Brian C Gilger
Ocular immunology, pharmacology, drug delivery, gene therapy
Dr. Gilger is a native of Akron, Ohio and received his veterinary degree from the Ohio State University in Columbus, Ohio. After a one-year internship at the Animal Medical Center in New York City, Dr. Gilger worked in a general small animal practice in Atlanta, Georgia. Following a 3 year ophthalmology residency and masters degree at Auburn University in Alabama, Dr. Gilger returned to the Ohio State University as an Assistant Professor of Ophthalmology In 1992. In October 1995, Dr. Gilger joined the faculty at NC State University. His clinical interests include intraocular surgery such as cataract surgery, dry eye treatment and equine ocular disorders. His main research interest is ocular pharmacology, drug delivery, and ocular immunology.
Works (274)
Updated: September 3rd, 2024 08:23
2024 journal article
Causes, treatment, and outcome of hyphema, fibrin, and vitreal hemorrhage in horses: 219 cases (2012–2023)
Journal of the American Veterinary Medical Association.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 1, 2024
2024 journal article
Cold atmospheric plasma inactivates<i> Aspergillus</i><i> flavus</i> and Fusarium keratoplasticum biofilms and conidia in vitro
JOURNAL OF MEDICAL MICROBIOLOGY, 73(7).
author keywords: antifungal; Aspergillus; cold atmospheric plasma; Fusarium; fungal disease.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 15, 2024
2024 journal article
Current therapy and advancements in the treatment of equine fungal keratitis
Journal of the American Veterinary Medical Association.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: July 15, 2024
2024 article
Relationship between stable management practices and ocular disease in horses
Ludwig, C., Barr, E., & Gilger, B. C. (2024, March 4). EQUINE VETERINARY EDUCATION, Vol. 3.
author keywords: horse; corneal ulcer; face mask; hay; owner survey
TL;DR:
Horses kept primarily at pasture have fewer ocular diseases, likely because they sustain less ocular trauma compared to horses kept in stables, and how hay is fed does not correlate with the incidence of corneal or other ocular disease.
(via Semantic Scholar)
open access via onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 8, 2024
2024 journal article
Ultrasound biomicroscopic imaging parameters associated with outcome in equine infectious ulcerative keratitis and stromal abscesses
Journal of the American Veterinary Medical Association.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 1, 2024
2023 journal article
AAV-mediated expression of HLA-G for the prevention of experimental ocular graft vs. host disease
Molecular Therapy - Methods & Clinical Development, 29, 227–235.
TL;DR:
Evidence is provided that subconjunctival AAV targets ocular surface and corneal disease and support that HLA-G-based gene therapy may be an effective treatment for OGvHD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: March 24, 2023
2023 journal article
Additional evidence supports <scp><i>GRM6</i></scp> p.<scp>Thr178Met</scp> as a cause of congenital stationary night blindness in three horse breeds
Veterinary Ophthalmology, 10.
author keywords: allele frequency; CSNB; CSNB2; equine genetics; glutamate metabotropic receptor 6; night blind
TL;DR:
This study represents the largest across-breed identification of CSNB in the horse and suggests that this disorder is likely underdiagnosed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: October 30, 2023
2023 journal article
Application of Noggin-Coated Electrospun Scaffold in Corneal Wound Healing
Translational Vision Science & Technology, 12(8), 15.
TL;DR:
This Noggin-coated electrospun scaffold represents a step toward, expanding treatment options for patients with indolent corneal ulcers, and provides a better perspective for understanding electroSpun scaffolds as a tunable platform to infuse topical therapeutics and use as aCorneal bandage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, ORCID
Added: October 4, 2023
2023 journal article
Effect of gentamicin on <scp>CD3</scp>+ T‐lymphocyte proliferation for treatment of equine recurrent uveitis: An in vitro study
Veterinary Ophthalmology, 26(4), 347–354.
author keywords: autoimmune disease; equine recurrent uveitis; gentamicin; horse; immunology; intravitreal injection
TL;DR:
Gentamicin had no effect on equine peripheral blood CD3+ T-lymphocyte cell viability and proliferation in concentrations ranging from "safe" to "retinotoxic" in relation to intravitreal injection volumes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: April 29, 2023
2023 journal article
Ex vivo analysis of ultraviolet radiation transmission through ocular media and retina in select species
Experimental Eye Research, 233, 109550.
author keywords: Ultraviolet radiation; Ocular media; Canine; Feline; Human; Vision
TL;DR:
The globes of cats and dogs allowed the most amount of UV radiation transmission, while those of pigs and humans allowed the least amount ofUV radiation transmission.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: June 25, 2023
2023 article
Phase-Dependent Differential In Vitro and Ex Vivo Susceptibility of Aspergillus flavus and Fusarium keratoplasticum to Azole Antifungals
Roberts, D., Salmon, J., Cubeta, M. A., & Gilger, B. C. (2023, September 6).
Source: ORCID
Added: September 11, 2023
2023 journal article
Phase-Dependent Differential In Vitro and Ex Vivo Susceptibility of Aspergillus flavus and Fusarium keratoplasticum to Azole Antifungals
Journal of Fungi, 9(10), 966.
author keywords: Aspergillus; Fusarium; fungal keratitis; antifungal susceptibility; MIC; azole
TL;DR:
It is concluded that traditional antifungal susceptibility testing with conidial suspensions does not correlate with fungal susceptibility in cultures of a more advanced developmental phase, and a revised method of antif fungus susceptibility testing that evaluates hyphal susceptibility may better predict fungal response in the clinical setting where treatment is often delayed until days after the initial insult.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: September 27, 2023
2023 journal article
Prevalence, differences, and potential correlation to age, sex, breed, coat color, iris color, and geographic location in naturally occurring refractive errors in the normal equine eye from Germany and North Carolina
Veterinary Ophthalmology, 26(4), 297–305.
author keywords: ametropia; astigmatism; emmetropia; equine ophthalmology; refraction; streak retinoscopy
TL;DR:
Most eyes evaluated are emmetropic, or shifted myopically, with excellent agreement between eyes of the same horse, and sex, iris color, and geographic location appear to impact refraction in horses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: January 25, 2023
2023 article
Relationship between stable management practices and ocular disease in horses
Ludwig, C., Barr, E., & Gilger, B. (2023, October 18).
Source: ORCID
Added: November 3, 2023
2023 journal article
Solving an eye condition by looking to the rear
Equine Veterinary Education, 35(7), 356–357.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: March 14, 2023
2023 journal article
Use of Biologics and Stem Cells in Equine Ophthalmology
VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE, 39(3), 541–552.
author keywords: Equine; Eye; Stem cells; Gene therapy; Biologics
TL;DR:
The use of stem cells or gene therapy has promise for the treatment of Intraocular diseases such as equine recurrent uveitis by providing efficacious, practical, and long-term therapy for these blinding diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 4, 2023
2022 journal article
Developing advanced therapeutics through the study of naturally occurring immune-mediated ocular disease in domestic animals
AMERICAN JOURNAL OF VETERINARY RESEARCH, 83(11).
MeSH headings : Horses; Animals; Humans; Rats; Cats; Dogs; Animals, Domestic; Eye; Mesenchymal Stem Cells; Keratitis / metabolism; Keratitis / veterinary; Uveitis / therapy; Uveitis / veterinary; Cat Diseases; Dog Diseases / metabolism; Horse Diseases / therapy; Horse Diseases / metabolism; Rodent Diseases / metabolism
TL;DR:
Results support that autologous subconjunctival BM-MSC therapy may be a viable treatment alternative for IMMK and that the use of subconJunctival MSCs may be an effective method to treat ocular surface immune-mediated diseases in humans and other species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 5, 2022
2022 chapter
Diseases of the Uvea, Uveitis, and Recurrent Uveitis
In B. C. Gilger (Ed.), Equine Ophthalmology (4th ed., pp. 441–498).
Sources: NC State University Libraries, NC State University Libraries
Added: February 2, 2024
2022 book
Source: Crossref
Added: November 8, 2023
2022 journal article
How study of naturally occurring ocular disease in animals improves ocular health globally
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 260(15), 1887–1893.
MeSH headings : Humans; Horses; Cats; Animals; Dogs; Eye; Uveitis / epidemiology; Uveitis / therapy; Uveitis / veterinary; Glaucoma / veterinary; Retinal Diseases / veterinary; Corneal Ulcer / veterinary; Cat Diseases; Dog Diseases / epidemiology; Dog Diseases / therapy; Horse Diseases / pathology
TL;DR:
The role of naturally occurring ocular disease in animals is reviewed with emphasis on how the understanding of these ocular diseases contributes to one health initiatives, particularly the pathogenesis and treatment of ocular Diseases common to animals and humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023
2022 article
Induced Pluripotent Stem Cell-Derived Corneal Cells: Current Status and Application
Mahmood, N., Suh, T. C., Ali, K. M., Sefat, E., Jahan, U. M., Huang, Y., … Gluck, J. M. (2022, August 1). STEM CELL REVIEWS AND REPORTS, Vol. 8.
author keywords: Cornea; Corneal tissue engineering; Induced pluripotent stem cells; Differentiation; Limbal stem cell deficiency
MeSH headings : Humans; Induced Pluripotent Stem Cells; Cell Differentiation / genetics; Cornea; Cell Line; Corneal Diseases / therapy
TL;DR:
The early development of the cornea is discussed because protocols differentiating iPSCs toward corneal lineages rely heavily upon recapitulating this development, and differentiated iPSC phenotypes have been analyzed with an emphasis on feeder- free, xeno-free, and well-defined protocols, which have clinical relevance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 1, 2022
2022 journal article
Inhibition of experimental autoimmune uveitis by intravitreal AAV-Equine-IL10 gene therapy
PLOS ONE, 17(8).
Ed(s): A. Taylor
MeSH headings : Animals; Autoimmune Diseases; Dependovirus / genetics; Genetic Therapy; Horses / genetics; Humans; Interleukin-10 / genetics; Interleukin-10 / therapeutic use; Rats; Uveitis
TL;DR:
Safety and efficacy of AAV8-Equine-IL10 to prevent EAU are demonstrated and support continued exploration of A AV gene therapy for the treatment of equine and perhaps human recurrent uveitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 19, 2022
2022 journal article
Peptide Inhibitors of MARCKS Suppress Endotoxin Induced Uveitis in Rats
Journal of Ocular Pharmacology and Therapeutics, 38(3), 223–231.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: February 2, 2024
2022 journal article
Polidocanol monotherapy for a superficial orbital venous malformation in a horse
Veterinary Ophthalmology, 25(5), 412–418.
author keywords: horse; monotherapy; orbit; polidocanol; sclerotherapy; venous malformation
MeSH headings : Animals; Horse Diseases / chemically induced; Horse Diseases / diagnostic imaging; Horse Diseases / drug therapy; Horses; Male; Orbital Diseases / veterinary; Polidocanol / therapeutic use; Polyethylene Glycols; Sclerosing Solutions / adverse effects; Sclerosing Solutions / therapeutic use; Sclerotherapy / veterinary; Treatment Outcome; Veins / abnormalities
TL;DR:
Polidocanol as the sole treatment for a superficial orbital venous malformation in a horse was well tolerated and led to clinical resolution, and sclerosant monotherapy may be a safe treatment option for superficial orbital Venous malformations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: June 2, 2022
2022 review
Therapeutic Applications of Adeno-Associated Virus (AAV) Gene Transfer of HLA-G in the Eye
[Review of ]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(7).
author keywords: AAV; HLA-G; dry eye; ocular graft vs; host disease; corneal transplant rejection; uveitis; gene therapy
MeSH headings : Animals; Choroidal Neovascularization / genetics; Dependovirus / genetics; Genetic Therapy; Genetic Vectors / genetics; HLA-G Antigens / genetics
TL;DR:
AAV-mediated gene transfer of HLA-G may be an effective treatment for common immune-mediated, inflammatory, and neovascular diseases of the eye.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 28, 2022
2022 chapter
Vision and vision disorders in performance horses
In K. W. Hinchcliff, A. J. Kaneps, R. J. Geor, & E. van Erck-Westergen (Eds.), Equine sports medicine and surgery : basic and clinical sciences of the equine athlete. (3rd ed.). Philadelphia, PA: Saunders.
Ed(s): K. Hinchcliff, A. Kaneps, R. Geor & E. van Erck-Westergen
Source: NC State University Libraries
Added: February 2, 2024
2021 journal article
A defect in the NOG gene increases susceptibility to spontaneous superficial chronic corneal epithelial defects (SCCED) in boxer dogs
BMC Veterinary Research, 17(1).
author keywords: Corneal ulcer; Chronic; Superficial; Recurrent erosion; NOG; Boxer
MeSH headings : Animals; Bone Morphogenetic Proteins / genetics; Bone Morphogenetic Proteins / metabolism; Chronic Disease; Corneal Diseases / veterinary; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Epithelium, Corneal / pathology; Gene Expression Regulation; Genetic Predisposition to Disease; Whole Genome Sequencing
TL;DR:
Many Boxer dogs with SCCED have a genetic defect in NOG, a constitutive protein in the cornea which is a potent inhibitor of BMP, which likely regulate limbal epithelial progenitor cells (LEPC).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 9, 2021
2021 journal article
Efficacy and safety of suprachoroidal triamcinolone injection in horses with poorly responsive equine recurrent uveitis
Veterinary Ophthalmology, 24(3), 308–312.
author keywords: horse; recurrent; retrospective; suprachoroidal; triamcinolone; uveitis
MeSH headings : Animals; Anti-Inflammatory Agents / administration & dosage; Anti-Inflammatory Agents / therapeutic use; Choroid; Female; Horse Diseases / drug therapy; Horses; Injections / veterinary; Male; Records / veterinary; Recurrence; Retrospective Studies; Treatment Outcome; Triamcinolone / administration & dosage; Triamcinolone / therapeutic use; Uveitis / drug therapy; Uveitis / veterinary
TL;DR:
SCS TA injections appear to be a safe and possible effective treatment modality for managing poorly responsive ERU; further clinical study is warranted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: April 1, 2021
2021 personal communication
Response to comments on 'Whole-genome sequencing identifies missense mutation in GRM6 as the likely cause of congenital stationary night blindness in a Tennessee Walking Horse'
Gilger, B., & Bellone, R. R. (2021, November).
