Bharadwaja Peddinti

College of Engineering

Works (4)

Updated: September 26th, 2023 05:01

2023 journal article

Preventing the spread of life-threatening gastrointestinal microbes on the surface of a continuously self-disinfecting block polymer

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 652, 718–726.

By: K. Wells n, Y. Ciftci*, B. Peddinti n, R. Ghiladi n , G. Vediyappan *, R. Spontak n , R. Govind *

author keywords: Anionic block polymer; Clostridioides difficile; Candida auris; Candida albicans; Antimicrobial; Self-disinfecting; Broad-spectrum; Infection prevention
TL;DR: It is demonstrated that highly persistent, drug-resistant and transmissible healthcare pathogens such as Clostridioides difficile and Candida auris can be rapidly inactivated on the solid surface of a self-disinfecting anionic block polymer that inherently generates a water surface layer that is highly acidic (pH < 1) upon hydration. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: September 25, 2023

2021 journal article

Rapid and Repetitive Inactivation of SARS-CoV-2 and Human Coronavirus on Self-Disinfecting Anionic Polymers

ADVANCED SCIENCE, 8(11).

By: B. Peddinti n, S. Downs *, J. Yan n , S. Smith *, R. Ghiladi n , V. Mhetar*, R. Tocchetto*, A. Griffiths *, F. Scholle n, R. Spontak n 

author keywords: antiviral materials; charged block polymers; microphase&#8208; ordered materials; polyanions; thermoplastic elastomers
MeSH headings : COVID-19 / prevention & control; COVID-19 / transmission; COVID-19 / virology; Disinfectants / therapeutic use; Humans; Pandemics; Polymers / chemistry; Polymers / therapeutic use; SARS-CoV-2 / drug effects; SARS-CoV-2 / pathogenicity
TL;DR: It is demonstrated that an architecturally‐ and chemically‐diverse family of nanostructured anionic polymers yield a rapid and continuous disinfecting alternative to inactivate coronaviruses and prevent their transmission from contact with contaminated surfaces. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021

2021 journal article

Toward Universal Photodynamic Coatings for Infection Control

FRONTIERS IN MEDICINE, 8.

By: C. Ghareeb n, B. Peddinti n, S. Kisthardt n, F. Scholle n, R. Spontak n  & R. Ghiladi n 

author keywords: antimicrobial; Coronavirus; coatings; photodynamic inactivation; photosensitizer; polymer; singlet oxygen; Staphylococcus aureus
TL;DR: The antimicrobial efficacy of a simple bicomponent spray coating composed of the commercially-available UV-photocrosslinkable polymer N-methyl-4(4'-formyl-styryl)pyridinium methosulfate acetal poly(vinyl alcohol) (SbQ-PVA) and one of three aPDI photosensitizers (PSs) is evaluated. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 23, 2021

2020 journal article

Photodynamic Coatings on Polymer Microfibers for Pathogen Inactivation: Effects of Application Method and Composition

ACS Applied Materials & Interfaces, 13(1), 155–163.

By: B. Peddinti n, N. Morales-Gagnon n, B. Pourdeyhimi n , F. Scholle n, R. Spontak n  & R. Ghiladi n 

author keywords: hospital-acquired infections; photodynamic coatings; porphyrin photosensitizer; SARS-CoV-2 virus; polymer microfibers
MeSH headings : COVID-19 / prevention & control; COVID-19 / virology; Escherichia coli / drug effects; Escherichia coli / pathogenicity; Humans; Iatrogenic Disease / prevention & control; Light; Methicillin-Resistant Staphylococcus aureus / drug effects; Methicillin-Resistant Staphylococcus aureus / pathogenicity; Microfibrils / chemistry; Pandemics; Photosensitizing Agents / chemistry; Photosensitizing Agents / pharmacology; Polymers / chemistry; Polymers / pharmacology; Porphyrins / chemistry; Porphyrins / pharmacology; SARS-CoV-2 / drug effects; SARS-CoV-2 / pathogenicity; Singlet Oxygen
TL;DR: These coated fibers can inactivate a human common cold coronavirus serving as a surrogate for the SARS-CoV-2 virus and are confirmed to be able to inactivate antibiotic-resistant bacteria. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: January 31, 2021

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