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Works (28)
Updated: June 27th, 2024 05:01
2024 journal article
A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD plus precursor combination
SCIENTIFIC REPORTS, 14(1).
author keywords: Aging; Senolytic; NAD plus; Canine cognitive dysfunction syndrome; Cognitive impairment; Longevity
open access via www.nature.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 24, 2024
2023 journal article
A novel task of canine olfaction for use in adult and senior pet dogs
SCIENTIFIC REPORTS, 13(1).
MeSH headings : Dogs; Animals; Smell; Food; Aging; Neuropsychological Tests
TL;DR:
A novel olfaction test using spontaneous search behavior in dogs to find a hidden food treat in a three-choice task with both light-phase and dark-phase conditions is described, making it feasible to compare between and within groups of pet dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 19, 2023
2023 journal article
Activity patterns are associated with fractional lifespan, memory, and gait speed in aged dogs
SCIENTIFIC REPORTS, 13(1).
MeSH headings : Humans; Dogs; Animals; Alzheimer Disease; Longevity; Walking Speed; Gait; Cognition; Cognitive Dysfunction; Aging / psychology; Pain
TL;DR:
It is found that activity patterns in dogs are associated with fractional lifespan and working memory, and dogs with higher on/off leash gait speed are more active in the afternoon of weekdays.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 19, 2023
2023 journal article
Longitudinal Analysis of Canine Oral Microbiome Using Whole Genome Sequencing in Aging Companion Dogs
ANIMALS, 13(24).
author keywords: oral; microbiome; canine cognitive dysfunction syndrome; Alzheimer's disease
TL;DR:
The importance of defining the oral microbiota in aged dogs with a view to understanding potential therapeutic targets is shown, with an increased fungal and bacterial alpha diversity in aging dogs over time and nearly universal oral dysbiosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 16, 2024
2023 journal article
Relationship between engagement with the impossible task, cognitive testing, and cognitive questionnaires in a population of aging dogs
FRONTIERS IN VETERINARY SCIENCE, 9.
author keywords: canine cognitive dysfunction syndrome; canine cognition; frustration; aging; dogs
TL;DR:
The high correlation with several cognitive measures and the ease of administration of this test makes it a useful tool in evaluating canine cognitive dysfunction syndrome, however it is unclear if increased frustration or other cognitive processes are contributing to the observed changes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023
2023 journal article
Winning the race with aging: age-related changes in gait speed and its association with cognitive performance in dogs
FRONTIERS IN VETERINARY SCIENCE, 10.
author keywords: canine cognitive dysfunction syndrome; canine gerontology; mobility; walking speed; memory; attention
TL;DR:
Dogs' food-motivated gait speed off leash is correlated with fractional lifespan and cognitive performance in dogs, particularly in the domains of attention and working memory and proves to be a more effective indicator of age-related deterioration and cognitive decline than gaitspeed on leash.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 24, 2023
2022 journal article
A Pilot, Open-Label Study to Evaluate the Efficacy of Intra-Articular Administration of a Caninized TNF Receptor Fc Fusion Protein as a Treatment for Osteoarthritis-Associated Joint Pain
FRONTIERS IN VETERINARY SCIENCE, 9.
author keywords: osteoarthritis; joint pain; TNF-alpha; force plate; limb use asymmetry test
TL;DR:
The IA injection of caTNFR-Fc fusion protein provided no benefit in terms of objective limb use and activity data in dogs with OA in this pilot study, and data indicate TNF-α may not be a good therapeutic target in canine OA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 27, 2022
2022 article
Relationship between hearing, cognitive function, and quality of life in aging companion dogs
Fefer, G., Khan, M. Z., Panek, W. K., Case, B., Gruen, M. E., & Olby, N. J. (2022, August 6). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 8.
author keywords: canine cognitive dysfunction syndrome; CCDS; cognitive testing; dementia; presbycusis
MeSH headings : Aging; Animals; Cognition; Dementia / epidemiology; Dog Diseases; Dogs; Hearing; Humans; Pets; Presbycusis / epidemiology; Presbycusis / veterinary; Prospective Studies; Quality of Life
TL;DR:
Presbycusis negatively alters owner‐pet interactions and is associated with poor executive performance and owner‐assessed dementia severity, and in multivariate analysis, higher CADES score was associated with worse hearing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 22, 2022
2022 journal article
Use of Cognitive Testing, Questionnaires, and Plasma Biomarkers to Quantify Cognitive Impairment in an Aging Pet Dog Population
JOURNAL OF ALZHEIMERS DISEASE, 87(3), 1367–1378.
