Brent Hardin Wyatt

Works (8)

Updated: October 26th, 2024 05:03

2024 article

Comparative toxicogenomics database's 20th anniversary: update 2025

Davis, A. P., Wiegers, T. C., Sciaky, D., Barkalow, F., Strong, M., Wyatt, B., … Mattingly, C. J. (2024, October 10). NUCLEIC ACIDS RESEARCH, Vol. 10.

By: A. Davis n, T. Wiegers n, D. Sciaky n, F. Barkalow n, M. Strong n, B. Wyatt n, J. Wiegers n, R. McMorran n, S. Abrar n, C. Mattingly n 

Sources: Web Of Science, NC State University Libraries
Added: October 21, 2024

2024 journal article

Developmental regulation of cellular metabolism is required for intestinal elongation and rotation

DEVELOPMENT, 151(1).

By: J. Grzymkowski n, Y. Chiu, D. Jima n, B. Wyatt n, S. Jayachandran n, W. Stutts n , N. Nascone-Yoder n 

author keywords: Intestine; Metabolism; Rotation; Electron transport chain; Elongation; Atrazine; Xenopus
TL;DR: Roles for metabolism in gut morphogenesis are revealed and implicate defective gut tube elongation and/or metabolic perturbations in the etiology of intestinal malrotation. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 22, 2024

2024 journal article

Transforming environmental health datasets from the comparative toxicogenomics database into chord diagrams to visualize molecular mechanisms

FRONTIERS IN TOXICOLOGY, 6.

By: B. Wyatt n, A. Davis n, T. Wiegers n, J. Wiegers n, S. Abrar n, D. Sciaky n, F. Barkalow n, M. Strong n, C. Mattingly n 

author keywords: data visualization; chord diagram; r; molecular mechanisms; environmental health; database; tetramers
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Sources: Web Of Science, NC State University Libraries
Added: August 19, 2024

2023 journal article

CTD tetramers: a new online tool that computationally links curated chemicals, genes, phenotypes, and diseases to inform molecular mechanisms for environmental health

TOXICOLOGICAL SCIENCES, 195(2), 155–168.

By: A. Davis n, T. Wiegers n, J. Wiegers n, B. Wyatt n, R. Johnson n, D. Sciaky n, F. Barkalow n, M. Strong n, A. Planchart n , C. Mattingly n 

author keywords: database tool; chemical-disease pathway; molecular mechanisms; environmental health; knowledge gaps; adverse outcome pathway
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Sources: Web Of Science, NC State University Libraries
Added: April 1, 2024

2023 journal article

Rare variants in <i>CAPN2</i> increase risk for isolated hypoplastic left heart syndrome

HUMAN GENETICS AND GENOMICS ADVANCES, 4(4).

By: E. Blue *, J. White *, M. Dush n, W. Gordon *, B. Wyatt n, P. White *, C. Marvin*, E. Helle * ...

TL;DR: The findings show that iHLHS is typically not a Mendelian condition, demonstrate that CAPN2 variants increase risk of i HLHS, and identify a novel pathway involved in HLHS pathogenesis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: October 16, 2023

2021 journal article

E-liquids and vanillin flavoring disrupts retinoic acid signaling and causes craniofacial defects in Xenopus embryos

DEVELOPMENTAL BIOLOGY, 481, 14–29.

By: A. Dickinson *, S. Turner *, S. Wahl *, A. Kennedy *, B. Wyatt n & D. Howton*

author keywords: e-liquid; Vaping; Teratogen; Vanillin; Xenopus; Craniofacial
MeSH headings : Animals; Benzaldehydes / administration & dosage; Benzaldehydes / pharmacology; Craniofacial Abnormalities / chemically induced; Craniofacial Abnormalities / embryology; Embryo, Nonmammalian / embryology; Embryo, Nonmammalian / pathology; Flavoring Agents / adverse effects; Flavoring Agents / pharmacology; Signal Transduction / drug effects; Tobacco Products / toxicity; Tretinoin / metabolism; Xenopus laevis
TL;DR: It is determined that e-liquid chemicals, in particular vanillin, can cause craniofacial defects potentially by dysregulating retinoic acid signaling, and the evaluation of vanillin and other such flavoring additives in e-liquids on mammalian development is warranted. (via Semantic Scholar)
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Source: Web Of Science
Added: October 12, 2021

2021 journal article

Single-minded 2 is required for left-right asymmetric stomach morphogenesis

DEVELOPMENT, 148(17).

By: B. Wyatt n, N. Amin n, K. Bagley n, D. Wcisel n, M. Dush n, J. Yoder n , N. Nascone-Yoder n 

author keywords: right asymmetry; Stomach; Morphogenesis; Pitx2; Sim2; Down syndrome; Frog
MeSH headings : Animals; Anura; Basic Helix-Loop-Helix Transcription Factors / genetics; Basic Helix-Loop-Helix Transcription Factors / metabolism; Body Patterning; Embryo, Nonmammalian; Endoderm / embryology; Endoderm / metabolism; Gene Expression Regulation, Developmental; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Morphogenesis; Stomach / embryology; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR: It is demonstrated that sim2 functions downstream of LR patterning cues to regulate key cellular properties and behaviors in the left stomach epithelium that drive asymmetric curvature, and has implications for dose-dependent roles of laterality factors in non-laterality-related birth defects. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: September 27, 2021

2020 review

The twists and turns of left-right asymmetric gut morphogenesis

[Review of ]. DEVELOPMENT, 147(19).

By: J. Grzymkowski n, B. Wyatt n & N. Nascone-Yoder n 

author keywords: Gut tube; Intestine; Laterality; Left-right asymmetry; Morphogenesis; Stomach
MeSH headings : Animals; Body Patterning / genetics; Body Patterning / physiology; Gastrointestinal Microbiome / genetics; Gastrointestinal Microbiome / physiology; Gene Expression Regulation, Developmental / genetics; Gene Expression Regulation, Developmental / physiology; Humans; Morphogenesis / genetics; Morphogenesis / physiology; Signal Transduction / genetics; Signal Transduction / physiology
TL;DR: New evidence is summarized challenging century-old ideas about the development of stomach and intestine laterality, challenging classical models of left-right asymmetric gut morphogenesis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: November 16, 2020

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