Colin David Kay

Gut microbes modulate the effects of the flavonoid quercetin on atherosclerosis

Npj Biofilms and Microbiomes.

Polyphenol metabolites in human milk: Potential role in support of healthy infant development, a narrative review

Fiecke, C., Knox, N., Andres, A., Ferruzzi, M. G., & Kay, C. (2025, February 5).

Chronic and postprandial effect of blueberries on cognitive function, alertness, and mood in participants with metabolic syndrome - results from a six-month, double-blind, randomized controlled trial

AMERICAN JOURNAL OF CLINICAL NUTRITION, 119(3), 658–668.

Genotype and ripening method affect carotenoid content and bio-accessibility in banana

Munoz, B., Hayes, M., Perkins-Veazie, P., Gillitt, N., Munoz, M., Kay, C. D., … Iorizzo, M. (2024, March 4). FOOD & FUNCTION, Vol. 3.

The high-fat diet and low-dose streptozotocin type-2 diabetes model induces hyperinsulinemia and insulin resistance in male but not female C57BL/6J mice

Nutrition Research, 131, 135–146.

A combined DHA-rich fish oil and cocoa flavanols intervention does not improve cognition or brain structure in older adults with memory complaints: results from the CANN randomized, controlled parallel-design study

AMERICAN JOURNAL OF CLINICAL NUTRITION, 118(2), 369–381.

Almond intake alters the acute plasma dihydroxy-octadecenoic acid (DiHOME) response to eccentric exercise

FRONTIERS IN NUTRITION, 9.

Bioavailable Microbial Metabolites of Flavanols Demonstrate Highly Individualized Bioactivity on In Vitro & beta;-Cell Functions Critical for Metabolic Health

Bioavailable Microbial Metabolites of Flavanols Demonstrate Highly Individualized Bioactivity on In Vitro & beta;-Cell Functions Critical for Metabolic Health. METABOLITES, 13(7).

Performance of Urinary Phenyl-γ-Valerolactones as Biomarkers of Dietary Flavan-3-ol Exposure

JOURNAL OF NUTRITION, 153(8), 2193–2204.

A randomized placebo-controlled cross-over study on the effects of anthocyanins on inflammatory and metabolic responses to a high-fat meal in healthy subjects

REDOX BIOLOGY, 51.

Blueberry anthocyanin intake attenuates the postprandial cardiometabolic effect of an energy-dense food challenge: Results from a double blind, randomized controlled trial in metabolic syndrome participants

CLINICAL NUTRITION, 41(1), 165–176.

Boosting the Bioaccessibility of Dietary Bioactives by Delivery as Protein-Polyphenol Aggregate Particles

Lila, M. A., Hoskin, R. T., Grace, M. H., Xiong, J., Strauch, R., Ferruzzi, M., … Kay, C. (2022, April 8). JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, Vol. 4.

Cocoa Extract Exerts Sex-Specific Effects in an Aggressive Hyper-Glycemia Model: A Pilot Study

Racine, K. C., Iglesias-Carres, L., Herring, J. A., Ferruzzi, M. G., Kay, C. D., Tessem, J. S., & Neilson, A. P. (2022, January 31). (Vol. 1). Vol. 1.

Cocoa extract exerts sex-specific anti-diabetic effects in an aggressive type-2 diabetes model: A pilot study

Biochemical and Biophysical Research Communications, 626, 205–210.

Effect of Wild Blueberry Metabolites on Biomarkers of Gastrointestinal and Immune Health In Vitro

Immuno, 2(2), 293–306.

Exploring the Contribution of (Poly)phenols to the Dietary Exposome Using High Resolution Mass Spectrometry Untargeted Metabolomics

Li, Y.-Y., Rushing, B., Schroder, M., Sumner, S., & Kay, C. D. (2022, February 25). MOLECULAR NUTRITION & FOOD RESEARCH, Vol. 2.

Foaming and sensory characteristics of protein-polyphenol particles in a food matrix

Food Hydrocolloids.

