Casey C Nestor

Works (30)

Updated: November 8th, 2024 05:01

2024 journal article

Chronic inflammation decreases arcuate kisspeptin expression in male sheep.

Domestic Animal Encocrinology. https://www.sciencedirect.com/science/article/pii/S0739724024000316

Contributors: C. Nestor 

www.sciencedirect.com
Source: ORCID
Added: June 15, 2024

2024 article

Development of KISS1 knockout pigs is characterized by hypogonadotropic hypogonadism, normal growth, and reduced skatole

Ahern, D. F., Martins, K., Florez, J. M., Ross, C. E., Huisman, A., Cushman, R. A., … Lents, C. A. (2024, October 14). BIOLOGY OF REPRODUCTION.

By: D. Ahern*, K. Martins, J. Florez *, C. Ross *, A. Huisman *, R. Cushman *, S. Shuping n, C. Nestor n  ...

author keywords: kisspeptin; knockout; swine; skatole; luteinizing hormone; follicle-stimulating hormone; testosterone; development; reproduction
Source: Web Of Science
Added: November 4, 2024

2023 article

Central Regulation of Kndy Neurons During Undernutrition in Sheep

Nestor, C. (2023, November 6). JOURNAL OF ANIMAL SCIENCE, Vol. 101, pp. 230–231.

By: C. Nestor n 

TL;DR: This presentation will focus on the current understanding of how feed restriction impacts kisspeptin/neurokinin B/dynorphin (KNDy) neurons in young sheep and will give a glimpse into the next few years as it is examined how input to KNDy neurons could play a key role in regulating reproduction during undernutrition. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 18, 2023

2023 journal article

KNDy neurons as the GnRH pulse generator: Recent studies in ruminants

PEPTIDES, 164.

By: C. Nestor n , C. Merkley*, M. Lehman *, S. Hileman * & R. Goodman *

author keywords: Kisspeptin; Kiss1r; Nutrition; Proopiomelanocortin; Agouti-related peptide; Kisspeptin analogs
MeSH headings : Animals; Gonadotropin-Releasing Hormone; Arcuate Nucleus of Hypothalamus / metabolism; Dynorphins / metabolism; Neurokinin B / metabolism; Neurons / metabolism; Ruminants / metabolism; Kisspeptins / metabolism
TL;DR: Studies exploring the potential applications of manipulating signaling by kisspeptin, and the other KNDy peptides, to control reproductive function in domestic animals are reviewed and it is concluded that, although these approaches show some promise, they do not have major advantages over current practices at this time. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 9, 2023

2023 article

Role of Kndy and Arcuate Kiss1r-Containing Neurons in the Preovulatory Luteinizing Hormone Surge and Puberty Onset of Female sheep

Griesgraber, M. J., Onslow, K. M., Shuping, S., Bowdridge, E., Hardy, S., Aerts, E., … Goodman, R. (2023, November 6). JOURNAL OF ANIMAL SCIENCE, Vol. 101, pp. 235–236.

By: M. Griesgraber *, K. Onslow*, S. Shuping n, E. Bowdridge *, S. Hardy*, E. Aerts *, L. Coolen *, C. Nestor n  ...

author keywords: kisspeptin; luteinizing hormone; sheep
TL;DR: It is proposed that in ewes, KNDy neurons contribute to, but are not required for, the LH surge, and the role of ARC Kiss1r neurons in ovine puberty is assessed using a similar approach. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: December 11, 2023

2023 article

The effect of NK3-Saporin injection within the arcuate nucleus on puberty, the LH surge, and the response to Senktide in female sheep

Aerts, E. G., Griesgraber, M. J., Shuping, S. L., Bowdridge, E. C., Hardy, S. L., Goodman, R. L., … Hileman, S. M. (2023, October 31). BIOLOGY OF REPRODUCTION, Vol. 10.

