Brian C Gilger

Ocular immunology, pharmacology, drug delivery, gene therapy

Dr. Gilger is a native of Akron, Ohio and received his veterinary degree from the Ohio State University in Columbus, Ohio. After a one-year internship at the Animal Medical Center in New York City, Dr. Gilger worked in a general small animal practice in Atlanta, Georgia. Following a 3 year ophthalmology residency and masters degree at Auburn University in Alabama, Dr. Gilger returned to the Ohio State University as an Assistant Professor of Ophthalmology In 1992. In October 1995, Dr. Gilger joined the faculty at NC State University. His clinical interests include intraocular surgery such as cataract surgery, dry eye treatment and equine ocular disorders. His main research interest is ocular pharmacology, drug delivery, and ocular immunology.

Works (291)

Updated: March 24th, 2025 05:01

2025 journal article

Uveitis and blindness in a closed herd of Equidae following leptospiral infection

FRONTIERS IN VETERINARY SCIENCE, 11.

By: J. Gerras n, K. Young n, D. Roberts n, G. Waldman, J. Salmon n & B. Gilger n

author keywords: horse; uveitis; leptospirosis; environment; susceptibility
topics (OpenAlex): Leptospirosis research and findings; Viral Infections and Vectors; Bartonella species infections research
Sources: Web Of Science, NC State University Libraries
Added: January 27, 2025

2024 journal article

A chimeric anti-vascularization immunomodulator prevents high-risk corneal transplantation rejection via ex vivo gene therapy

Molecular Therapy, 32(11), 4006–4020.

By: B. Gilger n, T. Hasegawa*, R. Sutton*, J. Bower*, C. Li* & M. Hirsch*

topics (OpenAlex): Reproductive System and Pregnancy; RNA Interference and Gene Delivery; Corneal Surgery and Treatments
Sources: Web Of Science, NC State University Libraries, Crossref
Added: November 18, 2024

2024 journal article

Causes, treatment, and outcome of hyphema, fibrin, and vitreal hemorrhage in horses: 219 cases (2012–2023)

Journal of the American Veterinary Medical Association, 262(S2), S94–S101.

By: J. Gould n, M. Wells n, M. de Linde Henriksen n & B. Gilger n

author keywords: equine; hyphema; fibrin; tissue plasminogen activator; uveitis
topics (OpenAlex): Venous Thromboembolism Diagnosis and Management; Veterinary Equine Medical Research; Trauma, Hemostasis, Coagulopathy, Resuscitation
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Web Of Science, Crossref, NC State University Libraries
Added: August 1, 2024

2024 journal article

Cold atmospheric plasma inactivates<i> Aspergillus</i><i> flavus</i> and Fusarium keratoplasticum biofilms and conidia in vitro

JOURNAL OF MEDICAL MICROBIOLOGY, 73(7).

By: D. Roberts n, J. Thomas n, J. Salmon n, M. Cubeta n, K. Stapelmann n & B. Gilger n

author keywords: antifungal; Aspergillus; cold atmospheric plasma; Fusarium; fungal disease.
topics (OpenAlex): Plasma Applications and Diagnostics; Ocular Surface and Contact Lens; Ocular Infections and Treatments
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 15, 2024

2024 journal article

Current therapy and advancements in the treatment of equine fungal keratitis

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 262, S65–S73.

By: D. Roberts n & B. Gilger n

author keywords: fungal keratitis; ulcerative keratitis; Fusarium; Aspergillus; azole
topics (OpenAlex): Ocular Infections and Treatments; Antifungal resistance and susceptibility; Essential Oils and Antimicrobial Activity
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 15, 2024

2024 journal article

Ocular toxicity, distribution, and shedding of intravitreal AAV-eqIL-10 in horses

Molecular Therapy - Methods & Clinical Development, 32(4), 101360.

By: K. Young n, T. Hasegawa*, N. Vridhachalam*, N. Henderson n, J. Salmon n, T. McCall*, M. Hirsch*, B. Gilger n

topics (OpenAlex): Retinal Diseases and Treatments; Corneal Surgery and Treatments
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: December 2, 2024

2024 journal article

Relationship between stable management practices and ocular disease in horses

Equine Veterinary Education.

By: C. Ludwig n, E. Barr n & B. Gilger n

author keywords: horse; corneal ulcer; face mask; hay; owner survey
topics (OpenAlex): Veterinary Equine Medical Research; Ocular Infections and Treatments; Plant Toxicity and Pharmacological Properties
TL;DR: Horses kept primarily at pasture have fewer ocular diseases, likely because they sustain less ocular trauma compared to horses kept in stables, and how hay is fed does not correlate with the incidence of corneal or other ocular disease. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: March 8, 2024

2024 journal article

Treatment of equine keratomycosis, part 1: selection of appropriate therapy based on clinical presentation and diagnostic testing improves clinical outcomes

Journal of the American Veterinary Medical Association, 262(S2), S74–S84.

By: H. Smith n, K. Love, A. Antezana n, E. Barr n, B. Gilger n & A. Oh n

author keywords: equine; cornea; keratomycosis; corneal ulcer; stromal abscess
topics (OpenAlex): Ocular Infections and Treatments; Antifungal resistance and susceptibility; Infectious Diseases and Mycology
Sources: ORCID, Web Of Science, Crossref, NC State University Libraries
Added: October 23, 2024

2024 journal article

Treatment of equine keratomycosis, part 2: reporting common systemic and ocular complications to enhance decision-making for equine clinicians and owners

Journal of the American Veterinary Medical Association, 262(S2), S85–S93.

By: H. Smith n, K. Love, A. Antezana n, E. Barr n, B. Gilger n & A. Oh n

author keywords: equine; cornea; keratomycosis; corneal ulcer; stromal abscess
topics (OpenAlex): Ocular Infections and Treatments; Ocular Surface and Contact Lens; Corneal Surgery and Treatments
Sources: ORCID, Web Of Science, Crossref, NC State University Libraries
Added: October 28, 2024

2024 journal article

Ultrasound biomicroscopic imaging parameters associated with outcome in equine infectious ulcerative keratitis and stromal abscesses

Journal of the American Veterinary Medical Association, 262(S2), S57–S64.

By: E. Collins n, E. Barr n, H. Westermeyer n, B. Gilger n & A. Oh n

author keywords: ultrasound biomicroscopy; aqueous humor; cell count; infectious keratitis; stromal abscess
topics (OpenAlex): Veterinary Equine Medical Research; Ocular Infections and Treatments; Corneal surgery and disorders
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Web Of Science, Crossref, NC State University Libraries
Added: June 1, 2024

2024 chapter

Vision and Disorders of Vision in Performance Horses

In Equine Sports Medicine and Surgery (pp. 1118–1130).

By: B. Gilger* & A. Matthews

topics (OpenAlex): Veterinary Equine Medical Research; Entomological Studies and Ecology; Plant Toxicity and Pharmacological Properties
Sources: Crossref, NC State University Libraries
Added: March 11, 2025

2023 conference paper

AAV gene therapy for the treatment of uveitis

International Society for Eye research. Presented at the International Society for Eye research, Gold Coast, Australia.

By: B. Gilger

Source: NC State University Libraries
Added: February 16, 2025

2023 journal article

AAV-mediated expression of HLA-G for the prevention of experimental ocular graft vs. host disease

Molecular Therapy - Methods & Clinical Development, 29, 227–235.

By: J. Nilles n, D. Roberts n, J. Salmon n, L. Song*, C. O’Dea*, L. Marjoram*, J. Bower*, M. Hirsch*, B. Gilger n

topics (OpenAlex): Reproductive System and Pregnancy; Sperm and Testicular Function; Corneal Surgery and Treatments
TL;DR: Evidence is provided that subconjunctival AAV targets ocular surface and corneal disease and support that HLA-G-based gene therapy may be an effective treatment for OGvHD. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: March 24, 2023

2023 journal article

Additional evidence supports <scp><i>GRM6</i></scp> p.<scp>Thr178Met</scp> as a cause of congenital stationary night blindness in three horse breeds

Veterinary Ophthalmology, 10.

By: E. Esdaile*, K. Knickelbein*, C. Donnelly*, M. Ferneding*, M. Motta*, B. Story*, F. Avila*, C. Finno* ...

author keywords: allele frequency; CSNB; CSNB2; equine genetics; glutamate metabotropic receptor 6; night blind
topics (OpenAlex): Retinal Development and Disorders; Photoreceptor and optogenetics research; Neuroscience and Neuropharmacology Research
TL;DR: This study represents the largest across-breed identification of CSNB in the horse and suggests that this disorder is likely underdiagnosed. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: October 30, 2023

2023 journal article

Application of Noggin-Coated Electrospun Scaffold in Corneal Wound Healing

Translational Vision Science & Technology, 12(8), 15.

By: N. Mahmood n, E. Sefat n, D. Roberts n, B. Gilger n & J. Gluck n

topics (OpenAlex): Corneal Surgery and Treatments; Electrospun Nanofibers in Biomedical Applications; Ocular Surface and Contact Lens
TL;DR: This Noggin-coated electrospun scaffold represents a step toward, expanding treatment options for patients with indolent corneal ulcers, and provides a better perspective for understanding electroSpun scaffolds as a tunable platform to infuse topical therapeutics and use as aCorneal bandage. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: October 4, 2023

2023 journal article

Effect of gentamicin on <scp>CD3</scp>+ T‐lymphocyte proliferation for treatment of equine recurrent uveitis: An in vitro study

Veterinary Ophthalmology, 26(4), 347–354.

By: H. Smith n, A. Berglund n, J. Robertson n, L. Schnabel n, R. McMullen*, B. Gilger n, A. Oh n

author keywords: autoimmune disease; equine recurrent uveitis; gentamicin; horse; immunology; intravitreal injection
topics (OpenAlex): Ocular Infections and Treatments; Mycobacterium research and diagnosis
TL;DR: Gentamicin had no effect on equine peripheral blood CD3+ T-lymphocyte cell viability and proliferation in concentrations ranging from "safe" to "retinotoxic" in relation to intravitreal injection volumes. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: April 29, 2023

2023 conference paper

Enhanced retinal transduction and immune evasion of a novel Adeno-Associated viral vector following intravitreal Injection

International Society for Eye Research. Presented at the International Society for Eye Research, Gold Coast, Australia. Feb.

By: B. Gilger, K. Secamiglio, L. Marjoram, D. Culp, C. Li & M. Hirsch

Source: NC State University Libraries
Added: February 16, 2025

2023 conference paper

Evaluation and predictive value of ultrasound biomicroscopy imaging parameters on equine corneal diseases

American College of Veterinary Ophthalmologists. Presented at the American College of Veterinary Ophthalmologists, Boston MA.

By: E. Wise, A. Oh & B. Gilger

Source: NC State University Libraries
Added: February 16, 2025

2023 journal article

Ex vivo analysis of ultraviolet radiation transmission through ocular media and retina in select species

Experimental Eye Research, 233, 109550.

By: N. Himebaugh n, J. Robertson n, K. Weninger n, B. Gilger n, B. Ekesten* & A. Oh n

author keywords: Ultraviolet radiation; Ocular media; Canine; Feline; Human; Vision
topics (OpenAlex): Intraocular Surgery and Lenses; Connexins and lens biology; Ocular and Laser Science Research
TL;DR: The globes of cats and dogs allowed the most amount of UV radiation transmission, while those of pigs and humans allowed the least amount ofUV radiation transmission. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: June 25, 2023

2023 conference paper

Longitudinal study on the effect of leptospiral vaccination on uveitis on a single farm: the paradox study

International equine ophthalmology consortium symposium. Presented at the International equine ophthalmology consortium symposium, Edinburg, UK.

By: J. Gerras, G. Waldman, K. Young, J. Salmon & B. Gilger

Source: NC State University Libraries
Added: February 16, 2025

2023 article

Phase-Dependent Differential In Vitro and Ex Vivo Susceptibility of Aspergillus flavus and Fusarium keratoplasticum to Azole Antifungals

Roberts, D., Salmon, J., Cubeta, M. A., & Gilger, B. C. (2023, September 6).

By: D. Roberts n, J. Salmon n, M. Cubeta n & B. Gilger n

topics (OpenAlex): Ocular Infections and Treatments; Ocular Surface and Contact Lens; Antifungal resistance and susceptibility
Source: ORCID
Added: September 11, 2023

2023 journal article

Phase-Dependent Differential In Vitro and Ex Vivo Susceptibility of Aspergillus flavus and Fusarium keratoplasticum to Azole Antifungals

Journal of Fungi, 9(10), 966.

By: D. Roberts n, J. Salmon n, M. Cubeta n & B. Gilger n

author keywords: Aspergillus; Fusarium; fungal keratitis; antifungal susceptibility; MIC; azole
topics (OpenAlex): Ocular Infections and Treatments; Ocular Surface and Contact Lens; Antifungal resistance and susceptibility
TL;DR: It is concluded that traditional antifungal susceptibility testing with conidial suspensions does not correlate with fungal susceptibility in cultures of a more advanced developmental phase, and a revised method of antif fungus susceptibility testing that evaluates hyphal susceptibility may better predict fungal response in the clinical setting where treatment is often delayed until days after the initial insult. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: September 27, 2023

2023 journal article

Prevalence, differences, and potential correlation to age, sex, breed, coat color, iris color, and geographic location in naturally occurring refractive errors in the normal equine eye from Germany and North Carolina

Veterinary Ophthalmology, 26(4), 297–305.

By: L. Charnock*, M. Davidson n, D. Keys*, B. Gilger n & R. McMullen*

author keywords: ametropia; astigmatism; emmetropia; equine ophthalmology; refraction; streak retinoscopy
topics (OpenAlex): Ocular Infections and Treatments; Intraocular Surgery and Lenses; Ophthalmology and Visual Impairment Studies
TL;DR: Most eyes evaluated are emmetropic, or shifted myopically, with excellent agreement between eyes of the same horse, and sex, iris color, and geographic location appear to impact refraction in horses. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: January 25, 2023

2023 article

Relationship between stable management practices and ocular disease in horses

Ludwig, C., Barr, E., & Gilger, B. (2023, October 18).

By: C. Ludwig n, E. Barr n & B. Gilger n

topics (OpenAlex): Plant Toxicity and Pharmacological Properties; Veterinary Equine Medical Research; Entomological Studies and Ecology
Source: ORCID
Added: November 3, 2023

2023 journal article

Solving an eye condition by looking to the rear

Equine Veterinary Education, 35(7), 356–357.

By: B. Gilger n

topics (OpenAlex): Ocular Infections and Treatments; Plant Toxicity and Pharmacological Properties; Corneal Surgery and Treatments
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: March 14, 2023

2023 journal article

Use of Biologics and Stem Cells in Equine Ophthalmology

VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE, 39(3), 541–552.

By: B. Gilger n

author keywords: Equine; Eye; Stem cells; Gene therapy; Biologics
topics (OpenAlex): Corneal Surgery and Treatments; Wound Healing and Treatments; Periodontal Regeneration and Treatments
TL;DR: The use of stem cells or gene therapy has promise for the treatment of Intraocular diseases such as equine recurrent uveitis by providing efficacious, practical, and long-term therapy for these blinding diseases. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 4, 2023

2023 conference paper

Use of H-Fire for treatment of an unusual eyelid mass in a horse

International equine ophthalmology consortium symposium. Presented at the International equine ophthalmology consortium symposium, Edinburg, UK.

By: T. Stonex & B. Gilger

Source: NC State University Libraries
Added: February 16, 2025

2022 conference paper

Additional Evidence Supports GRM6 p.Thr178Met as a Cause of Congenital Stationary Night Blindness in Two Horse Breeds

Plant and Animal Genome Conference. Presented at the Plant and Animal Genome Conference, San Diego, CA.

By: E. Esdaile, K. Knickelbein, C. Donnelly, M. Ferneding, M. Hammond, F. Avila, C. Finno, B. Gilger ...

Source: NC State University Libraries
Added: February 16, 2025

2022 journal article

Developing advanced therapeutics through the study of naturally occurring immune-mediated ocular disease in domestic animals

AMERICAN JOURNAL OF VETERINARY RESEARCH, 83(11).

By: B. Gilger n

MeSH headings : Horses; Animals; Humans; Rats; Cats; Dogs; Animals, Domestic; Eye; Mesenchymal Stem Cells; Keratitis / metabolism; Keratitis / veterinary; Uveitis / therapy; Uveitis / veterinary; Cat Diseases; Dog Diseases / metabolism; Horse Diseases / therapy; Horse Diseases / metabolism; Rodent Diseases / metabolism
topics (OpenAlex): Immunotherapy and Immune Responses; Corneal Surgery and Treatments; Cytomegalovirus and herpesvirus research
TL;DR: Results support that autologous subconjunctival BM-MSC therapy may be a viable treatment alternative for IMMK and that the use of subconJunctival MSCs may be an effective method to treat ocular surface immune-mediated diseases in humans and other species. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: December 5, 2022

2022 chapter

Diseases of the Uvea, Uveitis, and Recurrent Uveitis

In B. C. Gilger (Ed.), Equine Ophthalmology (4th ed., pp. 441–498).

By: B. Gilger*, R. Degroote & C. Deeg

Ed(s): B. Gilger*

topics (OpenAlex): Toxoplasma gondii Research Studies; Ocular Infections and Treatments; Yersinia bacterium, plague, ectoparasites research
Sources: NC State University Libraries, NC State University Libraries
Added: February 2, 2024

2022 conference paper

Effect of gentamicin on CD3+ T-lymphocyte proliferation and cell viability for treatment of recurrent uveitis in horses: A pilot study

International equine ophthalmology consortium symposium. Presented at the International equine ophthalmology consortium symposium, Louisville, KY.

By: H. Smith, A. Berglund, L. Schnabel, R. McMullen, B. Gilger & A. Oh

Source: NC State University Libraries
Added: February 16, 2025

2022 book

Equine Ophthalmology

Brian Gilger

Ed(s): B. Gilger

topics (OpenAlex): Intraocular Surgery and Lenses
Source: Crossref
Added: November 8, 2023

2022 chapter

Equine uveitis

In B. C. Gilger (Ed.), Equine Ophthalmology (4th ed.). Ames, IA: Wiley Blackwell.

By: B. Gilger

Ed(s): B. Gilger

Source: NC State University Libraries
Added: February 16, 2025

2022 conference paper

Ex Vivo Analysis of Ultraviolet Light Transmission in Select Species

Association for Research in Vision and Ophthalmology Annual Meeting. Presented at the Association for Research in Vision and Ophthalmology Annual Meeting, Denver, CO.

By: N. Himebaugh, B. Ekesten, K. Weninger, B. Gilger & A. Oh

Source: NC State University Libraries
Added: February 16, 2025

2022 journal article

How study of naturally occurring ocular disease in animals improves ocular health globally

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 260(15), 1887–1893.

By: B. Gilger n

MeSH headings : Humans; Horses; Cats; Animals; Dogs; Eye; Uveitis / epidemiology; Uveitis / therapy; Uveitis / veterinary; Glaucoma / veterinary; Retinal Diseases / veterinary; Corneal Ulcer / veterinary; Cat Diseases; Dog Diseases / epidemiology; Dog Diseases / therapy; Horse Diseases / pathology
topics (OpenAlex): Corneal Surgery and Treatments; Rabies epidemiology and control; Ocular Surface and Contact Lens
TL;DR: The role of naturally occurring ocular disease in animals is reviewed with emphasis on how the understanding of these ocular diseases contributes to one health initiatives, particularly the pathogenesis and treatment of ocular Diseases common to animals and humans. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023

2022 article

Induced Pluripotent Stem Cell-Derived Corneal Cells: Current Status and Application

Mahmood, N., Suh, T. C., Ali, K. M., Sefat, E., Jahan, U. M., Huang, Y., … Gluck, J. M. (2022, August 1). STEM CELL REVIEWS AND REPORTS, Vol. 8.

By: N. Mahmood n, T. Suh n, K. Ali n, E. Sefat n, U. Jahan n, Y. Huang n, B. Gilger n, J. Gluck n

author keywords: Cornea; Corneal tissue engineering; Induced pluripotent stem cells; Differentiation; Limbal stem cell deficiency
MeSH headings : Humans; Induced Pluripotent Stem Cells; Cell Differentiation / genetics; Cornea; Cell Line; Corneal Diseases / therapy
topics (OpenAlex): Corneal Surgery and Treatments; Pluripotent Stem Cells Research; Developmental Biology and Gene Regulation
TL;DR: The early development of the cornea is discussed because protocols differentiating iPSCs toward corneal lineages rely heavily upon recapitulating this development, and differentiated iPSC phenotypes have been analyzed with an emphasis on feeder- free, xeno-free, and well-defined protocols, which have clinical relevance. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 1, 2022

2022 journal article

Inhibition of experimental autoimmune uveitis by intravitreal AAV-Equine-IL10 gene therapy

PLOS ONE, 17(8).

Ed(s): A. Taylor

MeSH headings : Animals; Autoimmune Diseases; Dependovirus / genetics; Genetic Therapy; Horses / genetics; Humans; Interleukin-10 / genetics; Interleukin-10 / therapeutic use; Rats; Uveitis
topics (OpenAlex): Virus-based gene therapy research; Herpesvirus Infections and Treatments
TL;DR: Safety and efficacy of AAV8-Equine-IL10 to prevent EAU are demonstrated and support continued exploration of A AV gene therapy for the treatment of equine and perhaps human recurrent uveitis. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 19, 2022

2022 journal article

Peptide Inhibitors of MARCKS Suppress Endotoxin Induced Uveitis in Rats

Journal of Ocular Pharmacology and Therapeutics, 38(3), 223–231.

By: T. Stonex n, J. Salmon n, K. Adler n & B. Gilger n

topics (OpenAlex): Neutrophil, Myeloperoxidase and Oxidative Mechanisms; Research on Leishmaniasis Studies
Sources: Crossref, NC State University Libraries
Added: February 2, 2024

2022 journal article

Polidocanol monotherapy for a superficial orbital venous malformation in a horse

Veterinary Ophthalmology, 25(5), 412–418.

By: T. Stonex n, A. Zibura n, M. Andres n, B. Gilger n & A. Oh n

author keywords: horse; monotherapy; orbit; polidocanol; sclerotherapy; venous malformation
MeSH headings : Animals; Horse Diseases / chemically induced; Horse Diseases / diagnostic imaging; Horse Diseases / drug therapy; Horses; Male; Orbital Diseases / veterinary; Polidocanol / therapeutic use; Polyethylene Glycols; Sclerosing Solutions / adverse effects; Sclerosing Solutions / therapeutic use; Sclerotherapy / veterinary; Treatment Outcome; Veins / abnormalities
topics (OpenAlex): Vascular Malformations and Hemangiomas; Urologic and reproductive health conditions; Ocular Surface and Contact Lens
TL;DR: Polidocanol as the sole treatment for a superficial orbital venous malformation in a horse was well tolerated and led to clinical resolution, and sclerosant monotherapy may be a safe treatment option for superficial orbital Venous malformations. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: June 2, 2022

2022 review

Therapeutic Applications of Adeno-Associated Virus (AAV) Gene Transfer of HLA-G in the Eye

[Review of ]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(7).

By: B. Gilger n & M. Hirsch*

author keywords: AAV; HLA-G; dry eye; ocular graft vs; host disease; corneal transplant rejection; uveitis; gene therapy
MeSH headings : Animals; Choroidal Neovascularization / genetics; Dependovirus / genetics; Genetic Therapy; Genetic Vectors / genetics; HLA-G Antigens / genetics
topics (OpenAlex): Reproductive System and Pregnancy; Corneal Surgery and Treatments; Immunotherapy and Immune Responses
TL;DR: AAV-mediated gene transfer of HLA-G may be an effective treatment for common immune-mediated, inflammatory, and neovascular diseases of the eye. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 28, 2022

2022 conference paper

Topical peptide inhibitors of MARCKS reduce signs of dry eye in the alacrimal rat model

Association for Research in Vision and Ophthalmology Annual Meeting. Presented at the Association for Research in Vision and Ophthalmology Annual Meeting, Denver, CO.

By: B. Gilger, J. Salmon & K. Adler

Source: NC State University Libraries
Added: February 16, 2025

2022 chapter

Vision and vision disorders in performance horses

In K. W. Hinchcliff, A. J. Kaneps, R. J. Geor, & E. van Erck-Westergen (Eds.), Equine sports medicine and surgery : basic and clinical sciences of the equine athlete. (3rd ed.). Philadelphia, PA: Saunders.

By: B. Gilger

Ed(s): K. Hinchcliff, A. Kaneps, R. Geor & E. van Erck-Westergen

Source: NC State University Libraries
Added: February 2, 2024

2021 journal article

A defect in the NOG gene increases susceptibility to spontaneous superficial chronic corneal epithelial defects (SCCED) in boxer dogs

BMC Veterinary Research, 17(1).

By: K. Meurs n, K. Montgomery n, S. Friedenberg*, B. Williams n & B. Gilger*

author keywords: Corneal ulcer; Chronic; Superficial; Recurrent erosion; NOG; Boxer
MeSH headings : Animals; Bone Morphogenetic Proteins / genetics; Bone Morphogenetic Proteins / metabolism; Chronic Disease; Corneal Diseases / veterinary; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Epithelium, Corneal / pathology; Gene Expression Regulation; Genetic Predisposition to Disease; Whole Genome Sequencing
topics (OpenAlex): Corneal Surgery and Treatments; Corneal surgery and disorders; Ocular Surface and Contact Lens
TL;DR: Many Boxer dogs with SCCED have a genetic defect in NOG, a constitutive protein in the cornea which is a potent inhibitor of BMP, which likely regulate limbal epithelial progenitor cells (LEPC). (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 9, 2021

2021 journal article

Efficacy and safety of suprachoroidal triamcinolone injection in horses with poorly responsive equine recurrent uveitis

Veterinary Ophthalmology, 24(3), 308–312.

