Brian Diekman

Diekman, B. O., & Loeser, R. F. (2024, February 27). DNA Damage and Cellular Senescence in Osteoarthritis: An Unexpected Role for Interferon Regulatory Factor 1 in Chondrocyte DNA Repair. ARTHRITIS & RHEUMATOLOGY. https://doi.org/10.1002/art.42822

Richard, D., Capellini, T. D., & Diekman, B. O. (2023). [Review of Epigenetics as a mediator of genetic risk in osteoarthritis: role during development, homeostasis, aging, and disease progression]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 324(5), C1078–C1088. https://doi.org/10.1152/ajpcell.00574.2022

Doherty, E. L., Aw, W. Y., Warren, E. C., Hockenberry, M., Whitworth, C. P., Krohn, G., … Polacheck, W. J. (2023). Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics. ACTA BIOMATERIALIA, 166, 346–359. https://doi.org/10.1016/j.actbio.2023.05.015

Miao, M. Z., Su, Q. P., Cui, Y., Bahnson, E. M., Li, G., Wang, M., … Loeser, R. F. (2023). Redox-active endosomes mediate α5β1 integrin signaling and promote chondrocyte matrix metalloproteinase production in osteoarthritis. SCIENCE SIGNALING, 16(809). https://doi.org/10.1126/scisignal.adf8299

Cui, Y., Miao, M. Z., Wang, M., Su, Q. P., Qiu, K., Arbeeva, L., … Loeser, R. F. (2023). Yes-associated protein nuclear translocation promotes anabolic activity in human articular chondrocytes. OSTEOARTHRITIS AND CARTILAGE, 31(8), 1078–1090. https://doi.org/10.1016/j.joca.2023.04.006

Thulson, E., Davis, E. S., D'Costa, S., Coryell, P. R., Kramer, N. E., Mohlke, K. L., … Phanstiel, D. H. (2022, September 13). 3D chromatin structure in chondrocytes identifies putative osteoarthritis risk genes. GENETICS. https://doi.org/10.1093/genetics/iyac141

Copp, M. E., Chubinskaya, S., Bracey, D. N., Shine, J., Sessions, G., Loeser, R. F., & Diekman, B. O. (2022, August 22). Comet assay for quantification of the increased DNA damage burden in primary human chondrocytes with aging and osteoarthritis. AGING CELL. https://doi.org/10.1111/acel.13698

Williams, M. D., Meyers, R. C., Braxton, L. A., Diekman, B., & Lascelles, B. D. X. (2022). Pilot comparison of outcome measures across chemical and surgical experimental models of chronic osteoarthritis in the rat (Rattus norvegicus). PLOS ONE, 17(11). https://doi.org/10.1371/journal.pone.0277943

Novais, E. J., Tran, V. A., Johnston, S. N., Darris, K. R., Roupas, A. J., Sessions, G. A., … Risbud, M. V. (2021). Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice. NATURE COMMUNICATIONS, 12(1). https://doi.org/10.1038/s41467-021-25453-2

Collins, J. A., Kapustina, M., Bolduc, J. A., Pike, J. F. W., Diekman, B. O., Mix, K., … Loeser, R. F. (2021). Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes. FREE RADICAL BIOLOGY AND MEDICINE, 166, 90–103. https://doi.org/10.1016/j.freeradbiomed.2021.01.054

Copp, M. E., Flanders, M. C., Gagliardi, R., Gilbertie, J. M., Sessions, G. A., Chubinskaya, S., … Diekman, B. O. (2021). The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence. OSTEOARTHRITIS AND CARTILAGE, 29(3), 402–412. https://doi.org/10.1016/j.joca.2020.11.004

Tessier, S., Doolittle, A. C., Sao, K., Rotty, J. D., Bear, J. E., Ulici, V., … Risbud, M. V. (2020). Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation. JCI INSIGHT, 5(4). https://doi.org/10.1172/jci.insight.131382

Loeser, R. F., Kelley, K. L., Armstrong, A., Collins, J. A., Diekman, B. O., & Carlson, C. S. (2020). Deletion ofJNKEnhances Senescence in Joint Tissues and Increases the Severity of Age-Related Osteoarthritis in Mice. ARTHRITIS & RHEUMATOLOGY, 72(10), 1679–1688. https://doi.org/10.1002/art.41312

Diekman, B. O. C. (2020, January 2). Dynamic interplay between connective tissues and the surrounding environment during aging. CONNECTIVE TISSUE RESEARCH, Vol. 61, pp. 1–3. https://doi.org/10.1080/03008207.2020.1682282

D'Costa, S., Rich, M. J., & Diekman, B. O. (2020). Engineered Cartilage from Human Chondrocytes with Homozygous Knockout of Cell Cycle Inhibitor p21. TISSUE ENGINEERING PART A, 26(7-8), 441–449. https://doi.org/10.1089/ten.tea.2019.0214

Griffith, C. M., Huang, S. A., Cho, C., Khare, T. M., Rich, M., Lee, G.-hun, … Polacheck, W. J. (2020). Microfluidics for the study of mechanotransduction. JOURNAL OF PHYSICS D-APPLIED PHYSICS, 53(22). https://doi.org/10.1088/1361-6463/ab78d4

Loeser, R. F., Collins, J. A., Diekman, B. O., & Carlson, C. S. (2020, December). Reply. https://doi.org/10.1002/art.41431

Liu, J.-Y., Souroullas, G. P., Diekman, B. O., Krishnamurthy, J., Hall, B. M., Sorrentino, J. A., … Sharpless, N. E. (2019). Cells exhibiting strong p16(INK4a) promoter activation in vivo display features of senescence. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(7), 2603–2611. https://doi.org/10.1073/pnas.1818313116

Novais, E. J., Diekman, B. O., Shapiro, I. M., & Risbud, M. V. (2019). p16(Ink4a) deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence. MATRIX BIOLOGY, 82, 54–70. https://doi.org/10.1016/j.matbio.2019.02.004

Colins, J. A., Diekman, B. O., & Loeser, R. F. (2018). [Review of Targeting aging for disease modification in osteoarthritis]. CURRENT OPINION IN RHEUMATOLOGY, 30(1), 101–107. https://doi.org/10.1097/bor.0000000000000456