By: E. Aerts, M. Griesgraber, S. Shuping n, E. Bowdridge, S. Hardy, R. Goodman *, C. Nestor n , S. Hileman *

author keywords: Puberty; KNDy; Luteinizing Hormone; sheep; female; NK3R
TL;DR: Results show that KNDy cells are necessary for timely puberty onset and for full expresson of the LH surge, and the occurrence of LH pulses in NK3-SAP treated ewes may indicate a recovery from an apulsatile state. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 31, 2023

2022 article

The impact of undernutrition on KNDy (kisspeptin/neurokinin B/dynorphin) neurons in female lambs

Harlow, K. L., Griesgraber, M. J., Seman, A. D., Shuping, S. L., Sommer, J. R., Griffith, E. H., … Nestor, C. C. (2022, May 17). JOURNAL OF NEUROENDOCRINOLOGY, Vol. 34.

By: K. Harlow n , M. Griesgraber *, A. Seman*, S. Shuping n, J. Sommer n, E. Griffith n , S. Hileman *, C. Nestor n 

author keywords: dynorphin; kisspeptin; LH; neurokinin B; undernutrition; xxxx; fx1
MeSH headings : Animals; Arcuate Nucleus of Hypothalamus / metabolism; Body Weight; Dynorphins / metabolism; Female; Gonadotropin-Releasing Hormone / metabolism; Kisspeptins / metabolism; Malnutrition / metabolism; Neurokinin B / metabolism; Neurons / metabolism; RNA, Messenger / metabolism; Sheep
TL;DR: The idea that KNDy neurons are important for regulating reproduction during undernutrition in female sheep is supported, as lower mRNA abundance for kisspeptin within K NDy neurons of FR lambs compared to controls with no significant change in mRNA for NKB or dynorphin is observed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: April 14, 2022

2021 journal article

Evidence That Agouti-Related Peptide May Directly Regulate Kisspeptin Neurons in Male Sheep

METABOLITES, 11(3).

By: C. Merkley, S. Shuping, J. Sommer & C. Nestor 

Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021

2021 journal article

Evidence that pubertal status impacts kisspeptin/neurokinin B/dynorphin neurons in the gilt(dagger)

BIOLOGY OF REPRODUCTION, 105(6), 1533–1544.

By: K. Harlow n , A. Renwick  n, S. Shuping n, J. Sommer n, C. Lents *, M. Knauer n, C. Nestor n 

author keywords: kisspeptin; NKB; dynorphin; swine; puberty
MeSH headings : Animals; Arcuate Nucleus of Hypothalamus / metabolism; Dynorphins / metabolism; Female; Kisspeptins / metabolism; Neurokinin B / metabolism; Neurons / physiology; Sexual Maturation; Sus scrofa / physiology
TL;DR: The degree to which KNDy neurons exist in the gilt is characterized for the first time, and the impact of pubertal status on kisspeptin, neurokinin B, and dynorphin in the arcuate nucleus of gilts is examined. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: April 18, 2022

2021 journal article

Kisspeptin, Neurokinin B, and Dynorphin Expression during Pubertal Development in Female Sheep

BIOLOGY-BASEL, 10(10).

By: E. Aerts *, K. Harlow n , M. Griesgraber *, E. Bowdridge *, S. Hardy*, C. Nestor n , S. Hileman *

author keywords: kisspeptin; neurokinin B; dynorphin; puberty; sheep; LH
TL;DR: It is concluded that puberty-associated increases in GnRH and LH secretion occur without significant changes in KNDy peptide expression and suggest that, while critical, KNDY neurons await inputs from other neural systems to trigger puberty onset. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 2, 2021

2020 article

Effects of genetic selection for early puberty on the hypothalamic-pituitary-ovarian axis in gilts

Harlow, K. L., Renwick, A., Shuping, S., Sommer, J., Knauer, M., & Nestor, C. (2020, November). JOURNAL OF ANIMAL SCIENCE, Vol. 98, pp. 212–212.

