Colin David Kay
Phytochemical, Metabolism, Microbiome, Metabolome, Cardiometabolic
Works (125)
Updated: April 4th, 2024 02:28
2024 article
Genotype and ripening method affect carotenoid content and bio-accessibility in banana
Munoz, B., Hayes, M., Perkins-Veazie, P., Gillitt, N., Munoz, M., Kay, C. D., … Iorizzo, M. (2024, March 4). FOOD & FUNCTION, Vol. 3.
pubs.rsc.org (publisher PDF)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 8, 2024
2023 journal article
A combined DHA-rich fish oil and cocoa flavanols intervention does not improve cognition or brain structure in older adults with memory complaints: results from the CANN randomized, controlled parallel-design study
AMERICAN JOURNAL OF CLINICAL NUTRITION, 118(2), 369–381.
author keywords: omega-3; polyphenols; flavonoids; mild cognitive impairment; subjective cognitive impairment; aging; cognition
TL;DR:
The results suggest that cosupplementation with ω-3 PUFAs and cocoa flavanols for 12 mo does not improve cognitive outcomes in those with cognitive impairment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023
2023 journal article
Almond intake alters the acute plasma dihydroxy-octadecenoic acid (DiHOME) response to eccentric exercise
FRONTIERS IN NUTRITION, 9.
author keywords: almonds; exercise; oxylipins; inflammation; cytokines; metabolites; (poly)phenols
TL;DR:
Positive effects of almond intake in improving mood state, retaining strength, decreasing muscle damage, increasing the generation of gut-derived phenolic metabolites, and altering the plasma oxylipin DiHOME response to unaccustomed eccentric exercise in untrained adults are supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 13, 2023
2023 journal article
Bioavailable Microbial Metabolites of Flavanols Demonstrate Highly Individualized Bioactivity on In Vitro & beta;-Cell Functions Critical for Metabolic Health
Bioavailable Microbial Metabolites of Flavanols Demonstrate Highly Individualized Bioactivity on In Vitro & beta;-Cell Functions Critical for Metabolic Health. METABOLITES, 13(7).
author keywords: gut microbiome; phytochemicals; flavanol metabolites; glucose sensitivity; responder analysis; personalized nutrition
TL;DR:
It is concluded that metabolite bioactivity on GSIS capacity is less related to flavanol supplementation or antibiotic treatment and may be more associated with the unique microbiome or metabolome of each animal, suggesting flavanol metabolite activities are individualized and point to the need for personalized nutrition practices.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 14, 2023
2023 journal article
Performance of Urinary Phenyl-γ-Valerolactones as Biomarkers of Dietary Flavan-3-ol Exposure
JOURNAL OF NUTRITION, 153(8), 2193–2204.
author keywords: flavonoids; flavan-3-ols; phenyl-gamma-valerolactones; biomarkers; cocoa; apple; black tea; green tea
TL;DR:
Urinary 5-(3-hydroxyphenyl)-γ-valerolactone-4'-sulfate and putatively identified 5-(4'-hydroxymhenyl)γ-Valerolactsone-3'-glucuronide are recommended biomarkers for dietary flavan-3-ol exposure.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 8, 2024
2022 journal article
A randomized placebo-controlled cross-over study on the effects of anthocyanins on inflammatory and metabolic responses to a high-fat meal in healthy subjects
REDOX BIOLOGY, 51.
author keywords: Flavonoids; Obesity; Inflammation; Endotoxemia; Oxidative stress; Antioxidants
MeSH headings : Anthocyanins / pharmacology; Anthocyanins / therapeutic use; Blood Glucose / metabolism; Cross-Over Studies; Diet, High-Fat / adverse effects; Endotoxemia / metabolism; Healthy Volunteers; Humans; Insulin; Leukocytes, Mononuclear / metabolism
TL;DR:
D Dietary AC, i.e. cyanidin and delphinidin, exerted beneficial actions against unhealthy diets by modulating the associated postprandial dysmetabolism, endotoxemia, alterations of glycemia and lipidemia, and redox and insulin signaling.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 20, 2022
2022 journal article
Blueberry anthocyanin intake attenuates the postprandial cardiometabolic effect of an energy-dense food challenge: Results from a double blind, randomized controlled trial in metabolic syndrome participants
CLINICAL NUTRITION, 41(1), 165–176.
author keywords: Metabolic syndrome; Postprandial assessment; Energy-dense meal challenge; Blueberry anthocyanins; Flavonoids; Cardiovascular disease risk
MeSH headings : Aged; Anthocyanins / administration & dosage; Anthocyanins / blood; Anthocyanins / urine; Blood Glucose / metabolism; Blood Pressure / drug effects; Blueberry Plants; Diet, Carbohydrate Loading / adverse effects; Diet, High-Fat / adverse effects; Double-Blind Method; Endothelium, Vascular / drug effects; Energy Intake / drug effects; Female; Humans; Insulin / blood; Lipoproteins / blood; Male; Meals / drug effects; Metabolic Syndrome / metabolism; Middle Aged; Postprandial Period / drug effects; Pulse Wave Analysis; Vascular Stiffness / drug effects
TL;DR:
It is found that adding blueberries to a high-fat/high-sugar meal affected the postprandial cardiometabolic response over 24 h and improved HDL-C and Apo-A1, but not LDL-C, TG, or ApO-B.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 27, 2021
2022 article
Boosting the Bioaccessibility of Dietary Bioactives by Delivery as Protein-Polyphenol Aggregate Particles
Lila, M. A., Hoskin, R. T., Grace, M. H., Xiong, J., Strauch, R., Ferruzzi, M., … Kay, C. (2022, April 8). JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, Vol. 4.
author keywords: bioavailability; digestion; absorption; circulation; uptake; matrix
MeSH headings : Humans; Polyphenols / analysis; Fruit / chemistry; Protein Aggregates; Dietary Proteins; Biological Availability; Food Ingredients
TL;DR:
Evidence to date suggests that complexation of phy toactive polyphenolics effectively enhances their health-relevant impacts, specifically because the phytoactives are protected in the protein matrix during transit in the GIT, allowing intact, non-degraded molecules to reach the colon for catabolism at the gut microbiome level.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 14, 2022
2022 article
Cocoa Extract Exerts Sex-Specific Effects in an Aggressive Hyper-Glycemia Model: A Pilot Study
Racine, K. C., Iglesias-Carres, L., Herring, J. A., Ferruzzi, M. G., Kay, C. D., Tessem, J. S., & Neilson, A. P. (2022, January 31). (Vol. 1). Vol. 1.
Source: ORCID
Added: February 2, 2022
2022 journal article
Cocoa extract exerts sex-specific anti-diabetic effects in an aggressive type-2 diabetes model: A pilot study
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 626, 205–210.
author keywords: BTBR; Ob/ob; Type-2 diabetes; Flavanol; Insulin; Beta cell
MeSH headings : Animals; Cacao; Diabetes Mellitus, Type 2 / drug therapy; Female; Humans; Hyperglycemia; Hyperinsulinism; Male; Mice; Obesity; Pilot Projects; Plant Extracts / pharmacology; Plant Extracts / therapeutic use
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 17, 2022
2022 journal article
Effect of Wild Blueberry Metabolites on Biomarkers of Gastrointestinal and Immune Health In Vitro
Immuno, 2(2), 293–306.
TL;DR:
Wild blueberries are a rich source of dietary fiber and (poly)phenols with gastrointestinal and immune health-promoting properties, however, their mechanisms of action on the intestinal epithelial cells and transient tissue macrophages remain to be elucidated.
