Brent Hardin Wyatt

Works (6)

Updated: April 6th, 2024 05:04

2024 journal article

Developmental regulation of cellular metabolism is required for intestinal elongation and rotation


By: J. Grzymkowski n, Y. Chiu, D. Jima n, B. Wyatt n, S. Jayachandran n, W. Stutts n, N. Nascone-Yoder n

author keywords: Intestine; Metabolism; Rotation; Electron transport chain; Elongation; Atrazine; Xenopus
TL;DR: Roles for metabolism in gut morphogenesis are revealed and implicate defective gut tube elongation and/or metabolic perturbations in the etiology of intestinal malrotation. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 22, 2024

2023 journal article

CTD tetramers: a new online tool that computationally links curated chemicals, genes, phenotypes, and diseases to inform molecular mechanisms for environmental health


author keywords: database tool; chemical-disease pathway; molecular mechanisms; environmental health; knowledge gaps; adverse outcome pathway
Sources: Web Of Science, NC State University Libraries
Added: April 1, 2024

2023 journal article

Rare variants in <i>CAPN2</i> increase risk for isolated hypoplastic left heart syndrome


By: E. Blue*, J. White*, M. Dush n, W. Gordon*, B. Wyatt n, P. White*, C. Marvin*, E. Helle* ...

TL;DR: The findings show that iHLHS is typically not a Mendelian condition, demonstrate that CAPN2 variants increase risk of i HLHS, and identify a novel pathway involved in HLHS pathogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 16, 2023

2022 journal article

E-liquids and vanillin flavoring disrupts retinoic acid signaling and causes craniofacial defects in Xenopus embryos


By: A. Dickinson*, S. Turner*, S. Wahl*, A. Kennedy*, B. Wyatt n & D. Howton*

author keywords: e-liquid; Vaping; Teratogen; Vanillin; Xenopus; Craniofacial
MeSH headings : Animals; Benzaldehydes / administration & dosage; Benzaldehydes / pharmacology; Craniofacial Abnormalities / chemically induced; Craniofacial Abnormalities / embryology; Embryo, Nonmammalian / embryology; Embryo, Nonmammalian / pathology; Flavoring Agents / adverse effects; Flavoring Agents / pharmacology; Signal Transduction / drug effects; Tobacco Products / toxicity; Tretinoin / metabolism; Xenopus laevis
TL;DR: It is determined that e-liquid chemicals, in particular vanillin, can cause craniofacial defects potentially by dysregulating retinoic acid signaling, and the evaluation of vanillin and other such flavoring additives in e-liquids on mammalian development is warranted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 12, 2021

2021 journal article

Single-minded 2 is required for left-right asymmetric stomach morphogenesis


By: B. Wyatt n, N. Amin n, K. Bagley n, D. Wcisel n, M. Dush n, J. Yoder n, N. Nascone-Yoder n

author keywords: right asymmetry; Stomach; Morphogenesis; Pitx2; Sim2; Down syndrome; Frog
MeSH headings : Animals; Anura; Basic Helix-Loop-Helix Transcription Factors / genetics; Basic Helix-Loop-Helix Transcription Factors / metabolism; Body Patterning; Embryo, Nonmammalian; Endoderm / embryology; Endoderm / metabolism; Gene Expression Regulation, Developmental; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Morphogenesis; Stomach / embryology; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR: It is demonstrated that sim2 functions downstream of LR patterning cues to regulate key cellular properties and behaviors in the left stomach epithelium that drive asymmetric curvature, and has implications for dose-dependent roles of laterality factors in non-laterality-related birth defects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 27, 2021

2020 review

The twists and turns of left-right asymmetric gut morphogenesis

[Review of ]. DEVELOPMENT, 147(19).

By: J. Grzymkowski n, B. Wyatt n & N. Nascone-Yoder n

author keywords: Gut tube; Intestine; Laterality; Left-right asymmetry; Morphogenesis; Stomach
MeSH headings : Animals; Body Patterning / genetics; Body Patterning / physiology; Gastrointestinal Microbiome / genetics; Gastrointestinal Microbiome / physiology; Gene Expression Regulation, Developmental / genetics; Gene Expression Regulation, Developmental / physiology; Humans; Morphogenesis / genetics; Morphogenesis / physiology; Signal Transduction / genetics; Signal Transduction / physiology
TL;DR: New evidence is summarized challenging century-old ideas about the development of stomach and intestine laterality, challenging classical models of left-right asymmetric gut morphogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: November 16, 2020

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.