Brent Wyatt

Works (10)

Updated: November 20th, 2025 13:33

2025 article

Integrating AI-powered text mining from PubTator into the manual curation workflow at the Comparative Toxicogenomics Database

Wiegers, T. C., Davis, A. P., Wiegers, J., Sciaky, D., Barkalow, F., Wyatt, B., … Mattingly, C. J. (2025, January 1). Database, Vol. 2025.

By: T. Wiegers n, A. Davis n, J. Wiegers n, D. Sciaky n, F. Barkalow n, B. Wyatt n, M. Strong n, R. McMorran n, S. Abrar n, C. Mattingly n 

MeSH headings : Toxicogenetics; Data Mining / methods; Data Curation / methods; Humans; Databases, Factual; Workflow; Databases, Genetic
topics (OpenAlex): Biomedical Text Mining and Ontologies; Genetics, Bioinformatics, and Biomedical Research; Bioinformatics and Genomic Networks; Semantic Web and Ontologies
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4. Quality Education (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 10, 2025

2025 article

Linking chemical data from the Comparative Toxicogenomics Database with adverse outcome pathways from the AOP-Wiki: a mechanistic data-oriented approach to help inform environmental health

Davis, A. P., Wiegers, T. C., Sciaky, D., Barkalow, F., Wyatt, B., Wiegers, J., … Mattingly, C. J. (2025, November 17). F1000Research.

By: A. Davis*, T. Wiegers*, D. Sciaky*, F. Barkalow*, B. Wyatt*, J. Wiegers*, R. McMorran*, S. Abrar* ...

topics (OpenAlex): Autism Spectrum Disorder Research; Health, Environment, Cognitive Aging; Click Chemistry and Applications
Sources: NC State University Libraries, NC State University Libraries
Added: November 19, 2025

2024 article

Comparative Toxicogenomics Database’s 20th anniversary: update 2025

Davis, A. P., Wiegers, T. C., Sciaky, D., Barkalow, F., Strong, M., Wyatt, B., … Mattingly, C. J. (2024, October 10). Nucleic Acids Research, Vol. 10.

By: A. Davis n, T. Wiegers n, D. Sciaky n, F. Barkalow n, M. Strong n, B. Wyatt n, J. Wiegers n, R. McMorran n, S. Abrar n, C. Mattingly n 

MeSH headings : Toxicogenetics; Humans; Software; Databases, Genetic; Anniversaries and Special Events; Databases, Factual; Data Curation
topics (OpenAlex): Biomedical Text Mining and Ontologies; Bioinformatics and Genomic Networks; Gene expression and cancer classification
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Sources: Web Of Science, NC State University Libraries
Added: October 21, 2024

2024 article

Developmental regulation of cellular metabolism is required for intestinal elongation and rotation

Grzymkowski, J. K., Chiu, Y.-C., Jima, D. D., Wyatt, B. H., Jayachandran, S., Stutts, W. L., & Nascone-Yoder, N. M. (2024, February 15). Development, Vol. 151.

By: J. Grzymkowski n, Y. Chiu, D. Jima n, B. Wyatt n, S. Jayachandran n, W. Stutts n , N. Nascone-Yoder n 

author keywords: Intestine; Metabolism; Rotation; Electron transport chain; Elongation; Atrazine; Xenopus
MeSH headings : Atrazine; Rotation; Herbicides / toxicity; Oxidation-Reduction; Gene Expression Profiling
topics (OpenAlex): Intestinal Malrotation and Obstruction Disorders; Metabolism and Genetic Disorders; Pediatric Hepatobiliary Diseases and Treatments
TL;DR: Roles for metabolism in gut morphogenesis are revealed and implicate defective gut tube elongation and/or metabolic perturbations in the etiology of intestinal malrotation. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 22, 2024

2024 article

Transforming environmental health datasets from the comparative toxicogenomics database into chord diagrams to visualize molecular mechanisms

Wyatt, B., Davis, A. P., Wiegers, T. C., Wiegers, J., Abrar, S., Sciaky, D., … Mattingly, C. J. (2024, July 22). Frontiers in Toxicology, Vol. 6.

By: B. Wyatt n, A. Davis n, T. Wiegers n, J. Wiegers n, S. Abrar n, D. Sciaky n, F. Barkalow n, M. Strong n, C. Mattingly n 

author keywords: data visualization; chord diagram; r; molecular mechanisms; environmental health; database; tetramers
topics (OpenAlex): Bioinformatics and Genomic Networks; Computational Drug Discovery Methods; Gene expression and cancer classification
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Sources: Web Of Science, NC State University Libraries
Added: August 19, 2024

2023 article

CTD tetramers: a new online tool that computationally links curated chemicals, genes, phenotypes, and diseases to inform molecular mechanisms for environmental health

Davis, A. P., Wiegers, T. C., Wiegers, J., Wyatt, B., Johnson, R. J., Sciaky, D., … Mattingly, C. J. (2023, July 21). Toxicological Sciences, Vol. 195, pp. 155–168.