(via Semantic Scholar)
Source: ORCID
Added: March 30, 2022
2022 article
Exploring the Contribution of (Poly)phenols to the Dietary Exposome Using High Resolution Mass Spectrometry Untargeted Metabolomics
Li, Y.-Y., Rushing, B., Schroder, M., Sumner, S., & Kay, C. D. (2022, February 25). MOLECULAR NUTRITION & FOOD RESEARCH, Vol. 2.
author keywords: dietary exposome; dietary exposome library (DEL); metabolites; polyphenols; untargeted metabolomics
MeSH headings : Humans; Chromatography, Liquid; Phenols; Tandem Mass Spectrometry / methods; Phenol; Exposome; Metabolomics / methods; Phytochemicals
TL;DR:
The DEL continues to expand with the aim to provide evidence‐based data for dietary metabolites in exposome research and inform the development of dietary intervention strategies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 26, 2022
2022 journal article
Foaming and sensory characteristics of protein-polyphenol particles in a food matrix
Food Hydrocolloids.
author keywords: Particles; Polyphenols; Proteins; Foaming; Sensory; Structure
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: August 26, 2021
2022 journal article
Microbial Metabolites of Flavanols in Urine are Associated with Enhanced Anti-Proliferative Activity in Bladder Cancer Cells In Vitro
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 74(1), 194–210.
MeSH headings : Animals; Chromatography, Liquid; Gastrointestinal Microbiome; Polyphenols / analysis; Rats; Tandem Mass Spectrometry; Urinary Bladder Neoplasms / drug therapy
TL;DR:
It is suggested that microbial metabolites may be the primary compounds responsible for chemoprevention in uroepithelial cell following flavanol consumption, highlighting the potential for exploiting knowledge about individual genetics, microbiome profiles, flavonoid metabolism profiles, tumor characteristics, etc. to design personalized dietary interventions for cancer prevention and/or adjuvant therapy to reduce bladder cancer incidence and improve outcomes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 10, 2021
2022 journal article
Spray-dried and freeze-dried protein-spinach particles; effect of drying technique and protein type on the bioaccessibility of carotenoids, chlorophylls, and phenolics
FOOD CHEMISTRY, 388.
author keywords: Spinach phytochemicals; Whey protein; Soy protein; Drying; In vitro digestion; Dried ingredients
MeSH headings : Carotenoids / metabolism; Chlorophyll / metabolism; Digestion; Excipients / metabolism; Flavonoids / metabolism; Freeze Drying; Phenols / metabolism; Spinacia oleracea / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 13, 2022
2022 review
The berry health tool chest - an evidence map and interactive resource
[Review of ]. NUTRITION REVIEWS, 80(1), 68–77.
author keywords: berry; clinical trial design; dietary intervention; evidence mapping; health criteria
MeSH headings : Eating; Fruit; Humans
TL;DR:
The development and utility of the "Berry Health Tool Chest," an evidence map summarizing trial design features of studies characterizing the impact of berry consumption upon human health biomarkers, are described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 3, 2022
2021 journal article
An enriched biosignature of gut microbiota-dependent metabolites characterizes maternal plasma in a mouse model of fetal alcohol spectrum disorder
SCIENTIFIC REPORTS, 11(1).
MeSH headings : Animals; Disease Models, Animal; Female; Fetal Alcohol Spectrum Disorders / blood; Fetal Alcohol Spectrum Disorders / metabolism; Fetal Alcohol Spectrum Disorders / microbiology; Gastrointestinal Microbiome; Male; Mice; Mothers; Pregnancy
TL;DR:
The maternal microbiome and its MDPs are a previously unrecognized influence upon the pathologies that typify PAE, and are concluded to constitute a characteristic biosignature that distinguishes PAE.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 10, 2021
2021 article
Cocoa Extract Exerts Sex-Specific Effects in an Aggressive Hyper-Glycemia Model: A Pilot Study
Racine, K. C., Iglesias-Carres, L., Herring, J. A., Ferruzzi, M. G., Kay, C. D., Tessem, J. S., & Neilson, A. P. (2021, December 7). (Vol. 12). Vol. 12.
Source: ORCID
Added: December 10, 2021
2021 journal article
High-density linkage map construction and identification of loci regulating fruit quality traits in blueberry
HORTICULTURE RESEARCH, 8(1).
TL;DR:
The genetic basis of fruit quality traits in blueberry was dissected and an association between these fruit quality trait and metabolites detected by Proton nuclear magnetic resonance analysis was established.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 1, 2021
2021 article
Influence of simulated food and oral processing on carotenoid and chlorophyll in vitro bioaccessibility among six spinach genotypes
Hayes, M., Corbin, S., Nunn, C., Pottorff, M., Kay, C. D., Lila, M. A., … Ferruzzi, M. G. (2021, May 14). FOOD & FUNCTION, Vol. 5.
MeSH headings : Biological Availability; Carotenoids / chemistry; Carotenoids / metabolism; Carotenoids / pharmacokinetics; Chlorophyll / chemistry; Chlorophyll / metabolism; Chlorophyll / pharmacokinetics; Digestion; Genotype; Models, Biological; Spinacia oleracea / chemistry; Spinacia oleracea / genetics
TL;DR:
It is suggested that the genotype, processing treatment, and genotype × processing (G × P) interaction may affect carotenoid and chlorophyll bioaccessibility in spinach and that food processing remains a dominant factor in modulating the bioavailability of these phytochemicals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 22, 2021
2021 journal article
Strawberry Consumption, Cardiometabolic Risk Factors, and Vascular Function: A Randomized Controlled Trial in Adults with Moderate Hypercholesterolemia
JOURNAL OF NUTRITION, 151(6), 1517–1526.
author keywords: strawberry; hypercholesterolemia; cardiovascular risk factors; flow-mediated dilation; (poly)phenolic metabolites
MeSH headings : Adult; Blood Pressure; Cardiometabolic Risk Factors; Cardiovascular Diseases / prevention & control; Cholesterol, LDL; Cross-Over Studies; Dietary Supplements; Female; Fragaria; Fruit; Humans; Hypercholesterolemia; Male; Middle Aged; Powders
TL;DR:
Data support inclusion of strawberries in a heart-healthy diet in adults with moderate hypercholesterolemia and suggest the effect may be related to changes in microbial-derived phenolic metabolites after strawberry consumption influencing endothelial function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 2, 2021
2020 journal article
Blueberry and/or Banana Consumption Mitigate Arachidonic, Cytochrome P450 Oxylipin Generation During Recovery From 75-Km Cycling: A Randomized Trial
FRONTIERS IN NUTRITION, 7.
author keywords: exercise; lipid mediators; carbohydrate; polyphenols; metabolites; inflammation; fatty acids
TL;DR:
Heavy exertion evoked a transient but robust increase in plasma levels of oxylipins in cyclists, with a strong attenuation effect linked to both chronic blueberry and acute banana intake on pro-inflammatory ARA-CYP oxylIPins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 21, 2020
2020 journal article
Development of a genetic framework to improve the efficiency of bioactive delivery from blueberry
SCIENTIFIC REPORTS, 10(1).