author keywords: Blood biomarkers; canine cognitive dysfunction syndrome; CCDS; cognitive testing; dementia; neurofilament light chain; NfL
TL;DR:
It is suggested that a multi-dimensional approach using a combination of questionnaires, specific cognitive tests, and pNfL concentration can be used to quantify cognitive decline in aging pet dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 20, 2022
2021 journal article
Sustained Gaze Is a Reliable In-home Test of Attention for Aging Pet Dogs
FRONTIERS IN VETERINARY SCIENCE, 8.
author keywords: Canine Cognitive Dysfunction Syndrome; cognitive testing; dementia; executive function; attention; cognitive impairment
TL;DR:
It is concluded that owners can perform the sustained gaze test at home and that data generated are reliable and correlate to CADES, a validated measure of dementia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 24, 2022
2020 journal article
Evaluation of repeated dosing of a dexmedetomidine oromucosal gel for treatment of noise aversion in dogs over a series of noise events
VETERINARY RECORD, 187(12).
MeSH headings : Animals; Anti-Anxiety Agents / administration & dosage; Anti-Anxiety Agents / therapeutic use; Anxiety / drug therapy; Behavior, Animal / drug effects; Cost of Illness; Dexmedetomidine / administration & dosage; Dexmedetomidine / therapeutic use; Dogs / psychology; Fear / drug effects; Female; Gels; Humans; Male; Noise / adverse effects; Surveys and Questionnaires
TL;DR:
Repeated use of dexmedetomidine gel for noise events resulted in decreased need for administration and overall burden of care was manageable, yet many owners agreed with statements regarding frustration, stress, guilt, guilt and sadness about their dog’s condition.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 30, 2020
2016 journal article
Evaluation of Clinical Metrology Instrument in Dogs with Osteoarthritis
Journal of Veterinary Internal Medicine, 30(3), 836–846.
author keywords: Analgesia; Client metrology instrument; Degenerative joint disease; Questionnaire
MeSH headings : Animals; Antibodies / immunology; Antibodies / therapeutic use; Dog Diseases / immunology; Dog Diseases / physiopathology; Dog Diseases / therapy; Dogs; Double-Blind Method; Immunotherapy / veterinary; Nerve Growth Factor / immunology; Osteoarthritis / physiopathology; Osteoarthritis / therapy; Osteoarthritis / veterinary; Pain / drug therapy; Pain / veterinary; Pain Measurement / veterinary; Pilot Projects; Proof of Concept Study
TL;DR:
There is little difference between independent and dependent interviewing, however, dependent interviewing resulted in increased treatment effect sizes and investigators could increase clinical trial power through minimal change to study design.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Widespread somatosensory sensitivity in naturally occurring canine model of osteoarthritis
PAIN, 157(6), 1325–1332.
Contributors: D. Knazovicky n , E. Helgeson n, n, M. Gruen n , W. Maixner n & B. Lascelles n
author keywords: Animal model; Osteoarthritis; Spontaneous osteoarthritis model; Quantitative sensory testing
MeSH headings : Animals; Arthralgia / physiopathology; Arthralgia / veterinary; Central Nervous System Sensitization / physiology; Dogs; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain Measurement; Pain Threshold / physiology; Physical Stimulation; Sensory Thresholds / physiology
TL;DR:
The canine spontaneous OA model is associated with somatosensory sensitivity, likely indicative of central sensitization in human patients' chronic pain, and is validated as an appropriate model of the human OA pain condition.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
A canine-specific anti-nerve growth factor antibody alleviates pain and improves mobility and function in dogs with degenerative joint disease-associated pain
BMC VETERINARY RESEARCH, 11(1).
Contributors: B. Lascelles n, D. Knazovicky n , n, M. Freire *, J. Innes, A. Drew*, D. Gearing*
author keywords: Nerve growth factor; Dog; Antibody; Pain; Model; Osteoarthritis; Accelerometry; Actimetry
MeSH headings : Animals; Antibodies / immunology; Antibodies / therapeutic use; Dog Diseases / therapy; Dogs; Double-Blind Method; Female; Immunotherapy / veterinary; Male; Nerve Growth Factor / immunology; Osteoarthritis / therapy; Osteoarthritis / veterinary; Pain / drug therapy; Pain / veterinary
TL;DR:
These pilot data demonstrate a positive analgesic effect of anti-NGF antibody in dogs suffering from chronic pain, similar to that expected with an NSAID.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
A test for the evaluation of emotional reactivity in Labrador retrievers used for explosives detection
JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH, 10(2), 94–102.
author keywords: emotional reactivity test; anxiety scores; selection criteria; behavioral screening; explosives detection dog
TL;DR:
It is concluded that the ERT is a useful pre-training screening test that can be used to identify dogs with a low threshold of emotional reactivity for rejection, anddogs with a high threshold of emotions for entry into the IDD training program.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
The use of an open-field model to assess sound-induced fear and anxiety-associated behaviors in Labrador retrievers
JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH, 10(4), 338–345.
author keywords: military working dogs; open-field test; fear; anxiety; thunderstorm; gunfire
TL;DR:
In general, candidate IED-detection Labrador retrievers responded to sound stimuli and recovered quickly, although dogs stratified in their response to sound stimulus, suggesting that dogs habituated to the open field arena.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Use of oral trazodone for sedation in cats: a pilot study
JOURNAL OF FELINE MEDICINE AND SURGERY, 18(6), 476–482.