Spray-dried and freeze-dried protein-spinach particles; effect of drying technique and protein type on the bioaccessibility of carotenoids, chlorophylls, and phenolics

FOOD CHEMISTRY, 388.

The berry health tool chest - an evidence map and interactive resource

[Review of ]. NUTRITION REVIEWS, 80(1), 68–77.

An enriched biosignature of gut microbiota-dependent metabolites characterizes maternal plasma in a mouse model of fetal alcohol spectrum disorder

Scientific Reports, 11(1).

Cocoa Extract Exerts Sex-Specific Effects in an Aggressive Hyper-Glycemia Model: A Pilot Study

Racine, K. C., Iglesias-Carres, L., Herring, J. A., Ferruzzi, M. G., Kay, C. D., Tessem, J. S., & Neilson, A. P. (2021, December 7). (Vol. 12). Vol. 12.

High-density linkage map construction and identification of loci regulating fruit quality traits in blueberry

HORTICULTURE RESEARCH, 8(1).

Influence of simulated food and oral processing on carotenoid and chlorophyll in vitro bioaccessibility among six spinach genotypes

Hayes, M., Corbin, S., Nunn, C., Pottorff, M., Kay, C. D., Lila, M. A., … Ferruzzi, M. G. (2021, May 14). FOOD & FUNCTION, Vol. 5.

Microbial Metabolites of Flavanols in Urine are Associated with Enhanced Anti-Proliferative Activity in Bladder Cancer Cells In Vitro

Nutrition and Cancer, 74(1), 194–210.

Strawberry Consumption, Cardiometabolic Risk Factors, and Vascular Function: A Randomized Controlled Trial in Adults with Moderate Hypercholesterolemia

JOURNAL OF NUTRITION, 151(6), 1517–1526.

Blueberry and/or Banana Consumption Mitigate Arachidonic, Cytochrome P450 Oxylipin Generation During Recovery From 75-Km Cycling: A Randomized Trial

FRONTIERS IN NUTRITION, 7.

Development of a genetic framework to improve the efficiency of bioactive delivery from blueberry

SCIENTIFIC REPORTS, 10(1).

In Vitro Bioaccessibility of Carotenoids and Chlorophylls in a Diverse Collection of Spinach Accessions and Commercial Cultivars

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 68(11), 3495–3505.

Recommendations for standardizing nomenclature for dietary (poly)phenol catabolites

AMERICAN JOURNAL OF CLINICAL NUTRITION, 112(4), 1051–1068.

Supplemental treatment options for diabetes: how flavanol metabolites improve beta-cell function

Lloyd, T., Griffin, L., Krueger, E., Beales, J., Barlow, A., Sheets, J., … Tessem, J. (2020, April). FASEB JOURNAL, Vol. 34.

Terms and nomenclature used for plant-derived components in nutrition and related research: efforts toward harmonization

[Review of ]. NUTRITION REVIEWS, 78(6), 451–458.

Adaptation of an in Vitro Digestion Model for High Throughput Phenolic Bioaccessibility Phenotyping Within Cultivated (highbush) Blueberry Varieties (P06-004-19)

Current Developments in Nutrition, 3(Supplement 1).

Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome—results from a 6-month, double-blind, randomized controlled trial

The American Journal of Clinical Nutrition, 109(6), 1535–1545.

Contribution of Berry Polyphenols to the Human Metabolome

Molecules.

Diversity in the Bioaccessibility of Carotenoid and Chlorophyll Compounds in 69 Spinach Genotypes (P06-007-19)

Current Developments in Nutrition, 3(Supplement 1).

Managing Risks Associated with Establishing the Metabolome of Dietary Phytochemicals (P06-010-19)

Current Developments in Nutrition, 3(Supplement 1).

Cardiovascular Mechanisms of Action of Anthocyanins May Be Associated with the Impact of Microbial Metabolites on Heme Oxygenase-1 in Vascular Smooth Muscle Cells

Molecules, 23(4), 898.

Effect of adding milk to black tea on vascular function in healthy men and women: a randomised controlled crossover trial

Food & Function, 9(12), 6307–6314.