MeSH headings : Animals; Eye Diseases, Hereditary / veterinary; Genetic Diseases, X-Linked; Horse Diseases / genetics; Horses; Mutation, Missense; Myopia; Night Blindness / genetics; Night Blindness / veterinary; Tennessee
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 18, 2021
2021 journal article
Role of <i>Leptospira</i> spp. testing and ocular examination in horses with equine recurrent uveitis: A retrospective study of 63 horses
Equine Veterinary Education, 34(11).
author keywords: horse; uveitis; leptospirosis; titres; PCR
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 30, 2021
2021 journal article
Tolerability, pharmacokinetics, and pharmacodynamics of a brinzolamide episcleral sustained release implant in normotensive New Zealand white rabbits
Journal of Drug Delivery Science and Technology, 61, 102123.
author keywords: Glaucoma; Sustained-release; Episcleral; Brinzolamide; Rabbit; Tolerability
TL;DR:
Episcleral brinzolamide-loaded silicone-matrix implants were extremely well tolerated and delivered sustained drug levels and therapeutic effect for up to 28 days in a rabbit model with an estimated duration of delivery of greater than 12 months.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: September 29, 2020
2021 book
Veterinary Ophthalmology
(6th ed.). Hoboken, NJ: Wiley.
Source: NC State University Libraries
Added: February 2, 2024
2020 chapter
Acquired ocular disease in foals – the first 30 days
In Foal Diseases.
Source: NC State University Libraries
Added: February 2, 2024
2020 journal article
Adeno-Associated Virus Mediated Gene Therapy for Corneal Diseases
Pharmaceutics, 12(8), 767.
author keywords: adeno-associated viruses; cornea; corneal diseases; AAV gene therapy; rAAV
TL;DR:
This current review seeks to summarize the development of AAV gene therapy, highlight preclinical efficacy studies, and discuss potential applications and challenges of this technology for targeting corneal diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: September 14, 2020
2020 journal article
Improving Corneal Wound Healing after Chemical Injury with Novel Therapeutic Glycopolymers
Toxicology Letters, 331, 16.
Sources: Web Of Science, NC State University Libraries, Crossref
Added: November 16, 2020
2020 journal article
In vitro susceptibility of <i>Aspergillus</i> and <i>Fusarium</i> associated with equine keratitis to new antifungal drugs
Veterinary Ophthalmology, 23(5), 918–922.
author keywords: Aspergillus; Fusarium; luliconazole; voriconazole
MeSH headings : Animals; Antifungal Agents / pharmacology; Antifungal Agents / therapeutic use; Aspergillus / drug effects; Eye Infections, Fungal / drug therapy; Eye Infections, Fungal / microbiology; Eye Infections, Fungal / veterinary; Female; Fusarium / drug effects; Horse Diseases / drug therapy; Horse Diseases / microbiology; Horses; Imidazoles / pharmacology; Imidazoles / therapeutic use; Keratitis / drug therapy; Keratitis / microbiology; Keratitis / veterinary; Male; Microbial Sensitivity Tests
TL;DR:
Luliconazole exhibited increased growth inhibition against both Aspergillus and Fusarium compared to commonly used, standard antifungal drugs, and warrants further investigation for its potential as an antIFungal drug for equine fungal keratitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries
Added: May 17, 2020
2020 journal article
Intrastromal Gene Therapy Prevents and Reverses Advanced Corneal Clouding in a Canine Model of Mucopolysaccharidosis I
MOLECULAR THERAPY, 28(6), 1455–1463.
MeSH headings : Animals; Animals, Genetically Modified; Corneal Diseases / diagnosis; Corneal Diseases / etiology; Corneal Diseases / therapy; Dependovirus / genetics; Disease Models, Animal; Dogs; Female; Fluorescent Antibody Technique; Gene Expression; Gene Knockdown Techniques; Gene Transfer Techniques; Genes, Reporter; Genetic Therapy / methods; Genetic Vectors / administration & dosage; Genetic Vectors / genetics; Iduronidase / genetics; Male; Mucopolysaccharidosis I / complications; Mucopolysaccharidosis I / genetics; Transgenes; Treatment Outcome
TL;DR:
Results suggest that intrastromal AAV8G9-IDUA therapy prevents and reverses visual impairment associated with MPS I corneal clouding.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 29, 2020
2020 journal article
Ocular Tolerability and Immune Response to Corneal Intrastromal AAV-IDUA Gene Therapy in New Zealand White Rabbits
Molecular Therapy - Methods & Clinical Development, 18, 24–32.
TL;DR:
It is suggested that AAV-opt-IDUA corneal gene therapy following corneAL intrastromal injection of AAV, shown to be effective in mucopolysaccharidosis type I (MPS I) dogs, has the potential to prevent and reverse blindness in MPS I patients in a safe and effective manner.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: September 28, 2020
2020 chapter
Ocular diseases of the Order Perissodactyla: Wild horses, Zebras, Tapirs, Rhinoceros
In K. N. Gelatt (Ed.), Veterinary Ophthalmology (6th edition). Hoboken, NJ: Wiley-Blackwell.
Ed(s): K. Gelatt
Source: NC State University Libraries
Added: October 20, 2020
2020 journal article
Optimizing corneal riboflavin administration in ex vivo horse, dog, rabbit, and pig samples for use in corneal collagen cross‐linking
Veterinary Ophthalmology, 23(5), 840–848.
author keywords: cornea; cross-linking; equine; iontophoresis; PCI needles; riboflavin
MeSH headings : Animals; Collagen / drug effects; Cornea / drug effects; Dogs; Horses; Injections / veterinary; Iontophoresis / veterinary; Ophthalmic Solutions / administration & dosage; Ophthalmic Solutions / pharmacology; Photosensitizing Agents / administration & dosage; Photosensitizing Agents / pharmacology; Rabbits; Riboflavin / administration & dosage; Riboflavin / pharmacology; Species Specificity; Swine
TL;DR:
Both iontophoresis and injection via PCI needles provide efficient and effective means of riboflavin administration in ex vivo horse, dog, rabbit, and pig corneas.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: July 24, 2020
2020 journal article
Polymer-mediated delivery of vaccines to treat opioid use disorders and to reduce opioid-induced toxicity
VACCINE, 38(30), 4704–4712.
author keywords: Opioid; Vaccine; Polymer; Formulation; Antibody; Adjuvant
MeSH headings : Analgesics, Opioid / toxicity; Animals; Mice; Opioid-Related Disorders / drug therapy; Oxycodone / therapeutic use; Polymers; Rats; Vaccines / therapeutic use
TL;DR:
Polymer-based delivery of the anti-oxycodone vaccine was equally or more effective than administration in aluminum adjuvant in generating oxycodone-specific antibodies and in reducing oxy codone-induced effects and oxyCodone distribution to the brain in mice and rats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 29, 2020
2020 journal article
Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles
Nature Communications, 11(1), 694.
MeSH headings : Animals; Choroidal Neovascularization / drug therapy; Choroidal Neovascularization / genetics; Choroidal Neovascularization / metabolism; Female; Humans; Male; Mice; Mice, Inbred C57BL; Rabbits; Receptors, Vascular Endothelial Growth Factor / antagonists & inhibitors; Receptors, Vascular Endothelial Growth Factor / genetics; Receptors, Vascular Endothelial Growth Factor / metabolism; Retinal Diseases / drug therapy; Retinal Diseases / genetics; Retinal Diseases / metabolism; Sunitinib / administration & dosage; Sunitinib / chemistry; Sunitinib / pharmacokinetics; Swine; Swine, Miniature; Vascular Endothelial Growth Factor A / genetics; Vascular Endothelial Growth Factor A / metabolism
TL;DR:
A microparticle-loaded tyrosine kinase inhibitor therapy is developed, which is effective for six months after a single injection in preclinical models, and provides a promising approach to achieve sustained suppression of VEGF signaling and improve outcomes in patients with retinal vascular diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: October 20, 2020
2020 journal article
Whole-genome sequencing identifies missense mutation inGRM6as the likely cause of congenital stationary night blindness in a Tennessee Walking Horse
EQUINE VETERINARY JOURNAL, 53(2), 316–323.
author keywords: horse; congenital stationary night blindness (CSNB); genetics; genomics; Tennessee Walking Horse; GRM6
MeSH headings : Animals; Eye Diseases, Hereditary / genetics; Eye Diseases, Hereditary / veterinary; Genetic Diseases, X-Linked; Horse Diseases / genetics; Horses; Mutation, Missense; Myopia; Night Blindness / genetics; Night Blindness / veterinary; Receptors, Glutamate / genetics; Tennessee
TL;DR:
A likely causal recessive missense variant in metabotropic glutamate receptor 6 (GRM6) is identified, which alters GRM6 binding, and thus signaling from the retinal rod cell to the ON-bipolar cell, impairing vision in low light conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 17, 2020
2019 journal article
A Fixed-Depth Microneedle Enhances Reproducibility and Safety for Corneal Gene Therapy
CORNEA, 39(3), 362–369.
author keywords: cornea; stromal; gene therapy; safety
MeSH headings : Animals; Corneal Stroma / metabolism; Dependovirus / genetics; Gene Expression; Gene Transfer Techniques; Genetic Therapy / methods; Genetic Vectors; Green Fluorescent Proteins / genetics; Injections, Intraocular; Male; Microscopy, Confocal; Needles; Rabbits; Reproducibility of Results; Swine; Ultrasonography
TL;DR:
This research presents a novel probabilistic approach that allows us to assess the importance of knowing the carrier and removal status of canine coronavirus as a source of infection in animals and its role in the immune system is investigated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 18, 2020
2019 journal article
A Transient Developmental Background Finding in the Retina Observed in Neonatal Dogs in Juvenile Toxicology Studies
Toxicologic Pathology, 47(4), 528–541.
author keywords: retina; neonatal dog; juvenile dog; juvenile toxicology; beagle dog; ocular development
MeSH headings : Age Factors; Animals; Animals, Newborn; Dogs; Fluorescein Angiography; Microscopy; Microscopy, Electron, Transmission; Retina / diagnostic imaging; Retina / growth & development; Tomography, Optical Coherence; Toxicology / methods; Vacuoles / physiology
TL;DR:
In a juvenile toxicology program, an unexpected finding of vacuolation of inner nuclear, ganglion cell, and nerve fiber layers of the retina was observed microscopically in routine Davidson's fixed and hematoxylin and eosin–stained tissue sections of eyes in beagle dogs at approximately 5 weeks of age.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: July 22, 2019
2019 journal article
AAV-mediated expression of HLA-G1/5 reduces severity of experimental autoimmune uveitis
Scientific Reports, 9(1), 19864.
MeSH headings : Animals; Antibodies, Neutralizing / metabolism; Dependovirus / genetics; Female; Genetic Therapy; HLA-G Antigens / genetics; HLA-G Antigens / metabolism; HLA-G Antigens / physiology; Intravitreal Injections; Rats; Uveitis / genetics; Uveitis / metabolism; Uveitis / pathology; Uveitis / therapy
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: February 10, 2020
2019 journal article
Evaluation of equine corneal disease using spectral domain optical coherence tomography (SD-OCT)
Veterinary Ophthalmology, 2.
author keywords: cornea; equine; keratitis; optical coherence tomography
MeSH headings : Animals; Corneal Diseases / diagnosis; Corneal Diseases / pathology; Corneal Diseases / veterinary; Female; Horse Diseases / diagnosis; Horse Diseases / pathology; Horses; Male; Retrospective Studies; Tomography, Optical Coherence / methods; Tomography, Optical Coherence / veterinary
TL;DR:
Results from this retrospective study suggest that handheld SD-OCT for imaging the cornea of horses is feasible and may be helpful in determining depth and extent of lesions in the Cornea.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 9, 2019
2019 journal article
Multi-locus DNA sequence analysis, antifungal agent susceptibility, and fungal keratitis outcome in horses from Southeastern United States
PLOS ONE, 14(3), e0214214.
Ed(s): O. Kniemeyer
MeSH headings : Animals; Antifungal Agents / pharmacology; Eye Infections, Fungal / drug therapy; Eye Infections, Fungal / microbiology; Eye Infections, Fungal / veterinary; Horse Diseases / drug therapy; Horse Diseases / microbiology; Horses; Keratitis / drug therapy; Keratitis / microbiology; Keratitis / veterinary; Southeastern United States; Species Specificity; Thiabendazole / pharmacology
TL;DR:
The results of this study suggest that treatment of equine FK with antifungal agents requires accurate fungal species identification, and demonstrate the importance of fungal identification to the species rather than genus level.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: April 15, 2019
2019 chapter
Ocular diseases of the Order Perissodactyla: Wild horses, Zebras, Tapirs, Rhinoceros
In G. Schlomo (Ed.), Exotic Animal Ophthalmology.
