Brian E. Howard

Works (4)

Updated: July 5th, 2023 15:56

2013 article

High-Throughput RNA Sequencing of Pseudomonas-Infected Arabidopsis Reveals Hidden Transcriptome Complexity and Novel Splice Variants

Howard, B. E., Hu, Q., Babaoglu, A. C., Chandra, M., Borghi, M., Tan, X., … Heber, S. (2013, October 1). PLoS ONE, Vol. 8.

By: B. Howard n, Q. Hu  n, A. Babaoglu n, M. Chandra n, M. Borghi n, X. Tan  n, L. He n, H. Winter-Sederoff n  ...

Contributors: B. Howard n, Q. Hu  n, A. Babaoglu n, M. Chandra n, M. Borghi n, X. Tan  n, L. He n, H. Winter-Sederoff n  ...

MeSH headings : Alternative Splicing / genetics; Arabidopsis / microbiology; Exons / genetics; Gene Expression Profiling; Genomics; High-Throughput Nucleotide Sequencing; Introns / genetics; Pseudomonas syringae / genetics; Pseudomonas syringae / physiology; RNA Splice Sites / genetics; Sequence Analysis, RNA; Transcription, Genetic / genetics
topics (OpenAlex): Plant-Microbe Interactions and Immunity; Plant Pathogenic Bacteria Studies; Legume Nitrogen Fixing Symbiosis
TL;DR: A genome-wide analysis of transcription in Arabidopsis thaliana after treatment with Pseudomonas syringae pathovar tomato finds several genes previously known to be alternatively spliced or expressed during the defense response may serve as a pool of candidate genes for regulated alternative splicing with possible biological relevance for thedefense response against invasive pathogens. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2010 article

Towards reliable isoform quantification using RNA-SEQ data

Howard, B. E., & Heber, S. (2010, April 1). BMC Bioinformatics, Vol. 11.

By: B. Howard n & S. Heber n 

MeSH headings : Algorithms; Alternative Splicing / genetics; Arabidopsis / genetics; Base Sequence; Chi-Square Distribution; Computational Biology / methods; Computer Simulation; Databases, Nucleic Acid; Gene Expression Regulation, Plant; Genes, Plant; Linear Models; Models, Genetic; Molecular Sequence Data; Protein Isoforms / analysis; Protein Isoforms / genetics; Sequence Analysis, RNA / methods; Stress, Physiological
topics (OpenAlex): RNA Research and Splicing; RNA modifications and cancer; Cancer-related molecular mechanisms research
TL;DR: This research investigates the use of RNA sequencing datasets to address the isoform quantification problem and identifies several alternatively-spliced genes with switch-like, on/off expression properties, as well as a number of other genes that varied more subtly in isoform expression. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 article

Unsupervised assessment of microarray data quality using a Gaussian mixture model

Howard, B. E., Sick, B., & Heber, S. (2009, June 22). BMC Bioinformatics, Vol. 10.

By: B. Howard n, B. Sick * & S. Heber n 

MeSH headings : Algorithms; Computational Biology / methods; Gene Expression Profiling / methods; Normal Distribution; Oligonucleotide Array Sequence Analysis / methods
topics (OpenAlex): Gene expression and cancer classification; Genetic Mapping and Diversity in Plants and Animals; Bioinformatics and Genomic Networks
TL;DR: This research illustrates the efficacy of an unsupervised classification approach for the purpose of automated microarray data quality assessment, which requires only unannotated training data and is easy to customize and to keep up-to-date as technology evolves. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 article

Accessible proteomics space and its implications for peak capacity for zero‐, one‐ and two‐dimensional separations coupled with FT‐ICR and TOF mass spectrometry

Frahm, J. L., Howard, B. E., Heber, S., & Muddiman, D. C. (2006, March 1). Journal of Mass Spectrometry, Vol. 41, pp. 281–288.

By: J. Frahm n, B. Howard n, S. Heber n  & D. Muddiman n 

MeSH headings : Biotechnology / instrumentation; Biotechnology / methods; Electrophoresis, Gel, Two-Dimensional; Fourier Analysis; Mass Spectrometry; Peptides / analysis; Proteomics / instrumentation; Proteomics / methods
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Advanced Proteomics Techniques and Applications
TL;DR: The results indicate that reverse-phase-nanoHPLC (RP-nHPLC) separation coupled with FT-ICR MS offers an order of magnitude improvement in peak capacity over RP- nHPLC separation coupling with TOF MS, and the addition of an orthogonal separation method, strong cation exchange (SCX), for 2D LC-MS demonstrates an additional 10-fold improvement inpeak capacity over 1D LC -MS methods. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2026) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.