Works (10)

Updated: March 29th, 2024 05:01

2024 journal article

Mechanistic model-based characterization of size-exclusion-mixed-mode resins for removal of monoclonal antibody fragments

JOURNAL OF CHROMATOGRAPHY A, 1718.

By: S. Altern*, A. Kocot*, J. Lebarre n, C. Boi, M. Phillips, D. Roush*, S. Menegatti n, S. Cramer

UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, ORCID
Added: March 25, 2024

2023 article

Advances in high-throughput, high-capacity nonwoven membranes for chromatography in downstream processing: A review

Lavoie, J., Fan, J., Pourdeyhimi, B., Boi, C., & Carbonell, R. G. (2023, May 31). BIOTECHNOLOGY AND BIOENGINEERING, Vol. 5.

By: J. Lavoie n, J. Fan n, B. Pourdeyhimi n, C. Boi & R. Carbonell n

author keywords: downstream purification; fibrous systems; membrane adsorbers; membrane chromatography; nonwovens; product capture and polishing
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: June 19, 2023

2023 review

Development and Delivery of a Hands-On Short Course in Adeno-Associated Virus Manufacturing to Support Growing Workforce Needs in Gene Therapy

[Review of ]. HUMAN GENE THERAPY, 34(7-8), 259–272.

By: L. Overton n, C. Boi, S. Shastry n, C. Smith-Moore n, J. Balchunas n, D. Sambandan n, G. Gilleskie n

author keywords: viral vectors; AAV; gene therapy; biomanufacturing; training; short course
MeSH headings : Humans; Dependovirus / genetics; Genetic Therapy; Commerce; Genetic Vectors / genetics
TL;DR: The design of the course, the backgrounds of the nearly 80 students who have participated in the seven offerings held since March 2019, and feedback from the course participants are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: April 19, 2023

2023 journal article

Pseudo-affinity capture of <i>K. phaffii</i> host cell proteins in flow-through mode: Purification of protein therapeutics and proteomic study

SEPARATION AND PURIFICATION TECHNOLOGY, 326.

By: S. Sripada n, D. Elhanafi*, L. Collins n, T. Williams n, M. Linova*, J. Woodley*, C. Boi, S. Menegatti n

Contributors: S. Sripada n, D. Elhanafi*, L. Collins n, T. Williams n, M. Linova*, J. Woodley*, C. Boi, S. Menegatti n

author keywords: Komagataella phaffii; Chromatography; Protein purification; Monoclonal antibodies; Antibody fragment; Proteomics
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: October 23, 2023

2023 journal article

Purification of a monoclonal antibody using a novel high-capacity multimodal cation exchange nonwoven membrane

SEPARATION AND PURIFICATION TECHNOLOGY, 317.

By: J. Fan n, S. Sripada n, D. Pham*, M. Linova*, J. Woodley*, S. Menegatti n, C. Boi, R. Carbonell n

author keywords: Salt-tolerant multimodal ligand; Membrane adsorber; Membrane chromatography; Nonwoven membranes; Monoclonal antibodies (mAbs); High-risk HCPs
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: June 5, 2023

2022 article

A direct comparison between membrane adsorber and packed column chromatography performance (vol 1612, 460629, 2020)

Boi, C., Malavasi, A., Carbonell, R. G., & Gilleskie, G. (2022, March 15). JOURNAL OF CHROMATOGRAPHY A, Vol. 1666.

By: C. Boi, A. Malavasi n, R. Carbonell n & G. Gilleskie n

Sources: Web Of Science, ORCID
Added: February 21, 2022

2022 journal article

Purification of Adeno-Associated Virus (AAV) Serotype 2 from Spodoptera frugiperda (Sf9) Lysate by Chromatographic Nonwoven Membranes

MEMBRANES, 12(10).

By: J. Fan n, E. Barbieri n, S. Shastry n, S. Menegatti n, C. Boi & R. Carbonell n

author keywords: adeno-associated virus (AAV); viral vector purification; nonwovens; membrane adsorber; anion exchange; cation exchange; membrane chromatography
TL;DR: A strong anion-exchange membrane was developed by UV grafting glycidyl methacrylate on a polybutylene terephthalate nonwoven followed by functionalization with triethylamine, resulting in a quaternary amine ligand (AEX-TEA membrane) that exhibited a high AAV2 binding capacity and achieved excellent DNA clearance and a recovery of infectivity higher that that reported using ion-ex exchange resin chromatography. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: November 14, 2022

2021 journal article

Iminodiacetic Acid (IDA) Cation-Exchange Nonwoven Membranes for Efficient Capture of Antibodies and Antibody Fragments

MEMBRANES, 11(7).

By: J. Fan n, C. Boi, S. Lemma n, J. Lavoie n & R. Carbonell n

author keywords: membrane adsorbers; membrane chromatography; nonwoven membranes; cation-exchange; UV grafting; monoclonal antibodies (mAbs); single-chain variable fragment (scFv)
TL;DR: There is significant evidence that this weak cation-exchange nonwoven fabric platform might be a suitable alternative to packed resin chromatography for low-cost, higher productivity manufacturing of therapeutic mAbs and antibody fragments. (via Semantic Scholar)
Source: Web Of Science
Added: August 2, 2021

2021 journal article

Nonwoven Ion-Exchange Membranes with High Protein Binding Capacity for Bioseparations

MEMBRANES, 11(3).

By: S. Lemma n, C. Boi & R. Carbonell n

author keywords: nonwoven membrane; UV-grafting; membrane chromatography; ion-exchange membrane; protein purification; membrane adsorbers
TL;DR: The preparation and characterization of UV-grafted polybutylene terepthalate ion exchange nonwoven membranes for chromatographic purification of biomolecules indicate that these membranes have significant potential for use in downstream purifying of biology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: April 19, 2021

2020 journal article

A direct comparison between membrane adsorber and packed column chromatography performance

JOURNAL OF CHROMATOGRAPHY A, 1612.

By: C. Boi, A. Malavasi n, R. Carbonell n & G. Gilleskie n

author keywords: Chromatography; Membrane adsorber; Packed column; Binding capacity; Productivity
MeSH headings : Adsorption; Anion Exchange Resins; Chromatography, Ion Exchange / methods; Proteins / isolation & purification; Serum Albumin, Bovine / isolation & purification
TL;DR: The comparison was performed using anion exchange media with the same ligand immobilized on the adsorbing surface, namely the strong Q quaternary ammonium group, R-CH2-N+-(CH3)3, and bovine serum albumin as a model protein to confirm the better performance of membrane chromatography at high flow rates. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: March 10, 2020

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