Christophe Guilluy

Buglak, D. B., Bougaran, P., Kulikauskas, M. R., Liu, Z., Monaghan-Benson, E., Gold, A. L., … Bautch, V. L. (2023). Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation. ELIFE, 12. https://doi.org/10.7554/eLife.83652

Belaadi, N., Pernet, L., Aureille, J., Chadeuf, G., Rio, M., Vaillant, N., … Guilluy, C. (2022). SUN2 regulates mitotic duration in response to extracellular matrix rigidity. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(45). https://doi.org/10.1073/pnas.2116167119

Duchalais, E., Guilluy, C., Nedellec, S., Touvron, M., Bessard, A., Touchefeu, Y., … Van Landeghem, L. (2018). Colorectal Cancer Cells Adhere to and Migrate Along the Neurons of the Enteric Nervous System. Cellular and Molecular Gastroenterology and Hepatology, 5(1), 31–49. https://doi.org/10.1016/J.JCMGH.2017.10.002

Marchand, M., Umana, C., Pichol-Thievend, C., Salza, R., Ricard-Blum, S., Monnot, C., … Germain, S. (2017). Lysyl oxidase like-2 (LOXL2) regulates endothelial mechanotransduction and 3D vascular morphogenesis through scaffolding of basement membrane. Archives of Cardiovascular Diseases Supplements, 9(2), 164. https://doi.org/10.1016/S1878-6480(17)30407-X

Aureille, J., Belaadi, N., & Guilluy, C. (2017). Mechanotransduction via the nuclear envelope: a distant reflection of the cell surface. Current Opinion in Cell Biology, 44, 59–67. https://doi.org/10.1016/J.CEB.2016.10.003

Burridge, K., & Guilluy, C. (2016). Focal adhesions, stress fibers and mechanical tension. Experimental Cell Research, 343(1), 14–20. https://doi.org/10.1016/J.YEXCR.2015.10.029

Marjoram, R. J., Guilluy, C., & Burridge, K. (2016). Using magnets and magnetic beads to dissect signaling pathways activated by mechanical tension applied to cells. Methods, 94, 19–26. https://doi.org/10.1016/J.YMETH.2015.09.025

Guilluy, C., & Burridge, K. (2015). Nuclear mechanotransduction: Forcing the nucleus to respond. Nucleus, 6(1), 19–22. https://doi.org/10.1080/19491034.2014.1001705

Collins, C., Osborne, L. D., Guilluy, C., Chen, Z., O’Brien, E. T., III, Reader, J. S., … Tzima, E. (2014). Haemodynamic and extracellular matrix cues regulate the mechanical phenotype and stiffness of aortic endothelial cells. Nature Communications, 5(1). https://doi.org/10.1038/NCOMMS4984

Guilluy, C., Osborne, L. D., Van Landeghem, L., Sharek, L., Superfine, R., Garcia-Mata, R., & Burridge, K. (2014). Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus. Nature Cell Biology, 16(4), 376–381. https://doi.org/10.1038/NCB2927

Bays, J. L., Peng, X., Tolbert, C. E., Guilluy, C., Angell, A. E., Pan, Y., … DeMali, K. A. (2014). Vinculin phosphorylation differentially regulates mechanotransduction at cell–cell and cell–matrix adhesions. The Journal of Cell Biology, 205(2), 251–263. https://doi.org/10.1083/JCB.201309092

Thompson, W. R., Guilluy, C., Xie, Z., Sen, B., Brobst, K. E., Yen, S. S., … Rubin, J. (2013). Mechanically activated fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells. STEM CELLS, 31(11), 2528–2537. https://doi.org/10.1002/STEM.1476

Lessey, E. C., Guilluy, C., & Burridge, K. (2012). From Mechanical Force to RhoA Activation. Biochemistry, 51(38), 7420–7432. https://doi.org/10.1021/bi300758e

Collins, C., Guilluy, C., Welch, C., O’Brien, E. T., Hahn, K., Superfine, R., … Tzima, E. (2012). Localized Tensional Forces on PECAM-1 Elicit a Global Mechanotransduction Response via the Integrin-RhoA Pathway. Current Biology, 22(22), 2087–2094. https://doi.org/10.1016/j.cub.2012.08.051

