Works (62)

Updated: August 26th, 2023 21:20

2018 journal article

Evaluation of cell culture-grown Bartonella antigens in immunofluorescent antibody assays for the serological diagnosis of bartonellosis in dogs

Journal of Veterinary Internal Medicine, 32(6), 1958–1964.

By: P. Neupane n, B. Hegarty n, H. Marr n, R. Maggi n, A. Birkenheuer n & E. Breitschwerdt n

author keywords: bacteria; BAPGM; serology; vector-borne; zoonosis
MeSH headings : Animals; Antigens, Bacterial / immunology; Bartonella / immunology; Bartonella Infections / diagnosis; Bartonella Infections / veterinary; Bartonella henselae / immunology; Bartonella quintana / immunology; Cells, Cultured; Dog Diseases / diagnosis; Dog Diseases / microbiology; Dogs; Fluorescent Antibody Technique / methods; Fluorescent Antibody Technique / veterinary; Polymerase Chain Reaction / veterinary; Sensitivity and Specificity; Serologic Tests / methods; Serologic Tests / veterinary; Trench Fever / diagnosis; Trench Fever / veterinary
TL;DR: Despite IFA testing of dogs against 8 different Bartonella isolates, IFA sensitivity remained poor, and specificity was only 85%. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: December 31, 2018

2015 journal article

Potentially Novel Ehrlichia Species in Horses, Nicaragua

Emerging Infectious Diseases, 21(2), 335–338.

By: V. O’Nion n, H. Montilla n, B. Qurollo n, R. Maggi n, B. Hegarty n, S. Tornquist n, E. Breitschwerdt n

MeSH headings : Animals; Ehrlichia / classification; Ehrlichia / genetics; Ehrlichiosis / veterinary; Horse Diseases / epidemiology; Horse Diseases / microbiology; Horses; Molecular Typing; Nicaragua / epidemiology; Phylogeny; RNA, Ribosomal, 16S / genetics; Serotyping
TL;DR: Sequencing of 16S rDNA, sodB, and groEL genes indicated that the bacterium is most likely a novel Ehrlichia species and the potential for canine and human infection remain unknown. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

Serological and molecular analysis of feline vector-borne anaplasmosis and ehrlichiosis using species-specific peptides and PCR

Parasites & Vectors, 8(1), 320.

By: B. Hegarty n, B. Qurollo n, B. Thomas n, K. Park n, R. Chandrashekar*, M. Beall*, B. Thatcher*, E. Breitschwerdt n

author keywords: Anaplasma; Borrelia; Ehrlichia; Cats; Vector-borne pathogens
MeSH headings : Anaplasma / genetics; Anaplasma / immunology; Anaplasma / isolation & purification; Anaplasmosis / blood; Anaplasmosis / diagnosis; Anaplasmosis / microbiology; Animals; Antibodies, Bacterial / blood; Cat Diseases / blood; Cat Diseases / diagnosis; Cat Diseases / microbiology; Cats; Ehrlichia / genetics; Ehrlichia / immunology; Ehrlichia / isolation & purification; Ehrlichiosis / blood; Ehrlichiosis / diagnosis; Ehrlichiosis / microbiology; Ehrlichiosis / veterinary; Female; Male; Peptides / genetics; Polymerase Chain Reaction; Prospective Studies; Species Specificity
TL;DR: This study provides the first evidence for E.chaffeensis and E.ewingii infection in naturally-exposed cats in North America and supports the need for regional, serological and molecular FVBP prevalence studies, and the need to further optimize serodiagnostic and PCR testing for cats. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Case Report: Molecular Evidence of Anaplasma platys Infection in Two Women from Venezuela

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 91(6), 1161–1165.

By: C. Arraga-Alvarado n, B. Qurollo n, O. Parra n, M. Berrueta n, B. Hegarty n & E. Breitschwerdt n

MeSH headings : Adult; Anaplasma / genetics; Anaplasmosis / diagnosis; Base Sequence; DNA Primers; DNA, Bacterial / genetics; Female; Humans; Middle Aged; Polymerase Chain Reaction; Venezuela
TL;DR: Two case reports of Anaplasma platys detection in two women from Venezuela are presented, providing further support for A. platys as a zoonotic tick-borne pathogen, most likely of low pathogenicity. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Intraoperative Bleeding in Dogs from Grenada Seroreactive to Anaplasma platys and Ehrlichia canis

Journal of Veterinary Internal Medicine, 28(6), 1702–1707.

By: M. Lanza-Perea*, U. Zieger*, B. Qurollo n, B. Hegarty n, E. Pultorak n, S. Kumthekar*, R. Bruhl-Day*, E. Breitschwerdt n

author keywords: Hemostasis; Infection; Rickettsia; Ticks
MeSH headings : Anaplasma; Anaplasmosis / blood; Anaplasmosis / complications; Anaplasmosis / epidemiology; Animals; Blood Loss, Surgical / veterinary; Dog Diseases / blood; Dog Diseases / epidemiology; Dog Diseases / etiology; Dog Diseases / microbiology; Dogs; Ehrlichia canis; Ehrlichiosis / blood; Ehrlichiosis / complications; Ehrlichiosis / epidemiology; Ehrlichiosis / veterinary; Female; Grenada / epidemiology; Male; Partial Thromboplastin Time / veterinary; Platelet Count / veterinary; Prothrombin Time / veterinary
TL;DR: Bleeding scores in dogs coseroreactive for A. platys and E. canis may have increased intraoperative bleeding tendencies despite normal hemostatic parameters, and improved tick control is needed for dogs in Grenada. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Intravascular persistence of Anaplasma platys, Ehrlichia chaffeensis, and Ehrlichia ewingii DNA in the blood of a dog and two family members

Parasites & Vectors, 7(1), 298.

author keywords: Anaplasma; Ehrlichia; Rickettsemia; PCR; DNA sequencing
MeSH headings : Adolescent; Anaplasma / isolation & purification; Anaplasmosis / blood; Anaplasmosis / microbiology; Animals; Dog Diseases / blood; Dog Diseases / microbiology; Dogs; Ehrlichia / isolation & purification; Ehrlichiosis / blood; Ehrlichiosis / microbiology; Ehrlichiosis / veterinary; Female; Humans; Male; Middle Aged; Polymerase Chain Reaction; Serologic Tests
TL;DR: Serology and PCR targeting multiple microbial genes, followed by DNA sequencing, was used to test sequential blood samples and provided molecular evidence supporting intravascular persistence of A. platys and Ehrlichia spp. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Regional Seroreactivity and Vector-Borne Disease Co-Exposures in Dogs in the United States from 2004–2010: Utility of Canine Surveillance

Vector-Borne and Zoonotic Diseases, 14(10), 724–732.

