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Works (55)
Updated: July 26th, 2023 21:17
2023 journal article
Laminin switches terminal differentiation fate of human trophoblast stem cells under chemically defined culture conditions
JOURNAL OF BIOLOGICAL CHEMISTRY, 299(5).
MeSH headings : Humans; Cell Differentiation / drug effects; Colforsin / pharmacology; Colforsin / metabolism; HLA-G Antigens / genetics; HLA-G Antigens / metabolism; Laminin / pharmacology; Stem Cells / cytology; Stem Cells / drug effects; Transforming Growth Factor beta / metabolism; Trophoblasts / cytology; Trophoblasts / metabolism; Culture Media / chemistry; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Gene Expression Regulation, Developmental / drug effects; Cytological Techniques / methods
www.ncbi.nlm.nih.gov (repository)
Sources: Web Of Science, ORCID
Added: July 3, 2023
2022 article
Experimental and Analytical Framework for "Mix-and-Read" Assays Based on Split Luciferase
McArthur, N., Cruz-Teran, C., Thatavarty, A., Reeves, G. T., & Rao, B. M. (2022, July 1). ACS OMEGA.
Source: Web Of Science
Added: July 26, 2022
2022 journal article
Experimental and Analytical Framework for "Mix-and-Read" Assays Based on Split Luciferase
ACS OMEGA, 7(28), 24551–24560.
Source: Web Of Science
Added: August 8, 2022
2022 journal article
Modified Histone Peptides Linked to Magnetic Beads Reduce Binding Specificity
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(3).
author keywords: yeast surface display; histone post-translational modifications; affinity reagents; protein engineering; chromodomain; binder; reader; antibody; epigenome engineering; synthetic biology
MeSH headings : HEK293 Cells; Histone Code; Histones / metabolism; Humans; Jurkat Cells; K562 Cells; Protein Array Analysis; Protein Binding; Protein Engineering; Protein Processing, Post-Translational; Saccharomyces cerevisiae
Source: Web Of Science
Added: February 21, 2022
2021 journal article
Mapping the residue specificities of epigenome enzymes by yeast surface display
CELL CHEMICAL BIOLOGY, 28(12), 1772-+.
MeSH headings : E1A-Associated p300 Protein / genetics; E1A-Associated p300 Protein / metabolism; Epigenome / genetics; Humans; Saccharomyces cerevisiae / metabolism
Source: Web Of Science
Added: January 3, 2022
2021 journal article
Quantitative Yeast-Yeast Two Hybrid for the Discovery and Binding Affinity Estimation of Protein-Protein Interactions
ACS SYNTHETIC BIOLOGY, 10(3), 505–514.
author keywords: yeast two-hybrid; protein-protein interactions; protein engineering; yeast surface display; post-translational modification; cDNA library
MeSH headings : Gene Library; Genes, Reporter; Protein Binding; Protein Domains; Protein Interaction Maps; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Smad3 Protein / chemistry; Smad3 Protein / metabolism; Transcription Factors / chemistry; Transcription Factors / metabolism; Two-Hybrid System Techniques
Sources: Web Of Science, ORCID
Added: March 29, 2021
2021 journal article
Screening of Yeast Display Libraries of Enzymatically Treated Peptides to Discover Macrocyclic Peptide Ligands
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(4).
author keywords: yeast display library; cyclic peptide; Yes Associated Protein (YAP) 65; WW domain; transglutaminase
MeSH headings : Adaptor Proteins, Signal Transducing / chemistry; Adaptor Proteins, Signal Transducing / metabolism; Albumins / metabolism; Binding Sites; Combinatorial Chemistry Techniques; Endoplasmic Reticulum / metabolism; Flow Cytometry; Ligands; Muramidase / metabolism; Peptides, Cyclic / isolation & purification; Peptides, Cyclic / pharmacology; Protein Binding; Protein Engineering / methods; Transcription Factors / chemistry; Transcription Factors / metabolism; Transglutaminases / metabolism; YAP-Signaling Proteins; Yeasts / genetics; Yeasts / growth & development
Sources: Web Of Science, ORCID
Added: March 22, 2021
2021 journal article
Two distinct trophectoderm lineage stem cells from human pluripotent stem cells
JOURNAL OF BIOLOGICAL CHEMISTRY, 296.
