@article{duchalais_guilluy_nedellec_touvron_bessard_touchefeu_bossard_boudin_louarn_neunlist_et al._2018, title={Colorectal Cancer Cells Adhere to and Migrate Along the Neurons of the Enteric Nervous System}, volume={5}, ISSN={2352-345X}, url={http://dx.doi.org/10.1016/J.JCMGH.2017.10.002}, DOI={10.1016/J.JCMGH.2017.10.002}, number={1}, journal={Cellular and Molecular Gastroenterology and Hepatology}, publisher={Elsevier BV}, author={Duchalais, Emilie and Guilluy, Christophe and Nedellec, Steven and Touvron, Melissa and Bessard, Anne and Touchefeu, Yann and Bossard, Céline and Boudin, Hélène and Louarn, Guy and Neunlist, Michel and et al.}, year={2018}, pages={31–49} } @article{marchand_umana_pichol-thievend_salza_ricard-blum_monnot_guilluy_muller_germain_2017, title={Lysyl oxidase like-2 (LOXL2) regulates endothelial mechanotransduction and 3D vascular morphogenesis through scaffolding of basement membrane}, volume={9}, ISSN={1878-6480}, url={http://dx.doi.org/10.1016/S1878-6480(17)30407-X}, DOI={10.1016/S1878-6480(17)30407-X}, number={2}, journal={Archives of Cardiovascular Diseases Supplements}, publisher={Elsevier BV}, author={Marchand, M. and Umana, C. and Pichol-Thievend, C. and Salza, R. and Ricard-Blum, S. and Monnot, C. and Guilluy, C. and Muller, L. and Germain, S.}, year={2017}, month={Apr}, pages={164} } @article{aureille_belaadi_guilluy_2017, title={Mechanotransduction via the nuclear envelope: a distant reflection of the cell surface}, volume={44}, ISSN={0955-0674}, url={http://dx.doi.org/10.1016/J.CEB.2016.10.003}, DOI={10.1016/J.CEB.2016.10.003}, journal={Current Opinion in Cell Biology}, publisher={Elsevier BV}, author={Aureille, Julien and Belaadi, Néjma and Guilluy, Christophe}, year={2017}, month={Feb}, pages={59–67} } @article{burridge_guilluy_2016, title={Focal adhesions, stress fibers and mechanical tension}, volume={343}, ISSN={0014-4827}, url={http://dx.doi.org/10.1016/J.YEXCR.2015.10.029}, DOI={10.1016/J.YEXCR.2015.10.029}, number={1}, journal={Experimental Cell Research}, publisher={Elsevier BV}, author={Burridge, Keith and Guilluy, Christophe}, year={2016}, month={Apr}, pages={14–20} } @article{marjoram_guilluy_burridge_2016, title={Using magnets and magnetic beads to dissect signaling pathways activated by mechanical tension applied to cells}, volume={94}, ISSN={1046-2023}, url={http://dx.doi.org/10.1016/J.YMETH.2015.09.025}, DOI={10.1016/J.YMETH.2015.09.025}, journal={Methods}, publisher={Elsevier BV}, author={Marjoram, R.J. and Guilluy, C. and Burridge, K.}, year={2016}, month={Feb}, pages={19–26} } @article{guilluy_burridge_2015, title={Nuclear mechanotransduction: Forcing the nucleus to respond}, volume={6}, ISSN={1949-1034 1949-1042}, url={http://dx.doi.org/10.1080/19491034.2014.1001705}, DOI={10.1080/19491034.2014.1001705}, number={1}, journal={Nucleus}, publisher={Informa UK Limited}, author={Guilluy, Christophe and Burridge, Keith}, year={2015}, month={Jan}, pages={19–22} } @article{collins_osborne_guilluy_chen_o’brien_reader_burridge_superfine_tzima_2014, title={Haemodynamic and extracellular matrix cues regulate the mechanical phenotype and stiffness of aortic endothelial cells}, volume={5}, ISSN={2041-1723}, url={http://dx.doi.org/10.1038/NCOMMS4984}, DOI={10.1038/NCOMMS4984}, number={1}, journal={Nature Communications}, publisher={Springer Science and Business Media LLC}, author={Collins, Caitlin and Osborne, Lukas D. and Guilluy, Christophe and Chen, Zhongming and O’Brien, E. Tim, III and Reader, John S. and Burridge, Keith and Superfine, Richard and Tzima, Ellie}, year={2014}, month={Jun} } @article{guilluy_osborne_van landeghem_sharek_superfine_garcia-mata_burridge_2014, title={Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus}, volume={16}, ISSN={1465-7392 