Beth Catherine Case

Works (30)

Updated: March 4th, 2026 08:00

2026 article

A reliable and holistic approach to evaluating hearing and cognitive auditory processing in adult and aged companion dogs

Yang, C.-C., Ruggeri, M., Simon, K. E., Case, B., Griffith, E. H., Gruen, M. E., & Olby, N. J. (2026, February 10). Scientific Reports, Vol. 2.

By: C. Yang n, M. Ruggeri n, K. Simon n, B. Case n, E. Griffith n , M. Gruen n , N. Olby n 

topics (OpenAlex): Human-Animal Interaction Studies; Veterinary Oncology Research; Veterinary Medicine and Surgery; Hearing, Cochlea, Tinnitus, Genetics; Marine animal studies overview
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4. Quality Education (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: March 3, 2026

2025 article

Quantifying placebo and trial participation effects on cognitive outcome measures in aging dogs

Simon, K. E., Russell, K., Mondino, A., Yang, C.-C., Case, B. C., Anderson, Z., … Olby, N. J. (2025, August 11). GeroScience, Vol. 8.

By: K. Simon n, K. Russell n, A. Mondino n , C. Yang n, B. Case n, Z. Anderson n, C. Whitley n, E. Griffith n , M. Gruen n , N. Olby* 

author keywords: Placebo effect; Trial participation effect; Canine cognitive dysfunction; Canine gerontology; Trial design
MeSH headings : Dogs; Animals; Placebo Effect; Male; Female; Humans; Cognitive Dysfunction; Cognition; Aging / psychology; Longitudinal Studies
topics (OpenAlex): Pain Management and Placebo Effect; Pediatric Pain Management Techniques; Empathy and Medical Education
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 11, 2025

2024 article

A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD+ precursor combination

Simon, K. E., Russell, K., Mondino, A., Yang, C.-C., Case, B. C., Anderson, Z., … Olby, N. J. (2024, May 29). Scientific Reports, Vol. 14.

By: K. Simon n, K. Russell n, A. Mondino n , C. Yang n, B. Case n, Z. Anderson n, C. Whitley n, E. Griffith n , M. Gruen n , N. Olby n 

author keywords: Aging; Senolytic; NAD plus; Canine cognitive dysfunction syndrome; Cognitive impairment; Longevity
MeSH headings : Animals; Dogs; Male; Cognition; Female; Cognitive Dysfunction; NAD / metabolism; Dog Diseases / psychology; Humans
topics (OpenAlex): Human-Animal Interaction Studies; Gut microbiota and health; Dementia and Cognitive Impairment Research
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Sources: Web Of Science, NC State University Libraries
Added: June 24, 2024

2023 article

A novel task of canine olfaction for use in adult and senior pet dogs

Khan, M. Z., Mondino, A., Russell, K., Case, B., Fefer, G., Woods, H., … Gruen, M. (2023, February 8). Scientific Reports, Vol. 13.

By: M. Khan n, A. Mondino n , K. Russell n, B. Case n, G. Fefer n, H. Woods n, N. Olby n , M. Gruen n 

MeSH headings : Dogs; Animals; Smell; Food; Aging; Neuropsychological Tests
topics (OpenAlex): Human-Animal Interaction Studies; Olfactory and Sensory Function Studies; Animal Behavior and Welfare Studies
TL;DR: A novel olfaction test using spontaneous search behavior in dogs to find a hidden food treat in a three-choice task with both light-phase and dark-phase conditions is described, making it feasible to compare between and within groups of pet dogs. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 19, 2023

2023 article

Activity patterns are associated with fractional lifespan, memory, and gait speed in aged dogs

Mondino, A., Khan, M., Case, B., Giovagnoli, S., Thomson, A., Lascelles, B. D. X., … Olby, N. (2023, February 14). Scientific Reports, Vol. 13.

