Brian O'Callaghan Diekman

Comet assay for quantification of the increased DNA damage burden in primary human chondrocytes with aging and osteoarthritis

Copp, M. E., Chubinskaya, S., Bracey, D. N., Shine, J., Sessions, G., Loeser, R. F., & Diekman, B. O. (2022, August 22). AGING CELL.

Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice

NATURE COMMUNICATIONS.

Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes

FREE RADICAL BIOLOGY AND MEDICINE, 166, 90–103.

The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence

OSTEOARTHRITIS AND CARTILAGE, 29(3), 402–412.

Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation

JCI INSIGHT, 5(4).

Deletion ofJNKEnhances Senescence in Joint Tissues and Increases the Severity of Age-Related Osteoarthritis in Mice

ARTHRITIS & RHEUMATOLOGY, Vol. 72, pp. 1679–1688.

Dynamic interplay between connective tissues and the surrounding environment during aging

CONNECTIVE TISSUE RESEARCH, Vol. 61, pp. 1–3.

Microfluidics for the study of mechanotransduction

JOURNAL OF PHYSICS D-APPLIED PHYSICS, 53(22).

Reply

ARTHRITIS & RHEUMATOLOGY.

Cells exhibiting strong p16(INK4a) promoter activation in vivo display features of senescence

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(7), 2603–2611.

Engineered Cartilage from Human Chondrocytes with Homozygous Knockout of Cell Cycle Inhibitor p21

TISSUE ENGINEERING PART A.

p16(Ink4a) deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence

MATRIX BIOLOGY, 82, 54–70.

Targeting aging for disease modification in osteoarthritis

[Review of ]. Current Opinion in Rheumatology, 30(1), 101–107.