Bram Frohock

Works (4)

Updated: March 9th, 2024 05:01

2024 journal article

Expanded library of novel 2,3-pyrrolidinedione analogues exhibit anti-biofilm activity

Bioorganic & Medicinal Chemistry Letters, 99, 129609.

By: M. Nie n, M. Alejandro Valdes-Pena n, B. Frohock n, E. Smits n, J. Daiker n, J. Gilbertie n, L. Schnabel n , J. Pierce n 

author keywords: Natural products; Antibiotics; Antimicrobial resistance; Biofilms; 2 3-pyrrolidinedione
MeSH headings : Anti-Bacterial Agents / pharmacology; Staphylococcus aureus; Methicillin-Resistant Staphylococcus aureus; Methicillin Resistance; Biofilms; Microbial Sensitivity Tests
topics (OpenAlex): Antimicrobial Peptides and Activities; Chemical Synthesis and Analysis; Phenothiazines and Benzothiazines Synthesis and Activities
TL;DR: A new library of 2,3-pyrrolidinedione analogues is reported that expands on the previous report on the antimicrobial studies of this heterocyclic scaffold and displayed antibiofilm properties and represent intriguing scaffolds for further optimization and development. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: January 7, 2024

2022 article

Engagement of Students in an Organic Chemistry Lecture/Lab Course via Social Media Using Twitter

Frohock, B. H., Macallister, C. A., & Gallardo-Williams, M. T. (2022, August 15). Journal of Chemical Education, Vol. 8.

By: B. Frohock n, C. Macallister n & M. Gallardo-Williams n 

author keywords: Second-Year Undergraduate; Organic Chemistry; Internet; Web-Based Learning; Multimedia-Based Learning; Computer-Based Learning
topics (OpenAlex): Impact of Technology on Adolescents; Online and Blended Learning; Mobile Learning in Education
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4. Quality Education (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 29, 2022

2019 article

5‐Benzylidene‐4‐Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms

Frohock, B. H., Gilbertie, J. M., Daiker, J. C., Schnabel, L. V., & Pierce, J. G. (2019, November 5). ChemBioChem, Vol. 12, pp. 933–937.

By: B. Frohock n, J. Gilbertie n, J. Daiker n, L. Schnabel n  & J. Pierce n 

MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / pharmacology; Benzylidene Compounds / pharmacology; Biofilms / drug effects; Drug Synergism; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Oxazolidinones / pharmacology; Staphylococcus aureus / physiology; Structure-Activity Relationship
topics (OpenAlex): Synthesis and Catalytic Reactions; Click Chemistry and Applications; Chemical Synthesis and Analysis
TL;DR: An expanded set of 5‐benzylidene‐4‐oxazolidinones is reported that is able to inhibit the formation of Staphylococcus aureus biofilms, disperse preformed biofilm, and are able to significantly reduce the bacterial load in a robust collagen‐matrix model of biofilm infection. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 13, 2020

2017 article

#IHeartChemistryNCSU: free choice, content, and elements of science communication as the framework for an introductory organic chemistry project

Frohock, B. H., Winterrowd, S. T., & Gallardo-Williams, M. T. (2017, November 2). Chemistry Education Research and Practice, Vol. 19, pp. 240–250.

By: B. Frohock n, S. Winterrowd n & M. Gallardo-Williams n 

topics (OpenAlex): Various Chemistry Research Topics; Innovative Teaching and Learning Methods; Educational Strategies and Epistemologies
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4. Quality Education (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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