By: A. Mondino  n, M. Khan n, B. Case n, S. Giovagnoli *, A. Thomson n, B. Lascelles n , M. Gruen n , N. Olby n 

MeSH headings : Humans; Dogs; Animals; Alzheimer Disease; Longevity; Walking Speed; Gait; Cognition; Cognitive Dysfunction; Aging / psychology; Pain
topics (OpenAlex): Human-Animal Interaction Studies; Veterinary Orthopedics and Neurology; Veterinary Medicine and Surgery
TL;DR: It is found that activity patterns in dogs are associated with fractional lifespan and working memory, and dogs with higher on/off leash gait speed are more active in the afternoon of weekdays. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 19, 2023

2023 article

Longitudinal Analysis of Canine Oral Microbiome Using Whole Genome Sequencing in Aging Companion Dogs

Templeton, G. B., Fefer, G., Case, B. C., Roach, J., Azcarate-Peril, M. A., Gruen, M. E., … Olby, N. J. (2023, December 14). Animals, Vol. 13.

By: G. Templeton n, G. Fefer n, B. Case n, J. Roach *, M. Azcarate-Peril *, M. Gruen n , B. Callahan n , N. Olby n 

author keywords: oral; microbiome; canine cognitive dysfunction syndrome; Alzheimer's disease
topics (OpenAlex): Gut microbiota and health; Oral microbiology and periodontitis research; Probiotics and Fermented Foods
TL;DR: The importance of defining the oral microbiota in aged dogs with a view to understanding potential therapeutic targets is shown, with an increased fungal and bacterial alpha diversity in aging dogs over time and nearly universal oral dysbiosis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 16, 2024

2023 article

Relationship between engagement with the impossible task, cognitive testing, and cognitive questionnaires in a population of aging dogs

Khan, M. Z., Mondino, A., Russell, K., Case, B., Fefer, G., Woods, H., … Gruen, M. E. (2023, January 4). Frontiers in Veterinary Science, Vol. 9.

By: M. Khan n, A. Mondino n , K. Russell n, B. Case n, G. Fefer n, H. Woods n, N. Olby n , M. Gruen n 

author keywords: canine cognitive dysfunction syndrome; canine cognition; frustration; aging; dogs
topics (OpenAlex): Human-Animal Interaction Studies; Olfactory and Sensory Function Studies; Neuroendocrine regulation and behavior
TL;DR: The high correlation with several cognitive measures and the ease of administration of this test makes it a useful tool in evaluating canine cognitive dysfunction syndrome, however it is unclear if increased frustration or other cognitive processes are contributing to the observed changes. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023

2023 article

Winning the race with aging: age-related changes in gait speed and its association with cognitive performance in dogs

Mondino, A., Khan, M., Case, B., Fefer, G., Panek, W. K., Gruen, M. E., & Olby, N. J. (2023, June 15). Frontiers in Veterinary Science, Vol. 10.

By: A. Mondino n , M. Khan n, B. Case n, G. Fefer n, W. Panek n , M. Gruen n , N. Olby n 

author keywords: canine cognitive dysfunction syndrome; canine gerontology; mobility; walking speed; memory; attention
topics (OpenAlex): Human-Animal Interaction Studies; Veterinary Orthopedics and Neurology; Veterinary Oncology Research
TL;DR: Dogs' food-motivated gait speed off leash is correlated with fractional lifespan and cognitive performance in dogs, particularly in the domains of attention and working memory and proves to be a more effective indicator of age-related deterioration and cognitive decline than gaitspeed on leash. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: July 24, 2023

2022 article

A Pilot, Open-Label Study to Evaluate the Efficacy of Intra-Articular Administration of a Caninized TNF Receptor Fc Fusion Protein as a Treatment for Osteoarthritis-Associated Joint Pain

Nakanishi, A., Lascelles, B. D. X., Allen, J., Case, B., Gearing, D., & Enomoto, M. (2022, June 2). Frontiers in Veterinary Science, Vol. 6.

