Brittany P Rickard

Works (19)

Updated: February 24th, 2026 19:55

2026 article

Recovery from chronic PFAS exposure can reverse chemotherapy resistance and mitochondrial alterations in ovarian cancer cells

Rickard, B. P., Sapienza-Lundie, L. A., Chappell, V. A., Fenton, S. E., & Rizvi, I. (2026, February 19). Toxicology Letters.

By: B. Rickard n , L. Sapienza-Lundie*, V. Chappell *, S. Fenton n & I. Rizvi*

topics (OpenAlex): Per- and polyfluoroalkyl substances research; Sulfur Compounds in Biology; Cancer, Hypoxia, and Metabolism; Toxic Organic Pollutants Impact; Fluoride Effects and Removal
Source: ORCID
Added: February 19, 2026

2025 article

Chronic PFAS exposure induces chemotherapy resistance by promoting mitochondria-related alterations in ovarian cancer cells

Rickard, B. P., Sapienza-Lundie, L. A., Overchuk, M., Tulino, J., Mori, M. P., McCord, J. P., … Rizvi, I. (2025, June 21). Environmental Research, Vol. 284.

By: B. Rickard n , L. Sapienza-Lundie*, M. Overchuk  n, J. Tulino n, M. Mori *, J. McCord*, V. Chappell *, C. Bortner * ...

author keywords: Perfluoroalkyl substances; PFAS; Ovarian cancer; Chemoresistance; Platinum resistance; Mitochondria
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Toxic Organic Pollutants Impact; Effects and risks of endocrine disrupting chemicals
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 1, 2025

2025 article

Mitochondrial membrane hyperpolarization modulates nuclear DNA methylation and gene expression through phospholipid remodeling

Mori, M. P., Lozoya, O. A., Brooks, A. M., Bortner, C. D., Nadalutti, C. A., Ryback, B., … Santos, J. H. (2025, April 29). Nature Communications, Vol. 16.

By: M. Mori *, O. Lozoya *, A. Brooks *, C. Bortner *, C. Nadalutti *, B. Ryback *, B. Rickard* , M. Overchuk  n ...

MeSH headings : Phospholipids / metabolism; DNA Methylation; Membrane Potential, Mitochondrial / genetics; Humans; Mitochondrial Membranes / metabolism; Mitochondria / metabolism; Mitochondria / genetics; Animals; Cell Nucleus / metabolism; Cell Nucleus / genetics; Mice; Cell Line, Tumor; Female; Mitochondrial Proton-Translocating ATPases / genetics; Mitochondrial Proton-Translocating ATPases / metabolism
topics (OpenAlex): Mitochondrial Function and Pathology; Metabolism and Genetic Disorders; ATP Synthase and ATPases Research
Sources: ORCID, Web Of Science, NC State University Libraries
Added: April 29, 2025

2025 article

Photodynamic priming ( PDP ) targets platinum resistance from chronic perfluoroalkyl substances ( PFAS ) exposure in ovarian cancer cells

Rickard, B. P., Dillon, M. M., Sapienza‐Lundie, L. A., Fenton, S. E., & Rizvi, I. (2025, November 6). Photochemistry and Photobiology.

By: B. Rickard n , M. Dillon  n, L. Sapienza‐Lundie n, S. Fenton  n & I. Rizvi n 

topics (OpenAlex): Per- and polyfluoroalkyl substances research; Carbon and Quantum Dots Applications; Fluorine in Organic Chemistry
Source: ORCID
Added: November 6, 2025

2025 article

Photodynamic priming overcomes platinum resistance from short‐term exposure to select perfluoroalkyl substances in endometrial cancer cell lines

Rickard, B. P., Sapienza‐Lundie, L. A., Overchuk, M., Tan, X., Bae‐Jump, V. L., Yates, M. S., … Rizvi, I. (2025, March 10). Photochemistry and Photobiology, Vol. 101, pp. 1177–1198.

By: B. Rickard n , L. Sapienza‐Lundie n, M. Overchuk  n, X. Tan *, V. Bae‐Jump *, M. Yates *, S. Fenton n , I. Rizvi n 

author keywords: endometrial cancer; PDT; PFAS; photodynamic priming; platinum resistance
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Photodynamic Therapy Research Studies; Nanoplatforms for cancer theranostics
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 11, 2025

2025 article

Photodynamic therapy simultaneously induces ferroptosis- and apoptosis-like lipid signatures in ovarian cancer cells

Overchuk, M., Choi, A. M., Rickard, B. P., Schnoor, B., Ehrmann, B. M., Girotti, A. W., … Rizvi, I. (2025, December 10). Cell Death and Disease.