By: C. Yancey*, B. Hegarty n, B. Qurollo n, M. Levy n, A. Birkenheuer n, D. Weber*, P. Diniz*, E. Breitschwerdt n

author keywords: Dirofilaria; Rickettsia; Babesia; Ehrlichia; United States; Anaplasma; Borrelia; Bartonella; Surveillance
MeSH headings : Anaplasma / immunology; Anaplasmosis / epidemiology; Animals; Arachnid Vectors / microbiology; Arachnid Vectors / parasitology; Babesia / immunology; Babesiosis / epidemiology; Bartonella / immunology; Bartonella Infections / epidemiology; Bartonella Infections / veterinary; Borrelia burgdorferi / immunology; Coinfection / veterinary; Dirofilaria immitis / immunology; Dirofilariasis / epidemiology; Dog Diseases / epidemiology; Dog Diseases / microbiology; Dog Diseases / parasitology; Dog Diseases / transmission; Dogs; Ehrlichia / immunology; Ehrlichiosis / epidemiology; Ehrlichiosis / veterinary; Lyme Disease / epidemiology; Retrospective Studies; Rickettsia / immunology; Rickettsia Infections / epidemiology; Rickettsia Infections / veterinary; Seroepidemiologic Studies; Tick-Borne Diseases / epidemiology; Tick-Borne Diseases / microbiology; Tick-Borne Diseases / parasitology; Tick-Borne Diseases / veterinary; Ticks / microbiology; Ticks / parasitology; United States / epidemiology
TL;DR: Notable annual and regional seroreactivity variation was observed with certain pathogens over 7 years of study, suggesting canine surveillance studies may have value in contributing to future VBD knowledge. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2013 journal article

Bartonella henselae infection in a family experiencing neurological and neurocognitive abnormalities after woodlouse hunter spider bites

Parasites & Vectors, 6(1), 98.

By: P. Mascarelli n, R. Maggi n, S. Hopkins*, B. Mozayeni, C. Trull n, J. Bradley n, B. Hegarty n, E. Breitschwerdt n

author keywords: Bartonella; Spiders; Neurological disease; Guillain-Barre Syndrome; Serology; PCR
MeSH headings : Angiomatosis, Bacillary / complications; Angiomatosis, Bacillary / diagnosis; Animals; Bartonella henselae / isolation & purification; Child; Child, Preschool; Cognition Disorders / diagnosis; Cognition Disorders / etiology; Family Health; Female; Humans; Male; Spider Bites / complications; Spiders / microbiology
TL;DR: Although it was not possible to determine whether the family’s B. henselae infections were acquired by spider bites or whether the spiders and woodlice were merely accidental hosts, physicians should consider the possibility that B. Henselae represents an antecedent infection for GBS, CIDP, and non-specific neurocognitive abnormalities. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

Experimental infection of dogs with Bartonella henselae and Bartonella vinsonii subsp. berkhoffii

Veterinary Immunology and Immunopathology, 156(1-2), 153–158.

By: N. Balakrishnan n, N. Cherry n, K. Linder n, E. Pierce n, N. Sontakke n, B. Hegarty n, J. Bradley n, R. Maggi n, E. Breitschwerdt n

author keywords: PCR; Bacteria; Bartonella henselae SA2; Bartonella vinsonii subsp berkhoffii genotype III; Isolation; Dog model
MeSH headings : Animals; Antibodies, Bacterial / blood; Bacteremia / immunology; Bacteremia / microbiology; Bacteremia / veterinary; Bartonella Infections / immunology; Bartonella Infections / microbiology; Bartonella henselae / immunology; DNA, Bacterial / analysis; Dog Diseases / immunology; Dog Diseases / microbiology; Dogs
TL;DR: Following intradermal infection, sequestration of Bartonella spp. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2012 journal article

Ehrlichia muris Infection in a Dog from Minnesota

Journal of Veterinary Internal Medicine, 26(5), 1217–1220.

By: B. Hegarty n, R. Maggi n, P. Koskinen, M. Beall*, M. Eberts*, R. Chandrashekar*, E. Breitschwerdt n

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; Dog Diseases / drug therapy; Dog Diseases / microbiology; Dogs; Ehrlichia / genetics; Ehrlichia / isolation & purification; Ehrlichiosis / drug therapy; Ehrlichiosis / microbiology; Ehrlichiosis / veterinary; Male; Minnesota; Phylogeny; Polymerase Chain Reaction / veterinary; RNA, Ribosomal, 16S / chemistry; RNA, Ribosomal, 16S / genetics
TL;DR: A 6-year-old-male Labrador Retriever from northern Minnesota was examined by a veterinarian in June 2011 because of decreased activity, reluctance to climb stairs, and a history of having 2 attached ticks, but when re-examined in July, the dog had returned to normal activities and normal mobility. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2011 journal article

Ecological Diversity ofBartonellaSpecies Infection Among Dogs and Their Owner in Virginia

Vector-Borne and Zoonotic Diseases, 11(11), 1425–1432.

By: N. Cherry n, R. Maggi n, J. Rossmeisl*, B. Hegarty n & E. Breitschwerdt n

author keywords: Bacteria; Disease; Ecology; Vector
MeSH headings : Animal Husbandry; Animals; Bartonella / genetics; Bartonella / isolation & purification; Bartonella Infections / diagnosis; Bartonella Infections / microbiology; Bartonella Infections / transmission; Breeding; Databases, Nucleic Acid; Dog Diseases / diagnosis; Dog Diseases / microbiology; Dog Diseases / transmission; Dogs; Ecology; Female; Genotype; Humans; Polymerase Chain Reaction; Virginia
TL;DR: Serology, serology, polymerase chain reaction, and enrichment blood culture were used to assess the prevalence of Bartonella sp. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2011 journal article

Hallucinations, Sensory Neuropathy, and Peripheral Visual Deficits in a Young Woman Infected with Bartonella koehlerae

Journal of Clinical Microbiology, 49(9), 3415–3417.

By: E. Breitschwerdt n, P. Mascarelli n, L. Schweickert, R. Maggi n, B. Hegarty n, J. Bradley n, C. Woods*

MeSH headings : Adolescent; Anti-Bacterial Agents / administration & dosage; Antibodies, Bacterial / blood; Bacteremia / diagnosis; Bacteremia / drug therapy; Bacteremia / microbiology; Bacteremia / physiopathology; Bartonella / isolation & purification; Bartonella Infections / diagnosis; Bartonella Infections / drug therapy; Bartonella Infections / microbiology; Bartonella Infections / physiopathology; DNA, Bacterial / blood; Female; Hallucinations / diagnosis; Humans; Treatment Outcome
TL;DR: A young woman experiencing depression, anxiety, mood swings, severe headaches, muscle spasms, interphalangeal joint stiffness, decreased peripheral vision, diminished tactile sensation, and hallucinations was persistently Bartonella koehlerae seroreactive and bacteremic. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2011 journal article

Rickettsia rickettsii transmission by a lone star tick, North Carolina

Emerging Infectious Diseases, 17(5), 873–875.

By: E. Breitschwerdt, B. Hegarty, R. Maggi, P. Lantos, D. Aslett & J. Bradley

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Bartonella vinsonii subsp berkhoffii and Bartonella henselae bacteremia in a father and daughter with neurological disease

Parasites & Vectors, 3.

By: E. Breitschwerdt, R. Maggi, P. Lantos, C. Woods, B. Hegarty & J. Bradley

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

High Prevalence of Tick-Borne Pathogens in Dogs from an Indian Reservation in Northeastern Arizona

Vector-Borne and Zoonotic Diseases, 10(2), 117–123.

