Bryant Kane

College of Engineering

Works (3)

Updated: May 10th, 2025 05:04

2025 article

Expanding the bioanalytical application of β‐hydroxybutyrate binding proteins through characterization of their metabolite interactions and site‐directed mutagenesis

Kane, B. J., Murphy, K. V., & Sode, K. (2025, April 22). Protein Science, Vol. 34.

By: B. Kane n, K. Murphy n & K. Sode n 

author keywords: biosensor; diabetic ketoacidosis; ketone; nano differential scanning fluorimetry; nanoDSF; site-directed mutagenesis; solute-binding proteins; beta-hydroxybutyrate binding proteins
MeSH headings : 3-Hydroxybutyric Acid / metabolism; 3-Hydroxybutyric Acid / chemistry; Mutagenesis, Site-Directed; Bacterial Proteins / genetics; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Periplasmic Binding Proteins / chemistry; Periplasmic Binding Proteins / genetics; Periplasmic Binding Proteins / metabolism; Escherichia coli / genetics; Escherichia coli / metabolism; Protein Binding
topics (OpenAlex): Metabolomics and Mass Spectrometry Studies; Diet and metabolism studies; Enzyme Structure and Function
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 22, 2025

2024 article

Discovery of periplasmic solute binding proteins with specificity for ketone bodies: β‐hydroxybutyrate binding proteins

Kane, B. J., Okuda‐Shimazaki, J., Andrews, M. M., Kerrigan, J. A., Murphy, K. V., & Sode, K. (2024, June 12). Protein Science, Vol. 33.

By: B. Kane n, J. Okuda‐Shimazaki *, M. Andrews n, J. Kerrigan n, K. Murphy n & K. Sode n 

author keywords: solute binding protein; periplasmic binding protein; beta-hydroxybutyrate; molecular recognition; poly(hydroxyalkanoate); AlphaFold2; molecular dynamics
MeSH headings : 3-Hydroxybutyric Acid / metabolism; 3-Hydroxybutyric Acid / chemistry; Bacterial Proteins / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Periplasmic Binding Proteins / metabolism; Periplasmic Binding Proteins / chemistry; Periplasmic Binding Proteins / genetics; Escherichia coli / metabolism; Escherichia coli / genetics; Ketone Bodies / metabolism; Ketone Bodies / chemistry
topics (OpenAlex): Enzyme Structure and Function; Protein Structure and Dynamics; Microbial Metabolic Engineering and Bioproduction
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 15, 2024

2022 article

Development of an electrochemical impedance spectroscopy based biosensor for detection of ubiquitin C-Terminal hydrolase L1

Lee, J., Kane, B. J., Khanwalker, M., & Sode, K. (2022, March 29). Biosensors and Bioelectronics, Vol. 208, p. 114232.

By: J. Lee  n, B. Kane n, M. Khanwalker n & K. Sode n 

author keywords: Traumatic brain injury; Ubiquitin C-Terminal hydrolase L1 (UCH-L1); Electrochemical impedance spectroscopy; Point-of-care testing; Immunosensor
MeSH headings : Biomarkers; Biosensing Techniques; Brain Injuries, Traumatic / diagnosis; Dielectric Spectroscopy; Humans; Ubiquitin Thiolesterase
topics (OpenAlex): Neonatal Respiratory Health Research; Mass Spectrometry Techniques and Applications; Advanced biosensing and bioanalysis techniques
TL;DR: This system could detect UCH-L1 within 5 min, without a washing step nor bound/free separation, and had resolution across concentrations ranging from 1 pM to 1000 pM within an artificial serum sample, which makes this platform an attractive candidate for scale-up as a device for rapid, on-site detection of TBI. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 30, 2022

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