Works (38)

Updated: August 3rd, 2023 21:15

2022 article

A roadmap towards equitable hiring to diversify biomedical engineering faculty

Cosgriff-Hernandez, E., Aguado, B. A., Akpa, B. S., Fleming, G. C., Moore, E., Porras, A. M., … Bowden, A. (2022, June 16). (Vol. 6). Vol. 6.

By: E. Cosgriff-Hernandez, B. Aguado, B. Akpa, G. Fleming, E. Moore, A. Porras, P. Boyle, D. Chan ...

Source: ORCID
Added: July 2, 2022

2022 journal article

Cholesterol-induced suppression of Kir2 channels is mediated by decoupling at the inter-subunit interfaces

ISCIENCE, 25(5).

By: N. Barbera*, S. Granados*, C. Vanoye*, T. Abramova*, D. Kulbak*, S. Ahn*, A. George*, B. Akpa n, I. Levitan*

Sources: ORCID, Web Of Science
Added: May 9, 2022

2021 article

Predicting Inter-individual Variability During Lipid Resuscitation of Bupivacaine Cardiotoxicity in Rats: A Virtual Population Modeling Study

McDaniel, M., Flores, K. B., & Akpa, B. S. (2021, July 19). DRUGS IN R&D, Vol. 7.

By: M. McDaniel n, K. Flores n & B. Akpa n

MeSH headings : Anesthetics, Local / toxicity; Animals; Bupivacaine / toxicity; Cardiotoxicity; Lipids; Rats; Rats, Sprague-Dawley
Sources: ORCID, Web Of Science
Added: July 20, 2021

2021 review

Solving the puzzle of Fe homeostasis by integrating molecular, mathematical, and societal models

[Review of ]. CURRENT OPINION IN PLANT BIOLOGY, 64.

By: C. Hodgens n, B. Akpa* & T. Long n

author keywords: Iron homeostasis; Simulation-based inference (SBI); Inclusivity
MeSH headings : Biological Transport; Gene Expression Regulation, Plant; Homeostasis; Iron / metabolism; Plants / genetics; Plants / metabolism
Sources: ORCID, Web Of Science
Added: November 27, 2021

2020 chapter

Utility of stable isotope ratios of tap water and human hair in determining region of origin in Central and Southern Mexico

In Forensic Science and Humanitarian Action.

Source: ORCID
Added: April 7, 2020

2019 journal article

Molecular Dynamics Simulations of Kir2.2 and Cholesterol Reveal State- and Concentration-Dependent Binding Sites

Biophysical Journal, 116(3), 41a.

By: N. Barbera*, M. Ayee*, B. Akpa n & I. Levitan

Sources: Crossref, ORCID
Added: December 16, 2019

2019 journal article

Oxygen and hydrogen isotopes in human hair and tap water: Modeling relationships in a modern Mexican population

Human Biology, 90(3), 197–211.

By: C. Juarez, R. Ramey, D. Flaherty & B. Akpa*

author keywords: delta H-2; delta O-18; MEXICO; TAP WATER; HAIR
Source: ORCID
Added: April 7, 2020

2018 journal article

Molecular Dynamics Simulations of Kir2.2 Interactions with an Ensemble of Cholesterol Molecules

BIOPHYSICAL JOURNAL, 115(7), 1264–1280.

By: N. Barbera*, M. Ayee*, B. Akpa n & I. Levitan*

MeSH headings : Binding Sites; Cholesterol / metabolism; Elasticity; Ion Channel Gating; Molecular Dynamics Simulation; Potassium Channels, Inwardly Rectifying / chemistry; Potassium Channels, Inwardly Rectifying / metabolism; Protein Binding; Protein Conformation
Sources: Web Of Science, ORCID
Added: October 16, 2018

2017 article

Differential Effects of Sterols on Ion Channels: Stereospecific Binding vs Stereospecific Response

STEROL REGULATION OF ION CHANNELS, Vol. 80, pp. 25–50.

By: N. Barbera*, M. Ayee*, B. Akpa n & I. Levitan*

MeSH headings : Cell Membrane / metabolism; Humans; Ion Channels / chemistry; Ion Channels / metabolism; Protein Binding; Stereoisomerism; Sterols / chemistry; Sterols / metabolism; Sterols / pharmacology; Substrate Specificity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Molecular-Scale Biophysical Modulation of an Endothelial Membrane by Oxidized Phospholipids

BIOPHYSICAL JOURNAL, 112(2), 325–338.