By: P. Diniz n, M. Beall*, K. Omark, R. Chandrashekar*, D. Daniluk*, K. Cyr*, J. Koterski*, R. Robbins ...

author keywords: Anaplasma; Babesia; Bartonella; Ehrlichia; Rickettsia; Sentinel
MeSH headings : Anaplasma / isolation & purification; Anaplasmosis / epidemiology; Animals; Arizona / epidemiology; Dog Diseases / epidemiology; Dog Diseases / microbiology; Dog Diseases / parasitology; Dogs; Ehrlichia / isolation & purification; Ehrlichiosis / epidemiology; Ehrlichiosis / veterinary; Female; Host-Pathogen Interactions; Male; Prevalence; Tick Infestations / epidemiology; Tick Infestations / veterinary
TL;DR: Dogs on this Hopi Indian reservation were most frequently infected with E. canis or A. platys; however, more than half of the dogs were exposed to a SFG-Rickettsia species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2010 journal article

PCR amplification of Bartonella koehlerae from human blood and enrichment blood cultures

Parasites & Vectors, 3.

By: E. Breitschwerdt, R. Maggi, B. Mozayeni, B. Hegarty, J. Bradley & P. Mascarelli

Source: NC State University Libraries
Added: August 6, 2018

2009 article

Clinical Relevance of Annual Screening Using a Commercial Enzyme-Linked Immunosorbent Assay (SNAP 3Dx) for Canine Ehrlichiosis

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, Vol. 45, pp. 118–124.

By: B. Hegarty n, P. Diniz n, J. Bradley n, L. Lorentzen n & E. Breitschwerdt n

MeSH headings : Animals; Diagnosis, Differential; Diagnostic Tests, Routine / methods; Diagnostic Tests, Routine / standards; Diagnostic Tests, Routine / veterinary; Dog Diseases / blood; Dog Diseases / diagnosis; Dogs; Ehrlichia / genetics; Ehrlichia / immunology; Ehrlichia / isolation & purification; Ehrlichiosis / blood; Ehrlichiosis / diagnosis; Ehrlichiosis / veterinary; Enzyme-Linked Immunosorbent Assay / standards; Enzyme-Linked Immunosorbent Assay / veterinary; Fluorescent Antibody Technique / standards; Fluorescent Antibody Technique / veterinary; Polymerase Chain Reaction / standards; Polymerase Chain Reaction / veterinary; Thrombocytopenia / blood; United States
TL;DR: In this study, thrombocytopenia was frequently detected in healthy Ehrlichia SNAP 3Dx-positive dogs, whereas active infection was infrequently confirmed by PCR, and treatment based upon screening results alone is not recommended. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Prevalence of Bartonella species antibodies and Bartonella species DNA in the blood of cats with and without fever

Journal of Feline Medicine and Surgery, 11(2), 141–148.

By: M. Lappin*, E. Breitschwerdt n, M. Brewer*, J. Hawley*, B. Hegarty n & S. Radecki*

MeSH headings : Animals; Antibodies, Bacterial / blood; Bartonella / genetics; Bartonella / immunology; Bartonella / isolation & purification; Bartonella Infections / epidemiology; Bartonella Infections / microbiology; Bartonella Infections / veterinary; Bartonella henselae / genetics; Bartonella henselae / immunology; Bartonella henselae / isolation & purification; Blotting, Western / standards; Blotting, Western / veterinary; Cat Diseases / blood; Cat Diseases / epidemiology; Cat Diseases / microbiology; Cats; DNA, Bacterial / blood; Enzyme-Linked Immunosorbent Assay / standards; Enzyme-Linked Immunosorbent Assay / veterinary; Fever / blood; Fever / microbiology; Fever / veterinary; Immunodominant Epitopes / immunology; Immunoglobulin G / blood; Polymerase Chain Reaction / standards; Polymerase Chain Reaction / veterinary; Predictive Value of Tests; Prevalence
TL;DR: The results of this study indicate that in cats, Bartonella species antibody tests cannot predict whether fever is due to Bart onella species infection and should not be used to determine the Bartoneella species infection status. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2008 journal article

Evaluation of conventional and real-time PCR assays for detection and differentiation of Spotted Fever Group Rickettsia in dog blood

Veterinary Microbiology, 129(3-4), 294–303.

By: L. Kidd n, R. Maggi n, P. Diniz n, B. Hegarty n, M. Tucker n & E. Breitschwerdt n

author keywords: dog; PCR; Rickettsia; spotted fever
MeSH headings : Animals; Bacterial Outer Membrane Proteins / genetics; Base Sequence; Boutonneuse Fever / diagnosis; Boutonneuse Fever / microbiology; Boutonneuse Fever / veterinary; DNA Primers; DNA, Bacterial / blood; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; Disease Reservoirs / veterinary; Dog Diseases / blood; Dog Diseases / diagnosis; Dog Diseases / microbiology; Dogs; Gene Amplification; Humans; Molecular Sequence Data; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; Rickettsia / classification; Rickettsia / genetics; Rickettsia / isolation & purification; Rickettsia conorii / classification; Rickettsia conorii / genetics; Rickettsia conorii / isolation & purification; Rickettsia rickettsii / classification; Rickettsia rickettsii / genetics; Rickettsia rickettsii / isolation & purification; Rocky Mountain Spotted Fever / diagnosis; Rocky Mountain Spotted Fever / microbiology; Rocky Mountain Spotted Fever / veterinary; Sensitivity and Specificity; Sentinel Surveillance / veterinary; Species Specificity
TL;DR: Conventional and real-time PCR assays developed using primers that targeted a small region of the ompA gene may assist in the timely diagnosis of infection with SFGRickettsia and facilitate the discovery of novel SFG Rickettsia infecting dogs, and in the investigation of dogs as sentinels for emerging rickettsioses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2008 journal article

Molecular characterization of Bartonella vinsonii subsp berkhoffii genotype III

Journal of Clinical Microbiology, 46(5), 1858–1860.

By: M. Cadenas, J. Bradley, R. Maggi, M. Takara, B. Hegarty & E. Breitschwerdt

Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2008 journal article

Serological and Molecular Prevalence of Borrelia burgdorferi, Anaplasma phagocytophilum, and Ehrlichia Species in Dogs from Minnesota

Vector-Borne and Zoonotic Diseases, 8(4), 455–464.

By: M. Beall*, R. Chandrashekar*, M. Eberts*, K. Cyr*, P. Diniz n, C. Mainville*, B. Hegarty n, J. Crawford n, E. Breitschwerdt n

author keywords: tick(s)
MeSH headings : Anaplasma phagocytophilum / isolation & purification; Animals; Antibodies, Bacterial / blood; Borrelia burgdorferi / isolation & purification; Dog Diseases / blood; Dog Diseases / epidemiology; Dog Diseases / microbiology; Dogs; Ehrlichia / isolation & purification; Ehrlichiosis / epidemiology; Ehrlichiosis / veterinary; Female; Lyme Disease / epidemiology; Lyme Disease / veterinary; Male; Minnesota / epidemiology; Prevalence; Time Factors
TL;DR: A population of 731 naturally exposed pet dogs examined at a private practice in Baxter, Minnesota, an area endemic for Lyme disease and anaplasmosis, was tested by serological and molecular methods for evidence of exposure to or infection with selected vector-borne pathogens, finding A. phagocytophilum DNA was more prevalent in suspected cases of anaplasmsosis or borreliosis than in healthy dogs from the same region. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2007 journal article

BartonellaSpecies in Blood of Immunocompetent Persons with Animal and Arthropod Contact

Emerging Infectious Diseases, 13(6), 938–941.