By: N. Gagnon n, C. Hartley* & B. Gilger n

author keywords: horse; recurrent; retrospective; suprachoroidal; triamcinolone; uveitis
MeSH headings : Animals; Anti-Inflammatory Agents / administration & dosage; Anti-Inflammatory Agents / therapeutic use; Choroid; Female; Horse Diseases / drug therapy; Horses; Injections / veterinary; Male; Records / veterinary; Recurrence; Retrospective Studies; Treatment Outcome; Triamcinolone / administration & dosage; Triamcinolone / therapeutic use; Uveitis / drug therapy; Uveitis / veterinary
topics (OpenAlex): Ocular Infections and Treatments; Natural product bioactivities and synthesis
TL;DR: SCS TA injections appear to be a safe and possible effective treatment modality for managing poorly responsive ERU; further clinical study is warranted. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: April 1, 2021

2021 personal communication

Response to comments on 'Whole-genome sequencing identifies missense mutation in GRM6 as the likely cause of congenital stationary night blindness in a Tennessee Walking Horse'

Gilger, B., & Bellone, R. R. (2021, November).

By: B. Gilger n & R. Bellone*

MeSH headings : Animals; Eye Diseases, Hereditary / veterinary; Genetic Diseases, X-Linked; Horse Diseases / genetics; Horses; Mutation, Missense; Myopia; Night Blindness / genetics; Night Blindness / veterinary; Tennessee
topics (OpenAlex): melanin and skin pigmentation
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: October 18, 2021

2021 journal article

Role of <i>Leptospira</i> spp. testing and ocular examination in horses with equine recurrent uveitis: A retrospective study of 63 horses

Equine Veterinary Education, 34(11).

By: N. Himebaugh n & B. Gilger n

author keywords: horse; uveitis; leptospirosis; titres; PCR
topics (OpenAlex): Leptospirosis research and findings
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 30, 2021

2021 journal article

Tolerability, pharmacokinetics, and pharmacodynamics of a brinzolamide episcleral sustained release implant in normotensive New Zealand white rabbits

Journal of Drug Delivery Science and Technology, 61, 102123.

By: S. Smith n, J. Salmon n, S. Abbaraju, R. Amin & B. Gilger n

author keywords: Glaucoma; Sustained-release; Episcleral; Brinzolamide; Rabbit; Tolerability
topics (OpenAlex): Glaucoma and retinal disorders; Retinal Diseases and Treatments; Intraocular Surgery and Lenses
TL;DR: Episcleral brinzolamide-loaded silicone-matrix implants were extremely well tolerated and delivered sustained drug levels and therapeutic effect for up to 28 days in a rabbit model with an estimated duration of delivery of greater than 12 months. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: September 29, 2020

2021 book

Veterinary Ophthalmology

(6th ed.). Hoboken, NJ: Wiley.

Brian Gilger

Ed(s): K. Gelatt, G. Ben-Shlomo, B. Gilger, D. Hendrix, T. Kern & C. Plummer

Source: NC State University Libraries
Added: February 2, 2024

2021 journal article

Whole-genome sequencing identifies missense mutation inGRM6as the likely cause of congenital stationary night blindness in a Tennessee Walking Horse

EQUINE VETERINARY JOURNAL, 53(2), 316–323.

By: Y. Hack*, E. Crabtree n, F. Avila*, R. Sutton*, R. Grahn*, A. Oh n, B. Gilger n, R. Bellone*

author keywords: horse; congenital stationary night blindness (CSNB); genetics; genomics; Tennessee Walking Horse; GRM6
MeSH headings : Animals; Eye Diseases, Hereditary / genetics; Eye Diseases, Hereditary / veterinary; Genetic Diseases, X-Linked; Horse Diseases / genetics; Horses; Mutation, Missense; Myopia; Night Blindness / genetics; Night Blindness / veterinary; Receptors, Glutamate / genetics; Tennessee
topics (OpenAlex): Connexins and lens biology; Retinal Development and Disorders; Photoreceptor and optogenetics research
TL;DR: A likely causal recessive missense variant in metabotropic glutamate receptor 6 (GRM6) is identified, which alters GRM6 binding, and thus signaling from the retinal rod cell to the ON-bipolar cell, impairing vision in low light conditions. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 17, 2020

2020 journal article

A Fixed-Depth Microneedle Enhances Reproducibility and Safety for Corneal Gene Therapy

CORNEA, 39(3), 362–369.

By: B. Gilger n, E. Crabtree n, L. Song*, T. Llanga*, M. Cullen n, A. Blanchard n, J. Salmon n, S. Patel, V. Zarnitsyn, M. Hirsch*

author keywords: cornea; stromal; gene therapy; safety
MeSH headings : Animals; Corneal Stroma / metabolism; Dependovirus / genetics; Gene Expression; Gene Transfer Techniques; Genetic Therapy / methods; Genetic Vectors; Green Fluorescent Proteins / genetics; Injections, Intraocular; Male; Microscopy, Confocal; Needles; Rabbits; Reproducibility of Results; Swine; Ultrasonography
topics (OpenAlex): Virus-based gene therapy research; RNA Interference and Gene Delivery; Herpesvirus Infections and Treatments
TL;DR: This research presents a novel probabilistic approach that allows us to assess the importance of knowing the carrier and removal status of canine coronavirus as a source of infection in animals and its role in the immune system is investigated. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: May 18, 2020

2020 chapter

Acquired ocular disease in foals – the first 30 days

In Foal Diseases.

By: S. Smith & B. Gilger

Source: NC State University Libraries
Added: February 2, 2024

2020 journal article

Adeno-Associated Virus Mediated Gene Therapy for Corneal Diseases

Pharmaceutics, 12(8), 767.

By: P. Bastola*, L. Song*, B. Gilger n & M. Hirsch*

author keywords: adeno-associated viruses; cornea; corneal diseases; AAV gene therapy; rAAV
topics (OpenAlex): Virus-based gene therapy research; RNA Interference and Gene Delivery; CRISPR and Genetic Engineering
TL;DR: This current review seeks to summarize the development of AAV gene therapy, highlight preclinical efficacy studies, and discuss potential applications and challenges of this technology for targeting corneal diseases. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: September 14, 2020

2020 journal article

Improving Corneal Wound Healing after Chemical Injury with Novel Therapeutic Glycopolymers

Toxicology Letters, 331, 16.

By: S. Baker*, A. Loughran*, W. Wiesmann*, B. Gilger n & C. Ryan*

topics (OpenAlex): Corneal Surgery and Treatments; Wound Healing and Treatments
Sources: Web Of Science, NC State University Libraries, Crossref
Added: November 16, 2020

2020 journal article

In vitro susceptibility of <i>Aspergillus</i> and <i>Fusarium</i> associated with equine keratitis to new antifungal drugs

Veterinary Ophthalmology, 23(5), 918–922.

By: D. Roberts n, H. Cotter n, M. Cubeta n & B. Gilger n

author keywords: Aspergillus; Fusarium; luliconazole; voriconazole
MeSH headings : Animals; Antifungal Agents / pharmacology; Antifungal Agents / therapeutic use; Aspergillus / drug effects; Eye Infections, Fungal / drug therapy; Eye Infections, Fungal / microbiology; Eye Infections, Fungal / veterinary; Female; Fusarium / drug effects; Horse Diseases / drug therapy; Horse Diseases / microbiology; Horses; Imidazoles / pharmacology; Imidazoles / therapeutic use; Keratitis / drug therapy; Keratitis / microbiology; Keratitis / veterinary; Male; Microbial Sensitivity Tests
topics (OpenAlex): Antifungal resistance and susceptibility; Ocular Infections and Treatments; Plant Pathogens and Fungal Diseases
TL;DR: Luliconazole exhibited increased growth inhibition against both Aspergillus and Fusarium compared to commonly used, standard antifungal drugs, and warrants further investigation for its potential as an antIFungal drug for equine fungal keratitis. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: ORCID, Crossref, NC State University Libraries
Added: May 17, 2020

2020 journal article

Intrastromal Gene Therapy Prevents and Reverses Advanced Corneal Clouding in a Canine Model of Mucopolysaccharidosis I

MOLECULAR THERAPY, 28(6), 1455–1463.

By: K. Miyadera*, L. Conatser*, T. Llanga*, K. Carlin*, P. O'Donnell*, J. Bagel*, L. Song*, J. Kurtzberg* ...

MeSH headings : Animals; Animals, Genetically Modified; Corneal Diseases / diagnosis; Corneal Diseases / etiology; Corneal Diseases / therapy; Dependovirus / genetics; Disease Models, Animal; Dogs; Female; Fluorescent Antibody Technique; Gene Expression; Gene Knockdown Techniques; Gene Transfer Techniques; Genes, Reporter; Genetic Therapy / methods; Genetic Vectors / administration & dosage; Genetic Vectors / genetics; Iduronidase / genetics; Male; Mucopolysaccharidosis I / complications; Mucopolysaccharidosis I / genetics; Transgenes; Treatment Outcome
topics (OpenAlex): Lysosomal Storage Disorders Research; Virus-based gene therapy research; Adenosine and Purinergic Signaling
TL;DR: Results suggest that intrastromal AAV8G9-IDUA therapy prevents and reverses visual impairment associated with MPS I corneal clouding. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 29, 2020

2020 journal article

Ocular Tolerability and Immune Response to Corneal Intrastromal AAV-IDUA Gene Therapy in New Zealand White Rabbits

Molecular Therapy - Methods & Clinical Development, 18, 24–32.

By: L. Song*, J. Bower*, T. Llanga*, J. Salmon n, M. Hirsch* & B. Gilger n

topics (OpenAlex): Virus-based gene therapy research; Retinal Development and Disorders; Herpesvirus Infections and Treatments
TL;DR: It is suggested that AAV-opt-IDUA corneal gene therapy following corneAL intrastromal injection of AAV, shown to be effective in mucopolysaccharidosis type I (MPS I) dogs, has the potential to prevent and reverse blindness in MPS I patients in a safe and effective manner. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: September 28, 2020

2020 chapter

Ocular diseases of the Order Perissodactyla: Wild horses, Zebras, Tapirs, Rhinoceros

In K. N. Gelatt (Ed.), Veterinary Ophthalmology (6th edition). Hoboken, NJ: Wiley-Blackwell.

By: B. Gilger & A. Matthews

Ed(s): K. Gelatt

Source: NC State University Libraries
Added: October 20, 2020

2020 journal article

Optimizing corneal riboflavin administration in ex vivo horse, dog, rabbit, and pig samples for use in corneal collagen cross‐linking

Veterinary Ophthalmology, 23(5), 840–848.

By: A. Zibura n, M. Cullen n, H. Rutledge n, L. Lassalle n, J. Salmon n, B. Gilger n, H. Westermeyer n

author keywords: cornea; cross-linking; equine; iontophoresis; PCI needles; riboflavin
MeSH headings : Animals; Collagen / drug effects; Cornea / drug effects; Dogs; Horses; Injections / veterinary; Iontophoresis / veterinary; Ophthalmic Solutions / administration & dosage; Ophthalmic Solutions / pharmacology; Photosensitizing Agents / administration & dosage; Photosensitizing Agents / pharmacology; Rabbits; Riboflavin / administration & dosage; Riboflavin / pharmacology; Species Specificity; Swine
topics (OpenAlex): Corneal surgery and disorders; Corneal Surgery and Treatments; Glaucoma and retinal disorders
TL;DR: Both iontophoresis and injection via PCI needles provide efficient and effective means of riboflavin administration in ex vivo horse, dog, rabbit, and pig corneas. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: July 24, 2020

2020 journal article

Polymer-mediated delivery of vaccines to treat opioid use disorders and to reduce opioid-induced toxicity

VACCINE, 38(30), 4704–4712.

By: V. Gradinati*, F. Baruffaldi*, S. Abbaraju, M. Laudenbach*, R. Amin, B. Gilger n, P. Velagaleti, M. Pravetoni*

author keywords: Opioid; Vaccine; Polymer; Formulation; Antibody; Adjuvant
MeSH headings : Analgesics, Opioid / toxicity; Animals; Mice; Opioid-Related Disorders / drug therapy; Oxycodone / therapeutic use; Polymers; Rats; Vaccines / therapeutic use
topics (OpenAlex): Opioid Use Disorder Treatment; Intramuscular injections and effects; Neuropeptides and Animal Physiology
TL;DR: Polymer-based delivery of the anti-oxycodone vaccine was equally or more effective than administration in aluminum adjuvant in generating oxycodone-specific antibodies and in reducing oxy codone-induced effects and oxyCodone distribution to the brain in mice and rats. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 29, 2020

2020 journal article

Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles

Nature Communications, 11(1), 694.

By: H. Tsujinaka*, J. Fu*, J. Shen*, Y. Yu*, Z. Hafiz*, J. Kays*, D. McKenzie*, D. Cardona* ...

MeSH headings : Animals; Choroidal Neovascularization / drug therapy; Choroidal Neovascularization / genetics; Choroidal Neovascularization / metabolism; Female; Humans; Male; Mice; Mice, Inbred C57BL; Rabbits; Receptors, Vascular Endothelial Growth Factor / antagonists & inhibitors; Receptors, Vascular Endothelial Growth Factor / genetics; Receptors, Vascular Endothelial Growth Factor / metabolism; Retinal Diseases / drug therapy; Retinal Diseases / genetics; Retinal Diseases / metabolism; Sunitinib / administration & dosage; Sunitinib / chemistry; Sunitinib / pharmacokinetics; Swine; Swine, Miniature; Vascular Endothelial Growth Factor A / genetics; Vascular Endothelial Growth Factor A / metabolism
topics (OpenAlex): Retinal Diseases and Treatments; Retinal Imaging and Analysis; Retinal Development and Disorders
TL;DR: A microparticle-loaded tyrosine kinase inhibitor therapy is developed, which is effective for six months after a single injection in preclinical models, and provides a promising approach to achieve sustained suppression of VEGF signaling and improve outcomes in patients with retinal vascular diseases. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: October 20, 2020

2019 journal article

A Transient Developmental Background Finding in the Retina Observed in Neonatal Dogs in Juvenile Toxicology Studies

Toxicologic Pathology, 47(4), 528–541.

By: J. Petruska*, A. Remick*, T. Lejeune, M. Vezina, K. Robinson, M. Bussières, B. Gilger n, R. Dubielzig

author keywords: retina; neonatal dog; juvenile dog; juvenile toxicology; beagle dog; ocular development
MeSH headings : Age Factors; Animals; Animals, Newborn; Dogs; Fluorescein Angiography; Microscopy; Microscopy, Electron, Transmission; Retina / diagnostic imaging; Retina / growth & development; Tomography, Optical Coherence; Toxicology / methods; Vacuoles / physiology
topics (OpenAlex): Retinal Development and Disorders; Retinopathy of Prematurity Studies; Retinal Diseases and Treatments
TL;DR: In a juvenile toxicology program, an unexpected finding of vacuolation of inner nuclear, ganglion cell, and nerve fiber layers of the retina was observed microscopically in routine Davidson's fixed and hematoxylin and eosin–stained tissue sections of eyes in beagle dogs at approximately 5 weeks of age. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: July 22, 2019

2019 journal article

AAV-mediated expression of HLA-G1/5 reduces severity of experimental autoimmune uveitis

Scientific Reports, 9(1), 19864.

By: E. Crabtree n, L. Song*, T. Llanga*, J. Bower*, M. Cullen n, J. Salmon n, M. Hirsch*, B. Gilger n

MeSH headings : Animals; Antibodies, Neutralizing / metabolism; Dependovirus / genetics; Female; Genetic Therapy; HLA-G Antigens / genetics; HLA-G Antigens / metabolism; HLA-G Antigens / physiology; Intravitreal Injections; Rats; Uveitis / genetics; Uveitis / metabolism; Uveitis / pathology; Uveitis / therapy
topics (OpenAlex): Immunotherapy and Immune Responses; Herpesvirus Infections and Treatments; Reproductive System and Pregnancy
Sources: Web Of Science, NC State University Libraries, Crossref
Added: February 10, 2020

2019 journal article

Evaluation of equine corneal disease using spectral domain optical coherence tomography (SD-OCT)

Veterinary Ophthalmology, 2.

By: A. Blanchard n, E. Barr n & B. Gilger n

author keywords: cornea; equine; keratitis; optical coherence tomography
MeSH headings : Animals; Corneal Diseases / diagnosis; Corneal Diseases / pathology; Corneal Diseases / veterinary; Female; Horse Diseases / diagnosis; Horse Diseases / pathology; Horses; Male; Retrospective Studies; Tomography, Optical Coherence / methods; Tomography, Optical Coherence / veterinary
topics (OpenAlex): Optical Coherence Tomography Applications; Corneal surgery and disorders; Ocular Infections and Treatments
TL;DR: Results from this retrospective study suggest that handheld SD-OCT for imaging the cornea of horses is feasible and may be helpful in determining depth and extent of lesions in the Cornea. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 9, 2019

2019 journal article

Multi-locus DNA sequence analysis, antifungal agent susceptibility, and fungal keratitis outcome in horses from Southeastern United States

PLOS ONE, 14(3), e0214214.

By: M. Cullen n, M. Jacob n, V. Cornish n, I. VanderSchel n, H. Cotter n, M. Cubeta n, I. Carbone n, B. Gilger n

Ed(s): O. Kniemeyer

MeSH headings : Animals; Antifungal Agents / pharmacology; Eye Infections, Fungal / drug therapy; Eye Infections, Fungal / microbiology; Eye Infections, Fungal / veterinary; Horse Diseases / drug therapy; Horse Diseases / microbiology; Horses; Keratitis / drug therapy; Keratitis / microbiology; Keratitis / veterinary; Southeastern United States; Species Specificity; Thiabendazole / pharmacology
topics (OpenAlex): Ocular Infections and Treatments; Antifungal resistance and susceptibility; Plant Pathogens and Fungal Diseases
TL;DR: The results of this study suggest that treatment of equine FK with antifungal agents requires accurate fungal species identification, and demonstrate the importance of fungal identification to the species rather than genus level. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: April 15, 2019

2019 chapter

Ocular diseases of the Order Perissodactyla: Wild horses, Zebras, Tapirs, Rhinoceros

In G. Schlomo (Ed.), Exotic Animal Ophthalmology.

By: B. Gilger & A. Matthews

Ed(s): G. Schlomo

Source: NC State University Libraries
Added: February 2, 2024

2019 journal article

Subconjunctival bone marrow‐derived mesenchymal stem cell therapy as a novel treatment alternative for equine immune‐mediated keratitis: A case series

Veterinary Ophthalmology, 22(5), 674–682.

By: A. Davis n, L. Schnabel n & B. Gilger n

author keywords: bone marrow-derived mesenchymal stem cells; cornea; equine; immune-mediated keratitis; immunomodulating therapy; subconjunctival therapy
MeSH headings : Animals; Female; Horse Diseases / therapy; Horses; Keratitis / therapy; Keratitis / veterinary; Male; Mesenchymal Stem Cell Transplantation / veterinary; Treatment Outcome
topics (OpenAlex): Corneal Surgery and Treatments; Mesenchymal stem cell research; Wound Healing and Treatments
TL;DR: Experimental results demonstrate the safety and potential efficacy of an innovative solution for IMMK and show that bone marrow-derived mesenchymal stem cells have the potential to modulate the immune system by downregulating inflammation. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 9, 2019

2018 article

Association of acute leptospirosis with systemic disease and uveitis in horses

Gilger, B. C. (2018, March). EQUINE VETERINARY EDUCATION, Vol. 30, pp. 137–138.

By: B. Gilger n

topics (OpenAlex): Leptospirosis research and findings; Viral Infections and Vectors; Dermatological diseases and infestations
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2018 journal article

Factors associated with postoperative complications in healthy horses after general anesthesia for ophthalmic versus non-ophthalmic procedures: 556 cases (2012–2014)

Journal of the American Veterinary Medical Association, 252(9), 1113–1119.

By: E. Curto, E. Griffith*, L. Posner*, K. Walsh, J. Balko* & B. Gilger*

MeSH headings : Anesthesia Recovery Period; Anesthesia, General / veterinary; Animals; Colic / veterinary; Eye Diseases / surgery; Eye Diseases / veterinary; Female; Horse Diseases / surgery; Horses; Male; Ophthalmologic Surgical Procedures / veterinary; Postoperative Complications / veterinary; Records / veterinary; Treatment Outcome
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Veterinary Equine Medical Research; Anesthesia and Pain Management
TL;DR: In healthy horses, duration of general anesthesia should be minimized to decrease the risk of postanesthetic complications, and judicious use of orally administered fluconazole is recommended. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Immune Relevant Models for Ocular Inflammatory Diseases

ILAR Journal, 2.

By: B. Gilger n

author keywords: animal models; dry eye; immune-relevant; inflammatory; naturally-occurring; ocular; uveitis
MeSH headings : Animals; Disease Models, Animal; Eye Diseases / immunology; Inflammation / immunology; Uveitis / immunology
topics (OpenAlex): Ocular Surface and Contact Lens; Ocular Infections and Treatments; Antimicrobial Peptides and Activities
TL;DR: The purpose of this review is to describe common immune-relevant models of dry eye and uveitis with an overview of the immuno-pathogenesis of each disease and reported evaluation of models from small to large animals. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 9, 2019

2018 journal article

Nonclinical Development of ENV905 (Difluprednate) Ophthalmic Implant for the Treatment of Inflammation and Pain Associated with Ocular Surgery

Journal of Ocular Pharmacology and Therapeutics, 34(1-2), 161–169.

By: R. Verhoeven, A. Garcia, R. Robeson, B. Gilger*, D. Culp, C. Struble*, L. Hamm*, T. Navratil, B. Yerxa

author keywords: difluprednate; intracameral; corticosteroid; ENV905; subconjunctival
MeSH headings : Animals; Cataract Extraction / adverse effects; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Delivery Systems; Female; Fluprednisolone / administration & dosage; Fluprednisolone / analogs & derivatives; Fluprednisolone / chemistry; Fluprednisolone / therapeutic use; Inflammation / drug therapy; Injections, Intraocular; Ophthalmic Solutions / administration & dosage; Ophthalmic Solutions / chemistry; Ophthalmic Solutions / therapeutic use; Pain, Postoperative / drug therapy; Rabbits
topics (OpenAlex): Ocular Surface and Contact Lens; Advanced Drug Delivery Systems; Advancements in Transdermal Drug Delivery
TL;DR: ENV905 was well tolerated and demonstrated a robust reduction in ocular inflammation with targeted drug delivery, and shows that ENV905 provides a sustained therapeutic effect after a single dose. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019

2018 journal article

Serotype survey of AAV gene delivery via subconjunctival injection in mice

Gene Therapy, 25(6), 402–414.

By: L. Song*, T. Llanga*, L. Conatser*, V. Zaric*, B. Gilger n & M. Hirsch*

MeSH headings : Animals; Conjunctiva / pathology; Cornea / metabolism; Cornea / pathology; Cornea / virology; Dependovirus / genetics; Eye Diseases / genetics; Eye Diseases / pathology; Eye Diseases / therapy; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors / genetics; Genetic Vectors / immunology; Green Fluorescent Proteins / genetics; Humans; Mice; Serogroup; Surveys and Questionnaires; Transduction, Genetic
topics (OpenAlex): Virus-based gene therapy research; Herpesvirus Infections and Treatments; Retinal Development and Disorders
TL;DR: Subconjunctival administration of particular AAV serotypes may be a simple and safe targeted gene delivery route for ocular surface, muscular, corneal, and optic nerve diseases. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: October 16, 2018

2018 chapter

Spontaneous Incidence of Ocular Abnormalities in Laboratory Animals

In Standards for Ocular Toxicology and Inflammation (pp. 141–168).

By: B. Gilger*, M. Brown, R. Munger, J. Bartoe*, M. Bussieres & C. Cook*

topics (OpenAlex): Immunotoxicology and immune responses; Animal testing and alternatives; Animal Ecology and Behavior Studies
TL;DR: This chapter provides incidence data on spontaneous ophthalmic abnormalities in the most commonly used species in toxicological and pharmacokinetic drug research to improve speed of drug development, reduce the number of studies that need to be repeated, and thus reduce the overall number of animals used in toxicology research and drug development. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019

2018 chapter

Standard Operating Procedures for Common Laboratory Animal Ocular Procedures

In Standards for Ocular Toxicology and Inflammation (pp. 27–44).

By: B. Gilger n, J. Bartoe*, J. Eaton & R. Boyd*

topics (OpenAlex): Retinal Development and Disorders; Glaucoma and retinal disorders; Animal testing and alternatives
TL;DR: This chapter provides a basis for researchers, contract research laboratories, or other investigators to develop harmonized protocols for commonly performed ophthalmic procedures in laboratory animals and to assist in development of institutional standard operating procedure (SOP) documentation. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019

2018 chapter

Standards for Conducting Ophthalmic Examinations in Laboratory Animals

In Standards for Ocular Toxicology and Inflammation (pp. 1–25).