Ed(s): G. Schlomo
Source: NC State University Libraries
Added: February 2, 2024
2019 journal article
Subconjunctival bone marrow‐derived mesenchymal stem cell therapy as a novel treatment alternative for equine immune‐mediated keratitis: A case series
Veterinary Ophthalmology, 22(5), 674–682.
author keywords: bone marrow-derived mesenchymal stem cells; cornea; equine; immune-mediated keratitis; immunomodulating therapy; subconjunctival therapy
MeSH headings : Animals; Female; Horse Diseases / therapy; Horses; Keratitis / therapy; Keratitis / veterinary; Male; Mesenchymal Stem Cell Transplantation / veterinary; Treatment Outcome
TL;DR:
Experimental results demonstrate the safety and potential efficacy of an innovative solution for IMMK and show that bone marrow-derived mesenchymal stem cells have the potential to modulate the immune system by downregulating inflammation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 9, 2019
2018 journal article
Factors associated with postoperative complications in healthy horses after general anesthesia for ophthalmic versus non-ophthalmic procedures: 556 cases (2012–2014)
Journal of the American Veterinary Medical Association, 252(9), 1113–1119.
MeSH headings : Anesthesia Recovery Period; Anesthesia, General / veterinary; Animals; Colic / veterinary; Eye Diseases / surgery; Eye Diseases / veterinary; Female; Horse Diseases / surgery; Horses; Male; Ophthalmologic Surgical Procedures / veterinary; Postoperative Complications / veterinary; Records / veterinary; Treatment Outcome
TL;DR:
In healthy horses, duration of general anesthesia should be minimized to decrease the risk of postanesthetic complications, and judicious use of orally administered fluconazole is recommended.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2018 journal article
Immune Relevant Models for Ocular Inflammatory Diseases
ILAR Journal, 2.
author keywords: animal models; dry eye; immune-relevant; inflammatory; naturally-occurring; ocular; uveitis
MeSH headings : Animals; Disease Models, Animal; Eye Diseases / immunology; Inflammation / immunology; Uveitis / immunology
TL;DR:
The purpose of this review is to describe common immune-relevant models of dry eye and uveitis with an overview of the immuno-pathogenesis of each disease and reported evaluation of models from small to large animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 9, 2019
2018 journal article
Nonclinical Development of ENV905 (Difluprednate) Ophthalmic Implant for the Treatment of Inflammation and Pain Associated with Ocular Surgery
Journal of Ocular Pharmacology and Therapeutics, 34(1-2), 161–169.
author keywords: difluprednate; intracameral; corticosteroid; ENV905; subconjunctival
MeSH headings : Animals; Cataract Extraction / adverse effects; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Delivery Systems; Female; Fluprednisolone / administration & dosage; Fluprednisolone / analogs & derivatives; Fluprednisolone / chemistry; Fluprednisolone / therapeutic use; Inflammation / drug therapy; Injections, Intraocular; Ophthalmic Solutions / administration & dosage; Ophthalmic Solutions / chemistry; Ophthalmic Solutions / therapeutic use; Pain, Postoperative / drug therapy; Rabbits
TL;DR:
ENV905 was well tolerated and demonstrated a robust reduction in ocular inflammation with targeted drug delivery, and shows that ENV905 provides a sustained therapeutic effect after a single dose.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019
2018 journal article
Serotype survey of AAV gene delivery via subconjunctival injection in mice
Gene Therapy, 25(6), 402–414.
MeSH headings : Animals; Conjunctiva / pathology; Cornea / metabolism; Cornea / pathology; Cornea / virology; Dependovirus / genetics; Eye Diseases / genetics; Eye Diseases / pathology; Eye Diseases / therapy; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors / genetics; Genetic Vectors / immunology; Green Fluorescent Proteins / genetics; Humans; Mice; Serogroup; Surveys and Questionnaires; Transduction, Genetic
TL;DR:
Subconjunctival administration of particular AAV serotypes may be a simple and safe targeted gene delivery route for ocular surface, muscular, corneal, and optic nerve diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: October 16, 2018
2018 chapter
Spontaneous Incidence of Ocular Abnormalities in Laboratory Animals
In Standards for Ocular Toxicology and Inflammation (pp. 141–168).
TL;DR:
This chapter provides incidence data on spontaneous ophthalmic abnormalities in the most commonly used species in toxicological and pharmacokinetic drug research to improve speed of drug development, reduce the number of studies that need to be repeated, and thus reduce the overall number of animals used in toxicology research and drug development.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019
2018 chapter
Standard Operating Procedures for Common Laboratory Animal Ocular Procedures
In Standards for Ocular Toxicology and Inflammation (pp. 27–44).
TL;DR:
This chapter provides a basis for researchers, contract research laboratories, or other investigators to develop harmonized protocols for commonly performed ophthalmic procedures in laboratory animals and to assist in development of institutional standard operating procedure (SOP) documentation.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019
2018 chapter
Standards for Conducting Ophthalmic Examinations in Laboratory Animals
In Standards for Ocular Toxicology and Inflammation (pp. 1–25).
TL;DR:
The ophthalmologist must beamiliar with the wide range of species used in the field of toxicology, be familiar with the anatomic variations associated with these species, be able to differentiate an inherited or a breed-related finding from a study-related effect, be competent with the required ophthalmic equipment, and be capable of examining this widerange of animals.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019
2018 book
Standards in Ocular Toxicology and Inflammation
Cham, Switzerland: Springer.
Source: NC State University Libraries
Added: October 20, 2020
2017 journal article
AAV vector-meditated expression of HLA-G reduces injury-induced corneal vascularization, immune cell infiltration, and fibrosis
Scientific Reports, 7(1).
MeSH headings : Animals; Corneal Injuries / genetics; Corneal Injuries / metabolism; Corneal Injuries / pathology; Corneal Injuries / therapy; Corneal Neovascularization / genetics; Corneal Neovascularization / metabolism; Corneal Neovascularization / pathology; Corneal Neovascularization / therapy; Dependovirus; Gene Expression; Genetic Therapy; HEK293 Cells; HLA-G Antigens / biosynthesis; HLA-G Antigens / genetics; Humans; Rabbits
TL;DR:
The collective data demonstrate the clinical potential of scAAV8G9-optHLA-G to safely and effectively treat corneal vascularization and inhibit fibrosis while alluding to broader roles in ocular surface immunity and allogenic organ transplantation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2017 journal article
Advanced Imaging of the Equine Eye
Veterinary Clinics of North America: Equine Practice, 33(3), 607–626.
author keywords: Equine; Eye; Imaging; Ultrasound; Computed tomography; MRI; Optical coherence tomography; Confocal microscopy
MeSH headings : Animals; Eye / diagnostic imaging; Horses / anatomy & histology; Magnetic Resonance Imaging / veterinary; Tomography, Optical Coherence / veterinary; Tomography, X-Ray Computed / veterinary; Ultrasonography / veterinary
TL;DR:
The literature for studies describing advanced imaging of the equine eye as a reference for practitioners to help in the selection of image modalities, describe how to use the instruments, and help interpret the image findings are reviewed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
2017 journal article
Effect of bone marrow-derived mesenchymal stem cells and stem cell supernatant on equine corneal wound healing in vitro
Stem Cell Research & Therapy, 8(1).
author keywords: Mesenchymal stem cells; Equine; Corneal wound healing; Corneal stromal cells/fibroblasts; Scratch assay; TGF-beta 1
MeSH headings : Animals; Biomarkers / metabolism; Bone Marrow Cells / cytology; Corneal Injuries / pathology; Corneal Injuries / therapy; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor / metabolism; Female; Flow Cytometry; Horses; Male; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Transforming Growth Factor beta1 / metabolism; Wound Healing
TL;DR:
The significant decrease in scratch area in equine corneal fibroblast cultures treated with autologous BM-MSCs compared to MSC-Sp or control treatments suggests that BM- MSCs may substantially improve corNEal wound healing in horses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2017 journal article
Evaluation of Intracameral Pentablock Copolymer Thermosensitive Gel for Sustained Drug Delivery to the Anterior Chamber of the Eye
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, 33(5), 353–360.
author keywords: ocular; sustained drug delivery; intracameral; pentablock; copolymer
MeSH headings : Animals; Anterior Chamber / drug effects; Anterior Chamber / metabolism; Drug Delivery Systems; Drug Tolerance; Gels / administration & dosage; Gels / pharmacokinetics; Injections, Intraocular; Polymers / administration & dosage; Polymers / pharmacokinetics; Rabbits; Temperature
TL;DR:
The results demonstrate the potential of intracameral PTSgel formulations for sustained delivery of biologic therapies to the ocular anterior segment and drug release profile, tolerability, and polymer degradation for one of the thermosensitive, biodegradable, and biocompatible compositions were investigated through intracAMeral injection in rabbits.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Evaluation of pentablock co-polymer (PTS sol ) for sustained topical ocular drug delivery
Journal of Drug Delivery Science and Technology, 39, 475–483.
author keywords: Ocular; Sustained drug delivery; Pentablock co-polymers; Hydrophobic drugs; Brinzolamide; Hydrophilic drugs
TL;DR:
Ocular retention, tolerability, and sustained pharmacodynamics of a clear topical formulation of brinzolamide (BRZ) in PTS sol pentablock co-polymer suggest that drugs in PTSsol may allow for once a day or less frequent dosing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2017 journal article
Optic neuritis in dogs: 96 cases (1983-2016)
Veterinary Ophthalmology, 21(5), 442–451.
author keywords: causes of canine optic neuritis; dogs; granulomatous meningoencephalitis; meningoencephalitis of unknown etiology; ocular GME; optic neuritis
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / epidemiology; Dog Diseases / etiology; Dog Diseases / therapy; Dogs; Female; Magnetic Resonance Imaging; Male; Medical Records; Meningoencephalitis / complications; Meningoencephalitis / veterinary; North Carolina / epidemiology; Optic Neuritis / epidemiology; Optic Neuritis / veterinary
TL;DR:
Optic neuritis was most commonly associated with multifocal MUE or was isolated as the sole neurologic finding, with a similar incidence between the two groups.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: November 12, 2018
2016 journal article
544. Comparison of AAV Serotype2 Transduction by Various Delivery Routes to the Mouse Eye
Molecular Therapy, 24, S217–S218.
TL;DR:
The transduction of multiple retinal layers throughout the retina without the damage of retinal detachment and widespread distribution makes suprachoroidal injections a better delivery route than to subretinal injection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
2016 journal article
AAV Gene Therapy for MPS1-associated Corneal Blindness
Scientific Reports, 6(1).
MeSH headings : Apoptosis / genetics; Blindness / enzymology; Blindness / genetics; Blindness / therapy; Blotting, Western; Cells, Cultured; Cornea / metabolism; Cornea / pathology; Corneal Diseases / enzymology; Corneal Diseases / genetics; Corneal Diseases / therapy; Dependovirus / genetics; Fibroblasts / cytology; Fibroblasts / metabolism; Genetic Therapy / methods; Genetic Vectors / genetics; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; HEK293 Cells; Humans; Iduronidase / genetics; Iduronidase / metabolism; Microscopy, Confocal; Mucopolysaccharidosis I / enzymology; Mucopolysaccharidosis I / genetics; Mucopolysaccharidosis I / therapy; Organ Culture Techniques; Transfection / methods
TL;DR:
The collective preclinical data demonstrate safe and efficient IDUA delivery to human corneas, which may prevent and potentially reverse MPS1-associated cornea blindness.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019
2016 article
Association of acute leptospirosis with systemic disease and uveitis in horses
Gilger, B. C. (2018, March). EQUINE VETERINARY EDUCATION, Vol. 30, pp. 137–138.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Best practice recommendations for prehospital veterinary care of dogs and cats
Journal of Veterinary Emergency and Critical Care, 26(2), 166–233.
author keywords: cat; dog; first response; trauma; VetCOT
MeSH headings : Animals; Cats; Consensus; Databases, Factual; Dogs; Emergency Service, Hospital / standards; Practice Guidelines as Topic; Practice Management, Veterinary / standards; United States; Veterinary Medicine / standards; Wounds and Injuries / therapy; Wounds and Injuries / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2016 journal article
Cytokine and chemokine profiles of aqueous humor and serum in horses with uveitis measured using multiplex bead immunoassay analysis
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 182, 43–51.
author keywords: Uveitis; Multiplex; Horse; Cytokine; Chemokine; Leptospirosis
MeSH headings : Animals; Aqueous Humor / immunology; Biomarkers / blood; Biomarkers / metabolism; Chemokines / blood; Chemokines / metabolism; Cytokines / blood; Cytokines / metabolism; Horse Diseases / blood; Horse Diseases / diagnosis; Horse Diseases / immunology; Horses; Immunoassay; Inflammation Mediators / blood; Inflammation Mediators / metabolism; Leptospirosis / blood; Leptospirosis / immunology; Leptospirosis / veterinary; Uveitis / blood; Uveitis / immunology; Uveitis / veterinary
TL;DR:
The anti-inflammatory cytokine IL-10 and the pro- inflammatory cytokine IP-10 appear to play an important role in ERU.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 book
TL;DR:
This review is intended to describe briefly some of the medications, techniques, and devices currently employed in equine ophthalmology that will provide a foundation for the sound management of ocular disease.
(via Semantic Scholar)
Source: ORCID
Added: September 9, 2019
2016 chapter
Equine ocular examination basic techniques
In B. Gilger (Ed.), Equine Ophthalmology (pp. 1–39).
