Brian O'Callaghan Diekman
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Works (15)
2022 article
3D chromatin structure in chondrocytes identifies putative osteoarthritis risk genes
Thulson, E., Davis, E. S., D'Costa, S., Coryell, P. R., Kramer, N. E., Mohlke, K. L., … Phanstiel, D. H. (2022, September 13). GENETICS.
author keywords: 3D chromatin structure; genome-wide association studies; osteoarthritis; genomics
doi.org (repository)
Source: Web Of Science
Added: December 5, 2022
2022 article
Comet assay for quantification of the increased DNA damage burden in primary human chondrocytes with aging and osteoarthritis
Copp, M. E., Chubinskaya, S., Bracey, D. N., Shine, J., Sessions, G., Loeser, R. F., & Diekman, B. O. (2022, August 22). AGING CELL.
author keywords: arthritis; cartilage; single-cell gel electrophoresis
Source: Web Of Science
Added: September 6, 2022
2022 journal article
Pilot comparison of outcome measures across chemical and surgical experimental models of chronic osteoarthritis in the rat (Rattus norvegicus)
PLOS ONE, 17(11).
Ed(s): A. Wijnen
Sources: Web Of Science, ORCID
Added: November 22, 2022
2021 journal article
Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice
NATURE COMMUNICATIONS, 12(1).
Source: Web Of Science
Added: September 20, 2021
2021 journal article
Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes
FREE RADICAL BIOLOGY AND MEDICINE, 166, 90–103.
author keywords: Sirtuin; Aging; Oxidative stress; Antioxidant; Redox signaling; Osteoarthritis
Source: Web Of Science
Added: April 12, 2021
2021 journal article
The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence
OSTEOARTHRITIS AND CARTILAGE, 29(3), 402–412.
author keywords: SA-beta-gal; DNA damage; Osteoarthritis; Aging; TGF- beta 1; bFGF
Source: Web Of Science
Added: March 29, 2021
2020 journal article
Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation
JCI INSIGHT, 5(4).
Source: Web Of Science
Added: March 23, 2020
2020 journal article
Deletion ofJNKEnhances Senescence in Joint Tissues and Increases the Severity of Age-Related Osteoarthritis in Mice
ARTHRITIS & RHEUMATOLOGY, 72(10), 1679–1688.
Source: Web Of Science
Added: September 14, 2020
2020 article
Dynamic interplay between connective tissues and the surrounding environment during aging
Diekman, B. O. C. (2020, January 2). CONNECTIVE TISSUE RESEARCH, Vol. 61, pp. 1–3.
Source: Web Of Science
Added: December 16, 2019
2020 journal article
Engineered Cartilage from Human Chondrocytes with Homozygous Knockout of Cell Cycle Inhibitor p21
TISSUE ENGINEERING PART A, 26(7-8), 441–449.
author keywords: genome editing; CRISPR; regeneration; tissue engineering
Source: Web Of Science
Added: December 9, 2019
2020 journal article
Microfluidics for the study of mechanotransduction
JOURNAL OF PHYSICS D-APPLIED PHYSICS, 53(22).
author keywords: microfluidics; mechanotransduction; mechanobiology; microfabrication; cell adhesion; biofluids; microdevices
Source: Web Of Science
Added: April 20, 2020
2020 personal communication
Reply
Loeser, R. F., Collins, J. A., Diekman, B. O., & Carlson, C. S. (2020, December).
Source: Web Of Science
Added: October 19, 2020
2019 journal article
Cells exhibiting strong p16(INK4a) promoter activation in vivo display features of senescence
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(7), 2603–2611.
author keywords: senescence; cdkn2a; aging
Source: Web Of Science
Added: February 25, 2019
2019 journal article
p16(Ink4a) deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence
MATRIX BIOLOGY, 82, 54–70.
author keywords: p16; p19; Ink4a; Senescence; Mouse models; Intervertebral disc degeneration; Aggrecan; Extracellular matrix; Nucleus pulposus; Aging; SASP
Source: Web Of Science
Added: September 23, 2019
2018 review
Targeting aging for disease modification in osteoarthritis
[Review of ]. CURRENT OPINION IN RHEUMATOLOGY, 30(1), 101–107.
author keywords: aging; cell senescence; cell signaling; mitochondria; reactive oxygen species
Source: Web Of Science
Added: August 6, 2018