MeSH headings : Accelerometry / veterinary; Administration, Oral; Animals; Anti-Anxiety Agents / administration & dosage; Behavior, Animal / drug effects; Cats / physiology; Male; Pilot Projects; Trazodone / administration & dosage; Treatment Outcome
TL;DR:
Trazodone was well tolerated in this population of cats and caused appreciable sedation at all doses and further studies are recommended to investigate the use of oral trazodone in cats for the purpose of decreasing anxiety assocaited with transportation and examination.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Acquisition of a visual discrimination and reversal learning task by Labrador retrievers
ANIMAL COGNITION, 17(3), 787–792.
author keywords: Dog; Canine; Cognition; Visual discrimination
MeSH headings : Animals; Cognition; Discrimination Learning; Discrimination, Psychological; Dogs / psychology; Female; Male; Neuropsychological Tests; Pattern Recognition, Visual; Reversal Learning; Visual Perception
TL;DR:
The present study confirmed that the modified TGTA system is suitable for cognitive evaluations in Labrador retriever MWDs and can be used to further explore effects of sex, phenotype, age, and other factors in relation to canine cognition and learning, and may provide an additional screening tool for MWD selection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Thermal dose fractionation affects tumour physiological response
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 28(5), 431–440.
author keywords: thermal dosimetry; tumor oxygenation; microenvironment
MeSH headings : Animals; Antigens, Neoplasm / metabolism; Carbonic Anhydrases / metabolism; Caspase 3 / metabolism; Dogs; Hyperthermia, Induced; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Sarcoma / metabolism; Sarcoma / pathology; Sarcoma / therapy; Soft Tissue Neoplasms / metabolism; Soft Tissue Neoplasms / pathology; Soft Tissue Neoplasms / therapy; Tumor Burden; Vascular Endothelial Growth Factor A / metabolism
TL;DR:
There was a greater reduction in tumour volume and water diffusion at the end of therapy in tumours receiving one hyperthermia fraction per week, and response data pointed to a one per week prescription being superior.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Changes in tumour oxygenation during fractionated hyperthermia and radiation therapy in spontaneous canine sarcomas
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 22(5), 365–373.
author keywords: hyperthermia; radiation therapy; dog; oxygen measurements
MeSH headings : Animals; Cell Hypoxia / physiology; Cell Hypoxia / radiation effects; Combined Modality Therapy / methods; Combined Modality Therapy / veterinary; Dog Diseases / metabolism; Dog Diseases / therapy; Dogs; Hyperthermia, Induced / methods; Hyperthermia, Induced / veterinary; Oxygen / analysis; Oxygen / metabolism; Sarcoma / metabolism; Sarcoma / therapy; Sarcoma / veterinary
TL;DR:
There was an increase in oxygenation in tumours with low pre-treatment oxygenation that persisted throughout treatment, an advantageous hyperthermia effect as it may lead to increased radiation cell killing at each fraction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Extracellular pH and P-31 magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy
CLINICAL CANCER RESEARCH, 12(19), 5733–5740.
MeSH headings : Animals; Combined Modality Therapy; Disease Models, Animal; Dog Diseases / pathology; Dog Diseases / therapy; Dogs; Female; Hydrogen-Ion Concentration; Hyperthermia, Induced; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Phosphorus Isotopes; Prospective Studies; Radiotherapy Dosage; Sarcoma / pathology; Sarcoma / therapy; Sarcoma / veterinary; Soft Tissue Neoplasms / pathology; Soft Tissue Neoplasms / therapy; Soft Tissue Neoplasms / veterinary; Treatment Outcome
TL;DR:
PHe was predictive of metastasis and OS in canine spontaneous sarcomas, the first time that pHe has been shown to be predictive of clinical outcome, and the results suggest that additional studies should be considered evaluating the prognostic significance of this variable.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Phase I trial of doxorubicin-containing low temperature sensitive liposomes in spontaneous canine tumors
CLINICAL CANCER RESEARCH, 12(13), 4004–4010.
