Works (1)
Updated: July 5th, 2023 15:39
2015 journal article
Harnessing natural product assembly lines: structure, promiscuity, and engineering
Journal of Industrial Microbiology & Biotechnology, 43(2-3), 371–387.
author keywords: Combinatorial biosynthesis; Synthetic biology; Enzyme engineering; Polyketide synthases; Non-ribosomal peptide synthases
MeSH headings : Biological Products / chemistry; Biological Products / metabolism; Biosynthetic Pathways / genetics; Metabolic Engineering; Peptides / metabolism; Polyketides / metabolism
TL;DR:
This review briefly summarizes recent structural advances related to natural product assembly lines, discusses chemical approaches to probing assembly line structures in the absence of traditional biophysical data, and surveys efforts that harness the inherent or engineered promiscuity of assembly lines for the synthesis of non-natural polyketides and non-ribosomal peptide analogues.
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Added: August 6, 2018
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