MeSH headings : Blueberry Plants / genetics; Blueberry Plants / metabolism; Digestion; Flavonoids / metabolism; Genotype; Hydroxybenzoates / metabolism; In Vitro Techniques
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 16, 2020
2020 journal article
In Vitro Bioaccessibility of Carotenoids and Chlorophylls in a Diverse Collection of Spinach Accessions and Commercial Cultivars
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 68(11), 3495–3505.
author keywords: spinach; carotenoids; lutein; beta-carotene; chlorophyll; genotypes; bioaccessibility; in vitro digestion
MeSH headings : Carotenoids; Chlorophyll; Chlorophyll A; Spinacia oleracea / genetics; beta Carotene
TL;DR:
The results suggest that carotenoid and chlorophyll bioaccessible contents may vary based on spinach genotypes and may be stable across seasons.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 8, 2020
2020 journal article
Recommendations for standardizing nomenclature for dietary (poly)phenol catabolites
AMERICAN JOURNAL OF CLINICAL NUTRITION, 112(4), 1051–1068.
author keywords: dietary (poly)phenols; microbial catabolites; phase II metabolites; nomenclature; food/diet metabolome
MeSH headings : Diet; Humans; Isomerism; Polyphenols / administration & dosage; Polyphenols / metabolism; Terminology as Topic
TL;DR:
A nomenclature system for phenolic catabolites and their human phase II metabolites is proposed in this article and the basis of its format outlined is outlined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 16, 2020
2020 article
Supplemental treatment options for diabetes: how flavanol metabolites improve beta-cell function
Lloyd, T., Griffin, L., Krueger, E., Beales, J., Barlow, A., Sheets, J., … Tessem, J. (2020, April). FASEB JOURNAL, Vol. 34.
TL;DR:
Data is presented regarding the in vitro effects of these absorbed gut bacteria derived flavanoids on INS‐1 832/13 β‐cell insulin secretion and proliferation and further light is shed on the potential ability of flavanoid and their gut bacteriaderived metabolites to enhance functional β‐ cell mass.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2020
2020 review
Terms and nomenclature used for plant-derived components in nutrition and related research: efforts toward harmonization
[Review of ]. NUTRITION REVIEWS, 78(6), 451–458.
author keywords: bioactive; carotenoid; flavonoid; nomenclature; nutraceutical; phytochemical; phytonutrient; polyphenol
MeSH headings : Biomedical Research; Humans; Nutritional Sciences; Phytochemicals; Plant Preparations; Terminology as Topic
TL;DR:
The aim in this article is to establish scientific criteria for definitions that could be applied to clearly define and differentiate commonly used terms and thus ensure their consistent application in the scientific literature.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 29, 2020
2019 journal article
Adaptation of an in Vitro Digestion Model for High Throughput Phenolic Bioaccessibility Phenotyping Within Cultivated (highbush) Blueberry Varieties (P06-004-19)
Current Developments in Nutrition, 3(Supplement 1).
TL;DR:
A HT in vitro digestion model provides a novel tool for phenotyping phenolic bioaccessibility in blueberry fruit and application to a subset of DxJ genotypes further suggest that variation in phenolicBioaccessibility exist and highlights the need for investigation of diversity panels and mapping populations.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: November 6, 2020
2019 journal article
Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome—results from a 6-month, double-blind, randomized controlled trial
The American Journal of Clinical Nutrition, 109(6), 1535–1545.
author keywords: metabolic syndrome; blueberry anthocyanins; flavonoids; cardiovascular disease risk; anthocyanin-derived phenolic acid metabolites
MeSH headings : Aged; Apolipoproteins / blood; Biomarkers / blood; Blood Pressure; Blueberry Plants / metabolism; Cholesterol, HDL / blood; Cholesterol, LDL / blood; Double-Blind Method; Female; Fruit / metabolism; Heart / physiopathology; Humans; Insulin Resistance; Male; Metabolic Syndrome / blood; Metabolic Syndrome / diet therapy; Metabolic Syndrome / physiopathology; Middle Aged; Prospective Studies; Pulse Wave Analysis
TL;DR:
Despite insulin resistance remaining unchanged, blueberries should be included in dietary strategies to reduce individual and population CVD risk, and first sustained improvements in vascular function, lipid status, and underlying NO bioactivity following 1 cup blueberries/d are shown.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: December 5, 2019
2019 journal article
Contribution of Berry Polyphenols to the Human Metabolome
Molecules.
author keywords: mass spectrometry; metabolome; metabolomics; microbiome; (poly)phenol
MeSH headings : Anthocyanins / chemistry; Anthocyanins / pharmacokinetics; Blueberry Plants / chemistry; Fragaria / chemistry; Fruit / chemistry; Humans; Metabolome; Polyphenols / chemistry; Polyphenols / pharmacokinetics
TL;DR:
Berry consumption in general appears to cause a fluctuation in the pools of small molecule metabolites already present at baseline, rather than the appearance of unique berry-derived metabolites, which likely reflects the ubiquitous nature of (poly)phenols in the background diet.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: November 25, 2019
2019 journal article
Diversity in the Bioaccessibility of Carotenoid and Chlorophyll Compounds in 69 Spinach Genotypes (P06-007-19)
Current Developments in Nutrition, 3(Supplement 1).
TL;DR:
Results suggest that carotenoid and chlorophyll bio Accessibility may vary based on spinach genotype, and the relationship of bioaccessibility to quality traits and potential interactions with agronomic and processing conditions remain to be explored.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: November 6, 2020
2019 journal article
Managing Risks Associated with Establishing the Metabolome of Dietary Phytochemicals (P06-010-19)
Current Developments in Nutrition, 3(Supplement 1).
TL;DR:
Limits of mass spectrometry are highlighted to ensure researchers make appropriate assumptions from their spectral data to ensure falsely identified metabolites will continue to occur and undoubtedly hinder future discovery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: November 6, 2020
2018 journal article
Cardiovascular Mechanisms of Action of Anthocyanins May Be Associated with the Impact of Microbial Metabolites on Heme Oxygenase-1 in Vascular Smooth Muscle Cells
Molecules, 23(4), 898.
author keywords: anthocyanin; smooth muscle cells; metabolism; antioxidant; atherosclerosis
MeSH headings : Animals; Anthocyanins / chemistry; Anthocyanins / pharmacology; Aorta; Cell Proliferation / drug effects; Cells, Cultured; Gene Expression Regulation / drug effects; Heme Oxygenase (Decyclizing) / metabolism; Molecular Structure; Muscle, Smooth, Vascular / cytology; Muscle, Smooth, Vascular / drug effects; Muscle, Smooth, Vascular / metabolism; Phenols / chemistry; Phenols / pharmacology; Rats; Rats, Sprague-Dawley
TL;DR:
It is demonstrated that phenolic metabolites of anthocyanins differentially affect HO-1 activity, often having additive, synergistic or nullifying effects.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 5, 2019
2018 journal article
Effect of adding milk to black tea on vascular function in healthy men and women: a randomised controlled crossover trial
Food & Function, 9(12), 6307–6314.
MeSH headings : Adult; Animals; Blood Pressure; Brachial Artery / physiology; Camellia sinensis / chemistry; Camellia sinensis / metabolism; Cross-Over Studies; Female; Heart Rate; Humans; Male; Milk / metabolism; Tea / metabolism; Vasodilation; Young Adult
TL;DR:
The addition of milk to black tea alters the acute/short-term impact of regular tea consumption on vascular function and blood pressure in young healthy men and women.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: December 8, 2019
2018 article
Increased Plasma Levels of Gut-Derived Phenolics Linked to Walking and Running Following 2-Weeks Flavonoid Supplementation
Nieman, D. C., Kay, C. D., Rathore, A. S., Grace, M. H., Strauch, R. C., Stephan, E. H., … Lila, M. A. (2018, October 15). (Vol. 10). Vol. 10.
Source: ORCID
Added: November 13, 2019
2018 journal article
Increased Plasma Levels of Gut-Derived Phenolics Linked to Walking and Running Following Two Weeks of Flavonoid Supplementation
Nutrients, 10(11).