By: A. Nakanishi n , B. Lascelles n , J. Allen n, B. Case n, D. Gearing* & M. Enomoto n 

author keywords: osteoarthritis; joint pain; TNF-alpha; force plate; limb use asymmetry test
topics (OpenAlex): Veterinary Orthopedics and Neurology; Osteoarthritis Treatment and Mechanisms; Orthopedic Surgery and Rehabilitation
TL;DR: The IA injection of caTNFR-Fc fusion protein provided no benefit in terms of objective limb use and activity data in dogs with OA in this pilot study, and data indicate TNF-α may not be a good therapeutic target in canine OA. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 27, 2022

2022 article

Relationship between hearing, cognitive function, and quality of life in aging companion dogs

Fefer, G., Khan, M. Z., Panek, W. K., Case, B., Gruen, M. E., & Olby, N. J. (2022, August 6). Journal of Veterinary Internal Medicine, Vol. 8.

By: G. Fefer n, M. Khan n, W. Panek n , B. Case n, M. Gruen n  & N. Olby n 

author keywords: canine cognitive dysfunction syndrome; CCDS; cognitive testing; dementia; presbycusis
MeSH headings : Aging; Animals; Cognition; Dementia / epidemiology; Dog Diseases; Dogs; Hearing; Humans; Pets; Presbycusis / epidemiology; Presbycusis / veterinary; Prospective Studies; Quality of Life
topics (OpenAlex): Human-Animal Interaction Studies; Ear Surgery and Otitis Media; Hearing Loss and Rehabilitation
TL;DR: Presbycusis negatively alters owner‐pet interactions and is associated with poor executive performance and owner‐assessed dementia severity, and in multivariate analysis, higher CADES score was associated with worse hearing. (via Semantic Scholar)
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1. No Poverty (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 22, 2022

2022 article

Use of Cognitive Testing, Questionnaires, and Plasma Biomarkers to Quantify Cognitive Impairment in an Aging Pet Dog Population

Fefer, G., Panek, W. K., Khan, M. Z., Singer, M., Westermeyer, H. D., Mowat, F. M., … Gruen, M. E. (2022, April 15). Journal of Alzheimer s Disease.

By: G. Fefer n, W. Panek n , M. Khan n, M. Singer n, H. Westermeyer n , F. Mowat n, D. Murdoch *, B. Case n, N. Olby n , M. Gruen n 

author keywords: Blood biomarkers; canine cognitive dysfunction syndrome; CCDS; cognitive testing; dementia; neurofilament light chain; NfL
MeSH headings : Aging; Animals; Biomarkers; Cognitive Dysfunction / diagnostic imaging; Dogs; Humans; Neuropsychological Tests; Surveys and Questionnaires
topics (OpenAlex): Human-Animal Interaction Studies; Neuroinflammation and Neurodegeneration Mechanisms; Gut microbiota and health
TL;DR: It is suggested that a multi-dimensional approach using a combination of questionnaires, specific cognitive tests, and pNfL concentration can be used to quantify cognitive decline in aging pet dogs. (via Semantic Scholar)
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10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 20, 2022

2021 article

Sustained Gaze Is a Reliable In-home Test of Attention for Aging Pet Dogs

Hoel, J. A., Templeton, G. B., Fefer, G., Case, B. C., Shah, A., Gruen, M. E., & Olby, N. J. (2021, December 23). Frontiers in Veterinary Science, Vol. 12.

By: J. Hoel n, G. Templeton n, G. Fefer n, B. Case n, A. Shah n, M. Gruen n , N. Olby n 

author keywords: Canine Cognitive Dysfunction Syndrome; cognitive testing; dementia; executive function; attention; cognitive impairment
topics (OpenAlex): Human-Animal Interaction Studies; Neuroendocrine regulation and behavior; Primate Behavior and Ecology; Veterinary Medicine and Surgery
TL;DR: It is concluded that owners can perform the sustained gaze test at home and that data generated are reliable and correlate to CADES, a validated measure of dementia. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 24, 2022

2020 article

Evaluation of repeated dosing of a dexmedetomidine oromucosal gel for treatment of noise aversion in dogs over a series of noise events

Gruen, M., Case, B. C., Robertson, J. B., Campbell, S., & Korpivaara, M. E. (2020, September 29). Veterinary Record, Vol. 187, pp. 489–489.