Guilluy, C., Dubash, A. D., & García-Mata, R. (2011). Analysis of RhoA and Rho GEF activity in whole cells and the cell nucleus. Nature Protocols, 6(12), 2050–2060. https://doi.org/10.1038/nprot.2011.411

Sen, B., Guilluy, C., Xie, Z., Case, N., Styner, M., Thomas, J., … Rubin, J. (2011). Mechanically Induced Focal Adhesion Assembly Amplifies Anti-Adipogenic Pathways in Mesenchymal Stem Cells. STEM CELLS, 29(11), 1829–1836. https://doi.org/10.1002/stem.732

Guilluy, C., Garcia-Mata, R., & Burridge, K. (2011). Rho protein crosstalk: another social network? Trends in Cell Biology, 21(12), 718–726. https://doi.org/10.1016/j.tcb.2011.08.002

Guilluy, C., Swaminathan, V., Garcia-Mata, R., Timothy O’Brien, E., Superfine, R., & Burridge, K. (2011). The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins. Nature Cell Biology, 13(6), 722–727. https://doi.org/10.1038/ncb2254

Shen, K., Tolbert, C. E., Guilluy, C., Swaminathan, V. S., Berginski, M. E., Burridge, K., … Campbell, S. L. (2011). The Vinculin C-terminal Hairpin Mediates F-actin Bundle Formation, Focal Adhesion, and Cell Mechanical Properties. Journal of Biological Chemistry, 286(52), 45103–45115. https://doi.org/10.1074/jbc.M111.244293

Boulter, E., Garcia-Mata, R., Guilluy, C., Dubash, A., Rossi, G., Brennwald, P. J., & Burridge, K. (2010). Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1. Nature Cell Biology, 12(5), 477–483. https://doi.org/10.1038/ncb2049

Guilluy, C., Brégeon, J., Toumaniantz, G., Rolli-Derkinderen, M., Retailleau, K., Loufrani, L., … Loirand, G. (2010). The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure. Nature Medicine, 16(2), 183–190. https://doi.org/10.1038/nm.2079

Agard, C., Guilluy, C., Eddahibi, S., Guignabert, C., Izikki, M., Tu, L., … Pacaud, P. (2009). Activation de Rho kinase par sérotonylation intracellulaire de la petite protéine G RhoA dans l’hypertension artérielle pulmonaire. La Revue De Médecine Interne, 30, S373. https://doi.org/10.1016/j.revmed.2009.10.132

Bregeon, J., Guilluy, C., Toumaniantz, G., Rolliderkinderen, M., Retailleau, K., Loufrani, L., … Loirand, G. (2009). I025 Smooth muscle specific deletion of the RhoA exchange factor Arhgef1 protects against Ang II-dependent hypertension. Archives of Cardiovascular Diseases, 102, S95–S96. https://doi.org/10.1016/S1875-2136(09)72359-9

Goueffic, Y., Guilluy, C., Guerin, P., Patra, P., Pacaud, P., & Loirand, G. (2006). Hyaluronan induces vascular smooth muscle cell migration through RHAMM-mediated PI3K-dependent Rac activation. Cardiovascular Research, 72(2), 339–348. https://doi.org/10.1016/J.CARDIORES.2006.07.017

Loirand, G., Guilluy, C., & Pacaud, P. (2006). Regulation of Rho Proteins by Phosphorylation in the Cardiovascular System. Trends in Cardiovascular Medicine, 16(6), 199–204. https://doi.org/10.1016/j.tcm.2006.03.010

Guilluy, C., Rolli-Derkinderen, M., Tharaux, P.-L., Melino, G., Pacaud, P., & Loirand, G. (2006). Transglutaminase-dependent RhoA Activation and Depletion by Serotonin in Vascular Smooth Muscle Cells. Journal of Biological Chemistry, 282(5), 2918–2928. https://doi.org/10.1074/jbc.M604195200

Guilluy, C., Sauzeau, V., Rolli-Derkinderen, M., Guérin, P., Sagan, C., Pacaud, P., & Loirand, G. (2005). Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension. British Journal of Pharmacology, 146(7), 1010–1018. https://doi.org/10.1038/SJ.BJP.0706408