By: M. Overchuk  n, A. Choi  n, B. Rickard n , B. Schnoor*, B. Ehrmann *, A. Girotti *, D. Zaharoff  n, H. Huang * ...

MeSH headings : Ferroptosis / drug effects; Female; Humans; Photochemotherapy / methods; Ovarian Neoplasms / pathology; Ovarian Neoplasms / drug therapy; Ovarian Neoplasms / metabolism; Apoptosis / drug effects; Cell Line, Tumor; Animals; Lipid Peroxidation / drug effects; Mice; Photosensitizing Agents / pharmacology
topics (OpenAlex): Ferroptosis and cancer prognosis; Photodynamic Therapy Research Studies; Nanoplatforms for cancer theranostics
Sources: ORCID, NC State University Libraries
Added: December 13, 2025

2024 article

PpIX‐enabled fluorescence‐based detection and photodynamic priming of platinum‐resistant ovarian cancer cells under fluid shear stress

Ruhi, M. K., Rickard, B. P., Overchuk, M., Sinawang, P. D., Stanley, E., Mansi, M., … Rizvi, I. (2024, August 27). Photochemistry and Photobiology, Vol. 8.

By: M. Ruhi  n, B. Rickard n , M. Overchuk  n, P. Sinawang *, E. Stanley  n, M. Mansi*, R. Sierra *, B. Hayes* ...

author keywords: fluid shear stress; ovarian cancer; photodynamic priming; platinum resistance; protoporphyrin IX
MeSH headings : Humans; Female; Ovarian Neoplasms / drug therapy; Ovarian Neoplasms / pathology; Ovarian Neoplasms / metabolism; Drug Resistance, Neoplasm; Cell Line, Tumor; Protoporphyrins / metabolism; Photochemotherapy / methods; Aminolevulinic Acid / pharmacology; Aminolevulinic Acid / therapeutic use; Photosensitizing Agents / therapeutic use; Photosensitizing Agents / pharmacology; Carboplatin / pharmacology; Platinum / therapeutic use; Platinum / pharmacology; Fluorescence; Stress, Mechanical; Antineoplastic Agents / pharmacology
topics (OpenAlex): Nanoplatforms for cancer theranostics; Photodynamic Therapy Research Studies; Advanced Fluorescence Microscopy Techniques
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 9, 2024

2024 article

Overcoming the effects of fluid shear stress in ovarian cancer cell lines: Doxorubicin alone or photodynamic priming to target platinum resistance

Overchuk, M., Rickard, B. P., Tulino, J., Tan, X., Ligler, F. S., Huang, H. C., & Rizvi, I. (2024, June 7). Photochemistry and Photobiology, Vol. 6.

By: M. Overchuk  n, B. Rickard* , J. Tulino n, X. Tan *, F. Ligler*, H. Huang *, I. Rizvi n 

author keywords: benzoporphyrin derivative; cisplatin; doxorubicin; high-grade serous ovarian carcinoma; ovarian cancer; photodynamic priming
MeSH headings : Doxorubicin / pharmacology; Female; Humans; Ovarian Neoplasms / drug therapy; Ovarian Neoplasms / metabolism; Ovarian Neoplasms / pathology; Drug Resistance, Neoplasm; Cell Line, Tumor; Photochemotherapy; Cisplatin / pharmacology; Antineoplastic Agents / pharmacology; Stress, Mechanical; Mitochondria / drug effects; Mitochondria / metabolism; Photosensitizing Agents / pharmacology
topics (OpenAlex): Photodynamic Therapy Research Studies; Nanoplatforms for cancer theranostics; Nanoparticle-Based Drug Delivery
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 17, 2024

2024 article

Precision environmental health: Establishing the role of environmental exposures in personalized medicine for oncology

Hamilton, A. M., Rickard, B. P., & Fenton, S. E. (2024, December 25). Environment International, Vol. 195.

By: A. Hamilton n, B. Rickard n  & S. Fenton n 

topics (OpenAlex): Health, Environment, Cognitive Aging; Effects and risks of endocrine disrupting chemicals; Science, Research, and Medicine
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 24, 2025

2023 journal article

Exposure to select PFAS and PFAS mixtures alters response to platinum-based chemotherapy in endometrial cancer cell lines

Environmental Health, 22(1).