By: D. Wilkie*, B. Gilger* & J. Bartoe*

topics (OpenAlex): Retinal Development and Disorders; Glaucoma and retinal disorders; Retinal and Optic Conditions
TL;DR: The ophthalmologist must beamiliar with the wide range of species used in the field of toxicology, be familiar with the anatomic variations associated with these species, be able to differentiate an inherited or a breed-related finding from a study-related effect, be competent with the required ophthalmic equipment, and be capable of examining this widerange of animals. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019

2018 book

Standards in Ocular Toxicology and Inflammation

Cham, Switzerland: Springer.

Brian Gilger

Ed(s): B. Gilger, C. Cook & M. Brown

Source: NC State University Libraries
Added: October 20, 2020

2017 journal article

AAV vector-meditated expression of HLA-G reduces injury-induced corneal vascularization, immune cell infiltration, and fibrosis

Scientific Reports, 7(1).

By: M. Hirsch*, L. Conatser*, S. Smith n, J. Salmon n, J. Wu*, N. Buglak*, R. Davis*, B. Gilger n

MeSH headings : Animals; Corneal Injuries / genetics; Corneal Injuries / metabolism; Corneal Injuries / pathology; Corneal Injuries / therapy; Corneal Neovascularization / genetics; Corneal Neovascularization / metabolism; Corneal Neovascularization / pathology; Corneal Neovascularization / therapy; Dependovirus; Gene Expression; Genetic Therapy; HEK293 Cells; HLA-G Antigens / biosynthesis; HLA-G Antigens / genetics; Humans; Rabbits
topics (OpenAlex): Corneal Surgery and Treatments; Reproductive System and Pregnancy; Tendon Structure and Treatment
TL;DR: The collective data demonstrate the clinical potential of scAAV8G9-optHLA-G to safely and effectively treat corneal vascularization and inhibit fibrosis while alluding to broader roles in ocular surface immunity and allogenic organ transplantation. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

Advanced Imaging of the Equine Eye

Veterinary Clinics of North America: Equine Practice, 33(3), 607–626.

By: B. Gilger n

author keywords: Equine; Eye; Imaging; Ultrasound; Computed tomography; MRI; Optical coherence tomography; Confocal microscopy
MeSH headings : Animals; Eye / diagnostic imaging; Horses / anatomy & histology; Magnetic Resonance Imaging / veterinary; Tomography, Optical Coherence / veterinary; Tomography, X-Ray Computed / veterinary; Ultrasonography / veterinary
topics (OpenAlex): Ocular Infections and Treatments; Ocular Surface and Contact Lens; Optical Coherence Tomography Applications
TL;DR: The literature for studies describing advanced imaging of the equine eye as a reference for practitioners to help in the selection of image modalities, describe how to use the instruments, and help interpret the image findings are reviewed. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: January 24, 2020

2017 journal article

Effect of bone marrow-derived mesenchymal stem cells and stem cell supernatant on equine corneal wound healing in vitro

Stem Cell Research & Therapy, 8(1).

By: A. Sherman n, B. Gilger n, A. Berglund n & L. Schnabel n

author keywords: Mesenchymal stem cells; Equine; Corneal wound healing; Corneal stromal cells/fibroblasts; Scratch assay; TGF-beta 1
MeSH headings : Animals; Biomarkers / metabolism; Bone Marrow Cells / cytology; Corneal Injuries / pathology; Corneal Injuries / therapy; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor / metabolism; Female; Flow Cytometry; Horses; Male; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Transforming Growth Factor beta1 / metabolism; Wound Healing
topics (OpenAlex): Mesenchymal stem cell research; Corneal Surgery and Treatments; Periodontal Regeneration and Treatments
TL;DR: The significant decrease in scratch area in equine corneal fibroblast cultures treated with autologous BM-MSCs compared to MSC-Sp or control treatments suggests that BM- MSCs may substantially improve corNEal wound healing in horses. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2017 book

Equine Ophthalmology

(3rd ed.). Ames, IA: Wiley Blackwell.

Brian Gilger

Ed(s): B. Gilger

Source: NC State University Libraries
Added: October 19, 2020

2017 journal article

Evaluation of Intracameral Pentablock Copolymer Thermosensitive Gel for Sustained Drug Delivery to the Anterior Chamber of the Eye

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, 33(5), 353–360.

By: E. Schaefer n, S. Smith n, J. Salmon n, S. Abbaraju*, R. Amin*, S. Weiss, U. Grau, P. Velagaleti, B. Gilger n

author keywords: ocular; sustained drug delivery; intracameral; pentablock; copolymer
MeSH headings : Animals; Anterior Chamber / drug effects; Anterior Chamber / metabolism; Drug Delivery Systems; Drug Tolerance; Gels / administration & dosage; Gels / pharmacokinetics; Injections, Intraocular; Polymers / administration & dosage; Polymers / pharmacokinetics; Rabbits; Temperature
topics (OpenAlex): Advanced Drug Delivery Systems; Ocular Surface and Contact Lens; Corneal Surgery and Treatments
TL;DR: The results demonstrate the potential of intracameral PTSgel formulations for sustained delivery of biologic therapies to the ocular anterior segment and drug release profile, tolerability, and polymer degradation for one of the thermosensitive, biodegradable, and biocompatible compositions were investigated through intracAMeral injection in rabbits. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Evaluation of pentablock co-polymer (PTS sol ) for sustained topical ocular drug delivery

Journal of Drug Delivery Science and Technology, 39, 475–483.

By: S. Smith n, S. Abbaraju*, J. Salmon n, R. Amin*, S. Weiss, U. Grau, P. Velagaleti, B. Gilger n

author keywords: Ocular; Sustained drug delivery; Pentablock co-polymers; Hydrophobic drugs; Brinzolamide; Hydrophilic drugs
topics (OpenAlex): Advanced Drug Delivery Systems; Ocular Surface and Contact Lens; Advancements in Transdermal Drug Delivery
TL;DR: Ocular retention, tolerability, and sustained pharmacodynamics of a clear topical formulation of brinzolamide (BRZ) in PTS sol pentablock co-polymer suggest that drugs in PTSsol may allow for once a day or less frequent dosing. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

Optic neuritis in dogs: 96 cases (1983-2016)

Veterinary Ophthalmology, 21(5), 442–451.

By: S. Smith n, H. Westermeyer n, C. Mariani n, B. Gilger n & M. Davidson n

author keywords: causes of canine optic neuritis; dogs; granulomatous meningoencephalitis; meningoencephalitis of unknown etiology; ocular GME; optic neuritis
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / epidemiology; Dog Diseases / etiology; Dog Diseases / therapy; Dogs; Female; Magnetic Resonance Imaging; Male; Medical Records; Meningoencephalitis / complications; Meningoencephalitis / veterinary; North Carolina / epidemiology; Optic Neuritis / epidemiology; Optic Neuritis / veterinary
topics (OpenAlex): Veterinary Oncology Research; Herpesvirus Infections and Treatments; Rabies epidemiology and control
TL;DR: Optic neuritis was most commonly associated with multifocal MUE or was isolated as the sole neurologic finding, with a similar incidence between the two groups. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: November 12, 2018

2017 chapter

Uveal diseases

In B. C. Gilger (Ed.), Equine Ophthalmology (3rd ed.). Ames, IA: Wiley Blackwell.

By: B. Gilger

Ed(s): B. Gilger

Source: NC State University Libraries
Added: October 19, 2020

2016 journal article

544. Comparison of AAV Serotype2 Transduction by Various Delivery Routes to the Mouse Eye

Molecular Therapy, 24, S217–S218.

By: K. Woodard*, M. Vance*, B. Gilger*, R. Samulski* & M. Hirsch*

topics (OpenAlex): Virus-based gene therapy research; Herpesvirus Infections and Treatments; Cytomegalovirus and herpesvirus research
TL;DR: The transduction of multiple retinal layers throughout the retina without the damage of retinal detachment and widespread distribution makes suprachoroidal injections a better delivery route than to subretinal injection. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 24, 2020

2016 journal article

AAV Gene Therapy for MPS1-associated Corneal Blindness

Scientific Reports, 6(1).

By: M. Vance*, T. Llanga*, W. Bennett*, K. Woodard*, G. Murlidharan*, N. Chungfat*, A. Asokan*, B. Gilger* ...

MeSH headings : Apoptosis / genetics; Blindness / enzymology; Blindness / genetics; Blindness / therapy; Blotting, Western; Cells, Cultured; Cornea / metabolism; Cornea / pathology; Corneal Diseases / enzymology; Corneal Diseases / genetics; Corneal Diseases / therapy; Dependovirus / genetics; Fibroblasts / cytology; Fibroblasts / metabolism; Genetic Therapy / methods; Genetic Vectors / genetics; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; HEK293 Cells; Humans; Iduronidase / genetics; Iduronidase / metabolism; Microscopy, Confocal; Mucopolysaccharidosis I / enzymology; Mucopolysaccharidosis I / genetics; Mucopolysaccharidosis I / therapy; Organ Culture Techniques; Transfection / methods
topics (OpenAlex): Virus-based gene therapy research; Cytomegalovirus and herpesvirus research; Retinal Development and Disorders
TL;DR: The collective preclinical data demonstrate safe and efficient IDUA delivery to human corneas, which may prevent and potentially reverse MPS1-associated cornea blindness. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019

2016 journal article

Best practice recommendations for prehospital veterinary care of dogs and cats

Journal of Veterinary Emergency and Critical Care, 26(2), 166–233.

By: R. Hanel n, L. Palmer, J. Baker, J. Brenner, D. Crowe, D. Dorman n, J. Gicking, B. Gilger n ...

author keywords: cat; dog; first response; trauma; VetCOT
MeSH headings : Animals; Cats; Consensus; Databases, Factual; Dogs; Emergency Service, Hospital / standards; Practice Guidelines as Topic; Practice Management, Veterinary / standards; United States; Veterinary Medicine / standards; Wounds and Injuries / therapy; Wounds and Injuries / veterinary
topics (OpenAlex): Trauma and Emergency Care Studies; Trauma, Hemostasis, Coagulopathy, Resuscitation; Cardiac Arrest and Resuscitation
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2016 journal article

Cytokine and chemokine profiles of aqueous humor and serum in horses with uveitis measured using multiplex bead immunoassay analysis

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 182, 43–51.

By: E. Curto n, K. Messenger n, J. Salmon n & B. Gilger n

author keywords: Uveitis; Multiplex; Horse; Cytokine; Chemokine; Leptospirosis
MeSH headings : Animals; Aqueous Humor / immunology; Biomarkers / blood; Biomarkers / metabolism; Chemokines / blood; Chemokines / metabolism; Cytokines / blood; Cytokines / metabolism; Horse Diseases / blood; Horse Diseases / diagnosis; Horse Diseases / immunology; Horses; Immunoassay; Inflammation Mediators / blood; Inflammation Mediators / metabolism; Leptospirosis / blood; Leptospirosis / immunology; Leptospirosis / veterinary; Uveitis / blood; Uveitis / immunology; Uveitis / veterinary
topics (OpenAlex): Leptospirosis research and findings; Mycobacterium research and diagnosis
TL;DR: The anti-inflammatory cytokine IL-10 and the pro- inflammatory cytokine IP-10 appear to play an important role in ERU. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 book

Equine Ophthalmology

Brian Gilger

Ed(s): B. Gilger

topics (OpenAlex): Intraocular Surgery and Lenses
TL;DR: This review is intended to describe briefly some of the medications, techniques, and devices currently employed in equine ophthalmology that will provide a foundation for the sound management of ocular disease. (via Semantic Scholar)
Source: ORCID
Added: September 9, 2019

2016 chapter

Equine ocular examination basic techniques

In B. Gilger (Ed.), Equine Ophthalmology (pp. 1–39).

By: R. Stoppini & B. Gilger*

Ed(s): B. Gilger*

topics (OpenAlex): Veterinary Equine Medical Research; Ocular Infections and Treatments; Entomological Studies and Ecology
Sources: Crossref, NC State University Libraries
Added: January 29, 2024

2016 journal article

Histiocytic chorioretinitis in a dog

Veterinary Ophthalmology, 21(1), 88–95.

By: A. Sherman n, J. Cullen n, H. Westermeyer n, C. Grindem n & B. Gilger n

author keywords: canine; chorioretinitis; histiocytic; Melan-A; melanoma; retinal detachment
MeSH headings : Animals; Chorioretinitis / diagnosis; Chorioretinitis / veterinary; Diagnosis, Differential; Diagnostic Techniques, Ophthalmological; Dog Diseases / diagnosis; Dogs; Eye Enucleation; Male
topics (OpenAlex): Ocular Oncology and Treatments; Veterinary Oncology Research; Corneal Surgery and Treatments
TL;DR: A 3-year-old castrated male mixed-breed dog presented with an acute bullous retinal detachment and thickened choroid of the right eye, which caused a revision of the histologic diagnosis from melanocytic tumor to histiocytic chorioretinitis. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

Impact of fungal species cultured on outcome in horses with fungal keratitis

Veterinary Ophthalmology, 20(2), 140–146.

By: A. Sherman n, A. Clode n & B. Gilger n

author keywords: Aspergillus spp.; cornea; equine; fungal culture; Fusarium spp.; keratomycosis
MeSH headings : Animals; Antifungal Agents / therapeutic use; Aspergillosis / drug therapy; Aspergillosis / veterinary; Aspergillus; Eye Infections, Bacterial / drug therapy; Eye Infections, Bacterial / veterinary; Eye Infections, Fungal / drug therapy; Eye Infections, Fungal / microbiology; Eye Infections, Fungal / veterinary; Female; Fusariosis / drug therapy; Fusariosis / veterinary; Fusarium; Horse Diseases / drug therapy; Horse Diseases / microbiology; Horses; Keratitis / drug therapy; Keratitis / microbiology; Keratitis / veterinary; Male; Retrospective Studies; Steroids / therapeutic use; Treatment Outcome
topics (OpenAlex): Ocular Infections and Treatments; Ocular Surface and Contact Lens; Corneal Surgery and Treatments
TL;DR: Genus of fungus cultured was not significantly associated with the need for surgical intervention nor was it significantlyassociated with the necessity of globe-sparing surgery versus enucleation, and bacterial co-infection, previous topical steroidal or antifungal use, and time of year did not affect outcome or type of fungal species cultured. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2016 journal article

Prognosis and impact of equine recurrent uveitis

Equine Veterinary Journal, 48(3), 290–298.

By: J. Gerding n & B. Gilger n

author keywords: horse; recurrent; uveitis; retrospective; outcome; leptospirosis
MeSH headings : Animals; Female; Horse Diseases / epidemiology; Horse Diseases / pathology; Horse Diseases / therapy; Horses; Male; Retrospective Studies; Risk Factors; Southeastern United States; Uveitis / epidemiology; Uveitis / pathology; Uveitis / therapy; Uveitis / veterinary
topics (OpenAlex): Leptospirosis research and findings; Mycobacterium research and diagnosis; T-cell and Retrovirus Studies
TL;DR: The impact of ERU is attributed to the high frequency of blindness, globe loss and loss of function, along with financial costs of the disease, which have a significant impact on affected horses and their owners. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 chapter

Recurrent uveitis

In M. J. B. Felippe (Ed.), Equine Clinical Immunology. Ames, Iowa: Wiley Blackwell.

By: B. Gilger

Ed(s): M. Felippe

Source: NC State University Libraries
Added: October 19, 2020

2016 journal article

Sustained Release of Protein Therapeutics from Subcutaneous Thermosensitive Biocompatible and Biodegradable Pentablock Copolymers (PTSgels)

JOURNAL OF DRUG DELIVERY, 2016.

By: E. Schaefer n, S. Abbaraju*, M. Walsh n, D. Newman n, J. Salmon n, R. Amin*, S. Weiss, U. Grau ...

topics (OpenAlex): Advanced Drug Delivery Systems; Botulinum Toxin and Related Neurological Disorders; Intramuscular injections and effects
TL;DR: Subcutaneous PTSgels were highly biocompatible and in vitro IgG release occurred in parallel with the disappearance of subcutaneous gel in vivo, and modulation of release of biologics to fit the therapeutic need can be achieved by varying the biocombatible and biodegradable PTSgel composition. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 article

Topical delivery of aqueous micellar Resolvin E1 analog (RX-10045) (vol 498, pg 326, 2016)

Cholkar, K., Gilger, B. C., & Mitra, A. K. (2016, July 25). INTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol. 509, pp. 528–528.

By: K. Cholkar*, B. Gilger n & A. Mitra*

topics (OpenAlex): Advanced Polymer Synthesis and Characterization
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Topical delivery of aqueous micellar resolvin E1 analog (RX-10045)

International Journal of Pharmaceutics, 498(1-2), 326–334.

By: K. Cholkar*, B. Gilger n & A. Mitra*

author keywords: Aqueous; Formulation; Micelles; Resolving; Inflammation; Sclera; Drug delivery; Back-of-the-eye; Posterior; Topical; Eye drop; Retina/choroid; Rabbits
MeSH headings : Administration, Ophthalmic; Administration, Topical; Animals; Drug Delivery Systems / methods; Eicosapentaenoic Acid / administration & dosage; Eicosapentaenoic Acid / analogs & derivatives; Eicosapentaenoic Acid / chemistry; Eicosapentaenoic Acid / metabolism; Female; Micelles; Rabbits; Solubility; Tissue Distribution / drug effects; Tissue Distribution / physiology; Vitreous Body / drug effects; Vitreous Body / metabolism; Water / chemistry
topics (OpenAlex): Ocular Surface and Contact Lens; Retinoids in leukemia and cellular processes; Advancements in Transdermal Drug Delivery
TL;DR: Micelles appear to follow conjunctival/scleral pathway to reach back-of-the-eye tissue (retina) and topical aqueous formulations may be employed to treat posterior ocular diseases. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2015 journal article

Causes of endogenous uveitis in cats presented to referral clinics in North Carolina

Veterinary Ophthalmology, 19, 30–37.

By: M. Jinks, R. English* & B. Gilger*

author keywords: causes; endogenous uveitis; feline uveitis; prevalence
MeSH headings : Animals; Cat Diseases / epidemiology; Cat Diseases / etiology; Cat Diseases / microbiology; Cat Diseases / virology; Cats; Female; Male; Neoplasms / complications; Neoplasms / veterinary; North Carolina / epidemiology; Uveitis / etiology; Uveitis / microbiology; Uveitis / veterinary; Uveitis / virology
topics (OpenAlex): Bartonella species infections research; Viral Infections and Vectors; Herpesvirus Infections and Treatments
TL;DR: Because of the high prevalence of FIP, young cats with uveitis should be evaluated for hyperglobulinemia and FCoV serology should be performed as minimal diagnostics. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

Clinical, histopathological and immunohistochemical characterization of a novel equine ocular disorder: heterochromic iridocyclitis with secondary keratitis in adult horses

VETERINARY OPHTHALMOLOGY, 18(6), 443–456.

By: N. Pinto n, R. McMullen n, K. Linder n, J. Cullen n & B. Gilger n

author keywords: endotheliitis; iridocyclitis; keratic precipitates; keratitis; retrocorneal membrane; uveitis
MeSH headings : Animals; Cornea / pathology; Female; Horse Diseases / diagnosis; Horse Diseases / pathology; Horses; Iridocyclitis / diagnosis; Iridocyclitis / pathology; Iridocyclitis / veterinary; Keratitis / diagnosis; Keratitis / pathology; Keratitis / veterinary; Male; Uvea / pathology
topics (OpenAlex): Ocular Infections and Treatments; Natural product bioactivities and synthesis
TL;DR: Heterochromic iridocyclitis with secondary keratitis (HIK) is characterized by uveal inflammation with pigment dispersion and suspected corneal endothelial dysfunction and may not respond to therapy and enucleation may ultimately be required to ensure the horse's comfort. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Equine eosinophilic keratitis in horses: 28 cases (2003-2013)

Clinical Case Reports, 3(12), 1000–1006.

By: S. Edwards*, A. Clode n & B. Gilger n

author keywords: Eosinophilic conjunctivitis; eosinophilic keratitis; eosinophilic keratoconjuctivitis; equine
topics (OpenAlex): Eosinophilic Esophagitis; Eosinophilic Disorders and Syndromes; Food Allergy and Anaphylaxis Research
TL;DR: This retrospective case series evaluates husbandry and environmental conditions in relation to eosinophilic keratitis in horses to identify an increased prevalence of presentation in summer months. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 24, 2020

2015 chapter

Ocular Trauma

In E. Robinson & K. Sprayberry (Eds.), Robinson's Current Therapy in Equine Medicine (Vol. 7, pp. 39–44).

By: B. Gilger*

Ed(s): E. Robinson & K. Sprayberry

topics (OpenAlex): Traumatic Ocular and Foreign Body Injuries; Facial Trauma and Fracture Management; Intraocular Surgery and Lenses
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: September 9, 2019

2015 journal article

Phacoemulsification and aspiration for cataract management in a dollar sunfish,Lepomis marginatus(Holbrook) - a case report

Journal of Fish Diseases, 38(12), 1089–1092.

By: L. Adamovicz n, G. Lewbart n & B. Gilger n

author keywords: cataract; dollar sunfish; extracapsular lens extraction; Lepomis marginatus; phacoemulsification
MeSH headings : Animals; Cataract / therapy; Cataract / veterinary; Fish Diseases / therapy; Male; Perciformes; Phacoemulsification / methods; Phacoemulsification / veterinary; Suction / methods; Suction / veterinary
topics (OpenAlex): Cassava research and cyanide; Identification and Quantification in Food; Connexins and lens biology
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

Presumed primary ocular lymphangiosarcoma with metastasis in a miniature horse

Veterinary Ophthalmology, 18(6), 502–509.

By: J. Gerding n, B. Gilger n, S. Montgomery* & A. Clode n

author keywords: histopathology; horse; immunohistochemistry; lymphangiosarcoma; metastatic; ocular
MeSH headings : Animals; Corneal Diseases / diagnosis; Corneal Diseases / pathology; Corneal Diseases / therapy; Corneal Diseases / veterinary; Eye Neoplasms / diagnosis; Eye Neoplasms / pathology; Eye Neoplasms / therapy; Eye Neoplasms / veterinary; Fatal Outcome; Female; Horse Diseases / diagnosis; Horse Diseases / pathology; Horses; Lymphangiosarcoma / diagnosis; Lymphangiosarcoma / pathology; Lymphangiosarcoma / therapy; Lymphangiosarcoma / veterinary
topics (OpenAlex): Vascular Tumors and Angiosarcomas; Veterinary Oncology Research; Lymphatic System and Diseases
TL;DR: A 7-year-old, 153.0-kg American Miniature mare presented for evaluation of keratoconjunctivitis of the right eye (OD), and a primary ocular lymphangiosarcoma with metastasis was diagnosed. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2015 other

Recurrent Uveitis

By: B. Gilger n

topics (OpenAlex): Leptospirosis research and findings; Mycobacterium research and diagnosis; Vector-borne infectious diseases
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: NC State University Libraries, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

Retrobulbar pigmented peripheral nerve sheath tumor in a dog

Veterinary Ophthalmology, 19(6), 518–524.

By: E. Curto n, A. Clode*, J. Durrant n, K. Montgomery & B. Gilger n

author keywords: exophthalmos; peripheral nerve sheath tumor; pigmented; pug; retrobulbar; sarcoma
MeSH headings : Animals; Dog Diseases / pathology; Dogs; Exophthalmos; Male; Nerve Sheath Neoplasms / pathology; Nerve Sheath Neoplasms / veterinary; Orbit; Quality of Life; Tomography, X-Ray Computed
topics (OpenAlex): Neurofibromatosis and Schwannoma Cases; Head and Neck Surgical Oncology; Veterinary Oncology Research
TL;DR: A 1-year-old male castrated Pug was referred for unilateral exophthalmos unresponsive to oral antibiotic and anti-inflammatory therapy; the patient was euthanized 13 weeks following exenteration due to development of neurologic signs and perceived poor quality of life. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

Topical, Aqueous, Clear Cyclosporine Formulation Design for Anterior and Posterior Ocular Delivery

Translational Vision Science & Technology, 4(3), 1.

By: K. Cholkar*, B. Gilger n & A. Mitra*

author keywords: nanomicelles; formulation; cyclosporine; sclera; drug delivery; drops; back of the eye; posterior; topical; retina/choroid; rabbits; dry eye
topics (OpenAlex): Advanced Drug Delivery Systems; Ocular Surface and Contact Lens; Corneal Surgery and Treatments
TL;DR: Results suggest that aqueous nanomicellar approach can provide high corneal and conjunctival CsA concentrations and suggest polymeric blend to be a safe carrier for anterior and posterior ocular tissues. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2014 journal article

Efficacy of cox-2 inhibitors in controlling inflammation and capsular opacification after phacoemulsification cataract removal

Veterinary Ophthalmology, 18(3), 175–185.

By: H. Brookshire*, R. English*, B. Nadelstein*, A. Weigt*, B. Gift* & B. Gilger n

author keywords: Bromfenac; celecoxib; intraocular lens implant; posterior capsule opacification; phacoemulsification; prednisolone acetate
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Benzophenones / therapeutic use; Bromobenzenes / therapeutic use; Celecoxib / administration & dosage; Celecoxib / therapeutic use; Cyclooxygenase 2 Inhibitors / administration & dosage; Cyclooxygenase 2 Inhibitors / therapeutic use; Dog Diseases / therapy; Dogs; Inflammation / prevention & control; Inflammation / veterinary; Intraocular Pressure; Lenses, Intraocular / veterinary; Phacoemulsification / adverse effects; Phacoemulsification / veterinary; Prednisolone / administration & dosage; Prednisolone / analogs & derivatives; Prednisolone / therapeutic use
topics (OpenAlex): Intraocular Surgery and Lenses; Ocular Infections and Treatments; Glaucoma and retinal disorders
TL;DR: Eyes receiving celecoxib-IOL/PA had better initial control of inflammation and bromfenac had better long-term control of PCO, and there was no association between COX-2 inhibitor administration and ocular hypertension. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Episcleral, Intrascleral, and Suprachoroidal Routes of Ocular Drug Delivery - Recent Research Advances and Patents

Recent Patents on Drug Delivery & Formulation, 8(2), 81–91.