By: K. Harlow n , A. Renwick  n, S. Shuping n, J. Sommer n, M. Knauer n & C. Nestor n 

author keywords: puberty; gilt; neuroendocrine
TL;DR: It is concluded that gilts genetically selected for early puberty do so via changes within the hypothalamus that increase gonadotropin secretion and, in turn, stimulate ovarian growth to ultimately advance the timing of puberty onset. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: February 8, 2021

2020 journal article

Neuronal networks that regulate gonadotropin-releasing hormone/luteinizing hormone secretion during undernutrition: evidence from sheep

Domestic Animal Endocrinology, 3, 106469.

By: C. Merkley n, S. Shuping n & C. Nestor n 

author keywords: Undernutrition; GnRH; LH; KNDy; Sheep
MeSH headings : Animal Nutritional Physiological Phenomena; Animals; Gonadotropin-Releasing Hormone / physiology; Luteinizing Hormone / physiology; Malnutrition / veterinary; Reproduction / physiology; Sheep / physiology
TL;DR: This review summarizes work that has used the ovine model to examine the central mechanisms whereby undernutrition regulates GnRH/LH secretion and focuses on neurons that express kisspeptin, neurokinin B, dynorphin, proopiomelanocortin, and neuropeptide y/agouti-related peptide (NPY/AgRP). (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: March 10, 2020

2018 review

Regulation of GnRH pulsatility in ewes

[Review of ]. REPRODUCTION, 156(3), R83–R99.

By: C. Nestor n , M. Bedenbaugh *, S. Hileman *, L. Coolen *, M. Lehman * & R. Goodman *

MeSH headings : Animals; Arcuate Nucleus of Hypothalamus / physiology; Breeding; Dynorphins / physiology; Estradiol / pharmacology; Estrous Cycle; Feedback, Physiological; Female; Gonadotropin-Releasing Hormone / metabolism; Homeostasis / physiology; Kisspeptins / physiology; Luteinizing Hormone / metabolism; Neurokinin B / physiology; Neurons / physiology; Periodicity; Progesterone / pharmacology; Seasons; Sexual Maturation / physiology; Sheep / physiology
TL;DR: Current understanding of the neural systems mediating the actions of ovarian steroids and three external inputs on GnRH pulsatility is described in light of the hypothesis that KNDy neurons play a key role in GnRH pulse generation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 19, 2018

2017 journal article

AgRP to Kiss1 neuron signaling links nutritional state and fertility

Proceedings of the National Academy of Sciences, 114(9), 2413–2418.

By: S. Padilla*, J. Qiu *, C. Nestor* , C. Zhang *, A. Smith*, B. Whiddon*, O. Rønnekleiv *, M. Kelly *, R. Palmiter *

MeSH headings : Agouti-Related Protein / deficiency; Agouti-Related Protein / genetics; Animals; Circadian Clocks / drug effects; Circadian Clocks / physiology; Clozapine / analogs & derivatives; Clozapine / pharmacology; Estrous Cycle / drug effects; Estrous Cycle / physiology; Female; Fertility / drug effects; Fertility / genetics; Gene Expression Regulation; Gonadotropin-Releasing Hormone / genetics; Gonadotropin-Releasing Hormone / metabolism; Hypothalamus / drug effects; Hypothalamus / metabolism; Kisspeptins / genetics; Kisspeptins / metabolism; Leptin / genetics; Leptin / metabolism; Luteinizing Hormone / genetics; Luteinizing Hormone / metabolism; Male; Mice; Mice, Transgenic; Neurons / cytology; Neurons / drug effects; Neurons / metabolism; Optogenetics; Reproduction / drug effects; Reproduction / genetics; Signal Transduction; Starvation / genetics; Stereotaxic Techniques
TL;DR: It is found that starvation-activated agouti-related peptide (AgRP) neurons can inhibit the reproductive neuroendocrine circuit and is consistent with the idea that, during metabolic deficiency, AgRP signaling contributes to infertility by inhibiting Kiss1 neurons. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries, Crossref
Added: August 6, 2018

2017 journal article

Estradiol Protects Proopiomelanocortin Neurons Against Insulin Resistance.