By: B. Rickard* , M. Overchuk  n, J. Tulino n, X. Tan, F. Ligler*, V. Bae-Jump *, S. Fenton* , I. Rizvi n 

author keywords: PFAS; Endometrial cancer; Therapy resistance; Carboplatin; Cisplatin; Mitochondria
MeSH headings : Female; Humans; Carboplatin / toxicity; Carboplatin / therapeutic use; Cisplatin / pharmacology; Cisplatin / therapeutic use; Platinum / therapeutic use; Endometrial Neoplasms / drug therapy; Endometrial Neoplasms / chemically induced; Cell Line; Fluorocarbons
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Cancer Risks and Factors; Vitamin D Research Studies
TL;DR: Investigation of the effect of environmental exposures, specifically PFAS, on platinum-based chemotherapy response and mitochondrial function in endometrial cancer suggests that PFAS exposure may affect endometrial cancer cell mitochondrial functioning. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: January 2, 2024

2023 journal article

Methods to Evaluate Changes in Mitochondrial Structure and Function in Cancer

Cancers, 15(9), 2564.

By: B. Rickard* , M. Overchuk  n, V. Chappell *, M. Kemal Ruhi *, P. Sinawang *, T. Nguyen Hoang *, D. Akin *, U. Demirci ...

author keywords: mitochondrial methods; bioenergetics; mitochondrial dysfunction; reactive species; mitochondrial function; mitochondrial structure; extracellular vesicles
topics (OpenAlex): Mitochondrial Function and Pathology; ATP Synthase and ATPases Research; RNA modifications and cancer
TL;DR: Methods to evaluate the structural and functional parameters of mitochondrial health in the context of tumors and cancer cells are discussed, with a particular emphasis on gynecologic malignancies. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: May 30, 2023

2022 journal article

A High-Throughput Toxicity Screen of 42 Per- and Polyfluoroalkyl Substances (PFAS) and Functional Assessment of Migration and Gene Expression in Human Placental Trophoblast Cells

Frontiers in Toxicology, 4.

By: B. Blake *, B. Rickard*  & S. Fenton* 

topics (OpenAlex): Per- and polyfluoroalkyl substances research; Gestational Diabetes Research and Management; Birth, Development, and Health
Sources: ORCID, Crossref, NC State University Libraries
Added: September 4, 2024

2022 article

Integrins in Ovarian Cancer: Survival Pathways, Malignant Ascites and Targeted Photochemistry

Ruhi, M. K., Rickard, B. P., Polacheck, W. J., & Rizvi, I. (2022, September 14). IntechOpen EBooks.

By: M. Ruhi  n, B. Rickard n , W. Polacheck  n & I. Rizvi  n

topics (OpenAlex): Cell Adhesion Molecules Research; Angiogenesis and VEGF in Cancer; Immunotherapy and Immune Responses
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: November 19, 2024

2022 journal article

Photochemical Targeting of Mitochondria to Overcome Chemoresistance in Ovarian Cancer†

Photochemistry and Photobiology, 99(2), 448–468.

By: B. Rickard* , M. Overchuk  n, G. Obaid *, M. Ruhi *, U. Demirci *, S. Fenton* , J. Santos *, D. Kessel *, I. Rizvi n 

MeSH headings : Female; Humans; Photochemotherapy; Drug Resistance, Neoplasm; Photosensitizing Agents / pharmacology; Photosensitizing Agents / therapeutic use; Photosensitizing Agents / metabolism; Ovarian Neoplasms / drug therapy; Mitochondria / metabolism; Cell Line, Tumor
topics (OpenAlex): Cancer, Hypoxia, and Metabolism; Nanoplatforms for cancer theranostics; Photodynamic Therapy Research Studies
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: October 31, 2022

2022 journal article

Photodynamic Priming Overcomes Per‐ and Polyfluoroalkyl Substance (PFAS

Photochemistry and Photobiology, 99(2), 793–813.

By: B. Rickard* , X. Tan *, S. Fenton*  & I. Rizvi n 

MeSH headings : Female; Humans; Ovarian Neoplasms / drug therapy; Carboplatin / pharmacology; Carboplatin / therapeutic use; Apoptosis; Cell Line, Tumor; Photosensitizing Agents / pharmacology; Photosensitizing Agents / therapeutic use; Fluorocarbons / pharmacology; Photochemotherapy
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Photodynamic Therapy Research Studies; Atmospheric Ozone and Climate
Sources: ORCID, Crossref, NC State University Libraries
Added: July 15, 2024

2022 journal article

Select Per- and Polyfluoroalkyl Substances (PFAS) Induce Resistance to Carboplatin in Ovarian Cancer Cell Lines

International Journal of Molecular Sciences, 23(9), 5176.