Sources: Crossref, NC State University Libraries
Added: January 29, 2024
2016 journal article
Histiocytic chorioretinitis in a dog
Veterinary Ophthalmology, 21(1), 88–95.
author keywords: canine; chorioretinitis; histiocytic; Melan-A; melanoma; retinal detachment
MeSH headings : Animals; Chorioretinitis / diagnosis; Chorioretinitis / veterinary; Diagnosis, Differential; Diagnostic Techniques, Ophthalmological; Dog Diseases / diagnosis; Dogs; Eye Enucleation; Male
TL;DR:
A 3-year-old castrated male mixed-breed dog presented with an acute bullous retinal detachment and thickened choroid of the right eye, which caused a revision of the histologic diagnosis from melanocytic tumor to histiocytic chorioretinitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2016 journal article
Impact of fungal species cultured on outcome in horses with fungal keratitis
Veterinary Ophthalmology, 20(2), 140–146.
author keywords: Aspergillus spp.; cornea; equine; fungal culture; Fusarium spp.; keratomycosis
MeSH headings : Animals; Antifungal Agents / therapeutic use; Aspergillosis / drug therapy; Aspergillosis / veterinary; Aspergillus; Eye Infections, Bacterial / drug therapy; Eye Infections, Bacterial / veterinary; Eye Infections, Fungal / drug therapy; Eye Infections, Fungal / microbiology; Eye Infections, Fungal / veterinary; Female; Fusariosis / drug therapy; Fusariosis / veterinary; Fusarium; Horse Diseases / drug therapy; Horse Diseases / microbiology; Horses; Keratitis / drug therapy; Keratitis / microbiology; Keratitis / veterinary; Male; Retrospective Studies; Steroids / therapeutic use; Treatment Outcome
TL;DR:
Genus of fungus cultured was not significantly associated with the need for surgical intervention nor was it significantlyassociated with the necessity of globe-sparing surgery versus enucleation, and bacterial co-infection, previous topical steroidal or antifungal use, and time of year did not affect outcome or type of fungal species cultured.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2016 chapter
Recurrent uveitis
In M. J. B. Felippe (Ed.), Equine Clinical Immunology. Ames, Iowa: Wiley Blackwell.
Ed(s): M. Felippe
Source: NC State University Libraries
Added: October 19, 2020
2016 journal article
Sustained Release of Protein Therapeutics from Subcutaneous Thermosensitive Biocompatible and Biodegradable Pentablock Copolymers (PTSgels)
JOURNAL OF DRUG DELIVERY, 2016.
TL;DR:
Subcutaneous PTSgels were highly biocompatible and in vitro IgG release occurred in parallel with the disappearance of subcutaneous gel in vivo, and modulation of release of biologics to fit the therapeutic need can be achieved by varying the biocombatible and biodegradable PTSgel composition.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 article
Topical delivery of aqueous micellar Resolvin E1 analog (RX-10045) (vol 498, pg 326, 2016)
Cholkar, K., Gilger, B. C., & Mitra, A. K. (2016, July 25). INTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol. 509, pp. 528–528.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Causes of endogenous uveitis in cats presented to referral clinics in North Carolina
Veterinary Ophthalmology, 19, 30–37.
author keywords: causes; endogenous uveitis; feline uveitis; prevalence
MeSH headings : Animals; Cat Diseases / epidemiology; Cat Diseases / etiology; Cat Diseases / microbiology; Cat Diseases / virology; Cats; Female; Male; Neoplasms / complications; Neoplasms / veterinary; North Carolina / epidemiology; Uveitis / etiology; Uveitis / microbiology; Uveitis / veterinary; Uveitis / virology
TL;DR:
Because of the high prevalence of FIP, young cats with uveitis should be evaluated for hyperglobulinemia and FCoV serology should be performed as minimal diagnostics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Equine eosinophilic keratitis in horses: 28 cases (2003-2013)
Clinical Case Reports, 3(12), 1000–1006.
author keywords: Eosinophilic conjunctivitis; eosinophilic keratitis; eosinophilic keratoconjuctivitis; equine
TL;DR:
This retrospective case series evaluates husbandry and environmental conditions in relation to eosinophilic keratitis in horses to identify an increased prevalence of presentation in summer months.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 24, 2020
2015 chapter
Ocular Trauma
In E. Robinson & K. Sprayberry (Eds.), Robinson's Current Therapy in Equine Medicine (Vol. 7, pp. 39–44).
Ed(s): E. Robinson & K. Sprayberry
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: September 9, 2019
2015 journal article
Phacoemulsification and aspiration for cataract management in a dollar sunfish,Lepomis marginatus(Holbrook) - a case report
Journal of Fish Diseases, 38(12), 1089–1092.
author keywords: cataract; dollar sunfish; extracapsular lens extraction; Lepomis marginatus; phacoemulsification
MeSH headings : Animals; Cataract / therapy; Cataract / veterinary; Fish Diseases / therapy; Male; Perciformes; Phacoemulsification / methods; Phacoemulsification / veterinary; Suction / methods; Suction / veterinary
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Presumed primary ocular lymphangiosarcoma with metastasis in a miniature horse
Veterinary Ophthalmology, 18(6), 502–509.
author keywords: histopathology; horse; immunohistochemistry; lymphangiosarcoma; metastatic; ocular
MeSH headings : Animals; Corneal Diseases / diagnosis; Corneal Diseases / pathology; Corneal Diseases / therapy; Corneal Diseases / veterinary; Eye Neoplasms / diagnosis; Eye Neoplasms / pathology; Eye Neoplasms / therapy; Eye Neoplasms / veterinary; Fatal Outcome; Female; Horse Diseases / diagnosis; Horse Diseases / pathology; Horses; Lymphangiosarcoma / diagnosis; Lymphangiosarcoma / pathology; Lymphangiosarcoma / therapy; Lymphangiosarcoma / veterinary
TL;DR:
A 7-year-old, 153.0-kg American Miniature mare presented for evaluation of keratoconjunctivitis of the right eye (OD), and a primary ocular lymphangiosarcoma with metastasis was diagnosed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Prognosis and impact of equine recurrent uveitis
Equine Veterinary Journal, 48(3), 290–298.
author keywords: horse; recurrent; uveitis; retrospective; outcome; leptospirosis
MeSH headings : Animals; Female; Horse Diseases / epidemiology; Horse Diseases / pathology; Horse Diseases / therapy; Horses; Male; Retrospective Studies; Risk Factors; Southeastern United States; Uveitis / epidemiology; Uveitis / pathology; Uveitis / therapy; Uveitis / veterinary
TL;DR:
The impact of ERU is attributed to the high frequency of blindness, globe loss and loss of function, along with financial costs of the disease, which have a significant impact on affected horses and their owners.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 article
Recurrent Uveitis
Gilger, B. C. (2015, November 6). Equine Clinical Immunology, Vol. 11, pp. 121–126.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Retrobulbar pigmented peripheral nerve sheath tumor in a dog
Veterinary Ophthalmology, 19(6), 518–524.
author keywords: exophthalmos; peripheral nerve sheath tumor; pigmented; pug; retrobulbar; sarcoma
MeSH headings : Animals; Dog Diseases / pathology; Dogs; Exophthalmos; Male; Nerve Sheath Neoplasms / pathology; Nerve Sheath Neoplasms / veterinary; Orbit; Quality of Life; Tomography, X-Ray Computed
TL;DR:
A 1-year-old male castrated Pug was referred for unilateral exophthalmos unresponsive to oral antibiotic and anti-inflammatory therapy; the patient was euthanized 13 weeks following exenteration due to development of neurologic signs and perceived poor quality of life.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Topical delivery of aqueous micellar resolvin E1 analog (RX-10045)
International Journal of Pharmaceutics, 498(1-2), 326–334.
author keywords: Aqueous; Formulation; Micelles; Resolving; Inflammation; Sclera; Drug delivery; Back-of-the-eye; Posterior; Topical; Eye drop; Retina/choroid; Rabbits
MeSH headings : Administration, Ophthalmic; Administration, Topical; Animals; Drug Delivery Systems / methods; Eicosapentaenoic Acid / administration & dosage; Eicosapentaenoic Acid / analogs & derivatives; Eicosapentaenoic Acid / chemistry; Eicosapentaenoic Acid / metabolism; Female; Micelles; Rabbits; Solubility; Tissue Distribution / drug effects; Tissue Distribution / physiology; Vitreous Body / drug effects; Vitreous Body / metabolism; Water / chemistry
TL;DR:
Micelles appear to follow conjunctival/scleral pathway to reach back-of-the-eye tissue (retina) and topical aqueous formulations may be employed to treat posterior ocular diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2015 journal article
Topical, Aqueous, Clear Cyclosporine Formulation Design for Anterior and Posterior Ocular Delivery
Translational Vision Science & Technology, 4(3), 1.
author keywords: nanomicelles; formulation; cyclosporine; sclera; drug delivery; drops; back of the eye; posterior; topical; retina/choroid; rabbits; dry eye
TL;DR:
Results suggest that aqueous nanomicellar approach can provide high corneal and conjunctival CsA concentrations and suggest polymeric blend to be a safe carrier for anterior and posterior ocular tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019
2014 journal article
Clinical, histopathological and immunohistochemical characterization of a novel equine ocular disorder: heterochromic iridocyclitis with secondary keratitis in adult horses
VETERINARY OPHTHALMOLOGY, 18(6), 443–456.
author keywords: endotheliitis; iridocyclitis; keratic precipitates; keratitis; retrocorneal membrane; uveitis
MeSH headings : Animals; Cornea / pathology; Female; Horse Diseases / diagnosis; Horse Diseases / pathology; Horses; Iridocyclitis / diagnosis; Iridocyclitis / pathology; Iridocyclitis / veterinary; Keratitis / diagnosis; Keratitis / pathology; Keratitis / veterinary; Male; Uvea / pathology
TL;DR:
Heterochromic iridocyclitis with secondary keratitis (HIK) is characterized by uveal inflammation with pigment dispersion and suspected corneal endothelial dysfunction and may not respond to therapy and enucleation may ultimately be required to ensure the horse's comfort.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Efficacy of cox-2 inhibitors in controlling inflammation and capsular opacification after phacoemulsification cataract removal
Veterinary Ophthalmology, 18(3), 175–185.
author keywords: Bromfenac; celecoxib; intraocular lens implant; posterior capsule opacification; phacoemulsification; prednisolone acetate
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Benzophenones / therapeutic use; Bromobenzenes / therapeutic use; Celecoxib / administration & dosage; Celecoxib / therapeutic use; Cyclooxygenase 2 Inhibitors / administration & dosage; Cyclooxygenase 2 Inhibitors / therapeutic use; Dog Diseases / therapy; Dogs; Inflammation / prevention & control; Inflammation / veterinary; Intraocular Pressure; Lenses, Intraocular / veterinary; Phacoemulsification / adverse effects; Phacoemulsification / veterinary; Prednisolone / administration & dosage; Prednisolone / analogs & derivatives; Prednisolone / therapeutic use
TL;DR:
Eyes receiving celecoxib-IOL/PA had better initial control of inflammation and bromfenac had better long-term control of PCO, and there was no association between COX-2 inhibitor administration and ocular hypertension.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Episcleral, Intrascleral, and Suprachoroidal Routes of Ocular Drug Delivery - Recent Research Advances and Patents
Recent Patents on Drug Delivery & Formulation, 8(2), 81–91.
TL;DR:
This manuscript will review the recent research advances and patents on episcleral, intrasCleral, and suprachoroidal routes of ocular drug delivery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 15, 2024
2014 journal article
Episcleral, intrascleral, and suprachoroidal routes of ocular drug delivery – Recent research advances and patents
Recent Patents on Drug Delivery and Formulation.
Sources: NC State University Libraries, NC State University Libraries
Added: December 16, 2019
2014 review
Equine orbital fractures: a review of 18 cases (2006-2013)
[Review of ]. VETERINARY OPHTHALMOLOGY, 17, 97–106.
author keywords: Complication; equine; fracture; orbital; outcome; retrospective
MeSH headings : Animals; Female; Horses / injuries; Male; Orbital Fractures / complications; Orbital Fractures / diagnostic imaging; Orbital Fractures / etiology; Orbital Fractures / therapy; Orbital Fractures / veterinary; Retrospective Studies; Tomography, X-Ray Computed / veterinary; Zygomatic Fractures / complications; Zygomatic Fractures / diagnostic imaging; Zygomatic Fractures / etiology; Zygomatic Fractures / therapy; Zygomatic Fractures / veterinary
TL;DR:
Horses sustaining orbital fractures treated promptly with medical and surgical therapy have a favorable prognosis for return to function and cosmesis and warrant more aggressive therapy and decrease functional and cosmetic outcome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Modified lamellar keratoplasties for the treatment of deep stromal abscesses in horses
Veterinary Ophthalmology, 18(5), 393–403.
author keywords: deep lamellar endothelial keratoplasty; deep stromal abscess; equine ophthalmology; posterior lamellar keratoplasty; sedation; standing surgery
MeSH headings : Abscess / surgery; Abscess / veterinary; Animals; Corneal Diseases / surgery; Corneal Diseases / veterinary; Corneal Stroma / surgery; Corneal Transplantation / methods; Corneal Transplantation / veterinary; Female; Horse Diseases / surgery; Horses / surgery; Male
TL;DR:
In horses with deep stromal or endothelial abscesses, for which general anesthesia is not an option, both the modified DLEK and PLK corneal procedures may be performed as an alternative to enucleation on the standing, sedated horse.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2014 journal article
Retrospective analysis of equine cataract surgery – visual outcomes vs age, IOL, and ERU status (35 cases)
Veterinary Ophthalmology, 17, 160–167.
author keywords: cataracts; chronic uveitis; equine; intraocular lens; phacoemulsification; prognosis
MeSH headings : Age Factors; Animals; Cataract / veterinary; Female; Horses; Lenses, Intraocular / veterinary; Male; Phacoemulsification / adverse effects; Phacoemulsification / veterinary; Postoperative Complications / veterinary; Retrospective Studies; Treatment Outcome; Uveitis / etiology; Uveitis / veterinary; Vision Disorders / etiology; Vision Disorders / veterinary
TL;DR:
Horses with chronic uveitis had significantly less favorable visual outcome after PA, and older age at surgery and IOL use were not associated with poor visual outcome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Spectral-domain optical coherence tomography evaluation of the cornea, retina, and optic nerve in normal horses
Veterinary Ophthalmology, 17, 140–148.
author keywords: SD-OCT; equine; cornea; retina; pachymetry
MeSH headings : Animals; Cornea / anatomy & histology; Feasibility Studies; Female; Horses / anatomy & histology; Male; Optic Nerve / anatomy & histology; Retina / anatomy & histology; Tomography, Optical Coherence / veterinary
TL;DR:
The SD-OCT instrument employed in this study may be used on sedated horses and allows the acquisition of high-resolution images, and thickness measurements involving the cornea, retina, and optic nerve.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2014 journal article
Surgical correction of lens luxation in the horse: visual outcomes
Veterinary Medicine and Animal Sciences, 2(1), 2.