By: E. Breitschwerdt n, R. Maggi n, A. Duncan n, W. Nicholson*, B. Hegarty n & C. Woods*

MeSH headings : Adult; Animals; Arthropod Vectors; Bacteremia / blood; Bacteremia / microbiology; Bacteriological Techniques; Bartonella / genetics; Bartonella / isolation & purification; Bartonella Infections / epidemiology; Bartonella Infections / genetics; Bartonella Infections / transmission; Bites and Stings; Cats; Dogs; Female; Humans; Immunocompetence; Male; Middle Aged; Molecular Sequence Data; North Carolina / epidemiology; Polymerase Chain Reaction; Seroepidemiologic Studies; Serologic Tests; Zoonoses
TL;DR: Using PCR in conjunction with pre-enrichment culture, it is detected Bartonella henselae and B. vinsonii subspecies berkhoffii in the blood of 14 immunocompetent persons who had frequent animal contact and arthropod exposure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2007 journal article

Canine bartonellosis: serological and molecular prevalence in Brazil and evidence of co-infection with Bartonella henselae and Bartonella vinsonii subsp berkhoffii

VETERINARY RESEARCH, 38(5), 697–710.

By: P. Vissotto De Paiva Diniz n, R. Maggi n, D. Schwartz*, M. Cadenas n, J. Bradley n, B. Hegarty n, E. Breitschwerdt n

author keywords: dogs; Bartonella infections; heart disease; culture; Brazil
MeSH headings : Angiomatosis, Bacillary / epidemiology; Angiomatosis, Bacillary / veterinary; Animals; Antibodies, Bacterial / blood; Bartonella / immunology; Bartonella Infections / epidemiology; Bartonella Infections / veterinary; Bartonella henselae / immunology; Brazil / epidemiology; DNA, Bacterial / analysis; Dog Diseases / epidemiology; Dogs; Female; Gene Amplification; Male; Prospective Studies; Seroepidemiologic Studies
TL;DR: It is concluded that dogs in this study population were infrequently exposed to or infected with a Bartonella species, genetically similar to strains isolated from septicemic cats, dogs, coyotes and human beings from other parts of the world. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Doxycycline Clearance of Experimentally Induced Chronic Ehrlichia Canis Infection in Dogs

Journal of Veterinary Internal Medicine, 21(6), 1237–1242.

By: S. Eddlestone*, P. Diniz n, T. Neer*, S. Gaunt*, R. Corstvet*, D. Cho*, G. Hosgood*, B. Hegarty n, E. Breitschwerdt n

author keywords: canine ehrlichiosis; immunofluorescence assay; platelets; polymerase chain reaction
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Chronic Disease; Dog Diseases / drug therapy; Dogs; Doxycycline / therapeutic use; Ehrlichia canis; Ehrlichiosis / drug therapy; Ehrlichiosis / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2007 journal article

Use of an insect cell culture growth medium to isolate bacteria from horses with effusive, fibrinous pericarditis: A preliminary study

Veterinary Microbiology, 121(1-2), 177–181.

By: S. Jones*, A. Valenzisi, S. Sontakke*, K. Sprayberry, R. Maggi*, B. Hegarty*, E. Breitschwerdt*

author keywords: insect cell culture medium; mare reproductive loss syndrome; 16S rDNA; DNA sequencing
MeSH headings : Animals; Bacteria / genetics; Bacteria / isolation & purification; Bacterial Infections / microbiology; Bacterial Infections / pathology; Bacterial Infections / veterinary; Culture Media; Culture Techniques / veterinary; Disease Outbreaks / veterinary; Horse Diseases / microbiology; Horse Diseases / pathology; Horses; Insecta / cytology; Insecta / microbiology; Kentucky / epidemiology; Pericardial Effusion / microbiology; Pericardial Effusion / pathology; Pericarditis / microbiology; Pericarditis / pathology; Pericarditis / veterinary; Pilot Projects; Retrospective Studies
TL;DR: Bacterial isolation from equine pericardial fluid samples was attempted using an insect cell culture growth medium (ICCGM), but a similar or novel caterpillar-associated bacteria was not identified; however, use of an ICCGM might enhance isolation of bacteria from equines pericARDial fluid. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2006 journal article

A Bartonella vinsonii berkhoffii typing scheme based upon 16S–23S ITS and Pap31 sequences from dog, coyote, gray fox, and human isolates

Molecular and Cellular Probes, 20(2), 128–134.

By: R. Maggi n, B. Chomel*, B. Hegarty n, J. Henn* & E. Breitschwerdt n

author keywords: Bartonella; bacteria; canine; pathogen; classification; genes
MeSH headings : Animals; Bacterial Typing Techniques; Bartonella / classification; Bartonella / genetics; Bartonella / isolation & purification; Bartonella Infections / genetics; Base Sequence; Coyotes / microbiology; DNA, Intergenic / genetics; DNA, Intergenic / isolation & purification; Disease Reservoirs; Dogs / microbiology; Foxes / microbiology; Humans; Molecular Sequence Data; Sequence Homology, Nucleic Acid; Viral Proteins / genetics
TL;DR: Strain typing may help to better define the reservoir potential, carriership patterns, modes of transmission, and geographic distribution for each B. vinsonii berkhoffii type in future molecular epidemiological studies involving Bartonella infection in coyotes, dogs, gray foxes, human beings and potentially other animals or in arthropod vectors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2006 journal article

A serological study of exposure to arthropod-borne pathogens in dogs from northeastern Spain

VETERINARY RESEARCH, 37(2), 231–244.

By: L. Solano-Gallego n, J. Llull*, M. Osso, B. Hegarty n & E. Breitschwerdt n

author keywords: rickettsial pathogens; dogs; Spain
MeSH headings : Animal Husbandry / methods; Animals; Antibodies, Bacterial / blood; Antibodies, Protozoan / blood; Bacterial Infections / blood; Bacterial Infections / epidemiology; Bacterial Infections / veterinary; Dog Diseases / blood; Dog Diseases / epidemiology; Dogs; Female; Male; Protozoan Infections, Animal / blood; Protozoan Infections, Animal / epidemiology; Seasons; Seroepidemiologic Studies; Sex Factors; Spain / epidemiology; Tick-Borne Diseases / blood; Tick-Borne Diseases / epidemiology; Tick-Borne Diseases / veterinary; Ticks / microbiology; Ticks / parasitology
TL;DR: This study indicates that exposure to Rc, Li, Ec or related Ehrlichia spp, Bh and Ap or a related spp. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Comparison of an indirect immunofluorescence assay, western blot analysis, and a commercially available ELISA for detection ofEhrlichia canisantibodies in canine sera

American Journal of Veterinary Research, 67(2), 206–210.