By: M. Gruen n , B. Case n, J. Robertson n , S. Campbell * & M. Korpivaara *

MeSH headings : Animals; Anti-Anxiety Agents / administration & dosage; Anti-Anxiety Agents / therapeutic use; Anxiety / drug therapy; Behavior, Animal / drug effects; Cost of Illness; Dexmedetomidine / administration & dosage; Dexmedetomidine / therapeutic use; Dogs / psychology; Fear / drug effects; Female; Gels; Humans; Male; Noise / adverse effects; Surveys and Questionnaires
topics (OpenAlex): Human-Animal Interaction Studies; Marine animal studies overview; Olfactory and Sensory Function Studies
TL;DR: Repeated use of dexmedetomidine gel for noise events resulted in decreased need for administration and overall burden of care was manageable, yet many owners agreed with statements regarding frustration, stress, guilt, guilt and sadness about their dog’s condition. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 30, 2020

2016 journal article

Evaluation of Clinical Metrology Instrument in Dogs with Osteoarthritis

Journal of Veterinary Internal Medicine, 30(3), 836–846.

By: C. Muller n, B. Gaines n, M. Gruen n , B. Case n, K. Arrufat n, J. Innes *, B. Lascelles n 

author keywords: Analgesia; Client metrology instrument; Degenerative joint disease; Questionnaire
MeSH headings : Animals; Antibodies / immunology; Antibodies / therapeutic use; Dog Diseases / immunology; Dog Diseases / physiopathology; Dog Diseases / therapy; Dogs; Double-Blind Method; Immunotherapy / veterinary; Nerve Growth Factor / immunology; Osteoarthritis / physiopathology; Osteoarthritis / therapy; Osteoarthritis / veterinary; Pain / drug therapy; Pain / veterinary; Pain Measurement / veterinary; Pilot Projects; Proof of Concept Study
topics (OpenAlex): Veterinary Orthopedics and Neurology; Veterinary Equine Medical Research; Human-Animal Interaction Studies
TL;DR: There is little difference between independent and dependent interviewing, however, dependent interviewing resulted in increased treatment effect sizes and investigators could increase clinical trial power through minimal change to study design. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

Widespread somatosensory sensitivity in naturally occurring canine model of osteoarthritis

PAIN, 157(6), 1325–1332.

By: D. Knazovicky n , E. Helgeson  n, B. Case n, M. Gruen n , W. Maixner n & B. Lascelles n 

Contributors: D. Knazovicky n , E. Helgeson  n, B. Case n, M. Gruen n , W. Maixner n & B. Lascelles n 

author keywords: Animal model; Osteoarthritis; Spontaneous osteoarthritis model; Quantitative sensory testing
MeSH headings : Animals; Arthralgia / physiopathology; Arthralgia / veterinary; Central Nervous System Sensitization / physiology; Dogs; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain Measurement; Pain Threshold / physiology; Physical Stimulation; Sensory Thresholds / physiology
topics (OpenAlex): Veterinary Orthopedics and Neurology; Osteoarthritis Treatment and Mechanisms; Veterinary Equine Medical Research
TL;DR: The canine spontaneous OA model is associated with somatosensory sensitivity, likely indicative of central sensitization in human patients' chronic pain, and is validated as an appropriate model of the human OA pain condition. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

A canine-specific anti-nerve growth factor antibody alleviates pain and improves mobility and function in dogs with degenerative joint disease-associated pain

BMC Veterinary Research, 11(1), 101.

By: B. Lascelles n , D. Knazovicky n , B. Case n, M. Freire* , J. Innes, A. Drew*, D. Gearing*

Contributors: B. Lascelles n , D. Knazovicky n , B. Case n, M. Freire* , J. Innes, A. Drew*, D. Gearing*

author keywords: Nerve growth factor; Dog; Antibody; Pain; Model; Osteoarthritis; Accelerometry; Actimetry
MeSH headings : Animals; Antibodies / immunology; Antibodies / therapeutic use; Dog Diseases / therapy; Dogs; Double-Blind Method; Female; Immunotherapy / veterinary; Male; Nerve Growth Factor / immunology; Osteoarthritis / therapy; Osteoarthritis / veterinary; Pain / drug therapy; Pain / veterinary
topics (OpenAlex): Veterinary Orthopedics and Neurology; Tendon Structure and Treatment; Veterinary Equine Medical Research
TL;DR: These pilot data demonstrate a positive analgesic effect of anti-NGF antibody in dogs suffering from chronic pain, similar to that expected with an NSAID. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2015 article