By: A. Davis n, T. Wiegers n, J. Wiegers n, B. Wyatt n, R. Johnson n, D. Sciaky n, F. Barkalow n, M. Strong n, A. Planchart n , C. Mattingly n 

author keywords: database tool; chemical-disease pathway; molecular mechanisms; environmental health; knowledge gaps; adverse outcome pathway
MeSH headings : Male; Humans; Toxicogenetics; Databases, Factual; Environmental Health; Phenotype; Environmental Exposure
topics (OpenAlex): Health, Environment, Cognitive Aging; Bioinformatics and Genomic Networks; Computational Drug Discovery Methods
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Sources: Web Of Science, NC State University Libraries
Added: April 1, 2024

2023 article

Rare variants in CAPN2 increase risk for isolated hypoplastic left heart syndrome

Blue, E. E., White, J. J., Dush, M. K., Gordon, W. W., Wyatt, B. H., White, P., … Bamshad, M. J. (2023, August 11). Human Genetics and Genomics Advances, Vol. 4.

By: E. Blue *, J. White *, M. Dush n, W. Gordon *, B. Wyatt n, P. White *, C. Marvin*, E. Helle * ...

MeSH headings : Animals; Humans; Hypoplastic Left Heart Syndrome / genetics; Alleles; Aorta; Calpain / genetics; Cerebral Ventricles
topics (OpenAlex): Congenital heart defects research; RNA modifications and cancer; Cardiac Valve Diseases and Treatments
TL;DR: The findings show that iHLHS is typically not a Mendelian condition, demonstrate that CAPN2 variants increase risk of i HLHS, and identify a novel pathway involved in HLHS pathogenesis. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2023

2021 article

Single-minded 2 is required for left-right asymmetric stomach morphogenesis

Wyatt, B. H., Amin, N. M., Bagley, K., Wcisel, D. J., Dush, M. K., Yoder, J. A., & Nascone-Yoder, N. M. (2021, July 1). Development, Vol. 9.

By: B. Wyatt n, N. Amin n, K. Bagley n, D. Wcisel n, M. Dush n, J. Yoder n , N. Nascone-Yoder n 

author keywords: right asymmetry; Stomach; Morphogenesis; Pitx2; Sim2; Down syndrome; Frog
MeSH headings : Animals; Anura; Basic Helix-Loop-Helix Transcription Factors / genetics; Basic Helix-Loop-Helix Transcription Factors / metabolism; Body Patterning; Embryo, Nonmammalian; Endoderm / embryology; Endoderm / metabolism; Gene Expression Regulation, Developmental; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Morphogenesis; Stomach / embryology; Transcription Factors / genetics; Transcription Factors / metabolism
topics (OpenAlex): Congenital heart defects research; Developmental Biology and Gene Regulation
TL;DR: It is demonstrated that sim2 functions downstream of LR patterning cues to regulate key cellular properties and behaviors in the left stomach epithelium that drive asymmetric curvature, and has implications for dose-dependent roles of laterality factors in non-laterality-related birth defects. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 27, 2021

2021 article

E-liquids and vanillin flavoring disrupts retinoic acid signaling and causes craniofacial defects in Xenopus embryos

Dickinson, A. J. G., Turner, S. D., Wahl, S., Kennedy, A. E., Wyatt, B. H., & Howton, D. A. (2021, September 17). Developmental Biology.

By: A. Dickinson *, S. Turner *, S. Wahl *, A. Kennedy *, B. Wyatt n & D. Howton*

author keywords: e-liquid; Vaping; Teratogen; Vanillin; Xenopus; Craniofacial
MeSH headings : Animals; Benzaldehydes / administration & dosage; Benzaldehydes / pharmacology; Craniofacial Abnormalities / chemically induced; Craniofacial Abnormalities / embryology; Embryo, Nonmammalian / embryology; Embryo, Nonmammalian / pathology; Flavoring Agents / adverse effects; Flavoring Agents / pharmacology; Signal Transduction / drug effects; Tobacco Products / toxicity; Tretinoin / metabolism; Xenopus laevis
topics (OpenAlex): Cleft Lip and Palate Research; Congenital Ear and Nasal Anomalies; Prenatal Substance Exposure Effects
TL;DR: It is determined that e-liquid chemicals, in particular vanillin, can cause craniofacial defects potentially by dysregulating retinoic acid signaling, and the evaluation of vanillin and other such flavoring additives in e-liquids on mammalian development is warranted. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 12, 2021

2020 article

The twists and turns of left-right asymmetric gut morphogenesis

Grzymkowski, J., Wyatt, B., & Nascone-Yoder, N. (2020, October 1). Development, Vol. 147.

By: J. Grzymkowski n, B. Wyatt n & N. Nascone-Yoder n 

author keywords: Gut tube; Intestine; Laterality; Left-right asymmetry; Morphogenesis; Stomach
MeSH headings : Animals; Body Patterning / genetics; Body Patterning / physiology; Gastrointestinal Microbiome / genetics; Gastrointestinal Microbiome / physiology; Gene Expression Regulation, Developmental / genetics; Gene Expression Regulation, Developmental / physiology; Humans; Morphogenesis / genetics; Morphogenesis / physiology; Signal Transduction / genetics; Signal Transduction / physiology
topics (OpenAlex): Congenital heart defects research; Intestinal Malrotation and Obstruction Disorders; Congenital Heart Disease Studies
TL;DR: New evidence is summarized challenging century-old ideas about the development of stomach and intestine laterality, challenging classical models of left-right asymmetric gut morphogenesis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: November 16, 2020

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