MeSH headings : CDX2 Transcription Factor / metabolism; Cell Culture Techniques; Cell Differentiation; Cell Lineage; Culture Media; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Female; Humans; Placenta / cytology; Placenta / metabolism; Pluripotent Stem Cells / cytology; Pluripotent Stem Cells / metabolism; Pregnancy; Trophoblasts / cytology; Trophoblasts / metabolism
Sources: Web Of Science, ORCID
Added: September 7, 2021
2020 journal article
A Fyn biosensor reveals pulsatile, spatially localized kinase activity and signaling crosstalk in live mammalian cells
ELIFE, 9.
MeSH headings : Animals; Biosensing Techniques; Cell Line; Cell Physiological Phenomena / genetics; Fluorescence Resonance Energy Transfer; Fluorescent Dyes / metabolism; HEK293 Cells; Humans; Magnetic Resonance Spectroscopy; Mice; Phosphorylation / genetics; Proto-Oncogene Proteins c-fyn / chemistry; Proto-Oncogene Proteins c-fyn / genetics; Proto-Oncogene Proteins c-fyn / metabolism; Signal Transduction / genetics; Yeasts / genetics
Source: Web Of Science
Added: February 27, 2020
2020 journal article
Discovery of Membrane-Permeating Cyclic Peptides via mRNA Display
BIOCONJUGATE CHEMISTRY, 31(10), 2325–2338.
MeSH headings : Animals; Cell Line; Cell-Penetrating Peptides / chemistry; Cell-Penetrating Peptides / genetics; Cell-Penetrating Peptides / pharmacokinetics; Drosophila melanogaster / embryology; Gene Library; Humans; Mice; Models, Molecular; NIH 3T3 Cells; Peptides, Cyclic / chemistry; Peptides, Cyclic / genetics; Peptides, Cyclic / pharmacokinetics; Permeability; RNA, Messenger / genetics
Sources: Web Of Science, ORCID
Added: December 21, 2020
2020 journal article
Genetically encoded live-cell sensor for tyrosinated microtubules
JOURNAL OF CELL BIOLOGY, 219(10).
MeSH headings : Colchicine / pharmacology; Cytoskeleton / drug effects; Cytoskeleton / genetics; HEK293 Cells; Humans; Microtubule-Associated Proteins / genetics; Microtubules / genetics; Nocodazole / pharmacology; Protein Processing, Post-Translational / drug effects; Protein Processing, Post-Translational / genetics; Tubulin / genetics; Tyrosine / drug effects; Tyrosine / genetics; Vincristine / pharmacology
Source: Web Of Science
Added: November 9, 2020
2020 journal article
Isolation of Chemically Cyclized Peptide Binders Using Yeast Surface Display
ACS COMBINATORIAL SCIENCE, 22(10), 519–532.
author keywords: cyclic peptides; interleukin-17 (IL-17); library screening; yeast-display libraries; affinity ligands
MeSH headings : Biophysical Phenomena; Cell Membrane / chemistry; Cyclization; Flow Cytometry; Humans; Interleukin-17 / chemistry; Molecular Docking Simulation; Peptide Library; Peptides, Cyclic / isolation & purification; Protein Binding; Protein Conformation; Protein Engineering; Recombinant Proteins / chemistry; Saccharomyces cerevisiae / chemistry; Saccharomyces cerevisiae / ultrastructure; Structure-Activity Relationship; Surface Properties
Sources: Web Of Science, ORCID
Added: November 9, 2020
2020 review
Past, Present, and Future of Affinity-based Cell Separation Technologies
[Review of ]. ACTA BIOMATERIALIA, 112, 29–51.