1476-4679}, url={http://dx.doi.org/10.1038/NCB2927}, DOI={10.1038/NCB2927}, number={4}, journal={Nature Cell Biology}, publisher={Springer Science and Business Media LLC}, author={Guilluy, Christophe and Osborne, Lukas D. and Van Landeghem, Laurianne and Sharek, Lisa and Superfine, Richard and Garcia-Mata, Rafael and Burridge, Keith}, year={2014}, month={Mar}, pages={376–381} } @article{bays_peng_tolbert_guilluy_angell_pan_superfine_burridge_demali_2014, title={Vinculin phosphorylation differentially regulates mechanotransduction at cell–cell and cell–matrix adhesions}, volume={205}, ISSN={1540-8140 0021-9525}, url={http://dx.doi.org/10.1083/JCB.201309092}, DOI={10.1083/JCB.201309092}, abstractNote={Cells experience mechanical forces throughout their lifetimes. Vinculin is critical for transmitting these forces, yet how it achieves its distinct functions at cell–cell and cell–matrix adhesions remains unanswered. Here, we show vinculin is phosphorylated at Y822 in cell–cell, but not cell–matrix, adhesions. Phosphorylation at Y822 was elevated when forces were applied to E-cadherin and was required for vinculin to integrate into the cadherin complex. The mutation Y822F ablated these activities and prevented cells from stiffening in response to forces on E-cadherin. In contrast, Y822 phosphorylation was not required for vinculin functions in cell–matrix adhesions, including integrin-induced cell stiffening. Finally, forces applied to E-cadherin activated Abelson (Abl) tyrosine kinase to phosphorylate vinculin; Abl inhibition mimicked the loss of vinculin phosphorylation. These data reveal an unexpected regulatory mechanism in which vinculin Y822 phosphorylation determines whether cadherins transmit force and provides a paradigm for how a shared component of adhesions can produce biologically distinct functions.}, number={2}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Bays, Jennifer L. and Peng, Xiao and Tolbert, Catlin E. and Guilluy, Christophe and Angell, Ashley E. and Pan, Yuan and Superfine, Richard and Burridge, Keith and DeMali, Kris A.}, year={2014}, month={Apr}, pages={251–263} } @article{thompson_guilluy_xie_sen_brobst_yen_uzer_styner_case_burridge_et al._2013, title={Mechanically activated fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells}, volume={31}, ISSN={1066-5099}, url={http://dx.doi.org/10.1002/STEM.1476}, DOI={10.1002/STEM.1476}, number={11}, journal={STEM CELLS}, publisher={Wiley}, author={Thompson, William R. and Guilluy, Christophe and Xie, Zhihui and Sen, Buer and Brobst, Kaitlyn E. and Yen, Sherwin S. and Uzer, Gunes and Styner, Maya and Case, Natasha and Burridge, Keith and et al.}, year={2013}, month={Nov}, pages={2528–2537} } @article{lessey_guilluy_burridge_2012, title={From Mechanical Force to RhoA Activation}, volume={51}, ISSN={0006-2960 1520-4995}, url={http://dx.doi.org/10.1021/bi300758e}, DOI={10.1021/bi300758e}, number={38}, journal={Biochemistry}, publisher={American Chemical Society (ACS)}, author={Lessey, Elizabeth C. and Guilluy, Christophe and Burridge, Keith}, year={2012}, month={Sep}, pages={7420–7432} } @article{collins_guilluy_welch_o’brien_hahn_superfine_burridge_tzima_2012, title={Localized Tensional Forces on PECAM-1 Elicit a Global Mechanotransduction Response via the Integrin-RhoA Pathway}, volume={22}, ISSN={0960-9822}, url={http://dx.doi.org/10.1016/j.cub.2012.08.051}, DOI={10.1016/j.cub.2012.08.051}, number={22}, journal={Current Biology}, publisher={Elsevier BV}, author={Collins, Caitlin and Guilluy, Christophe and Welch, Christopher and O’Brien, E. Timothy and Hahn, Klaus and Superfine, Richard and