By: B. Gilger*, A. Mandal, S. Shah & A. Mitra n

topics (OpenAlex): Advanced Drug Delivery Systems; Nanoparticle-Based Drug Delivery; Supramolecular Self-Assembly in Materials
TL;DR: This manuscript will review the recent research advances and patents on episcleral, intrasCleral, and suprachoroidal routes of ocular drug delivery. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 15, 2024

2014 journal article

Episcleral, intrascleral, and suprachoroidal routes of ocular drug delivery – Recent research advances and patents

Recent Patents on Drug Delivery and Formulation.

By: B. Gilger, A. Mandal, S. Shah & A. Mitra

topics (OpenAlex):
Sources: NC State University Libraries, NC State University Libraries
Added: December 16, 2019

2014 review

Equine orbital fractures: a review of 18 cases (2006-2013)

[Review of ]. VETERINARY OPHTHALMOLOGY, 17, 97–106.

By: J. Gerding n, A. Clode n, B. Gilger n & K. Montgomery n

author keywords: Complication; equine; fracture; orbital; outcome; retrospective
MeSH headings : Animals; Female; Horses / injuries; Male; Orbital Fractures / complications; Orbital Fractures / diagnostic imaging; Orbital Fractures / etiology; Orbital Fractures / therapy; Orbital Fractures / veterinary; Retrospective Studies; Tomography, X-Ray Computed / veterinary; Zygomatic Fractures / complications; Zygomatic Fractures / diagnostic imaging; Zygomatic Fractures / etiology; Zygomatic Fractures / therapy; Zygomatic Fractures / veterinary
topics (OpenAlex): Veterinary Equine Medical Research; Sports injuries and prevention; Veterinary Pharmacology and Anesthesia
TL;DR: Horses sustaining orbital fractures treated promptly with medical and surgical therapy have a favorable prognosis for return to function and cosmesis and warrant more aggressive therapy and decrease functional and cosmetic outcome. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Modified lamellar keratoplasties for the treatment of deep stromal abscesses in horses

Veterinary Ophthalmology, 18(5), 393–403.

By: R. McMullen n, B. Gilger n & T. Michau

author keywords: deep lamellar endothelial keratoplasty; deep stromal abscess; equine ophthalmology; posterior lamellar keratoplasty; sedation; standing surgery
MeSH headings : Abscess / surgery; Abscess / veterinary; Animals; Corneal Diseases / surgery; Corneal Diseases / veterinary; Corneal Stroma / surgery; Corneal Transplantation / methods; Corneal Transplantation / veterinary; Female; Horse Diseases / surgery; Horses / surgery; Male
topics (OpenAlex): Veterinary Equine Medical Research; Veterinary Pharmacology and Anesthesia; Ocular Infections and Treatments
TL;DR: In horses with deep stromal or endothelial abscesses, for which general anesthesia is not an option, both the modified DLEK and PLK corneal procedures may be performed as an alternative to enucleation on the standing, sedated horse. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2014 book

Ocular Pharmacology and Toxicology

In Methods in Pharmacology and Toxicology.

Brian Gilger

Ed(s): B. Gilger n

topics (OpenAlex): Drug-Induced Ocular Toxicity; Glaucoma and retinal disorders
Source: Crossref
Added: March 11, 2025

2014 book

Ocular pharmacology and toxicology

New York: Humana Press/Springer.

Brian Gilger

Ed(s): B. Gilger

Source: NC State University Libraries
Added: October 19, 2020

2014 journal article

Retrospective analysis of equine cataract surgery – visual outcomes vs age, IOL, and ERU status (35 cases)

Veterinary Ophthalmology, 17, 160–167.

By: M. Edelmann n, R. McMullen n, R. Stoppini*, A. Clode n & B. Gilger n

author keywords: cataracts; chronic uveitis; equine; intraocular lens; phacoemulsification; prognosis
MeSH headings : Age Factors; Animals; Cataract / veterinary; Female; Horses; Lenses, Intraocular / veterinary; Male; Phacoemulsification / adverse effects; Phacoemulsification / veterinary; Postoperative Complications / veterinary; Retrospective Studies; Treatment Outcome; Uveitis / etiology; Uveitis / veterinary; Vision Disorders / etiology; Vision Disorders / veterinary
topics (OpenAlex): Ocular Infections and Treatments; Intraocular Surgery and Lenses; Veterinary Equine Medical Research
TL;DR: Horses with chronic uveitis had significantly less favorable visual outcome after PA, and older age at surgery and IOL use were not associated with poor visual outcome. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Spectral-domain optical coherence tomography evaluation of the cornea, retina, and optic nerve in normal horses

Veterinary Ophthalmology, 17, 140–148.

By: N. Pinto n & B. Gilger n

author keywords: SD-OCT; equine; cornea; retina; pachymetry
MeSH headings : Animals; Cornea / anatomy & histology; Feasibility Studies; Female; Horses / anatomy & histology; Male; Optic Nerve / anatomy & histology; Retina / anatomy & histology; Tomography, Optical Coherence / veterinary
topics (OpenAlex): Ocular Infections and Treatments; Corneal surgery and disorders; Intraocular Surgery and Lenses
TL;DR: The SD-OCT instrument employed in this study may be used on sedated horses and allows the acquisition of high-resolution images, and thickness measurements involving the cornea, retina, and optic nerve. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Surgical correction of lens luxation in the horse: visual outcomes

Veterinary Medicine and Animal Sciences, 2(1), 2.

By: D. Brooks*, B. Gilger n, C. Plummer*, C. Hartley*, D. Donaldson*, J. Lavach*, L. Karpinski

topics (OpenAlex): Intraocular Surgery and Lenses; Veterinary Equine Medical Research; Plant Toxicity and Pharmacological Properties
TL;DR: The visual outcomes of surgical therapy for lens luxation/subluxation in the horse were described and the medical records of horses that had undergone surgery were obtained. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2014 journal article

Use of episcleral cyclosporine implants in dogs with keratoconjunctivitis sicca

Veterinary Ophthalmology, 18(3), 234–241.

By: L. Barachetti*, A. Rampazzo*, C. Mortellaro*, S. Scevola* & B. Gilger n

author keywords: cyclosporine; dog; dry eye; implant; keratoconjunctivitis sicca; sustained release delivery
MeSH headings : Animals; Conjunctiva / drug effects; Cyclosporine / administration & dosage; Cyclosporine / therapeutic use; Dog Diseases / drug therapy; Dogs; Female; Immunosuppressive Agents / administration & dosage; Keratoconjunctivitis Sicca / drug therapy; Keratoconjunctivitis Sicca / veterinary; Male; Prostheses and Implants / veterinary; Retrospective Studies
topics (OpenAlex): Ocular Surface and Contact Lens; Corneal Surgery and Treatments; Glaucoma and retinal disorders
TL;DR: Results from this study suggest that the EMSC implants were well tolerated and efficacious in dogs with KCS responsive to topical CsA as well as dogs with poor response to topical therapy. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2014 article

Veterinary Ophthalmology - Equine Ophthalmology Special Issue Preface

Clode, A., & Gilger, B. (2014, July). VETERINARY OPHTHALMOLOGY, Vol. 17, pp. 1–1.

By: A. Clode n & B. Gilger n

MeSH headings : Animals; Eye Diseases / diagnosis; Eye Diseases / therapy; Eye Diseases / veterinary; Horse Diseases / diagnosis; Horse Diseases / therapy; Horses
topics (OpenAlex): Glaucoma and retinal disorders; Veterinary Orthopedics and Neurology
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 chapter

Challenges in Ocular Pharmacokinetics, Pharmacodynamics, and Toxicology

In Methods in Pharmacology and Toxicology (pp. 1–6).

By: B. Gilger n

topics (OpenAlex): Drug-Induced Ocular Toxicity; Ocular Infections and Treatments; Retinal Diseases and Treatments
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2013 journal article

Diode laser endoscopic cyclophotocoagulation in the normal equine eye

VETERINARY OPHTHALMOLOGY, 16(2), 97–110.

By: J. Harrington n, R. McMullen n, J. Cullen n, N. Campbell n & B. Gilger n

author keywords: diode laser; endoscopic cyclophotocoagulation; equine; glaucoma; histopathology
MeSH headings : Animals; Cadaver; Endoscopes / veterinary; Eye; Horses; Lasers, Semiconductor; Light Coagulation / instrumentation; Light Coagulation / methods; Light Coagulation / veterinary; Ophthalmologic Surgical Procedures / methods; Ophthalmologic Surgical Procedures / veterinary
topics (OpenAlex): Glaucoma and retinal disorders; Corneal surgery and disorders; Intraocular Surgery and Lenses
TL;DR: Diode ECP between 0.90 and 1.14 J is a potential treatment option for glaucoma in horses based on visible tissue effects and target ciliary epithelium damage and may limit the use of an anterior chamber approach in phakic horses. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 chapter

Diseases and surgery of the cornea

In K. N. Gelatt, B. C. Gilger, & T. J. Kern (Eds.), Veterinary Ophthalmology (5th ed.). Ames, Iowa: Wiley-Blackwell.

By: E. Ledbetter & B. Gilger

Ed(s): K. Gelatt, B. Gilger & T. Kern

Source: NC State University Libraries
Added: October 20, 2020

2013 journal article

Effect of Choroidal Perfusion on Ocular Tissue Distribution After Intravitreal or Suprachoroidal Injection in an Arterially Perfused Ex Vivo Pig Eye Model

Journal of Ocular Pharmacology and Therapeutics, 29(8), 715–722.

By: E. Abarca n, J. Salmon n & B. Gilger n

MeSH headings : Animals; Carbocyanines / pharmacokinetics; Choroid / blood supply; Choroid / drug effects; Choroid / metabolism; Ciliary Arteries; Drug Delivery Systems; Female; Fluorescein / pharmacokinetics; In Vitro Techniques; Intravitreal Injections; Male; Metabolic Clearance Rate; Microcirculation; Microscopy, Fluorescence; Perfusion; Regional Blood Flow; Swine; Tissue Distribution; Vitreous Body / blood supply; Vitreous Body / drug effects; Vitreous Body / metabolism
topics (OpenAlex): Retinal Diseases and Treatments; Glaucoma and retinal disorders; Retinal Development and Disorders
TL;DR: Choroidal circulation reduces the tissue drug concentration of the hydrophilic drug suggesting an early clearance mechanism after SCS delivery, which is higher in nonperfused eyes compared to perfused eyes. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2013 chapter

Eosinophilic keratoconjunctivitis in a dog

In K. N. Gelatt, B. C. Gilger, & T. J. Kern (Eds.), Veterinary Ophthalmology (5th edition). Ames, Iowa: Wiley-Blackwell.

By: J. Hempstead, R. McMullen & B. Gilger

Ed(s): K. Gelatt, B. Gilger & T. Kern

Source: NC State University Libraries
Added: December 22, 2020

2013 chapter

Equine ophthalmology

In K. N. Gelatt, B. C. Gilger, & T. J. Kern (Eds.), Veterinary Ophthalmology (5th ed.). Ames, Iowa: Wiley-Blackwell.

By: B. Gilger

Ed(s): K. Gelatt, B. Gilger & T. Kern

Source: NC State University Libraries
Added: October 20, 2020

2013 journal article

Histopathologic features of equine superficial, nonhealing, corneal ulcers

Veterinary Ophthalmology, 17(s1), 46–52.

By: J. Hempstead, A. Clode n, B. Salmon & B. Gilger n

author keywords: corneal; equine; indolent; nonhealing; superficial; ulcer
MeSH headings : Animals; Cornea / pathology; Corneal Stroma / pathology; Corneal Ulcer / pathology; Corneal Ulcer / veterinary; Epithelium, Corneal / pathology; Female; Horse Diseases / pathology; Horses; Male; Retrospective Studies
topics (OpenAlex): Ocular Infections and Treatments; Bee Products Chemical Analysis; Coccidia and coccidiosis research
TL;DR: The most consistent histopathological characteristics of equine chronic, nonhealing, superficial, corneal ulcers include epithelial nonadherence, epithelial dysmaturity and mild to moderate stromal inflammation; however, one set of histopathology characteristics does not definitively define this syndrome in horses. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice

TOXICOLOGY AND APPLIED PHARMACOLOGY, 272(2), 503–518.

By: J. Harrill*, R. Hukkanen*, M. Lawson*, G. Martin*, B. Gilger n, V. Soldatow*, E. LeCluyse*, R. Budinsky* ...

author keywords: Aryl hydrocarbon receptor knockout rat; Aryl hydrocarbon receptor knockout mouse; Comparison; Tissue phenotypes; Liver; Kidney
MeSH headings : Animals; Gene Deletion; Gene Knockdown Techniques; Kidney / drug effects; Kidney / metabolism; Kidney / pathology; Liver / drug effects; Liver / metabolism; Liver / pathology; Mice; Mice, Knockout; Organ Size / genetics; Phenotype; Polychlorinated Dibenzodioxins / toxicity; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon / genetics; Receptors, Aryl Hydrocarbon / metabolism; Species Specificity
topics (OpenAlex): Toxic Organic Pollutants Impact; Effects and risks of endocrine disrupting chemicals; Carcinogens and Genotoxicity Assessment
TL;DR: The present data indicate that the AHR may play significantly different roles in tissue development and homeostasis and toxicity across rodent species. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 chapter

Ocular Immunology

In K. N. Gelatt, B. C. Gilger, & T. J. Kern (Eds.), Veterinary Ophthalmology (5th ed.). Wiley Blackwell.

By: R. English & B. Gilger

Ed(s): K. Gelatt, B. Gilger & T. Kern

Source: NC State University Libraries
Added: October 20, 2020

2013 journal article

Phacoemulsification and +14 diopter intraocular lens placement in a Saddlebred foal

VETERINARY OPHTHALMOLOGY, 16(2), 140–148.

By: J. Harrington n, R. McMullen n, A. Clode n & B. Gilger n

author keywords: cataract; equine phacoemulsification; foal; intraocular lens; ocular ultrasound; retinoscopy
MeSH headings : Animals; Cataract / pathology; Cataract / therapy; Cataract / veterinary; Cataract Extraction / methods; Cataract Extraction / veterinary; Female; Horse Diseases / surgery; Horse Diseases / therapy; Horses; Lens Implantation, Intraocular / veterinary; Phacoemulsification / veterinary
topics (OpenAlex): Intraocular Surgery and Lenses; Veterinary Equine Medical Research; Plant Toxicity and Pharmacological Properties
TL;DR: A +14 diopter (D) intraocular lens (IOL) IOL may be the appropriate choice following lens extraction in a foal to achieve refraction near emmetropia at maturity at maturity. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 chapter

Selection of Appropriate Animal Models in Ocular Research: Ocular Anatomy and Physiology of Common Animal Models

In Methods in Pharmacology and Toxicology (pp. 7–32).

By: B. Gilger n, E. Abarca n & J. Salmon n

topics (OpenAlex): Retinal Development and Disorders; Zebrafish Biomedical Research Applications; Retinoids in leukemia and cellular processes
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2013 journal article

The effect of 1% tropicamide-induced mydriasis and cycloplegia on spherical refraction of the adult horse

Veterinary Ophthalmology, 17(2), 120–125.

By: R. McMullen n, M. Davidson n & B. Gilger n

author keywords: cycloplegia; equine ophthalmology; mydriasis; pupillometry; streak retinoscopy; tropicamide
MeSH headings : Animals; Eye / drug effects; Female; Horses; Muscarinic Antagonists / administration & dosage; Muscarinic Antagonists / pharmacology; Mydriasis / chemically induced; Mydriasis / veterinary; Tropicamide / administration & dosage; Tropicamide / pharmacology
topics (OpenAlex): Glaucoma and retinal disorders; Corneal surgery and disorders; Ophthalmology and Visual Impairment Studies
TL;DR: Optimal streak retinoscopy results may be obtained prior to, or 40- to 45-min following the application of topical tropicamide 1%, once near-maximal dilation has been achieved. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

Treatment of Acute Posterior Uveitis in a Porcine Model by Injection of Triamcinolone Acetonide Into the Suprachoroidal Space Using Microneedles

Investigative Opthalmology & Visual Science, 54(4), 2483.

By: B. Gilger n, E. Abarca n, J. Salmon n & S. Patel*

author keywords: drug delivery; suprachoroidal space; microneedle; posterior segment; uveitis
MeSH headings : Acute Disease; Animals; Aqueous Humor / cytology; Aqueous Humor / metabolism; Cell Count; Choroid; Disease Models, Animal; Electroretinography / drug effects; Extracellular Space; Eye Proteins / metabolism; Female; Glucocorticoids / therapeutic use; Intraocular Pressure / drug effects; Intravitreal Injections; Leukocytes / pathology; Male; Needles; Sus scrofa; Tomography, Optical Coherence; Triamcinolone Acetonide / therapeutic use; Uveitis, Posterior / drug therapy; Uveitis, Posterior / pathology; Vitreous Body / metabolism; Vitreous Body / pathology
topics (OpenAlex): Retinal Diseases and Treatments; Glaucoma and retinal disorders
TL;DR: Delivery of TA to the SCS using microneedles was simple, effective, and not associated with adverse effects or toxicity, and there were no adverse effects, increased IOP, or evidence of procedural or drug toxicity following injection of TA into theSCS in porcine eyes. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

Treatment of immune-mediated keratitis in horses with episcleral silicone matrix cyclosporine delivery devices

Veterinary Ophthalmology, 17, 23–30.

By: B. Gilger n, R. Stoppini, D. Wilkie*, A. Clode n, N. Pinto n, J. Hempstead n, J. Gerding n, J. Salmon n

author keywords: cyclosporine; horse; immune-mediated; keratitis; sustained release
MeSH headings : Animals; Cyclosporine / administration & dosage; Cyclosporine / therapeutic use; Drug Implants / administration & dosage; Female; Horse Diseases / drug therapy; Horses; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / therapeutic use; Keratitis / drug therapy; Keratitis / veterinary; Male; Sclera; Silicones; Treatment Outcome
topics (OpenAlex): Ocular Infections and Treatments; Ocular Surface and Contact Lens; Corneal surgery and disorders
TL;DR: Results from this preliminary retrospective study suggest that the ESMC implants were well tolerated and associated with treatment success with superficial and endothelial IMMK, especially if placed early in the disease process. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2013 book

Veterinary Ophthalmology

(5th ed.). Ames, Iowa: Wiley-Blackwell.

Brian Gilger

Ed(s): K. Gelatt, B. Gilger & T. Kern

Source: NC State University Libraries
Added: July 27, 2021

2012 journal article

A retrospective comparison of surgical removal and subsequent CO2 laser ablation versus topical administration of mitomycin C as therapy for equine corneolimbal squamous cell carcinoma

VETERINARY OPHTHALMOLOGY, 15(4), 254–262.

By: A. Clode n, C. Miller, R. McMullen n & B. Gilger n

author keywords: cornea; equine; mitomycin; squamous cell carcinoma
MeSH headings : Administration, Topical; Animals; Antibiotics, Antineoplastic / administration & dosage; Antibiotics, Antineoplastic / therapeutic use; Carcinoma, Squamous Cell / drug therapy; Carcinoma, Squamous Cell / surgery; Carcinoma, Squamous Cell / veterinary; Eye Neoplasms / drug therapy; Eye Neoplasms / surgery; Eye Neoplasms / veterinary; Female; Horse Diseases / drug therapy; Horse Diseases / surgery; Horse Diseases / therapy; Horses; Lasers, Gas / therapeutic use; Male; Mitomycin / administration & dosage; Mitomycin / therapeutic use; Ophthalmologic Surgical Procedures / methods; Ophthalmologic Surgical Procedures / veterinary; Retrospective Studies
topics (OpenAlex): Ocular Infections and Treatments; Infectious Diseases and Mycology; Corneal Surgery and Treatments
TL;DR: Horses receiving adjunctive topical MMC therapy were no more likely to experience tumor recurrence than were horses undergoing CO(2) laser ablation in the horses in this study. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

A topical aqueous calcineurin inhibitor for the treatment of naturally occurring keratoconjunctivitis sicca in dogs

Veterinary Ophthalmology, 16(3), 192–197.

By: B. Gilger n, D. Wilkie*, J. Salmon n & M. Peel*

author keywords: calcineurin inhibitor; canine; clinical trial; keratoconjunctivitis sicca
MeSH headings : Administration, Topical; Animals; Calcineurin Inhibitors; Cyclosporins / pharmacology; Dog Diseases / drug therapy; Dogs; Double-Blind Method; Keratoconjunctivitis Sicca / drug therapy; Keratoconjunctivitis Sicca / veterinary; Pilot Projects
topics (OpenAlex): Ocular Surface and Contact Lens; Corneal Surgery and Treatments; Ocular Infections and Treatments
TL;DR: Results indicate that topical SCY-641, in a stable clear aqueous solution, is efficacious in a spontaneous model of KCS and warrants further evaluation as a treatment of immune-mediated KCS. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2012 journal article

Carbon dioxide laser photoablation adjunctive therapy following superficial lamellar keratectomy and bulbar conjunctivectomy for the treatment of corneolimbal squamous cell carcinoma in horses: a review of 24 cases

VETERINARY OPHTHALMOLOGY, 15(4), 245–253.

By: T. Michau, M. Davidson n & B. Gilger n

author keywords: carbon dioxide laser; cornea; equine; limbus; ophthalmology; squamous cell carcinoma
MeSH headings : Animals; Carcinoma, Squamous Cell / surgery; Carcinoma, Squamous Cell / veterinary; Corneal Surgery, Laser / veterinary; Eye Neoplasms / surgery; Eye Neoplasms / veterinary; Female; Horse Diseases / surgery; Horses; Lasers, Gas / therapeutic use; Male; Ophthalmologic Surgical Procedures / methods; Ophthalmologic Surgical Procedures / veterinary; Retrospective Studies
topics (OpenAlex): Ocular Infections and Treatments; Corneal surgery and disorders; Veterinary Oncology Research
TL;DR: CO(2) photoablation appears to be effective as an adjunctive therapy following removal of large corneolimbal SCC in the horse and in cases in which all tumor cells were not excised. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Evaluation of diode endoscopic cyclophotocoagulation in bovine cadaver eyes

AMERICAN JOURNAL OF VETERINARY RESEARCH, 73(9), 1445–1452.

By: J. Harrington n, R. McMullen, J. Cullen* & B. Gilger*

MeSH headings : Animals; Cadaver; Cattle; Cattle Diseases / pathology; Cattle Diseases / surgery; Endoscopy / methods; Endoscopy / veterinary; Glaucoma / pathology; Glaucoma / surgery; Glaucoma / veterinary; Histocytochemistry; Laser Coagulation / instrumentation; Laser Coagulation / methods; Laser Coagulation / veterinary
topics (OpenAlex): Glaucoma and retinal disorders; Corneal surgery and disorders; Retinal Diseases and Treatments
TL;DR: Evaluating the anterior chamber approach and energy levels for endoscopic cyclophotocoagulation (ECPC) and assessing ECPC-induced tissue damage in phakic eyes of bovine cadavers found the 0.75- and 0.90-J energy levels had the potential to effectively treat the ciliary epithelium. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Extraocular lymphoma in the horse

Veterinary Ophthalmology, 16(1), 35–42.

By: A. Schnoke*, D. Brooks*, D. Wilkie*, A. Dwyer, A. Matthews*, B. Gilger n, D. Hendrix*, P. Pickett* ...

author keywords: conjunctiva; conjunctivitis; equine; extraocular; eyelid; lymphoma
MeSH headings : Animals; Conjunctival Neoplasms / diagnosis; Conjunctival Neoplasms / pathology; Conjunctival Neoplasms / veterinary; Corneal Diseases / diagnosis; Corneal Diseases / pathology; Corneal Diseases / veterinary; Eye Neoplasms / diagnosis; Eye Neoplasms / pathology; Eye Neoplasms / veterinary; Eyelid Neoplasms / diagnosis; Eyelid Neoplasms / pathology; Eyelid Neoplasms / veterinary; Female; Horse Diseases / diagnosis; Horse Diseases / pathology; Horses; Lymphoma / diagnosis; Lymphoma / pathology; Lymphoma / veterinary; Male; Prognosis; Retrospective Studies
topics (OpenAlex): Veterinary Oncology Research; Infectious Diseases and Mycology; Veterinary Equine Medical Research
TL;DR: The prognosis for clinical remission in horses with extraocular lymphoma is generally fair to good, as long as the affected tissues are completely excised, and there is no eyelid or cutaneous involvement. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2012 journal article

Immunohistochemical and immunopathologic characterization of superficial stromal immune-mediated keratitis in horses

American Journal of Veterinary Research, 73(7), 1067–1073.