A test for the evaluation of emotional reactivity in Labrador retrievers used for explosives detection

Sherman, B. L., Gruen, M. E., Case, B. C., Foster, M. L., Fish, R. E., Lazarowski, L., … Dorman, D. C. (2015, January 7). Journal of Veterinary Behavior, Vol. 10, pp. 94–102.

By: B. Sherman n, M. Gruen n , B. Case n, M. Foster n, R. Fish n, L. Lazarowski n, V. DePuy, D. Dorman n

author keywords: emotional reactivity test; anxiety scores; selection criteria; behavioral screening; explosives detection dog
topics (OpenAlex): Human-Animal Interaction Studies; Animal Behavior and Welfare Studies; Veterinary Practice and Education Studies
TL;DR: It is concluded that the ERT is a useful pre-training screening test that can be used to identify dogs with a low threshold of emotional reactivity for rejection, anddogs with a high threshold of emotions for entry into the IDD training program. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 article

The use of an open-field model to assess sound-induced fear and anxiety-associated behaviors in Labrador retrievers

Gruen, M. E., Case, B. C., Foster, M. L., Lazarowski, L., Fish, R. E., Landsberg, G., … Sherman, B. L. (2015, May 3). Journal of Veterinary Behavior, Vol. 10, pp. 338–345.

By: M. Gruen n , B. Case n, M. Foster n, L. Lazarowski n, R. Fish n, G. Landsberg, V. DePuy, D. Dorman n, B. Sherman n

author keywords: military working dogs; open-field test; fear; anxiety; thunderstorm; gunfire
topics (OpenAlex): Human-Animal Interaction Studies; Animal Behavior and Welfare Studies; Marine animal studies overview
TL;DR: In general, candidate IED-detection Labrador retrievers responded to sound stimuli and recovered quickly, although dogs stratified in their response to sound stimulus, suggesting that dogs habituated to the open field arena. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 article

Use of oral trazodone for sedation in cats: a pilot study

Orlando, J. M., Case, B. C., Thomson, A. E., Griffith, E., & Sherman, B. L. (2015, June 2). Journal of Feline Medicine and Surgery, Vol. 18, pp. 476–482.

By: J. Orlando n, B. Case n, A. Thomson n, E. Griffith n  & B. Sherman n

MeSH headings : Accelerometry / veterinary; Administration, Oral; Animals; Anti-Anxiety Agents / administration & dosage; Behavior, Animal / drug effects; Cats / physiology; Male; Pilot Projects; Trazodone / administration & dosage; Treatment Outcome
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Human-Animal Interaction Studies; Pediatric Pain Management Techniques
TL;DR: Trazodone was well tolerated in this population of cats and caused appreciable sedation at all doses and further studies are recommended to investigate the use of oral trazodone in cats for the purpose of decreasing anxiety assocaited with transportation and examination. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 article

Acquisition of a visual discrimination and reversal learning task by Labrador retrievers

Lazarowski, L., Foster, M. L., Gruen, M. E., Sherman, B. L., Case, B. C., Fish, R. E., … Dorman, D. C. (2013, November 25). Animal Cognition, Vol. 17, pp. 787–792.

