@article{nie_valdes-pena_frohock_smits_daiker_gilbertie_v. schnabel_pierce_2024, title={Expanded library of novel 2,3-pyrrolidinedione analogues exhibit anti-biofilm activity}, volume={99}, ISSN={["1464-3405"]}, url={https://doi.org/10.1016/j.bmcl.2024.129609}, DOI={10.1016/j.bmcl.2024.129609}, abstractNote={Herein we report a new library of 2,3-pyrrolidinedione analogues that expands on our previous report on the antimicrobial studies of this heterocyclic scaffold. The novel 2,3-pyrrolidinediones reported herein have been evaluated against S. aureus and methicillin-resistant S. aureus (MRSA) biofilms, and this work constitutes our first report on the antibiofilm properties of this class of compounds. The antibiofilm activity of these 2,3-pyrrolidinediones has been assessed through minimum biofilm eradication concentration (MBEC) and minimum biofilm inhibition concentration (MBIC) assays. The compounds displayed antibiofilm properties and represent intriguing scaffolds for further optimization and development.}, journal={BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, author={Nie, Minhua and Valdes-Pena, M. Alejandro and Frohock, Bram H. and Smits, Emma and Daiker, Jennifer C. and Gilbertie, Jessica M. and V. Schnabel, Lauren and Pierce, Joshua G.}, year={2024}, month={Feb} } @article{frohock_macallister_gallardo-williams_2022, title={Engagement of Students in an Organic Chemistry Lecture/Lab Course via Social Media Using Twitter}, volume={8}, ISSN={["1938-1328"]}, DOI={10.1021/acs.jchemed.2c00237}, abstractNote={A teaching team composed of a faculty member (lecture) and a graduate teaching assistant (lab) endeavored to engage students enrolled in several sections of the same organic chemistry course through the use of social media. Students were encouraged to follow both instructors on Twitter and were asked to share aspects of the class using the social media site. Instructors regularly posted content and links relevant to the course and interacted with students, modeling professional social media interactions. Although the extent of student participation was limited, it was determined that this is a possible complementary outlet for class communication, sharing of information, and limited data gathering. In the lab courses, students were found to be more reticent to engage but did use the “follow” function to add the lab instructor to their Twitter networks. Lab and lecture courses were surveyed in order to determine factors affecting student engagement on social media. Results of the surveys and data collected in both courses are discussed with an emphasis on best practices.}, journal={JOURNAL OF CHEMICAL EDUCATION}, author={Frohock, Bram H. and Macallister, Cade A. and Gallardo-Williams, Maria T.}, year={2022}, month={Aug} } @article{frohock_gilbertie_daiker_schnabel_pierce_2019, title={5-Benzylidene-4-Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms}, volume={12}, ISBN={1439-7633}, url={https://doi.org/10.1002/cbic.201900633}, DOI={10.1002/cbic.201900633}, abstractNote={Abstract}, journal={CHEMBIOCHEM}, publisher={Wiley}, author={Frohock, Bram H. and Gilbertie, Jessica M. and Daiker, Jennifer C. and Schnabel, Lauren V and Pierce, Joshua G.}, year={2019} } @article{frohock_winterrowd_gallardo-williams_2018, title={#IHeartChemistryNCSU: free choice, content, and elements of science communication as the framework for an introductory organic chemistry project}, volume={19}, ISSN={["1109-4028"]}, DOI={10.1039/c7rp00132k}, abstractNote={Students in a large introductory organic chemistry class were given the freedom to choose an organic compound of interest and were challenged to develop an educational object (physical or digital) designed to be shared with the broader publicviasocial media. Analysis of the project results shows that most students appreciated the open nature of the assignment, and engaged in self-regulated learning by reflecting and improving on their educational object design along each step of the project. Subjects varied widely depending on the students’ personal interests, and many different educational objects were produced and shared using diverse social media outlets. As a result of this project, students reported positive outcomes including increased interest in organic chemistry and science in general as well as the acquisition of practical skills such as science communication and visual representation of science. These skills were perceived by students as being beneficial for future professional endeavors. This report describes the design and outcomes of the project, including the choice of subjects, representations, and social media channels.}, number={1}, journal={CHEMISTRY EDUCATION RESEARCH AND PRACTICE}, publisher={Royal Society of Chemistry (RSC)}, author={Frohock, Bram H. and Winterrowd, Samantha T. and Gallardo-Williams, Maria T.}, year={2018}, month={Jan}, pages={240–250} }