Works (38)

Updated: August 3rd, 2023 21:15

2022 article

A roadmap towards equitable hiring to diversify biomedical engineering faculty

Cosgriff-Hernandez, E., Aguado, B. A., Akpa, B. S., Fleming, G. C., Moore, E., Porras, A. M., … Bowden, A. (2022, June 16). (Vol. 6). Vol. 6.

By: E. Cosgriff-Hernandez, B. Aguado, B. Akpa*, G. Fleming, E. Moore, A. Porras, P. Boyle, D. Chan ...

Source: ORCID
Added: July 2, 2022

2022 journal article

Cholesterol-induced suppression of Kir2 channels is mediated by decoupling at the inter-subunit interfaces

ISCIENCE, 25(5).

By: N. Barbera*, S. Granados*, C. Vanoye*, T. Abramova*, D. Kulbak*, S. Ahn*, A. George*, B. Akpa n, I. Levitan*

TL;DR: It was found that increasing membrane cholesterol reduced the likelihood of contact between specific regions of the cytoplasmic and transmembrane domains of the channel, most prominently at the subunit-subunit interfaces of the cytosolic domains. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 9, 2022

2021 article

Predicting Inter-individual Variability During Lipid Resuscitation of Bupivacaine Cardiotoxicity in Rats: A Virtual Population Modeling Study

McDaniel, M., Flores, K. B., & Akpa, B. S. (2021, July 19). DRUGS IN R&D, Vol. 7.

By: M. McDaniel n, K. Flores n & B. Akpa*

MeSH headings : Anesthetics, Local / toxicity; Animals; Bupivacaine / toxicity; Cardiotoxicity; Lipids; Rats; Rats, Sprague-Dawley
TL;DR: A mechanistic model predicted a plausible range of treatment outcomes that accurately predicts changes in LD50 when extrapolated to putatively toxic doses of bupivacaine, and causal analysis of the predicted survival outcomes indicated a critical synergy between scavenging and direct cardiotonic mechanisms of ILE action. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 20, 2021

2021 review

Solving the puzzle of Fe homeostasis by integrating molecular, mathematical, and societal models

[Review of ]. CURRENT OPINION IN PLANT BIOLOGY, 64.

By: C. Hodgens n, B. Akpa* & T. Long n

author keywords: Iron homeostasis; Simulation-based inference (SBI); Inclusivity
MeSH headings : Biological Transport; Gene Expression Regulation, Plant; Homeostasis; Iron / metabolism; Plants / genetics; Plants / metabolism
TL;DR: This work examines recent advances in the understanding of cellular responses to Fe deficiency and uses intracellular mechanisms of Fe homeostasis to discuss how formalizing cell biology knowledge via a mathematical model can advance discovery even when quantitative data is limited. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 27, 2021

2020 chapter

Utility of stable isotope ratios of tap water and human hair in determining region of origin in Central and Southern Mexico

In Forensic Science and Humanitarian Action.

Belinda Akpa

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: April 7, 2020

2019 journal article

Molecular Dynamics Simulations of Kir2.2 and Cholesterol Reveal State- and Concentration-Dependent Binding Sites

Biophysical Journal, 116(3), 41a.

By: N. Barbera*, M. Ayee*, B. Akpa n & I. Levitan

UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: December 16, 2019

2019 journal article

Oxygen and hydrogen isotopes in human hair and tap water: Modeling relationships in a modern Mexican population

Human Biology, 90(3), 197–211.

By: C. Juarez, R. Ramey, D. Flaherty & B. Akpa*

Contributors: C. Juarez, R. Ramey, D. Flaherty & B. Akpa*

author keywords: delta H-2; delta O-18; MEXICO; TAP WATER; HAIR
TL;DR: Data from this Mexican population did not exhibit the strong relationships between isotope values of 18O and 2H in tap water and hair that have been characteristic of other populations studied to date, and the results with parameters based on the American supermarket diet were disappointing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
14. Life Below Water (Web of Science)
Source: ORCID
Added: April 7, 2020

2018 journal article

Molecular Dynamics Simulations of Kir2.2 Interactions with an Ensemble of Cholesterol Molecules

BIOPHYSICAL JOURNAL, 115(7), 1264–1280.