By: L. Lazarowski n, M. Foster n, M. Gruen n , B. Sherman n, B. Case n, R. Fish n, N. Milgram*, D. Dorman n

author keywords: Dog; Canine; Cognition; Visual discrimination
MeSH headings : Animals; Cognition; Discrimination Learning; Discrimination, Psychological; Dogs / psychology; Female; Male; Neuropsychological Tests; Pattern Recognition, Visual; Reversal Learning; Visual Perception
topics (OpenAlex): Human-Animal Interaction Studies; Animal Behavior and Welfare Studies; Wildlife Ecology and Conservation
TL;DR: The present study confirmed that the modified TGTA system is suitable for cognitive evaluations in Labrador retriever MWDs and can be used to further explore effects of sex, phenotype, age, and other factors in relation to canine cognition and learning, and may provide an additional screening tool for MWD selection. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 article

Thermal dose fractionation affects tumour physiological response

Thrall, D. E., Maccarini, P., Stauffer, P., Macfall, J., Hauck, M., Snyder, S., … Dewhirst, M. W. (2012, July 17). International Journal of Hyperthermia.

By: D. Thrall n, P. Maccarini*, P. Stauffer *, J. Macfall *, M. Hauck n, S. Snyder n, B. Case n, K. Linder n ...

author keywords: thermal dosimetry; tumor oxygenation; microenvironment
MeSH headings : Animals; Antigens, Neoplasm / metabolism; Carbonic Anhydrases / metabolism; Caspase 3 / metabolism; Dogs; Hyperthermia, Induced; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Sarcoma / metabolism; Sarcoma / pathology; Sarcoma / therapy; Soft Tissue Neoplasms / metabolism; Soft Tissue Neoplasms / pathology; Soft Tissue Neoplasms / therapy; Tumor Burden; Vascular Endothelial Growth Factor A / metabolism
topics (OpenAlex): Ultrasound and Hyperthermia Applications; Photoacoustic and Ultrasonic Imaging; Ultrasound Imaging and Elastography
TL;DR: There was a greater reduction in tumour volume and water diffusion at the end of therapy in tumours receiving one hyperthermia fraction per week, and response data pointed to a one per week prescription being superior. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 article

Changes in tumour oxygenation during fractionated hyperthermia and radiation therapy in spontaneous canine sarcomas

Thrall, D. E., LaRue, S. M., Pruitt, A. F., Case, B., & Dewhirst, M. W. (2006, January 1). International Journal of Hyperthermia.

By: D. Thrall n, S. LaRue *, A. Pruitt n, B. Case n & M. Dewhirst*

author keywords: hyperthermia; radiation therapy; dog; oxygen measurements
MeSH headings : Animals; Cell Hypoxia / physiology; Cell Hypoxia / radiation effects; Combined Modality Therapy / methods; Combined Modality Therapy / veterinary; Dog Diseases / metabolism; Dog Diseases / therapy; Dogs; Hyperthermia, Induced / methods; Hyperthermia, Induced / veterinary; Oxygen / analysis; Oxygen / metabolism; Sarcoma / metabolism; Sarcoma / therapy; Sarcoma / veterinary
topics (OpenAlex): Ultrasound and Hyperthermia Applications; Sarcoma Diagnosis and Treatment; Virus-based gene therapy research
TL;DR: There was an increase in oxygenation in tumours with low pre-treatment oxygenation that persisted throughout treatment, an advantageous hyperthermia effect as it may lead to increased radiation cell killing at each fraction. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2006 article

Extracellular pH and P-31 Magnetic Resonance Spectroscopic Variables are Related to Outcome in Canine Soft Tissue Sarcomas Treated with Thermoradiotherapy

Lora-Michiels Michaël, Yu, D., Sanders, L., Poulson, J. M., Azuma, C., Case, B., … Dewhirst, M. W. (2006, October 1). Clinical Cancer Research.

By: M. Lora-Michiels*, D. Yu *, L. Sanders*, J. Poulson*, C. Azuma*, B. Case n, Z. Vujaskovic*, D. Thrall n, H. Charles *, M. Dewhirst *

MeSH headings : Animals; Combined Modality Therapy; Disease Models, Animal; Dog Diseases / pathology; Dog Diseases / therapy; Dogs; Female; Hydrogen-Ion Concentration; Hyperthermia, Induced; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Phosphorus Isotopes; Prospective Studies; Radiotherapy Dosage; Sarcoma / pathology; Sarcoma / therapy; Sarcoma / veterinary; Soft Tissue Neoplasms / pathology; Soft Tissue Neoplasms / therapy; Soft Tissue Neoplasms / veterinary; Treatment Outcome
topics (OpenAlex): Sarcoma Diagnosis and Treatment; Veterinary Oncology Research; Virus-based gene therapy research
TL;DR: PHe was predictive of metastasis and OS in canine spontaneous sarcomas, the first time that pHe has been shown to be predictive of clinical outcome, and the results suggest that additional studies should be considered evaluating the prognostic significance of this variable. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2006 article