author keywords: Cell purification; Immunoaffinity; MACS; FACS; Microfluidics
MeSH headings : Cell Separation; Chromatography, Affinity; Flow Cytometry; Ligands; Regenerative Medicine
Sources: Web Of Science, ORCID
Added: August 3, 2020
2020 article
Simultaneous Soluble Secretion and Surface Display of Proteins in Saccharomyces cerevisiae Using Inefficient Ribosomal Skipping
GENOTYPE PHENOTYPE COUPLING: METHODS AND PROTOCOLS, Vol. 2070, pp. 321–334.
author keywords: Yeast surface display; Self-cleaving peptides; 2A peptides; Secretion; Ribosomal skipping; Sso7d
MeSH headings : Peptide Library; Peptides / metabolism; Protein Biosynthesis; Recombinant Proteins / biosynthesis; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Ribosomes / metabolism; Saccharomyces cerevisiae / chemistry; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism
Source: Web Of Science
Added: September 7, 2020
2020 journal article
Use of Target-Displaying Magnetized Yeast in Screening mRNA-Display Peptide Libraries to Identify Ligands
ACS COMBINATORIAL SCIENCE, 22(12), 738–744.
author keywords: yeast surface display; yeast magnetization; peptide ligands; mRNA-display library; ligand discovery
MeSH headings : Ligands; Mitochondrial Membrane Transport Proteins / chemistry; Models, Molecular; Peptide Library; RNA, Messenger / chemistry; Saccharomyces cerevisiae / chemistry; Saccharomyces cerevisiae Proteins / chemistry; Transcription Factors / chemistry
Sources: Web Of Science, ORCID
Added: January 11, 2021
2019 article
DERIVATION OF HUMAN TROPHOBLAST STEM CELLS FROM HUMAN PLURIPOTENT STEM CELLS
Mischler, A., Karakis, V., San Miguel, A., & Rao, B. (2019, August). PLACENTA, Vol. 83, pp. E59–E59.
Sources: Web Of Science, ORCID
Added: April 20, 2020
2019 journal article
Design and evaluation of engineered protein biosensors for live-cell imaging of EGFR phosphorylation
SCIENCE SIGNALING, 12(584).
MeSH headings : Animals; Biosensing Techniques; Cell Line; Endocytosis; ErbB Receptors / genetics; ErbB Receptors / metabolism; Mice; Microscopy, Fluorescence; Phospholipase C gamma / genetics; Phospholipase C gamma / metabolism; Phosphorylation / genetics; src Homology Domains
Sources: Web Of Science, ORCID
Added: June 24, 2019
2019 journal article
Screening Yeast Display Libraries against Magnetized Yeast Cell Targets Enables Efficient Isolation of Membrane Protein Binders
ACS COMBINATORIAL SCIENCE, 21(12), 817–832.
author keywords: yeast magnetization; combinatorial library screening; ligand discovery; yeast surface display; membrane protein; Sso7d; nanobody
MeSH headings : Combinatorial Chemistry Techniques; Drug Evaluation, Preclinical; Ferric Compounds / chemistry; Ferric Compounds / pharmacology; Magnetic Phenomena; Mitochondria / drug effects; Mitochondria / metabolism; Mitochondrial Membrane Transport Proteins / antagonists & inhibitors; Mitochondrial Membrane Transport Proteins / isolation & purification; Mitochondrial Membrane Transport Proteins / metabolism; Nanoparticles / chemistry; Protein Binding / drug effects; Saccharomyces cerevisiae / cytology; Saccharomyces cerevisiae / drug effects; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins / antagonists & inhibitors; Saccharomyces cerevisiae Proteins / isolation & purification; Saccharomyces cerevisiae Proteins / metabolism; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology
Sources: Web Of Science, ORCID
Added: December 30, 2019
2018 journal article
An Engineered Sso7d Variant Enables Efficient Magnetization of Yeast Cells
ACS COMBINATORIAL SCIENCE, 20(10), 579–584.
author keywords: Sso7d; magnetization; cell capture; yeast surface display; magnetic separation
MeSH headings : Amino Acid Sequence; Archaeal Proteins / genetics; Archaeal Proteins / metabolism; Cell Membrane / metabolism; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Magnetic Phenomena; Magnetite Nanoparticles / chemistry; Mutation; Peptide Library; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Saccharomyces cerevisiae / cytology; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism
Source: Web Of Science
Added: October 29, 2018
2018 journal article
Kinetic Study of Degrafting Poly(methyl methacrylate) Brushes from Flat Substrates by Tetrabutylammonium Fluoride
MACROMOLECULES, 51(24), 10237–10245.