Contributors: D. Nieman *, n , A. Rathore n, M. Grace n , R. Strauch n, E. Stephan*, C. Sakaguchi *, M. Lila n
author keywords: exercise; polyphenol; metabolite; hippurate; intestinal tract; colon
TL;DR:
Data indicate that acute exercise bouts (brisk walking, intensive running) are linked to an increased translocation of gut-derived phenolics into circulation, an effect that is amplified when combined with a two-week period of increased flavonoid intake or chronic training as a runner.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: November 12, 2019
2018 journal article
The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective
Comprehensive Reviews in Food Science and Food Safety, 17(5), 1054–1112.
author keywords: bioactivity; bioavailability; dietary flavonoids; metabolism; transport
TL;DR:
This review traces the development of the field over the past 8 decades, and indicates the current state of the art, and how it was reached.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: December 5, 2019
2017 article
Anthocyanins and Flavanones Are More Bioavailable than Previously Perceived: A Review of Recent Evidence
ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 8, Vol. 8, pp. 155–180.
author keywords: anthocyanins; flavanones; bioavailability; bioactivity
MeSH headings : Anthocyanins / pharmacokinetics; Anthocyanins / urine; Biological Availability; Colon / metabolism; Colon / microbiology; Diet; Flavanones / pharmacokinetics; Flavanones / urine; Fruit / metabolism; Gastrointestinal Microbiome; Humans; Kidney / metabolism; Phenols / pharmacokinetics; Vegetables / metabolism
TL;DR:
It is evident that lower molecular weight phenolic and aromatic ring-fission catabolites, produced primarily by the action of the colonic microbiota, are much more bioavailable than previously envisaged.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Influence of Ingesting a Flavonoid-Rich Supplement On the Human Metabolome and Concentration of Urine Phenolics
The FASEB Journal, 31(Supplement 1), 972.26.
TL;DR:
This randomized clinical trial of overweight/obese women showed that 12‐weeks ingestion of a mixed flavonoid‐nutrient supplement was associated with a corresponding increase in urine total phenolics and gut‐derived phenolic metabolites, which supports the strategy of using metabolomics procedures to better define physiological responses in humans.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: November 6, 2020
2017 journal article
Influence of Ingesting a Flavonoid-Rich Supplement on the Metabolome and Concentration of Urine Phenolics in Overweight/Obese Women
JOURNAL OF PROTEOME RESEARCH, 16(8), 2924–2935.
Contributors: D. Nieman *, S. Ramamoorthy*, n , C. Goodman*, C. Capps*, Z. Shue*, N. Heyl*, M. Grace n , M. Lila n
author keywords: dietary supplement; metabolomics; polyphenol; obesity
MeSH headings : Adolescent; Adult; Aged; Dietary Supplements; Female; Flavonoids / administration & dosage; Flavonoids / pharmacology; Humans; Intestinal Mucosa / metabolism; Metabolome / drug effects; Metabolomics / methods; Middle Aged; Obesity / metabolism; Obesity / urine; Overweight / metabolism; Overweight / urine; Phenols / urine; Young Adult
TL;DR:
It was shown that 12 weeks ingestion of a mixed flavonoid nutrient supplement was associated with a corresponding increase in urine total phenolics and gut-derived phenolic metabolites.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
Signatures of anthocyanin metabolites identified in humans inhibit biomarkers of vascular inflammation in human endothelial cells
Molecular Nutrition & Food Research, 61(9).
MeSH headings : Anthocyanins / metabolism; Anthocyanins / pharmacology; Biomarkers; Cells, Cultured; Endothelial Cells / drug effects; Glucosides / pharmacology; Humans; Interleukin-6 / analysis; Interleukin-6 / antagonists & inhibitors; Interleukin-6 / genetics; Transcription Factor RelA / metabolism; Tumor Necrosis Factor-alpha / pharmacology; Vascular Cell Adhesion Molecule-1 / analysis; Vascular Cell Adhesion Molecule-1 / antagonists & inhibitors; Vascular Cell Adhesion Molecule-1 / genetics
TL;DR:
Signatures of anthocyanin metabolites following dietary consumption reduce VCAM‐1 and IL‐6 production, providing evidence of physiologically relevant biological activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2016 journal article
Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trial, 2
The American Journal of Clinical Nutrition, 103(3), 694–702.
Source: ORCID
Added: November 13, 2019
2016 journal article
Common Phenolic Metabolites of Flavonoids, but Not Their Unmetabolized Precursors, Reduce the Secretion of Vascular Cellular Adhesion Molecules by Human Endothelial Cells--3
The Journal of Nutrition, 146(3), 465–473.
Source: ORCID
Added: November 13, 2019
2016 conference paper
Elucidating metabolic signatures of phytochemical consumption
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 252.
Event: AMER CHEMICAL SOC 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
Source: ORCID
Added: November 13, 2019
2015 journal article
Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells
Molecular Nutrition & Food Research, 59(6), 1095–1106.
author keywords: Adhesion molecule; Cytokine; Cyanidin-3-glucoside; Inflammation; Metabolites
MeSH headings : Anthocyanins / pharmacology; CD40 Ligand / metabolism; Coumaric Acids / metabolism; Endothelial Cells / cytology; Endothelial Cells / drug effects; Endothelial Cells / metabolism; Gene Expression; Glucosides / pharmacology; Glucuronides / metabolism; Human Umbilical Vein Endothelial Cells; Humans; Hydroxybenzoates / metabolism; Interleukin-6 / genetics; Interleukin-6 / metabolism; Lipoproteins, LDL / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Vascular Cell Adhesion Molecule-1 / genetics; Vascular Cell Adhesion Molecule-1 / metabolism
TL;DR:
Novel data are provided to suggest that anthocyanin metabolites are bioactive at physiologically relevant concentrations and have the potential to modulate cardiovascular disease progression by altering the expression of inflammatory mediators.
(via Semantic Scholar)
Source: Crossref
Added: February 9, 2020
2015 journal article
Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells
Molecular Nutrition & Food Research, 59(6), 1095–1106.
Source: ORCID
Added: November 13, 2019
2015 journal article
Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes
Molecular Nutrition & Food Research, 59(6), 1143–1154.
author keywords: Cytokine; Inflammation; Metabolism; Phase 2 conjugates; Polyphenol
MeSH headings : Cell Line; Cell Survival / drug effects; Flavonoids / chemistry; Flavonoids / pharmacology; Humans; Hydroxybenzoates / pharmacology; Interleukin-10 / metabolism; Interleukin-1beta / metabolism; Lipopolysaccharides / adverse effects; Monocytes / drug effects; NF-kappa B / genetics; NF-kappa B / metabolism; Parabens / pharmacology; RNA, Messenger / genetics; RNA, Messenger / metabolism; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Novel evidence suggesting flavonoid bioactivity results from cumulative or additive effects of circulating metabolites is provided, suggesting singular or additive anti‐inflammatory effects of flavonoids relative to their precursor structures.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2015 journal article
Orange juice--derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease--
The American Journal of Clinical Nutrition, 101(5), 931–938.
Source: ORCID
Added: November 13, 2019
2015 journal article
Phenolic Metabolites of Anthocyanins Modulate Mechanisms of Endothelial Function
Journal of Agricultural and Food Chemistry, 63(9), 2423–2431.
author keywords: endothelium; eNOS; cyanidin; HUVEC; NADPH-oxidase
MeSH headings : Anthocyanins / metabolism; Cell Line; Human Umbilical Vein Endothelial Cells / metabolism; Humans; Nitric Oxide / metabolism; Nitric Oxide Synthase Type III / metabolism; Phenols / metabolism; Superoxides / metabolism
TL;DR:
Anthocyanin metabolites may modulate vascular reactivity by inducing HO-1 and modulating NOX activity, resulting in reduced superoxide production and improved NO bioavailability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, ORCID
Added: November 13, 2019
2015 journal article
Rethinking paradigms for studying mechanisms of action of plant bioactives
Nutrition Bulletin, 40(4), 335–339.
author keywords: anti-inflammatory; bioactivity flavonoid; metabolism; microflora; vascular
TL;DR:
Recent research suggests a highly complex interplay between metabolism, intestinal microflora, the immune system and various tissues of the authors' body, which suggests protection against cardio-metabolic diseases and disorders.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2015 conference paper
Sulfurophane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo
International Journal of Experimental Pathology, 96(2), A24.