By: D. Pate n, A. Clode n, T. Olivry n, J. Cullen n, J. Salmon n & B. Gilger n

Contributors: D. Pate n, A. Clode n, T. Olivry n, J. Cullen n, J. Salmon n & B. Gilger n

topics (OpenAlex): Ocular Surface and Contact Lens; Plant Toxicity and Pharmacological Properties; Ocular Infections and Treatments
TL;DR: Pathogenesis of superficial stromal immune-mediated keratitis included cell-mediated inflammation governed by both cytotoxic and helper T cells and local immunoglobulins were present in affected corneas; however, corneal-binding immunoglolins were not detected in the serum or AH from horses with IMMK. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 chapter

Ophthalmic disorders

In D. A. Wilson (Ed.), Clinical Veterinary Advisor, The Horse. St. Louis, MO: Elsevier Saunders.

By: B. Gilger

Ed(s): D. Wilson

Source: NC State University Libraries
Added: October 20, 2020

2012 journal article

Sustained-Release Celecoxib from Incubated Acrylic Intraocular Lenses Suppresses Lens Epithelial Cell Growth in an Ex Vivo Model of Posterior Capsule Opacity

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, 28(4), 359–368.

By: J. Davis n, N. Yi n, J. Salmon n, A. Charlton n, C. Colitz n & B. Gilger n

MeSH headings : Animals; Cataract Extraction; Celecoxib; Corneal Opacity / pathology; Corneal Opacity / prevention & control; Cyclooxygenase 2 Inhibitors / administration & dosage; Cyclooxygenase 2 Inhibitors / pharmacokinetics; Cyclooxygenase 2 Inhibitors / therapeutic use; Delayed-Action Preparations; Dogs; Epithelial Cells / drug effects; Epithelium / drug effects; Epithelium / growth & development; In Vitro Techniques; Lens, Crystalline / cytology; Lens, Crystalline / drug effects; Lens, Crystalline / growth & development; Lenses, Intraocular; Polymethyl Methacrylate; Posterior Capsule of the Lens / cytology; Posterior Capsule of the Lens / drug effects; Posterior Capsule of the Lens / pathology; Postoperative Complications / pathology; Postoperative Complications / prevention & control; Pyrazoles / administration & dosage; Pyrazoles / pharmacokinetics; Pyrazoles / therapeutic use; Sulfonamides / administration & dosage; Sulfonamides / pharmacokinetics; Sulfonamides / therapeutic use
topics (OpenAlex): Intraocular Surgery and Lenses; Anesthesia and Pain Management; Inflammatory mediators and NSAID effects
TL;DR: A 4-day treatment of LCs with a concentration of 20 μM CXB may effectively prevent PCO and further studies are needed to determine whether C XB-incubated IOLs can effectively prevent the development of PCO in vivo. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 article

The search for causes of nonhealing or recurrent ulcerative keratitis in horses

Gilger, B. C. (2012, November). EQUINE VETERINARY EDUCATION, Vol. 24, pp. 561–562.

By: B. Gilger n

author keywords: horse; cornea; ulcer; chronic; recurrent; distichiasis
topics (OpenAlex): Ocular Infections and Treatments; Ocular Surface and Contact Lens; Entomological Studies and Ecology
TL;DR: Common causes of chronic or recurrent superficial ulcerative keratitis, such as infectious keratritis, should always be ruled out; however, other possible causes such as single or multiple distichiasis, should be considered. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Aqueous humor and plasma concentrations of a compounded 0.2% solution of terbinafine following topical ocular administration to normal equine eyes

Veterinary Ophthalmology, 14(1), 41–47.

By: A. Clode n, J. Davis n, G. Davidson n, J. Salmon n, H. Lafevers n & B. Gilger n

author keywords: aqueous humor; equine; keratomycosis; terbinafine
MeSH headings : Absorption; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / analysis; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Aqueous Humor / chemistry; Chromatography, High Pressure Liquid / veterinary; Cornea / metabolism; Female; Horses / metabolism; Male; Naphthalenes / administration & dosage; Naphthalenes / analysis; Naphthalenes / blood; Naphthalenes / pharmacokinetics; Ophthalmic Solutions; Terbinafine
topics (OpenAlex): Ocular Infections and Treatments; Ocular Surface and Contact Lens; Antimicrobial Peptides and Activities
TL;DR: Topical ocular administration of compounded 0.2% terbinafine solution does not result in detectable AH or plasma levels following administration to normal equine eyes, suggesting its use for deep corneal or intraocular fungal infections in equine ophthalmology may be limited. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2011 journal article

Challenges in the treatment of equine periocular squamous cell carcinoma

EQUINE VETERINARY EDUCATION, 23(10), 500–501.

By: B. Gilger n

author keywords: horse; ocular; squamous cell carcinoma; metastasis; treatment
topics (OpenAlex): Infectious Diseases and Mycology; Veterinary Oncology Research; Salivary Gland Tumors Diagnosis and Treatment
TL;DR: Management of periocular squamous cell carcinoma is challenging because of the need for adjunctive therapy, the adverse effects of therapies and the frequent recurrence of SCC. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

Concerns with analysis of correlated eye data

Veterinary Ophthalmology, 14(3), 214–214.

By: B. Gilger n

MeSH headings : Animals; Clinical Trials as Topic / methods; Clinical Trials as Topic / veterinary; Data Interpretation, Statistical; Dry Eye Syndromes / drug therapy; Dry Eye Syndromes / veterinary; Rabbits; Statistics as Topic / methods
topics (OpenAlex): Glaucoma and retinal disorders; Veterinary Oncology Research; Data-Driven Disease Surveillance
TL;DR: There continues to be studies published that do not take into account data that is highly correlated, such as the right (OD) and left eyes (OS) in a single animal, and it is recommended that a statistician be consulted to appropriately analyze this data. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

Diagnosis of intraocular lymphosarcoma in a dog by use of a polymerase chain reaction assay for antigen receptor rearrangement

Journal of the American Veterinary Medical Association, 238(5), 625–630.

By: D. Pate n, B. Gilger*, S. Suter* & A. Clode*

MeSH headings : Animals; Antineoplastic Agents / therapeutic use; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Eye Neoplasms / diagnosis; Eye Neoplasms / drug therapy; Eye Neoplasms / pathology; Eye Neoplasms / veterinary; Lymphoma, Non-Hodgkin / diagnosis; Lymphoma, Non-Hodgkin / drug therapy; Lymphoma, Non-Hodgkin / veterinary; Male; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; Receptors, Antigen
topics (OpenAlex): Veterinary Oncology Research; Herpesvirus Infections and Treatments; Virus-based gene therapy research
TL;DR: In the dog of this report, intraocular lymphosarcoma was diagnosed via PARR performed on samples of aqueous humor and the immunophenotype of the neoplastic cells was determined by use of that diagnostic technique. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2011 journal article

Effect and Distribution of Contrast Medium after Injection into the Anterior Suprachoroidal Space in Ex Vivo Eyes

Investigative Opthalmology & Visual Science, 52(8), 5730.

By: G. Seiler*, J. Salmon n, R. Mantuo n, S. Feingold n, P. Dayton n & B. Gilger n

MeSH headings : Age Factors; Animals; Anterior Chamber / diagnostic imaging; Anterior Chamber / metabolism; Choroid / diagnostic imaging; Choroid / metabolism; Contrast Media / pharmacokinetics; Dogs; Drug Delivery Systems; Imaging, Three-Dimensional; In Vitro Techniques; Injections, Intraocular / methods; Latex / pharmacokinetics; Microbubbles; Posterior Eye Segment / diagnostic imaging; Posterior Eye Segment / metabolism; Retina / diagnostic imaging; Retina / metabolism; Swine; Ultrasonography
topics (OpenAlex): Glaucoma and retinal disorders; Retinal Diseases and Treatments; Cerebral Venous Sinus Thrombosis
TL;DR: The authors' hypothesis that a single anterior SCS injection can reach the ocular posterior segment was supported and it is suggested that the SCS can expand, in a dose-dependent manner, to accommodate various volumes of fluid and that it is possible to image theSCS with ultrasound contrast. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2011 article

Equine Ocular Examination

Equine Ophthalmology, pp. 1–51.

By: B. Gilger* & R. Stoppini

topics (OpenAlex): Ocular Infections and Treatments; Ocular Surface and Contact Lens; Intraocular Surgery and Lenses
Source: ORCID
Added: September 9, 2019

2011 book

Equine Ophthalmology

(2nd ed.). St. Louis, MO: Elsevier Science.

Brian Gilger

Ed(s): B. Gilger

Source: NC State University Libraries
Added: October 20, 2020

2011 chapter book

Equine Recurrent Uveitis

By: B. Gilger* & C. Deeg

topics (OpenAlex):
Sources: ORCID, Crossref, NC State University Libraries
Added: September 9, 2019

2011 chapter

Orbital disease

In B. C. Gilger (Ed.), Equine Ophthalmology (2nd ed.). St. Louis, MO: Elsevier Saunders.

By: B. Gilger

Ed(s): B. Gilger

Source: NC State University Libraries
Added: October 20, 2020

2011 journal article

Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration

British Journal of Ophthalmology, 95(12), 1749–1754.

By: J. Sommer n, J. Estrada n, E. Collins n, M. Bedell*, C. Alexander n, Z. Yang*, G. Hughes*, B. Mir n ...

MeSH headings : Animals; Animals, Genetically Modified; Disease Models, Animal; Electroretinography; Eye Proteins / biosynthesis; Eye Proteins / genetics; Gene Deletion; Immunohistochemistry; Macular Degeneration / metabolism; Macular Degeneration / pathology; Macular Degeneration / physiopathology; Membrane Proteins / biosynthesis; Membrane Proteins / genetics; Microscopy, Fluorescence; Mutation; Retina / metabolism; Retina / pathology; Retina / physiopathology; Swine
topics (OpenAlex): Animal Genetics and Reproduction; Retinal Development and Disorders; CRISPR and Genetic Engineering
TL;DR: These transgenic pigs provide unique animal models for examining macular degeneration and STGD3 pathogenesis and direct fluorescence microscopy indicated that the Y270terEYFP protein is expressed in photoreceptors and mislocalised within the cell. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2011 chapter

Suprachoroidal and intrascleral drug delivery

In U. Kompella & H. Edelhauser (Eds.), Drug Product Development for the Back of the Eye. New York: Springer Publications.

By: B. Gilger & T. Olsen

Ed(s): U. Kompella & H. Edelhauser

Source: NC State University Libraries
Added: October 20, 2020

2010 journal article

Advancements in ocular drug delivery

Veterinary Ophthalmology, 13(6), 395–406.

By: A. Weiner* & B. Gilger n

author keywords: drug delivery; eye; implants; therapeutics; veterinary
MeSH headings : Administration, Topical; Animals; Delayed-Action Preparations; Drug Delivery Systems / veterinary; Eye Diseases / drug therapy; Eye Diseases / veterinary; Prostheses and Implants / veterinary
topics (OpenAlex): Advanced Drug Delivery Systems; Ocular Surface and Contact Lens; Advancements in Transdermal Drug Delivery
TL;DR: In addition to addressing the physiologic challenges of achieving the necessary duration of delivery, tissue targeting and patient compliance, the commercial development factors of biocompatibility, sterilization, manufacturability and long-term stability will be discussed. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

Aqueous humor and plasma concentrations of ciprofloxacin and moxifloxacin following topical ocular administration in ophthalmologically normal horses

American Journal of Veterinary Research, 71(5), 564–569.

By: A. Clode n, J. Davis*, J. Salmon*, H. LaFevers & B. Gilger*

MeSH headings : Administration, Oral; Administration, Topical; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / metabolism; Aqueous Humor / metabolism; Aza Compounds / administration & dosage; Aza Compounds / blood; Aza Compounds / metabolism; Ciprofloxacin / administration & dosage; Ciprofloxacin / blood; Ciprofloxacin / metabolism; Female; Fluoroquinolones; Horses / blood; Horses / metabolism; Male; Moxifloxacin; Orchiectomy / veterinary; Quinolines / administration & dosage; Quinolines / blood; Quinolines / metabolism
topics (OpenAlex): Ocular Infections and Treatments; Antibiotics Pharmacokinetics and Efficacy; Intraocular Surgery and Lenses
TL;DR: Moxifloxacin was better able to penetrate healthy equine corneas and reach measurable AH concentrations than was ciprofloxacIn, suggesting moxif loxac in might be of greater value in the treatment of deep corneal or intraocular bacterial infections caused by susceptible organisms. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2010 journal article

CASE REPORT: Anomalous nasolacrimal openings in a 2-year-old Morgan filly

Veterinary Ophthalmology, 13(5), 339–342.

By: B. Gilger n, J. Histed n, D. Pate n, A. Clode n & R. McMullen n

author keywords: computed tomography; congenital; epiphora; equine; nasolacrimal duct
MeSH headings : Animals; Female; Horse Diseases / pathology; Horse Diseases / surgery; Horses / abnormalities; Nasolacrimal Duct / abnormalities; Nasolacrimal Duct / surgery
topics (OpenAlex): Nasolacrimal Duct Obstruction Treatments; Glaucoma and retinal disorders; Neonatal Health and Biochemistry
TL;DR: This case report describes the clinical, diagnostic, computed tomography findings, and surgical treatment of a 2-year-old Morgan filly with bilateral, proximal, and distal anomalous nasolacrimal duct openings. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2010 journal article

Effect of three treatment protocols on acute ocular hypertension after phacoemulsification and aspiration of cataracts in dogs

Veterinary Ophthalmology, 13(1), 14–19.

By: M. Crasta, A. Clode n, R. McMullen n, D. Pate n & B. Gilger n

author keywords: carbachol; cataract; dogs; IOP; latanoprost; phacoemulsification
MeSH headings : Administration, Topical; Animals; Carbachol / therapeutic use; Cataract Extraction / adverse effects; Cataract Extraction / veterinary; Dog Diseases / drug therapy; Dog Diseases / prevention & control; Dog Diseases / surgery; Dogs; Intraocular Pressure / drug effects; Latanoprost; Ocular Hypertension / etiology; Ocular Hypertension / prevention & control; Ocular Hypertension / veterinary; Phacoemulsification / adverse effects; Phacoemulsification / veterinary; Postoperative Period; Prostaglandins F, Synthetic / therapeutic use; Retrospective Studies
topics (OpenAlex): Intraocular Surgery and Lenses; Ocular Surface and Contact Lens; Connexins and lens biology
TL;DR: Topical 0.005% latanoprost or intracameral injection after PA in dogs did not reduce POH or increase intraocular inflammation compared to dogs not receiving adjunctive therapy after PA of cataracts. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2010 journal article

Equine immune-mediated keratopathies

Equine Veterinary Journal, 42(S37), 31–37.

By: A. Matthews* & B. Gilger n

MeSH headings : Animals; Anti-Inflammatory Agents / therapeutic use; Corneal Diseases / drug therapy; Corneal Diseases / epidemiology; Corneal Diseases / immunology; Corneal Diseases / pathology; Corneal Diseases / veterinary; Horse Diseases / drug therapy; Horse Diseases / epidemiology; Horse Diseases / immunology; Horse Diseases / pathology; Horses; Immunosuppressive Agents / therapeutic use; United Kingdom / epidemiology; United States / epidemiology
topics (OpenAlex): Ocular Surface and Contact Lens; Ocular Infections and Treatments; Corneal Surgery and Treatments
TL;DR: The currently recognised clinical presentations of the IMMKs in the USA and in the UK are described and recurrence or refractoriness to treatment is possible. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: September 9, 2019

2010 journal article

Equine recurrent uveitis: The viewpoint from the USA

Equine Veterinary Journal, 42(S37), 57–61.

By: B. Gilger n

MeSH headings : Animals; Anti-Inflammatory Agents / therapeutic use; Horse Diseases / epidemiology; Horse Diseases / pathology; Horse Diseases / therapy; Horses; Leptospirosis / complications; Leptospirosis / veterinary; Recurrence; United States / epidemiology; Uveitis / epidemiology; Uveitis / pathology; Uveitis / therapy; Uveitis / veterinary
topics (OpenAlex): Leptospirosis research and findings; Brucella: diagnosis, epidemiology, treatment; Mycobacterium research and diagnosis
TL;DR: Standard symptomatic anti-inflammatory therapy is effective to control most cases of ERU; however, some horses require advanced therapy, such as placement of drug delivery devices or removal of the vitreous, when they fail to respond to the standard therapy. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: July 21, 2019

2010 journal article

Evaluation of 30- and 25-diopter intraocular lens implants in equine eyes after surgical extraction of the lens

American Journal of Veterinary Research, 71(7), 809–816.

By: R. McMullen n, M. Davidson n, N. Campbell n, J. Salmon n & B. Gilger n

MeSH headings : Animals; Anterior Chamber / surgery; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / therapeutic use; Euthanasia, Animal; Eye Enucleation / methods; Eye Enucleation / veterinary; Horse Diseases / surgery; Horses; Lens Implantation, Intraocular / methods; Lens Implantation, Intraocular / veterinary; Lens, Crystalline / anatomy & histology; Lens, Crystalline / surgery; Lenses, Intraocular / veterinary; Refraction, Ocular / physiology; Refractive Errors / therapy; Refractive Errors / veterinary; Refractive Surgical Procedures / methods; Refractive Surgical Procedures / veterinary
topics (OpenAlex): Intraocular Surgery and Lenses; Corneal surgery and disorders; Ocular Infections and Treatments
TL;DR: Investigation of intraocular lens (IOL) implant strength to approximate emmetropia in horses found insertion of 30-D (enucleated globes) and 25-D IOL implants (adult horses) resulted in overcorrection of refractive error. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2010 journal article

Long-term outcome after implantation of a suprachoroidal cyclosporine drug delivery device in horses with recurrent uveitis

Veterinary Ophthalmology, 13(5), 294–300.

By: B. Gilger n, D. Wilkie*, A. Clode n, R. McMullen n, M. Utter, A. Komaromy*, D. Brooks*, J. Salmon n

author keywords: cyclosporine; equine; implant; recurrent uveitis
MeSH headings : Animals; Cyclosporine / administration & dosage; Cyclosporine / therapeutic use; Female; Horse Diseases / drug therapy; Horses; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / therapeutic use; Infusion Pumps, Implantable / veterinary; Male; Uveitis / drug therapy; Uveitis / veterinary
topics (OpenAlex): Cytomegalovirus and herpesvirus research; Leptospirosis research and findings
TL;DR: The increased vision loss related to uveitis episode of inflammation in eyes after the likely depletion of CsA from the CSI suggests that a repeat CSI may be required at or before 48 months after surgery. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2010 journal article

Ophthalmic Drug Delivery Systems for the Treatment of Retinal Diseases: Basic Research to Clinical Applications

Investigative Opthalmology & Visual Science, 51(11), 5403.

By: H. Edelhauser*, C. Rowe-Rendleman, M. Robinson*, D. Dawson*, G. Chader*, H. Grossniklaus*, K. Rittenhouse*, C. Wilson* ...

MeSH headings : Biomedical Research; Drug Delivery Systems; Humans; Ophthalmic Solutions / administration & dosage; Pharmaceutical Preparations / administration & dosage; Retinal Diseases / drug therapy
topics (OpenAlex): Retinal Diseases and Treatments; Retinal Development and Disorders; Retinopathy of Prematurity Studies
TL;DR: The basic science part of this article focuses on the anatomic barriers to the five major modes of ocular drug delivery: intraocular, periocular, hybrid, topical, and systemic. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019

2010 journal article

Topical delivery of hydrophobic drugs using a novel mixed nanomicellar technology to treat diseases of the anterior and posterior segments of the eye

Drug Delivery Technology, 10(4), 42–47.

By: P. Velagaleti, E. Anglade, I. Khan, B. Gilger & A. Mitra

Source: NC State University Libraries
Added: October 20, 2020

2009 journal article

Comparison of capsular opacification and refractive status after placement of three different intraocular lens implants following phacoemulsification and aspiration of cataracts in dogs

Veterinary Ophthalmology, 12(1), 13–21.

By: B. Gift*, R. English*, B. Nadelstein*, A. Weigt* & B. Gilger n

author keywords: design; dog; intraocular lens; material; posterior capsular opacification; refractive error
MeSH headings : Acrylic Resins; Animals; Cataract / veterinary; Cataract Extraction / instrumentation; Cataract Extraction / methods; Cataract Extraction / veterinary; Dog Diseases / surgery; Dogs; Female; Lens Implantation, Intraocular / instrumentation; Lens Implantation, Intraocular / methods; Lens Implantation, Intraocular / veterinary; Male; Phacoemulsification / veterinary; Polymethyl Methacrylate; Prosthesis Design; Random Allocation; Treatment Outcome
topics (OpenAlex): Intraocular Surgery and Lenses; Glaucoma and retinal disorders; Ocular Infections and Treatments
TL;DR: Square edged foldable acrylic IOLs show a predisposition towards generating slightly less PCO than round edged PMMA I OLs in the early postoperative period, however, both acrylic Iols had greater persistent hyperopia than the PMMAIOLs. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2009 chapter

Enucleation

In N. E. Robinson & K. A. Sprayberry (Eds.), Current Therapy in Equine Medicine (6th ed.). St. Louis, MO: Saunders Elsevier.

By: B. Gilger

Ed(s): N. Robinson & K. Sprayberry

Source: NC State University Libraries
Added: October 20, 2020

2009 chapter

Equine Recurrent Uveitis

In N. E. Robinson & K. A. Sprayberry (Eds.), Current Therapy in Equine Medicine (6th ed.). St. Louis, Missouri: Elsevier Saunders.

By: B. Gilger

Ed(s): N. Robinson & K. Sprayberry

Source: NC State University Libraries
Added: February 2, 2024

2009 journal article

Equine immune-mediated keratopathies

Veterinary Ophthalmology, 12, 10–16.

By: A. Matthews* & B. Gilger n

author keywords: cornea; equine; immune-mediated; keratitis; nonulcerative
MeSH headings : Animals; Horse Diseases / immunology; Horse Diseases / pathology; Horses; Keratitis / immunology; Keratitis / pathology; Keratitis / veterinary
topics (OpenAlex): Ocular Surface and Contact Lens; Ocular Infections and Treatments; Corneal Surgery and Treatments
TL;DR: The clinical differences in horses with this disease are compared and the current theories on pathogenesis and treatment of equine IMMK are reviewed. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Infrared digital imaging of the equine anterior segment

Veterinary Ophthalmology, 12(2), 125–131.

By: R. McMullen Jr., A. Clode n & B. Gilger n

author keywords: anterior segment; corneal disease; digital infrared photography; equine; melanoma; equine ophthalmology
MeSH headings : Animals; Eye / anatomy & histology; Eye Diseases / diagnosis; Eye Diseases / veterinary; Horse Diseases / diagnosis; Horses / anatomy & histology; Infrared Rays; Ophthalmology / instrumentation; Ophthalmology / methods; Photography / instrumentation; Photography / methods; Photography / veterinary
topics (OpenAlex): Veterinary Equine Medical Research; Effects of Environmental Stressors on Livestock; Infrared Thermography in Medicine
TL;DR: In the equine eye, advantages of infrared digital photography include increased contrast of anterior segment images, identification and monitoring of pigmentary changes, and increased visualization of the anterior segment through a cloudy or edematous cornea. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2009 article

International Equine Ophthalmology Consortium (IEOC) Symposium

Gilger, B. C., & Brooks, D. E. (2009, July). EQUINE VETERINARY JOURNAL, Vol. 41, pp. 606–607.

By: B. Gilger n & D. Brooks*

author keywords: horse; ophthalmology; workshop; Havemeyer; International Equine Ophthalmology Consortium
MeSH headings : Animals; Eye Diseases / diagnosis; Eye Diseases / therapy; Eye Diseases / veterinary; Horse Diseases / diagnosis; Horse Diseases / therapy; Horses; Ophthalmologic Surgical Procedures / veterinary
topics (OpenAlex): Ocular Infections and Treatments; Photodynamic Therapy Research Studies; Corneal Surgery and Treatments
TL;DR: Development of an IEOC membership organisation and website was discussed and supported by the group in an effort further to advance the science of equine ophthalmology. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Quantitative differences in mRNA expression of Toll-like receptor (TLR)-2, -4, and -9 in normal equine eyes and eyes with equine recurrent uveitis.

Journal of Veterinary Clinics, 26(6), 520–523.

By: N. Yi, J. Salmon & B. Gilger

Source: NC State University Libraries
Added: December 22, 2020

2009 journal article

Surgical correction of severe strabismus and enophthalmos secondary to zygomatic arch fracture in a dog

Veterinary Ophthalmology, 12(2), 119–124.

By: K. Konrade n, A. Clode n, T. Michau n, S. Roe n, B. Trumpatori n, W. Krug n, B. Gilger n

author keywords: dog; fracture; miniplate fixation; orbital rim
MeSH headings : Animals; Bone Plates / veterinary; Dog Diseases / surgery; Dogs; Enophthalmos / surgery; Enophthalmos / veterinary; Male; Strabismus / surgery; Strabismus / veterinary; Zygomatic Fractures / surgery; Zygomatic Fractures / veterinary
topics (OpenAlex): Facial Trauma and Fracture Management; Traumatic Ocular and Foreign Body Injuries; Craniofacial Disorders and Treatments
TL;DR: A grossly displaced segmental zygomatic arch fracture with marked ventro-lateral deviation of the left globe was diagnosed in a 3-month-old male German Shepherd dog following a bite injury and surgical correction achieved sufficient skeletal fixation for proper anatomical reduction of the globe. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2008 journal article

A moment of SCIENCE . . . Please!

Veterinary Ophthalmology, 11(5), 279–279.

