Brian O'Callaghan Diekman
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Works (18)
Updated: August 31st, 2023 05:00
2023 review
Epigenetics as a mediator of genetic risk in osteoarthritis: role during development, homeostasis, aging, and disease progression
[Review of ]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 324(5), C1078–C1088.
author keywords: epigenetics; genetics; GWAS; osteoarthritis
MeSH headings : Adult; Humans; Genetic Predisposition to Disease / genetics; Genome-Wide Association Study; Epigenesis, Genetic / genetics; Aging / genetics; Homeostasis / genetics; Osteoarthritis / genetics; Risk Factors; Disease Progression
Source: Web Of Science
Added: June 12, 2023
2023 journal article
Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics
ACTA BIOMATERIALIA, 166, 346–359.
author keywords: Vascular Ehlers-Danlos syndrome; Cell derived matrix; Collagen III; Mechanotransduction; ECM mechanics; Viscoelasticity
doi.org (publisher)
Source: Web Of Science
Added: August 7, 2023
2023 journal article
Yes-associated protein nuclear translocation promotes anabolic activity in human articular chondrocytes
OSTEOARTHRITIS AND CARTILAGE, 31(8), 1078–1090.
author keywords: Yes-associated protein; Nuclear translocation; Differential phosphorylation; Mechanotransduction; Chondrocytes
Source: Web Of Science
Added: August 28, 2023
2022 article
3D chromatin structure in chondrocytes identifies putative osteoarthritis risk genes
Thulson, E., Davis, E. S., D'Costa, S., Coryell, P. R., Kramer, N. E., Mohlke, K. L., … Phanstiel, D. H. (2022, September 13). GENETICS.
author keywords: 3D chromatin structure; genome-wide association studies; osteoarthritis; genomics
MeSH headings : Humans; Chondrocytes; Fibronectins / genetics; Fibronectins / metabolism; Genome-Wide Association Study; Osteoarthritis / genetics; Osteoarthritis / metabolism; Chromatin / genetics; Chromatin / metabolism
Source: Web Of Science
Added: December 5, 2022
2022 article
Comet assay for quantification of the increased DNA damage burden in primary human chondrocytes with aging and osteoarthritis
Copp, M. E., Chubinskaya, S., Bracey, D. N., Shine, J., Sessions, G., Loeser, R. F., & Diekman, B. O. (2022, August 22). AGING CELL.
author keywords: arthritis; cartilage; single-cell gel electrophoresis
MeSH headings : Adult; Aged; Aging / genetics; Cadaver; Cartilage, Articular / metabolism; Cells, Cultured; Chondrocytes / metabolism; Comet Assay; DNA Damage / genetics; Humans; Middle Aged; Osteoarthritis / genetics; Osteoarthritis / metabolism
Source: Web Of Science
Added: September 6, 2022
2022 journal article
Pilot comparison of outcome measures across chemical and surgical experimental models of chronic osteoarthritis in the rat (Rattus norvegicus)
PLOS ONE, 17(11).
Ed(s): A. Wijnen
MeSH headings : Rats; Animals; Rats, Sprague-Dawley; Lameness, Animal; Disease Models, Animal; Osteoarthritis / complications; Pain / complications; Models, Anatomic; Outcome Assessment, Health Care
Sources: Web Of Science, ORCID
Added: November 22, 2022
2021 journal article
Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice
NATURE COMMUNICATIONS, 12(1).
MeSH headings : Aggrecans / metabolism; Aging / drug effects; Aging / metabolism; Animals; Annulus Fibrosus / drug effects; Annulus Fibrosus / metabolism; Annulus Fibrosus / pathology; Cell Survival / drug effects; Cellular Senescence / drug effects; Dasatinib / therapeutic use; Extracellular Matrix / drug effects; Extracellular Matrix / metabolism; Fibrosis; Inflammation; Intervertebral Disc Degeneration / drug therapy; Intervertebral Disc Degeneration / metabolism; Intervertebral Disc Degeneration / pathology; Mice; Mice, Inbred C57BL; Nucleus Pulposus / drug effects; Nucleus Pulposus / metabolism; Nucleus Pulposus / pathology; Phenotype; Quercetin / therapeutic use; Transcriptome / drug effects
Source: Web Of Science
Added: September 20, 2021
2021 journal article
Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes
FREE RADICAL BIOLOGY AND MEDICINE, 166, 90–103.
author keywords: Sirtuin; Aging; Oxidative stress; Antioxidant; Redox signaling; Osteoarthritis
MeSH headings : Aged; Animals; Biological Phenomena; Cartilage, Articular / metabolism; Chondrocytes; Homeostasis; Humans; Hydrogen Peroxide / metabolism; Mice; Oxidation-Reduction; Oxidative Stress; Sirtuins / genetics; Sirtuins / metabolism
Source: Web Of Science
Added: April 12, 2021
2021 journal article
The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence
OSTEOARTHRITIS AND CARTILAGE, 29(3), 402–412.
author keywords: SA-beta-gal; DNA damage; Osteoarthritis; Aging; TGF- beta 1; bFGF
MeSH headings : Animals; Ankle Joint; Cartilage, Articular / cytology; Cartilage, Articular / drug effects; Cartilage, Articular / metabolism; Cellular Senescence / drug effects; Cellular Senescence / genetics; Chemokine CCL2 / drug effects; Chemokine CCL2 / genetics; Chondrocytes / drug effects; Chondrocytes / metabolism; Cyclin-Dependent Kinase Inhibitor p16 / drug effects; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; DNA Damage / genetics; Fibroblast Growth Factor 2 / pharmacology; Gene Expression / drug effects; Histones / drug effects; Histones / metabolism; Horses; Humans; In Vitro Techniques; Inflammation / genetics; Insulin-Like Growth Factor Binding Protein 3 / drug effects; Insulin-Like Growth Factor Binding Protein 3 / genetics; Interleukin-6 / genetics; Matrix Metalloproteinase 13 / drug effects; Matrix Metalloproteinase 13 / genetics; Mitogens / pharmacology; Stifle; Transforming Growth Factor beta1 / pharmacology; beta-Galactosidase / drug effects; beta-Galactosidase / metabolism
Source: Web Of Science
Added: March 29, 2021
2020 journal article
Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation
JCI INSIGHT, 5(4).