Sources: Web Of Science, ORCID
Added: January 14, 2019
2017 journal article
A defined and serum-free culture system for trophoblast differentiation of human embryonic stem cells
Placenta, 57, 237–238.
Source: Crossref
Added: February 24, 2020
2017 journal article
Design and Fabrication of Wettability Gradients with Tunable Profiles through Degrafting Organosilane Layers from Silica Surfaces by Tetrabutylammonium Fluoride
LANGMUIR, 33(51), 14556–14564.
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
IFPA meeting 2016 workshop report I: Genomic communication, bioinformatics, trophoblast biology and transport systems
Placenta, 60, S5–S9.
author keywords: Transport; Trophoblast; Bioinformatics; Exosomes; OMICS; DNA methylation
MeSH headings : Animals; Biological Transport; Biomedical Research / methods; Biomedical Research / trends; Computational Biology / methods; Computational Biology / trends; Congresses as Topic; DNA Methylation; Exome; Female; Genomics / methods; Genomics / trends; Humans; International Agencies; Maternal-Fetal Exchange; Placenta / cytology; Placenta / pathology; Placenta / physiology; Placenta / physiopathology; Pregnancy; Pregnancy Complications / pathology; Pregnancy Complications / physiopathology; Societies, Scientific; Trophoblasts / cytology; Trophoblasts / pathology; Trophoblasts / physiology
Sources: Crossref, NC State University Libraries
Added: August 6, 2018
2017 journal article
Identification and characterization of a novel Sso7d scaffold-based binder against Notch1
SCIENTIFIC REPORTS, 7.
MeSH headings : Animals; Archaeal Proteins / genetics; Archaeal Proteins / metabolism; Binding, Competitive / drug effects; Carrier Proteins / genetics; Carrier Proteins / metabolism; Carrier Proteins / pharmacology; Cell Line, Tumor; Cell Membrane / drug effects; Cell Membrane / metabolism; Colorectal Neoplasms / metabolism; Colorectal Neoplasms / pathology; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; HCT116 Cells; HEK293 Cells; Humans; MCF-7 Cells; Protein Binding; RNA Interference; Receptor, Notch1 / antagonists & inhibitors; Receptor, Notch1 / genetics; Receptor, Notch1 / metabolism; Spheroids, Cellular / drug effects; Spheroids, Cellular / metabolism
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Inefficient Ribosomal Skipping Enables Simultaneous Secretion and Display of Proteins in Saccharomyces cerevisiae
ACS SYNTHETIC BIOLOGY, 6(11), 2096–2107.
author keywords: yeast surface display; secretion; ribosomal skipping; 2A peptide; Sso7d; glucose oxidase
MeSH headings : Cell Adhesion Molecules / genetics; Cell Adhesion Molecules / metabolism; Gene Expression; Peptide Library; Peptides / genetics; Peptides / metabolism; Recombinant Proteins / biosynthesis; Recombinant Proteins / genetics; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism
Source: Web Of Science
Added: August 6, 2018
2016 journal article
BMP signaling plays a biphasic role during trophoblast differentiation of human embryonic stem cells
Placenta, 45, 99–100.
Source: Crossref
Added: February 24, 2020
2016 journal article
Combinatorial Pairwise Assembly Efficiently Generates High Affinity Binders and Enables a "Mix-and-Read" Detection Scheme
ACS SYNTHETIC BIOLOGY, 5(12), 1348–1354.
author keywords: Sso7d; binding affinity; yeast surface display; flexible linker; split GFP
MeSH headings : Archaeal Proteins / genetics; Archaeal Proteins / metabolism; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Escherichia coli / genetics; Escherichia coli / metabolism; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Mutagenesis; Peptide Library; Plasmids / genetics; Protein Conformation; Protein Engineering; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Yeasts / genetics; Yeasts / metabolism
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Identification of Epigenetic Factor Proteins Expressed in Human Embryonic Stem Cell-Derived Trophoblasts and in Human Placental Trophoblasts
JOURNAL OF PROTEOME RESEARCH, 15(8), 2433–2444.