By: N. Barbera*, M. Ayee*, B. Akpa n & I. Levitan*

Contributors: N. Barbera*, M. Ayee*, B. Akpa n & I. Levitan*

MeSH headings : Binding Sites; Cholesterol / metabolism; Elasticity; Ion Channel Gating; Molecular Dynamics Simulation; Potassium Channels, Inwardly Rectifying / chemistry; Potassium Channels, Inwardly Rectifying / metabolism; Protein Binding; Protein Conformation
TL;DR: Martini coarse-grained simulations are used to analyze the long timescale dynamics of cholesterol with Kir2.2 channels and find that the cholesterol environment surrounding Kir channels forms a complex milieu of different short- and long-term interactions, with multiple cholesterol molecules concurrently interacting with the channel. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 16, 2018

2017 article

Differential Effects of Sterols on Ion Channels: Stereospecific Binding vs Stereospecific Response

STEROL REGULATION OF ION CHANNELS, Vol. 80, pp. 25–50.

By: N. Barbera*, M. Ayee*, B. Akpa n & I. Levitan*

Contributors: N. Barbera*, M. Ayee*, B. Akpa n & I. Levitan*

MeSH headings : Cell Membrane / metabolism; Humans; Ion Channels / chemistry; Ion Channels / metabolism; Protein Binding; Stereoisomerism; Sterols / chemistry; Sterols / metabolism; Sterols / pharmacology; Substrate Specificity
TL;DR: Accumulating evidence suggests that the structural requirements of ion channel cholesterol-binding sites are lax, allowing chiral isomers of cholesterol to bind to the same site in a nonstereospecific way, but the ability of a sterol to confer a functional effect on the channel activity can still be stereospespecific. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Molecular-Scale Biophysical Modulation of an Endothelial Membrane by Oxidized Phospholipids

BIOPHYSICAL JOURNAL, 112(2), 325–338.

By: M. Ayee*, E. LeMaster*, T. Shentu*, D. Singh*, N. Barbera*, D. Soni*, C. Tiruppathi*, P. Subbaiah* ...

Contributors: M. Ayee*, E. LeMaster*, T. Shentu*, D. Singh*, N. Barbera*, D. Soni*, C. Tiruppathi*, P. Subbaiah* ...

MeSH headings : Animals; Biomechanical Phenomena / drug effects; Cattle; Cell Membrane / chemistry; Cell Membrane / drug effects; Cell Membrane / metabolism; Endothelial Cells / cytology; Lipid Bilayers / chemistry; Lipid Bilayers / metabolism; Mechanical Phenomena / drug effects; Molecular Conformation; Molecular Dynamics Simulation; Phospholipid Ethers / chemistry; Phospholipid Ethers / pharmacology
TL;DR: The results suggest that disruptions in membrane structure by oxidized phospholipids play a role in the regulation of overall endothelial cell stiffness. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Using spectral and cumulative spectral entropy to classify anomalous diffusion in Sephadex (TM) gels

COMPUTERS & MATHEMATICS WITH APPLICATIONS, 73(5), 765–774.

By: Y. Liang, W. Chen, B. Akpa*, T. Neuberger, A. Webb & R. Magin

Contributors: Y. Liang, W. Chen, B. Akpa*, T. Neuberger, A. Webb & R. Magin

author keywords: Anomalous diffusion; Fractional derivative; Cumulative spectral entropy; Continuous time random walk; Magnetic resonance imaging; Sephadex (TM) gel
TL;DR: This study investigates the relationship between the ADC of water and the complexity of a series of Sephadexgel beads and finds that both measures of entropy increase with the porosity and tortuosity of the gel in a manner consistent with fractional order diffusional dynamics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

Endothelial Membrane Modulation by OxLDL: Molecular-Scale Effects of Oxidation Products on Model Membranes

Biophysical Journal, 110(3), 81a.

By: M. Ayee*, E. LeMaster*, B. Akpa n & I. Levitan*

TL;DR: A molecular-scale investigation of changes induced in endothelial membranes in the presence of various oxidation products using coarse-grained molecular dynamics simulations may begin to clarify some of the molecular mechanisms underlying endothelial cell dysfunction resulting from exposure to OxLDL. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 4, 2020

2016 journal article

Molecular Dynamics Simulations of Kir2.2-Cholesterol Interactions

Biophysical Journal, 110(3), 186a.