By: M. Ayee*, E. LeMaster*, T. Shentu*, D. Singh*, N. Barbera*, D. Soni*, C. Tiruppathi*, P. Subbaiah* ...

MeSH headings : Animals; Biomechanical Phenomena / drug effects; Cattle; Cell Membrane / chemistry; Cell Membrane / drug effects; Cell Membrane / metabolism; Endothelial Cells / cytology; Lipid Bilayers / chemistry; Lipid Bilayers / metabolism; Mechanical Phenomena / drug effects; Molecular Conformation; Molecular Dynamics Simulation; Phospholipid Ethers / chemistry; Phospholipid Ethers / pharmacology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Using spectral and cumulative spectral entropy to classify anomalous diffusion in Sephadex (TM) gels

COMPUTERS & MATHEMATICS WITH APPLICATIONS, 73(5), 765–774.

author keywords: Anomalous diffusion; Fractional derivative; Cumulative spectral entropy; Continuous time random walk; Magnetic resonance imaging; Sephadex (TM) gel
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Endothelial Membrane Modulation by OxLDL: Molecular-Scale Effects of Oxidation Products on Model Membranes

Biophysical Journal, 110(3), 81a.

By: M. Ayee*, E. LeMaster*, B. Akpa n & I. Levitan*

Sources: Crossref, ORCID
Added: September 4, 2020

2016 journal article

Molecular Dynamics Simulations of Kir2.2-Cholesterol Interactions

Biophysical Journal, 110(3), 186a.

By: N. Barbera*, M. Ayee, B. Akpa n & I. Levitan

Sources: Crossref, ORCID
Added: September 4, 2020

2016 journal article

Structural perturbation of a dipalmitoylphosphatidylcholine (DPPC) bilayer by warfarin and its bolaamphiphilic analogue: A molecular dynamics study

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 468, 227–237.

By: M. Ayee*, C. Roth* & B. Akpa n

author keywords: Bolaamphiphile; Bilayer; Anticoagulant; Toxicity; Permeation; Phospholipid; Warfarin; Brodifacoum; Defect; Hydroxycoumarin
MeSH headings : 1,2-Dipalmitoylphosphatidylcholine / chemistry; Lipid Bilayers / chemistry; Molecular Dynamics Simulation; Molecular Structure; Surface-Active Agents / chemistry; Warfarin / chemistry
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 article

The emerging threat of superwarfarins: history, detection, mechanisms, and countermeasures

COUNTERMEASURES AGAINST CHEMICAL THREATS, Vol. 1374, pp. 111–122.

By: D. Feinstein*, B. Akpa n, M. Ayee*, A. Boullerne*, D. Braun*, S. Brodsky*, D. Gidalevitz*, Z. Hauck* ...

author keywords: superwarfarins; brodifacoum; HPLC; lipid membrane; neuropathology; nephrotoxicity; intralipid
MeSH headings : Animals; Anticoagulants / adverse effects; Anticoagulants / analysis; Anticoagulants / chemistry; Biomarkers / analysis; Environmental Exposure / analysis; Humans; Kidney / drug effects; Kidney / pathology; Nervous System / drug effects; Nervous System / pathology; Warfarin / adverse effects; Warfarin / analysis; Warfarin / chemistry; Warfarin / poisoning
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Confusion About Infusion: Rational Volume Limits for Intravenous Lipid Emulsion During Treatment of Oral Overdoses.

Annals of Emergency Medicine, 66(2), 185–188.

By: M. Fettiplace*, B. Akpa*, I. Rubinstein* & G. Weinberg*

MeSH headings : Bupropion / poisoning; Drug Overdose / therapy; Fat Emulsions, Intravenous / administration & dosage; Fat Emulsions, Intravenous / therapeutic use; Humans; Lamotrigine; Triazines / poisoning
Source: ORCID
Added: May 18, 2019

2015 journal article

Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride micro-emulsion

Journal of Controlled Release, 198, 62–70.

