Works (5)

Updated: July 7th, 2023 21:18

2019 journal article

Identification of Anti-Mycobacterial Biofilm Agents Based on the 2-Aminoimidazole Scaffold

CHEMMEDCHEM, 14(9), 927–937.

By: T. Nguyen n, B. Minrovic*, R. Melander* & C. Melander

author keywords: 2-aminoimidazoles; biofilms; mycobacteria; synergy; tuberculosis
MeSH headings : Animals; Antitubercular Agents / chemistry; Antitubercular Agents / pharmacology; Biofilms / drug effects; Imidazoles / chemistry; Male; Mice; Microsomes / drug effects; Microsomes / metabolism; Mycobacterium tuberculosis / drug effects
Source: Web Of Science
Added: July 1, 2019

2019 journal article

Small Molecule Potentiation of Gram-Positive Selective Antibiotics against Acinetobacter baumannii


By: S. Martin*, R. Melander*, C. Brackett n, A. Scott*, C. Chandler*, C. Nguyen n, B. Minrovic*, S. Harrill n ...

author keywords: antibiotic adjuvant; antibiotic resistance; Acinetobacter baumannii; macrolide antibiotics; glycopeptide antibiotics; lipopolysaccharide
MeSH headings : Acinetobacter Infections / drug therapy; Acinetobacter baumannii / drug effects; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacology; Bacterial Outer Membrane / drug effects; Disease Models, Animal; Drug Resistance, Multiple, Bacterial / drug effects; Drug Synergism; Glycopeptides / administration & dosage; Glycopeptides / pharmacology; Macrolides / administration & dosage; Macrolides / pharmacology; Microbial Sensitivity Tests; Moths; Small Molecule Libraries / administration & dosage; Small Molecule Libraries / pharmacology
Source: Web Of Science
Added: August 5, 2019

2019 journal article

Using Small-Molecule Adjuvants to Repurpose Azithromycin for Use against Pseudomonas aeruginosa


By: V. Hubble*, B. Hubbard n, B. Minrovic*, R. Melander* & C. Melander

author keywords: antibiotic resistance; antibiotic adjuvant; cystic fibrosis; Pseudomonas aeruginosa
MeSH headings : Adjuvants, Pharmaceutic / chemistry; Animals; Anti-Bacterial Agents / pharmacology; Azithromycin / pharmacology; Benzimidazoles / chemistry; Benzimidazoles / pharmacology; Cystic Fibrosis / drug therapy; Cystic Fibrosis / microbiology; Disease Models, Animal; Drug Repositioning; Larva / drug effects; Larva / microbiology; Microbial Sensitivity Tests; Moths / drug effects; Moths / microbiology; Pseudomonas aeruginosa / drug effects; Respiratory Tract Infections / drug therapy
Source: Web Of Science
Added: April 20, 2020

2018 journal article

Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp.


By: M. Milton*, B. Minrovic n, D. Harris*, B. Kang*, D. Jung*, C. Lewis n, R. Thompson*, R. Melander n ...

author keywords: biofilms; antibiotic resistance; two-component systems; response regulators; Acinetobacter baumannii; Francisella
Source: Web Of Science
Added: January 28, 2019

2017 journal article

The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to beta-Lactam Antibiotics in a Pattern Distinct from beta-Lactamase Inhibitors


By: T. Nguyen n, M. Blackledge*, E. Lindsey n, B. Minrovic n, D. Ackart*, A. Jeon*, A. Obregon-Henao*, R. Melander n, R. Basaraba*, C. Melander

author keywords: aminobenzimidazoles; antibiotic resistance; medicinal chemistry; tuberculosis
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Benzimidazoles / chemistry; Benzimidazoles / pharmacology; Drug Discovery; Lactams / chemical synthesis; Lactams / chemistry; Lactams / pharmacology; Molecular Structure; Mycobacterium smegmatis / drug effects; Mycobacterium smegmatis / enzymology; Mycobacterium tuberculosis / drug effects; Mycobacterium tuberculosis / enzymology; beta-Lactamase Inhibitors / chemical synthesis; beta-Lactamase Inhibitors / chemistry; beta-Lactamase Inhibitors / pharmacology; beta-Lactamases / metabolism
Source: Web Of Science
Added: August 6, 2018