Bruce Collins

Works (4)

Updated: July 17th, 2023 21:18

2022 article

Allogeneic and xenogeneic lymphoid reconstitution in a RAG2−/−IL2RGy/− severe combined immunodeficient pig: A preclinical model for intrauterine hematopoietic transplantation

Sper, R. B., Proctor, J., Lascina, O., Guo, L., Polkoff, K., Kaeser, T., … Piedrahita, J. A. (2022, October 14). Frontiers in Veterinary Science, Vol. 9.

By: R. Sper  n, J. Proctor n, O. Lascina n, L. Guo  n, K. Polkoff n, T. Kaeser n , S. Simpson n, L. Borst n  ...

author keywords: severe combined immunodeficiency; pig; xenotransplantation; allotransplantation; hematopoietic; RAG2; IL2RG; transgenic
topics (OpenAlex): Xenotransplantation and immune response; Hematopoietic Stem Cell Transplantation; Diabetes and associated disorders
TL;DR: The data shows that the pig thymus provides a microenvironment conducive to engraftment, survival and development of human T-cells and provides evidence that the developing T-cell compartment can be populated to a significant extent by human cells in large animals. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 14, 2022

2022 article

LGR5 is a conserved marker of hair follicle stem cells in multiple species and is present early and throughout follicle morphogenesis

Polkoff, K. M., Gupta, N. K., Green, A. J., Murphy, Y., Chung, J., Gleason, K. L., … Piedrahita, J. A. (2022, June 1). Scientific Reports, Vol. 12.

By: K. Polkoff n, N. Gupta  n, A. Green n, Y. Murphy n, J. Chung n, K. Gleason n, S. Simpson*, D. Walker n, B. Collins n, J. Piedrahita n 

MeSH headings : Animals; Animals, Genetically Modified; Biomarkers / metabolism; Hair Follicle / metabolism; Humans; Morphogenesis; Receptors, G-Protein-Coupled / genetics; Receptors, G-Protein-Coupled / metabolism; Skin; Stem Cells / metabolism; Swine
topics (OpenAlex): Hair Growth and Disorders; Cancer and Skin Lesions; Skin and Cellular Biology Research
TL;DR: It is demonstrated that LGR5 is a marker of hair follicle stem cells across species in homeostasis and development and the strong similarities and important differences in expression patterns, gene expression profiles, and developmental processes between species are reported. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: June 20, 2022

2021 journal article

Sex‐specific biomechanics and morphology of the anterior cruciate ligament during skeletal growth in a porcine model

Journal of Orthopaedic Research, 40(8), 1853–1864.

By: D. Howe n, S. Cone  n, J. Piedrahita n , B. Collins n, L. Fordham *, E. Griffith n , J. Spang *, M. Fisher n 

author keywords: anterior cruciate ligament; knee; porcine model; skeletal growth
MeSH headings : Adolescent; Aged; Animals; Anterior Cruciate Ligament; Anterior Cruciate Ligament Injuries; Biomechanical Phenomena; Child; Female; Humans; Joint Instability; Knee Joint; Male; Swine; Tibia
topics (OpenAlex): Knee injuries and reconstruction techniques; Sports injuries and prevention; Total Knee Arthroplasty Outcomes
TL;DR: A porcine model is used to investigate the sex-specific morphology and biomechanics of the ACL and its bundles throughout skeletal growth and has implications for age and sex‐specific surgical intervention strategies and suggests the need for human studies. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: November 15, 2021

2018 journal article

High mobility group A2 (HMGA2) deficiency in pigs leads to dwarfism, abnormal fetal resource allocation, and cryptorchidism

Proceedings of the National Academy of Sciences, 115(21), 5420–5425.

By: J. Chung n, X. Zhang n, B. Collins n, R. Sper  n, K. Gleason n, S. Simpson n, S. Koh  n, J. Sommer n ...

author keywords: HMGA2; dwarfism; swine; gene editing; organ size
MeSH headings : Animals; Cryptorchidism / etiology; Cryptorchidism / pathology; Dwarfism / etiology; Dwarfism / pathology; Female; Fetal Diseases / etiology; Fetal Diseases / pathology; Genotype; HMGA2 Protein / deficiency; HMGA2 Protein / genetics; Litter Size; Male; Nuclear Transfer Techniques / veterinary; Pregnancy; Reproduction; Swine; Swine Diseases / etiology; Swine Diseases / pathology
topics (OpenAlex): Animal Genetics and Reproduction; Cancer-related molecular mechanisms research; Genetic and phenotypic traits in livestock
TL;DR: The results show that the effect of HMGA2 with respect to growth regulation is highly conserved among mammals and opens up the possibility of regulating body and organ size in a variety of mammalian species including food and companion animals. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

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