spatial patterns of hair loss, and finds that this method works better for sparse observations, sensitive parameters and noisy observations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: September 20, 2021

2020 journal article

Toward Predicting the Spatio-Temporal Dynamics of Alopecia Areata Lesions Using Partial Differential Equation Analysis


By: A. Dobreva n, R. Paus* & N. Cogan*

author keywords: Partial differential equations (PDEs); Alopecia areata; Autoimmunity; Hair loss
MeSH headings : Alopecia Areata / etiology; Alopecia Areata / immunology; Alopecia Areata / pathology; Animals; Autoimmune Diseases / etiology; Autoimmune Diseases / immunology; Autoimmune Diseases / pathology; Computer Simulation; Cytokines / immunology; Disease Models, Animal; Hair Follicle / immunology; Hair Follicle / pathology; Humans; Interferon-gamma / immunology; Linear Models; Mathematical Concepts; Mice; Models, Biological; Spatio-Temporal Analysis; T-Lymphocytes / immunology
TL;DR: A model of partial differential equations (PDEs) is developed to describe the spatio-temporal dynamics of immune system components that clinical and experimental studies show are primarily involved in the disease development of alopecia areata. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 30, 2020

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