By: N. Barbera*, M. Ayee*, B. Akpa n & I. Levitan*

TL;DR: A computational approach which utilizes coarse-grained molecular dynamics simulations - employing the MARTINI force field - to further investigate the spatial and temporal mechanics of cholesterol binding has allowed for a greater range of binding effects, such as binding time, binding instances, changes in channel conformation, and ion flux through the channel. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 4, 2020

2016 journal article

Structural perturbation of a dipalmitoylphosphatidylcholine (DPPC) bilayer by warfarin and its bolaamphiphilic analogue: A molecular dynamics study

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 468, 227–237.

By: M. Ayee*, C. Roth* & B. Akpa n

Contributors: M. Ayee*, C. Roth* & B. Akpa n

author keywords: Bolaamphiphile; Bilayer; Anticoagulant; Toxicity; Permeation; Phospholipid; Warfarin; Brodifacoum; Defect; Hydroxycoumarin
MeSH headings : 1,2-Dipalmitoylphosphatidylcholine / chemistry; Lipid Bilayers / chemistry; Molecular Dynamics Simulation; Molecular Structure; Surface-Active Agents / chemistry; Warfarin / chemistry
TL;DR: The consequences of anticoagulant accumulation in a dipalmitoylphosphatidylcholine bilayer are explored and it is found that brodifacoum partitioning into bilayers causes membrane thinning and permeabilization and promotes lipid flip-flop - phenomena that are suspected to play a role in triggering cell death. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2016 article

The emerging threat of superwarfarins: history, detection, mechanisms, and countermeasures

COUNTERMEASURES AGAINST CHEMICAL THREATS, Vol. 1374, pp. 111–122.

By: D. Feinstein*, B. Akpa n, M. Ayee*, A. Boullerne*, D. Braun*, S. Brodsky*, D. Gidalevitz*, Z. Hauck* ...

Contributors: D. Feinstein*, B. Akpa n, M. Ayee*, A. Boullerne*, D. Braun*, S. Brodsky*, D. Gidalevitz*, Z. Hauck* ...

author keywords: superwarfarins; brodifacoum; HPLC; lipid membrane; neuropathology; nephrotoxicity; intralipid
MeSH headings : Animals; Anticoagulants / adverse effects; Anticoagulants / analysis; Anticoagulants / chemistry; Biomarkers / analysis; Environmental Exposure / analysis; Humans; Kidney / drug effects; Kidney / pathology; Nervous System / drug effects; Nervous System / pathology; Warfarin / adverse effects; Warfarin / analysis; Warfarin / chemistry; Warfarin / poisoning
TL;DR: This review summarizes superwarfarin development, biology and pathophysiology, their threat as weapons, and possible therapeutic approaches, including both vitamin K–dependent and –independent effects, which are not mitigated by vitamin K therapy. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Confusion About Infusion: Rational Volume Limits for Intravenous Lipid Emulsion During Treatment of Oral Overdoses.

Annals of Emergency Medicine, 66(2), 185–188.

By: M. Fettiplace*, B. Akpa*, I. Rubinstein* & G. Weinberg*

Contributors: M. Fettiplace*, B. Akpa*, I. Rubinstein* & G. Weinberg*

MeSH headings : Bupropion / poisoning; Drug Overdose / therapy; Fat Emulsions, Intravenous / administration & dosage; Fat Emulsions, Intravenous / therapeutic use; Humans; Lamotrigine; Triazines / poisoning
TL;DR: There is a need for rational volume limits to prevent undisciplined use of intravenous lipid emulsion in lipid resuscitation therapy, as several case reports have identified the potential usefulness of prolonged lipid infusions for enteral toxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: May 18, 2019

2015 journal article

Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride micro-emulsion

Journal of Controlled Release, 198, 62–70.

By: M. Fettiplace*, K. Lis*, R. Ripper*, K. Kowal*, A. Pichurko*, D. Vitello*, I. Rubinstein*, D. Schwartz*, B. Akpa*, G. Weinberg*