Burridge, Keith and Tzima, Ellie}, year={2012}, month={Nov}, pages={2087–2094} } @article{guilluy_dubash_garcía-mata_2011, title={Analysis of RhoA and Rho GEF activity in whole cells and the cell nucleus}, volume={6}, ISSN={1754-2189 1750-2799}, url={http://dx.doi.org/10.1038/nprot.2011.411}, DOI={10.1038/nprot.2011.411}, number={12}, journal={Nature Protocols}, publisher={Springer Science and Business Media LLC}, author={Guilluy, Christophe and Dubash, Adi D and García-Mata, Rafael}, year={2011}, month={Dec}, pages={2050–2060} } @article{sen_guilluy_xie_case_styner_thomas_oguz_rubin_burridge_rubin_2011, title={Mechanically Induced Focal Adhesion Assembly Amplifies Anti-Adipogenic Pathways in Mesenchymal Stem Cells}, volume={29}, ISSN={1066-5099}, url={http://dx.doi.org/10.1002/stem.732}, DOI={10.1002/stem.732}, number={11}, journal={STEM CELLS}, publisher={Wiley}, author={Sen, Buer and Guilluy, Christophe and Xie, Zhihui and Case, Natasha and Styner, Maya and Thomas, Jacob and Oguz, Ipek and Rubin, Clinton and Burridge, Keith and Rubin, Janet}, year={2011}, month={Oct}, pages={1829–1836} } @article{guilluy_garcia-mata_burridge_2011, title={Rho protein crosstalk: another social network?}, volume={21}, ISSN={0962-8924}, url={http://dx.doi.org/10.1016/j.tcb.2011.08.002}, DOI={10.1016/j.tcb.2011.08.002}, number={12}, journal={Trends in Cell Biology}, publisher={Elsevier BV}, author={Guilluy, Christophe and Garcia-Mata, Rafael and Burridge, Keith}, year={2011}, month={Dec}, pages={718–726} } @article{guilluy_swaminathan_garcia-mata_timothy o’brien_superfine_burridge_2011, title={The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins}, volume={13}, ISSN={1465-7392 1476-4679}, url={http://dx.doi.org/10.1038/ncb2254}, DOI={10.1038/ncb2254}, number={6}, journal={Nature Cell Biology}, publisher={Springer Science and Business Media LLC}, author={Guilluy, Christophe and Swaminathan, Vinay and Garcia-Mata, Rafael and Timothy O’Brien, E. and Superfine, Richard and Burridge, Keith}, year={2011}, month={May}, pages={722–727} } @article{shen_tolbert_guilluy_swaminathan_berginski_burridge_superfine_campbell_2011, title={The Vinculin C-terminal Hairpin Mediates F-actin Bundle Formation, Focal Adhesion, and Cell Mechanical Properties}, volume={286}, ISSN={0021-9258 1083-351X}, url={http://dx.doi.org/10.1074/jbc.M111.244293}, DOI={10.1074/jbc.M111.244293}, number={52}, journal={Journal of Biological Chemistry}, publisher={American Society for Biochemistry & Molecular Biology (ASBMB)}, author={Shen, Kai and Tolbert, Caitlin E. and Guilluy, Christophe and Swaminathan, Vinay S. and Berginski, Matthew E. and Burridge, Keith and Superfine, Richard and Campbell, Sharon L.}, year={2011}, month={Nov}, pages={45103–45115} } @article{boulter_garcia-mata_guilluy_dubash_rossi_brennwald_burridge_2010, title={Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1}, volume={12}, ISSN={1465-7392 1476-4679}, url={http://dx.doi.org/10.1038/ncb2049}, DOI={10.1038/ncb2049}, number={5}, journal={Nature Cell Biology}, publisher={Springer Science and Business Media LLC}, author={Boulter, Etienne and Garcia-Mata, Rafael and Guilluy, Christophe and Dubash, Adi and Rossi, Guendalina and Brennwald, Patrick J. and Burridge, Keith}, year={2010}, month={Apr}, pages={477–483} } @article{guilluy_brégeon_toumaniantz_rolli-derkinderen_retailleau_loufrani_henrion_scalbert_bril_torres_et al._2010, title={The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure}, volume={16}, ISSN={1078-8956 1546-170X}, url={http://dx.doi.org/10.1038/nm.2079}, DOI={10.1038/nm.2079}, number={2}, journal={Nature Medicine}, publisher={Springer Science and Business Media LLC}, author={Guilluy, Christophe and Brégeon, Jérémy and Toumaniantz, Gilles and Rolli-Derkinderen, Malvyne and Retailleau, Kevin and Loufrani, Laurent and Henrion, Daniel and Scalbert, Elizabeth and Bril, Antoine and Torres, Raul M and et al.