By: M. Fettiplace*, K. Lis*, R. Ripper*, K. Kowal*, A. Pichurko*, D. Vitello*, I. Rubinstein*, D. Schwartz*, B. Akpa*, G. Weinberg*

author keywords: Lipid emulsion; Local anesthetic; Bupivacaine; Triglyceride; Antidote; Biodetoxification
MeSH headings : Animals; Bupivacaine / pharmacokinetics; Bupivacaine / toxicity; Cardiac Output / drug effects; Cardiotonic Agents / administration & dosage; Cardiotonic Agents / pharmacology; Cardiotonic Agents / therapeutic use; Cardiotoxicity / drug therapy; Cardiotoxicity / metabolism; Cardiotoxicity / physiopathology; Cardiotoxins / pharmacokinetics; Cardiotoxins / toxicity; Emulsions / administration & dosage; Emulsions / pharmacology; Emulsions / therapeutic use; Liver / metabolism; Models, Biological; Muscle, Skeletal / metabolism; Myocardium / metabolism; Phospholipids / administration & dosage; Phospholipids / pharmacology; Phospholipids / therapeutic use; Rats; Soybean Oil / administration & dosage; Soybean Oil / pharmacology; Soybean Oil / therapeutic use; Triglycerides / administration & dosage; Triglycerides / pharmacology; Triglycerides / therapeutic use
Source: ORCID
Added: May 18, 2019

2014 journal article

Resuscitation with lipid emulsion: dose-dependent recovery from cardiac pharmacotoxicity requires a cardiotonic effect.

Anesthesiology, 120(4), 915–925.

By: M. Fettiplace*, B. Akpa*, R. Ripper*, B. Zider*, J. Lang*, I. Rubinstein*, G. Weinberg

MeSH headings : Anesthetics, Local / toxicity; Animals; Bupivacaine / toxicity; Cardiotonic Agents / therapeutic use; Disease Models, Animal; Dose-Response Relationship, Drug; Fat Emulsions, Intravenous / therapeutic use; Heart / drug effects; Heart / physiopathology; Heart Arrest / chemically induced; Heart Arrest / therapy; Heart Rate / drug effects; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Resuscitation / methods; Sodium Chloride / administration & dosage; Time Factors; Treatment Outcome
Source: ORCID
Added: May 18, 2019

2013 conference paper

Positive inotropy - A likely mechanism for lipid reversal of local anesthetic toxicity

Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future, 535. http://www.scopus.com/inward/record.url?eid=2-s2.0-84911417408&partnerID=MN8TOARS

By: B. Akpa

Source: ORCID
Added: April 7, 2020

2013 conference paper

Sequestering of toxins for the reversal of drug toxicity: A coarse grained molecular dynamics study

Computational Molecular Science and Engineering Forum 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future, 248. http://www.scopus.com/inward/record.url?eid=2-s2.0-84911478625&partnerID=MN8TOARS

By: M. Ayee & B. Akpa

Source: ORCID
Added: April 7, 2020

2013 journal article

Validity of the lipid sink as a mechanism for the reversal of local anesthetic systemic toxicity: a physiologically based pharmacokinetic model study.

Anesthesiology, 118(6), 1350–1361.

By: I. Kuo* & B. Akpa*

MeSH headings : Anesthetics, Local / pharmacokinetics; Anesthetics, Local / toxicity; Area Under Curve; Blood Pressure / drug effects; Bupivacaine / pharmacokinetics; Bupivacaine / toxicity; Fat Emulsions, Intravenous / therapeutic use; Heart Rate / drug effects; Humans; Infusions, Intravenous; Models, Biological; Reference Values; Reproducibility of Results
Source: ORCID
Added: May 18, 2019

2012 journal article

Solvent effects in the hydrogenation of 2-butanone

Journal of Catalysis, 289, 30–41.

author keywords: Solvent effects; Mixed solvents; Mass transfer; Heterogeneous catalysis; Hydrogenation; 2-Butanone; Ru; DFT
Sources: Crossref, ORCID
Added: July 20, 2019

2011 journal article

Fractional Order Analysis of Sephadex Gel Structures: NMR Measurements Reflecting Anomalous Diffusion.

Communications in Nonlinear Science & Numerical Simulation, 16(12), 4581–4587.

author keywords: Diffusion; Exponential; Fractional derivative; Fractal; Magnetic resonance; Sephadex gel
Source: ORCID
Added: May 18, 2019

2011 journal article

Lipid resuscitation: a life-saving antidote for local anesthetic toxicity.