author keywords: quantitative mass spectrometry; SILAC; human embryonic stem cell; trophoblast; epigenetic factor
MeSH headings : Cell Differentiation; DNA (Cytosine-5-)-Methyltransferases / genetics; Epigenomics; Female; Gene Expression / genetics; Human Embryonic Stem Cells / cytology; Humans; Placenta / chemistry; Placenta / cytology; Pregnancy; Transcription Factors / genetics; Trophoblasts / chemistry; Trophoblasts / cytology
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Targeted Mutagenesis and Combinatorial Library Screening Enables Control of Protein Orientation on Surfaces and Increased Activity of Adsorbed Proteins
LANGMUIR, 32(34), 8660–8667.
Sources: Web Of Science, ORCID
Added: August 6, 2018
2015 journal article
Activin/Nodal Signaling Switches the Terminal Fate of Human Embryonic Stem Cell-derived Trophoblasts
JOURNAL OF BIOLOGICAL CHEMISTRY, 290(14), 8834–8848.
MeSH headings : Activins / metabolism; Base Sequence; Cell Differentiation; Cell Lineage; DNA Methylation; DNA Primers; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Ephrin-B2 / genetics; Humans; Nodal Protein / metabolism; Polymerase Chain Reaction; Promoter Regions, Genetic; Signal Transduction; Trophoblasts / cytology; Trophoblasts / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
Avidity-mediated virus separation using a hyperthermophilic affinity ligand
BIOTECHNOLOGY PROGRESS, 29(1), 237–246.
author keywords: avidity; affinity ligand; hyperthermophilic; multivalent
MeSH headings : Archaeal Proteins / chemistry; Archaeal Proteins / isolation & purification; Archaeal Proteins / metabolism; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / isolation & purification; DNA-Binding Proteins / metabolism; Ligands; Molecular Weight; Plant Extracts; Plant Leaves / virology; Sulfolobus solfataricus / chemistry; Sulfolobus solfataricus / metabolism; Tobacco / virology; Tombusviridae / isolation & purification
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Generation and Properties of Antibacterial Coatings Based on Electrostatic Attachment of Silver Nanoparticles to Protein-Coated Polypropylene Fibers
ACS APPLIED MATERIALS & INTERFACES, 5(11), 5298–5306.
author keywords: antibacterial; polypropylene; protein adsorption; nanoparticle; functional coating
MeSH headings : Anti-Bacterial Agents / chemistry; Coated Materials, Biocompatible / chemistry; Escherichia coli / drug effects; Escherichia coli Infections / prevention & control; Hydrophobic and Hydrophilic Interactions; Light; Metal Nanoparticles / chemistry; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Polypropylenes / chemistry; Proteins / chemistry; Silver / chemistry; Static Electricity; Ultraviolet Rays
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
Preservation of Cell Viability and Protein Conformation on Immobilization within Nanofibers via Electrospinning Functionalized Yeast
ACS APPLIED MATERIALS & INTERFACES, 5(19), 9349–9354.
author keywords: electrospinning; nanofiber; protein; biocatalyst immobilization; yeast surface display
MeSH headings : Biocatalysis; Cell Survival / drug effects; Green Fluorescent Proteins; Microscopy, Electron, Scanning; Nanofibers / chemistry; Polymers / chemistry; Polymers / pharmacology; Polyvinyl Alcohol / chemistry; Polyvinyl Alcohol / pharmacology; Protein Conformation / drug effects; Saccharomyces cerevisiae / chemistry; Saccharomyces cerevisiae / drug effects; Saccharomyces cerevisiae / growth & development; Water / chemistry
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 review
Protein selection using yeast surface display
[Review of ]. METHODS, 60(1), 15–26.