Increased Plasma Levels of Gut-Derived Phenolics Linked to Walking and Running Following 2-Weeks Flavonoid Supplementation

Nieman, D. C., Kay, C. D., Rathore, A. S., Grace, M. H., Strauch, R. C., Stephan, E. H., … Lila, M. A. (2018, October 15). (Vol. 10). Vol. 10.

Increased Plasma Levels of Gut-Derived Phenolics Linked to Walking and Running Following Two Weeks of Flavonoid Supplementation

Nutrients, 10(11).

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

Comprehensive Reviews in Food Science and Food Safety, 17(5), 1054–1112.

Anthocyanins and Flavanones Are More Bioavailable than Previously Perceived: A Review of Recent Evidence

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 8, Vol. 8, pp. 155–180.

Influence of Ingesting a Flavonoid-Rich Supplement On the Human Metabolome and Concentration of Urine Phenolics

The FASEB Journal, 31(Supplement 1), 972.26.

Influence of Ingesting a Flavonoid-Rich Supplement on the Metabolome and Concentration of Urine Phenolics in Overweight/Obese Women

JOURNAL OF PROTEOME RESEARCH, 16(8), 2924–2935.

Signatures of anthocyanin metabolites identified in humans inhibit biomarkers of vascular inflammation in human endothelial cells

Molecular Nutrition & Food Research, 61(9).

Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trial, 2

The American Journal of Clinical Nutrition, 103(3), 694–702.

Common Phenolic Metabolites of Flavonoids, but Not Their Unmetabolized Precursors, Reduce the Secretion of Vascular Cellular Adhesion Molecules by Human Endothelial Cells--3

The Journal of Nutrition, 146(3), 465–473.

Elucidating metabolic signatures of phytochemical consumption

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 252.

Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells

Molecular Nutrition & Food Research, 59(6), 1095–1106.

Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells

Molecular Nutrition & Food Research, 59(6), 1095–1106.

Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes

Molecular Nutrition & Food Research, 59(6), 1143–1154.

Orange juice--derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease--

The American Journal of Clinical Nutrition, 101(5), 931–938.

Phenolic Metabolites of Anthocyanins Modulate Mechanisms of Endothelial Function

Journal of Agricultural and Food Chemistry, 63(9), 2423–2431.

Rethinking paradigms for studying mechanisms of action of plant bioactives

Nutrition Bulletin, 40(4), 335–339.

Sulfurophane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo

International Journal of Experimental Pathology, 96(2), A24.

The bioactivity of flavonoids is likely the result of cumulative low exposure to a variety of structurally similar phenolic metabolites

The FASEB Journal, 29(Supplement 1), 118.4.

A moderate-fat diet containing pistachios improves emerging markers of cardiometabolic syndrome in healthy adults with elevated LDL levels

British Journal of Nutrition, 112(5), 744–752.

Methods for Isolating, Identifying, and Quantifying Anthocyanin Metabolites in Clinical Samples

Analytical Chemistry, 86(20), 10052–10058.

Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo

Osteoarthritis and Cartilage, 22, S322–S323.

The pharmacokinetics of anthocyanins and their metabolites in humans

British Journal of Pharmacology, 171(13), 3268–3282.

A moderate-fat diet with pistachios lowers small-dense LDL and improves markers of insulin sensitivity in subjects with moderately-elevated cholesterol Levels

Federation of American Societies for Experimental Biology.

Absorption, distribution, metabolism and elimination of a stable isotope-labelled anthocyanin in humans

FASEB Journal, 27(Supplement 1), 125.6.

Encyclopedia of Human Nutrition: Phytochemicals: Classification and Occurrence

Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a 13C-tracer study--

The American of Clinical Nutrition, 97(5), 995–1003.

Metabolism of dietary flavonoids alters their effect on tumor necrosis factor-α

Cytokine, 63(3), 259.

Phenolic metabolites of anthocyanins following a dietary intervention study in post-menopausal women

Molecular Nutrition & Food Research, 58(3), 490–502.