TL;DR:
The visual outcomes of surgical therapy for lens luxation/subluxation in the horse were described and the medical records of horses that had undergone surgery were obtained.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019
2014 journal article
Use of episcleral cyclosporine implants in dogs with keratoconjunctivitis sicca
Veterinary Ophthalmology, 18(3), 234–241.
author keywords: cyclosporine; dog; dry eye; implant; keratoconjunctivitis sicca; sustained release delivery
MeSH headings : Animals; Conjunctiva / drug effects; Cyclosporine / administration & dosage; Cyclosporine / therapeutic use; Dog Diseases / drug therapy; Dogs; Female; Immunosuppressive Agents / administration & dosage; Keratoconjunctivitis Sicca / drug therapy; Keratoconjunctivitis Sicca / veterinary; Male; Prostheses and Implants / veterinary; Retrospective Studies
TL;DR:
Results from this study suggest that the EMSC implants were well tolerated and efficacious in dogs with KCS responsive to topical CsA as well as dogs with poor response to topical therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2014 article
Veterinary Ophthalmology - Equine Ophthalmology Special Issue Preface
Clode, A., & Gilger, B. (2014, July). VETERINARY OPHTHALMOLOGY, Vol. 17, pp. 1–1.
MeSH headings : Animals; Eye Diseases / diagnosis; Eye Diseases / therapy; Eye Diseases / veterinary; Horse Diseases / diagnosis; Horse Diseases / therapy; Horses
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 chapter
Challenges in Ocular Pharmacokinetics, Pharmacodynamics, and Toxicology
In Methods in Pharmacology and Toxicology (pp. 1–6).
Sources: Crossref, NC State University Libraries
Added: November 16, 2019
2013 journal article
Effect of Choroidal Perfusion on Ocular Tissue Distribution After Intravitreal or Suprachoroidal Injection in an Arterially Perfused Ex Vivo Pig Eye Model
Journal of Ocular Pharmacology and Therapeutics, 29(8), 715–722.
MeSH headings : Animals; Carbocyanines / pharmacokinetics; Choroid / blood supply; Choroid / drug effects; Choroid / metabolism; Ciliary Arteries; Drug Delivery Systems; Female; Fluorescein / pharmacokinetics; In Vitro Techniques; Intravitreal Injections; Male; Metabolic Clearance Rate; Microcirculation; Microscopy, Fluorescence; Perfusion; Regional Blood Flow; Swine; Tissue Distribution; Vitreous Body / blood supply; Vitreous Body / drug effects; Vitreous Body / metabolism
TL;DR:
Choroidal circulation reduces the tissue drug concentration of the hydrophilic drug suggesting an early clearance mechanism after SCS delivery, which is higher in nonperfused eyes compared to perfused eyes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2013 journal article
Histopathologic features of equine superficial, nonhealing, corneal ulcers
Veterinary Ophthalmology, 17(s1), 46–52.
author keywords: corneal; equine; indolent; nonhealing; superficial; ulcer
MeSH headings : Animals; Cornea / pathology; Corneal Stroma / pathology; Corneal Ulcer / pathology; Corneal Ulcer / veterinary; Epithelium, Corneal / pathology; Female; Horse Diseases / pathology; Horses; Male; Retrospective Studies
TL;DR:
The most consistent histopathological characteristics of equine chronic, nonhealing, superficial, corneal ulcers include epithelial nonadherence, epithelial dysmaturity and mild to moderate stromal inflammation; however, one set of histopathology characteristics does not definitively define this syndrome in horses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2013 journal article
Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice
TOXICOLOGY AND APPLIED PHARMACOLOGY, 272(2), 503–518.
author keywords: Aryl hydrocarbon receptor knockout rat; Aryl hydrocarbon receptor knockout mouse; Comparison; Tissue phenotypes; Liver; Kidney
MeSH headings : Animals; Gene Deletion; Gene Knockdown Techniques; Kidney / drug effects; Kidney / metabolism; Kidney / pathology; Liver / drug effects; Liver / metabolism; Liver / pathology; Mice; Mice, Knockout; Organ Size / genetics; Phenotype; Polychlorinated Dibenzodioxins / toxicity; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon / genetics; Receptors, Aryl Hydrocarbon / metabolism; Species Specificity
TL;DR:
The present data indicate that the AHR may play significantly different roles in tissue development and homeostasis and toxicity across rodent species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 chapter
Selection of Appropriate Animal Models in Ocular Research: Ocular Anatomy and Physiology of Common Animal Models
In Methods in Pharmacology and Toxicology (pp. 7–32).
Sources: Crossref, NC State University Libraries
Added: November 16, 2019
2013 journal article
The effect of 1% tropicamide-induced mydriasis and cycloplegia on spherical refraction of the adult horse
Veterinary Ophthalmology, 17(2), 120–125.
author keywords: cycloplegia; equine ophthalmology; mydriasis; pupillometry; streak retinoscopy; tropicamide
MeSH headings : Animals; Eye / drug effects; Female; Horses; Muscarinic Antagonists / administration & dosage; Muscarinic Antagonists / pharmacology; Mydriasis / chemically induced; Mydriasis / veterinary; Tropicamide / administration & dosage; Tropicamide / pharmacology
TL;DR:
Optimal streak retinoscopy results may be obtained prior to, or 40- to 45-min following the application of topical tropicamide 1%, once near-maximal dilation has been achieved.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2013 journal article
Treatment of Acute Posterior Uveitis in a Porcine Model by Injection of Triamcinolone Acetonide Into the Suprachoroidal Space Using Microneedles
Investigative Opthalmology & Visual Science, 54(4), 2483.
author keywords: drug delivery; suprachoroidal space; microneedle; posterior segment; uveitis
MeSH headings : Acute Disease; Animals; Aqueous Humor / cytology; Aqueous Humor / metabolism; Cell Count; Choroid; Disease Models, Animal; Electroretinography / drug effects; Extracellular Space; Eye Proteins / metabolism; Female; Glucocorticoids / therapeutic use; Intraocular Pressure / drug effects; Intravitreal Injections; Leukocytes / pathology; Male; Needles; Sus scrofa; Tomography, Optical Coherence; Triamcinolone Acetonide / therapeutic use; Uveitis, Posterior / drug therapy; Uveitis, Posterior / pathology; Vitreous Body / metabolism; Vitreous Body / pathology
TL;DR:
Delivery of TA to the SCS using microneedles was simple, effective, and not associated with adverse effects or toxicity, and there were no adverse effects, increased IOP, or evidence of procedural or drug toxicity following injection of TA into theSCS in porcine eyes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2013 journal article
Treatment of immune-mediated keratitis in horses with episcleral silicone matrix cyclosporine delivery devices
Veterinary Ophthalmology, 17, 23–30.
author keywords: cyclosporine; horse; immune-mediated; keratitis; sustained release
MeSH headings : Animals; Cyclosporine / administration & dosage; Cyclosporine / therapeutic use; Drug Implants / administration & dosage; Female; Horse Diseases / drug therapy; Horses; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / therapeutic use; Keratitis / drug therapy; Keratitis / veterinary; Male; Sclera; Silicones; Treatment Outcome
TL;DR:
Results from this preliminary retrospective study suggest that the ESMC implants were well tolerated and associated with treatment success with superficial and endothelial IMMK, especially if placed early in the disease process.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2013 book
Source: NC State University Libraries
Added: July 27, 2021
2012 journal article
A topical aqueous calcineurin inhibitor for the treatment of naturally occurring keratoconjunctivitis sicca in dogs
Veterinary Ophthalmology, 16(3), 192–197.
author keywords: calcineurin inhibitor; canine; clinical trial; keratoconjunctivitis sicca
MeSH headings : Administration, Topical; Animals; Calcineurin Inhibitors; Cyclosporins / pharmacology; Dog Diseases / drug therapy; Dogs; Double-Blind Method; Keratoconjunctivitis Sicca / drug therapy; Keratoconjunctivitis Sicca / veterinary; Pilot Projects
TL;DR:
Results indicate that topical SCY-641, in a stable clear aqueous solution, is efficacious in a spontaneous model of KCS and warrants further evaluation as a treatment of immune-mediated KCS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
Diode laser endoscopic cyclophotocoagulation in the normal equine eye
VETERINARY OPHTHALMOLOGY, 16(2), 97–110.
author keywords: diode laser; endoscopic cyclophotocoagulation; equine; glaucoma; histopathology
MeSH headings : Animals; Cadaver; Endoscopes / veterinary; Eye; Horses; Lasers, Semiconductor; Light Coagulation / instrumentation; Light Coagulation / methods; Light Coagulation / veterinary; Ophthalmologic Surgical Procedures / methods; Ophthalmologic Surgical Procedures / veterinary
TL;DR:
Diode ECP between 0.90 and 1.14 J is a potential treatment option for glaucoma in horses based on visible tissue effects and target ciliary epithelium damage and may limit the use of an anterior chamber approach in phakic horses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Evaluation of diode endoscopic cyclophotocoagulation in bovine cadaver eyes
AMERICAN JOURNAL OF VETERINARY RESEARCH, 73(9), 1445–1452.
MeSH headings : Animals; Cadaver; Cattle; Cattle Diseases / pathology; Cattle Diseases / surgery; Endoscopy / methods; Endoscopy / veterinary; Glaucoma / pathology; Glaucoma / surgery; Glaucoma / veterinary; Histocytochemistry; Laser Coagulation / instrumentation; Laser Coagulation / methods; Laser Coagulation / veterinary
TL;DR:
Evaluating the anterior chamber approach and energy levels for endoscopic cyclophotocoagulation (ECPC) and assessing ECPC-induced tissue damage in phakic eyes of bovine cadavers found the 0.75- and 0.90-J energy levels had the potential to effectively treat the ciliary epithelium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Extraocular lymphoma in the horse
Veterinary Ophthalmology, 16(1), 35–42.
author keywords: conjunctiva; conjunctivitis; equine; extraocular; eyelid; lymphoma
MeSH headings : Animals; Conjunctival Neoplasms / diagnosis; Conjunctival Neoplasms / pathology; Conjunctival Neoplasms / veterinary; Corneal Diseases / diagnosis; Corneal Diseases / pathology; Corneal Diseases / veterinary; Eye Neoplasms / diagnosis; Eye Neoplasms / pathology; Eye Neoplasms / veterinary; Eyelid Neoplasms / diagnosis; Eyelid Neoplasms / pathology; Eyelid Neoplasms / veterinary; Female; Horse Diseases / diagnosis; Horse Diseases / pathology; Horses; Lymphoma / diagnosis; Lymphoma / pathology; Lymphoma / veterinary; Male; Prognosis; Retrospective Studies
TL;DR:
The prognosis for clinical remission in horses with extraocular lymphoma is generally fair to good, as long as the affected tissues are completely excised, and there is no eyelid or cutaneous involvement.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
Immunohistochemical and immunopathologic characterization of superficial stromal immune-mediated keratitis in horses
American Journal of Veterinary Research, 73(7), 1067–1073.
TL;DR:
Pathogenesis of superficial stromal immune-mediated keratitis included cell-mediated inflammation governed by both cytotoxic and helper T cells and local immunoglobulins were present in affected corneas; however, corneal-binding immunoglolins were not detected in the serum or AH from horses with IMMK.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 chapter
Ophthalmic disorders
In D. A. Wilson (Ed.), Clinical Veterinary Advisor, The Horse. St. Louis, MO: Elsevier Saunders.
Ed(s): D. Wilson
Source: NC State University Libraries
Added: October 20, 2020
2012 journal article
Phacoemulsification and +14 diopter intraocular lens placement in a Saddlebred foal
VETERINARY OPHTHALMOLOGY, 16(2), 140–148.
author keywords: cataract; equine phacoemulsification; foal; intraocular lens; ocular ultrasound; retinoscopy
MeSH headings : Animals; Cataract / pathology; Cataract / therapy; Cataract / veterinary; Cataract Extraction / methods; Cataract Extraction / veterinary; Female; Horse Diseases / surgery; Horse Diseases / therapy; Horses; Lens Implantation, Intraocular / veterinary; Phacoemulsification / veterinary
TL;DR:
A +14 diopter (D) intraocular lens (IOL) IOL may be the appropriate choice following lens extraction in a foal to achieve refraction near emmetropia at maturity at maturity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Sustained-Release Celecoxib from Incubated Acrylic Intraocular Lenses Suppresses Lens Epithelial Cell Growth in an Ex Vivo Model of Posterior Capsule Opacity
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, 28(4), 359–368.