Contributors: M. Fettiplace*, K. Lis*, R. Ripper*, K. Kowal*, A. Pichurko*, D. Vitello*, I. Rubinstein*, D. Schwartz*, B. Akpa*, G. Weinberg*

author keywords: Lipid emulsion; Local anesthetic; Bupivacaine; Triglyceride; Antidote; Biodetoxification
MeSH headings : Animals; Bupivacaine / pharmacokinetics; Bupivacaine / toxicity; Cardiac Output / drug effects; Cardiotonic Agents / administration & dosage; Cardiotonic Agents / pharmacology; Cardiotonic Agents / therapeutic use; Cardiotoxicity / drug therapy; Cardiotoxicity / metabolism; Cardiotoxicity / physiopathology; Cardiotoxins / pharmacokinetics; Cardiotoxins / toxicity; Emulsions / administration & dosage; Emulsions / pharmacology; Emulsions / therapeutic use; Liver / metabolism; Models, Biological; Muscle, Skeletal / metabolism; Myocardium / metabolism; Phospholipids / administration & dosage; Phospholipids / pharmacology; Phospholipids / therapeutic use; Rats; Soybean Oil / administration & dosage; Soybean Oil / pharmacology; Soybean Oil / therapeutic use; Triglycerides / administration & dosage; Triglycerides / pharmacology; Triglycerides / therapeutic use
TL;DR: An integrated mechanism of reversal of bupivacaine toxicity that includes both transient drug scavenging and a cardiotonic effect that couple to accelerate movement of the toxin away from sites of toxicity is reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: May 18, 2019

2014 journal article

Resuscitation with lipid emulsion: dose-dependent recovery from cardiac pharmacotoxicity requires a cardiotonic effect.

Anesthesiology, 120(4), 915–925.

By: M. Fettiplace*, B. Akpa*, R. Ripper*, B. Zider*, J. Lang*, I. Rubinstein*, G. Weinberg*

Contributors: M. Fettiplace*, B. Akpa*, R. Ripper*, B. Zider*, J. Lang*, I. Rubinstein*, G. Weinberg*

MeSH headings : Anesthetics, Local / toxicity; Animals; Bupivacaine / toxicity; Cardiotonic Agents / therapeutic use; Disease Models, Animal; Dose-Response Relationship, Drug; Fat Emulsions, Intravenous / therapeutic use; Heart / drug effects; Heart / physiopathology; Heart Arrest / chemically induced; Heart Arrest / therapy; Heart Rate / drug effects; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Resuscitation / methods; Sodium Chloride / administration & dosage; Time Factors; Treatment Outcome
TL;DR: Intravenous lipid emulsion accelerates cardiovascular recovery from bupivacaine toxicity in a dose-dependent manner, which is driven by a cardiotonic response that complements the previously reported sequestration effect. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: May 18, 2019

2013 conference paper

Positive inotropy - A likely mechanism for lipid reversal of local anesthetic toxicity

Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future, 535. http://www.scopus.com/inward/record.url?eid=2-s2.0-84911417408&partnerID=MN8TOARS

By: B. Akpa

Contributors: B. Akpa

Source: ORCID
Added: April 7, 2020

2013 conference paper

Sequestering of toxins for the reversal of drug toxicity: A coarse grained molecular dynamics study

Computational Molecular Science and Engineering Forum 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future, 248. http://www.scopus.com/inward/record.url?eid=2-s2.0-84911478625&partnerID=MN8TOARS

By: M. Ayee & B. Akpa

Contributors: M. Ayee & B. Akpa

Source: ORCID
Added: April 7, 2020

2013 journal article

Validity of the lipid sink as a mechanism for the reversal of local anesthetic systemic toxicity: a physiologically based pharmacokinetic model study.

Anesthesiology, 118(6), 1350–1361.

By: I. Kuo* & B. Akpa*

Contributors: I. Kuo* & B. Akpa*

MeSH headings : Anesthetics, Local / pharmacokinetics; Anesthetics, Local / toxicity; Area Under Curve; Blood Pressure / drug effects; Bupivacaine / pharmacokinetics; Bupivacaine / toxicity; Fat Emulsions, Intravenous / therapeutic use; Heart Rate / drug effects; Humans; Infusions, Intravenous; Models, Biological; Reference Values; Reproducibility of Results
TL;DR: This initial study suggests that the lipid sink is insufficient to guarantee a reversal of systemic toxicity, with the timescale on which tissue content is reduced varies from organ to organ. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: May 18, 2019

2012 journal article

Solvent effects in the hydrogenation of 2-butanone

Journal of Catalysis, 289, 30–41.

