Works (8)

Updated: July 5th, 2023 15:45

2017 journal article

Fluorinated polymer–photosensitizer conjugates enable improved generation of ROS for anticancer photodynamic therapy

Polymer Chemistry, 8(20), 3195–3202.

By: J. Wallat*, K. Wek*, P. Chariou*, B. Carpenter n, R. Ghiladi n, N. Steinmetz*, J. Pokorski*

TL;DR: Covalent conjugation of the photosensitizer to a fluorous polymer demonstrated enhanced singlet oxygen production, showing the potential to improve the PDT efficacy in hypoxic tumor environments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2016 journal article

High Aspect Ratio Nanotubes Formed by Tobacco Mosaic Virus for Delivery of Photodynamic Agents Targeting Melanoma

ACS Biomaterials Science & Engineering, 2(5), 838–844.

By: K. Lee, B. Carpenter n, A. Wen, R. Ghiladi n & N. Steinmetz

Contributors: K. Lee, B. Carpenter n, A. Wen, R. Ghiladi n & N. Steinmetz

author keywords: viral nanoparticles; tobacco mosaic virus; photodynamic therapy; melanoma
TL;DR: The delivery of a porphyrin-based photosensitizer encapsulated within a plant viral nanoparticle made use of the hollow, high aspect ratio nanotubes formed by the nucleoprotein components of tobacco mosaic virus to encapsulate the drug for delivery and targeting of cancer cells. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2016 journal article

Utilizing Viral Nanoparticle/Dendron Hybrid Conjugates in Photodynamic Therapy for Dual Delivery to Macrophages and Cancer Cells

Bioconjugate Chemistry, 27(5), 1227–1235.

By: A. Wen, K. Lee, P. Cao, K. Pangilinan, B. Carpenter n, P. Lam, F. Veliz, R. Ghiladi n, R. Advincula, N. Steinmetz

Contributors: A. Wen, K. Lee, P. Cao, K. Pangilinan, B. Carpenter n, P. Lam, F. Veliz, R. Ghiladi n, R. Advincula, N. Steinmetz

MeSH headings : Animals; Comovirus / chemistry; Dendrimers / chemistry; Drug Carriers / chemistry; Macrophages / metabolism; Melanoma, Experimental / pathology; Mice; Nanoparticles / chemistry; Photochemotherapy; Photosensitizing Agents / chemistry; Photosensitizing Agents / metabolism; RAW 264.7 Cells
TL;DR: Overall, effective elimination of both macrophage and tumor cells at low micromolar concentrations of the photosensitizer when delivered with the CPMV bioconjugate is demonstrated, thereby potentially improving melanoma treatment. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2015 journal article

Antiviral, antifungal and antibacterial activities of a BODIPY-based photosensitizer

Molecules, 20(6), 10604–10621.

By: B. Carpenter, X. Situ, F. Scholle, J. Bartelmess, W. Weare & R. Ghiladi

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Dendritic near-IR absorbing zinc phthalocyanines for antimicrobial photodynamic therapy

Tetrahedron Letters, 56(23), 3541–3545.

By: D. Muli*, B. Carpenter n, M. Mayukh*, R. Ghiladi n & D. McGrath*

Contributors: D. Muli*, B. Carpenter n, M. Mayukh*, R. Ghiladi n & D. McGrath*

author keywords: Non-aggregated; Water soluble; Click chemistry; Singlet oxygen; Methylene blue
TL;DR: Both ZnPcs showed negligible dark toxicity on bacteria and yeast with 10 μM 1a and 1b, and aggregation studies indicate that non-peripherally substituted 1b is significantly less aggregated in aqueous media than peripherally substitution 1a . (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2015 journal article

Synthesis, Characterization, and Antimicrobial Efficacy of Photomicrobicidal Cellulose Paper

BIOMACROMOLECULES, 16(8), 2482–2492.

Contributors: B. Carpenter*, F. Scholle*, H. Sadeghifar*, A. Francis*, J. Boltersdorf*, W. Weare*, D. Argyropoulos*, P. Maggard*, R. Ghiladi*

MeSH headings : Anti-Infective Agents / administration & dosage; Anti-Infective Agents / chemical synthesis; Anti-Infective Agents / chemistry; Cellulose / administration & dosage; Cellulose / chemical synthesis; Cellulose / chemistry; Enterococcus faecium / drug effects; Humans; Klebsiella pneumoniae / drug effects; Light; Microbial Sensitivity Tests; Paper; Photosensitizing Agents / chemical synthesis; Photosensitizing Agents / chemistry; Porphyrins / administration & dosage; Porphyrins / chemical synthesis; Porphyrins / chemistry; Pseudomonas aeruginosa / drug effects; Staphylococcus aureus / drug effects
TL;DR: The results demonstrate the potential of cellulose materials to serve as scalable scaffolds for anti-infective or self-sterilizing materials against both bacteria and viruses when employing a photodynamic inactivation mode of action. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 article

Porphyrin-Cellulose Nanocrystals: A Photobactericidal Material that Exhibits Broad Spectrum Antimicrobial Activity (vol 88, pg 495, 2012)

PHOTOCHEMISTRY AND PHOTOBIOLOGY, Vol. 88, pp. 1034–1034.

By: B. Carpenter n, E. Feese n, H. Sadeghifar n, D. Argyropoulos n & R. Ghiladi n

Contributors: B. Carpenter n, E. Feese n, H. Sadeghifar n, D. Argyropoulos n & R. Ghiladi n

Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Porphyrin-Cellulose Nanocrystals: A Photobactericidal Material that Exhibits Broad Spectrum Antimicrobial Activity†

Photochemistry and Photobiology, 88(3), 527–536.

By: B. Carpenter n, E. Feese n, H. Sadeghifar n, D. Argyropoulos n & R. Ghiladi n

Contributors: B. Carpenter n, E. Feese n, H. Sadeghifar n, D. Argyropoulos n & R. Ghiladi n

MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / pharmacology; Cellulose / chemistry; Drug Resistance, Microbial; Microscopy, Confocal; Microscopy, Fluorescence; Nanoparticles; Photochemotherapy; Porphyrins / chemistry; Spectrophotometry, Ultraviolet; Staphylococcus aureus / drug effects
TL;DR: Research into alternative materials such as CNC‐Por may lead to their application in hospitals and healthcare‐related industries wherein novel materials with the capability of reducing the rates of transmission of a wide range of bacteria, particularly antibiotic resistant strains, are desired. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

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