MeSH headings : Animals; Cataract Extraction; Celecoxib; Corneal Opacity / pathology; Corneal Opacity / prevention & control; Cyclooxygenase 2 Inhibitors / administration & dosage; Cyclooxygenase 2 Inhibitors / pharmacokinetics; Cyclooxygenase 2 Inhibitors / therapeutic use; Delayed-Action Preparations; Dogs; Epithelial Cells / drug effects; Epithelium / drug effects; Epithelium / growth & development; In Vitro Techniques; Lens, Crystalline / cytology; Lens, Crystalline / drug effects; Lens, Crystalline / growth & development; Lenses, Intraocular; Polymethyl Methacrylate; Posterior Capsule of the Lens / cytology; Posterior Capsule of the Lens / drug effects; Posterior Capsule of the Lens / pathology; Postoperative Complications / pathology; Postoperative Complications / prevention & control; Pyrazoles / administration & dosage; Pyrazoles / pharmacokinetics; Pyrazoles / therapeutic use; Sulfonamides / administration & dosage; Sulfonamides / pharmacokinetics; Sulfonamides / therapeutic use
TL;DR:
A 4-day treatment of LCs with a concentration of 20 μM CXB may effectively prevent PCO and further studies are needed to determine whether C XB-incubated IOLs can effectively prevent the development of PCO in vivo.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 article
The search for causes of nonhealing or recurrent ulcerative keratitis in horses
Gilger, B. C. (2012, November). EQUINE VETERINARY EDUCATION, Vol. 24, pp. 561–562.
author keywords: horse; cornea; ulcer; chronic; recurrent; distichiasis
TL;DR:
Common causes of chronic or recurrent superficial ulcerative keratitis, such as infectious keratritis, should always be ruled out; however, other possible causes such as single or multiple distichiasis, should be considered.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
A retrospective comparison of surgical removal and subsequent CO2 laser ablation versus topical administration of mitomycin C as therapy for equine corneolimbal squamous cell carcinoma
VETERINARY OPHTHALMOLOGY, 15(4), 254–262.
author keywords: cornea; equine; mitomycin; squamous cell carcinoma
MeSH headings : Administration, Topical; Animals; Antibiotics, Antineoplastic / administration & dosage; Antibiotics, Antineoplastic / therapeutic use; Carcinoma, Squamous Cell / drug therapy; Carcinoma, Squamous Cell / surgery; Carcinoma, Squamous Cell / veterinary; Eye Neoplasms / drug therapy; Eye Neoplasms / surgery; Eye Neoplasms / veterinary; Female; Horse Diseases / drug therapy; Horse Diseases / surgery; Horse Diseases / therapy; Horses; Lasers, Gas / therapeutic use; Male; Mitomycin / administration & dosage; Mitomycin / therapeutic use; Ophthalmologic Surgical Procedures / methods; Ophthalmologic Surgical Procedures / veterinary; Retrospective Studies
TL;DR:
Horses receiving adjunctive topical MMC therapy were no more likely to experience tumor recurrence than were horses undergoing CO(2) laser ablation in the horses in this study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Aqueous humor and plasma concentrations of a compounded 0.2% solution of terbinafine following topical ocular administration to normal equine eyes
Veterinary Ophthalmology, 14(1), 41–47.
author keywords: aqueous humor; equine; keratomycosis; terbinafine
MeSH headings : Absorption; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / analysis; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Aqueous Humor / chemistry; Chromatography, High Pressure Liquid / veterinary; Cornea / metabolism; Female; Horses / metabolism; Male; Naphthalenes / administration & dosage; Naphthalenes / analysis; Naphthalenes / blood; Naphthalenes / pharmacokinetics; Ophthalmic Solutions; Terbinafine
TL;DR:
Topical ocular administration of compounded 0.2% terbinafine solution does not result in detectable AH or plasma levels following administration to normal equine eyes, suggesting its use for deep corneal or intraocular fungal infections in equine ophthalmology may be limited.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2011 journal article
Carbon dioxide laser photoablation adjunctive therapy following superficial lamellar keratectomy and bulbar conjunctivectomy for the treatment of corneolimbal squamous cell carcinoma in horses: a review of 24 cases
VETERINARY OPHTHALMOLOGY, 15(4), 245–253.
author keywords: carbon dioxide laser; cornea; equine; limbus; ophthalmology; squamous cell carcinoma
MeSH headings : Animals; Carcinoma, Squamous Cell / surgery; Carcinoma, Squamous Cell / veterinary; Corneal Surgery, Laser / veterinary; Eye Neoplasms / surgery; Eye Neoplasms / veterinary; Female; Horse Diseases / surgery; Horses; Lasers, Gas / therapeutic use; Male; Ophthalmologic Surgical Procedures / methods; Ophthalmologic Surgical Procedures / veterinary; Retrospective Studies
TL;DR:
CO(2) photoablation appears to be effective as an adjunctive therapy following removal of large corneolimbal SCC in the horse and in cases in which all tumor cells were not excised.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Challenges in the treatment of equine periocular squamous cell carcinoma
EQUINE VETERINARY EDUCATION, 23(10), 500–501.
author keywords: horse; ocular; squamous cell carcinoma; metastasis; treatment
TL;DR:
Management of periocular squamous cell carcinoma is challenging because of the need for adjunctive therapy, the adverse effects of therapies and the frequent recurrence of SCC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Concerns with analysis of correlated eye data
Veterinary Ophthalmology, 14(3), 214–214.
MeSH headings : Animals; Clinical Trials as Topic / methods; Clinical Trials as Topic / veterinary; Data Interpretation, Statistical; Dry Eye Syndromes / drug therapy; Dry Eye Syndromes / veterinary; Rabbits; Statistics as Topic / methods
TL;DR:
There continues to be studies published that do not take into account data that is highly correlated, such as the right (OD) and left eyes (OS) in a single animal, and it is recommended that a statistician be consulted to appropriately analyze this data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Diagnosis of intraocular lymphosarcoma in a dog by use of a polymerase chain reaction assay for antigen receptor rearrangement
Journal of the American Veterinary Medical Association, 238(5), 625–630.
MeSH headings : Animals; Antineoplastic Agents / therapeutic use; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Eye Neoplasms / diagnosis; Eye Neoplasms / drug therapy; Eye Neoplasms / pathology; Eye Neoplasms / veterinary; Lymphoma, Non-Hodgkin / diagnosis; Lymphoma, Non-Hodgkin / drug therapy; Lymphoma, Non-Hodgkin / veterinary; Male; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; Receptors, Antigen
TL;DR:
In the dog of this report, intraocular lymphosarcoma was diagnosed via PARR performed on samples of aqueous humor and the immunophenotype of the neoplastic cells was determined by use of that diagnostic technique.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2011 journal article
Effect and Distribution of Contrast Medium after Injection into the Anterior Suprachoroidal Space in Ex Vivo Eyes
Investigative Opthalmology & Visual Science, 52(8), 5730.
MeSH headings : Age Factors; Animals; Anterior Chamber / diagnostic imaging; Anterior Chamber / metabolism; Choroid / diagnostic imaging; Choroid / metabolism; Contrast Media / pharmacokinetics; Dogs; Drug Delivery Systems; Imaging, Three-Dimensional; In Vitro Techniques; Injections, Intraocular / methods; Latex / pharmacokinetics; Microbubbles; Posterior Eye Segment / diagnostic imaging; Posterior Eye Segment / metabolism; Retina / diagnostic imaging; Retina / metabolism; Swine; Ultrasonography
TL;DR:
The authors' hypothesis that a single anterior SCS injection can reach the ocular posterior segment was supported and it is suggested that the SCS can expand, in a dose-dependent manner, to accommodate various volumes of fluid and that it is possible to image theSCS with ultrasound contrast.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2011 article
Equine Ocular Examination
Equine Ophthalmology, pp. 1–51.
Source: ORCID
Added: September 9, 2019
2011 book
Source: NC State University Libraries
Added: October 20, 2020
2011 article
Equine Recurrent Uveitis
Equine Ophthalmology, pp. 317–349.
Source: ORCID
Added: September 9, 2019
2011 journal article
Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration
British Journal of Ophthalmology, 95(12), 1749–1754.
MeSH headings : Animals; Animals, Genetically Modified; Disease Models, Animal; Electroretinography; Eye Proteins / biosynthesis; Eye Proteins / genetics; Gene Deletion; Immunohistochemistry; Macular Degeneration / metabolism; Macular Degeneration / pathology; Macular Degeneration / physiopathology; Membrane Proteins / biosynthesis; Membrane Proteins / genetics; Microscopy, Fluorescence; Mutation; Retina / metabolism; Retina / pathology; Retina / physiopathology; Swine
TL;DR:
These transgenic pigs provide unique animal models for examining macular degeneration and STGD3 pathogenesis and direct fluorescence microscopy indicated that the Y270terEYFP protein is expressed in photoreceptors and mislocalised within the cell.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018
2011 chapter
Suprachoroidal and intrascleral drug delivery
In U. Kompella & H. Edelhauser (Eds.), Drug Product Development for the Back of the Eye. New York: Springer Publications.
Ed(s): U. Kompella & H. Edelhauser
Source: NC State University Libraries
Added: October 20, 2020
2010 journal article
Advancements in ocular drug delivery
Veterinary Ophthalmology, 13(6), 395–406.
author keywords: drug delivery; eye; implants; therapeutics; veterinary
MeSH headings : Administration, Topical; Animals; Delayed-Action Preparations; Drug Delivery Systems / veterinary; Eye Diseases / drug therapy; Eye Diseases / veterinary; Prostheses and Implants / veterinary
TL;DR:
In addition to addressing the physiologic challenges of achieving the necessary duration of delivery, tissue targeting and patient compliance, the commercial development factors of biocompatibility, sterilization, manufacturability and long-term stability will be discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Aqueous humor and plasma concentrations of ciprofloxacin and moxifloxacin following topical ocular administration in ophthalmologically normal horses
American Journal of Veterinary Research, 71(5), 564–569.
MeSH headings : Administration, Oral; Administration, Topical; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / metabolism; Aqueous Humor / metabolism; Aza Compounds / administration & dosage; Aza Compounds / blood; Aza Compounds / metabolism; Ciprofloxacin / administration & dosage; Ciprofloxacin / blood; Ciprofloxacin / metabolism; Female; Fluoroquinolones; Horses / blood; Horses / metabolism; Male; Moxifloxacin; Orchiectomy / veterinary; Quinolines / administration & dosage; Quinolines / blood; Quinolines / metabolism
TL;DR:
Moxifloxacin was better able to penetrate healthy equine corneas and reach measurable AH concentrations than was ciprofloxacIn, suggesting moxif loxac in might be of greater value in the treatment of deep corneal or intraocular bacterial infections caused by susceptible organisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2010 journal article
CASE REPORT: Anomalous nasolacrimal openings in a 2-year-old Morgan filly
Veterinary Ophthalmology, 13(5), 339–342.
author keywords: computed tomography; congenital; epiphora; equine; nasolacrimal duct
MeSH headings : Animals; Female; Horse Diseases / pathology; Horse Diseases / surgery; Horses / abnormalities; Nasolacrimal Duct / abnormalities; Nasolacrimal Duct / surgery
TL;DR:
This case report describes the clinical, diagnostic, computed tomography findings, and surgical treatment of a 2-year-old Morgan filly with bilateral, proximal, and distal anomalous nasolacrimal duct openings.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2010 journal article
Effect of three treatment protocols on acute ocular hypertension after phacoemulsification and aspiration of cataracts in dogs
Veterinary Ophthalmology, 13(1), 14–19.
author keywords: carbachol; cataract; dogs; IOP; latanoprost; phacoemulsification
MeSH headings : Administration, Topical; Animals; Carbachol / therapeutic use; Cataract Extraction / adverse effects; Cataract Extraction / veterinary; Dog Diseases / drug therapy; Dog Diseases / prevention & control; Dog Diseases / surgery; Dogs; Intraocular Pressure / drug effects; Latanoprost; Ocular Hypertension / etiology; Ocular Hypertension / prevention & control; Ocular Hypertension / veterinary; Phacoemulsification / adverse effects; Phacoemulsification / veterinary; Postoperative Period; Prostaglandins F, Synthetic / therapeutic use; Retrospective Studies
TL;DR:
Topical 0.005% latanoprost or intracameral injection after PA in dogs did not reduce POH or increase intraocular inflammation compared to dogs not receiving adjunctive therapy after PA of cataracts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2010 journal article
Equine immune-mediated keratopathies
Equine Veterinary Journal, 42(S37), 31–37.
MeSH headings : Animals; Anti-Inflammatory Agents / therapeutic use; Corneal Diseases / drug therapy; Corneal Diseases / epidemiology; Corneal Diseases / immunology; Corneal Diseases / pathology; Corneal Diseases / veterinary; Horse Diseases / drug therapy; Horse Diseases / epidemiology; Horse Diseases / immunology; Horse Diseases / pathology; Horses; Immunosuppressive Agents / therapeutic use; United Kingdom / epidemiology; United States / epidemiology
TL;DR:
The currently recognised clinical presentations of the IMMKs in the USA and in the UK are described and recurrence or refractoriness to treatment is possible.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: September 9, 2019
2010 journal article
Equine recurrent uveitis: The viewpoint from the USA
Equine Veterinary Journal, 42(S37), 57–61.
MeSH headings : Animals; Anti-Inflammatory Agents / therapeutic use; Horse Diseases / epidemiology; Horse Diseases / pathology; Horse Diseases / therapy; Horses; Leptospirosis / complications; Leptospirosis / veterinary; Recurrence; United States / epidemiology; Uveitis / epidemiology; Uveitis / pathology; Uveitis / therapy; Uveitis / veterinary
TL;DR:
Standard symptomatic anti-inflammatory therapy is effective to control most cases of ERU; however, some horses require advanced therapy, such as placement of drug delivery devices or removal of the vitreous, when they fail to respond to the standard therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: July 21, 2019
2010 journal article
Evaluation of 30- and 25-diopter intraocular lens implants in equine eyes after surgical extraction of the lens
American Journal of Veterinary Research, 71(7), 809–816.