author keywords: Yeast surface display; Protein engineering; Library screening; Biophysical characterization; Alternative scaffolds
MeSH headings : Combinatorial Chemistry Techniques; Flow Cytometry; Protein Engineering / methods; Yeasts / genetics; Yeasts / metabolism
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Scaffold Diversification Enhances Effectiveness of a Super library of Hyperthermophilic Proteins
ACS SYNTHETIC BIOLOGY, 2(1), 6–13.
author keywords: hyperthermophilic protein scaffolds; yeast surface display; protein engineering; alternate scaffold; mRNA display
MeSH headings : Biotechnology / methods; Carrier Proteins / genetics; Carrier Proteins / metabolism; Fungal Proteins / chemistry; Fungal Proteins / genetics; Fungal Proteins / metabolism; Models, Molecular; Peptide Library; Protein Conformation; Yeasts / genetics; Yeasts / metabolism
Source: Web Of Science
Added: August 6, 2018
2013 review
Trophoblast differentiation of human embryonic stem cells
[Review of ]. BIOTECHNOLOGY JOURNAL, 8(4), 421-+.
author keywords: Bone morphogenetic protein; CDX2; ELF5; hESC; Trophoblast
MeSH headings : Animals; Bone Morphogenetic Proteins / pharmacology; Cell Culture Techniques; Cell Differentiation / drug effects; Cell Differentiation / physiology; Embryonic Stem Cells / cytology; Embryonic Stem Cells / drug effects; Humans; Trophoblasts / cytology; Trophoblasts / drug effects
Source: Web Of Science
Added: August 6, 2018
2013 journal article
mRNA display selection and solid-phase synthesis of Fc-binding cyclic peptide affinity ligands
Biotechnology and Bioengineering, 110(3), 857–870.
author keywords: cyclic peptide; mRNA display; Fc binding; affinity ligand; library
MeSH headings : Humans; Immunoglobulin Fc Fragments / metabolism; Peptide Library; Peptides, Cyclic / chemistry; Peptides, Cyclic / genetics; Peptides, Cyclic / isolation & purification; Peptides, Cyclic / metabolism; Protein Binding; Protein Engineering / methods; RNA, Messenger / genetics; Solid-Phase Synthesis Techniques / methods
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Design of pH Sensitive Binding Proteins from the Hyperthermophilic Sso7d Scaffold
PLOS ONE, 7(11).
MeSH headings : Carrier Proteins / genetics; Carrier Proteins / metabolism; Epitopes / genetics; Escherichia coli / genetics; Escherichia coli / metabolism; Histidine / genetics; Histidine / metabolism; Humans; Hydrogen-Ion Concentration; Immunoglobulin Fc Fragments / genetics; Immunoglobulin Fc Fragments / metabolism; Immunoglobulin G / genetics; Immunoglobulin G / metabolism; Mutagenesis; Sulfolobus solfataricus / genetics; Sulfolobus solfataricus / metabolism
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Targeted Proteomics of the Secretory Pathway Reveals the Secretome of Mouse Embryonic Fibroblasts and Human Embryonic Stem Cells
MOLECULAR & CELLULAR PROTEOMICS, 11(12), 1829–1839.
MeSH headings : Animals; Cell Differentiation; Cells, Cultured; Culture Media, Conditioned / analysis; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Fibroblasts / cytology; Fibroblasts / metabolism; Humans; Mice; Proteins / analysis; Secretory Pathway; Subcellular Fractions / chemistry
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
The subcellular proteome of undifferentiated human embryonic stem cells
PROTEOMICS, 12(3), 421–430.
author keywords: Cell biology; Extracellular proteins; Human embryonic stem cells; Subcellular fractionation; Subcellular proteomics
MeSH headings : Animals; Cell Differentiation; Cells, Cultured; Culture Media, Conditioned; Cytosol / metabolism; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Endoplasmic Reticulum / genetics; Endoplasmic Reticulum / metabolism; Gene Expression Regulation, Developmental; Golgi Apparatus / genetics; Golgi Apparatus / metabolism; Humans; Membrane Proteins / genetics; Membrane Proteins / metabolism; Mice; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Signal Transduction / genetics; Subcellular Fractions / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018
2011 journal article
Comparison of stable-isotope labeling with amino acids in cell culture and spectral counting for relative quantification of protein expression
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 25(17), 2524–2532.
