Bhanu P. Koppolu

Works (3)

Updated: August 7th, 2023 21:17

2019 article

Ultrasound-Stimulated Phase-Change Contrast Agents for Transepithelial Delivery of Macromolecules, Toward Gastrointestinal Drug Delivery

Fix, S. M., Koppolu, B. P., Novell, A., Hopkins, J., Kierski, T. M., Zaharoff, D. A., … Papadopoulou, V. (2019, April 16). Ultrasound in Medicine & Biology.

By: S. Fix *, B. Koppolu n, A. Novell *, J. Hopkins n, T. Kierski  n, D. Zaharoff n, P. Dayton n, V. Papadopoulou  n

author keywords: Ultrasound; Transepithelial delivery; Acoustic droplet vaporization; Phase-change contrast agents; Nanodroplet
MeSH headings : Cells, Cultured; Contrast Media; Dextrans / administration & dosage; Drug Delivery Systems / methods; Fluorescein-5-isothiocyanate / administration & dosage; Fluorescein-5-isothiocyanate / analogs & derivatives; Gastrointestinal Agents / administration & dosage; Humans; Image Enhancement / methods; In Vitro Techniques; Ultrasonography / methods
topics (OpenAlex): Ultrasound and Hyperthermia Applications; Ultrasound and Cavitation Phenomena; Advancements in Transdermal Drug Delivery
TL;DR: It is demonstrated that ultrasound-stimulated phase change contrast agents (PCCAs) can transiently disrupt confluent colorectal adenocarcinoma monolayers and improve the transepithelial transport of a macromolecular model drug. (via Semantic Scholar)
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7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: June 24, 2019

2017 article

Modulation of Interleukin-12 activity in the presence of heparin

Jayanthi, S., Koppolu, B., Nguyen, K. G., Smith, S. G., Felber, B. K., Kumar, T. K. S., & Zaharoff, D. A. (2017, July 7). Scientific Reports.

By: S. Jayanthi *, B. Koppolu n, K. Nguyen *, S. Smith n, B. Felber *, T. Kumar *, D. Zaharoff n

MeSH headings : Biophysical Phenomena; Cell Line; Chromatography, Gel; Flow Cytometry; Heparin / metabolism; Heparitin Sulfate / metabolism; Humans; Immunologic Factors / metabolism; Interleukin-12 / chemistry; Interleukin-12 / metabolism; Interleukin-12 Subunit p35; Protein Binding; Protein Conformation / drug effects; Protein Multimerization / drug effects; Scattering, Small Angle
topics (OpenAlex): Viral Infectious Diseases and Gene Expression in Insects; Monoclonal and Polyclonal Antibodies Research; Glycosylation and Glycoproteins Research
TL;DR: Results of this study demonstrate a new role for heparin in modulating the biological activity of IL-12, and Heparin modestly protected hIL-12 from proteolytic degradation, however, this was not a likely mechanism for increased cytokine activity in vitro. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 article

Immunological mechanisms of intravesical chitosan/interleukin-12 immunotherapy against murine bladder cancer

Smith, S. G., Baltz, J. L., Koppolu, B. P., Ravindranathan, S., Nguyen, K., & Zaharoff, D. A. (2016, November 18). OncoImmunology.

By: S. Smith n, J. Baltz*, B. Koppolu n, S. Ravindranathan *, K. Nguyen * & D. Zaharoff n

author keywords: BCG; bladder cancer; chitosan; immunotherapy; interleukin-12; intratumoral; intravesical; MDSC; TILS; TReg
topics (OpenAlex): Bladder and Urothelial Cancer Treatments; Immune Cell Function and Interaction; Immunotherapy and Immune Responses
TL;DR: The ability of properly delivered interleukin-12-based therapies to engage adaptive immunity within the tumor itself as well as throughout the body is demonstrated and the case for clinical translation of chitosan/interleuk in-12 as an intravesical treatment for bladder cancer is strengthened. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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