Bryant Kane

College of Engineering

2024 journal article

Discovery of periplasmic solute binding proteins with specificity for ketone bodies: β-hydroxybutyrate binding proteins

PROTEIN SCIENCE, 33(7).

By: B. Kane n, J. Okuda-Shimazaki*, M. Andrews n, J. Kerrigan n, K. Murphy n & K. Sode n

author keywords: solute binding protein; periplasmic binding protein; beta-hydroxybutyrate; molecular recognition; poly(hydroxyalkanoate); AlphaFold2; molecular dynamics
Sources: Web Of Science, ORCID
Added: June 15, 2024

2022 journal article

Development of an electrochemical impedance spectroscopy based biosensor for detection of ubiquitin C-Terminal hydrolase L1

BIOSENSORS & BIOELECTRONICS, 208.

By: J. Lee n, B. Kane n, M. Khanwalker n & K. Sode n

author keywords: Traumatic brain injury; Ubiquitin C-Terminal hydrolase L1 (UCH-L1); Electrochemical impedance spectroscopy; Point-of-care testing; Immunosensor
MeSH headings : Biomarkers; Biosensing Techniques; Brain Injuries, Traumatic / diagnosis; Dielectric Spectroscopy; Humans; Ubiquitin Thiolesterase
TL;DR: This system could detect UCH-L1 within 5 min, without a washing step nor bound/free separation, and had resolution across concentrations ranging from 1 pM to 1000 pM within an artificial serum sample, which makes this platform an attractive candidate for scale-up as a device for rapid, on-site detection of TBI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 30, 2022

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