MeSH headings : Animals; Anterior Chamber / surgery; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / therapeutic use; Euthanasia, Animal; Eye Enucleation / methods; Eye Enucleation / veterinary; Horse Diseases / surgery; Horses; Lens Implantation, Intraocular / methods; Lens Implantation, Intraocular / veterinary; Lens, Crystalline / anatomy & histology; Lens, Crystalline / surgery; Lenses, Intraocular / veterinary; Refraction, Ocular / physiology; Refractive Errors / therapy; Refractive Errors / veterinary; Refractive Surgical Procedures / methods; Refractive Surgical Procedures / veterinary
TL;DR:
Investigation of intraocular lens (IOL) implant strength to approximate emmetropia in horses found insertion of 30-D (enucleated globes) and 25-D IOL implants (adult horses) resulted in overcorrection of refractive error.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2010 journal article
Long-term outcome after implantation of a suprachoroidal cyclosporine drug delivery device in horses with recurrent uveitis
Veterinary Ophthalmology, 13(5), 294–300.
author keywords: cyclosporine; equine; implant; recurrent uveitis
MeSH headings : Animals; Cyclosporine / administration & dosage; Cyclosporine / therapeutic use; Female; Horse Diseases / drug therapy; Horses; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / therapeutic use; Infusion Pumps, Implantable / veterinary; Male; Uveitis / drug therapy; Uveitis / veterinary
TL;DR:
The increased vision loss related to uveitis episode of inflammation in eyes after the likely depletion of CsA from the CSI suggests that a repeat CSI may be required at or before 48 months after surgery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2010 journal article
Ophthalmic Drug Delivery Systems for the Treatment of Retinal Diseases: Basic Research to Clinical Applications
Investigative Opthalmology & Visual Science, 51(11), 5403.
MeSH headings : Biomedical Research; Drug Delivery Systems; Humans; Ophthalmic Solutions / administration & dosage; Pharmaceutical Preparations / administration & dosage; Retinal Diseases / drug therapy
TL;DR:
The basic science part of this article focuses on the anatomic barriers to the five major modes of ocular drug delivery: intraocular, periocular, hybrid, topical, and systemic.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019
2010 journal article
Topical delivery of hydrophobic drugs using a novel mixed nanomicellar technology to treat diseases of the anterior and posterior segments of the eye
Drug Delivery Technology, 10(4), 42–47.
Source: NC State University Libraries
Added: October 20, 2020
2009 journal article
Comparison of capsular opacification and refractive status after placement of three different intraocular lens implants following phacoemulsification and aspiration of cataracts in dogs
Veterinary Ophthalmology, 12(1), 13–21.
author keywords: design; dog; intraocular lens; material; posterior capsular opacification; refractive error
MeSH headings : Acrylic Resins; Animals; Cataract / veterinary; Cataract Extraction / instrumentation; Cataract Extraction / methods; Cataract Extraction / veterinary; Dog Diseases / surgery; Dogs; Female; Lens Implantation, Intraocular / instrumentation; Lens Implantation, Intraocular / methods; Lens Implantation, Intraocular / veterinary; Male; Phacoemulsification / veterinary; Polymethyl Methacrylate; Prosthesis Design; Random Allocation; Treatment Outcome
TL;DR:
Square edged foldable acrylic IOLs show a predisposition towards generating slightly less PCO than round edged PMMA I OLs in the early postoperative period, however, both acrylic Iols had greater persistent hyperopia than the PMMAIOLs.
(via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2009 chapter
Enucleation
In N. E. Robinson & K. A. Sprayberry (Eds.), Current Therapy in Equine Medicine (6th ed.). St. Louis, MO: Saunders Elsevier.
Ed(s): N. Robinson & K. Sprayberry
Source: NC State University Libraries
Added: October 20, 2020
2009 chapter
Equine Recurrent Uveitis
In N. E. Robinson & K. A. Sprayberry (Eds.), Current Therapy in Equine Medicine (6th ed.). St. Louis, Missouri: Elsevier Saunders.
Ed(s): N. Robinson & K. Sprayberry
Source: NC State University Libraries
Added: February 2, 2024
2009 journal article
Equine immune-mediated keratopathies
Veterinary Ophthalmology, 12, 10–16.
author keywords: cornea; equine; immune-mediated; keratitis; nonulcerative
MeSH headings : Animals; Horse Diseases / immunology; Horse Diseases / pathology; Horses; Keratitis / immunology; Keratitis / pathology; Keratitis / veterinary
TL;DR:
The clinical differences in horses with this disease are compared and the current theories on pathogenesis and treatment of equine IMMK are reviewed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Infrared digital imaging of the equine anterior segment
Veterinary Ophthalmology, 12(2), 125–131.
author keywords: anterior segment; corneal disease; digital infrared photography; equine; melanoma; equine ophthalmology
MeSH headings : Animals; Eye / anatomy & histology; Eye Diseases / diagnosis; Eye Diseases / veterinary; Horse Diseases / diagnosis; Horses / anatomy & histology; Infrared Rays; Ophthalmology / instrumentation; Ophthalmology / methods; Photography / instrumentation; Photography / methods; Photography / veterinary
TL;DR:
In the equine eye, advantages of infrared digital photography include increased contrast of anterior segment images, identification and monitoring of pigmentary changes, and increased visualization of the anterior segment through a cloudy or edematous cornea.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2009 article
International Equine Ophthalmology Consortium (IEOC) Symposium
Gilger, B. C., & Brooks, D. E. (2009, July). EQUINE VETERINARY JOURNAL, Vol. 41, pp. 606–607.
author keywords: horse; ophthalmology; workshop; Havemeyer; International Equine Ophthalmology Consortium
MeSH headings : Animals; Eye Diseases / diagnosis; Eye Diseases / therapy; Eye Diseases / veterinary; Horse Diseases / diagnosis; Horse Diseases / therapy; Horses; Ophthalmologic Surgical Procedures / veterinary
TL;DR:
Development of an IEOC membership organisation and website was discussed and supported by the group in an effort further to advance the science of equine ophthalmology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Quantitative differences in mRNA expression of Toll-like receptor (TLR)-2, -4, and -9 in normal equine eyes and eyes with equine recurrent uveitis.
Journal of Veterinary Clinics, 26(6), 520–523.
Source: NC State University Libraries
Added: December 22, 2020
2009 journal article
Surgical correction of severe strabismus and enophthalmos secondary to zygomatic arch fracture in a dog
Veterinary Ophthalmology, 12(2), 119–124.
author keywords: dog; fracture; miniplate fixation; orbital rim
MeSH headings : Animals; Bone Plates / veterinary; Dog Diseases / surgery; Dogs; Enophthalmos / surgery; Enophthalmos / veterinary; Male; Strabismus / surgery; Strabismus / veterinary; Zygomatic Fractures / surgery; Zygomatic Fractures / veterinary
TL;DR:
A grossly displaced segmental zygomatic arch fracture with marked ventro-lateral deviation of the left globe was diagnosed in a 3-month-old male German Shepherd dog following a bite injury and surgical correction achieved sufficient skeletal fixation for proper anatomical reduction of the globe.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2008 journal article
A moment of SCIENCE . . . Please!
Veterinary Ophthalmology, 11(5), 279–279.
MeSH headings : Animals; Evidence-Based Medicine; Ophthalmology / education; Veterinary Medicine / standards
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Epibulbar melanoma in a foal
Veterinary Ophthalmology, 11, 44–50.
author keywords: congenital; epibulbar; equine; melanoma; neoplasia
MeSH headings : Animals; Animals, Newborn; Choroid Neoplasms / pathology; Choroid Neoplasms / surgery; Choroid Neoplasms / veterinary; Eye Enucleation / methods; Eye Enucleation / veterinary; Eye Neoplasms / pathology; Eye Neoplasms / surgery; Eye Neoplasms / veterinary; Horse Diseases / pathology; Horse Diseases / surgery; Horses; Limbus Corneae; Macrophages / pathology; Male; Melanoma / pathology; Melanoma / surgery; Melanoma / veterinary; Pigment Epithelium of Eye / pathology; Treatment Outcome
TL;DR:
Based on the sudden onset and rapid growth as well as the histological evidence of invasion, well-differentiated features, heavy pigmentation, and no apparent mitoses, this neoplasm was considered to be a low-grade malignant melanoma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2008 journal article
Equine special edition of veterinary ophthalmology
Veterinary Ophthalmology, 11, 1–1.
MeSH headings : Animals; Eye Diseases / diagnosis; Eye Diseases / therapy; Eye Diseases / veterinary; Horse Diseases / diagnosis; Horse Diseases / therapy; Horses; Ophthalmology / methods; Veterinary Medicine / methods
TL;DR:
This equine special edition of Veterinary Ophthalmology demonstrates that the field of equine ophthalmology is meeting the challenge, however, much more work is needed regarding characterization of specific equine diseases and the development of effective, safe, and practical treatments.
(via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Immunology of the Ocular Surface
Veterinary Clinics of North America: Small Animal Practice, 38(2), 223–231.
MeSH headings : Adaptation, Physiological; Animals; Autoantigens / immunology; Eye Infections / immunology; Eye Infections / veterinary; Immunity, Innate; Receptors, Cell Surface / immunology; Receptors, Cell Surface / metabolism; Receptors, Immunologic / immunology; Receptors, Immunologic / metabolism; Toll-Like Receptors / immunology; Toll-Like Receptors / metabolism
TL;DR:
Toll-like receptors are the link between the innate and adaptive immune response, and are likely key components of the response of ocular tissue to infectious organisms and in the initiation and perpetuation of autoimmune disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2008 journal article
Letter to the Editor
Veterinary Ophthalmology, 11(3), 207–207.
MeSH headings : Animals; Controlled Clinical Trials as Topic; Diagnostic Techniques, Ophthalmological / standards; Dog Diseases / diagnosis; Dogs; Evidence-Based Medicine; Glaucoma / diagnosis; Glaucoma / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Multifocal Electroretinogram in Rhodopsin P347L Transgenic Pigs
Investigative Opthalmology & Visual Science, 49(5), 2208.
MeSH headings : Aminobutyrates; Animals; Animals, Genetically Modified; Computers, Handheld; Disease Models, Animal; Electroretinography; Mutation; N-Methylaspartate / toxicity; Photoreceptor Cells, Vertebrate / physiology; Pipecolic Acids / toxicity; Retinal Bipolar Cells / physiology; Retinitis Pigmentosa / genetics; Retinitis Pigmentosa / physiopathology; Rhodopsin / genetics; Swine; Synapses / physiology; Synaptic Transmission / drug effects; Synaptic Transmission / physiology; Tetrodotoxin / toxicity; Vision, Ocular
TL;DR:
In Tg retinas, ectopic synapses formed between cones and rod bipolar cells probably altered signal processing of the ON-bipolar cell pathway and signal processing in inner retinal neurons was also modified.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2008 journal article
Ocular distribution and toxicity of intravitreal injection of triamcinolone acetonide in normal equine eyes
Veterinary Ophthalmology, 11, 15–19.
author keywords: horses; intravitreal; pharmacokinetics; toxicity; triamcinolone acetonide
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacokinetics; Anti-Inflammatory Agents / toxicity; Aqueous Humor / chemistry; Chromatography, High Pressure Liquid / methods; Chromatography, High Pressure Liquid / veterinary; Dose-Response Relationship, Drug; Electroretinography / veterinary; Horses / blood; Horses / metabolism; Injections / adverse effects; Injections / veterinary; Retina / drug effects; Tissue Distribution; Triamcinolone Acetonide / pharmacokinetics; Triamcinolone Acetonide / toxicity; Vitreous Body / chemistry
TL;DR:
There was no evidence of overt toxicity from intravitreal TA in normal horses and a single intravItreal injection resulted in TA ocular levels for 21 days, however, the risk for bacterial infections with intrav itreal injection or anterior chamber aspirations in horses is high.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2008 journal article
Ocular toxicity and distribution of subconjunctival and intravitreal rapamycin in horses
Journal of Veterinary Pharmacology and Therapeutics, 31(6), 511–516.
MeSH headings : Animals; Anti-Bacterial Agents / adverse effects; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / therapeutic use; Chromatography, High Pressure Liquid; Dermatitis, Phototoxic; Horses; Sirolimus / adverse effects; Sirolimus / pharmacokinetics; Sirolimus / therapeutic use; Tissue Distribution; Uveitis / drug therapy; Uveitis / veterinary
TL;DR:
Drug could be detected in both the aqueous and vitreous humor after intravitreal injection and no evidence of ocular toxicity was noted on ophthalmic examination or histopathology, suggesting a lack of RAPA phototoxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2008 journal article
Porcine global flash multifocal electroretinogram: Possible mechanisms for the glaucomatous changes in contrast response function
Vision Research, 48(16), 1726–1734.
author keywords: multifocal electroretinogram; global flash; pig; contrast; adaptation
MeSH headings : Animals; Contrast Sensitivity / physiology; Electroretinography / methods; Glaucoma / physiopathology; Glaucoma / psychology; Photic Stimulation / methods; Retina / physiopathology; Sus scrofa
TL;DR:
It is believed that the DC of the porcine global flash mfERG is mainly composed of contributions from photoreceptors, and ON- and OFF-bipolar cells, where inner retinal activity partially shaped the DC with superimposed regular wavelets.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2008 journal article
Role of bacteria in the pathogenesis of recurrent uveitis in horses from the southeastern United States
American Journal of Veterinary Research, 69(10), 1329–1335.
MeSH headings : Animals; Aqueous Humor / microbiology; Horse Diseases / microbiology; Horses; Leptospira / genetics; Leptospira / isolation & purification; Leptospirosis / microbiology; Leptospirosis / veterinary; Polymerase Chain Reaction; RNA, Ribosomal / genetics; Recurrence; Reference Values; Southeastern United States; Uveitis / microbiology; Uveitis / veterinary; Vitreous Body / microbiology
TL;DR:
In horses from the southeastern United States, Leptospira organisms may have helped initiate ERU in some, but the continued presence of the organisms did not play a direct role in the pathogenesis of this recurrent disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2007 journal article
A Pharmacokinetic and Safety Evaluation of an Episcleral Cyclosporine Implant for Potential Use in High-Risk Keratoplasty Rejection
Investigative Opthalmology & Visual Science, 48(5), 2023.