Endocrinology.

Casey Nestor

MeSH headings : Animals; Calcium Channels, T-Type / genetics; Calcium Channels, T-Type / metabolism; Estradiol / pharmacology; Female; Guinea Pigs; Humans; Insulin / metabolism; Insulin Resistance; Male; Mice; Neurons / drug effects; Neurons / metabolism; Obesity / drug therapy; Obesity / genetics; Obesity / metabolism; Pro-Opiomelanocortin / metabolism; Signal Transduction / drug effects; Suppressor of Cytokine Signaling 3 Protein / genetics; Suppressor of Cytokine Signaling 3 Protein / metabolism; TRPC Cation Channels / genetics; TRPC Cation Channels / metabolism
TL;DR: E2 protects female PomC neurons from insulin resistance by enhancing POMC neuronal excitability and the coupling of insulin receptor to TRPC5 channel activation. (via Semantic Scholar)
Source: ORCID
Added: November 14, 2019

2016 journal article

Agouti-related peptide neural circuits mediate adaptive behaviors in the starved state.

Nature Neuroscience.

Casey Nestor

MeSH headings : Aggression / physiology; Agouti-Related Protein / metabolism; Agouti-Related Protein / physiology; Amygdala / metabolism; Amygdala / physiology; Animals; Fear / physiology; Gene Knock-In Techniques; Hypothalamus / metabolism; Hypothalamus / physiology; Male; Mice; Neural Pathways / metabolism; Neural Pathways / physiology; Neurons / physiology; Peptide Fragments / metabolism; Peptide Fragments / physiology; Septal Nuclei / metabolism; Septal Nuclei / physiology; Starvation / physiopathology
TL;DR: It is proposed that Hypothalamic agouti-related peptide-expressing neurons serve as a master switch capable of coordinating behavioral decisions relative to internal state and environmental cues. (via Semantic Scholar)
Source: ORCID
Added: November 14, 2019

2016 journal article

High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons

ELife, 5.

By: J. Qiu *, C. Nestor* , C. Zhang *, S. Padilla*, R. Palmiter *, M. Kelly *, O. Rønnekleiv *

MeSH headings : Action Potentials; Animals; Arcuate Nucleus of Hypothalamus / physiology; Electrophysiological Phenomena; Gonadotropin-Releasing Hormone / metabolism; Kisspeptins / metabolism; Mice; Neurokinin B / metabolism; Neurons / drug effects; Optogenetics; Real-Time Polymerase Chain Reaction
TL;DR: It is proposed that Kiss1ARH neurons play a dual role of driving episodic secretion of GnRH through the differential release of peptide and amino acid neurotransmitters to coordinate reproductive function. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 14, 2019

2016 journal article

Optogenetic Stimulation of Arcuate Nucleus Kiss1 Neurons Reveals a Steroid-Dependent Glutamatergic Input to POMC and AgRP Neurons in Male Mice

Molecular Endocrinology, 30(6), 630–644.

By: C. Nestor* , J. Qiu *, S. Padilla*, C. Zhang *, M. Bosch *, W. Fan *, R. Palmiter *, O. Rønnekleiv *, M. Kelly *, S. Aicher *

