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Works (6)
Updated: April 6th, 2024 05:04
2024 journal article
Developmental regulation of cellular metabolism is required for intestinal elongation and rotation
DEVELOPMENT, 151(1).
author keywords: Intestine; Metabolism; Rotation; Electron transport chain; Elongation; Atrazine; Xenopus
TL;DR:
Roles for metabolism in gut morphogenesis are revealed and implicate defective gut tube elongation and/or metabolic perturbations in the etiology of intestinal malrotation.
(via Semantic Scholar)
journals.biologists.com (publisher PDF)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 22, 2024
2023 journal article
CTD tetramers: a new online tool that computationally links curated chemicals, genes, phenotypes, and diseases to inform molecular mechanisms for environmental health
TOXICOLOGICAL SCIENCES, 195(2), 155–168.
author keywords: database tool; chemical-disease pathway; molecular mechanisms; environmental health; knowledge gaps; adverse outcome pathway
Sources: Web Of Science, NC State University Libraries
Added: April 1, 2024
2023 journal article
Rare variants in <i>CAPN2</i> increase risk for isolated hypoplastic left heart syndrome
HUMAN GENETICS AND GENOMICS ADVANCES, 4(4).
TL;DR:
The findings show that iHLHS is typically not a Mendelian condition, demonstrate that CAPN2 variants increase risk of i HLHS, and identify a novel pathway involved in HLHS pathogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: October 16, 2023
2022 journal article
E-liquids and vanillin flavoring disrupts retinoic acid signaling and causes craniofacial defects in Xenopus embryos
DEVELOPMENTAL BIOLOGY, 481, 14–29.
author keywords: e-liquid; Vaping; Teratogen; Vanillin; Xenopus; Craniofacial
MeSH headings : Animals; Benzaldehydes / administration & dosage; Benzaldehydes / pharmacology; Craniofacial Abnormalities / chemically induced; Craniofacial Abnormalities / embryology; Embryo, Nonmammalian / embryology; Embryo, Nonmammalian / pathology; Flavoring Agents / adverse effects; Flavoring Agents / pharmacology; Signal Transduction / drug effects; Tobacco Products / toxicity; Tretinoin / metabolism; Xenopus laevis
TL;DR:
It is determined that e-liquid chemicals, in particular vanillin, can cause craniofacial defects potentially by dysregulating retinoic acid signaling, and the evaluation of vanillin and other such flavoring additives in e-liquids on mammalian development is warranted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: October 12, 2021
2021 journal article
Single-minded 2 is required for left-right asymmetric stomach morphogenesis
DEVELOPMENT, 148(17).
author keywords: right asymmetry; Stomach; Morphogenesis; Pitx2; Sim2; Down syndrome; Frog
MeSH headings : Animals; Anura; Basic Helix-Loop-Helix Transcription Factors / genetics; Basic Helix-Loop-Helix Transcription Factors / metabolism; Body Patterning; Embryo, Nonmammalian; Endoderm / embryology; Endoderm / metabolism; Gene Expression Regulation, Developmental; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Morphogenesis; Stomach / embryology; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR:
It is demonstrated that sim2 functions downstream of LR patterning cues to regulate key cellular properties and behaviors in the left stomach epithelium that drive asymmetric curvature, and has implications for dose-dependent roles of laterality factors in non-laterality-related birth defects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 27, 2021
2020 review
The twists and turns of left-right asymmetric gut morphogenesis
[Review of ]. DEVELOPMENT, 147(19).
author keywords: Gut tube; Intestine; Laterality; Left-right asymmetry; Morphogenesis; Stomach
MeSH headings : Animals; Body Patterning / genetics; Body Patterning / physiology; Gastrointestinal Microbiome / genetics; Gastrointestinal Microbiome / physiology; Gene Expression Regulation, Developmental / genetics; Gene Expression Regulation, Developmental / physiology; Humans; Morphogenesis / genetics; Morphogenesis / physiology; Signal Transduction / genetics; Signal Transduction / physiology
TL;DR:
New evidence is summarized challenging century-old ideas about the development of stomach and intestine laterality, challenging classical models of left-right asymmetric gut morphogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 16, 2020
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