By: T. O'Connor n, J. Hanscom n, B. Hegarty n, R. Groat n & E. Breitschwerdt n

MeSH headings : Animals; Antibodies, Bacterial / blood; Blotting, Western / veterinary; Dog Diseases / blood; Dog Diseases / diagnosis; Dog Diseases / immunology; Dogs; Ehrlichia canis / immunology; Ehrlichia canis / isolation & purification; Ehrlichiosis / blood; Ehrlichiosis / diagnosis; Ehrlichiosis / immunology; Ehrlichiosis / veterinary; Enzyme-Linked Immunosorbent Assay / veterinary; Fluorescent Antibody Technique, Indirect / veterinary
TL;DR: The discrepancy between E canis-IFA, WB analyses, and the commercially available ELISA results for the low-titer serum samples may be related to a high IFA sensitivity or, more likely, a lack of specificity associated with cross-reactivity among Ehrlichia spp. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2006 journal article

Experimental Ehrlichia canis infection in the dog does not cause immunosuppression

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 109(1-2), 117–125.

By: P. Hess n, R. English n, B. Hegarty n, G. Brown n & E. Breitschwerdt n

author keywords: Ehrlichia canis; dog; immunoregulation; immunophenotype analysis; lymphocyte proliferation; LAK; CD8(+) T cell
MeSH headings : Animals; Antibody Formation / immunology; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / microbiology; Dog Diseases / immunology; Dog Diseases / microbiology; Dogs; Doxycycline / therapeutic use; Ehrlichia canis / genetics; Ehrlichia canis / immunology; Ehrlichiosis / blood; Ehrlichiosis / immunology; Ehrlichiosis / microbiology; Ehrlichiosis / veterinary; Female; Flow Cytometry / veterinary; Immunity, Cellular / immunology; Immunodiffusion / veterinary; Immunoglobulins / blood; Immunophenotyping / veterinary; Killer Cells, Lymphokine-Activated / immunology; Random Allocation; Specific Pathogen-Free Organisms
TL;DR: It is suggested that immune responses are not grossly impaired in young dogs during the first several months following experimental E. canis infection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Failure of imidocarb dipropionate to clear experimentally induced Ehrlichia canis infection in dogs

Journal of Veterinary Internal Medicine, 20(4), 840–844.

By: S. Eddlestone, T. Neer, S. Gaunt, R. Corstvet, A. Gill, G. Hosgood, B. Hegarty, E. Breitschwerdt

Source: NC State University Libraries
Added: August 6, 2018

2006 chapter

Molecular characterization of Rickettsia rickettsii infecting dogs and people in North Carolina

In Century of rickettsiology: emerging, reemerging rickettsioses, molecular diagnostics, and emerging veterinary rickettsioses (Vol. 1078, pp. 400–409). Oxford: Blackwell Publishing.

By: L. Kidd, B. Hegarty, D. Sexton & E. Breitschwerdt

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Serological and molecular evidence of exposure to arthropod-borne organisms in cats from northeastern Spain

VETERINARY MICROBIOLOGY, 118(3-4), 274–277.

By: L. Solano-Gallego n, B. Hegarty n, Y. Espada*, J. Llull & E. Breitschwerdt n

author keywords: Spain; cat; vector-borne pathogens; retrovirus
MeSH headings : Anaplasma phagocytophilum / immunology; Animals; Antibodies, Bacterial / blood; Antibodies, Viral / blood; Bartonella henselae / immunology; Cat Diseases / diagnosis; Cat Diseases / epidemiology; Cats; Cross Reactions; Diagnosis, Differential; Ehrlichia canis / immunology; Enzyme-Linked Immunosorbent Assay / methods; Enzyme-Linked Immunosorbent Assay / veterinary; Female; Fluorescent Antibody Technique, Indirect / veterinary; Immunodeficiency Virus, Feline / immunology; Leukemia Virus, Feline / immunology; Male; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; Rickettsia conorii / immunology; Seroepidemiologic Studies; Spain / epidemiology; Tick-Borne Diseases / diagnosis; Tick-Borne Diseases / epidemiology; Tick-Borne Diseases / veterinary; Ticks / microbiology; Ticks / virology
TL;DR: One hundred sixty-eight cat sera from Spain were tested for IgG antibodies to Rickettsia conorii (Rc), Ehrlichia canis (Ec), Anaplasma phagocytophilum (Ap) and Bartonella henselae (Bh) antigens using IFA and for FeLV antigen and FIV antibody by ELISA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

The low seroprevalence of tick-transmitted agents of disease in dogs from southern Ontario and Quebec

Canadian Veterinary Journal, 47(12), 1194–1200.

By: A. Gary, J. Webb, B. Hegarty & E. Breitschwerdt

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Anaplasma phagocytophilum infection (granulocytic anaplasmosis) in a dog from Vancouver Island

Canadian Veterinary Journal, 46(9), 825–827.

By: S. Lester, E. Breitschwerdt, C. Collis & B. Hegarty

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Bartonella Species as a Potential Cause of Epistaxis in Dogs

Journal of Clinical Microbiology, 43(5), 2529–2533.

By: E. Breitschwerdt n, B. Hegarty n, R. Maggi n, E. Hawkins n & P. Dyer*

MeSH headings : Animals; Bartonella Infections / diagnosis; Bartonella Infections / veterinary; Base Sequence; DNA Primers; DNA, Bacterial / genetics; DNA, Bacterial / isolation & purification; Dog Diseases / microbiology; Dogs; Epistaxis / etiology; Epistaxis / microbiology; Epistaxis / veterinary; Female; Male
TL;DR: These cases, in conjunction with previously published reports, support a potential role for Bartonella spp. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2005 journal article

Bartonella quintana in Cynomolgus Monkey (Macaca fascicularis)

Emerging Infectious Diseases, 11(12), 1931–1934.

By: L. O'Rourke*, C. Pitulle n, B. Hegarty n, S. Kraycirik*, K. Killary*, P. Grosenstein*, J. Brown n, E. Breitschwerdt n

MeSH headings : Animals; Bartonella quintana / classification; Bartonella quintana / genetics; Bartonella quintana / isolation & purification; Female; Macaca fascicularis / blood; Macaca fascicularis / microbiology; Phylogeny; Trench Fever / blood; Trench Fever / microbiology; Trench Fever / veterinary
TL;DR: This report describes naturally acquired B. quintana infection in a nonhuman primate. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2004 journal article

Bartonella henselae IgG antibodies are prevalent in dogs from southeastern USA

VETERINARY RESEARCH, 35(5), 585–595.

By: L. Solano-Gallego n, J. Bradley n, B. Hegarty n, B. Sigmon n & E. Breitschwerdt n

author keywords: Bartonella henselae; dog; serology; vector-borne diseases
MeSH headings : Angiomatosis, Bacillary / epidemiology; Angiomatosis, Bacillary / veterinary; Animals; Antibodies, Bacterial / analysis; Bartonella henselae / immunology; Bartonella henselae / isolation & purification; Case-Control Studies; Dog Diseases / epidemiology; Dog Diseases / etiology; Dogs; Female; Immunoglobulin G / immunology; Male; North Carolina / epidemiology; Seroepidemiologic Studies
TL;DR: This study indicates that B. henselae IgG antibodies are prevalent in healthy and sick dogs living in the south-eastern USA, and further studies are needed to evaluate the epidemiological, clinical and zoonotic relevance of B.Henselae infection in dogs. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Chronic canine ehrlichiosis (Ehrlichia canis): A retrospective study of 19 natural cases

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 40(3), 174–184.