By: B. Rickard* , X. Tan *, S. Fenton*  & I. Rizvi n 

author keywords: per- and polyfluoroalkyl substances; PFAS; ovarian cancer; platinum resistance; carboplatin; mitochondrial function
MeSH headings : Alkanesulfonic Acids / toxicity; Carboplatin / pharmacology; Carcinoma, Ovarian Epithelial; Cell Line; Environmental Pollutants / toxicity; Female; Fluorocarbons / toxicity; Humans; Ovarian Neoplasms / drug therapy
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Atmospheric chemistry and aerosols; Atmospheric Ozone and Climate
TL;DR: This is the first study to demonstrate that, at sub-cytotoxic concentrations, select PFAS and PFAS mixtures increased survival fraction in ovarian cancer cells following carboplatin treatment, indicative of platinum resistance. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: May 23, 2022

2021 article

E-Cigarette Flavoring Chemicals Induce Cytotoxicity in HepG2 Cells

Rickard, B. P., Ho, H., Tiley, J. B., Jaspers, I., & Brouwer, K. L. R. (2021, March 2). ACS Omega, Vol. 6, pp. 6708–6713.

By: B. Rickard* , H. Ho *, J. Tiley *, I. Jaspers * & K. Brouwer *

topics (OpenAlex): Carcinogens and Genotoxicity Assessment; Alcohol Consumption and Health Effects; Smoking Behavior and Cessation
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: November 19, 2024

2021 article

Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and Biophysical Determinants of Molecular Characteristics and Therapy Response

Rickard, B. P., Conrad, C., Sorrin, A. J., Ruhi, M. K., Reader, J. C., Huang, S. A., … Rizvi, I. (2021, August 26). Cancers, Vol. 13, p. 4318.

By: B. Rickard n , C. Conrad *, A. Sorrin*, M. Ruhi  n, J. Reader *, S. Huang n, W. Franco *, G. Scarcelli * ...

author keywords: malignant ascites; epithelial ovarian cancer; chemoresistance; mechanical stress; flow-induced shear stress; photodynamic therapy; tumor microenvironment; transcoelomic metastases; tumor heterogeneity; epithelial to mesenchymal transition
topics (OpenAlex): Ovarian cancer diagnosis and treatment; Intraperitoneal and Appendiceal Malignancies; Endometriosis Research and Treatment
TL;DR: The current understanding of malignant ascites is summarized, starting with an overview of ovarian cancer and ascites, followed by a description of the tools used to analyze the components of ascites and how these components modulate ovarian cancer biology. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 20, 2021

2021 journal article

Per- and poly-fluoroalkyl substances (PFAS) and female reproductive outcomes: PFAS elimination, endocrine-mediated effects, and disease

Toxicology, 465, 153031.

By: B. Rickard n , I. Rizvi n  & S. Fenton* 

author keywords: PFAS; Female reproduction; Environmental contaminants; Endocrine disruption
MeSH headings : Endocrine Disruptors / adverse effects; Endocrine System Diseases / chemically induced; Endocrine System Diseases / metabolism; Endocrine System Diseases / physiopathology; Environmental Exposure / adverse effects; Environmental Pollutants / adverse effects; Female; Fertility / drug effects; Humans; Hydrocarbons, Fluorinated / adverse effects; Infertility, Female / chemically induced; Infertility, Female / metabolism; Infertility, Female / physiopathology; Menstrual Cycle / drug effects; Pregnancy; Pregnancy Complications / chemically induced; Pregnancy Complications / metabolism; Pregnancy Complications / physiopathology; Prognosis; Reproduction / drug effects; Risk Assessment; Risk Factors
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Toxic Organic Pollutants Impact; Effects and risks of endocrine disrupting chemicals
TL;DR: The role of a variety of PFAS and PFAS mixtures in female reproductive tract dysfunction and disease is summarized and the role ofPFAS in breast, thyroid, and hypothalamic-pituitary-gonadal axis function is discussed as the interplay between these tissues may be critical in understanding the long-term reproductive health effects of PFas in women. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: November 29, 2021

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