Works (15)

2022 article

3D chromatin structure in chondrocytes identifies putative osteoarthritis risk genes

Thulson, E., Davis, E. S., D'Costa, S., Coryell, P. R., Kramer, N. E., Mohlke, K. L., … Phanstiel, D. H. (2022, September 13). GENETICS.

author keywords: 3D chromatin structure; genome-wide association studies; osteoarthritis; genomics
Source: Web Of Science
Added: December 5, 2022

2022 article

Comet assay for quantification of the increased DNA damage burden in primary human chondrocytes with aging and osteoarthritis

Copp, M. E., Chubinskaya, S., Bracey, D. N., Shine, J., Sessions, G., Loeser, R. F., & Diekman, B. O. (2022, August 22). AGING CELL.

By: M. Copp, S. Chubinskaya*, D. Bracey*, J. Shine, G. Sessions*, R. Loeser*, B. Diekman

author keywords: arthritis; cartilage; single-cell gel electrophoresis
Source: Web Of Science
Added: September 6, 2022

2022 journal article

Pilot comparison of outcome measures across chemical and surgical experimental models of chronic osteoarthritis in the rat (Rattus norvegicus)

PLOS ONE, 17(11).

By: M. Williams, R. Meyers, L. Braxton, B. Diekman & B. Lascelles

Ed(s): A. Wijnen

Sources: Web Of Science, ORCID
Added: November 22, 2022

2021 journal article

Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice

NATURE COMMUNICATIONS, 12(1).

By: E. Novais*, V. Tran*, S. Johnston*, K. Darris*, A. Roupas*, G. Sessions*, I. Shapiro*, B. Diekman, M. Risbud*

Source: Web Of Science
Added: September 20, 2021

2021 journal article

Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes

FREE RADICAL BIOLOGY AND MEDICINE, 166, 90–103.

By: J. Collins*, M. Kapustina*, J. Bolduc*, J. Pike*, B. Diekman, K. Mix*, S. Chubinskaya*, E. Eroglu* ...

author keywords: Sirtuin; Aging; Oxidative stress; Antioxidant; Redox signaling; Osteoarthritis
Source: Web Of Science
Added: April 12, 2021

2021 journal article

The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence

OSTEOARTHRITIS AND CARTILAGE, 29(3), 402–412.

author keywords: SA-beta-gal; DNA damage; Osteoarthritis; Aging; TGF- beta 1; bFGF
Source: Web Of Science
Added: March 29, 2021

2020 journal article

Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation

JCI INSIGHT, 5(4).

By: S. Tessier*, A. Doolittle*, K. Sao*, J. Rotty*, J. Bear*, V. Ulici*, R. Loeser*, I. Shapiro*, B. Diekman, M. Risbud*

Source: Web Of Science
Added: March 23, 2020

2020 journal article

Deletion ofJNKEnhances Senescence in Joint Tissues and Increases the Severity of Age-Related Osteoarthritis in Mice

ARTHRITIS & RHEUMATOLOGY, 72(10), 1679–1688.

Source: Web Of Science
Added: September 14, 2020

2020 article

Dynamic interplay between connective tissues and the surrounding environment during aging

Diekman, B. O. C. (2020, January 2). CONNECTIVE TISSUE RESEARCH, Vol. 61, pp. 1–3.

By: B. Diekman

Source: Web Of Science
Added: December 16, 2019

2020 journal article

Engineered Cartilage from Human Chondrocytes with Homozygous Knockout of Cell Cycle Inhibitor p21

TISSUE ENGINEERING PART A, 26(7-8), 441–449.

By: S. D'Costa, M. Rich* & B. Diekman

author keywords: genome editing; CRISPR; regeneration; tissue engineering
Source: Web Of Science
Added: December 9, 2019

2020 journal article

Microfluidics for the study of mechanotransduction

JOURNAL OF PHYSICS D-APPLIED PHYSICS, 53(22).

author keywords: microfluidics; mechanotransduction; mechanobiology; microfabrication; cell adhesion; biofluids; microdevices
Source: Web Of Science
Added: April 20, 2020

2020 personal communication

Reply

Loeser, R. F., Collins, J. A., Diekman, B. O., & Carlson, C. S. (2020, December).

Source: Web Of Science
Added: October 19, 2020

2019 journal article

Cells exhibiting strong p16(INK4a) promoter activation in vivo display features of senescence

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(7), 2603–2611.

By: J. Liu*, G. Souroullas*, B. Diekman, J. Krishnamurthy*, B. Hall*, J. Sorrentino, J. Parker*, G. Sessions*, A. Gudkov*, N. Sharpless*

author keywords: senescence; cdkn2a; aging
Source: Web Of Science
Added: February 25, 2019

2019 journal article

p16(Ink4a) deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence

MATRIX BIOLOGY, 82, 54–70.

By: E. Novais*, B. Diekman, I. Shapiro* & M. Risbud*

author keywords: p16; p19; Ink4a; Senescence; Mouse models; Intervertebral disc degeneration; Aggrecan; Extracellular matrix; Nucleus pulposus; Aging; SASP
Source: Web Of Science
Added: September 23, 2019

2018 review

Targeting aging for disease modification in osteoarthritis

[Review of ]. CURRENT OPINION IN RHEUMATOLOGY, 30(1), 101–107.

By: J. Colins, B. Diekman & R. Loeser*

author keywords: aging; cell senescence; cell signaling; mitochondria; reactive oxygen species
Source: Web Of Science
Added: August 6, 2018