By: M. Mylonakis n, A. Koutinas n, E. Breitschwerdt n, B. Hegarty n, C. Billinis n, L. Leontides n, V. Kontos n

MeSH headings : Animals; Antibodies, Bacterial / blood; Antigens, Bacterial / immunology; Blood Cell Count / veterinary; Chronic Disease / therapy; Dog Diseases / blood; Dog Diseases / mortality; Dog Diseases / pathology; Dogs; Ehrlichia canis / immunology; Ehrlichia canis / isolation & purification; Ehrlichiosis / blood; Ehrlichiosis / mortality; Ehrlichiosis / pathology; Ehrlichiosis / veterinary; Female; Fluorescent Antibody Technique, Indirect / methods; Fluorescent Antibody Technique, Indirect / veterinary; Male; Retrospective Studies; Seasons
TL;DR: Nineteen dogs from Greece with chronic ehrlichiosis were studied, and concurrent infections did not appear to substantially influence the clinical course and final outcome of the chronic canine ehrliciosis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Comparison of results for serologic testing and a polymerase chain reaction assay to determine the prevalence of stray dogs in eastern Tennessee seropositive to Ehrlichia canis

American Journal of Veterinary Research, 65(9), 1200–1203.

By: R. Seaman n, S. Kania n, B. Hegarty n, A. Legendre n & E. Breitschwerdt n

MeSH headings : Animals; Dog Diseases / epidemiology; Dog Diseases / microbiology; Dogs; Ehrlichia canis; Ehrlichiosis / epidemiology; Ehrlichiosis / veterinary; Enzyme-Linked Immunosorbent Assay / methods; Enzyme-Linked Immunosorbent Assay / veterinary; Fluorescent Antibody Technique, Indirect / methods; Fluorescent Antibody Technique, Indirect / veterinary; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; Seroepidemiologic Studies; Serologic Tests / veterinary; Tennessee / epidemiology
TL;DR: The discordant ELISA, IFA, and PCR results obtained in this study were unexpected and may have been related to exposure of dogs to an Ehrlichia species other than E. canis, such as E. ewingii. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2004 journal article

ORCHITIS IN TWO DOGS WITH ROCKY MOUNTAIN SPOTTED FEVER

Veterinary Radiology & Ultrasound, 45(5), 458–465.

By: C. Ober n, K. Spaulding n, E. Breitschwerdt n, D. Malarkey* & B. Hegarty n

author keywords: orchitis; rickettsia; testicle; ultrasound
MeSH headings : Animals; Diagnosis, Differential; Dog Diseases / diagnostic imaging; Dogs; Male; Orchitis / complications; Orchitis / diagnostic imaging; Orchitis / veterinary; Rocky Mountain Spotted Fever / complications; Rocky Mountain Spotted Fever / veterinary; Ultrasonography
TL;DR: Two dogs with testicular swelling were sonographically diagnosed with orchitis and were subsequently diagnosed with Rocky Mountain spotted fever (RMSF) and should be considered in any dog with vascular insult to the testes, especially when other signs of systemic illness are involved. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2003 journal article

Molecular identification of Ehrlichia ewingii infection in dogs: 15 cases (1997-2001)

JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 222(8), 1102–1107.

By: R. Goodman n, E. Hawkins*, N. Olby*, C. Grindem*, B. Hegarty* & E. Breitschwerdt*

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; DNA, Bacterial / blood; DNA, Bacterial / chemistry; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dog Diseases / microbiology; Dogs; Doxycycline / therapeutic use; Ehrlichia / genetics; Ehrlichia / isolation & purification; Ehrlichiosis / diagnosis; Ehrlichiosis / drug therapy; Ehrlichiosis / microbiology; Ehrlichiosis / veterinary; Female; Fever / microbiology; Fever / veterinary; Lameness, Animal / microbiology; Male; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; Retrospective Studies; Thrombocytopenia / microbiology; Thrombocytopenia / veterinary; Treatment Outcome
TL;DR: PCR testing for E ewingii infection should be considered in dogs with fever, neutrophilic polyarthritis, unexplained ataxia or paresis, thrombocytopenia, or unexplained reactive lymphocytes, and indogs with clinical signs suggestive of ehrlichiosis that are seronegative for E canis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

The Immunologic Response of Dogs to Bartonella Vinsonii Subspecies Berkhoffii Antigens: as Assessed by Western Immunoblot Analysis

Journal of Veterinary Diagnostic Investigation, 15(4), 349–354.

By: E. Breitschwerdt n, J. Suksawat*, B. Chomel* & B. Hegarty n

MeSH headings : Animals; Antigens, Viral / analysis; Bartonella / immunology; Bartonella / pathogenicity; Bartonella Infections / immunology; Bartonella Infections / veterinary; Blotting, Western / veterinary; Diagnosis, Differential; Dog Diseases / immunology; Dog Diseases / microbiology; Dogs; Sensitivity and Specificity
TL;DR: The results of this study indicate that WI using agar-grown or cell culture–grown B. vinsonii (berkhoffii) antigens produce identical patterns of antigenic protein recognition. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2002 journal article

Feline ehrlichiosis. The genetic identification of the agent in Avo cats

Pratique Medicale Et Chirurgicale De L'Animal De Compagnie, 37(3), 235–238.

By: J. Beaufils, E. Breitschwerdt, S. Hancock, B. Hegarty, J. Martin-Granel, P. Jumelle, M. Barbault-Jumelle, A. Blavier

Source: NC State University Libraries
Added: August 6, 2018

2002 article

Molecular evidence supporting Ehrlichia canis-like infection in cats

JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 16, pp. 642–649.

By: E. Breitschwerdt n, A. Abrams-Ogg n, M. Lappin n, D. Bienzle n, S. Hancock n, S. Cowan n, J. Clooten n, B. Hegarty n, E. Hawkins n

author keywords: antinuclear antibodies; leukemia; polyarthritis; thrombocytopenia
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Naturally OccurringEhrlichia chaffeensisInfection in Two Prosimian Primate Species: Ring-tailed Lemurs (Lemur catta) and Ruffed Lemurs (Varecia variegata)

Emerging Infectious Diseases, 8(12), 1497–1500.

By: C. Williams*, J. Van Steenhouse, J. Bradley n, S. Hancock n, B. Hegarty n & E. Breitschwerdt n

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Disease Outbreaks / veterinary; Doxycycline / therapeutic use; Ehrlichia chaffeensis / isolation & purification; Ehrlichiosis / blood; Ehrlichiosis / drug therapy; Ehrlichiosis / veterinary; Lemur; North Carolina; Polymerase Chain Reaction
TL;DR: A naturally occurring infection of Ehrlichia chaffeensis in lemurs is described and Organisms were cultured from the blood of one lemur exhibiting clinical and hematologic abnormalities similar to those of humans infected with E. Chaffeensis. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2002 journal article

Visceral leishmaniasis in a New York foxhound kennel

JOURNAL OF VETERINARY INTERNAL MEDICINE, 16(1), 34–44.

By: A. Gaskin n, P. Schantz*, J. Jackson*, A. Birkenheuer n, L. Tomlinson n, M. Gramiccia*, M. Levy n, F. Steurer* ...

author keywords: canine; dogs; Leishmania; sand fly
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 journal article

Assessing the association between the geographic distribution of deer ticks and seropositivity rates to various tick-transmitted disease organisms in dogs

Journal of the American Veterinary Medical Association, 218(7), 1092–1097.