Event: Joint meeting of British Societies for Matrix Biology and Developmental Biology at University of East Anglia (Norwich) on September 1-3, 2014
Source: NC State University Libraries
Added: March 12, 2021
2015 journal article
The bioactivity of flavonoids is likely the result of cumulative low exposure to a variety of structurally similar phenolic metabolites
The FASEB Journal, 29(Supplement 1), 118.4.
TL;DR:
The evidence suggests that bioactivity of flavonoids in vivo results from low exposure to a variety of structurally similar metabolites modifying inflammation and cellular adhesion pathways.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: November 6, 2020
2014 journal article
A moderate-fat diet containing pistachios improves emerging markers of cardiometabolic syndrome in healthy adults with elevated LDL levels
British Journal of Nutrition, 112(5), 744–752.
author keywords: Pistachios; Small and dense LDL; HDL subclasses; Insulin resistance; Cardiometabolic disease; C-reactive protein; Plant sterols
MeSH headings : Anticholesteremic Agents / administration & dosage; Biomarkers / blood; C-Reactive Protein / analysis; Cardiovascular Diseases / blood; Cardiovascular Diseases / prevention & control; Cholesterol / blood; Cross-Over Studies; Dietary Fats / administration & dosage; Female; Humans; Insulin Resistance; Lipoproteins / blood; Lipoproteins, LDL / blood; Male; Metabolic Syndrome / blood; Metabolic Syndrome / prevention & control; Middle Aged; Nuts / chemistry; Phytosterols / administration & dosage; Phytotherapy; Pistacia; Sitosterols / blood; Triglycerides / blood
TL;DR:
In conclusion, the inclusion of pistachios in a moderate-fat diet favourably affects the cardiometabolic profile in individuals with an increased risk of CVD.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019
2014 journal article
Methods for Isolating, Identifying, and Quantifying Anthocyanin Metabolites in Clinical Samples
Analytical Chemistry, 86(20), 10052–10058.
MeSH headings : Anthocyanins / analysis; Chromatography, High Pressure Liquid; Tandem Mass Spectrometry
TL;DR:
The described methods provide suitable versatility for the identification and quantification of an extensive series of anthocyanin metabolites for use in future clinical studies exploring absorption, distribution, metabolism, and elimination.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, ORCID
Added: November 13, 2019
2014 journal article
Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo
Osteoarthritis and Cartilage, 22, S322–S323.
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2014 journal article
The pharmacokinetics of anthocyanins and their metabolites in humans
British Journal of Pharmacology, 171(13), 3268–3282.
Source: ORCID
Added: November 13, 2019
2013 article
A moderate-fat diet with pistachios lowers small-dense LDL and improves markers of insulin sensitivity in subjects with moderately-elevated cholesterol Levels
Federation of American Societies for Experimental Biology.
Source: ORCID
Added: November 13, 2019
2013 journal article
Absorption, distribution, metabolism and elimination of a stable isotope-labelled anthocyanin in humans
FASEB Journal, 27(Supplement 1), 125.6.
Event: Experimental Biology 2013 Meeting
Source: NC State University Libraries
Added: March 9, 2021
2013 journal article
Encyclopedia of Human Nutrition: Phytochemicals: Classification and Occurrence
Source: ORCID
Added: November 13, 2019
2013 journal article
Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a 13C-tracer study--
The American of Clinical Nutrition, 97(5), 995–1003.
Source: ORCID
Added: November 13, 2019
2013 journal article
Metabolism of dietary flavonoids alters their effect on tumor necrosis factor-α
Cytokine, 63(3), 259.
Event: SI: 2013 ICS at San Francisco, CA on September 29 - October 3, 2013
TL;DR:
Metabolism of parent flavonoids may increase their anti-inflammatory bioactivity, and protein data are not corroborated at the mRNA level, suggesting the treatments are having a post-translational effect.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: November 6, 2020
2013 journal article
Phenolic metabolites of anthocyanins following a dietary intervention study in post-menopausal women
Molecular Nutrition & Food Research, 58(3), 490–502.
author keywords: Anthocyanins; Elderberries; Glucuronide; Phenolic acids; Sulfate
MeSH headings : Anthocyanins / blood; Anthocyanins / metabolism; Anthocyanins / pharmacology; Anthocyanins / urine; Dietary Supplements; Female; Humans; Middle Aged; Phenols / blood; Phenols / metabolism; Phenols / urine; Plant Extracts / analysis; Plant Extracts / chemistry; Postmenopause; Sambucus / chemistry
TL;DR:
An extensive range of phenolic metabolites of anthocyanin was identified following elderberry consumption in humans, including 11 novel metabolites, which were identified at much higher concentrations than their parent compounds.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2013 chapter
Potential Health Benefits of Blackcurrants
In Bioactives in Fruit (pp. 215–250).
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2013 chapter
Potential Health Benefits of Blackcurrants
In M. Skinner & D. Hunter (Eds.), Bioactives in fruit: health benefits and functional foods (pp. 215–250).
Ed(s): M. Skinner & D. Hunter
Sources: NC State University Libraries, NC State University Libraries
Added: March 19, 2021
2013 journal article
Sulforaphane Represses Matrix-Degrading Proteases and Protects Cartilage From Destruction In Vitro and In Vivo
Arthritis & Rheumatism, 65(12), 3130–3140.
MeSH headings : Animals; Arthritis, Experimental / metabolism; Cartilage, Articular / drug effects; Cartilage, Articular / metabolism; Cattle; Chondrocytes / drug effects; Chondrocytes / metabolism; Humans; Isothiocyanates / pharmacology; Matrix Metalloproteinases / metabolism; Mice; NF-E2-Related Factor 2 / metabolism; NF-kappa B / metabolism; Osteoarthritis / metabolism; Signal Transduction / drug effects; Signal Transduction / physiology; Sulfoxides
TL;DR:
Sulforaphane inhibits the expression of key metalloproteinases implicated in osteoarthritis, independently of Nrf2, and blocks inflammation at the level of NF-κB to protect against cartilage destruction in vitro and in vivo.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019
2013 journal article
Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo
Osteoarthritis and Cartilage, 21, S217–S218.
Source: Crossref
Added: March 8, 2020
2013 journal article
The metabolic fate of anthocyanins in humans
FASEB Journal, 27(Supplement 1), 125.7.
Event: Experimental Biology 2013 Meeting at Boston, MA
TL;DR:
Results indicate that ACNs are extensively metabolised in vivo, with little suggestion of plasma accumulation following repeated exposure, and most likely relates to the high concentrations of circulating phenolic metabolites.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: March 19, 2021
2013 journal article
Vascular bioactivity of anthocyanin degradants: inhibition of endothelial superoxide production
Proceedings of the Nutrition Society, 72(OCE4).
TL;DR:
The phenolic degradant vanillic acid was selected to explore molecular mechanisms potentially underlying the observed bioactivity of selected anthocyanins and phenolics, and elucidate their potential molecular mechanisms of action.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019
2012 journal article
Dietary Flavonoids and Risk of Stroke in Women
Stroke, 43(4), 946–951.
author keywords: citrus fruits; flavanones; flavonoids; hemorrhagic; ischemic; polyphenols; stroke
MeSH headings : Adult; Brain Ischemia / epidemiology; Brain Ischemia / prevention & control; Citrus; Dietary Supplements; Female; Flavonoids / administration & dosage; Follow-Up Studies; Fruit; Humans; Incidence; Intracranial Hemorrhages / epidemiology; Intracranial Hemorrhages / prevention & control; Middle Aged; Retrospective Studies; Stroke / epidemiology; Stroke / prevention & control; Surveys and Questionnaires; United States; United States Department of Agriculture
TL;DR:
Citrus fruit consumption may be associated with a reduction in stroke risk, and experimental data support these epidemiological associations that the flavanone content of citrus fruits may potentially be cardioprotective.
