Bhanu P. Koppolu

Works (3)

Updated: August 7th, 2023 21:17

2019 journal article

ULTRASOUND-STIMULATED PHASE-CHANGE CONTRAST AGENTS FOR TRANSEPITHELIAL DELIVERY OF MACROMOLECULES, TOWARD GASTROINTESTINAL DRUG DELIVERY

ULTRASOUND IN MEDICINE AND BIOLOGY, 45(7), 1762–1776.

By: S. Fix *, B. Koppolu n, A. Novell *, J. Hopkins n, T. Kierski  n, D. Zaharoff n, P. Dayton n, V. Papadopoulou  n

author keywords: Ultrasound; Transepithelial delivery; Acoustic droplet vaporization; Phase-change contrast agents; Nanodroplet
MeSH headings : Cells, Cultured; Contrast Media; Dextrans / administration & dosage; Drug Delivery Systems / methods; Fluorescein-5-isothiocyanate / administration & dosage; Fluorescein-5-isothiocyanate / analogs & derivatives; Gastrointestinal Agents / administration & dosage; Humans; Image Enhancement / methods; In Vitro Techniques; Ultrasonography / methods
TL;DR: It is demonstrated that ultrasound-stimulated phase change contrast agents (PCCAs) can transiently disrupt confluent colorectal adenocarcinoma monolayers and improve the transepithelial transport of a macromolecular model drug. (via Semantic Scholar)
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Source: Web Of Science
Added: June 24, 2019

2017 journal article

Modulation of Interleukin-12 activity in the presence of heparin

SCIENTIFIC REPORTS, 7.

By: S. Jayanthi *, B. Koppolu*, K. Nguyen *, S. Smith*, B. Felber *, T. Kumar *, D. Zaharoff n

MeSH headings : Biophysical Phenomena; Cell Line; Chromatography, Gel; Flow Cytometry; Heparin / metabolism; Heparitin Sulfate / metabolism; Humans; Immunologic Factors / metabolism; Interleukin-12 / chemistry; Interleukin-12 / metabolism; Interleukin-12 Subunit p35; Protein Binding; Protein Conformation / drug effects; Protein Multimerization / drug effects; Scattering, Small Angle
TL;DR: Results of this study demonstrate a new role for heparin in modulating the biological activity of IL-12, and Heparin modestly protected hIL-12 from proteolytic degradation, however, this was not a likely mechanism for increased cytokine activity in vitro. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 journal article

Immunological mechanisms of intravesical chitosan/interleukin-12 immunotherapy against murine bladder cancer

ONCOIMMUNOLOGY, 6(1).

By: S. Smith n, J. Baltz*, B. Koppolu n, S. Ravindranathan *, K. Nguyen * & D. Zaharoff n

author keywords: BCG; bladder cancer; chitosan; immunotherapy; interleukin-12; intratumoral; intravesical; MDSC; TILS; TReg
TL;DR: The ability of properly delivered interleukin-12-based therapies to engage adaptive immunity within the tumor itself as well as throughout the body is demonstrated and the case for clinical translation of chitosan/interleuk in-12 as an intravesical treatment for bladder cancer is strengthened. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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