MeSH headings : Actin-Related Protein 2-3 Complex / antagonists & inhibitors; Actin-Related Protein 2-3 Complex / metabolism; Adaptation, Physiological; Animals; Cartilage, Articular / metabolism; Cartilage, Articular / pathology; Intervertebral Disc / metabolism; Intervertebral Disc / pathology; Mice; Mice, Mutant Strains; Osmoregulation; Transcription Factors / metabolism
Source: Web Of Science
Added: March 23, 2020
2020 journal article
Deletion ofJNKEnhances Senescence in Joint Tissues and Increases the Severity of Age-Related Osteoarthritis in Mice
ARTHRITIS & RHEUMATOLOGY, 72(10), 1679–1688.
MeSH headings : Aging / metabolism; Animals; Cartilage, Articular / metabolism; Cellular Senescence / genetics; Chondrocytes / metabolism; Disease Models, Animal; Knee Joint / metabolism; Matrix Metalloproteinase 13 / metabolism; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 8 / genetics; Mitogen-Activated Protein Kinase 8 / metabolism; Mitogen-Activated Protein Kinase 9 / genetics; Mitogen-Activated Protein Kinase 9 / metabolism; Osteoarthritis / diagnosis; Osteoarthritis / genetics; Osteoarthritis / metabolism; Severity of Illness Index
Source: Web Of Science
Added: September 14, 2020
2020 article
Dynamic interplay between connective tissues and the surrounding environment during aging
Diekman, B. O. C. (2020, January 2). CONNECTIVE TISSUE RESEARCH, Vol. 61, pp. 1–3.
MeSH headings : Aging / physiology; Connective Tissue / physiology; Humans
Source: Web Of Science
Added: December 16, 2019
2020 journal article
Engineered Cartilage from Human Chondrocytes with Homozygous Knockout of Cell Cycle Inhibitor p21
TISSUE ENGINEERING PART A, 26(7-8), 441–449.
author keywords: genome editing; CRISPR; regeneration; tissue engineering
MeSH headings : Blotting, Western; Chondrocytes / cytology; Chondrocytes / metabolism; Clustered Regularly Interspaced Short Palindromic Repeats / genetics; Cyclin-Dependent Kinase Inhibitor p21 / genetics; Cyclin-Dependent Kinase Inhibitor p21 / metabolism; Gene Editing; Glycosaminoglycans / metabolism; Humans; Immunohistochemistry; Polymerase Chain Reaction; Tissue Engineering / methods
Source: Web Of Science
Added: December 9, 2019
2020 journal article
Microfluidics for the study of mechanotransduction
JOURNAL OF PHYSICS D-APPLIED PHYSICS, 53(22).
author keywords: microfluidics; mechanotransduction; mechanobiology; microfabrication; cell adhesion; biofluids; microdevices
Source: Web Of Science
Added: April 20, 2020
2020 personal communication
Reply
Loeser, R. F., Collins, J. A., Diekman, B. O., & Carlson, C. S. (2020, December).
MeSH headings : Animals; Mice; Osteoarthritis
Source: Web Of Science
Added: October 19, 2020
2019 journal article
Cells exhibiting strong p16(INK4a) promoter activation in vivo display features of senescence
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(7), 2603–2611.
author keywords: senescence; cdkn2a; aging
MeSH headings : Animals; Cell Proliferation; Cellular Senescence / genetics; Cyclin-Dependent Kinase Inhibitor p16 / genetics; Enzyme Activation; Fibroblasts / metabolism; Half-Life; Humans; Mice; Phenotype; Promoter Regions, Genetic; RNA, Messenger / genetics; beta-Galactosidase / metabolism
Source: Web Of Science
Added: February 25, 2019
2019 journal article
p16(Ink4a) deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence
MATRIX BIOLOGY, 82, 54–70.
author keywords: p16; p19; Ink4a; Senescence; Mouse models; Intervertebral disc degeneration; Aggrecan; Extracellular matrix; Nucleus pulposus; Aging; SASP
MeSH headings : Aggrecans / metabolism; Aging / genetics; Aging / metabolism; Animals; Cellular Senescence; Collagen / metabolism; Cyclin-Dependent Kinase Inhibitor p16 / genetics; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; Disease Models, Animal; Extracellular Matrix / metabolism; Gene Deletion; Homeostasis; Humans; Intervertebral Disc Degeneration / genetics; Intervertebral Disc Degeneration / metabolism; Mice; Phenotype
Source: Web Of Science
Added: September 23, 2019
2018 review
Targeting aging for disease modification in osteoarthritis
[Review of ]. CURRENT OPINION IN RHEUMATOLOGY, 30(1), 101–107.
author keywords: aging; cell senescence; cell signaling; mitochondria; reactive oxygen species
MeSH headings : Aging / metabolism; Animals; Antioxidants / metabolism; Cellular Senescence; Gene Expression Regulation; Humans; Mitochondria / metabolism; NF-E2-Related Factor 2 / metabolism; Osteoarthritis / drug therapy; Osteoarthritis / metabolism; Oxidative Stress; Reactive Oxygen Species / metabolism; Signal Transduction
Source: Web Of Science
Added: August 6, 2018