MeSH headings : Action Potentials / drug effects; Action Potentials / radiation effects; Agouti-Related Protein / metabolism; Animals; Arcuate Nucleus of Hypothalamus / drug effects; Arcuate Nucleus of Hypothalamus / metabolism; Arcuate Nucleus of Hypothalamus / radiation effects; Axons / metabolism; Axons / ultrastructure; Castration; Channelrhodopsins / metabolism; Glutamates / metabolism; Kisspeptins / metabolism; Light; Male; Mice, Inbred C57BL; Neurons / drug effects; Neurons / metabolism; Neurons / radiation effects; Optogenetics; Pro-Opiomelanocortin / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Receptors, Metabotropic Glutamate / agonists; Receptors, Metabotropic Glutamate / metabolism; Steroids / pharmacology; Up-Regulation / drug effects; Up-Regulation / radiation effects; Vesicular Glutamate Transport Protein 2 / metabolism; gamma-Aminobutyric Acid / metabolism
TL;DR: POMC and AgRP neurons receive direct steroid- and frequency-dependent glutamatergic synaptic input from Kiss1(ARC) neurons in male mice, which may be a critical pathway for Kiss1 neurons to help coordinate energy homeostasis and reproduction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 14, 2019

2014 journal article

Insulin Excites Anorexigenic Proopiomelanocortin Neurons via Activation of Canonical Transient Receptor Potential Channels

Cell Metabolism, 19(4), 682–693.

By: J. Qiu *, C. Zhang *, A. Borgquist*, C. Nestor* , A. Smith*, M. Bosch *, S. Ku*, E. Wagner *, O. Rønnekleiv *, M. Kelly *

MeSH headings : Agouti-Related Protein / metabolism; Animals; Eating / drug effects; Guinea Pigs; Insulin / pharmacology; KATP Channels / drug effects; Kisspeptins / metabolism; Mice; Models, Biological; Neurons / drug effects; Neurons / metabolism; Neuropeptide Y / metabolism; Patch-Clamp Techniques; Pro-Opiomelanocortin / metabolism; Proto-Oncogene Proteins c-fos / metabolism; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction / physiology; Transient Receptor Potential Channels / metabolism; Zinc / pharmacology
TL;DR: The results show that purified insulin excites POMC neurons in the arcuate nucleus, which is a major mechanism by which insulin regulates energy homeostasis. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 24, 2019

2014 journal article

Neurokinin-3 Receptor Activation in the Retrochiasmatic Area is Essential for the Full Pre-Ovulatory Luteinising Hormone Surge in Ewes

Journal of Neuroendocrinology, 26(11), 776–784.

By: K. Porter*, S. Hileman *, S. Hardy*, C. Nestor* , M. Lehman * & R. Goodman *

author keywords: neurokinins; GnRH; oestrogen; NK3R; LH surge
MeSH headings : Animals; Arcuate Nucleus of Hypothalamus / drug effects; Arcuate Nucleus of Hypothalamus / metabolism; Female; Hypothalamus / drug effects; Hypothalamus / metabolism; Luteinizing Hormone / blood; Neurons / drug effects; Neurons / metabolism; Ovulation / drug effects; Ovulation / metabolism; Peptide Fragments / pharmacology; Preoptic Area / drug effects; Preoptic Area / metabolism; Quinolines / pharmacology; Receptors, Neurokinin-3 / agonists; Receptors, Neurokinin-3 / antagonists & inhibitors; Receptors, Neurokinin-3 / metabolism; Sheep; Substance P / analogs & derivatives; Substance P / pharmacology
TL;DR: It is proposed that the actions of NKB in the RCh are an important component of the pre‐ovulatory LH surge in ewes. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 23, 2019

2014 journal article

Research Resource: Gene Profiling of G Protein–Coupled Receptors in the Arcuate Nucleus of the Female

Molecular Endocrinology, 28(8), 1362–1380.