Contributors: B. Akpa*, . C. D'Agostino, L. Gladden*, K. Hindle*, H. Manyar*, J. McGregor*, R. Li*, M. Neurock* ...

author keywords: Solvent effects; Mixed solvents; Mass transfer; Heterogeneous catalysis; Hydrogenation; 2-Butanone; Ru; DFT
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: July 20, 2019

2011 journal article

Fractional Order Analysis of Sephadex Gel Structures: NMR Measurements Reflecting Anomalous Diffusion.

Communications in Nonlinear Science & Numerical Simulation, 16(12), 4581–4587.

Contributors: R. Magin*, B. Akpa*, T. Neuberger* & A. Webb*

author keywords: Diffusion; Exponential; Fractional derivative; Fractal; Magnetic resonance; Sephadex gel
TL;DR: The fractional order decay model was fit to the diffusion-weighted signal attenuation for a range of b-values, and the parameters β, μ and D, were found to correlate with the porosity and tortuosity of the gel structure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: May 18, 2019

2011 journal article

Lipid resuscitation: a life-saving antidote for local anesthetic toxicity.

Current Pharmaceutical Biotechnology, 12(2), 313–319.

By: S. Bern*, B. Akpa*, I. Kuo* & G. Weinberg

Contributors: S. Bern*, B. Akpa*, I. Kuo* & G. Weinberg

author keywords: Fat emulsion; heart arrest; intravenous; local anesthetics; overdose; resuscitation; toxicity
MeSH headings : Anesthesia, Conduction / adverse effects; Anesthetics, Local / administration & dosage; Anesthetics, Local / adverse effects; Anesthetics, Local / toxicity; Animals; Bupivacaine / administration & dosage; Bupivacaine / adverse effects; Bupivacaine / toxicity; Disease Models, Animal; Fat Emulsions, Intravenous / administration & dosage; Fat Emulsions, Intravenous / pharmacology; Fat Emulsions, Intravenous / therapeutic use; Female; Heart Arrest / chemically induced; Heart Arrest / drug therapy; Humans; Male; Rats
TL;DR: Increased physician awareness and education, as well as optimized treatment protocols, will significantly reduce the rate of morbidity and mortality from local anesthetic toxicity. (via Semantic Scholar)
Source: ORCID
Added: May 18, 2019

2009 conference paper

Fractional order NMR reflects anomalous diffusion

ETFA 2009 - 2009 IEEE Conference on Emerging Technologies and Factory Automation.

TL;DR: It is demonstrated that fractional calculus (FC) can be successfully applied to analyze diffusion images of sephadex gels and brain tissues from healthy humans in vivo and may lead to a new way to investigate tissue structural changes in disease. (via Semantic Scholar)
Source: ORCID
Added: April 7, 2020

2009 journal article

Vesicle formation and endocytosis: function, machinery, mechanisms, and modeling.

Antioxidants & Redox Signaling, 11(6), 1301–1312.

By: N. Parkar*, B. Akpa*, L. Nitsche*, L. Wedgewood*, A. Place*, M. Sverdlov*, O. Chaga*, R. Minshall*

Contributors: N. Parkar*, B. Akpa*, L. Nitsche*, L. Wedgewood*, A. Place*, M. Sverdlov*, O. Chaga*, R. Minshall*

MeSH headings : Animals; Caveolae / metabolism; Caveolae / ultrastructure; Cell Membrane / metabolism; Cell Membrane / ultrastructure; Clathrin / metabolism; Endocytosis / genetics; Endocytosis / physiology; Humans; Models, Biological; Signal Transduction / physiology; Transport Vesicles / metabolism; Transport Vesicles / physiology; Transport Vesicles / ultrastructure
TL;DR: This review of endocytosis broadly discusses the structural and signaling proteins that compose the molecular machinery governing endocytic vesicle formation (budding, invagination, and fission from the membrane), with some regard for the specificity observed in certain cell types and species. (via Semantic Scholar)
Source: ORCID
Added: May 18, 2019

2008 conference paper

A computational and experimental investigation of mechanisms for caveolae-mediated endocytosis

AIChE Annual Meeting, Conference Proceedings. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952289953&partnerID=MN8TOARS

By: B. Akpa, L. Nitsche, L. Wedgewood & R. Minshall

Contributors: B. Akpa, L. Nitsche, L. Wedgewood & R. Minshall

Source: ORCID
Added: April 7, 2020

2008 chapter

Chapter 26. Magnetic Resonance Imaging: A New Window on the Catalyst Operating in the Reactor Environment

In Turning Points in Solid-State, Materials and Surface Science (pp. 457–478).