By: B. Gilger* & E. Bentley*

MeSH headings : Animals; Evidence-Based Medicine; Ophthalmology / education; Veterinary Medicine / standards
topics (OpenAlex): Health Sciences Research and Education; Health and Medical Research Impacts; Meta-analysis and systematic reviews
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2008 journal article

Epibulbar melanoma in a foal

Veterinary Ophthalmology, 11, 44–50.

By: R. McMullen n, A. Clode*, A. Pandiri n, D. Malarkey*, T. Michau* & B. Gilger*

author keywords: congenital; epibulbar; equine; melanoma; neoplasia
MeSH headings : Animals; Animals, Newborn; Choroid Neoplasms / pathology; Choroid Neoplasms / surgery; Choroid Neoplasms / veterinary; Eye Enucleation / methods; Eye Enucleation / veterinary; Eye Neoplasms / pathology; Eye Neoplasms / surgery; Eye Neoplasms / veterinary; Horse Diseases / pathology; Horse Diseases / surgery; Horses; Limbus Corneae; Macrophages / pathology; Male; Melanoma / pathology; Melanoma / surgery; Melanoma / veterinary; Pigment Epithelium of Eye / pathology; Treatment Outcome
topics (OpenAlex): Veterinary Oncology Research; Cutaneous Melanoma Detection and Management; Microbial infections and disease research
TL;DR: Based on the sudden onset and rapid growth as well as the histological evidence of invasion, well-differentiated features, heavy pigmentation, and no apparent mitoses, this neoplasm was considered to be a low-grade malignant melanoma. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2008 journal article

Equine special edition of veterinary ophthalmology

Veterinary Ophthalmology, 11, 1–1.

By: B. Gilger n

MeSH headings : Animals; Eye Diseases / diagnosis; Eye Diseases / therapy; Eye Diseases / veterinary; Horse Diseases / diagnosis; Horse Diseases / therapy; Horses; Ophthalmology / methods; Veterinary Medicine / methods
topics (OpenAlex): Veterinary Oncology Research; Mast cells and histamine; Infectious Diseases and Mycology
TL;DR: This equine special edition of Veterinary Ophthalmology demonstrates that the field of equine ophthalmology is meeting the challenge, however, much more work is needed regarding characterization of specific equine diseases and the development of effective, safe, and practical treatments. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2008 journal article

Immunology of the Ocular Surface

Veterinary Clinics of North America: Small Animal Practice, 38(2), 223–231.

By: B. Gilger n

MeSH headings : Adaptation, Physiological; Animals; Autoantigens / immunology; Eye Infections / immunology; Eye Infections / veterinary; Immunity, Innate; Receptors, Cell Surface / immunology; Receptors, Cell Surface / metabolism; Receptors, Immunologic / immunology; Receptors, Immunologic / metabolism; Toll-Like Receptors / immunology; Toll-Like Receptors / metabolism
topics (OpenAlex): Ocular Surface and Contact Lens; Immune Response and Inflammation; Ocular Infections and Treatments
TL;DR: Toll-like receptors are the link between the innate and adaptive immune response, and are likely key components of the response of ocular tissue to infectious organisms and in the initiation and perpetuation of autoimmune disease. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2008 journal article

Letter to the Editor

Veterinary Ophthalmology, 11(3), 207–207.

By: B. Gilger n, A. Clode n, T. Miller n & R. McMullen n

MeSH headings : Animals; Controlled Clinical Trials as Topic; Diagnostic Techniques, Ophthalmological / standards; Dog Diseases / diagnosis; Dogs; Evidence-Based Medicine; Glaucoma / diagnosis; Glaucoma / veterinary
topics (OpenAlex): Veterinary Medicine and Surgery; Circadian rhythm and melatonin; Veterinary Equine Medical Research
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2008 journal article

Multifocal Electroretinogram in Rhodopsin P347L Transgenic Pigs

Investigative Opthalmology & Visual Science, 49(5), 2208.

By: Y. Ng*, H. Chan*, P. Chu*, C. To*, B. Gilger*, R. Petters n, F. Wong*

MeSH headings : Aminobutyrates; Animals; Animals, Genetically Modified; Computers, Handheld; Disease Models, Animal; Electroretinography; Mutation; N-Methylaspartate / toxicity; Photoreceptor Cells, Vertebrate / physiology; Pipecolic Acids / toxicity; Retinal Bipolar Cells / physiology; Retinitis Pigmentosa / genetics; Retinitis Pigmentosa / physiopathology; Rhodopsin / genetics; Swine; Synapses / physiology; Synaptic Transmission / drug effects; Synaptic Transmission / physiology; Tetrodotoxin / toxicity; Vision, Ocular
topics (OpenAlex): Retinal Development and Disorders; Photoreceptor and optogenetics research; Neuroscience and Neural Engineering
TL;DR: In Tg retinas, ectopic synapses formed between cones and rod bipolar cells probably altered signal processing of the ON-bipolar cell pathway and signal processing in inner retinal neurons was also modified. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2008 journal article

Ocular distribution and toxicity of intravitreal injection of triamcinolone acetonide in normal equine eyes

Veterinary Ophthalmology, 11, 15–19.

By: N. Yi n, J. Davis n, J. Salmon n & B. Gilger n

author keywords: horses; intravitreal; pharmacokinetics; toxicity; triamcinolone acetonide
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacokinetics; Anti-Inflammatory Agents / toxicity; Aqueous Humor / chemistry; Chromatography, High Pressure Liquid / methods; Chromatography, High Pressure Liquid / veterinary; Dose-Response Relationship, Drug; Electroretinography / veterinary; Horses / blood; Horses / metabolism; Injections / adverse effects; Injections / veterinary; Retina / drug effects; Tissue Distribution; Triamcinolone Acetonide / pharmacokinetics; Triamcinolone Acetonide / toxicity; Vitreous Body / chemistry
topics (OpenAlex): Ocular Infections and Treatments; Diphtheria, Corynebacterium, and Tetanus; Retinal Diseases and Treatments
TL;DR: There was no evidence of overt toxicity from intravitreal TA in normal horses and a single intravItreal injection resulted in TA ocular levels for 21 days, however, the risk for bacterial infections with intrav itreal injection or anterior chamber aspirations in horses is high. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2008 journal article

Ocular toxicity and distribution of subconjunctival and intravitreal rapamycin in horses

Journal of Veterinary Pharmacology and Therapeutics, 31(6), 511–516.

By: L. Douglas n, N. Yi n, J. Davis n, J. Salmon n & B. Gilger n

MeSH headings : Animals; Anti-Bacterial Agents / adverse effects; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / therapeutic use; Chromatography, High Pressure Liquid; Dermatitis, Phototoxic; Horses; Sirolimus / adverse effects; Sirolimus / pharmacokinetics; Sirolimus / therapeutic use; Tissue Distribution; Uveitis / drug therapy; Uveitis / veterinary
topics (OpenAlex): Ocular Infections and Treatments; Intraocular Surgery and Lenses; Antibiotics Pharmacokinetics and Efficacy
TL;DR: Drug could be detected in both the aqueous and vitreous humor after intravitreal injection and no evidence of ocular toxicity was noted on ophthalmic examination or histopathology, suggesting a lack of RAPA phototoxicity. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2008 journal article

Porcine global flash multifocal electroretinogram: Possible mechanisms for the glaucomatous changes in contrast response function

Vision Research, 48(16), 1726–1734.

By: P. Chu*, H. Chan*, Y. Ng*, B. Brown*, A. Siu*, B. Beale n, B. Gilger n, F. Wong*

author keywords: multifocal electroretinogram; global flash; pig; contrast; adaptation
MeSH headings : Animals; Contrast Sensitivity / physiology; Electroretinography / methods; Glaucoma / physiopathology; Glaucoma / psychology; Photic Stimulation / methods; Retina / physiopathology; Sus scrofa
topics (OpenAlex): Retinal Development and Disorders; Glaucoma and retinal disorders; Retinal Diseases and Treatments
TL;DR: It is believed that the DC of the porcine global flash mfERG is mainly composed of contributions from photoreceptors, and ON- and OFF-bipolar cells, where inner retinal activity partially shaped the DC with superimposed regular wavelets. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2008 journal article

Role of bacteria in the pathogenesis of recurrent uveitis in horses from the southeastern United States

American Journal of Veterinary Research, 69(10), 1329–1335.

By: B. Gilger n, J. Salmon n, N. Yi n, C. Barden n, H. Chandler n, J. Wendt n, C. Colitz n

MeSH headings : Animals; Aqueous Humor / microbiology; Horse Diseases / microbiology; Horses; Leptospira / genetics; Leptospira / isolation & purification; Leptospirosis / microbiology; Leptospirosis / veterinary; Polymerase Chain Reaction; RNA, Ribosomal / genetics; Recurrence; Reference Values; Southeastern United States; Uveitis / microbiology; Uveitis / veterinary; Vitreous Body / microbiology
topics (OpenAlex): Leptospirosis research and findings; Vector-borne infectious diseases; Mycobacterium research and diagnosis
TL;DR: In horses from the southeastern United States, Leptospira organisms may have helped initiate ERU in some, but the continued presence of the organisms did not play a direct role in the pathogenesis of this recurrent disease. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2007 journal article

A Pharmacokinetic and Safety Evaluation of an Episcleral Cyclosporine Implant for Potential Use in High-Risk Keratoplasty Rejection

Investigative Opthalmology & Visual Science, 48(5), 2023.

By: S. Lee*, H. Kim*, N. Wang*, P. Bungay*, B. Gilger n, P. Yuan*, J. Kim*, K. Csaky*, M. Robinson*

MeSH headings : Animals; Aqueous Humor / metabolism; Biological Availability; Conjunctiva / metabolism; Cornea / metabolism; Cyclosporine / pharmacokinetics; Cyclosporine / toxicity; Dogs; Drug Implants; Eyelids / metabolism; Female; Graft Rejection / prevention & control; Immunosuppressive Agents / pharmacokinetics; Immunosuppressive Agents / toxicity; Keratoplasty, Penetrating; Lymph Nodes / metabolism; Male; Rabbits; Sclera / metabolism
topics (OpenAlex): Corneal Surgery and Treatments; Intraocular Surgery and Lenses; Corneal surgery and disorders
TL;DR: Episcleral implants are safe and effective at delivering therapeutic CsA levels to the cornea to potentially prevent corneal allograft rejection and assess the toxicity of a cyclosporine episcleral implant for the prevention of high-risk keratoplasty rejection. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2007 chapter

Corneal diseases and surgery

In K. N. Gelatt (Ed.), Veterinary Ophthalmology (4th ed.). Ames, Iowa: Blackwell Publishing.

By: B. Gilger

Ed(s): K. Gelatt

Source: NC State University Libraries
Added: October 20, 2020

2007 journal article

Pharmacologically defined components of the normal porcine multifocal ERG

Documenta Ophthalmologica, 116(3), 165–176.

By: Y. Ng*, H. Chan*, P. Chu*, A. Siu*, C. To*, B. Beale n, B. Gilger n, F. Wong*

author keywords: adaptation; multifocal electroretinography; nonlinearity; pig; retina
MeSH headings : Aminobutyrates / pharmacology; Anesthetics, Inhalation / administration & dosage; Animals; Electroretinography / drug effects; Excitatory Amino Acid Agonists / pharmacology; Excitatory Amino Acid Antagonists / pharmacology; Injections; N-Methylaspartate / pharmacology; Pipecolic Acids / pharmacology; Receptors, N-Methyl-D-Aspartate / physiology; Retina / physiology; Retinal Bipolar Cells / physiology; Sodium Channel Blockers / pharmacology; Sodium Channels / physiology; Swine; Tetrodotoxin / pharmacology; Vitreous Body
topics (OpenAlex): Retinal Development and Disorders; Photoreceptor and optogenetics research; Neuroscience and Neuropharmacology Research
TL;DR: Better understanding of the cellular origins of the normal porcine mfERG will be useful for comparing and defining the functional changes that may occur in diseased retinas. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2007 journal article

Proteinases of the cornea and preocular tear film

Veterinary Ophthalmology, 10(4), 199–206.

By: F. Ollivier*, B. Gilger n, K. Barrie*, M. Kallberg*, C. Plummer*, S. O?Reilly*, K. Gelatt*, D. Brooks*

author keywords: corneal ulceration; dog; horse; preocular tear film; proteinase inhibitors; proteinase
MeSH headings : Animals; Cats; Cornea / enzymology; Corneal Ulcer / enzymology; Corneal Ulcer / pathology; Corneal Ulcer / surgery; Corneal Ulcer / veterinary; Dogs; Horses; Matrix Metalloproteinases / metabolism; Tears / enzymology; Wound Healing
topics (OpenAlex): Protease and Inhibitor Mechanisms; Ocular Surface and Contact Lens; Corneal Surgery and Treatments
TL;DR: In animals, successful treatment leads to a rapid reduction in tear film proteolytic activity that corresponds with the improvement in the clinical signs of corneal ulceration, and a combination of these proteinase inhibitors may be beneficial. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2007 journal article

Retinal detachment in horses: 40 cases (1998–2005)

Veterinary Ophthalmology, 10(6), 380–385.

By: B. Strobel n, D. Wilkie* & B. Gilger n

author keywords: equine recurrent uveitis; equine; retinal detachment; trauma
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Diagnostic Techniques, Ophthalmological / veterinary; Female; Horse Diseases / diagnosis; Horse Diseases / drug therapy; Horse Diseases / epidemiology; Horse Diseases / etiology; Horses; Male; North Carolina / epidemiology; Ohio / epidemiology; Ophthalmic Solutions / administration & dosage; Ophthalmic Solutions / therapeutic use; Retinal Detachment / epidemiology; Retinal Detachment / veterinary; Retrospective Studies
topics (OpenAlex): Intraocular Surgery and Lenses; Traumatic Ocular and Foreign Body Injuries; Ocular Infections and Treatments
TL;DR: The visual prognosis of RD in horses is grave; however, horses with nontraumatic RD (most commonly ERU) may be able to maintain a comfortable but blind globe with anti-inflammatory medical therapy. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2006 journal article

A Novel Bioerodible Deep Scleral Lamellar Cyclosporine Implant for Uveitis

Investigative Opthalmology & Visual Science, 47(6), 2596.

By: B. Gilger n, J. Salmon n, D. Wilkie*, L. Cruysberg*, J. Kim*, M. Hayat*, H. Kim*, S. Kim* ...

MeSH headings : Absorbable Implants / veterinary; Animals; Cyclosporine / administration & dosage; Cyclosporine / adverse effects; Cyclosporine / pharmacokinetics; Drug Delivery Systems / veterinary; Feasibility Studies; Horse Diseases / drug therapy; Horse Diseases / metabolism; Horse Diseases / pathology; Horses; Humans; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / adverse effects; Immunosuppressive Agents / pharmacokinetics; Leptospira interrogans / drug effects; Leptospira interrogans / growth & development; Microbial Sensitivity Tests; Panuveitis / drug therapy; Panuveitis / metabolism; Panuveitis / pathology; Panuveitis / veterinary; Permeability; Recurrence; Sclera / metabolism; Treatment Outcome
topics (OpenAlex): Cytomegalovirus and herpesvirus research; Herpesvirus Infections and Treatments
TL;DR: Diffusion of CsA across the sclera from the episcleral space was not a feasible method of drug delivery to the equine eye, but placing a deep scleral lamellar C sA implant adjacent to the suprachoroidal space was effective in achieving therapeutic ocular drug concentrations and controlling uveitis in horses with ERU. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2006 journal article

Effect of ophthalmic Nd:YAG laser energy on intraocular lenses after posterior capsulotomy in normal dog eyes

Veterinary Ophthalmology, 9(5), 335–340.

By: A. Beale n, J. Salmon n, T. Michau n & B. Gilger n

author keywords: canine; Nd : YAG laser capsulotomy; posterior capsular opacity
MeSH headings : Acrylates; Animals; Dogs; Intraoperative Complications; Laser Therapy / adverse effects; Lens Capsule, Crystalline / surgery; Lenses, Intraocular; Models, Anatomic
topics (OpenAlex): Intraocular Surgery and Lenses; Traumatic Ocular and Foreign Body Injuries; Ocular Infections and Treatments
TL;DR: Both posterior lens capsules and Iols were disrupted in an energy-dependent manner with minimal difference in number of capsulotomy sites or damage to the IOL between acrylic and PMMA IOLs in normal canine cadaver eyes. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2006 journal article

Evaluation of concentration of voriconazole in aqueous humor after topical and oral administration in horses

American Journal of Veterinary Research, 67(2), 296–301.

By: A. Clode n, J. Davis*, J. Salmon*, T. Michau* & B. Gilger*

MeSH headings : Administration, Oral; Administration, Topical; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / adverse effects; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Aqueous Humor / chemistry; Dose-Response Relationship, Drug; Female; Horses / metabolism; Male; Pyrimidines / administration & dosage; Pyrimidines / adverse effects; Pyrimidines / blood; Pyrimidines / pharmacokinetics; Triazoles / administration & dosage; Triazoles / adverse effects; Triazoles / blood; Triazoles / pharmacokinetics; Voriconazole
topics (OpenAlex): Ocular Infections and Treatments; Antifungal resistance and susceptibility; Intraocular Surgery and Lenses
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2006 journal article

Keratometry, biometry and prediction of intraocular lens power in the equine eye

Veterinary Ophthalmology, 9(5), 357–360.

By: R. McMullen n & B. Gilger n

author keywords: biometry; equine; intraocular lens; keratometry
MeSH headings : Animals; Animals, Newborn; Biometry; Cataract / physiopathology; Cataract / veterinary; Cataract Extraction / veterinary; Cornea / anatomy & histology; Cornea / diagnostic imaging; Female; Horse Diseases / physiopathology; Horses; Lenses, Intraocular / veterinary; Male; Postoperative Period; Ultrasonography
topics (OpenAlex): Intraocular Surgery and Lenses; Veterinary Equine Medical Research; Corneal surgery and disorders
TL;DR: An IOL of substantially lower diopter strength than that needed in either dogs or cats is required to achieve emmetropia after lens extraction in adult horses. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2006 chapter

Surgical management of equine recurrent uveitis

In J. A. Auer & J. A. Stick (Eds.), Equine Surgery (3rd ed., pp. 749–755).

By: B. Gilger* & B. Spiess

Ed(s): J. Auer & J. Stick

topics (OpenAlex): Toxoplasma gondii Research Studies; Herpesvirus Infections and Treatments
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: October 20, 2020

2006 journal article

Sustained Release Cyclosporine Therapy for Bilateral Keratoconjunctivitis Sicca in a Red Wolf (Canis rufus)

Journal of Zoo and Wildlife Medicine, 37(4), 562–564.

By: A. Acton n, A. Beale, B. Gilger* & M. Stoskopf*

author keywords: Canis rufus; cyclosporine; dry eye; keratoconjuctivitis sicca (KCS); sustained-release delivery; red wolf
MeSH headings : Animals; Cyclosporine / therapeutic use; Drug Implants / therapeutic use; Immunosuppressive Agents / therapeutic use; Keratoconjunctivitis Sicca / drug therapy; Keratoconjunctivitis Sicca / veterinary; Male; Treatment Outcome; Wolves
topics (OpenAlex): Ocular Surface and Contact Lens; Ocular Infections and Treatments; Corneal Surgery and Treatments
TL;DR: A 12-yr-old intact male red wolf diagnosed with bilateral idiopathic dry eye was treated with subconjunctival drug delivery implants designed to release therapeutic levels of cyclosporine from 12–24 mo. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2005 journal article

Bilateral nodular lymphocytic conjunctivitis in a horse

Veterinary Ophthalmology, 8(2), 129–134.

By: R. Stoppini*, B. Gilger n, D. Malarkey*, A. Ratto* & G. Brigati

author keywords: conjunctival mass; horse; nodular lymphoid hyperplasia
MeSH headings : Animals; Conjunctival Neoplasms / diagnosis; Conjunctival Neoplasms / veterinary; Diagnosis, Differential; Horse Diseases / diagnosis; Horse Diseases / pathology; Horses; Immunohistochemistry / veterinary; Lymphoma, B-Cell, Marginal Zone / diagnosis; Lymphoma, B-Cell, Marginal Zone / veterinary; Male
topics (OpenAlex): Veterinary Oncology Research; T-cell and B-cell Immunology; Herpesvirus Infections and Treatments
TL;DR: This is the first reported case of bilateral nodular lymphocytic conjunctivitis in a horse and for which surgical excision alone was not curative. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2005 book

Equine Ophthalmology

Brian Gilger

Ed(s): B. Gilger

topics (OpenAlex): Intraocular Surgery and Lenses
TL;DR: The horse has a total visual field of nearly 360°, meaning a horse can just about see its tail with its head pointed forward, and Rods significantly outnumber cones, indicating the high capacity for night vision in horses, but cones are present in the horse retina with the capacity for color vision. (via Semantic Scholar)
Source: NC State University Libraries
Added: December 30, 2020

2005 article

Equine Recurrent Uveitis

Equine Ophthalmology, pp. 285–322.

By: A. Dwyer & B. Gilger*

topics (OpenAlex): Leptospirosis research and findings; Mycobacterium research and diagnosis; Bartonella species infections research
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: September 9, 2019

2005 chapter

Eyelid and adnexal diseases

In B. C. Gilger (Ed.), Equine Ophthalmology. Philadelphia, PA: Elsevier.

By: B. Gilger

Ed(s): B. Gilger

Source: NC State University Libraries
Added: February 24, 2024

2005 journal article

Immune-mediated keratitis in horses: 19 cases (1998-2004)

Veterinary Ophthalmology, 8(4), 233–239.

By: B. Gilger n, T. Michau n & J. Salmon n

author keywords: cornea; equine; immune-mediated diseases; keratitis
MeSH headings : Animals; Cyclosporine / administration & dosage; Dexamethasone / administration & dosage; Female; Horse Diseases / epidemiology; Horse Diseases / etiology; Horse Diseases / pathology; Horse Diseases / therapy; Horses; Immunosuppressive Agents / administration & dosage; Keratitis / epidemiology; Keratitis / veterinary; Male; North Carolina / epidemiology; Ophthalmic Solutions / administration & dosage; Ophthalmologic Surgical Procedures / veterinary; Records / veterinary; Retrospective Studies; Severity of Illness Index
topics (OpenAlex): Veterinary Equine Medical Research; Ocular Infections and Treatments; Essential Oils and Antimicrobial Activity
TL;DR: Clinical and histologic findings, treatment, and outcome of horses with suspected immune-mediated keratitis (IMMK) are described, with horses with superficial IMMK responding to topical medical therapy, but responded best to surgical removal of the lesion. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2005 journal article

Ocular parameters related to drug delivery in the canine and equine eye: aqueous and vitreous humor volume and scleral surface area and thickness

Veterinary Ophthalmology, 8(4), 265–269.

By: B. Gilger n, K. Reeves n & J. Salmon n

author keywords: aqueous; canine; drug delivery; equine; scleral thickness; vitreous
MeSH headings : Animals; Aqueous Humor; Dogs / anatomy & histology; Drug Delivery Systems / veterinary; Horses / anatomy & histology; Ophthalmic Solutions / administration & dosage; Reference Values; Sclera / anatomy & histology; Vitreous Body / anatomy & histology
topics (OpenAlex): Glaucoma and retinal disorders; Corneal surgery and disorders; Intraocular Surgery and Lenses
TL;DR: The UBM measurement method appeared to be most consistent and reproducible when compared to direct measurement techniques and associated with significantly thinner scleral tissue than with fresh ocular tissue. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2005 journal article

Preclinical Evaluation of a Novel Episcleral Cyclosporine Implant for Ocular Graft-Versus-Host Disease

Investigative Opthalmology & Visual Science, 46(2), 655.

By: H. Kim*, K. Csaky*, B. Gilger n, J. Dunn*, S. Lee*, M. Tremblay*, F. de Monasterio*, G. Tansey* ...

MeSH headings : Animals; Biological Availability; Cyclosporine / pharmacokinetics; Cyclosporine / pharmacology; Cyclosporine / toxicity; Dogs; Drug Evaluation, Preclinical; Drug Implants; Electroretinography / drug effects; Eye / metabolism; Eye / pathology; Female; Graft vs Host Disease / pathology; Graft vs Host Disease / prevention & control; Immunosuppressive Agents / pharmacokinetics; Immunosuppressive Agents / pharmacology; Immunosuppressive Agents / toxicity; Keratoconjunctivitis / drug therapy; Keratoconjunctivitis / pathology; Male; Rabbits; Retina / drug effects; Safety; Sclera / drug effects; Sclera / metabolism; Sclera / pathology
topics (OpenAlex): Corneal Surgery and Treatments; Ocular Disorders and Treatments; Ocular Surface and Contact Lens
TL;DR: The episcleral cyclosporine implant shows promise in reducing the morbidity associated with lacrimal gland graft-versus-host disease after allogeneic hematopoietic stem cell transplantation and may have potential in treating other ocular inflammatory diseases. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2005 journal article

Surgical Removal of Cataracts Due to Diplostomum Species in Gulf Sturgeon (Acipenser oxyrinchus desotoi)

Journal of Zoo and Wildlife Medicine, 36(3), 504–508.