}, year={2010}, month={Jan}, pages={183–190} } @article{agard_guilluy_eddahibi_guignabert_izikki_tu_savale_humbert_fadel_adnot_et al._2009, title={Activation de Rho kinase par sérotonylation intracellulaire de la petite protéine G RhoA dans l’hypertension artérielle pulmonaire}, volume={30}, ISSN={0248-8663}, url={http://dx.doi.org/10.1016/j.revmed.2009.10.132}, DOI={10.1016/j.revmed.2009.10.132}, journal={La Revue de Médecine Interne}, publisher={Elsevier BV}, author={Agard, C. and Guilluy, C. and Eddahibi, S. and Guignabert, C. and Izikki, M. and Tu, L. and Savale, L. and Humbert, M. and Fadel, E. and Adnot, S. and et al.}, year={2009}, month={Dec}, pages={S373} } @article{bregeon_guilluy_toumaniantz_rolliderkinderen_retailleau_loufrani_henrion_scalbert_bril_pacaud_et al._2009, title={I025 Smooth muscle specific deletion of the RhoA exchange factor Arhgef1 protects against Ang II-dependent hypertension}, volume={102}, ISSN={1875-2136}, url={http://dx.doi.org/10.1016/S1875-2136(09)72359-9}, DOI={10.1016/S1875-2136(09)72359-9}, journal={Archives of Cardiovascular Diseases}, publisher={Elsevier BV}, author={Bregeon, J. and Guilluy, C. and Toumaniantz, G. and Rolliderkinderen, M. and Retailleau, K. and Loufrani, L. and Henrion, D. and Scalbert, E. and Bril, A. and Pacaud, P. and et al.}, year={2009}, month={Mar}, pages={S95–S96} } @article{goueffic_guilluy_guerin_patra_pacaud_loirand_2006, title={Hyaluronan induces vascular smooth muscle cell migration through RHAMM-mediated PI3K-dependent Rac activation}, volume={72}, ISSN={0008-6363}, url={http://dx.doi.org/10.1016/J.CARDIORES.2006.07.017}, DOI={10.1016/J.CARDIORES.2006.07.017}, number={2}, journal={Cardiovascular Research}, publisher={Oxford University Press (OUP)}, author={Goueffic, Y and Guilluy, C and Guerin, P and Patra, P and Pacaud, P and Loirand, G}, year={2006}, month={Nov}, pages={339–348} } @article{loirand_guilluy_pacaud_2006, title={Regulation of Rho Proteins by Phosphorylation in the Cardiovascular System}, volume={16}, ISSN={1050-1738}, url={http://dx.doi.org/10.1016/j.tcm.2006.03.010}, DOI={10.1016/j.tcm.2006.03.010}, number={6}, journal={Trends in Cardiovascular Medicine}, publisher={Elsevier BV}, author={Loirand, Gervaise and Guilluy, Christophe and Pacaud, Pierre}, year={2006}, month={Aug}, pages={199–204} } @article{guilluy_rolli-derkinderen_tharaux_melino_pacaud_loirand_2006, title={Transglutaminase-dependent RhoA Activation and Depletion by Serotonin in Vascular Smooth Muscle Cells}, volume={282}, ISSN={0021-9258 1083-351X}, url={http://dx.doi.org/10.1074/jbc.M604195200}, DOI={10.1074/jbc.M604195200}, number={5}, journal={Journal of Biological Chemistry}, publisher={American Society for Biochemistry & Molecular Biology (ASBMB)}, author={Guilluy, Christophe and Rolli-Derkinderen, Malvyne and Tharaux, Pierre-Louis and Melino, Gerry and Pacaud, Pierre and Loirand, Gervaise}, year={2006}, month={Dec}, pages={2918–2928} } @article{guilluy_sauzeau_rolli-derkinderen_guérin_sagan_pacaud_loirand_2005, title={Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension}, volume={146}, ISSN={0007-1188 1476-5381}, url={http://dx.doi.org/10.1038/SJ.BJP.0706408}, DOI={10.1038/SJ.BJP.0706408}, number={7}, journal={British Journal of Pharmacology}, publisher={Wiley}, author={Guilluy, Christophe and Sauzeau, Vincent and Rolli-Derkinderen, Malvyne and Guérin, Patrice and Sagan, Christine and Pacaud, Pierre and Loirand, Gervaise}, year={2005}, month={Dec}, pages={1010–1018} }