VapC toxins drive cellular dormancy under uranium stress for the extreme thermoacidophile Metallosphaera prunae
Mukherjee, A., Wheaton, G. H., Counts, J. A., Ijeomah, B., Desai, J., & Kelly, R. M. (2017, June 6). Environmental Microbiology, Vol. 19, pp. 2831–2842.
MeSH headings : Archaeal Proteins / genetics; Archaeal Proteins / metabolism; Bacterial Toxins / genetics; Bacterial Toxins / metabolism; Gene Expression Regulation, Bacterial / physiology; RNA Stability / physiology; Sulfolobaceae / genetics; Sulfolobaceae / growth & development; Sulfolobaceae / metabolism; Transcriptome; Uranium / metabolism
topics (OpenAlex): Radioactive element chemistry and processing; Metal Extraction and Bioleaching; Trace Elements in Health
TL;DR:
M. prunae utilizes VapC toxins for post-transcriptional regulation under uranium stress to enter a cellular dormant state, thereby providing an adaptive response to what would otherwise be a deleterious environmental perturbation.
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