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / adverse effects; Antineoplastic Agents / pharmacokinetics; Carcinoma / therapy; Carcinoma / veterinary; Combined Modality Therapy; Dog Diseases / therapy; Dogs; Dose-Response Relationship, Drug; Doxorubicin / administration & dosage; Doxorubicin / adverse effects; Doxorubicin / pharmacokinetics; Drug Administration Schedule; Drug Delivery Systems; Female; Hyperthermia, Induced / methods; Liposomes; Male; Maximum Tolerated Dose; Microwaves / therapeutic use; Sarcoma / therapy; Sarcoma / veterinary; Temperature; Treatment Outcome
TL;DR:
LTSL-doxorubicin offers a novel approach to improving drug delivery to solid tumors and was well tolerated and resulted in favorable response profiles in these patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Thermal dose is related to duration of local control in canine sarcomas treated with thermoradiotherapy
Clinical Cancer Research, 11(14), 5206–5214.
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
The physiological and behavioural impacts of and preference for an enriched environment in the eastern box turtle (Terrapene carolina carolina)
APPLIED ANIMAL BEHAVIOUR SCIENCE, 92(4), 353–365.
author keywords: turtle; enrichment; preference tests; housing
TL;DR:
Turtles in enriched enclosures had a significantly lower heterophil to lymphocyte ratio (H/L) at the end of the treatment period and spent significantly less time engaged in escape behaviour.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(OpenAlex)
13. Climate Action
(Web of Science)
14. Life Below Water
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2000 journal article
The pharmacokinetics and pharmacodynamics of GW395058, a peptide agonist of the thrombopoietin receptor, in the dog, a large-animal model of chemotherapy-induced thrombocytopenia
STEM CELLS, 18(5), 360–365.
author keywords: thrombocytopenia; thrombopoietin; mimetic peptide; GW395058; canine; pharmacokinetics; pharmacodynamics
MeSH headings : Animals; Carboplatin / toxicity; Dogs; Female; Injections, Intravenous; Injections, Subcutaneous; Leukocyte Count / drug effects; Male; Metabolic Clearance Rate; Molecular Mimicry; Neoplasm Proteins; Neutrophils / drug effects; Peptides / blood; Peptides / pharmacokinetics; Peptides / pharmacology; Platelet Count / drug effects; Proto-Oncogene Proteins / agonists; Proto-Oncogene Proteins / physiology; Receptors, Cytokine; Receptors, Thrombopoietin; Thrombocytopenia / blood; Thrombocytopenia / chemically induced; Thrombocytopenia / therapy; Thrombopoietin / physiology
TL;DR:
The pharmacokinetics and pharmacodynamics of GW395058 were characterized using a randomized, crossover study in a large‐animal model (dog) of chemotherapy‐induced thrombocytopenia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Using units of CEM 43 degrees C T-90, local hyperthermia thermal dose can be delivered as prescribed
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 16(5), 415–428.
author keywords: dog; hyperthermia; thermal dose
MeSH headings : Animals; Catheterization; Combined Modality Therapy; Dogs; Dose-Response Relationship, Radiation; Hyperthermia, Induced / methods; Radiotherapy / methods; Sarcoma / pathology; Sarcoma / therapy; Sarcoma / veterinary; Temperature; Time Factors
TL;DR:
Relatively simple but accurate methods of delivering prescribed thermal dose as described herein will aid the translation of clinicalhyperthermia from the research setting into more general practice once the characteristics of the relationship between hyperthermia dose and outcome are understood.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Phase I and pharmacokinetic analysis of high-dose tamoxifen and chemotherapy in normal and tumor-bearing dogs
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 44(1), 74–80.
author keywords: P-glycoprotein 170; multidrug resistance; tamoxifen; doxorubicin; canine
MeSH headings : ATP Binding Cassette Transporter, Subfamily B, Member 1 / biosynthesis; ATP Binding Cassette Transporter, Subfamily B, Member 1 / drug effects; Animals; Antineoplastic Agents, Hormonal / administration & dosage; Antineoplastic Agents, Hormonal / adverse effects; Antineoplastic Agents, Hormonal / pharmacokinetics; Digestive System / drug effects; Dogs; Dose-Response Relationship, Drug; Doxorubicin / adverse effects; Doxorubicin / pharmacokinetics; Drug Interactions; Drug Resistance, Multiple; Female; Male; Neoplasms, Experimental / metabolism; Tamoxifen / administration & dosage; Tamoxifen / adverse effects; Tamoxifen / pharmacokinetics; Tissue Distribution
TL;DR:
Concentrations of tamoxifen/NDMT sufficient to inhibit Pgp may be achieved in dogs receiving full-dose chemotherapy with a moderate but acceptable increase in gastrointestinal toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Use of whole body hyperthermia as a method to heat inaccessible tumours uniformly: a phase III trial in canine brain masses
International Journal of Hyperthermia, 15(5), 383–398.
Source: NC State University Libraries
Added: August 6, 2018
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