(via Semantic Scholar)
Source: Crossref
Added: January 5, 2020
2012 journal article
Dietary flavonoids and risk of stroke in women
Stroke, STROKEAHA-111.
Source: ORCID
Added: November 13, 2019
2012 journal article
Diets Containing Pistachios Reduce Systolic Blood Pressure and Peripheral Vascular Responses to Stress in Adults With Dyslipidemia
Hypertension, 60(1), 58–63.
author keywords: diet; stress; blood pressure; endothelium; total peripheral resistance; nuts; pistachios
MeSH headings : Adult; Blood Pressure / physiology; Brachial Artery / diagnostic imaging; Brachial Artery / physiopathology; Cardiac Output / physiology; Cross-Over Studies; Diet, Fat-Restricted / methods; Dose-Response Relationship, Drug; Dyslipidemias / physiopathology; Fasting; Heart Rate / physiology; Humans; Outcome Assessment, Health Care; Pistacia; Stress, Physiological / physiology; Ultrasonography; Vascular Resistance / physiology
TL;DR:
Reductions in peripheral vascular constriction and the resulting decrease in hemodynamic load may be important contributors to lower risk in nut consumers.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019
2012 journal article
Effect of cyanidin-glucoside and its metabolites on inflammatory biomarkers of vascular function
Proceedings of the Nutrition Society, 71(OCE2).
TL;DR:
The ability of cyanidin-glucoside (C3G), the most abundant dietary anthocyanin, and its metabolites to modulate the expression of CAMs and cytokines in cultured human umbilical vein endothelial cells (HUVECs) challenged with either CD40L or oxLDL is investigated.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019
2012 journal article
Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials--
The American Journal of Clinical Nutrition, 95(3), 740–751.
Source: ORCID
Added: November 13, 2019
2012 journal article
Effects of pistachios and walnuts on hemodynamic reactivity to stress: Clinical trials in adults with dyslipidemia
Australasian Medical Journal (Online, 5(12), 676.
Source: NC State University Libraries
Added: November 6, 2020
2012 journal article
Flavonoid metabolism: the synthesis of phenolic glucuronides and sulfates as candidate metabolites for bioactivity studies of dietary flavonoids
Tetrahedron, 68(22), 4194–4201.
author keywords: Flavanoids; Metabolites; Phenolic glucuronides; Phenolic sulfates; Synthesis
TL;DR:
The synthesis of a series of phenolic glucuronide 1a–e and sulfate 2a-e derivates as candidate metabolites for use as reference compounds in metabolic profiling studies and for the exploration of flavonoid bioactivity are detailed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2012 journal article
Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women--
The American Journal of Clinical Nutrition, 96(4), 781–788.
Source: ORCID
Added: November 13, 2019
2012 journal article
Investigating the bioavailability of anthocyanin metabolites
Proceedings of the Nutrition Society, 71(OCE2).
TL;DR:
Clinical samples from a 12-week anthocyanin intervention where 52 postmenopausal females were fed 500 mg/day elderberry extract were analysed and nine metabolites were identified, including nine currently unidentified metabolites which are the focus of future investigation.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019
2012 journal article
Relative impact of flavonoid composition, dose and structure on vascular function: A systematic review of randomised controlled trials of flavonoid-rich food products
Molecular Nutrition & Food Research, 56(11), 1605–1616.
author keywords: Blood pressure; Cardiovascular disease; Dose response; Flavonoids; Flow-mediated dilation
MeSH headings : Biomarkers / metabolism; Blood Pressure / drug effects; Cardiovascular Diseases / diet therapy; Cardiovascular Diseases / drug therapy; Cardiovascular Diseases / metabolism; Catechin / pharmacology; Dose-Response Relationship, Drug; Endothelium, Vascular / drug effects; Endothelium, Vascular / physiology; Flavonoids / chemistry; Flavonoids / pharmacology; Flavonoids / therapeutic use; Humans; Proanthocyanidins / pharmacology; Randomized Controlled Trials as Topic; Regression Analysis; Structure-Activity Relationship; United States
TL;DR:
The present analysis suggests that flavonoid bioactivity does not follow a classical linear dose-response association and this may have important biological implications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: March 8, 2020
2012 journal article
Relative impact of flavonoid composition, dose and structure on vascular function: a systematic review of randomised controlled trials of flavonoid-rich food products
Molecular Nutrition & Food Research, 56(11), 1605–1616.
Source: ORCID
Added: November 13, 2019
2012 journal article
Synthesis of [6, 8, 10, 3’, 5’-C-13 (5)]-cyanidin-3-glucoside, for human in vivo metabolism studies
Journal of Labelled Compounds & Radiopharmaceuticals, 55(3), 131–132.
Source: NC State University Libraries
Added: November 6, 2020
2012 journal article
The impact of human metabolism on the bioactivity of anthocyanins
Proceedings of the Nutrition Society, 71(OCE2).
TL;DR:
This work explored the bioactivity ofthese metabolites on vascular health by measuring the effects on mediators of nitric oxide bioavailability including endothelial nitric oxidesynthase (eNOS), NADPH oxidase (NOX4) and superoxide.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019
2012 journal article
Vascular bioactivity of anthocyanins and phenolic acid degradants: modulation of superoxide and nitric oxide
Proceedings of the Nutrition Society, 71(OCE2).
TL;DR:
Investigation of vascular bioactivity of selected anthocyanins and phenolic degradants, and potential synergy between flavonoids and ascorbic acid found superoxide was significantly decreased by protocatechuic acid in combination with two Flavonoids, epicatechin and quercetin, and asCorbic Acid; although to a lesser extent than with protocatechaic acid alone.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2011 journal article
A gram scale synthesis of a multi-13 C-labelled anthocyanin,[6, 8, 10, 3′, 5′-13 C 5] cyanidin-3-glucoside, for use in oral tracer studies in humans
Chemical Communications, 47(38), 10596–10598.
Source: ORCID
Added: November 13, 2019
2011 journal article
A gram scale synthesis of a multi-13C-labelled anthocyanin, [6,8,10,3′,5′-13C5]cyanidin-3-glucoside, for use in oral tracer studies in humans
Chemical Communications, 47(38), 10596.
MeSH headings : Administration, Oral; Anthocyanins / chemical synthesis; Anthocyanins / chemistry; Anthocyanins / pharmacokinetics; Carbon Isotopes / chemistry; Glucosides / chemical synthesis; Glucosides / chemistry; Glucosides / pharmacokinetics; Humans; Isotope Labeling; Stereoisomerism
TL;DR:
The major dietary anthocyanin, cyanidin-3-glucoside, was prepared from three units of diethyl [2-( 13)C]malonate and one unit of [1,3-(13)C(2)]acetone, such that five isotope locations were distributed throughout the molecule to provide a penta-C(5)-labelled anthocianin for human stable-isotope tracer studies.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020
2011 journal article
A potential mechanism of action of dietary anthocyanins: modulation of endothelial superoxide production by phenolic acid metabolites
Proceedings of the Nutrition Society, 70(OCE4).
TL;DR:
Evidence is presented that anthocyanins and their metabolites attenuate Ang II-induced endothelial superoxide production and that the cellular activity of anthocianins was enhanced following degradation and metabolism to phenolic acid metabolites.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2011 journal article
Anthocyanin-derived phenolic acids form glucuronides following simulated gastrointestinal digestion and microsomal glucuronidation
Molecular Nutrition & Food Research, 55(3), 378–386.
