Works (5)

Updated: July 13th, 2023 21:19

2023 journal article

Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain

ISCIENCE, 26(3).

By: X. Zhang n, G. Xiao n, C. Johnson n, Y. Cai n, Z. Horowitz n, C. Mennicke n, R. Coffey*, M. Haider* ...

TL;DR: Subtractive bulk ventral and dorsal forebrain deletions of Egfr uncovered significant and permanent decreases in oligodendrogenesis and myelination in the cortex and corpus callosum, and a regenerative population of gliogenic progenitors in the mouse forebrain may compensate for the missing EGFR-dependent dorsal glia in the bulk Egfr-deleted forebrain. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: June 5, 2023

2020 journal article

Sp2 regulates late neurogenic but not early expansive divisions of neural stem cells underlying population growth in the mouse cortex


By: C. Johnson n & H. Ghashghaei n

author keywords: Corticogenesis; Mitosis; MADM; Neurogenesis; Sp2; Neural stem cell
MeSH headings : Alleles; Animals; Cell Differentiation; Cell Division; Cell Lineage; Cell Proliferation; Cerebral Cortex / embryology; Female; Gene Deletion; Genetic Markers; Male; Mice; Mice, Transgenic; Mitosis; Mutation; Neural Stem Cells / cytology; Phenotype; Sp2 Transcription Factor / genetics; Sp2 Transcription Factor / physiology
TL;DR: It is found that loss of Sp2 in progenitors undergoing neurogenic divisions results in prolonged mitosis due to extension of early mitotic stages, and mechanistic differences between the early expansive and later neurogenic periods of cortical development are revealed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 20, 2020

2020 article

The people behind the papers - Caroline Johnson and Troy Ghashghaei

Johnson, C., & Ghashghaei, T. (2020, February). DEVELOPMENT, Vol. 147.

By: C. Johnson & T. Ghashghaei

MeSH headings : Animals; Brain / embryology; Cell Proliferation; Developmental Biology / history; Developmental Biology / methods; History, 21st Century; Mice; Mitosis; Sp2 Transcription Factor / physiology
TL;DR: This new paper in Development investigates the molecular control of mitosis in these two stages, using simultaneous labelling and gene knockout in clones in the developing mouse brain. (via Semantic Scholar)
Source: Web Of Science
Added: April 20, 2020

2017 journal article

Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning


By: N. Muthusamy n, X. Zhang n, C. Johnson n, P. Yadav* & H. Ghashghaei n

MeSH headings : Animals; Appetitive Behavior / physiology; Avoidance Learning / physiology; Behavior, Animal / physiology; Conditioning, Classical / physiology; Male; Mice; Neurogenesis / physiology; Neurons / physiology; Olfactory Cortex / physiology; Smell / physiology
TL;DR: It is demonstrated that chemogenetic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses to an aversive odor, revealing that developmentally defined sets of neurons may differentially participate in hedonic aspects of sensory learning. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Stomach curvature is generated by left-right asymmetric gut morphogenesis

DEVELOPMENT, 144(8), 1477–1483.

author keywords: Left-right; Asymmetry; Stomach; Gut; Morphogenesis; Pitx2; Xenopus; Mouse
MeSH headings : Animals; Body Patterning; Endoderm / embryology; Endoderm / metabolism; Epithelium / embryology; Epithelium / metabolism; Homeodomain Proteins / metabolism; Mice; Rotation; Signal Transduction; Stomach / anatomy & histology; Stomach / embryology; Transcription Factors / metabolism; Xenopus / embryology
TL;DR: It is shown that the mechanisms that drive the curvature of the stomach are intrinsic to the gut tube itself, and this findings have implications for how LR patterning manifests distinct types of morphological asymmetries in different contexts. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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