By: O. Rønnekleiv *, Y. Fang *, C. Zhang *, C. Nestor* , P. Mao* & M. Kelly *

MeSH headings : Animals; Arcuate Nucleus of Hypothalamus / cytology; Arcuate Nucleus of Hypothalamus / metabolism; Cells, Cultured; Female; Gene Expression Profiling; Mice, Inbred C57BL; Neurons / metabolism; Pro-Opiomelanocortin / metabolism; Receptors, G-Protein-Coupled / genetics; Receptors, G-Protein-Coupled / metabolism; Transcriptome
TL;DR: The quantitative GPCR data emphasize the complexity of the hypothalamic arcuate nucleus and furthermore provide a valuable resource for future neuroendocrine/endocrine-related experiments. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 23, 2019

2013 journal article

Cross-talk between reproduction and energy homeostasis: central impact of estrogens, leptin and kisspeptin signaling

Hormone Molecular Biology and Clinical Investigation, 17(3).

By: C. Nestor* , M. Kelly & O. Rønnekleiv

author keywords: 17 beta-estradiol; kisspeptin; leptin; neuropeptide Y; pro-opiomelanocortin
MeSH headings : Animals; Energy Metabolism; Estradiol / metabolism; Estrogens / metabolism; Homeostasis; Humans; Kisspeptins / metabolism; Leptin / metabolism; Neurons / metabolism; Neuropeptide Y / metabolism; Phosphorylation; Pro-Opiomelanocortin / metabolism; Reproduction; STAT3 Transcription Factor / metabolism; Signal Transduction
TL;DR: Progress made in understanding the interactions between reproduction and energy homeostasis is reviewed by focusing on the advances made to understand the cellular signaling of E2 and leptin on three neural networks: kisspeptin, pro-opiomelanocortin (POMC) and neuropeptide Y (NPY). (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 23, 2019

2013 journal article

Evidence that Orphanin FQ Mediates Progesterone Negative Feedback in the Ewe

Endocrinology, 154(11), 4249–4258.

By: C. Nestor* , L. Coolen *, G. Nesselrod*, M. Valent*, J. Connors*, S. Hileman *, G. Cheng*, M. Lehman *, R. Goodman *

MeSH headings : Animals; Arcuate Nucleus of Hypothalamus / cytology; Arcuate Nucleus of Hypothalamus / metabolism; Estradiol / administration & dosage; Estradiol / pharmacology; Estrogen Receptor alpha / genetics; Estrogen Receptor alpha / metabolism; Estrus; Feedback, Physiological; Female; Hypothalamus / metabolism; Luteinizing Hormone / genetics; Luteinizing Hormone / metabolism; Neurons / metabolism; Opioid Peptides / administration & dosage; Opioid Peptides / genetics; Opioid Peptides / metabolism; Opioid Peptides / pharmacology; Ovariectomy; Progesterone / administration & dosage; Progesterone / metabolism; Progesterone / pharmacology; Protein Transport; Receptors, Progesterone / metabolism; Sheep / physiology
TL;DR: It is concluded that OFQ mediates, at least in part, the negative feedback action of P on GnRH/LH pulse frequency in sheep. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 24, 2019

2013 journal article

Kisspeptin, Neurokinin B, and Dynorphin Act in the Arcuate Nucleus to Control Activity of the GnRH Pulse Generator in Ewes

Endocrinology, 154(11), 4259–4269.

By: R. Goodman *, S. Hileman *, C. Nestor* , K. Porter*, J. Connors*, S. Hardy*, R. Millar *, M. Cernea* ...

MeSH headings : Animals; Arcuate Nucleus of Hypothalamus / cytology; Arcuate Nucleus of Hypothalamus / physiology; Dynorphins / genetics; Dynorphins / metabolism; Female; Gonadotropin-Releasing Hormone / genetics; Gonadotropin-Releasing Hormone / metabolism; Kisspeptins / genetics; Kisspeptins / metabolism; N-Methylaspartate / genetics; N-Methylaspartate / metabolism; Neurokinin B / genetics; Neurokinin B / metabolism; Neurons / classification; Neurons / metabolism; Receptors, Neurokinin-3 / genetics; Receptors, Neurokinin-3 / metabolism; Receptors, Opioid, kappa / genetics; Receptors, Opioid, kappa / metabolism; Sheep / physiology
TL;DR: It is concluded that the KNDy neuropeptides act in the arcuate nucleus to control episodic GnRH secretion in the ewe, but afferent input from GnRH neurons to this area does not, which raises the possibility that kisspeptin contributes to the control of GnRH pulse frequency. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 24, 2019

2012 journal article

Evidence That Dopamine Acts via Kisspeptin to Hold GnRH Pulse Frequency in Check in Anestrous Ewes

Endocrinology, 153(12), 5918–5927.