Source: ORCID
Added: November 13, 2019
2011 journal article
Anthocyanins Remain Stable during Commercial Blackcurrant Juice Processing
Journal of Food Science, 76(6), S408–S414.
author keywords: anthocyanin; flavonoids; food processing; juice
MeSH headings : Anthocyanins / analysis; Anthocyanins / chemistry; Antioxidants / chemistry; Beverages / analysis; Chromatography, High Pressure Liquid; Filtration; Food Additives / chemistry; Food Additives / metabolism; Food Handling; Fruit / chemistry; Gallic Acid / analysis; Hot Temperature; Hydrolysis; Hydroxybenzoates / analysis; Models, Chemical; Pasteurization; Pectins / analysis; Pectins / metabolism; Phenols / analysis; Polygalacturonase / metabolism; Ribes / chemistry; Sulfites / chemistry; United Kingdom
TL;DR:
Assessment of the recovery and formation of anthocyanins and their free phenolic acid degradation products during the commercial processing of blackcurrant juice concentrate provides crucial data directly applicable to commercial juice processing, such as improving Anthocyanin yield and practical considerations for anthocianin stability and degradation.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2011 conference paper
Effects of pistachios on emerging CVD risk factors in moderately hypercholesterolemic individuals
The FASEB Journal, 25(S1), 971.21.
Event: Federation of American Societies for Experimental Biology 2011 Meeting at Washington, DC
Sources: NC State University Libraries, NC State University Libraries
Added: March 19, 2021
2011 journal article
Effects of sugar-sweetened and sugar-free cocoa on endothelial function in overweight adults
International Journal of Cardiology, 149(1), 83–88.
author keywords: Cocoa; Endothelial function; Cardiac risk
MeSH headings : Adult; Biomarkers / metabolism; Brachial Artery / drug effects; Brachial Artery / physiology; Cacao; Cardiovascular Diseases / diet therapy; Cardiovascular Diseases / epidemiology; Cardiovascular Diseases / prevention & control; Cholesterol / blood; Cross-Over Studies; Dietary Sucrose / administration & dosage; Endothelium, Vascular / drug effects; Endothelium, Vascular / physiology; Female; Humans; Male; Middle Aged; Overweight / diet therapy; Overweight / epidemiology; Placebos; Risk Factors; Vasodilation / drug effects; Vasodilation / physiology
TL;DR:
Daily cocoa ingestion improves EF independently of other biomarkers of cardiac risk, and does not cause weight gain, and sugar-free preparations may further augment endothelial function.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019
2011 chapter
Phytochemicals
In Nutrition and Metabolism (pp. 339–352).
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2011 journal article
Reply to C Drossard et al
The American Journal of Clinical Nutrition, 93(4), 866–867.
Sources: Web Of Science, NC State University Libraries
Added: January 5, 2020
2010 journal article
Anthocyanin-derived phenolic acids form glucuronides following simulated gastrointestinal digestion and microsomal glucuronidation
Molecular Nutrition & Food Research, 55(3), 378–386.
author keywords: Anthocyanins; Glucuronide; Metabolism; Phenolic acids
MeSH headings : Analysis of Variance; Anthocyanins / metabolism; Chromatography, High Pressure Liquid; Digestion; Glucosides / metabolism; Glucuronides / chemical synthesis; Glucuronides / metabolism; Humans; Hydroxybenzoates / chemical synthesis; Hydroxybenzoates / metabolism; Intestinal Mucosa / metabolism; Male; Microsomes, Liver / metabolism; Parabens / metabolism
TL;DR:
It is proposed that following ingestion, anthocyanins may be found in the systemic circulation as free or conjugated phenolic acids, which should be a focus of future dietary interventions.
(via Semantic Scholar)
Source: Crossref
Added: September 11, 2020
2010 journal article
Anthocyanins form potentially-bioactive phenolic degradation products under simulated physiological conditions
Proceedings of the Nutrition Society, 69(OCE1).
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2010 journal article
CVD risk biomarkers and liver and kidney function are not modified following 12-week ingestion of an elderberry extract rich in anthocyanins
Proceedings of the Nutrition Society, 69(OCE1).
TL;DR:
The intake of anthocyanins, a subclass of flavonoids that confers the red, blue and purple colours to plant-based foods such as berries, apples and blackcurrants, has been shown in epidemiological studies to be negatively correlated with CVD risk.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2010 journal article
Habitual intake of flavonoid subclasses and incident hypertension in adults--
The American Journal of Clinical Nutrition, 93(2), 338–347.
Source: ORCID
Added: November 13, 2019
2010 journal article
Pistachios increase serum antioxidants and lower serum oxidized-LDL in hypercholesterolemic adults
The Journal of Nutrition, 140(6), 1093–1098.
Source: ORCID
Added: November 13, 2019
2010 journal article
The future of flavonoid research
British Journal of Nutrition, 104(S3), S91–S95.
author keywords: Flavonoid; Bioactivity; Bioavailability; Metabolism
MeSH headings : Biological Availability; Biomedical Research; Diet; Flavonoids / metabolism; Flavonoids / pharmacology; Phenols / metabolism; Phenols / pharmacology; Polyphenols
TL;DR:
The following summarises the limitations of polyphenol research as described across various reviews throughout the literature and presents the key requirements for future research.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019
2009 journal article
Acute Fish Oil and Soy Isoflavone Supplementation Increase Postprandial Serum (n-3) Polyunsaturated Fatty Acids and Isoflavones but Do Not Affect Triacylglycerols or Biomarkers of Oxidative Stress in Overweight and Obese Hypertriglyceridemic Men
The Journal of Nutrition, 139(6), 1128–1134.
MeSH headings : Biomarkers; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Fatty Acids, Omega-3 / blood; Fish Oils / administration & dosage; Fish Oils / pharmacology; Humans; Hypertriglyceridemia / blood; Isoflavones / blood; Isoflavones / pharmacology; Male; Middle Aged; Overweight / blood; Oxidative Stress / physiology; Postprandial Period; Soybeans; Triglycerides / blood
TL;DR:
The current study adds to a limited literature on the acute effects of FO and ISO interventions on postprandial biomarkers of CVD risk by determining the effects of acutely supplementing a high-fat, high-fructose meal with fish oil and is oflavone placebo (FO) and fish oil placebo and soy isoflavones (ISO).
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2009 journal article
Anthocyanin Stability and Recovery: Implications for the Analysis of Clinical and Experimental Samples
Journal of Agricultural and Food Chemistry, 57(12), 5271–5278.
author keywords: Degradation; anthocyanin; phenolic acids; flavonoid; stability
MeSH headings : Anthocyanins / chemistry; Anthocyanins / metabolism; Humans; Models, Biological
TL;DR:
Data indicate that significant portions of ingested anthocyanins are likely to degrade to phenolic acids and aldehyde in vivo, and these compounds should be the target of future bioavailability and bioactivity studies to establish the true occurrence and impact of anthcyanins on human health.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019
2009 journal article
Cardiovascular disease risk biomarkers and liver and kidney function are not altered in postmenopausal women after ingesting an elderberry extract rich in anthocyanins for 12 weeks
The Journal of Nutrition, 139(12), 2266–2271.
Source: ORCID
Added: November 13, 2019
2009 journal article
Soy protein isoflavones, serum lipids and markers of oxidation and inflammation
Journal of Nutrition, 139, 1–7.