Current Pharmaceutical Biotechnology, 12(2), 313–319.

By: S. Bern, B. Akpa*, I. Kuo* & G. Weinberg

author keywords: Fat emulsion; heart arrest; intravenous; local anesthetics; overdose; resuscitation; toxicity
MeSH headings : Anesthesia, Conduction / adverse effects; Anesthetics, Local / administration & dosage; Anesthetics, Local / adverse effects; Anesthetics, Local / toxicity; Animals; Bupivacaine / administration & dosage; Bupivacaine / adverse effects; Bupivacaine / toxicity; Disease Models, Animal; Fat Emulsions, Intravenous / administration & dosage; Fat Emulsions, Intravenous / pharmacology; Fat Emulsions, Intravenous / therapeutic use; Female; Heart Arrest / chemically induced; Heart Arrest / drug therapy; Humans; Male; Rats
Source: ORCID
Added: May 18, 2019

2009 conference paper

Fractional order NMR reflects anomalous diffusion

ETFA 2009 - 2009 IEEE Conference on Emerging Technologies and Factory Automation.

Source: ORCID
Added: April 7, 2020

2009 journal article

Vesicle formation and endocytosis: function, machinery, mechanisms, and modeling.

Antioxidants & Redox Signaling, 11(6), 1301–1312.

By: N. Parkar*, B. Akpa*, L. Nitsche*, L. Wedgewood*, A. Place*, M. Sverdlov*, O. Chaga*, R. Minshall*

MeSH headings : Animals; Caveolae / metabolism; Caveolae / ultrastructure; Cell Membrane / metabolism; Cell Membrane / ultrastructure; Clathrin / metabolism; Endocytosis / genetics; Endocytosis / physiology; Humans; Models, Biological; Signal Transduction / physiology; Transport Vesicles / metabolism; Transport Vesicles / physiology; Transport Vesicles / ultrastructure
Source: ORCID
Added: May 18, 2019

2008 conference paper

A computational and experimental investigation of mechanisms for caveolae-mediated endocytosis

AIChE Annual Meeting, Conference Proceedings. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952289953&partnerID=MN8TOARS

By: B. Akpa, L. Nitsche, L. Wedgewood & R. Minshall

Source: ORCID
Added: April 7, 2020

2008 chapter

Chapter 26. Magnetic Resonance Imaging: A New Window on the Catalyst Operating in the Reactor Environment

In Turning Points in Solid-State, Materials and Surface Science (pp. 457–478).

By: L. Gladden*, B. Akpa*, L. Anadon*, C. Dunckley*, M. Lim*, M. Mantle*, A. Sederman*

Sources: Crossref, ORCID
Added: July 20, 2019

2008 journal article

Non-invasive mass transfer measurements in complex biofilm-coated structures.

Biotechnology and Bioengineering, 101(3), 602–608.

By: D. Graf Von Der Schulenburg*, B. Akpa*, L. Gladden* & M. Johns*

MeSH headings : Biofilms / growth & development; Biological Transport; Carbon Isotopes / analysis; Magnetic Resonance Spectroscopy / methods
Source: ORCID
Added: May 18, 2019

2008 conference paper

Quantitative, multinuclear magnetic resonance microscopy methods for the study of multiphase systems

AIChE Annual Meeting, Conference Proceedings. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952300806&partnerID=MN8TOARS

By: B. Akpa

Source: ORCID
Added: April 7, 2020

2008 conference paper

Study of miscible and immiscible flows in a microchannel using magnetic resonance imaging

AIChE Annual Meeting, Conference Proceedings. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952285034&partnerID=MN8TOARS

By: B. Akpa, S. Matthews, A. Sederman, K. Yunus, A. Fisher, M. Johns, L. Gladden

Source: ORCID
Added: April 7, 2020

2007 journal article

Enhanced (13)C PFG NMR for the study of hydrodynamic dispersion in porous media.