By: R. Goodman, M. Maltby*, R. Millar *, S. Hileman, C. Nestor* , B. Whited, A. Tseng, L. Coolen *, M. Lehman *

MeSH headings : Anestrus / drug effects; Animals; Dopamine / metabolism; Female; Gonadotropin-Releasing Hormone / metabolism; Immunohistochemistry / methods; Kisspeptins / metabolism; Luteinizing Hormone / metabolism; Models, Biological; Neurons / metabolism; Receptors, Dopamine D2 / metabolism; Seasons; Sheep
TL;DR: The hypothesis that DA acts to inhibit GnRH (and LH) secretion in anestrus by suppressing the activity of ARC kisspeptin neurons is supported. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 24, 2019

2012 journal article

Evidence of a Role for Kisspeptin and Neurokinin B in Puberty of Female Sheep

Endocrinology, 153(6), 2756–2765.

By: C. Nestor* , A. Briscoe*, S. Davis*, M. Valent*, R. Goodman * & S. Hileman *

MeSH headings : Animals; Arcuate Nucleus of Hypothalamus / cytology; Arcuate Nucleus of Hypothalamus / drug effects; Arcuate Nucleus of Hypothalamus / metabolism; Female; Gonadotropin-Releasing Hormone / antagonists & inhibitors; Gonadotropin-Releasing Hormone / metabolism; Immunohistochemistry; Kisspeptins / metabolism; Kisspeptins / physiology; Luteinizing Hormone / metabolism; Male; Neurokinin B / metabolism; Neurokinin B / physiology; Neurons / drug effects; Neurons / metabolism; Oligopeptides / pharmacology; Orchiectomy; Ovariectomy; Peptide Fragments / pharmacology; Receptors, Neurokinin-3 / antagonists & inhibitors; Receptors, Neurokinin-3 / metabolism; Sexual Maturation / physiology; Sheep / metabolism; Sheep / physiology; Substance P / analogs & derivatives; Substance P / pharmacology; Time Factors
TL;DR: The hypothesis that kisspeptin is a gatekeeper to female ovine puberty is supported and the possibility that NKB may also play a role, albeit through different means, is raised. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 24, 2019

2011 journal article

Evidence that the Arcuate Nucleus Is an Important Site of Progesterone Negative Feedback in the Ewe

Endocrinology, 152(9), 3451–3460.

By: R. Goodman, I. Holaskova, C. Nestor* , J. Connors, H. Billings, M. Valent, M. Lehman *, S. Hileman

MeSH headings : Animals; Arcuate Nucleus of Hypothalamus / drug effects; Arcuate Nucleus of Hypothalamus / physiology; Feedback, Physiological / drug effects; Feedback, Physiological / physiology; Female; Hormone Antagonists / pharmacology; Luteinizing Hormone / blood; Mifepristone / pharmacology; Neurons / drug effects; Neurons / physiology; Ovariectomy; Progesterone / physiology; Receptors, Progesterone / physiology; Sheep
TL;DR: It is concluded that the arcuate nucleus of the ARC is one important site of progesterone-negative feedback in the ewe, which is consistent with the hypothesis that ARC dynorphin neurons mediate this action of progestersone. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 24, 2019

2010 journal article

Inactivation of L-type calcium channel modulated by HCN2 channel

American Journal of Physiology-Cell Physiology, 298(5), C1029–C1037.