By: R. Bakal*, B. Hickson, B. Gilger*, M. Levy*, J. Flowers* & L. Khoo

author keywords: Acipenser oxyrinchus desotoi; cataract surgery; Diplostomum sp.; fish; Gulf sturgeon; trematode
MeSH headings : Animals; Animals, Wild / parasitology; Animals, Wild / surgery; Cataract / etiology; Cataract / parasitology; Cataract Extraction / methods; Cataract Extraction / veterinary; Fish Diseases / parasitology; Fish Diseases / surgery; Fishes; Trematode Infections / complications; Trematode Infections / surgery; Trematode Infections / veterinary
topics (OpenAlex): Parasite Biology and Host Interactions; Malaria Research and Control; Leech Biology and Applications
TL;DR: This report is the first known report of surgical correction of cataracts in sturgeon species, and it also is theFirst known attempt to correct vision problems in fish being returned to the wild. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2004 journal article

Cosmetic globe surgery in the horse

Veterinary Clinics of North America: Equine Practice, 20(2), 467–484.

By: T. Michau n & B. Gilger n

MeSH headings : Animals; Blindness / prevention & control; Blindness / surgery; Blindness / veterinary; Contact Lenses / veterinary; Diagnostic Techniques, Ophthalmological / veterinary; Eye Diseases / surgery; Eye Diseases / veterinary; Eye, Artificial / veterinary; Horse Diseases / surgery; Horses; Pain / prevention & control; Pain / surgery; Pain / veterinary; Prostheses and Implants / veterinary; Surgery, Plastic / veterinary
topics (OpenAlex): Ocular Disorders and Treatments; Ocular Surface and Contact Lens; Intraocular Surgery and Lenses
TL;DR: Options available for improved cosmetic outcome in horses with ocular scars or requiring enucleation are addressed. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2004 journal article

Equine glaucoma

Veterinary Clinics of North America: Equine Practice, 20(2), 381–391.

By: D. Wilkie* & B. Gilger*

MeSH headings : Animals; Glaucoma / diagnosis; Glaucoma / surgery; Glaucoma / therapy; Glaucoma / veterinary; Horse Diseases / diagnosis; Horse Diseases / surgery; Horse Diseases / therapy; Horses; Intraocular Pressure; Ocular Hypertension / etiology; Ocular Hypertension / veterinary
topics (OpenAlex): Glaucoma and retinal disorders; Corneal surgery and disorders; Veterinary Equine Medical Research
TL;DR: Congenital equine glaucoma is associated with developmental abnormalities of the iridocorneal angle or, in many cases, with the more severe anterior segment dysgenesis. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2004 journal article

Equine recurrent uveitis: new methods of management

Veterinary Clinics of North America: Equine Practice, 20(2), 417–427.

By: B. Gilger n & T. Michau n

MeSH headings : Animals; Blindness / etiology; Blindness / veterinary; Horse Diseases / pathology; Horse Diseases / surgery; Horse Diseases / therapy; Horses; Recurrence; Uveitis / pathology; Uveitis / surgery; Uveitis / therapy; Uveitis / veterinary; Vitrectomy / veterinary
topics (OpenAlex): Toxoplasma gondii Research Studies; Brucella: diagnosis, epidemiology, treatment
TL;DR: Clinical features ofERU, the causes of ERU, and new management and treatment options for horses with ERU are highlighted. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2004 chapter

Laser Applications in Equine Ophthalmology

(K. Sullins, Ed.). Equine Laser Applications.

By: B. Gilger

Ed(s): K. Sullins

Source: NC State University Libraries
Added: October 20, 2020

2004 journal article

Novel approaches to ocular drug delivery

Current Opinion in Molecular Therapeutics, 6(2), 195–205.

By: J. Davis, B. Gilger & M. Robinson

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Bartonella vinsonii subspecies berkhoffi as a possible cause of anterior uveitis and choroiditis in a dog

VETERINARY OPHTHALMOLOGY, 6(4), 299–304.

By: T. Michau n, E. Breitschwerdt n, B. Gilger n & M. Davidson n

author keywords: anterior uveitis; Bartonella vinsonii; canine; choroiditis
MeSH headings : Animals; Bartonella / isolation & purification; Bartonella Infections / diagnosis; Bartonella Infections / veterinary; Choroiditis / diagnosis; Choroiditis / veterinary; Diagnosis, Differential; Dog Diseases / diagnosis; Dog Diseases / microbiology; Dog Diseases / pathology; Dogs; Female; Uveitis, Anterior / diagnosis; Uveitis, Anterior / veterinary
topics (OpenAlex): Bartonella species infections research; Rabies epidemiology and control; Viral Infections and Vectors
TL;DR: This is the first reported case of a possible association between uveitis, choroiditis and Bartonella infection in the dog, without clinical manifestations of other organ or tissue involvement. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 article

Equine Recurrent Uveitis

Current Therapy in Equine Medicine, pp. 468–473.

By: B. Gilger*

topics (OpenAlex): Leptospirosis research and findings; Mycobacterium research and diagnosis; Herpesvirus Infections and Treatments
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: September 9, 2019

2003 chapter

Equine Recurrent Uveitis

In N. R. Robinson (Ed.), Current Therapy in Equine Medicine (5th edition, pp. 468–473). Philadelphia, PA: Saunders.

By: B. Gilger

Ed(s): N. Robinson

Source: NC State University Libraries
Added: December 22, 2020

2003 journal article

Intraocular extramedullary plasmacytoma in a cat

VETERINARY OPHTHALMOLOGY, 6(2), 177–181.

By: T. Michau n, D. Proulx n, S. Rushton n, T. Olivry n, S. Dunston n, B. Gilger n, M. Davidson n

Contributors: T. Michau n, D. Proulx n, S. Rushton n, T. Olivry n, S. Dunston n, B. Gilger n, M. Davidson n

author keywords: extramedullary; feline; iris; neoplasia; plasmacytoma
MeSH headings : Animals; Antineoplastic Agents / therapeutic use; Blindness / etiology; Blindness / veterinary; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cat Diseases / pathology; Cats; Drug Therapy, Combination; Eye Injuries / complications; Eye Injuries / veterinary; Eye Neoplasms / complications; Eye Neoplasms / diagnosis; Eye Neoplasms / veterinary; Lymphatic Metastasis; Male; Melphalan / therapeutic use; Orbit Evisceration / veterinary; Plasmacytoma / complications; Plasmacytoma / diagnosis; Plasmacytoma / veterinary; Prednisone / therapeutic use
topics (OpenAlex): Platelet Disorders and Treatments; Autoimmune Bullous Skin Diseases; Multiple Myeloma Research and Treatments
TL;DR: An 8-year-old, castrated male Domestic Short-haired cat was referred for evaluation of a possible intraocular neoplasm following previous ocular trauma and enucleation revealed neoplastic proliferation of plasma cells in the iris and lymph node. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2003 journal article

Superficial, nonhealing corneal ulcers in horses: 23 cases (1989-2003)

VETERINARY OPHTHALMOLOGY, 6(4), 291–297.

By: T. Michau n, B. Schwabenton*, M. Davidson n & B. Gilger n

author keywords: cornea; equine; indolent; nonhealing; ulcer
MeSH headings : Animals; Corneal Ulcer / epidemiology; Corneal Ulcer / veterinary; Female; Horse Diseases / epidemiology; Horse Diseases / etiology; Horse Diseases / pathology; Horse Diseases / surgery; Horses; Male; North Carolina / epidemiology; Ophthalmologic Surgical Procedures / methods; Ophthalmologic Surgical Procedures / veterinary; Records / veterinary; Retrospective Studies; Surgery, Veterinary / methods; Wound Healing
topics (OpenAlex): Ocular Infections and Treatments; Plant Toxicity and Pharmacological Properties; Veterinary Equine Medical Research
TL;DR: Horses treated with a single debridement at initial evaluation healed in a significantly shorter time period than horses treated with grid keratotomy or superficial keratectomy, but the results of this study suggest that these procedures should only be performed following failure of the ulcer to heal after epithelial debridements. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

The effect of topical administration of atropine sulfate on the normal equine pupil: influence of age, breed and gender

VETERINARY OPHTHALMOLOGY, 6(4), 329–332.

By: J. Davis n, T. Stewart*, E. Brazik n & B. Gilger n

author keywords: atropine; equine; mydriasis
MeSH headings : Administration, Topical; Animals; Atropine / administration & dosage; Atropine / pharmacology; Female; Horses / physiology; Male; Mydriatics / administration & dosage; Mydriatics / pharmacology; Ophthalmic Solutions; Pedigree; Pupil / drug effects; Pupil / physiology
topics (OpenAlex): Plant Toxicity and Pharmacological Properties; Phytochemistry and Biological Activities; Veterinary Equine Medical Research
TL;DR: Horses of the Arabian breed and female horses may be more sensitive to effects of cholinergic blockade in the eye following a single dose of 1% atropine sulfate ophthalmic solution in the normal equine eye. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Transpupillary diode laser retinopexy in dogs: ophthalmoscopic, fluorescein angiographic and histopathologic study

VETERINARY OPHTHALMOLOGY, 6(3), 227–235.

By: S. Pizzirani n, A. Davidson n & B. Gilger n

author keywords: diode laser; dog; retinal detachment; retinopexy; tapetum
MeSH headings : Angiography / veterinary; Animals; Dogs; Dose-Response Relationship, Radiation; Female; Laser Coagulation / adverse effects; Laser Coagulation / veterinary; Microscopy / veterinary; Ophthalmoscopy / veterinary; Retina / pathology; Retina / radiation effects
topics (OpenAlex): Glaucoma and retinal disorders; Retinal and Macular Surgery; Intraocular Surgery and Lenses
TL;DR: The diode laser effectively produces lesions suitable for retinopexy in both the nontapetal, pigmented fundus and the tapetal fundus, although variably so in the latter region. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Use of a hydroxyapatite orbital implant in a cosmetic corneoscleral prosthesis after enucleation in a horse

JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 222(3), 343–345.

By: B. Gilger n, S. Pizzirani, L. Johnston & N. Urdiales

MeSH headings : Animals; Biocompatible Materials; Durapatite; Eye Enucleation / rehabilitation; Eye Enucleation / veterinary; Eye, Artificial / veterinary; Horses / surgery; Male; Orbit / surgery
topics (OpenAlex): Ocular Disorders and Treatments; Corneal Surgery and Treatments; Ocular Surface and Contact Lens
TL;DR: A hydroxyapatite orbital implant was used after enucleation of an eye from a 5-year-old performance horse and a custom-made corneoscleral prosthesis was made and fitted over the hydroxyAPatite implant. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Use of thermokeratoplasty for treatment of ulcerative keratitis and bullous keratopathy secondary to corneal endothelial disease in dogs: 13 cases (1994-2001)

JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 222(5), 607–612.

By: T. Michau n, B. Gilger*, F. Maggio* & M. Davidson*

MeSH headings : Animals; Corneal Dystrophies, Hereditary / surgery; Corneal Dystrophies, Hereditary / veterinary; Corneal Edema / surgery; Corneal Edema / veterinary; Corneal Transplantation / methods; Corneal Transplantation / veterinary; Corneal Ulcer / surgery; Corneal Ulcer / veterinary; Dog Diseases / surgery; Dogs; Endothelium, Corneal / pathology; Female; Male; Postoperative Complications / veterinary; Recurrence; Retrospective Studies; Treatment Outcome; Wound Healing
topics (OpenAlex): Wound Healing and Treatments; Corneal Surgery and Treatments; Tendon Structure and Treatment
TL;DR: It may be necessary to perform thermokeratoplasty of the entire cornea to prevent recurrence of ulcerations in areas that have not been treated with thermoker atoplasty. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Bilateral proliferative keratitis in a Domestic Long-haired cat

VETERINARY OPHTHALMOLOGY, 5(2), 137–140.

By: C. Colitz n, M. Davidson n & B. Gilger n

author keywords: cat; proliferative keratitis; feline herpesvirus-1
MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / pathology; Cat Diseases / virology; Cats; Diagnosis, Differential; Female; Herpesviridae / isolation & purification; Herpesviridae Infections / complications; Herpesviridae Infections / diagnosis; Herpesviridae Infections / veterinary; Keratitis / diagnosis; Keratitis / etiology; Keratitis / veterinary
topics (OpenAlex): Herpesvirus Infections and Treatments; Toxoplasma gondii Research Studies; Ocular Infections and Treatments
TL;DR: A 9-year-old, female spayed, Domestic Long-haired cat was presented with bilateral, progressive, pink-white corneal opacities andSouthern blot analysis for FHV-1 was positive, and the cat responded to topical corticosteroids and cyclosporine when used consistently. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Causes of uveitis in dogs: 102 cases (1989-2000)

VETERINARY OPHTHALMOLOGY, 5(2), 93–98.

By: K. Massa n, B. Gilger n, T. Miller n & M. Davidson n

author keywords: canine; etiology; retrospective; uveitis
MeSH headings : Animals; Breeding; Dog Diseases / diagnosis; Dog Diseases / epidemiology; Dog Diseases / etiology; Dogs; Ehrlichiosis / epidemiology; Ehrlichiosis / etiology; Ehrlichiosis / veterinary; Eye Neoplasms / epidemiology; Eye Neoplasms / etiology; Eye Neoplasms / veterinary; Female; Lymphoma, Non-Hodgkin / epidemiology; Lymphoma, Non-Hodgkin / etiology; Lymphoma, Non-Hodgkin / veterinary; Male; North Carolina / epidemiology; Records / veterinary; Retrospective Studies; Uveitis / epidemiology; Uveitis / etiology; Uveitis / veterinary; Uveitis, Suppurative / epidemiology; Uveitis, Suppurative / etiology; Uveitis, Suppurative / veterinary
topics (OpenAlex): Bartonella species infections research; Rabies epidemiology and control; Herpesvirus Infections and Treatments
TL;DR: Because of the high percentage of systemic disease associated with uveitis in dogs, extensive diagnostic testing is recommended before instituting symptomatic anti-inflammatory therapy. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Expression of a chemokine by ciliary body epithelium in horses with naturally occurring recurrent uveitis and in cultured ciliary body epithelial cells

AMERICAN JOURNAL OF VETERINARY RESEARCH, 63(7), 942–947.

By: B. Gilger n, P. Yang n, J. Salmon n, G. Jaffe n & J. Allen n

MeSH headings : Animals; Aqueous Humor / metabolism; Chemokine CCL5 / biosynthesis; Chemokine CCL5 / genetics; Chemotaxis; Ciliary Body / cytology; Ciliary Body / metabolism; Epithelial Cells / metabolism; Female; Horse Diseases / metabolism; Horses; Male; RNA / chemistry; RNA / genetics; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Sequence Analysis, DNA; Uveitis / metabolism; Uveitis / veterinary
topics (OpenAlex): Chemokine receptors and signaling; Immunotherapy and Immune Responses; T-cell and B-cell Immunology
TL;DR: Ciliary epithelium may play a role in recruitment and activation of leukocytes through expression of RANTES in horses by use of intradermal hypersensitivity testing and significant chemotaxis of equine leukocyte to rh-RANTES. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Nasal adenocarcinoma with diffuse metastases involving the orbit, cerebrum, and multiple cranial nerves in a horse

JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 221(10), 1460–1463.

By: J. Davis n, B. Gilger*, K. Spaulding*, I. Robertson* & S. Jones*

MeSH headings : Adenocarcinoma / diagnosis; Adenocarcinoma / secondary; Adenocarcinoma / veterinary; Animals; Brain Neoplasms / diagnosis; Brain Neoplasms / secondary; Brain Neoplasms / veterinary; Cerebrospinal Fluid / chemistry; Cranial Nerve Neoplasms / diagnosis; Cranial Nerve Neoplasms / secondary; Cranial Nerve Neoplasms / veterinary; Diagnosis, Differential; Fatal Outcome; Horse Diseases / diagnosis; Horse Diseases / pathology; Horses; Male; Nose Neoplasms / diagnosis; Nose Neoplasms / pathology; Nose Neoplasms / veterinary; Orbital Neoplasms / diagnosis; Orbital Neoplasms / secondary; Orbital Neoplasms / veterinary; Prognosis; Tomography, X-Ray Computed / veterinary
topics (OpenAlex): Veterinary Oncology Research; Infectious Diseases and Mycology; Salivary Gland Tumors Diagnosis and Treatment
TL;DR: A 9-year-old Trakehner gelding examined because of right exophthalmus found a lack of menace response in the right eye, reduced direct and consensual right pupillary light reflexes, ventrolateral strabismus of the rightEye, mild right-sided facial asymmetry, a head tilt to the left, and increased extensor tone in theright limbs. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2002 chapter

The lens

In D. Slatter (Ed.), Textbook of Veterinary Surgery (3rd ed.). WB Saunders.

By: B. Gilger

Ed(s): D. Slatter

Source: NC State University Libraries
Added: December 22, 2020

2001 journal article

Acute vision loss after general anesthesia in a cat

VETERINARY OPHTHALMOLOGY, 4(2), 155–158.

By: I. Jurk n, M. Thibodeau n, K. Whitney*, B. Gilger n & M. Davidson n

author keywords: anesthesia; blindness; cat; hypoxia
MeSH headings : Acute Disease; Anesthesia, General / adverse effects; Anesthesia, General / veterinary; Anesthetics, Inhalation / adverse effects; Animals; Blindness / chemically induced; Blindness / veterinary; Cat Diseases / chemically induced; Cats; Dental Prophylaxis / veterinary; Isoflurane / adverse effects; Male
topics (OpenAlex): Traumatic Brain Injury and Neurovascular Disturbances; Intraocular Surgery and Lenses; Neuroscience and Neuropharmacology Research
TL;DR: History and postmortem examination following euthanasia revealed cerebrocortical necrosis most consistent with anesthesia related hypoxia. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 chapter

Cherry eye

In P. Tilley & T. Smith (Eds.), The Five Minute Veterinary Consult (2nd ed., p. 969). Baltimore, MD: Williams & Wilkins.

By: B. Gilger

Ed(s): P. Tilley & T. Smith

Source: NC State University Libraries
Added: December 23, 2020

2001 chapter

Epiphora

In P. Tilley & T. Smith (Eds.), The Five Minute Veterinary Consult (2nd ed., pp. 62–63). Baltimore, MD: Williams & Wilkins.

By: B. Gilger

Ed(s): P. Tilley & T. Smith

Source: NC State University Libraries
Added: December 23, 2020

2001 chapter

Third eyelid, protruding

In P. Tilley & T. Smith (Eds.), The Five Minute Veterinary Consult (2nd ed., pp. 166–167). Baltimore, MD: Williams & Wilkins.

By: B. Gilger

Ed(s): P. Tilley & T. Smith

Source: NC State University Libraries
Added: December 23, 2020

2001 journal article

Use of an intravitreal sustained-release cyclosporine delivery device for treatment of equine recurrent uveitis

AMERICAN JOURNAL OF VETERINARY RESEARCH, 62(12), 1892–1896.

By: B. Gilger n, D. Wilkie n, M. Davidson n & J. Allen n

MeSH headings : Animals; Cyclosporine / administration & dosage; Delayed-Action Preparations; Electroretinography / veterinary; Female; Horse Diseases / drug therapy; Horse Diseases / immunology; Horses; Immunosuppressive Agents / administration & dosage; Male; Uveitis / drug therapy; Uveitis / immunology; Uveitis / veterinary
topics (OpenAlex): Signaling Pathways in Disease; Natural Compounds in Disease Treatment; Research on Leishmaniasis Studies
TL;DR: This intravitreal sustained-release CsA delivery device may be a safe and important tool for long-term treatment of horses with chronic recurrent uveitis. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 chapter

Canine conjunctivitis

In J. Bonagura (Ed.), Kirk's Veterinary Therapy XIII. Philadelphia: Lippincott Williams & Wilkins.

By: B. Gilger

Ed(s): J. Bonagura

Source: NC State University Libraries
Added: December 23, 2020

2000 journal article

Effect of an intravitreal cyclosporine implant on experimental uveitis in horses

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 76(3-4), 239–255.

By: B. Gilger n, E. Malok n, T. Stewart n, D. Horohov*, P. Ashton, T. Smith, G. Jaffe*, J. Allen n

author keywords: uveitis; cyclosporine; intravitreal; equine; experimental
MeSH headings : Animals; Aqueous Humor / drug effects; Aqueous Humor / immunology; Aqueous Humor / metabolism; Cyclosporine / administration & dosage; Cyclosporine / immunology; Cyclosporine / pharmacokinetics; Drug Implants; Horse Diseases / drug therapy; Horse Diseases / immunology; Horses; Immunohistochemistry / veterinary; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / immunology; Immunosuppressive Agents / pharmacokinetics; Interferon-gamma / biosynthesis; Interferon-gamma / metabolism; Interleukin-2 / biosynthesis; Interleukin-2 / metabolism; Lymphocyte Count / veterinary; RNA, Messenger / genetics; RNA, Messenger / metabolism; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction / veterinary; T-Lymphocytes / cytology; T-Lymphocytes / drug effects; Uveitis / drug therapy; Uveitis / immunology; Uveitis / veterinary
topics (OpenAlex): Cytomegalovirus and herpesvirus research; Mycobacterium research and diagnosis
TL;DR: CsA implants did not completely eliminate the development of a second ('recurrent') experimental inflammatory episode in these horses, but the duration and severity of inflammation, cellular infiltration, tissue destruction, and pro-inflammatory cytokines RNA transcript levels were significantly less in those eyes implanted with the CsA device. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Effect of single- and multiple-dose 0.5% timolol maleate on intraocular pressure and pupil size in female horses

Veterinary Ophthalmology, 3(2-3), 165–168.

By: A. Van Der Woerdt n, D. Wilkie, B. Gilger*, S. Strauch & S. Orczeck

topics (OpenAlex): Veterinary Equine Medical Research; Glaucoma and retinal disorders; Ocular Infections and Treatments
Sources: Crossref, NC State University Libraries
Added: September 9, 2019

2000 journal article

Long-term effect on the equine eye of an intravitreal device used for sustained release of cyclosporine A

Veterinary Ophthalmology, 3(2), 105.

By: B. Gilger n, E. Malok n, T. Stewart n, P. Ashton, T. Smith, G. Jaffe*, J. Allen n

topics (OpenAlex): Ocular Infections and Treatments; Intraocular Surgery and Lenses; Plant Toxicity and Pharmacological Properties
TL;DR: The CsA devices were well tolerated with no long-term complications from the implants themselves, however, complications may occur from inadvertent implantation trauma or contamination during surgery. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2000 article

Ocular lesions associated with systemic hypertension in cats: 69 cases (1985-1998)

Maggio, F., DeFrancesco, T. C., Atkins, C. E., Pizzirani, S., Gilger, B. C., & Davidson, M. G. (2000, September 1). JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 217, pp. 695–702.

MeSH headings : Animals; Blindness / etiology; Blindness / veterinary; Cat Diseases / etiology; Cat Diseases / pathology; Cats; Female; Fundus Oculi; Hypertension / complications; Hypertension / pathology; Hypertension / veterinary; Male; Retinal Diseases / etiology; Retinal Diseases / pathology; Retinal Diseases / veterinary; Retrospective Studies
topics (OpenAlex): Veterinary Medicine and Surgery; Cardiovascular Conditions and Treatments; Assisted Reproductive Technology and Twin Pregnancy
TL;DR: Retinal lesions, caused predominantly by choroidal injury, are common in cats with hypertension, and primary hypertension in cats may be more common than currently recognized. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 chapter

Ocular manifestations of systemic disease

In J. Bonagura (Ed.), Kirk's Veterinary Therapy XIII. Philadelphia: Lippincott Williams & Wilkins.

By: B. Gilger

Ed(s): J. Bonagura

Source: NC State University Libraries
Added: December 23, 2020

2000 journal article

Orbital fibroma in a horse

Veterinary Ophthalmology, 3(2-3), 213–216.

By: C. Colitz n, B. Gilger n, C. Davidson n & M. Ross

topics (OpenAlex): Veterinary Oncology Research; Veterinary Equine Medical Research; Soft tissue tumors and treatment
TL;DR: An 11-year-old American Quarterhorse gelding presented for moderate periorbital swelling and exophthalmia of the left eye and histopathologic evaluation was consistent with a fibroma, which has not recurred 14 months after surgery. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 9, 2019

1999 journal article

Acute renal failure in four cats treated with paromomycin

Journal of the American Veterinary Medical Association, 215(12), 1821–1823.

By: J. Gookin, J. Riviere, B. Gilger & M. Papich

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Angioinvasive pulmonary carcinoma with posterior segment metastasis in four cats

Veterinary Ophthalmology, 2(2), 125–131.

By: N. Cassotis n, R. Dubielzig*, B. Gilger n & M. Davidson n

topics (OpenAlex): Ocular Oncology and Treatments; Corneal Surgery and Treatments; Veterinary Oncology Research
TL;DR: Ischemic chorioretinopathy and necrosis of the distal extremities, associated with primary bronchogenic carcinoma, appear to be a unique neoplastic syndrome in the domestic cat. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 9, 2019

1999 journal article

Characterization of T-lymphocytes in the anterior uvea of eyes with chronic equine recurrent uveitis

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 71(1), 17–28.

