Brandon Pike

Works (5)

Updated: September 30th, 2025 05:03

2025 article

Effects of Maternal Clofibrate Supplementation During Gestation and Lactation on Intestinal Fatty Acid Oxidation of Suckling Piglets

Pike, B., Zhao, J., Hicks, J. A., Wang, F., Meisner, P., Yang, L., … Lin. (2025, September 6). International Journal of Molecular Sciences, Vol. 26.

By: B. Pike n, J. Zhao n, J. Hicks n, F. Wang n, P. Meisner n, L. Yang  n, H. Liu n, J. Odle n , Lin

author keywords: clofibrate; fatty acid (FA); intestinal mucosa; maternal; suckling piglets
topics (OpenAlex): Peroxisome Proliferator-Activated Receptors; Metabolism and Genetic Disorders; Adipose Tissue and Metabolism
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 15, 2025

2024 article

Effects of maternal feeding of clofibrate on hepatic fatty acid metabolism in suckling piglet

Zhao, J., Pike, B., Wang, F., Yang, L., Meisner, P., Huang, Y., … Lin. (2024, December 5). Journal of Animal Science and Biotechnology/Journal of Animal Science and Biotechnology, Vol. 15.

By: J. Zhao n, B. Pike n, F. Wang n, L. Yang  n, P. Meisner n, Y. Huang  n, J. Odle n , Lin

author keywords: Clofibrate; Hepatic fatty acid oxidation and metabolism; Newborn pigs; Postnatal age, PPAR alpha
topics (OpenAlex): Animal Nutrition and Physiology; Peroxisome Proliferator-Activated Receptors; Animal Behavior and Welfare Studies
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Sources: Web Of Science, NC State University Libraries
Added: December 16, 2024

2023 article

Intestinal Carnitine Status and Fatty Acid Oxidation in Response to Clofibrate and Medium-Chain Triglyceride Supplementation in Newborn Pigs

Pike, B., Zhao, J., Hicks, J. A., Wang, F., Hagen, R., Liu, H.-C., … Lin. (2023, March 23). International Journal of Molecular Sciences, Vol. 24.

By: B. Pike n, J. Zhao n, J. Hicks n, F. Wang n, R. Hagen n, H. Liu n, J. Odle n , Lin

author keywords: carnitine; fatty acid oxidation; intestine; medium-chain fatty acid; newborn pigs
MeSH headings : Animals; Swine; Clofibrate / pharmacology; Animals, Newborn; Carnitine / pharmacology; Carnitine / metabolism; Liver / metabolism; Palmitic Acid / pharmacology; Triglycerides / metabolism; Intestines; Dietary Supplements; Fatty Acids / metabolism; Oxidation-Reduction
topics (OpenAlex): Metabolism and Genetic Disorders; Peroxisome Proliferator-Activated Receptors; Clinical Nutrition and Gastroenterology
TL;DR: It is suggested that dietary clofibrate improved carnitine status and increased fatty acid oxidation in neonates, and Propionyl-CoA, generated from TC5 and TMPA, could stimulate the increased fatty acids oxidation rate induced by cl ofibrate as anaplerotic carbon sources. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 25, 2023

2022 article

Alterations in hepatic mitotic and cell cycle transcriptional networks during the metabolic switch in broiler chicks

Hicks, J. A., Pike, B. E., & Liu, H.-C. (2022, October 24). Frontiers in Physiology.

By: J. Hicks n, B. Pike n & H. Liu n

author keywords: broiler; metabolic switch; liver; RNA-seq; mitosis
topics (OpenAlex): Peroxisome Proliferator-Activated Receptors; Drug Transport and Resistance Mechanisms; Mitochondrial Function and Pathology
TL;DR: Estimation patterns suggest that hepatocytes of delayed-fed birds have abnormal mitosis and increased polyploidization, which suggests that post-hatch feed consumption maintains the rate and integrity of liver growth immediately, which in turn, likely helps facilitate the appropriate programming of hepatic metabolic networks. (via Semantic Scholar)
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Source: Web Of Science
Added: November 21, 2022

2022 article

Effects of medium chain triglycerides on hepatic fatty acid oxidation in clofibrate-fed newborn piglets

Zhao, J., Pike, B., Huang, J., Feng, Z., Odle, J., & Lin. (2022, December 8). Animal Nutrition, Vol. 12, pp. 334–344.

By: J. Zhao n, B. Pike n, J. Huang  n, Z. Feng  n, J. Odle n  & Lin

author keywords: PPAR a; Clofibrate; Newborn piglets; Medium chain triglyceride (MCT); Hepatic fatty acid oxidation
topics (OpenAlex): Metabolism and Genetic Disorders; Peroxisome Proliferator-Activated Receptors; Diet and metabolism studies
TL;DR: It is suggested that dietary supplementation of anaplerotic and ketogenic FA could impact FA oxidation and modify the metabolism of acetyl-CoA via alteration of TCA cycle activity, but the modification has no significant impact on the hepatic FA oxidative capacity induced by PPARα. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 20, 2023

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