Phase I Trial of Doxorubicin-Containing Low Temperature Sensitive Liposomes in Spontaneous Canine Tumors

Hauck, M. L., LaRue, S. M., Petros, W. P., Poulson, J. M., Yu, D., Spasojevic, I., … Dewhirst, M. W. (2006, July 1). Clinical Cancer Research.

By: M. Hauck n, S. LaRue *, W. Petros *, J. Poulson*, D. Yu, I. Spasojevic, A. Pruitt n, A. Klein n ...

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / adverse effects; Antineoplastic Agents / pharmacokinetics; Carcinoma / therapy; Carcinoma / veterinary; Combined Modality Therapy; Dog Diseases / therapy; Dogs; Dose-Response Relationship, Drug; Doxorubicin / administration & dosage; Doxorubicin / adverse effects; Doxorubicin / pharmacokinetics; Drug Administration Schedule; Drug Delivery Systems; Female; Hyperthermia, Induced / methods; Liposomes; Male; Maximum Tolerated Dose; Microwaves / therapeutic use; Sarcoma / therapy; Sarcoma / veterinary; Temperature; Treatment Outcome
topics (OpenAlex): RNA Interference and Gene Delivery; Virus-based gene therapy research; Nanoparticle-Based Drug Delivery
TL;DR: LTSL-doxorubicin offers a novel approach to improving drug delivery to solid tumors and was well tolerated and resulted in favorable response profiles in these patients. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Thermal dose is related to duration of local control in canine sarcomas treated with thermoradiotherapy

Clinical Cancer Research, 11(14), 5206–5214.

By: D. Thrall, S. Larue, D. Yu, T. Samulski, L. Sanders, B. Case, G. Rosner, C. Azuma ...

Source: NC State University Libraries
Added: August 6, 2018

2004 article

The physiological and behavioural impacts of and preference for an enriched environment in the eastern box turtle (Terrapene carolina carolina)

Case, B. C., Lewbart, G. A., & Doerr, P. D. (2004, December 29). Applied Animal Behaviour Science, Vol. 92, pp. 353–365.

By: B. Case n, G. Lewbart n  & P. Doerr n

author keywords: turtle; enrichment; preference tests; housing
topics (OpenAlex): Turtle Biology and Conservation; Amphibian and Reptile Biology; Bird parasitology and diseases
TL;DR: Turtles in enriched enclosures had a significantly lower heterophil to lymphocyte ratio (H/L) at the end of the treatment period and spent significantly less time engaged in escape behaviour. (via Semantic Scholar)
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11. Sustainable Cities and Communities (OpenAlex)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 article

The Pharmacokinetics and Pharmacodynamics of GW395058, a Peptide Agonist of the Thrombopoietin Receptor, in the Dog, a Large‐Animal Model of Chemotherapy‐Induced Thrombocytopenia

Case, B. C., Hauck, M. L., Yeager, R. L., Simkins, A. H., Serres, M., Schmith, V. D., … Page, R. L. (2000, September 1). Stem Cells.