By: V. Hinrichsen, U. Whitworth, E. Breitschwerdt*, B. Hegarty* & T. Mather

MeSH headings : Animals; Antibodies, Bacterial / blood; Antibodies, Bacterial / immunology; Arachnid Vectors / microbiology; Arachnid Vectors / physiology; Bartonella / immunology; Bartonella Infections / epidemiology; Bartonella Infections / transmission; Bartonella Infections / veterinary; Borrelia burgdorferi Group / immunology; Deer; Dog Diseases / epidemiology; Dog Diseases / microbiology; Dog Diseases / transmission; Dogs; Ehrlichia / immunology; Ehrlichiosis / epidemiology; Ehrlichiosis / transmission; Ehrlichiosis / veterinary; Fluorescent Antibody Technique, Indirect / methods; Fluorescent Antibody Technique, Indirect / veterinary; Ixodes / microbiology; Ixodes / physiology; Lyme Disease / epidemiology; Lyme Disease / transmission; Lyme Disease / veterinary; Rhode Island / epidemiology; Rickettsia rickettsii / immunology; Rocky Mountain Spotted Fever / epidemiology; Rocky Mountain Spotted Fever / transmission; Rocky Mountain Spotted Fever / veterinary; Seroepidemiologic Studies; Tick-Borne Diseases / epidemiology; Tick-Borne Diseases / transmission; Tick-Borne Diseases / veterinary
TL;DR: Information concerning tick distributions may be useful in predicting the pattern of disease associated with particular tick species and may aid diagnostic, prevention, and control efforts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2001 journal article

Infection of Fetal Feline Brain Cells in Culture with Bartonella henselae

Infection and Immunity, 69(1), 564–569.

By: K. Munana n, S. Vitek n, B. Hegarty n, D. Kordick n & E. Breitschwerdt n

Contributors: K. Muñana n, S. Vitek n, B. Hegarty n, D. Kordick n & E. Breitschwerdt n

MeSH headings : Animals; Astrocytes / microbiology; Bartonella henselae / physiology; Brain / cytology; Brain / microbiology; Brain Diseases / etiology; Cats; Cells, Cultured; DNA, Bacterial / analysis; Female; Fetus / microbiology; Microglia / microbiology; Microscopy, Electron; Pregnancy
TL;DR: A role for microglia in the pathogenesis of B. henselae-associated neurological disease is suggested, and evidence of infection was seen in Bartonella-inoculated astrocyte cultures. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2001 journal article

Serologic and molecular evidence of coinfection with multiple vector-borne pathogens in dogs from Thailand

JOURNAL OF VETERINARY INTERNAL MEDICINE, 15(5), 453–462.

By: J. Suksawat*, X. Yu*, S. Hancock n, B. Hegarty n, P. Nilkumhang* & E. Breitschwerdt n

author keywords: canine; diseases; polymerase chain reaction; serology; ticks
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Seroprevalence of Ehrlichia canis, Ehrlichia equi, and Ehrlichia risticii in sick dogs from North Carolina and Virginia

Journal of Veterinary Internal Medicine, 14(1), 50–55.

By: J. Suksawat n, B. Hegarty n & E. Breitschwerdt n

TL;DR: Ehrlichia canis, E. equi, and E. risticii seroprevalence was determined by microimmunofluorescent antibody testing in a sequential population of 1,845 sick dogs admitted during a 1-year period to the North Carolina State University Veterinary Teaching Hospital to indicate that ehrlichiosis was not diagnosed in the majority of serologically confirmed cases. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

1999 journal article

Coinfection with multiple tick-borne pathogens in a Walker Hound kennel in North Carolina

Journal of Clinical Microbiology, 37(8), 2631–2638.

By: S. Kordick, E. Breitschwerdt, B. Hegarty, K. Southwick, C. Colitz, S. Hancock, J. Bradley, R. Rumbough, J. McPherson, J. MacCormack

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Efficacy of Doxycycline, Azithromycin, or Trovafloxacin for Treatment of Experimental Rocky Mountain Spotted Fever in Dogs

Antimicrobial Agents and Chemotherapy, 43(4), 813–821.

By: E. Breitschwerdt*, M. Papich n, B. Hegarty*, B. Gilger*, S. Hancock & M. Davidson*

MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / therapeutic use; Anti-Infective Agents / blood; Anti-Infective Agents / therapeutic use; Azithromycin / blood; Azithromycin / therapeutic use; Capillary Permeability / drug effects; DNA, Bacterial / analysis; Dogs; Doxycycline / blood; Doxycycline / therapeutic use; Female; Fluoroquinolones; Guinea Pigs; Male; Naphthyridines / blood; Naphthyridines / therapeutic use; Polymerase Chain Reaction; Rickettsia rickettsii / drug effects; Rickettsia rickettsii / isolation & purification; Rocky Mountain Spotted Fever / drug therapy; Rocky Mountain Spotted Fever / immunology; Treatment Outcome
TL;DR: Doxycycline and trovafloxacin was as efficacious as doxycycline but azithromycin proved less efficacious, possibly due to the short duration of administration. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

1999 journal article

Platelet-associated immunoglobulin (antiplatelet antibody) in canine Rocky Mountain spotted fever and ehrlichiosis

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 35(1), 56–61.

By: C. Grindem n, E. Breitschwerdt*, P. Perkins*, L. Cullins, T. Thomas & B. Hegarty*

MeSH headings : Animals; Antibodies, Bacterial / blood; Autoantibodies / blood; Blood Platelets / immunology; Dog Diseases / blood; Dog Diseases / immunology; Dogs; Ehrlichia / immunology; Ehrlichiosis / blood; Ehrlichiosis / immunology; Ehrlichiosis / veterinary; Flow Cytometry / veterinary; Fluorescent Antibody Technique, Indirect / veterinary; Immunoglobulin G / blood; Rickettsia rickettsii / immunology; Rocky Mountain Spotted Fever / blood; Rocky Mountain Spotted Fever / immunology; Rocky Mountain Spotted Fever / veterinary; Thrombocytopenia / blood; Thrombocytopenia / immunology; Thrombocytopenia / veterinary
TL;DR: Results of this study indicate an immunological component for rickettsial thrombocytopenia, and current therapeutic recommendations, especially regarding avoiding the use of immunosuppressive drugs in patients with ricksettsial diseases, need to be critically reviewed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 article

The incidence of ehrlichial and rickettsial infection in patients with unexplained fever and recent history of tick bite in central North Carolina

Carpenter, C. F., Gandhi, T. K., Kong, L. K., Corey, G. R., Chen, S. M., Walker, D. H., … al. (1999, September). JOURNAL OF INFECTIOUS DISEASES, Vol. 180, pp. 900–903.

By: C. Carpenter, T. Gandhi, L. Kong, G. Corey*, S. Chen, D. Walker*, J. Dumler*, E. Breitschwerdt n ...

