Brittany P Rickard

Works (12)

Updated: January 18th, 2025 14:01

2024 article

Overcoming the effects of fluid shear stress in ovarian cancer cell lines: Doxorubicin alone or photodynamic priming to target platinum resistance

Overchuk, M., Rickard, B. P., Tulino, J., Tan, X., Ligler, F. S., Huang, H.-C., & Rizvi, I. (2024, June 7). PHOTOCHEMISTRY AND PHOTOBIOLOGY, Vol. 6.

By: M. Overchuk  n, B. Rickard* , J. Tulino n, X. Tan *, F. Ligler*, H. Huang *, I. Rizvi n 

author keywords: benzoporphyrin derivative; cisplatin; doxorubicin; high-grade serous ovarian carcinoma; ovarian cancer; photodynamic priming
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1. No Poverty (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 17, 2024

2024 article

PpIX-enabled fluorescence-based detection and photodynamic priming of platinum-resistant ovarian cancer cells under fluid shear stress

Ruhi, M. K., Rickard, B. P., Overchuk, M., Sinawang, P. D., Stanley, E., Mansi, M., … Rizvi, I. (2024, August 27). PHOTOCHEMISTRY AND PHOTOBIOLOGY, Vol. 8.

By: M. Ruhi  n, B. Rickard n , M. Overchuk  n, P. Sinawang *, E. Stanley  n, M. Mansi*, R. Sierra *, B. Hayes* ...

author keywords: fluid shear stress; ovarian cancer; photodynamic priming; platinum resistance; protoporphyrin IX
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3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 9, 2024

2023 journal article

Exposure to select PFAS and PFAS mixtures alters response to platinum-based chemotherapy in endometrial cancer cell lines

Environmental Health, 22(1).

By: B. Rickard* , M. Overchuk  n, J. Tulino n, X. Tan, F. Ligler*, V. Bae-Jump *, S. Fenton *, I. Rizvi n 

author keywords: PFAS; Endometrial cancer; Therapy resistance; Carboplatin; Cisplatin; Mitochondria
TL;DR: Investigation of the effect of environmental exposures, specifically PFAS, on platinum-based chemotherapy response and mitochondrial function in endometrial cancer suggests that PFAS exposure may affect endometrial cancer cell mitochondrial functioning. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: January 2, 2024

2023 journal article

Methods to Evaluate Changes in Mitochondrial Structure and Function in Cancer

Cancers, 15(9), 2564.

By: B. Rickard* , M. Overchuk  n, V. Chappell *, M. Kemal Ruhi *, P. Sinawang *, T. Nguyen Hoang *, D. Akin *, U. Demirci ...

author keywords: mitochondrial methods; bioenergetics; mitochondrial dysfunction; reactive species; mitochondrial function; mitochondrial structure; extracellular vesicles
TL;DR: Methods to evaluate the structural and functional parameters of mitochondrial health in the context of tumors and cancer cells are discussed, with a particular emphasis on gynecologic malignancies. (via Semantic Scholar)
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7. Affordable and Clean Energy (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: May 30, 2023

2022 journal article

A High-Throughput Toxicity Screen of 42 Per- and Polyfluoroalkyl Substances (PFAS) and Functional Assessment of Migration and Gene Expression in Human Placental Trophoblast Cells

Frontiers in Toxicology, 4.

By: B. Blake *, B. Rickard*  & S. Fenton *

Sources: ORCID, Crossref, NC State University Libraries
Added: September 4, 2024

2022 chapter

Integrins in Ovarian Cancer: Survival Pathways, Malignant Ascites and Targeted Photochemistry

In Recent Advances, New Perspectives and Applications in the Treatment of Ovarian Cancer.

By: M. Ruhi  n, B. Rickard n , W. Polacheck  n & I. Rizvi  n

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3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: November 19, 2024

2022 journal article

Photochemical Targeting of Mitochondria to Overcome Chemoresistance in Ovarian Cancer<sup>†

Photochemistry and Photobiology, 99(2), 448–468.