By: B. Case*, M. Hauck*, R. Yeager*, A. Simkins*, M. Serres*, V. Schmith *, J. Dillberger*, R. Page n

author keywords: thrombocytopenia; thrombopoietin; mimetic peptide; GW395058; canine; pharmacokinetics; pharmacodynamics
MeSH headings : Animals; Carboplatin / toxicity; Dogs; Female; Injections, Intravenous; Injections, Subcutaneous; Leukocyte Count / drug effects; Male; Metabolic Clearance Rate; Molecular Mimicry; Neoplasm Proteins; Neutrophils / drug effects; Peptides / blood; Peptides / pharmacokinetics; Peptides / pharmacology; Platelet Count / drug effects; Proto-Oncogene Proteins / agonists; Proto-Oncogene Proteins / physiology; Receptors, Cytokine; Receptors, Thrombopoietin; Thrombocytopenia / blood; Thrombocytopenia / chemically induced; Thrombocytopenia / therapy; Thrombopoietin / physiology
topics (OpenAlex): Platelet Disorders and Treatments; Blood groups and transfusion; Blood properties and coagulation
TL;DR: The pharmacokinetics and pharmacodynamics of GW395058 were characterized using a randomized, crossover study in a large‐animal model (dog) of chemotherapy‐induced thrombocytopenia. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2000 article

Using units of CEM 43°C T90, local hyperthermia thermal dose can be delivered as prescribed

Thrall, D. E., Rosner, G. L., Azuma, C., Larue, S. M., Case, B. C., Samulski, T., & Dewhirst, M. W. (2000, January 1). International Journal of Hyperthermia.

By: D. Thrall n, G. Rosner *, C. Azuma n, S. Larue *, B. Case n, T. Samulski*, M. Dewhirst*

author keywords: dog; hyperthermia; thermal dose
MeSH headings : Animals; Catheterization; Combined Modality Therapy; Dogs; Dose-Response Relationship, Radiation; Hyperthermia, Induced / methods; Radiotherapy / methods; Sarcoma / pathology; Sarcoma / therapy; Sarcoma / veterinary; Temperature; Time Factors
topics (OpenAlex): Ultrasound and Hyperthermia Applications; Infrared Thermography in Medicine; Photoacoustic and Ultrasonic Imaging
TL;DR: Relatively simple but accurate methods of delivering prescribed thermal dose as described herein will aid the translation of clinicalhyperthermia from the research setting into more general practice once the characteristics of the relationship between hyperthermia dose and outcome are understood. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 article

Phase I and pharmacokinetic analysis of high-dose tamoxifen and chemotherapy in normal and tumor-bearing dogs

Waddle, J. R., Fine, R. L., Case, B. C., Trogdon, M. L., Tyczkowska, K., Frazier, D., & Page, R. L. (1999, May 17). Cancer Chemotherapy and Pharmacology.

By: J. Waddle, R. Fine*, B. Case n, M. Trogdon n, K. Tyczkowska n, D. Frazier*, R. Page n

author keywords: P-glycoprotein 170; multidrug resistance; tamoxifen; doxorubicin; canine
MeSH headings : ATP Binding Cassette Transporter, Subfamily B, Member 1 / biosynthesis; ATP Binding Cassette Transporter, Subfamily B, Member 1 / drug effects; Animals; Antineoplastic Agents, Hormonal / administration & dosage; Antineoplastic Agents, Hormonal / adverse effects; Antineoplastic Agents, Hormonal / pharmacokinetics; Digestive System / drug effects; Dogs; Dose-Response Relationship, Drug; Doxorubicin / adverse effects; Doxorubicin / pharmacokinetics; Drug Interactions; Drug Resistance, Multiple; Female; Male; Neoplasms, Experimental / metabolism; Tamoxifen / administration & dosage; Tamoxifen / adverse effects; Tamoxifen / pharmacokinetics; Tissue Distribution
topics (OpenAlex): Drug Transport and Resistance Mechanisms; Neuroendocrine Tumor Research Advances; Cholangiocarcinoma and Gallbladder Cancer Studies
TL;DR: Concentrations of tamoxifen/NDMT sufficient to inhibit Pgp may be achieved in dogs receiving full-dose chemotherapy with a moderate but acceptable increase in gastrointestinal toxicity. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1999 journal article

Use of whole body hyperthermia as a method to heat inaccessible tumours uniformly: a phase III trial in canine brain masses

International Journal of Hyperthermia, 15(5), 383–398.

By: D. Thrall, S. Larue, B. Powers, R. Page, J. Johnson, S. George, J. Kornegay, M. McEntee ...

Source: NC State University Libraries
Added: August 6, 2018

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