Courtney Klotz

Works (5)

Updated: July 5th, 2023 15:35

2020 journal article

Deletion of S-Layer Associated Ig-Like Domain Protein Disrupts the Lactobacillus acidophilus Cell Surface

FRONTIERS IN MICROBIOLOGY, 11.

By: C. Klotz n, Y. Goh n, S. O'Flaherty n, B. Johnson n & R. Barrangou n 

author keywords: Lactobacillus; probiotic; S-layer; cell surface; S-layer associated protein; Ig-like domain
TL;DR: Identification of similar proteins in alternative bacterial species may help pinpoint next-generation host-adapted probiotic candidates. (via Semantic Scholar)
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15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 27, 2020

2019 article

CRISPR Cinema: Scenes from the Cutting Edge

Klotz, C. (2019, April). CRISPR JOURNAL, Vol. 2, pp. 76–78.

By: C. Klotz n

MeSH headings : CRISPR-Cas Systems / genetics; Clustered Regularly Interspaced Short Palindromic Repeats / genetics; Genetic Engineering / ethics; Humans; Motion Pictures
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Source: Web Of Science
Added: May 20, 2019

2018 review

Engineering Components of the Lactobacillus S-Layer for Biotherapeutic Applications

[Review of ]. FRONTIERS IN MICROBIOLOGY, 9.

By: C. Klotz n & R. Barrangou n 

author keywords: Lactobacillus; probiotic; S-layer; biotherapeutic; mucosal vaccine; CRISPR
TL;DR: The multi-faceted S-layer protein (Slp), and its use in both heterologous protein expression systems and mucosal vaccine delivery frameworks, is examined, through its diverse genetic components. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 16, 2018

2017 journal article

Alterations to metabolically active bacteria in the mucosa of the small intestine predict anti-obesity and anti-diabetic activities of grape seed extract in mice

Food & Function, 8(10), 3510–3522.

By: L. Griffin *, K. Witrick *, C. Klotz*, M. Dorenkott*, K. Goodrich*, G. Fundaro*, R. McMillan *, M. Hulver *, M. Ponder *, A. Neilson* 

MeSH headings : Animals; Bacteria / classification; Bacteria / genetics; Bacteria / isolation & purification; Blood Glucose / metabolism; Diabetes Mellitus / drug therapy; Diabetes Mellitus / metabolism; Diabetes Mellitus / microbiology; Diet, High-Fat / adverse effects; Gastrointestinal Microbiome / drug effects; Grape Seed Extract / administration & dosage; Humans; Insulin / metabolism; Intestine, Small / metabolism; Intestine, Small / microbiology; Male; Mice; Mice, Inbred C57BL; Obesity / drug therapy; Obesity / metabolism; Obesity / microbiology; Vitis / chemistry
TL;DR: Grape seed extract can prevent early changes in glucose tolerance and alter small intestinal gut microbiota, prior to the onset of skeletal muscle metabolic derangements, when grape seed extract is consumed at a low dose in the context of a moderately high fat diet. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

Investigating the Effect of Growth Phase on the Surface-Layer Associated Proteome of Lactobacillus acidophilus Using Quantitative Proteomics

FRONTIERS IN MICROBIOLOGY, 8.

By: C. Klotz n, S. O'Flaherty n, Y. Goh n & R. Barrangou n 

author keywords: Lactobacillus; probiotic; cell surface; S-layer; quantitative proteomics
TL;DR: This study establishes a framework for quantifying condition-dependent changes to cell surface proteins that can easily be applied to other S-layer forming bacteria. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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