By: B. Rickard* , M. Overchuk  n, G. Obaid *, M. Ruhi *, U. Demirci *, S. Fenton *, J. Santos *, D. Kessel *, I. Rizvi n 

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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: October 31, 2022

2022 journal article

Photodynamic Priming Overcomes Per‐ and Polyfluoroalkyl Substance (<scp>PFAS

Photochemistry and Photobiology, 99(2), 793–813.

By: B. Rickard* , X. Tan *, S. Fenton * & I. Rizvi n 

Sources: ORCID, Crossref, NC State University Libraries
Added: July 15, 2024

2022 journal article

Select Per- and Polyfluoroalkyl Substances (PFAS) Induce Resistance to Carboplatin in Ovarian Cancer Cell Lines

International Journal of Molecular Sciences, 23(9), 5176.

By: B. Rickard* , X. Tan *, S. Fenton * & I. Rizvi n 

author keywords: per- and polyfluoroalkyl substances; PFAS; ovarian cancer; platinum resistance; carboplatin; mitochondrial function
MeSH headings : Alkanesulfonic Acids / toxicity; Carboplatin / pharmacology; Carcinoma, Ovarian Epithelial; Cell Line; Environmental Pollutants / toxicity; Female; Fluorocarbons / toxicity; Humans; Ovarian Neoplasms / drug therapy
TL;DR: This is the first study to demonstrate that, at sub-cytotoxic concentrations, select PFAS and PFAS mixtures increased survival fraction in ovarian cancer cells following carboplatin treatment, indicative of platinum resistance. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: May 23, 2022

2021 journal article

E-Cigarette Flavoring Chemicals Induce Cytotoxicity in HepG2 Cells

ACS Omega, 6(10), 6708–6713.

By: B. Rickard* , H. Ho *, J. Tiley *, I. Jaspers * & K. Brouwer *

UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: November 19, 2024

2021 review

Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and Biophysical Determinants of Molecular Characteristics and Therapy Response

[Review of ]. CANCERS, 13(17).

By: B. Rickard n , C. Conrad *, A. Sorrin*, M. Ruhi  n, J. Reader *, S. Huang n, W. Franco *, G. Scarcelli * ...

author keywords: malignant ascites; epithelial ovarian cancer; chemoresistance; mechanical stress; flow-induced shear stress; photodynamic therapy; tumor microenvironment; transcoelomic metastases; tumor heterogeneity; epithelial to mesenchymal transition
TL;DR: The current understanding of malignant ascites is summarized, starting with an overview of ovarian cancer and ascites, followed by a description of the tools used to analyze the components of ascites and how these components modulate ovarian cancer biology. (via Semantic Scholar)
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5. Gender Equality (Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 20, 2021

2021 journal article

Per- and poly-fluoroalkyl substances (PFAS) and female reproductive outcomes: PFAS elimination, endocrine-mediated effects, and disease

Toxicology, 465, 153031.

By: B. Rickard n , I. Rizvi n  & S. Fenton *

author keywords: PFAS; Female reproduction; Environmental contaminants; Endocrine disruption
MeSH headings : Endocrine Disruptors / adverse effects; Endocrine System Diseases / chemically induced; Endocrine System Diseases / metabolism; Endocrine System Diseases / physiopathology; Environmental Exposure / adverse effects; Environmental Pollutants / adverse effects; Female; Fertility / drug effects; Humans; Hydrocarbons, Fluorinated / adverse effects; Infertility, Female / chemically induced; Infertility, Female / metabolism; Infertility, Female / physiopathology; Menstrual Cycle / drug effects; Pregnancy; Pregnancy Complications / chemically induced; Pregnancy Complications / metabolism; Pregnancy Complications / physiopathology; Prognosis; Reproduction / drug effects; Risk Assessment; Risk Factors
TL;DR: The role of a variety of PFAS and PFAS mixtures in female reproductive tract dysfunction and disease is summarized and the role ofPFAS in breast, thyroid, and hypothalamic-pituitary-gonadal axis function is discussed as the interplay between these tissues may be critical in understanding the long-term reproductive health effects of PFas in women. (via Semantic Scholar)
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Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: November 29, 2021

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