By: Y. Lin, J. Huang, Q. Zhang, J. Hollander *, J. Frisbee, K. Martin *, C. Nestor* , R. Goodman, H. Yu

author keywords: L-type calcium channel inactivation; hyperpolarization-activated cyclic nucleotide-gated channels; calmodulin; hippocampal neuron
MeSH headings : Animals; Calcium / metabolism; Calcium Channels, L-Type / genetics; Calcium Channels, L-Type / metabolism; Cell Line; Gene Expression Regulation / physiology; Hippocampus / metabolism; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ion Channel Gating / physiology; Ion Channels / genetics; Ion Channels / metabolism; Potassium Channels; Protein Subunits; Rats; Signal Transduction
TL;DR: Evidence is shown that a hyperpolarization-activated cyclic nucleotide-gated channel, HCN2, can act as a nonchannel regulatory protein to narrow the L-type Ca(2+) channel current-voltage curve and reveal a potentially novel protection mechanism for achieving the LTCC inactivation via interaction withHCN2. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 24, 2019

2010 journal article

Neurokinin B Acts via the Neurokinin-3 Receptor in the Retrochiasmatic Area to Stimulate Luteinizing Hormone Secretion in Sheep

Endocrinology, 151(8), 3836–3846.

By: H. Billings, J. Connors*, S. Altman*, S. Hileman *, I. Holaskova*, M. Lehman *, C. McManus*, C. Nestor*  ...

MeSH headings : Anestrus / blood; Anestrus / drug effects; Animals; Brain / drug effects; Brain / metabolism; Dopamine / metabolism; Female; Follicular Phase / drug effects; Follicular Phase / metabolism; Follicular Phase / physiology; Gonadotropin-Releasing Hormone / blood; Gonadotropin-Releasing Hormone / metabolism; Injections, Intraventricular; Luteal Phase / drug effects; Luteal Phase / metabolism; Luteal Phase / physiology; Luteinizing Hormone / blood; Luteinizing Hormone / metabolism; Models, Biological; Neurokinin B / pharmacology; Neurokinin B / physiology; Neurons / drug effects; Neurons / metabolism; Neurotransmitter Agents / pharmacology; Peptide Fragments / administration & dosage; Peptide Fragments / pharmacology; Receptors, Neurokinin-3 / agonists; Receptors, Neurokinin-3 / metabolism; Receptors, Neurokinin-3 / physiology; Sheep; Substance P / administration & dosage; Substance P / analogs & derivatives; Substance P / pharmacology
TL;DR: Evidence is provided that NKB stimulates LH (and presumably GnRH) secretion in ewes and point to the RCh as one important site of action in the control of GnRH and LH secretion in nonrodent species. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 24, 2019

2008 journal article

Evidence that γ-Aminobutyric Acid Is Part of the Neural Circuit Mediating Estradiol Negative Feedback in Anestrous Ewes

Endocrinology, 149(6), 2762–2772.

By: A. Bogusz*, S. Hardy*, M. Lehman *, J. Connors*, S. Hileman *, J. Sliwowska *, H. Billings*, C. McManus* ...

MeSH headings : Anestrus / drug effects; Anestrus / physiology; Animals; Baclofen / analogs & derivatives; Baclofen / pharmacology; Bicuculline / analogs & derivatives; Bicuculline / pharmacology; Dopamine / physiology; Estradiol / physiology; Feedback; Female; Muscimol / pharmacology; Neurons / drug effects; Neurons / physiology; Ovariectomy; Sheep; gamma-Aminobutyric Acid / physiology
TL;DR: E2 inhibits release of GABA from afferents to A15 DA neurons, increasing the activity of these DA neurons and thus suppressing episodic secretion of GnRH and LH, consistent with the hypothesis that endogenous GABA release within the A15 is low in ovary-intact anestrous ewes and elevated after ovariectomy. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 24, 2019

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