@article{hedgespeth_snider_bitting_cruse_2023, title={The exon-skipping oligonucleotide, KitStop, depletes tissue-resident mast cells in vivo to ameliorate anaphylaxis}, volume={14}, ISSN={["1664-3224"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-85148252370&partnerID=MN8TOARS}, DOI={10.3389/fimmu.2023.1006741}, abstractNote={IntroductionAnaphylaxis represents the most extreme and life-threatening form of allergic disease and is considered a medical emergency requiring immediate intervention. Additionally, some people with mastocytosis experience recurrent episodes of anaphylaxis during normal daily activities without exposure to known triggers. While acute therapy consists primarily of epinephrine and supportive care, chronic therapy relies mostly on desensitization and immunotherapy against the offending allergen, which is a time-consuming and sometimes unsuccessful process. These treatments also necessitate identification of the triggering allergen which is not always possible, and thus highlighting a need for alternative treatments for mast cell-mediated diseases.}, journal={FRONTIERS IN IMMUNOLOGY}, author={Hedgespeth, Barry A. A. and Snider, Douglas B. and Bitting, Katie J. and Cruse, Glenn}, year={2023}, month={Jan} }
 @article{bitting_hedgespeth_ehrhardt-humbert_arthur_schubert_bradding_tilley_cruse_2022, title={Identification of redundancy between human Fc epsilon RI beta and MS4A6A proteins points toward additional complex mechanisms for Fc epsilon RI trafficking and signaling}, volume={12}, ISSN={["1398-9995"]}, url={https://doi.org/10.1111/all.15595}, DOI={10.1111/all.15595}, abstractNote={Abstract}, number={5}, journal={ALLERGY}, author={Bitting, Katie and Hedgespeth, Barry and Ehrhardt-Humbert, Lauren C. and Arthur, Greer K. and Schubert, Alicia G. and Bradding, Peter and Tilley, Stephen L. and Cruse, Glenn}, year={2022}, month={Dec} }
 @article{hedgespeth_birkenheuer_friedenberg_olby_meurs_2021, title={A novel missense mutation of the NAT10 gene in a juvenile Schnauzer dog with chronic respiratory tract infections}, volume={35}, ISSN={["1939-1676"]}, url={https://doi.org/10.1111/jvim.16100}, DOI={10.1111/jvim.16100}, abstractNote={Abstract}, number={3}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Hedgespeth, Barry A. and Birkenheuer, Adam J. and Friedenberg, Steven G. and Olby, Natasha J. and Meurs, Kathryn M.}, year={2021}, month={May}, pages={1542–1546} }
 @article{bierlein_hedgespeth_azcarate-peril_stauffer_gookin_2021, title={Dysbiosis of fecal microbiota in cats with naturally occurring and experimentally induced Tritrichomonas foetus infection}, volume={16}, ISSN={["1932-6203"]}, DOI={10.1371/journal.pone.0246957}, abstractNote={The protozoal pathogen Tritrichomonas foetus infects the colon of domestic cats and is a major cause of chronic colitis and diarrhea. Treatment failure is common, but antibiotics may improve clinical signs in a subset of cats, leading researchers to question involvement of the colonic microbiota in disease pathogenesis. Studies performed in women with venereal Trichomonas vaginalis infections have revealed that dysbiosis of host microbiota contributes to pathogenicity with similar findings also found in mice with intestinal Tritrichomonas musculis The aim of this study was to characterize differences in the fecal microbiota of cats with and without naturally occurring T. foetus infection and in a group of kittens prior to and after experimentally induced infection. Archived fecal DNA from cats undergoing testing for T. foetus infection (n = 89) and experimentally infected kittens (n = 4; at pre-, 2 weeks, and 9 weeks post-infection) were analyzed by sequencing of 16S rRNA genes. Amongst the naturally infected population, the genera Megamonas and Helicobacter were significantly increased in prevalence and abundance in cats testing positive for T. foetus infection. In the group of four experimentally infected kittens, fecal samples post-infection had significantly lower abundance of genus Dialister and Megamonas and greater abundance of the class Betaproteobacteria and family Succinivibrionaceae. We hypothesize that T. foetus promotes dysbiosis by competition for fermentable substrates used by these bacteria and that metabolic byproducts may contribute to the pathogenesis of colonic inflammation and diarrhea. Future studies are warranted for the measurement of fecal concentrations of microbial and protozoal metabolites in cats with T. foetus infection for the identification of potential therapeutic targets.}, number={2}, journal={PLOS ONE}, author={Bierlein, Metzere and Hedgespeth, Barry A. and Azcarate-Peril, M. Andrea and Stauffer, Stephen H. and Gookin, Jody L.}, year={2021}, month={Feb} }
 @article{kong_bennett_jania_chason_german_adouli_budney_oby_heusden_lazarowski_et al._2021, title={Identification of an ATP/P2X7/mast cell pathway mediating ozone-induced bronchial hyperresponsiveness}, volume={6}, ISSN={["2379-3708"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-85118886921&partnerID=MN8TOARS}, DOI={10.1172/jci.insight.140207}, abstractNote={Ozone is a highly reactive environmental pollutant with well-recognized adverse effects on lung health. Bronchial hyperresponsiveness (BHR) is one consequence of ozone exposure, particularly for individuals with underlying lung disease. Our data demonstrated that ozone induced substantial ATP release from human airway epithelia in vitro and into the airways of mice in vivo and that ATP served as a potent inducer of mast cell degranulation and BHR, acting through P2X7 receptors on mast cells. Both mast cell–deficient and P2X7 receptor–deficient (P2X7–/–) mice demonstrated markedly attenuated BHR to ozone. Reconstitution of mast cell–deficient mice with WT mast cells and P2X7–/– mast cells restored ozone-induced BHR. Despite equal numbers of mast cells in reconstituted mouse lungs, mice reconstituted with P2X7–/– mast cells demonstrated significantly less robust BHR than mice reconstituted with WT mast cells. These results support a model where P2X7 on mast cells and other cell types contribute to ozone-induced BHR.}, number={21}, journal={JCI INSIGHT}, author={Kong, Xiaomei and Bennett, William C. and Jania, Corey M. and Chason, Kelly D. and German, Zachary and Adouli, Jennifer and Budney, Samuel D. and Oby, Brandon T. and Heusden, Catharina and Lazarowski, Eduardo R. and et al.}, year={2021}, month={Nov} }
 @article{hedgespeth_stauffer_robertson_gookin_2020, title={Association of fecal sample collection technique and treatment history with Tritrichomonas foetus polymerase chain reaction test results in 1717 cats}, volume={34}, ISSN={["1939-1676"]}, url={http://dx.doi.org/10.1111/jvim.15727}, DOI={10.1111/jvim.15727}, abstractNote={Abstract}, number={2}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Hedgespeth, Barry A. and Stauffer, Stephen H. and Robertson, James B. and Gookin, Jody L.}, year={2020}, month={Mar}, pages={734–741} }