Bryant Kane

College of Engineering

2022 journal article

Development of an electrochemical impedance spectroscopy based biosensor for detection of ubiquitin C-Terminal hydrolase L1


By: J. Lee n, B. Kane n, M. Khanwalker n & K. Sode n

author keywords: Traumatic brain injury; Ubiquitin C-Terminal hydrolase L1 (UCH-L1); Electrochemical impedance spectroscopy; Point-of-care testing; Immunosensor
MeSH headings : Biomarkers; Biosensing Techniques; Brain Injuries, Traumatic / diagnosis; Dielectric Spectroscopy; Humans; Ubiquitin Thiolesterase
TL;DR: This system could detect UCH-L1 within 5 min, without a washing step nor bound/free separation, and had resolution across concentrations ranging from 1 pM to 1000 pM within an artificial serum sample, which makes this platform an attractive candidate for scale-up as a device for rapid, on-site detection of TBI. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 30, 2022

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