MeSH headings : Adult; Animals; Antibodies, Bacterial / blood; Comorbidity; Ehrlichia chaffeensis / isolation & purification; Ehrlichiosis / blood; Ehrlichiosis / epidemiology; Fever of Unknown Origin / blood; Fever of Unknown Origin / etiology; Fever of Unknown Origin / microbiology; Humans; Incidence; Insect Bites and Stings; Leukocyte Count; North Carolina / epidemiology; Platelet Count; Polymerase Chain Reaction; Rickettsia / isolation & purification; Rickettsia Infections / blood; Rickettsia Infections / epidemiology; Ticks
TL;DR: It is concluded that ehrlichial infections may be as common as spotted fever group rickettsial infections in febrile patients from central North Carolina with a recent history of tick bite. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1998 journal article

A survey of tick-borne bacteria and protozoa in naturally exposed dogs from Israel

VETERINARY PARASITOLOGY, 74(2-4), 133–142.

author keywords: dog; Ehrlichia canis; Bartonella vinsonii; Babesia canis; Babesia gibsoni; Rickettsia conorii; Israel
MeSH headings : Animals; Animals, Domestic / microbiology; Animals, Domestic / parasitology; Antibodies, Bacterial / blood; Antibodies, Bacterial / immunology; Antibodies, Protozoan / blood; Antibodies, Protozoan / immunology; Babesia / immunology; Bacterial Infections / blood; Bacterial Infections / epidemiology; Bacterial Infections / veterinary; Bartonella / immunology; Blotting, Western / veterinary; Borrelia burgdorferi Group / immunology; Case-Control Studies; Data Collection; Dog Diseases / blood; Dog Diseases / epidemiology; Dogs; Ehrlichia / immunology; Enzyme-Linked Immunosorbent Assay / veterinary; Female; Fluorescent Antibody Technique, Indirect / veterinary; Israel / epidemiology; Male; Prevalence; Protozoan Infections, Animal / blood; Protozoan Infections, Animal / epidemiology; Rickettsia / immunology; Tick-Borne Diseases / blood; Tick-Borne Diseases / epidemiology; Tick-Borne Diseases / veterinary; Ticks
TL;DR: Western blot analysis for antibodies reactive to B. burgdorferi identified genus-specific antiflagellin antibodies indicating that dogs in Israel are exposed to a Borrelia species, indicating that Lyme borreliosis in people in Israel is likely. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1998 journal article

Doxycycline hyclate treatment of experimental canine ehrlichiosis followed by challenge inoculation with two Ehrlichia canis strains

Antimicrobial Agents and Chemotherapy, 42(2), 362–368.

By: E. Breitschwerdt, B. Hegarty & S. Hancock

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Dual Infection with Ehrlichia chaffeensis and a Spotted Fever Group Rickettsia: A Case Report

Emerging Infectious Diseases, 4(2), 311–316.

By: D. Sexton*, G. Corey*, C. Carpenter*, L. Kong*, T. Gandhi*, E. Breitschwerdt n, B. Hegarty n, S. Chen* ...

MeSH headings : Adult; Ehrlichia chaffeensis / genetics; Ehrlichia chaffeensis / isolation & purification; Ehrlichiosis / complications; Ehrlichiosis / diagnosis; Fluorescent Antibody Technique; Genes, Bacterial; Humans; Male; Polymerase Chain Reaction; Rickettsia rickettsii / isolation & purification; Rocky Mountain Spotted Fever / blood; Rocky Mountain Spotted Fever / complications; Rocky Mountain Spotted Fever / diagnosis; Sequence Analysis, DNA; Skin / microbiology
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

1998 journal article

Granulocytic Ehrlichiosis in Dogs from North Carolina and Virginia

Journal of Veterinary Internal Medicine, 12(2), 61–70.

By: E. Goldman*, E. Breitschwerdt n, C. Grindem n, B. Hegarty*, J. Walls* & J. Dumler*

author keywords: anemia; polyarthritis; polymerase chain reaction; tick-transmitted rickettsia
MeSH headings : Animals; Dog Diseases; Dogs; Ehrlichia / classification; Ehrlichia / genetics; Ehrlichia / isolation & purification; Ehrlichiosis / blood; Ehrlichiosis / veterinary; Genes, Bacterial; Humans; Medical Records; Neutrophils / parasitology; North Carolina; Polymerase Chain Reaction; RNA, Ribosomal, 16S / genetics; Retrospective Studies; Virginia
TL;DR: Serologic or molecular results support the possibility of E. ewingii, E. equi, and E. canis coinfection or serologic cross-reactivity among canine granulocytic and monocytic Ehrlichia species in dogs from North Carolina and Virginia. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

1998 journal article

Sequential evaluation of dogs naturally infected with Ehrlichia canis, Ehrlichia chaffeensis, Ehrlichia equi, Ehrlichia ewingii, or Bartonella vinsonii

Journal of Clinical Microbiology, 36(9), 2645–2651.

By: E. Breitschwerdt, B. Hegarty & S. Hancock

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Immunoblot Analysis of the Immunoglobulin G Response to Ehrlichia Canis in Dogs: An International Survey

Journal of Veterinary Diagnostic Investigation, 9(1), 32–38.

By: B. Hegarty n, M. Levy n, R. Gager n & E. Breitschwerdt n

MeSH headings : Animals; Antibodies, Bacterial / blood; Antibody Formation; Antigens, Bacterial / immunology; Blotting, Western / methods; Dog Diseases; Dogs; Ehrlichia / genetics; Ehrlichia / immunology; Ehrlichiosis / immunology; Ehrlichiosis / veterinary; France; Genetic Variation; Immunoglobulin G / blood; Israel; Italy; United States; United States Virgin Islands; Zimbabwe
TL;DR: The results indicate that although relatively homogeneous, antigenic diversity may exist among E. canis organisms in different regions of the world, and that unique major proteins were observed in dog sera from Italy and Zimbabwe. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

1997 journal article

Prednisolone at anti-inflammatory or immunosuppressive dosages in conjunction with doxycycline does not potentiate the severity of Rickettsia rickettsii infection in dogs.

Antimicrobial Agents and Chemotherapy, 41(1), 141–147.

By: E. Breitschwerdt n, M. Davidson n, B. Hegarty n, M. Papich n & C. Grindem n

MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / therapeutic use; Anti-Inflammatory Agents / blood; Anti-Inflammatory Agents / therapeutic use; Antibodies, Bacterial / analysis; Dogs; Doxycycline / blood; Doxycycline / therapeutic use; Drug Therapy, Combination; Female; Immunosuppressive Agents / blood; Immunosuppressive Agents / therapeutic use; Prednisolone / blood; Prednisolone / therapeutic use; Rickettsia rickettsii / immunology; Rickettsia rickettsii / isolation & purification; Rocky Mountain Spotted Fever / blood; Rocky Mountain Spotted Fever / drug therapy
TL;DR: It is concluded that the concurrent use of anti-inflammatory or immunosuppressive doses of prednisolone in conjunction with doxycycline, early in the course of experimental R MSF, confers no clinically relevant detrimental effects and that additional studies might be indicated to detect possible beneficial effects in cases of severe or potentially fulminant RMSF. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

1996 journal article

Myocarditis in mice and guinea pigs experimentally infected with a canine-origin Borrelia isolate from Florida

American Journal of Veterinary Research, 57(4), 505–511.

By: E. Breitschwerdt, F. Geoly, D. Meuten, J. Levine, P. Howard, B. Hegarty, L. Stafford

Source: NC State University Libraries
Added: August 6, 2018

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