MeSH headings : Amino Acid Sequence; Amino Acids / chemistry; Amino Acids / metabolism; Animals; Cell Differentiation; Cell Line; Ectoderm; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Humans; Isotope Labeling / methods; Mass Spectrometry; Mice; Molecular Sequence Data; Peptide Fragments; Peptide Mapping; Proteins / analysis; Proteins / chemistry; Proteins / metabolism; Proteomics / methods; Sensitivity and Specificity; Tandem Mass Spectrometry; Time Factors
Sources: Web Of Science, ORCID
Added: August 6, 2018
2011 journal article
Highly Stable Binding Proteins Derived from the Hyperthermophilic Sso7d Scaffold
JOURNAL OF MOLECULAR BIOLOGY, 409(4), 601–616.
author keywords: hyperthermophilic protein scaffolds; yeast surface display; protein engineering; stability; alternate scaffold
MeSH headings : Amino Acid Sequence; Animals; Archaeal Proteins / chemistry; Archaeal Proteins / genetics; Archaeal Proteins / metabolism; Chickens; DNA Mutational Analysis; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Fluorescein / chemistry; Fluorescein / metabolism; Immunoglobulins / chemistry; Immunoglobulins / metabolism; Mice; Molecular Sequence Data; Muramidase / chemistry; Muramidase / metabolism; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Protein Denaturation; Streptavidin / chemistry; Streptavidin / metabolism; Sulfolobus solfataricus / chemistry; beta Catenin / chemistry; beta Catenin / metabolism
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Role of Signaling Pathways and Epigenetic Factors in Lineage Determination During Human Embryonic Stem Cell Differentiation
Embryonic Stem Cells - Differentiation and Pluripotent Alternatives, 1, 1.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Direct Comparison of Stable Isotope Labeling by Amino Acids in Cell Culture and Spectral Counting for Quantitative Proteomics
ANALYTICAL CHEMISTRY, 82(20), 8696–8702.
MeSH headings : Amino Acids / analysis; Animals; Cell Line; Humans; Isotope Labeling / methods; Mice; Proteomics / methods
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
Quantitative top-down proteomics of SILAC labeled human embryonic stem cells
Journal of the American Society for Mass Spectrometry, 21(6), 879–889.
MeSH headings : Amino Acid Sequence; Animals; Arginine / chemistry; Arginine / metabolism; Carbon Isotopes; Cell Line; Embryonic Stem Cells / chemistry; Embryonic Stem Cells / metabolism; Humans; Isotope Labeling / methods; Lysine / chemistry; Lysine / metabolism; Mass Spectrometry / methods; Mice; Proteome / analysis; Proteomics / methods
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2009 journal article
Molecular aspects of cardiac differentiation in embryonic stem cells
Critical Reviews in Biomedical Engineering, 37(4-5), 283–320.
MeSH headings : Animals; Cell Differentiation / physiology; Cells, Cultured; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Humans; Models, Biological; Myocytes, Cardiac / cytology; Myocytes, Cardiac / physiology; Signal Transduction / physiology; Transcription Factors / metabolism
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
NATURE CELL BIOLOGY, 10(7), 837–848.
MeSH headings : Active Transport, Cell Nucleus / physiology; Acyltransferases; Animals; Cell Line; Cell Nucleus / metabolism; Embryonic Stem Cells / cytology; Embryonic Stem Cells / physiology; Genes, Reporter; Humans; Mediator Complex; RNA, Small Interfering / genetics; RNA, Small Interfering / metabolism; Signal Transduction / physiology; Smad2 Protein / genetics; Smad2 Protein / metabolism; Smad3 Protein / genetics; Smad3 Protein / metabolism; Smad4 Protein / genetics; Smad4 Protein / metabolism; Transcription Factors / genetics; Transcription Factors / metabolism; Transcription, Genetic; Transforming Growth Factor beta / metabolism
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Niche-mediated control of human embryonic stem cell self-renewal and differentiation
EMBO JOURNAL, 26(22), 4744–4755.