By: L. Gladden*, B. Akpa*, L. Anadon*, C. Dunckley*, M. Lim*, M. Mantle*, A. Sederman*

Sources: Crossref, NC State University Libraries
Added: July 20, 2019

2008 journal article

Non-invasive mass transfer measurements in complex biofilm-coated structures.

Biotechnology and Bioengineering, 101(3), 602–608.

By: D. Graf Von Der Schulenburg*, B. Akpa*, L. Gladden* & M. Johns*

Contributors: D. Graf Von Der Schulenburg*, B. Akpa*, L. Gladden* & M. Johns*

MeSH headings : Biofilms / growth & development; Biological Transport; Carbon Isotopes / analysis; Magnetic Resonance Spectroscopy / methods
TL;DR: A novel application of 13C pulsed field gradient NMR to monitor mass transfer in a 3D complex porous support structure modified by biofilm growth is demonstrated, enabling timescales an order of magnitude larger than previously possible to be accessed with respect to displacement probability distribution (propagator) measurements. (via Semantic Scholar)
Source: ORCID
Added: May 18, 2019

2008 conference paper

Quantitative, multinuclear magnetic resonance microscopy methods for the study of multiphase systems

AIChE Annual Meeting, Conference Proceedings. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952300806&partnerID=MN8TOARS

By: B. Akpa

Contributors: B. Akpa

Source: ORCID
Added: April 7, 2020

2008 conference paper

Study of miscible and immiscible flows in a microchannel using magnetic resonance imaging

AIChE Annual Meeting, Conference Proceedings. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952285034&partnerID=MN8TOARS

By: B. Akpa, S. Matthews, A. Sederman, K. Yunus, A. Fisher, M. Johns, L. Gladden

Contributors: B. Akpa, S. Matthews, A. Sederman, K. Yunus, A. Fisher, M. Johns, L. Gladden

Source: ORCID
Added: April 7, 2020

2007 journal article

Enhanced (13)C PFG NMR for the study of hydrodynamic dispersion in porous media.

Journal of Magnetic Resonance (San Diego, Calif. : 1997), 186(1), 160–165.

author keywords: propagators; C-13 DEPT; PGSE NMR; porous media; hydrodynamic dispersion
MeSH headings : Carbon Isotopes / chemistry; Colloids / chemistry; Complex Mixtures / chemistry; Magnetic Resonance Spectroscopy / methods; Nephelometry and Turbidimetry / methods; Porosity; Signal Processing, Computer-Assisted; Water / chemistry
TL;DR: A heteronuclear approach to PFG NMR is demonstrated which allows the study of molecular displacement over extended time scales (and, consequently, length scales) by exploiting the longer relaxation time of (13)C. (via Semantic Scholar)
Source: ORCID
Added: May 18, 2019

2007 journal article

Simulation of miscible diffusive mixing in microchannels

Sensors and Actuators B: Chemical, 123(2), 1142–1152.

By: S. Sullivan*, B. Akpa*, S. Matthews*, A. Fisher*, L. Gladden* & M. Johns*

Contributors: S. Sullivan*, B. Akpa*, S. Matthews*, A. Fisher*, L. Gladden* & M. Johns*

author keywords: microchannel; analyte; LB; lattice Boltzmann; miscible; simulation
Sources: Crossref, NC State University Libraries, ORCID
Added: July 20, 2019

2007 journal article

Study of miscible and immiscible flows in a microchannel using magnetic resonance imaging.

Analytical Chemistry, 79(16), 6128–6134.

By: B. Akpa*, S. Matthews*, A. Sederman*, K. Yunus*, A. Fisher*, M. Johns*, L. Gladden*

Contributors: B. Akpa*, S. Matthews*, A. Sederman*, K. Yunus*, A. Fisher*, M. Johns*, L. Gladden*

MeSH headings : Diffusion; Magnetic Resonance Imaging / methods; Microfluidic Analytical Techniques / methods; Microfluidics
TL;DR: MRI has been used for the first time to obtain both cross-sectional velocity and concentration maps of flow through an optically opaque Y-shaped microfluidic sensor via the multidimensional spatial resolution of flow and mass transfer. (via Semantic Scholar)
Source: ORCID
Added: May 18, 2019

2006 journal article

Distribution of surfactants in latex films: a Rutherford Backscattering study.