MeSH headings : Animals; Aqueous Humor / metabolism; Biological Availability; Conjunctiva / metabolism; Cornea / metabolism; Cyclosporine / pharmacokinetics; Cyclosporine / toxicity; Dogs; Drug Implants; Eyelids / metabolism; Female; Graft Rejection / prevention & control; Immunosuppressive Agents / pharmacokinetics; Immunosuppressive Agents / toxicity; Keratoplasty, Penetrating; Lymph Nodes / metabolism; Male; Rabbits; Sclera / metabolism
TL;DR:
Episcleral implants are safe and effective at delivering therapeutic CsA levels to the cornea to potentially prevent corneal allograft rejection and assess the toxicity of a cyclosporine episcleral implant for the prevention of high-risk keratoplasty rejection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2007 chapter
Corneal diseases and surgery
In K. N. Gelatt (Ed.), Veterinary Ophthalmology (4th ed.). Ames, Iowa: Blackwell Publishing.
Ed(s): K. Gelatt
Source: NC State University Libraries
Added: October 20, 2020
2007 journal article
Pharmacologically defined components of the normal porcine multifocal ERG
Documenta Ophthalmologica, 116(3), 165–176.
author keywords: adaptation; multifocal electroretinography; nonlinearity; pig; retina
MeSH headings : Aminobutyrates / pharmacology; Anesthetics, Inhalation / administration & dosage; Animals; Electroretinography / drug effects; Excitatory Amino Acid Agonists / pharmacology; Excitatory Amino Acid Antagonists / pharmacology; Injections; N-Methylaspartate / pharmacology; Pipecolic Acids / pharmacology; Receptors, N-Methyl-D-Aspartate / physiology; Retina / physiology; Retinal Bipolar Cells / physiology; Sodium Channel Blockers / pharmacology; Sodium Channels / physiology; Swine; Tetrodotoxin / pharmacology; Vitreous Body
TL;DR:
Better understanding of the cellular origins of the normal porcine mfERG will be useful for comparing and defining the functional changes that may occur in diseased retinas.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2007 journal article
Proteinases of the cornea and preocular tear film
Veterinary Ophthalmology, 10(4), 199–206.
author keywords: corneal ulceration; dog; horse; preocular tear film; proteinase inhibitors; proteinase
MeSH headings : Animals; Cats; Cornea / enzymology; Corneal Ulcer / enzymology; Corneal Ulcer / pathology; Corneal Ulcer / surgery; Corneal Ulcer / veterinary; Dogs; Horses; Matrix Metalloproteinases / metabolism; Tears / enzymology; Wound Healing
TL;DR:
In animals, successful treatment leads to a rapid reduction in tear film proteolytic activity that corresponds with the improvement in the clinical signs of corneal ulceration, and a combination of these proteinase inhibitors may be beneficial.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2007 journal article
Retinal detachment in horses: 40 cases (1998–2005)
Veterinary Ophthalmology, 10(6), 380–385.
author keywords: equine recurrent uveitis; equine; retinal detachment; trauma
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Diagnostic Techniques, Ophthalmological / veterinary; Female; Horse Diseases / diagnosis; Horse Diseases / drug therapy; Horse Diseases / epidemiology; Horse Diseases / etiology; Horses; Male; North Carolina / epidemiology; Ohio / epidemiology; Ophthalmic Solutions / administration & dosage; Ophthalmic Solutions / therapeutic use; Retinal Detachment / epidemiology; Retinal Detachment / veterinary; Retrospective Studies
TL;DR:
The visual prognosis of RD in horses is grave; however, horses with nontraumatic RD (most commonly ERU) may be able to maintain a comfortable but blind globe with anti-inflammatory medical therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2006 journal article
A Novel Bioerodible Deep Scleral Lamellar Cyclosporine Implant for Uveitis
Investigative Opthalmology & Visual Science, 47(6), 2596.
MeSH headings : Absorbable Implants / veterinary; Animals; Cyclosporine / administration & dosage; Cyclosporine / adverse effects; Cyclosporine / pharmacokinetics; Drug Delivery Systems / veterinary; Feasibility Studies; Horse Diseases / drug therapy; Horse Diseases / metabolism; Horse Diseases / pathology; Horses; Humans; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / adverse effects; Immunosuppressive Agents / pharmacokinetics; Leptospira interrogans / drug effects; Leptospira interrogans / growth & development; Microbial Sensitivity Tests; Panuveitis / drug therapy; Panuveitis / metabolism; Panuveitis / pathology; Panuveitis / veterinary; Permeability; Recurrence; Sclera / metabolism; Treatment Outcome
TL;DR:
Diffusion of CsA across the sclera from the episcleral space was not a feasible method of drug delivery to the equine eye, but placing a deep scleral lamellar C sA implant adjacent to the suprachoroidal space was effective in achieving therapeutic ocular drug concentrations and controlling uveitis in horses with ERU.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2006 journal article
Effect of ophthalmic Nd:YAG laser energy on intraocular lenses after posterior capsulotomy in normal dog eyes
Veterinary Ophthalmology, 9(5), 335–340.
author keywords: canine; Nd : YAG laser capsulotomy; posterior capsular opacity
MeSH headings : Acrylates; Animals; Dogs; Intraoperative Complications; Laser Therapy / adverse effects; Lens Capsule, Crystalline / surgery; Lenses, Intraocular; Models, Anatomic
TL;DR:
Both posterior lens capsules and Iols were disrupted in an energy-dependent manner with minimal difference in number of capsulotomy sites or damage to the IOL between acrylic and PMMA IOLs in normal canine cadaver eyes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2006 journal article
Evaluation of concentration of voriconazole in aqueous humor after topical and oral administration in horses
American Journal of Veterinary Research, 67(2), 296–301.
MeSH headings : Administration, Oral; Administration, Topical; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / adverse effects; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Aqueous Humor / chemistry; Dose-Response Relationship, Drug; Female; Horses / metabolism; Male; Pyrimidines / administration & dosage; Pyrimidines / adverse effects; Pyrimidines / blood; Pyrimidines / pharmacokinetics; Triazoles / administration & dosage; Triazoles / adverse effects; Triazoles / blood; Triazoles / pharmacokinetics; Voriconazole
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2006 journal article
Keratometry, biometry and prediction of intraocular lens power in the equine eye
Veterinary Ophthalmology, 9(5), 357–360.
author keywords: biometry; equine; intraocular lens; keratometry
MeSH headings : Animals; Animals, Newborn; Biometry; Cataract / physiopathology; Cataract / veterinary; Cataract Extraction / veterinary; Cornea / anatomy & histology; Cornea / diagnostic imaging; Female; Horse Diseases / physiopathology; Horses; Lenses, Intraocular / veterinary; Male; Postoperative Period; Ultrasonography
TL;DR:
An IOL of substantially lower diopter strength than that needed in either dogs or cats is required to achieve emmetropia after lens extraction in adult horses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2006 chapter
Surgical management of equine recurrent uveitis
In J. A. Auer & J. A. Stick (Eds.), Equine Surgery (3rd ed., pp. 749–755).
Ed(s): J. Auer & J. Stick
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: October 20, 2020
2006 journal article
Sustained Release Cyclosporine Therapy for Bilateral Keratoconjunctivitis Sicca in a Red Wolf (Canis rufus)
Journal of Zoo and Wildlife Medicine, 37(4), 562–564.
author keywords: Canis rufus; cyclosporine; dry eye; keratoconjuctivitis sicca (KCS); sustained-release delivery; red wolf
MeSH headings : Animals; Cyclosporine / therapeutic use; Drug Implants / therapeutic use; Immunosuppressive Agents / therapeutic use; Keratoconjunctivitis Sicca / drug therapy; Keratoconjunctivitis Sicca / veterinary; Male; Treatment Outcome; Wolves
TL;DR:
A 12-yr-old intact male red wolf diagnosed with bilateral idiopathic dry eye was treated with subconjunctival drug delivery implants designed to release therapeutic levels of cyclosporine from 12–24 mo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2005 journal article
Bilateral nodular lymphocytic conjunctivitis in a horse
Veterinary Ophthalmology, 8(2), 129–134.
author keywords: conjunctival mass; horse; nodular lymphoid hyperplasia
MeSH headings : Animals; Conjunctival Neoplasms / diagnosis; Conjunctival Neoplasms / veterinary; Diagnosis, Differential; Horse Diseases / diagnosis; Horse Diseases / pathology; Horses; Immunohistochemistry / veterinary; Lymphoma, B-Cell, Marginal Zone / diagnosis; Lymphoma, B-Cell, Marginal Zone / veterinary; Male
TL;DR:
This is the first reported case of bilateral nodular lymphocytic conjunctivitis in a horse and for which surgical excision alone was not curative.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2005 book
TL;DR:
The horse has a total visual field of nearly 360°, meaning a horse can just about see its tail with its head pointed forward, and Rods significantly outnumber cones, indicating the high capacity for night vision in horses, but cones are present in the horse retina with the capacity for color vision.
(via Semantic Scholar)
Source: NC State University Libraries
Added: December 30, 2020
2005 article
Equine Recurrent Uveitis
Equine Ophthalmology, pp. 285–322.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: September 9, 2019
2005 journal article
Immune-mediated keratitis in horses: 19 cases (1998-2004)
Veterinary Ophthalmology, 8(4), 233–239.
author keywords: cornea; equine; immune-mediated diseases; keratitis
MeSH headings : Animals; Cyclosporine / administration & dosage; Dexamethasone / administration & dosage; Female; Horse Diseases / epidemiology; Horse Diseases / etiology; Horse Diseases / pathology; Horse Diseases / therapy; Horses; Immunosuppressive Agents / administration & dosage; Keratitis / epidemiology; Keratitis / veterinary; Male; North Carolina / epidemiology; Ophthalmic Solutions / administration & dosage; Ophthalmologic Surgical Procedures / veterinary; Records / veterinary; Retrospective Studies; Severity of Illness Index
TL;DR:
Clinical and histologic findings, treatment, and outcome of horses with suspected immune-mediated keratitis (IMMK) are described, with horses with superficial IMMK responding to topical medical therapy, but responded best to surgical removal of the lesion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2005 journal article
Ocular parameters related to drug delivery in the canine and equine eye: aqueous and vitreous humor volume and scleral surface area and thickness
Veterinary Ophthalmology, 8(4), 265–269.
author keywords: aqueous; canine; drug delivery; equine; scleral thickness; vitreous
MeSH headings : Animals; Aqueous Humor; Dogs / anatomy & histology; Drug Delivery Systems / veterinary; Horses / anatomy & histology; Ophthalmic Solutions / administration & dosage; Reference Values; Sclera / anatomy & histology; Vitreous Body / anatomy & histology
TL;DR:
The UBM measurement method appeared to be most consistent and reproducible when compared to direct measurement techniques and associated with significantly thinner scleral tissue than with fresh ocular tissue.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2005 journal article
Preclinical Evaluation of a Novel Episcleral Cyclosporine Implant for Ocular Graft-Versus-Host Disease
Investigative Opthalmology & Visual Science, 46(2), 655.
MeSH headings : Animals; Biological Availability; Cyclosporine / pharmacokinetics; Cyclosporine / pharmacology; Cyclosporine / toxicity; Dogs; Drug Evaluation, Preclinical; Drug Implants; Electroretinography / drug effects; Eye / metabolism; Eye / pathology; Female; Graft vs Host Disease / pathology; Graft vs Host Disease / prevention & control; Immunosuppressive Agents / pharmacokinetics; Immunosuppressive Agents / pharmacology; Immunosuppressive Agents / toxicity; Keratoconjunctivitis / drug therapy; Keratoconjunctivitis / pathology; Male; Rabbits; Retina / drug effects; Safety; Sclera / drug effects; Sclera / metabolism; Sclera / pathology
TL;DR:
The episcleral cyclosporine implant shows promise in reducing the morbidity associated with lacrimal gland graft-versus-host disease after allogeneic hematopoietic stem cell transplantation and may have potential in treating other ocular inflammatory diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2005 journal article
Surgical Removal of Cataracts Due to Diplostomum Species in Gulf Sturgeon (Acipenser oxyrinchus desotoi)
Journal of Zoo and Wildlife Medicine, 36(3), 504–508.
author keywords: Acipenser oxyrinchus desotoi; cataract surgery; Diplostomum sp.; fish; Gulf sturgeon; trematode
MeSH headings : Animals; Animals, Wild / parasitology; Animals, Wild / surgery; Cataract / etiology; Cataract / parasitology; Cataract Extraction / methods; Cataract Extraction / veterinary; Fish Diseases / parasitology; Fish Diseases / surgery; Fishes; Trematode Infections / complications; Trematode Infections / surgery; Trematode Infections / veterinary
TL;DR:
This report is the first known report of surgical correction of cataracts in sturgeon species, and it also is theFirst known attempt to correct vision problems in fish being returned to the wild.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2004 journal article
Cosmetic globe surgery in the horse
Veterinary Clinics of North America: Equine Practice, 20(2), 467–484.
MeSH headings : Animals; Blindness / prevention & control; Blindness / surgery; Blindness / veterinary; Contact Lenses / veterinary; Diagnostic Techniques, Ophthalmological / veterinary; Eye Diseases / surgery; Eye Diseases / veterinary; Eye, Artificial / veterinary; Horse Diseases / surgery; Horses; Pain / prevention & control; Pain / surgery; Pain / veterinary; Prostheses and Implants / veterinary; Surgery, Plastic / veterinary
TL;DR:
Options available for improved cosmetic outcome in horses with ocular scars or requiring enucleation are addressed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2004 journal article
Equine glaucoma
Veterinary Clinics of North America: Equine Practice, 20(2), 381–391.