Works (5)

Updated: July 5th, 2023 15:48

2013 journal article

Indole-triazole conjugates are selective inhibitors and inducers of bacterial biofilms

MEDCHEMCOMM, 4(6), 916–919.

By: M. Minvielle n, C. Bunders n & C. Melander n

TL;DR: Structural/function studies revealed that the addition of a bromine atom at the 2-position of the indole/triazole scaffold altered activity against both Gram-negative and Gram-positive bacteria and could transform a biofilm inhibitor into aBiofilm inducer. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Small Molecule Suppression of Carbapenem Resistance in NDM-1 Producing Klebsiella pneumoniae


By: R. Worthington n, C. Bunders n, C. Reed n & C. Melander n

author keywords: NDM-1; Klebsiella pneumoniae; antibiotic adjuvant; resistance suppression; 2-aminoimidazole
TL;DR: A 2-aminoimidazole derived small molecule is identified that acts as an antibiotic adjuvant and is able to suppress resistance of a NDM-1 producing strain of K. pneumoniae, able to lower carbapenem minimum inhibitory concentrations by up to 16-fold while exhibiting little bactericidal activity itself. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms


By: C. Bunders n, J. Cavanagh n & C. Melander n

MeSH headings : Amides / chemical synthesis; Amides / chemistry; Amides / pharmacology; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Biofilms / drug effects; Indole Alkaloids / chemistry; Indoles / chemical synthesis; Indoles / chemistry; Indoles / pharmacology; Inhibitory Concentration 50; Molecular Structure; Pyrroles / chemical synthesis; Pyrroles / chemistry; Pyrroles / pharmacology; Quantitative Structure-Activity Relationship; Small Molecule Libraries / chemical synthesis; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology
TL;DR: Screening for the ability to modulate biofilm formation against strains of Gram-positive and Gram-negative bacteria identified several compounds with low micromolar, non-toxic IC(50) values. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Intercepting Bacterial Indole Signaling with Flustramine Derivatives


By: C. Bunders n, M. Minvielle n, R. Worthington n, M. Ortiz n, J. Cavanagh n & C. Melander n

MeSH headings : Escherichia coli / metabolism; Hydrocarbons, Brominated / metabolism; Indole Alkaloids / metabolism; Indoles / metabolism; Signal Transduction; Staphylococcus aureus / metabolism
TL;DR: DFBr derivatives are found that are 10-1000 times more active than indole itself, demonstrating that the flustramine family of indolic natural products represent a privileged scaffold for the design of molecules to control pathogenic bacterial behavior. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Identification of aryl 2-aminoimidazoles as biofilm inhibitors in Gram-negative bacteria


By: C. Bunders n, J. Richards n & C. Melander n

author keywords: 2-Aminoimidazoles; Bacterial biofilms
MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / chemistry; Biofilms / drug effects; Escherichia coli / drug effects; Gram-Negative Bacteria / drug effects; Imidazoles / chemistry; Imidazoles / pharmacology; Plankton / drug effects; Pseudomonas aeruginosa / drug effects; Small Molecule Libraries / chemical synthesis
TL;DR: The synthesis and biofilm inhibitory activity of a 30-member aryl amide 2-aminoimidazole library against the three biofilm forming Gram-negative bacteria Escherichia coli, Psuedomonas aeruginosa, and Acinetobacter baumannii is presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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