Brandon Pike

Works (4)

Updated: December 18th, 2024 05:02

2024 journal article

Effects of maternal feeding of clofibrate on hepatic fatty acid metabolism in suckling piglet

JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY, 15(1).

By: J. Zhao n, B. Pike n, F. Wang n, L. Yang  n, P. Meisner n, Y. Huang  n, J. Odle n , . Lin  n

author keywords: Clofibrate; Hepatic fatty acid oxidation and metabolism; Newborn pigs; Postnatal age, PPAR alpha
Sources: Web Of Science, NC State University Libraries
Added: December 16, 2024

2023 journal article

Intestinal Carnitine Status and Fatty Acid Oxidation in Response to Clofibrate and Medium-Chain Triglyceride Supplementation in Newborn Pigs

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(7).

By: B. Pike n, J. Zhao n, J. Hicks n, F. Wang n, R. Hagen n, H. Liu n, J. Odle n , . Lin  n

author keywords: carnitine; fatty acid oxidation; intestine; medium-chain fatty acid; newborn pigs
MeSH headings : Animals; Swine; Clofibrate / pharmacology; Animals, Newborn; Carnitine / pharmacology; Carnitine / metabolism; Liver / metabolism; Palmitic Acid / pharmacology; Triglycerides / metabolism; Intestines; Dietary Supplements; Fatty Acids / metabolism; Oxidation-Reduction
TL;DR: It is suggested that dietary clofibrate improved carnitine status and increased fatty acid oxidation in neonates, and Propionyl-CoA, generated from TC5 and TMPA, could stimulate the increased fatty acids oxidation rate induced by cl ofibrate as anaplerotic carbon sources. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 25, 2023

2022 journal article

Alterations in hepatic mitotic and cell cycle transcriptional networks during the metabolic switch in broiler chicks

FRONTIERS IN PHYSIOLOGY, 13.

By: J. Hicks n, B. Pike n & H. Liu n

author keywords: broiler; metabolic switch; liver; RNA-seq; mitosis
TL;DR: Estimation patterns suggest that hepatocytes of delayed-fed birds have abnormal mitosis and increased polyploidization, which suggests that post-hatch feed consumption maintains the rate and integrity of liver growth immediately, which in turn, likely helps facilitate the appropriate programming of hepatic metabolic networks. (via Semantic Scholar)
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Source: Web Of Science
Added: November 21, 2022

2022 journal article

Effects of medium chain triglycerides on hepatic fatty acid oxidation in clofibrate-fed newborn piglets

ANIMAL NUTRITION, 12, 334–344.

By: J. Zhao n, B. Pike n, J. Huang  n, Z. Feng  n, J. Odle n  & . Lin  n

author keywords: PPAR a; Clofibrate; Newborn piglets; Medium chain triglyceride (MCT); Hepatic fatty acid oxidation
TL;DR: It is suggested that dietary supplementation of anaplerotic and ketogenic FA could impact FA oxidation and modify the metabolism of acetyl-CoA via alteration of TCA cycle activity, but the modification has no significant impact on the hepatic FA oxidative capacity induced by PPARα. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 20, 2023

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