author keywords: embryonic stem cell; micropatterning; niche; self-renewal; Smad signaling
MeSH headings : Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins / metabolism; Cell Differentiation; Cell Line; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Endoderm / metabolism; Fibroblast Growth Factors / antagonists & inhibitors; Growth Differentiation Factor 3; Humans; Smad1 Protein / metabolism; Transforming Growth Factor beta / antagonists & inhibitors; Transforming Growth Factor beta / metabolism
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Improved mutants from directed evolution are biased to orthologous substitutions
PROTEIN ENGINEERING DESIGN & SELECTION, 19(6), 245–253.
author keywords: epidermal growth factor; epidermal growth factor receptor; in vitro evolution; protein engineering; yeast display
MeSH headings : Base Sequence; Biosensing Techniques; Directed Molecular Evolution; Epidermal Growth Factor / chemistry; Epidermal Growth Factor / genetics; Epidermal Growth Factor / metabolism; ErbB Receptors / genetics; ErbB Receptors / metabolism; Fibroblasts / metabolism; Gene Library; Humans; Interleukin-2 / genetics; Interleukin-2 / metabolism; Mutagenesis; Mutation; Phylogeny; Protein Binding; Subtilisins / genetics; Subtilisins / metabolism; Transfection / methods; Yeasts / genetics
Source: Web Of Science
Added: August 6, 2018
2005 review
Culture development for human embryonic stem cell propagation: molecular aspects and challenges
[Review of ]. CURRENT OPINION IN BIOTECHNOLOGY, 16(5), 568–576.
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Engineering protein therapeutics within a systems-level computational context
Nature Biotechnology, 23(2), 191–194.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
High-Affinity CD25-Binding IL-2 Mutants Potently Stimulate Persistent T Cell Growth†
Biochemistry, 44(31), 10696–10701.
MeSH headings : Amino Acid Substitution / genetics; Cell Line; Cell Membrane / genetics; Cell Membrane / immunology; Cell Membrane / metabolism; Cell Proliferation; Directed Molecular Evolution; Humans; Interleukin-15 / metabolism; Interleukin-15 / physiology; Interleukin-2 / genetics; Interleukin-2 / metabolism; Interleukin-2 / physiology; Interleukin-2 Receptor alpha Subunit; Lymphocyte Activation / genetics; Mitogens / genetics; Mitogens / metabolism; Mitogens / physiology; Protein Binding / genetics; Receptors, Interleukin / metabolism; Receptors, Interleukin-15; Receptors, Interleukin-2 / metabolism; T-Lymphocytes / cytology; T-Lymphocytes / immunology
Source: Crossref
Added: August 28, 2020
2005 journal article
Integrating cell-level kinetic modeling into the design of engineered protein therapeutics
NATURE BIOTECHNOLOGY, 23(2), 191–194.
MeSH headings : Cell Physiological Phenomena; Computer Simulation; Drug Delivery Systems / methods; Drug Design; Drug Therapy, Computer-Assisted / methods; Gene Expression Regulation / drug effects; Gene Expression Regulation / physiology; Kinetics; Models, Biological; Protein Engineering / methods
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Interleukin 2 (IL-2) variants engineered for increased IL-2 receptor alpha-subunit affinity exhibit increased potency arising from a cell surface ligand reservoir effect
Molecular Pharmacology, 66(4), 864–869.
Source: NC State University Libraries
Added: August 6, 2018
2003 journal article
Interleukin-2 mutants with enhanced alpha-receptor subunit binding affinity
PROTEIN ENGINEERING, 16(12), 1081–1087.
author keywords: alpha-receptor subunit binding affinity; interleukin-2 mutants; T-cell stimulation
MeSH headings : Cell Division / genetics; Cell Division / physiology; Cloning, Molecular; Interleukin-2 / genetics; Interleukin-2 / metabolism; Interleukin-2 Receptor alpha Subunit; Mutation; Protein Binding / genetics; Protein Binding / physiology; Receptors, Interleukin / metabolism; Saccharomyces cerevisiae
Source: Web Of Science
Added: August 6, 2018