Potential Health Benefits of Blackcurrants

In M. Skinner & D. Hunter (Eds.), Bioactives in Fruit (pp. 215–250).

Sulforaphane Represses Matrix-Degrading Proteases and Protects Cartilage From Destruction In Vitro and In Vivo

Arthritis & Rheumatism, 65(12), 3130–3140.

Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo

Osteoarthritis and Cartilage, 21, S217–S218.

The metabolic fate of anthocyanins in humans

FASEB Journal, 27(Supplement 1), 125.7.

Vascular bioactivity of anthocyanin degradants: inhibition of endothelial superoxide production

Proceedings of the Nutrition Society, 72(OCE4).

Dietary Flavonoids and Risk of Stroke in Women

Stroke, 43(4), 946–951.

Dietary flavonoids and risk of stroke in women

Stroke, STROKEAHA-111.

Diets Containing Pistachios Reduce Systolic Blood Pressure and Peripheral Vascular Responses to Stress in Adults With Dyslipidemia

Hypertension, 60(1), 58–63.

Effect of cyanidin-glucoside and its metabolites on inflammatory biomarkers of vascular function

Proceedings of the Nutrition Society, 71(OCE2).

Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials--

The American Journal of Clinical Nutrition, 95(3), 740–751.

Effects of pistachios and walnuts on hemodynamic reactivity to stress: Clinical trials in adults with dyslipidemia

Australasian Medical Journal (Online, 5(12), 676.

Flavonoid metabolism: the synthesis of phenolic glucuronides and sulfates as candidate metabolites for bioactivity studies of dietary flavonoids

Tetrahedron, 68(22), 4194–4201.

Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women--

The American Journal of Clinical Nutrition, 96(4), 781–788.

Investigating the bioavailability of anthocyanin metabolites

Proceedings of the Nutrition Society, 71(OCE2).

Relative impact of flavonoid composition, dose and structure on vascular function: A systematic review of randomised controlled trials of flavonoid-rich food products

Molecular Nutrition & Food Research, 56(11), 1605–1616.

Relative impact of flavonoid composition, dose and structure on vascular function: a systematic review of randomised controlled trials of flavonoid-rich food products

Molecular Nutrition & Food Research, 56(11), 1605–1616.

Synthesis of [6, 8, 10, 3’, 5’-C-13 (5)]-cyanidin-3-glucoside, for human in vivo metabolism studies

Journal of Labelled Compounds & Radiopharmaceuticals, 55(3), 131–132.

The impact of human metabolism on the bioactivity of anthocyanins

Proceedings of the Nutrition Society, 71(OCE2).

Vascular bioactivity of anthocyanins and phenolic acid degradants: modulation of superoxide and nitric oxide

Proceedings of the Nutrition Society, 71(OCE2).

A gram scale synthesis of a multi-13 C-labelled anthocyanin,[6, 8, 10, 3′, 5′-13 C 5] cyanidin-3-glucoside, for use in oral tracer studies in humans

Chemical Communications, 47(38), 10596–10598.

A gram scale synthesis of a multi-13C-labelled anthocyanin, [6,8,10,3′,5′-13C5]cyanidin-3-glucoside, for use in oral tracer studies in humans

Chemical Communications, 47(38), 10596.

A potential mechanism of action of dietary anthocyanins: modulation of endothelial superoxide production by phenolic acid metabolites

Proceedings of the Nutrition Society, 70(OCE4).

Anthocyanin-derived phenolic acids form glucuronides following simulated gastrointestinal digestion and microsomal glucuronidation

Molecular Nutrition & Food Research, 55(3), 378–386.

Anthocyanins Remain Stable during Commercial Blackcurrant Juice Processing

Journal of Food Science, 76(6), S408–S414.

Effects of pistachios on emerging CVD risk factors in moderately hypercholesterolemic individuals

The FASEB Journal, 25(S1), 971.21.

Effects of sugar-sweetened and sugar-free cocoa on endothelial function in overweight adults

International Journal of Cardiology, 149(1), 83–88.