@article{feng_wang_chen_lan_2011, title={GWAPower: A statistical power calculation software for genome-wide association studies with quantitative traits}, volume={12}, journal={BMC Genetics}, author={Feng, S. and Wang, S. C. and Chen, C. C. and Lan, L.}, year={2011} } @article{chen_barnhart_2008, title={Comparison of ICC and CCC for assessing agreement for data without and with replications}, volume={53}, ISSN={["1872-7352"]}, DOI={10.1016/j.csda.2008.09.026}, abstractNote={The intraclass correlation coefficient (ICC) has been traditionally used for assessing reliability between multiple observers for data with or without replications. Definitions of different versions of ICCs depend on the assumptions of specific ANOVA models. The parameter estimator for the ICC is usually based on the method of moments with the underlying assumed ANOVA model. This estimator is consistent only if the ANOVA model assumptions hold. Often these ANOVA assumptions are not met in practice and researchers may compute these estimates without verifying the assumptions. ICC is biased if the ANOVA assumptions are not met. We compute the expected value of the ICC estimator under a very general model to get a sense of the population parameter that the ICC estimator provides. We compare this expected value to another popular agreement index, concordance correlation coefficient (CCC), which is defined without ANOVA assumptions. The main findings are reported for data without replication and with replications for three types of ICCs defined by one-way ANOVA model, two-way ANOVA model without interaction and two-way ANOVA model with interaction. A blood pressure example is used for illustration. If the ICC is the choice of agreement index, we recommend to use ICC3 over other ICCs as its estimate is similar to the estimate of CCC regardless whether the ANOVA assumptions are met or not.}, number={2}, journal={COMPUTATIONAL STATISTICS & DATA ANALYSIS}, author={Chen, Chia-Cheng and Barnhart, Huiman X.}, year={2008}, month={Dec}, pages={554–564} } @article{chinnadurai_brown_van wettere_tuttle_fatzinger_linder_harms_2008, title={MORTALITIES ASSOCIATED WITH SEPSIS, PARASITISM, AND DISSEMINATED ROUND CELL NEOPLASIA IN YELLOW-LIPPED SEA KRAITS (LATICAUDA COLUBRINA)}, volume={39}, ISSN={["1937-2825"]}, DOI={10.1638/2008-0018.1}, abstractNote={Abstract This case series describes multiple mortalities associated with sepsis, neoplasia, and endoparasitism in yellow-lipped sea kraits (Laticauda colubrina) at an exhibit aquarium. Over a 2-yr period, the facility kept 42 L. colubrina, of which 38 died and 19 were suitable for necropsy and histopathology. The common clinical syndrome seen in these animals consisted of partial to compete anorexia, increased time spent “hauled-out” on land, intermittent regurgitation, chronic lethargy, and weight loss. Few animals died without premonitory signs. Nutritional support and treatment for presumptive parasitism and sepsis were unsuccessful. The mortality seen in this collection of sea kraits could be placed into three groups; one group of animals (n = 9) died of sepsis secondary to necrotizing enteritis or pneumonia; one group (n = 6) remained apparently healthy for over 1 yr and then died with multifocal granulomas and sepsis; and the last group (n = 3) died as a result of multicentric lymphoid neoplasia with secondary sepsis. The unifying factor in the majority of these cases is the presence of septicemia as the proximate cause of death. Based on the clinical picture, it is presumed that an immunosuppressive event, such as transport, captivity stress, or possible concurrent viral infection, resulted in a septic event and death.}, number={4}, journal={JOURNAL OF ZOO AND WILDLIFE MEDICINE}, author={Chinnadurai, Sathya K. and Brown, Danielle L. and Van Wettere, Arnaud and Tuttle, Allison D. and Fatzinger, Michael H. and Linder, Keith E. and Harms, Craig A.}, year={2008}, month={Dec}, pages={626–630} }