By: B. Gilger n, E. Malok n, K. Cutter n, T. Stewart n, D. Horohov* & J. Allen n

author keywords: equine; uveitis; T-lymphocyte; cytokines; immunohistochemistry; QRT-PCR
MeSH headings : Animals; Chronic Disease; Ciliary Body / immunology; Ciliary Body / pathology; Cytokines / biosynthesis; Cytokines / genetics; Horse Diseases / immunology; Horse Diseases / pathology; Horses; Immunoenzyme Techniques / veterinary; Iris / immunology; Iris / pathology; RNA, Messenger / metabolism; Recurrence; Reverse Transcriptase Polymerase Chain Reaction / veterinary; T-Lymphocyte Subsets / immunology; T-Lymphocytes / immunology; Uveitis, Anterior / immunology; Uveitis, Anterior / pathology; Uveitis, Anterior / veterinary
topics (OpenAlex): Toxoplasma gondii Research Studies; melanin and skin pigmentation
TL;DR: The QRT-PCR results revealed increased transcription of IL-2 and IFNgamma and low IL-4 mRNA expression in eyes with chronic ERU compared to normal eyes, demonstrating a Thelper (Th) 1-like inflammatory response in Eyes with ERU. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 chapter

Diseases of the canine cornea and sclera

In K. N. Gelatt (Ed.), Veterinary Ophthalmology (3rd ed., pp. 635–673). Philadelphia: Lippincott Williams & Wilkins.

By: R. Whitley & B. Gilger

Ed(s): K. Gelatt

Source: NC State University Libraries
Added: December 23, 2020

1999 journal article

Efficacy of Doxycycline, Azithromycin, or Trovafloxacin for Treatment of Experimental Rocky Mountain Spotted Fever in Dogs

Antimicrobial Agents and Chemotherapy, 43(4), 813–821.

By: E. Breitschwerdt*, M. Papich n, B. Hegarty*, B. Gilger*, S. Hancock & M. Davidson*

MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / therapeutic use; Anti-Infective Agents / blood; Anti-Infective Agents / therapeutic use; Azithromycin / blood; Azithromycin / therapeutic use; Capillary Permeability / drug effects; DNA, Bacterial / analysis; Dogs; Doxycycline / blood; Doxycycline / therapeutic use; Female; Fluoroquinolones; Guinea Pigs; Male; Naphthyridines / blood; Naphthyridines / therapeutic use; Polymerase Chain Reaction; Rickettsia rickettsii / drug effects; Rickettsia rickettsii / isolation & purification; Rocky Mountain Spotted Fever / drug therapy; Rocky Mountain Spotted Fever / immunology; Treatment Outcome
topics (OpenAlex): Vector-borne infectious diseases; Mosquito-borne diseases and control; Viral Infections and Vectors
TL;DR: Doxycycline and trovafloxacin was as efficacious as doxycycline but azithromycin proved less efficacious, possibly due to the short duration of administration. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

1999 chapter

Food Animal Ocular Neoplasia.

In J. L. Howard & R. A. Smith (Eds.), Current Veterinary Therapy: Food Animal Practice (4th ed.). Philadelphia, W.B: Saunders, Inc.

By: C. Colitz & B. Gilger

Ed(s): J. Howard & R. Smith

Source: NC State University Libraries
Added: October 19, 2020

1999 journal article

Low-Dose Oral Administration of Interferon-alpha for the Treatment of Immune-Mediated Keratoconjunctivitis Sicca in Dogs

Journal of Interferon & Cytokine Research, 19(8), 901–905.

By: B. Gilger n, P. Rose, M. Davidson*, S. Roberts & T. Miller

MeSH headings : Administration, Oral; Animals; Dogs; Dose-Response Relationship, Drug; Female; Interferon-alpha / adverse effects; Interferon-alpha / therapeutic use; Keratoconjunctivitis Sicca / drug therapy; Keratoconjunctivitis Sicca / immunology; Keratoconjunctivitis Sicca / veterinary; Male; Treatment Outcome
topics (OpenAlex): Ocular Surface and Contact Lens; Corneal Surgery and Treatments; Ocular Infections and Treatments
TL;DR: Evaluated the effectiveness and dosage of oral use of interferon-alpha (IFN-alpha) in the treatment of naturally occurring, immune-mediated, canine keratoconjunctivitis sicca and found that dogs that responded did so with the 20 or 40 IU dose of IFN- alpha and tolerated the treatment well. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

1999 chapter

Surgery of the cornea and sclera

In K. N. Gelatt (Ed.), Veterinary Ophthalmology (3rd ed., pp. 675–700). Philadelphia: Lippincott Williams & Wilkins.

By: B. Gilger & R. Whitley

Ed(s): K. Gelatt

Source: NC State University Libraries
Added: December 23, 2020

1998 journal article

Cyclosporine A in Veterinary Ophthalmology

Veterinary Ophthalmology, 1(4), 181–187.

By: B. Gilger n & J. Allen n

topics (OpenAlex): Herpesvirus Infections and Treatments; Pediatric Hepatobiliary Diseases and Treatments; Testicular diseases and treatments
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

1998 journal article

Experimental implantation of posterior chamber prototype intraocular lenses for the feline eye

American Journal of Veterinary Research, 59(10), 1339–1343.

By: B. Gilger, M. Davidson & C. Colitz

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Keratometry, ultrasonic biometry, and prediction of intraocular lens power in the feline eye

American Journal of Veterinary Research, 59(2), 131–134.

By: B. Gilger, M. Davidson & P. Howard

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Normal variation in, and effect of 2% pilocarpine on, intraocular pressure and pupil size in female horses

American Journal of Veterinary Research, 59(11), 1459–1462.

By: A. van der Woerdt, B. Gilger, D. Wilkie, S. Strauch & S. Orczeck

Source: NC State University Libraries
Added: September 9, 2019

1998 journal article

Retinal degeneration associated with vitamin E deficiency in hunting dogs

Journal of the American Veterinary Medical Association, 213(5), 645–651.

By: M. Davidson, F. Geoly, B. Gilger, G. McLellan & W. Whitley

Source: NC State University Libraries
Added: August 6, 2018

1997 chapter

Cherry eye

In P. Tilley & T. Smith (Eds.), The Five Minute Veterinary Consult (p. 969). Baltimore, MD: Williams & Wilkins.

By: B. Gilger

Ed(s): P. Tilley & T. Smith

Source: NC State University Libraries
Added: December 23, 2020

1997 chapter

Epiphora

In P. Tilley & T. Smith (Eds.), The Five Minute Veterinary Consult (pp. 62–63). Baltimore, MD: Williams & Wilkins.

By: B. Gilger

Ed(s): P. Tilley & T. Smith

Source: NC State University Libraries
Added: December 23, 2020

1997 journal article

Neodymium:yttrium-aluminum-garnet laser treatment of cystic granula iridica in horses: Eight cases (1988–1996)

Journal of the American Veterinary Medical Association, 211(3), 341–343.

By: B. Gilger n, M. Davidson n, B. Nadelstein n & M. Nasisse n

topics (OpenAlex): Veterinary Equine Medical Research; Plant Toxicity and Pharmacological Properties; Entomological Studies and Ecology
TL;DR: Clinical signs associated with cysts resolved in all horses after treatment and treatment with an ophthalmic neodymium:yttrium-aluminum-garnet (Nd:YAG) laser appears to be safe and effective. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

1997 journal article

Phacoemulsification - Technology and fundamentals

VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 27(5), 1131-&.

By: B. Gilger n

MeSH headings : Animals; Dog Diseases / surgery; Dogs; Equipment Design; Phacoemulsification / instrumentation; Phacoemulsification / methods; Phacoemulsification / veterinary; Surgery, Veterinary / instrumentation; Surgery, Veterinary / methods
topics (OpenAlex): Intraocular Surgery and Lenses; Connexins and lens biology; Cerebral Venous Sinus Thrombosis
TL;DR: This chapter is designed to help the surgeon who is currently using phacoemulsification, or those who wish to understand more about technique, learn the basics and technology of the various types of phaco Emulsification machines. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

1997 journal article

Surgical treatment of dacryocystitis caused by cystic dilatation of the nasolacrimal system in three dogs

Journal of the American Veterinary Medical Association, 211(4), 445–447.

By: A. van der Woerdt, D. Wilkie, B. Gilger, D. Smeak & S. Kerpsack

Source: NC State University Libraries
Added: September 9, 2019

1997 chapter

Third eyelid, protruding

In P. Tilley & T. Smith (Eds.), The Five Minute Veterinary Consult (pp. 166–167). Baltimore, MD: Williams & Wilkins.

By: B. Gilger

Ed(s): P. Tilley & T. Smith

Source: NC State University Libraries
Added: December 23, 2020

1996 journal article

Eosinophilic keratoconjunctivitis in seven horses

Journal of the American Veterinary Medical Association, 209(7), 1283–1286.

By: M. Yamagata, D. Wilkie & B. Gilger

Source: NC State University Libraries
Added: September 9, 2019

1996 journal article

Lymphocyte proliferation and blood drug levels in dogs with keratoconjunctivitis sicca receiving long-term ocular cyclosporine

Veterinary & Comparative Ophthalmology, 6(2), 125–130.

By: B. Gilger, J. Andrews, D. Wilkie & M. Lairmore

Source: NC State University Libraries
Added: December 23, 2020

1996 journal article

Penetrating keratoplasty for treatment of recurrent squamous cell carcinoma of the cornea in a horse

Journal of the American Veterinary Medical Association, 208(10), 1692–1694.

By: A. van der Woerdt, B. Gilger & D. Wilkie

Source: NC State University Libraries
Added: September 9, 2019

1996 journal article

Pilot study on diode laser iridotomy in dogs

Veterinary & Comparative Ophthalmology, 6(4), 230–232.

By: B. Nadelstein, M. Davidson & B. Gilger

Source: NC State University Libraries
Added: December 23, 2020

1996 journal article

Ulcerative keratitis secondary to single layer repair of a traumatic eyelid laceration in a horse

Equine Practice, 18(10), 33–38.

By: A. Woerdt, D. Wilkie & B. Gilger

Source: NC State University Libraries
Added: December 23, 2020

1995 journal article

Cellular immunity in dogs with keratoconjunctivitis sicca before and after treatment with topical 2% cyclosporine

Veterinary Immunology and Immunopathology, 49(3), 199–208.

By: B. Gilger*, J. Andrews*, D. Wilkie*, M. Wyman* & M. Lairmore*

MeSH headings : Administration, Topical; Animals; CD4-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / immunology; Cyclosporine / therapeutic use; Dog Diseases / drug therapy; Dog Diseases / immunology; Dogs; Female; Immunity, Cellular; Immunosuppressive Agents / therapeutic use; Keratoconjunctivitis Sicca / drug therapy; Keratoconjunctivitis Sicca / immunology; Keratoconjunctivitis Sicca / veterinary; Lymphocyte Activation / immunology; Lymphocyte Count / veterinary; Male; Ophthalmic Solutions
topics (OpenAlex): Ocular Surface and Contact Lens; Corneal Surgery and Treatments; Herpesvirus Infections and Treatments
TL;DR: It is suggested that dogs with KCS may not have altered peripheral cellular immunity and that use of topical 2% cyclosporine for treatment of KCS causes a suppression of lymphocyte proliferation after 1 to 3 months of use. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 21, 2019

1995 journal article

Clinical evaluation of a new Schirmer tear test in the dog

Veterinary & Comparative Ophthalmology, 5(4), 211–214.

By: M. Wyman, B. Gilger, P. Mueller & K. Norris

Source: NC State University Libraries
Added: December 23, 2020

1995 journal article

Effect of auriculopalpebral nerve block and intravenous administration of xylazine on intraocular pressure and corneal thickness in horses

American Journal of Veterinary Research, 56(2), 155–158.

By: A. van der Woerdt, B. Gilger, D. Wilkie & S. Strauch

Source: NC State University Libraries
Added: September 9, 2019

1995 journal article

Intraocular silicone prosthesis implantation in eyes of dogs and a cat with intraocular neoplasia: nine cases (1983-1994)

Journal of the American Veterinary Medical Association, 207(11), 1441–1443.

By: S. McLaughlin, D. Ramsey, D. Lindley, B. Gilger, P. Gerding & R. Whitley

Source: NC State University Libraries
Added: September 9, 2019

1995 journal article

Traumatic ocular proptoses in dogs and cats: 84 cases (1980-1993)

Journal of the American Veterinary Medical Association, 206(8), 1186–1190.

By: B. Gilger, H. Hamilton, D. Wilkie, A. van der Woerdt, S. McLaughlin & R. Whitley

Source: NC State University Libraries
Added: October 6, 2019

1995 journal article

Update on eye disorders among purebred dogs

Veterinary Medicine, 96(6), 574–592.

By: R. Whitley, S. McLaughlin & B. Gilger

Source: NC State University Libraries
Added: February 24, 2024

1995 journal article

Uveal malignant melanoma in a duck

Journal of the American Veterinary Medical Association, 206(10), 1580–1582.

By: B. Gilger, S. McLaughlin & P. Smith

Source: NC State University Libraries
Added: September 9, 2019

1994 journal article

Concomitant brainstem axonal dystrophy and necrotizing myopathy in vitamin E-deficient rats

Journal of the Neurological Sciences, 123(1-2), 64–73.

By: S. Pillai*, M. Traber*, H. Kayden*, N. Cox*, M. Toivio-Kinnucan*, J. Wright*, K. Braund*, R. Whitley* ...

author keywords: ALPHA TOCOPHEROL; VITAMIN E-DEFICIENCY; NECROTIZING MYOPATHY; AXONAL DYSTROPHY; SPHEROIDS
MeSH headings : Adipose Tissue / metabolism; Animals; Axons / pathology; Brain Stem / pathology; Electromyography; Evoked Potentials; Evoked Potentials, Somatosensory; Male; Motor Neurons / physiology; Muscles / pathology; Necrosis; Neural Conduction / drug effects; Neural Conduction / physiology; Rats; Rats, Wistar; Reference Values; Sciatic Nerve / metabolism; Spinal Cord / metabolism; Time Factors; Vitamin E / metabolism; Vitamin E / pharmacology; Vitamin E Deficiency / metabolism; Vitamin E Deficiency / pathology; Vitamin E Deficiency / physiopathology
topics (OpenAlex): Antioxidant Activity and Oxidative Stress; Pesticide Exposure and Toxicity; Vitamin C and Antioxidants Research
TL;DR: It is confirmed that low alpha-T concentrations in tissues precede histologic changes in peripheral nerves and skeletal muscle, and pathologic changes associated with vitamin E deficiency occur independently in muscle and nervous tissue of rats. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019

1994 journal article

Current concepts in feline ophthalmology II. diseases of the orbit, eyelids, third eyelid, and lacrimal system

Veterinary Medicine, 92, 12–18.

By: R. Whitley, B. Gilger, E. Whitley & S. McLaughlin

Source: NC State University Libraries
Added: February 24, 2024

1994 journal article

Die anwendung der phakofragmentation und aspiration sowie der introcularlinsenimplantation in der veterinarmedizinischen kataraktchirurgie

Kleintierpraxis, 39, 631–645.

By: B. Gilger, D. Wilkie, A. Woerdt & U. Granitz

Source: NC State University Libraries
Added: December 23, 2020

1994 journal article

Erfahrugen mit der implantation von intraokulären silikonprosthesen

Kleintierpraxis, 39, 300–305.

By: B. Gilger, D. Wilkie, A. Woerdt & U. Gränitz

Source: NC State University Libraries
Added: December 23, 2020

1994 journal article

Histological findings in corneal stromal abscesses of 11 horses: correlation with cultures and cytology

Equine Veterinary Journal, 26(6), 448–453.

By: H. Hamilton*, S. McLaughlin*, E. Whitley*, B. Gilger* & R. Whitley*

author keywords: HORSE; CORNEA; STROMAL ABSCESS; MYCOTIC KERATITIS
MeSH headings : Abscess / microbiology; Abscess / pathology; Abscess / veterinary; Animals; Corneal Stroma / microbiology; Corneal Stroma / pathology; Female; Gram-Positive Cocci / isolation & purification; Horse Diseases / microbiology; Horse Diseases / pathology; Horses; Keratitis / microbiology; Keratitis / pathology; Keratitis / veterinary; Male; Mitosporic Fungi / isolation & purification; Retrospective Studies
topics (OpenAlex): Ocular Infections and Treatments; Infectious Diseases and Mycology; Antifungal resistance and susceptibility
TL;DR: Failure to detect bacterial growth may not rule out infection because anaerobic or intracellular bacteria would not be isolated and there is often destruction of bacteria by neutrophils, macrophages and antibiotic therapy greatly reducing their numbers. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2019

1994 journal article

Modified Lateral Orbitotomy for Removal of Orbital Neoplasms in Two Dogs

Veterinary Surgery, 23(1), 53–58.

By: B. Gilger*, R. Whitley* & S. Mclaughlin*

MeSH headings : Adenoma / surgery; Adenoma / veterinary; Animals; Dog Diseases / surgery; Dogs; Eyelid Neoplasms / surgery; Eyelid Neoplasms / veterinary; Female; Fibrosarcoma / secondary; Fibrosarcoma / surgery; Fibrosarcoma / veterinary; Lung Neoplasms / secondary; Lung Neoplasms / veterinary; Male; Orbit / surgery; Orbital Neoplasms / surgery; Orbital Neoplasms / veterinary; Zygoma / surgery
topics (OpenAlex): Veterinary Oncology Research; Ocular Oncology and Treatments; Cancer and Skin Lesions
TL;DR: The use of this technique for surgical excision of orbital masses in two dogs, one with a adenoma of the third eyelid gland and one with an orbital fibrosarcoma, and their subsequent management is described. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019

1993 journal article

Clinicopathologic findings after experimental implantation of synthetic intraocular lenses in dogs

American Journal of Veterinary Research, 54(4), 616–621.

By: B. Gilger, R. Whitley, S. McLaughlin, J. Wright & T. Boosinger

Source: NC State University Libraries
Added: September 9, 2019

1993 journal article

Corneal thickness measured by ultrasonic pachymetry in cats

American Journal of Veterinary Research, 54(2), 228–230.

By: B. Gilger, J. Wright, R. Whitley & S. McLaughlin

Source: NC State University Libraries
Added: September 9, 2019

1993 journal article

Current techniques in cataract surgery

Veterinary Medicine, 88(9), 859–865.

By: R. Whitley, B. Gilger & S. McLaughlin

Source: NC State University Libraries
Added: February 24, 2024

1993 journal article

Eyelid neoplasms in cats: A review of demographic data (1979-1989)

Journal of the American Animal Hospital Association, 29(1), 63–67.

By: S. McLaughlin, R. Whitley, B. Gilger, J. Wright & D. Lindley

Source: NC State University Libraries
Added: December 23, 2020

1993 journal article

Glaucoma and corneal stromal abscess in a horse treated by an intraocular silicone prosthesis and a conjunctival pedicle flap

Equine Practice, 15(6), 10–15.

By: B. Gilger & S. McLaughlin

Source: NC State University Libraries
Added: December 23, 2020

1993 journal article

Scanning electron microscopy of intraocular lenses that had been implanted in dogs

American Journal of Veterinary Research, 54(7), 1183–1187.

By: B. Gilger, R. Whitley, S. McLaughlin, J. Wright & T. Boosinger

Source: NC State University Libraries
Added: September 9, 2019

1992 journal article

Bilateral episcleral prolapse of orbital fat in a bull

Agri-Practice, 13(10), 18–23.

By: B. Gilger, D. Pugh & S. McLaughlin

Source: NC State University Libraries
Added: December 23, 2020

1992 journal article

Diagnosis and Treatment of Lens Diseases

Veterinary Clinics of North America: Equine Practice, 8(3), 575–585.

By: S. McLaughlin*, R. Whitley* & B. Gilger*

MeSH headings : Animals; Cataract / congenital; Cataract / diagnosis; Cataract / veterinary; Cataract Extraction / veterinary; Horse Diseases / congenital; Horse Diseases / diagnosis; Horse Diseases / surgery; Horses; Lens Diseases / congenital; Lens Diseases / diagnosis; Lens Diseases / surgery; Lens Diseases / veterinary
topics (OpenAlex): Plant Toxicity and Pharmacological Properties; Intraocular Surgery and Lenses; Veterinary Equine Medical Research
TL;DR: Veterinarians should consult with those versed in ophthalmology for assistance in diagnosis, prognosis, peroperative treatment, surgical intervention, and follow-up on lens disorders. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: July 27, 2019

1992 journal article

Infectious keratitis in horses: evaluation and management

The Compendium on Continuing Education for the Practicing Veterinarian, 14(3), 372–380.

By: S. McLaughlin, B. Gilger & R. Whitley

Source: NC State University Libraries
Added: December 23, 2020

1992 journal article

Orbital neoplasms in cats: 21 cases (1974-1990)

Journal of the American Veterinary Medical Association, 201(7), 1083–1086.

By: B. Gilger, S. McLaughlin, R. Whitley & J. Wright

Source: NC State University Libraries
Added: October 6, 2019

1991 chapter

Bovine ocular squamous cell carcinoma: a review

In C. S. G. Grunsell & M. E. Raw (Eds.), Veterinary Annual (Vol. 31, pp. 73–84). London: Blackwell Scientific Publications.

By: B. Gilger, R. Whitley & S. McLaughlin

Ed(s): C. Grunsell & M. Raw

Source: NC State University Libraries
Added: February 6, 2021

1991 journal article

Canine corneal thickness measured by ultrasonic pachymetry

American Journal of Veterinary Research, 52(10), 1570–1572.

By: B. Gilger, R. Whitley, S. McLaughlin, J. Wright & J. Drane

Source: NC State University Libraries
Added: September 9, 2019

1991 journal article

Ophthalmic atropine in horses: is colic a serious problem?

Equine Veterinary Education, 3(2), 94–96.

By: S. McLAUGHLIN*, R. Whitley* & B. Gilger*

topics (OpenAlex): Ocular Infections and Treatments; Essential Oils and Antimicrobial Activity; Plant Toxicity and Pharmacological Properties
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

1991 journal article

The treatments for keratoconjunctivitis sicca

Veterinary Medicine, (11), 1076–1093.

By: R. Whitley, S. McLaughlin, B. Gilger & D. Lindley

Source: NC State University Libraries
Added: February 24, 2024

journal article

Characterization of a quantitative model of corneal inflammation, wound healing, and fibrosis in the rabbit

Culp, D., Schaefer, E., Spiga, M. G., Hackney, A., Smith, N., & Gilger, B. C. Investigative Ophthalmology and Visual Science, 57(12).

By: D. Culp, E. Schaefer, M. Spiga, A. Hackney, N. Smith & B. Gilger

Source: NC State University Libraries
Added: August 6, 2018

chapter

Diagnosis and treatment of canine conjunctivitis

Gilger, B. C. In Kirk's current veterinary therapy : small animal practice (13th Ed.) (p. 1053). Philadelphia, PA : W.B. Saunders.

By: B. Gilger

Source: NC State University Libraries
Added: August 6, 2018

book

Equine ophthalmology

Gilger, B. C. Edinburgh; St. Louis, Mo.: Elsevier Saunders.

By: B. Gilger

Source: NC State University Libraries
Added: August 6, 2018

book

Equine ophthalmology

Gilger, B. C. St Louis, Mo: Elsevier Saunders.

By: B. Gilger

Source: NC State University Libraries
Added: August 6, 2018

journal article

GB-102 for wet AMD: a novel injectable formulation that safely delivers active levels of sunitinib to the retina and RPE/choroid for over four months

Yang, M., Peterson, W. M., Yu, Y., Kays, J., Cardona, D., Culp, D., … Cleland, J. Investigative Ophthalmology and Visual Science, 57(12).

By: M. Yang, W. Peterson, Y. Yu, J. Kays, D. Cardona, D. Culp, B. Gilger, J. Cleland

Source: NC State University Libraries
Added: August 6, 2018

journal article

Impact of fungal species cultured on outcome in horses with fungal keratitis

Sherman, A. B., Clode, A. B., & Gilger, B. C. Pferdeheilkunde, 33(4), 394–395.

By: A. Sherman, A. Clode & B. Gilger

Source: NC State University Libraries
Added: August 6, 2018

chapter

Ocular manifestations of systemic infectious diseases

Gilger, B. C. In Kirk's current veterinary therapy : small animal practice (13th Ed.) (p. 276). Philadelphia, PA : W.B. Saunders.

By: B. Gilger

Source: NC State University Libraries
Added: August 6, 2018

journal article

Ocular therapeutics: a practical guide

Gilger, B. C. North American Veterinary Conference. Veterinary Proceedings, 12(1998), 457–458.

By: B. Gilger

Source: NC State University Libraries
Added: August 6, 2018

journal article

Ophthalmic drug delivery systems for the treatment of retinal diseases: Basic research to clinical applications

Edelhauser, H. F., Rowe-Rendleman, C. L., Robinson, M. R., Dawson, D. G., Chader, G. J., Grossniklaus, H. E., … Holers, V. M. Investigative Ophthalmology and Visual Science, 51(11), 5403–5420.

By: H. Edelhauser, C. Rowe-Rendleman, M. Robinson, D. Dawson, G. Chader, H. Grossniklaus, K. Rittenhouse, C. Wilson ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Treatment of immune-mediated keratitis in horses with episcleral cyclosporine-silicone matrix- implant

Gilger, B. C., Stoppini, R., Wilkie, D. A., Clode, A. B., Pinto, N. H., Hempstead, J., … Salmon, J. H. Pferdeheilkunde, 30(6), 711–712.

By: B. Gilger, R. Stoppini, D. Wilkie, A. Clode, N. Pinto, J. Hempstead, J. Gerding, J. Salmon

Source: NC State University Libraries
Added: August 6, 2018

Employment

Updated: August 28th, 2019 07:27

1995 - present

North Carolina State University Raleigh, North Carolina, US
Professor of Ophthalmology Clinical Sciences

Education

Updated: August 28th, 2019 07:29

1988 - 1992

Auburn University Auburn, Alabama, US
MS

1984 - 1987

The Ohio State University Columbus, Ohio, US
DVM

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2025) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.