Source: NC State University Libraries
Added: March 26, 2021
2009 journal article
The bioactivity of dietary anthocyanins is likely to be mediated by their degradation products
Molecular Nutrition & Food Research, 53(S1), S92–S101.
author keywords: Anthocyanin; Degradation; Flavonoid; Metabolite; Phenolic
MeSH headings : Anthocyanins / administration & dosage; Anthocyanins / chemistry; Anthocyanins / metabolism; Biological Availability; Caco-2 Cells; Culture Media; Diet; Drug Stability; Glucosides / chemistry; Glucosides / metabolism; Humans; Hydrogen-Ion Concentration; Hydrolysis; Kinetics
TL;DR:
Data suggest a significant proportion of intestinal metabolites of anthocyanins are likely to be conjugates of their degradation products, including phenolic acid and aldehyde products of degradation, along with their respective metabolites.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019
2008 journal article
Bioactivity, absorption, and metabolism of anthocyanins
Recent Advances in Polyphenol Research, 1, 228–262.
Source: ORCID
Added: November 13, 2019
2008 journal article
Effects of pistachios on cardiovascular disease risk factors and potential mechanisms of action: a dose-response study--
The American Journal of Clinical Nutrition, 88(3), 651–659.
Source: ORCID
Added: November 13, 2019
2008 journal article
The major intestinal metabolites of anthocyanins are unlikely to be conjugates of their parent compounds but metabolites of their degradation products
Proceedings of the Nutrition Society, 67(OCE8).
TL;DR:
) does not appear achievable inhuman subjects and the in vitro mechanistic bioactivity of anthocyanins has been exclusively explored using aglycones andglycoside conjugates, despite a lack of evidence establishing these compounds as the biologically-available forms.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2007 chapter
Clinical Nutrition Studies
In Handbook of Nutrition and Food, Second Edition (pp. 693–714).
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, ORCID
Added: November 13, 2019
2007 conference paper
Effect of acute fish oil and soy isoflavone supplementation on postprandial serum triglycerides and biomarkers of oxidative stress in overweight or obese, hypertriglyeridemic men
The FASEB Journal, 21(5), A370.
Event: Federation of American Societies for Experimental Biology 2007
TL;DR:
The study meal significantly increased TG within all treatments but did not significantly affect any OXID biomarkers, and there were no significant differences between treatments for TG or OXIDs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: March 26, 2021
2007 journal article
Pistachios Reduce Blood Pressure and Vascular Responses to Acute Stress in Healthy Adults
The FASEB Journal, 21(5).
Sources: Crossref, NC State University Libraries
Added: September 3, 2020
2007 chapter
Pistachios beneficially affect multiple lipid and apolipoprotein CVD risk factors
In The FASEB Journal (Vol. 21, p. A695).
Event: Federation of American Societies for Experimental Biology Meeting
TL;DR:
There was a significant difference between the 1.5 oz PD and 3.0 PD diets, indicating that the pistachio‐rich diets improve lipids, lipoproteins, and apolipoproteins in a dose‐dependent manner.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: March 26, 2021
2007 article
Pistachios reduce serum oxidized LDL and increase serum antioxidant levels
Federation of American Societies for Experimental Biology.
Source: ORCID
Added: November 13, 2019
2006 journal article
Aspects of anthocyanin absorption, metabolism and pharmacokinetics in humans
Nutrition Research Reviews, 19(1), 137–146.
author keywords: anthocyanins; flavonoids; pharmacokinetics; metabolites
TL;DR:
The present review integrates the available anthocyanin literature with that of similar flavonoids or polyphenols in order to form hypotheses regarding absorption, metabolism and clearance in humans, and suggests that Anthocyanins are absorbed and transported in human serum and urine primarily as metabolites.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019
2006 journal article
Effects of antioxidant-rich foods on vascular reactivity: Review of the clinical evidence
Current Atherosclerosis Reports, 8(6), 510–522.
MeSH headings : Antioxidants / pharmacology; Cardiovascular Diseases / diet therapy; Cardiovascular Diseases / physiopathology; Food, Fortified; Humans; Prognosis; Vascular Resistance / drug effects
TL;DR:
The evidence presented herein suggests that dietary consumption of fruits and vegetables, red grapes and red wine, tea, chocolate, and olive oil may improve vascular reactivity, in part, by attenuating the adverse effects of oxidation on endothelial function.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019
2006 conference paper
Inflammatory status modifies the actions of n3 fatty acids on vascular function
The FASEB Journal, 20(4), A10.
Event: Federation of American Societies for Experimental Biology Meeting
TL;DR:
The specific effects of n3 fatty acids on vascular function appear to be dependent on background inflammatory status of individuals with type II diabetes.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: March 26, 2021
2005 chapter
Anthocyanins and Cancer Prevention
In Nutrition and Cancer Prevention.
Sources: Crossref, NC State University Libraries
Added: December 5, 2019
2005 journal article
Anthocyanins exist in the circulation primarily as metabolites in adult men
The Journal of Nutrition, 135(11), 2582–2588.
Source: ORCID
Added: November 13, 2019
2004 thesis
Analysis of the bioactivity, metabolism, and pharmacokinetics of anthocyanins in humans
(Thesis). University of Guelph, Guelph, Ont.
Source: NC State University Libraries
Added: March 29, 2021
2004 journal article
Anthocyanin metabolites in human urine and serum
British Journal of Nutrition, 91(6), 933–942.
author keywords: flavonoids; cyanidin 3-glycosides; glucurottide; methylated anthocyanins
MeSH headings : Adult; Anthocyanins / blood; Anthocyanins / metabolism; Anthocyanins / urine; Blueberry Plants; Chromatography, High Pressure Liquid / methods; Fruit / metabolism; Gas Chromatography-Mass Spectrometry / methods; Glucosides / blood; Glucosides / metabolism; Glucosides / urine; Humans; Hydrolysis; Male; Mass Spectrometry / methods; Middle Aged; Plant Extracts / administration & dosage; Plant Extracts / metabolism
TL;DR:
It is confirmed that human subjects have the capacity to metabolise cyanidin 3-glycosides, as at least ten individual anthocyanin metabolites in the urine and serum, and these metabolic products are likely in part responsible for the reported health benefits associated with the consumption of Anthocyanins.
(via Semantic Scholar)
Sources: Crossref, Web Of Science, ORCID
Added: November 13, 2019
2004 journal article
Methods of analysis for anthocyanins in plants and biological fluids
Journal of AOAC International, 87(1), 129–145.
Source: ORCID
Added: November 13, 2019
2003 conference paper
Anthocyanins Absorption and Serum Antioxidant Status in Humans
The 12th World Food Congress.
Source: NC State University Libraries
Added: March 29, 2021
2003 journal article
The postprandial effects of dietary antioxidants in humans
Current Atherosclerosis Reports, 5(6), 452.
Source: ORCID
Added: November 13, 2019
2002 journal article
Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects
Journal of Agricultural and Food Chemistry, 50(26), 7731–7737.
Source: ORCID
Added: November 13, 2019
2002 thesis
Assessment of the in Vivo Antioxidant Potential of Wild Blueberries in Humans
(Thesis). University of Guelph, Guelph, Ont.
Source: NC State University Libraries
Added: March 29, 2021
2002 journal article
The effect of wild blueberry (Vaccinium angustifolium) consumption on postprandial serum antioxidant status in human subjects
British Journal of Nutrition, 88(4), 389–397.
Source: ORCID
Added: November 13, 2019
2000 journal article
Activity and concentration of polyphenolic antioxidants in apple: Effect of cultivar, harvest year and storage condition.
Pakistan Journal of Biological Sciences, 11(12), 1056–1067.
Source: ORCID
Added: November 13, 2019
1991 report
Agroindustria rural en Venezuela
Quito, Ecuador: Instituto Latinoamericano de Fomento Agroindustrial.
Source: NC State University Libraries
Added: March 29, 2021
Employment
Updated: February 20th, 2024 11:06
2022 - present
University of Arkansas for Medical Sciences Little Rock, US
Professor
Pediatrics
Education
Updated: October 1st, 2018 11:55
1995 - present
University of Guelph Guelph, ON, CA
PhD
Nutrition
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