@article{minvielle_bunders_melander_2013, title={Indole-triazole conjugates are selective inhibitors and inducers of bacterial biofilms}, volume={4}, ISSN={["2040-2511"]}, DOI={10.1039/c3md00064h}, abstractNote={Herein is described a method of accessing indole/triazole and benzothiophene/triazole analogues that selectively promote or inhibit biofilm formation by Gram-positive and Gram-negative bacteria. Structure/function studies revealed that the addition of a bromine atom at the 2-position of the indole/triazole scaffold altered activity against both Gram-negative and Gram-positive bacteria and could transform a biofilm inhibitor into a biofilm inducer. Isosteric replacement of the indole core by a benzothiophene significantly impaired anti-biofilm activity. A competition assay exposing Escherichia coli to the most potent biofilm inducer and an inhibitor of E. coli biofilm formation was performed. The inducer exhibited the ability to mute the effect of the anti-biofilm compound for this targeted bacterial population.}, number={6}, journal={MEDCHEMCOMM}, author={Minvielle, Marine J. and Bunders, Cynthia A. and Melander, Christian}, year={2013}, month={Jun}, pages={916–919} }
 @article{worthington_bunders_reed_melander_2012, title={Small Molecule Suppression of Carbapenem Resistance in NDM-1 Producing Klebsiella pneumoniae}, volume={3}, ISSN={["1948-5875"]}, DOI={10.1021/ml200290p}, abstractNote={The already considerable global public health threat of multi-drug resistant Gram-negative bacteria has become even more of a concern following the emergence of New-Delhi metallo-β-lactamase (NDM-1) producing strains of Klebsiella pneumoniae and other Gram-negative bacteria. As an alternative approach to the traditional development of new bactericidal entities, we have identified a 2-aminoimidazole derived small molecule that acts as an antibiotic adjuvant and is able to suppress resistance of a NDM-1 producing strain of K. pneumoniae to imipenem and meropenem, in addition to suppressing resistance of other β-lactam non-susceptible K. pneumoniae strains. The small molecule is able to lower carbapenem minimum inhibitory concentrations by up to 16-fold while exhibiting little bactericidal activity itself.}, number={5}, journal={ACS MEDICINAL CHEMISTRY LETTERS}, author={Worthington, Roberta J. and Bunders, Cynthia A. and Reed, Catherine S. and Melander, Christian}, year={2012}, month={May}, pages={357–361} }
 @article{bunders_cavanagh_melander_2011, title={Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms}, volume={9}, ISSN={["1477-0539"]}, DOI={10.1039/c1ob05605k}, abstractNote={Anti-biofilm agents have been developed based upon the flustramine family of alkaloids isolated from Flustra foliacea. A Garg interrupted Fischer indolization reaction was employed to access a core pyrroloindoline scaffold that was subsequently employed to create a pyrroloindoline triazole amide library. Screening for the ability to modulate biofilm formation against strains of Gram-positive and Gram-negative bacteria identified several compounds with low micromolar, non-toxic IC(50) values.}, number={15}, journal={ORGANIC & BIOMOLECULAR CHEMISTRY}, author={Bunders, Cynthia and Cavanagh, John and Melander, Christian}, year={2011}, pages={5476–5481} }
 @article{bunders_minvielle_worthington_ortiz_cavanagh_melander_2011, title={Intercepting Bacterial Indole Signaling with Flustramine Derivatives}, volume={133}, ISSN={["1520-5126"]}, DOI={10.1021/ja209836z}, abstractNote={Indole signaling is one of the putative universal signaling networks in bacteria. We have investigated the use of desformylflustrabromine (dFBr) derivatives for the inhibition of biofilm formation through modulation of the indole-signaling network in Escherichia coli and Staphylococcus aureus . We have found dFBr derivatives that are 10-1000 times more active than indole itself, demonstrating that the flustramine family of indolic natural products represent a privileged scaffold for the design of molecules to control pathogenic bacterial behavior.}, number={50}, journal={JOURNAL OF THE AMERICAN CHEMICAL SOCIETY}, author={Bunders, Cynthia A. and Minvielle, Marine J. and Worthington, Roberta J. and Ortiz, Minoshka and Cavanagh, John and Melander, Christian}, year={2011}, month={Dec}, pages={20160–20163} }
 @article{bunders_richards_melander_2010, title={Identification of aryl 2-aminoimidazoles as biofilm inhibitors in Gram-negative bacteria}, volume={20}, ISSN={["0960-894X"]}, DOI={10.1016/j.bmcl.2010.04.042}, abstractNote={The synthesis and biofilm inhibitory activity of a 30-member aryl amide 2-aminoimidazole library against the three biofilm forming Gram-negative bacteria Escherichia coli, Psuedomonas aeruginosa, and Acinetobacter baumannii is presented. The most active compound identified inhibits the formation of E. coli biofilms with an IC50 of 5.2 μM and was observed to be non-toxic to planktonic growth, demonstrating that analogues based on an aryl framework are viable options as biofilm inhibitors within the 2-aminoimidazole family.}, number={12}, journal={BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, author={Bunders, Cynthia A. and Richards, Justin J. and Melander, Christian}, year={2010}, month={Jun}, pages={3797–3800} }