Journal of Magnetic Resonance (San Diego, Calif. : 1997), 186(1), 160–165.

author keywords: propagators; C-13 DEPT; PGSE NMR; porous media; hydrodynamic dispersion
MeSH headings : Carbon Isotopes / chemistry; Colloids / chemistry; Complex Mixtures / chemistry; Magnetic Resonance Spectroscopy / methods; Nephelometry and Turbidimetry / methods; Porosity; Signal Processing, Computer-Assisted; Water / chemistry
Source: ORCID
Added: May 18, 2019

2007 journal article

Simulation of miscible diffusive mixing in microchannels

Sensors and Actuators B: Chemical, 123(2), 1142–1152.

By: S. Sullivan*, B. Akpa*, S. Matthews*, A. Fisher*, L. Gladden* & M. Johns*

author keywords: microchannel; analyte; LB; lattice Boltzmann; miscible; simulation
Sources: Crossref, ORCID
Added: July 20, 2019

2007 journal article

Study of miscible and immiscible flows in a microchannel using magnetic resonance imaging.

Analytical Chemistry, 79(16), 6128–6134.

MeSH headings : Diffusion; Magnetic Resonance Imaging / methods; Microfluidic Analytical Techniques / methods; Microfluidics
Source: ORCID
Added: May 18, 2019

2006 journal article

Distribution of surfactants in latex films: a Rutherford Backscattering study.

Langmuir : the ACS Journal of Surfaces and Colloids, 22(12), 5314–5320.

By: W. Lee*, V. Gundabala*, B. Akpa*, M. Johns*, C. Jeynes* & A. Routh*

Source: ORCID
Added: May 18, 2019

2006 journal article

Dynamic Mr Imaging of Single- and Two-Phase Flows

Chemical Engineering Research and Design, 84(4), 272–281.

By: L. Gladden*, B. Akpa*, L. Anadon*, J. Heras*, D. Holland*, M. Mantle*, S. Matthews*, C. Mueller* ...

author keywords: magnetic resonance imaging; reaction engineering; multi-phase flow
Sources: Crossref, ORCID
Added: July 20, 2019

2006 chapter

Reactors and Reactions: In Situ Reaction Imaging in Fixed-bed Reactors Using MRI

In NMR Imaging in Chemical Engineering (pp. 590–608).

By: L. Gladden*, B. Akpa*, M. Mantle* & A. Sederman*

Source: ORCID
Added: April 7, 2020

2005 journal article

In situ 13C DEPT-MRI as a tool to spatially resolve chemical conversion and selectivity of a heterogeneous catalytic reaction occurring in a fixed-bed reactor.

Chemical Communications (Cambridge, England), (21), 2741–2743.

By: B. Akpa*, M. Mantle*, A. Sederman* & L. Gladden*

Source: ORCID
Added: May 18, 2019

Employment

Updated: October 16th, 2020 14:52

2020 - present

Oak Ridge National Laboratory Oak Ridge, Tennessee, US
Senior Research Scientist

2020 - present

The University of Tennessee-Knoxville Knoxville, TN, US
Joint Associate Professor Chemical and Biomolecular Engineering

2015 - 2020

North Carolina State University Raleigh, NC, US
Assistant Professor Molecular Biomedical Sciences

2009 - 2015

University of Illinois at Chicago Chicago, IL, US
Assistant Professor Chemical Engineering

2007 - 2009

University of Illinois at Chicago Chicago, IL, US
Postdoctoral Research Fellow Chemical Engineering

Education

Updated: April 6th, 2020 15:09

University of Cambridge Cambridge, Cambridgeshire, GB
PhD with Advanced Chemical Engineering Practice Chemical Engineering

University of Cambridge Cambridge, Cambridgeshire, GB
BA & MEng Chemical Engineering

Funding History

Funding history based on the linked ORCID record. Updated: May 8th, 2022 20:58

grant January 1, 2022 - December 31, 2024
Collaborative Research: Living on the Edge - Quantitative Systems Physiology of Iron Homeostasis
Directorate for Biological Sciences
grant August 1, 2019 - July 31, 2022
Vacuole remodeling in guard cells during stomata movements
Directorate for Biological Sciences
grant July 26, 2016 - August 29, 2017
A systems biology approach to assess host transcriptomics and virus kinetics in reproductive replacement gilts in the face of Porcine Reproductive and Respiratory Syndrome (PRRS)
National Institute of Food and Agriculture
grant September 1, 2012 - August 31, 2015
BRIGE: Colloidal scavengers for the reversal of drug toxicity
Directorate for Engineering