Langmuir : the ACS Journal of Surfaces and Colloids, 22(12), 5314–5320.

By: W. Lee*, V. Gundabala*, B. Akpa*, M. Johns*, C. Jeynes* & A. Routh*

Contributors: W. Lee*, V. Gundabala*, B. Akpa*, M. Johns*, C. Jeynes* & A. Routh*

TL;DR: The accumulation of surfactant on the surface of poly(styrene-co-butyl acrylate) latex is studied using Rutherford Backscattering (RBS) and compared with results from a model that is based on the diffusive transport of particles and surfactants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: May 18, 2019

2006 journal article

Dynamic Mr Imaging of Single- and Two-Phase Flows

Chemical Engineering Research and Design, 84(4), 272–281.

By: L. Gladden*, B. Akpa*, L. Anadon*, J. Heras*, D. Holland*, M. Mantle*, S. Matthews*, C. Mueller* ...

Contributors: L. Gladden*, B. Akpa*, L. Anadon*, J. Heras*, D. Holland*, M. Mantle*, S. Matthews*, C. Mueller*, M. Sains*, A. Sederman*

author keywords: magnetic resonance imaging; reaction engineering; multi-phase flow
Sources: Crossref, NC State University Libraries, ORCID
Added: July 20, 2019

2006 chapter

Reactors and Reactions: In Situ Reaction Imaging in Fixed-bed Reactors Using MRI

In NMR Imaging in Chemical Engineering (pp. 590–608).

By: L. Gladden*, B. Akpa*, M. Mantle* & A. Sederman*

Contributors: L. Gladden*, B. Akpa*, M. Mantle* & A. Sederman*

Source: ORCID
Added: April 7, 2020

2005 journal article

In situ 13C DEPT-MRI as a tool to spatially resolve chemical conversion and selectivity of a heterogeneous catalytic reaction occurring in a fixed-bed reactor.

Chemical Communications (Cambridge, England), (21), 2741–2743.

By: B. Akpa*, M. Mantle*, A. Sederman* & L. Gladden*

Contributors: B. Akpa*, M. Mantle*, A. Sederman* & L. Gladden*

TL;DR: The distortionless enhancement by polarisation transfer (DEPT) nuclear magnetic resonance (NMR) technique, combined with magnetic resonance imaging (MRI), has been used to provide the first in situ spatially-resolved and quantitative measurement of chemical conversion and selectivity within a fixed-bed reactor using natural abundance 13C NMR. (via Semantic Scholar)
Source: ORCID
Added: May 18, 2019

Employment

Updated: October 16th, 2020 14:52

2020 - present

Oak Ridge National Laboratory Oak Ridge, Tennessee, US
Senior Research Scientist

2020 - present

The University of Tennessee-Knoxville Knoxville, TN, US
Joint Associate Professor Chemical and Biomolecular Engineering

2015 - 2020

North Carolina State University Raleigh, NC, US
Assistant Professor Molecular Biomedical Sciences

2009 - 2015

University of Illinois at Chicago Chicago, IL, US
Assistant Professor Chemical Engineering

2007 - 2009

University of Illinois at Chicago Chicago, IL, US
Postdoctoral Research Fellow Chemical Engineering

Education

Updated: April 6th, 2020 15:09

University of Cambridge Cambridge, Cambridgeshire, GB
PhD with Advanced Chemical Engineering Practice Chemical Engineering

University of Cambridge Cambridge, Cambridgeshire, GB
BA & MEng Chemical Engineering

Funding History

Funding history based on the linked ORCID record. Updated: May 8th, 2022 20:58

grant January 1, 2022 - December 31, 2024
Collaborative Research: Living on the Edge - Quantitative Systems Physiology of Iron Homeostasis
Directorate for Biological Sciences
grant August 1, 2019 - July 31, 2022
Vacuole remodeling in guard cells during stomata movements
Directorate for Biological Sciences
grant July 26, 2016 - August 29, 2017
A systems biology approach to assess host transcriptomics and virus kinetics in reproductive replacement gilts in the face of Porcine Reproductive and Respiratory Syndrome (PRRS)
National Institute of Food and Agriculture
grant September 1, 2012 - August 31, 2015
BRIGE: Colloidal scavengers for the reversal of drug toxicity
Directorate for Engineering

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