Works (2)

Updated: August 14th, 2023 19:25

2008 review

Disrupted female reproductive physiology following neonatal exposure to phytoestrogens or estrogen specific ligands is associated with decreased GnRH activation and kisspeptin fiber density in the hypothalamus

[Review of ]. NEUROTOXICOLOGY, 29(6), 988–997.

By: H. Bateman n & H. Patisaul n

author keywords: Genistein; Equal; Soy; Isoflavones; Gonadotropin; Puberty; Development; Endocrine disruption; DPN; PPT
MeSH headings : Analysis of Variance; Animals; Animals, Newborn; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrous Cycle / drug effects; Female; Gonadotropin-Releasing Hormone / metabolism; Hypothalamus / drug effects; Kisspeptins; Nerve Fibers / metabolism; Phenols / pharmacology; Proteins / metabolism; Pyrazoles / pharmacology; Rats; Receptors, Estrogen / agonists; Reproductive Physiological Phenomena / drug effects
TL;DR: The data suggest that neonatal exposure to EDCs can suppress GnRH activity in adulthood, and that ERalpha plays a pivotal role in this process. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 journal article

Neonatal exposure to endocrine active compounds or an ERβ agonist increases adult anxiety and aggression in gonadally intact male rats

Hormones and Behavior, 53(4), 580–588.

By: H. Patisaul n & H. Bateman n

author keywords: DPN; PPT; bisphenol; equol; estrogen; phytoestrogens; soy isoflavones; EAC; endocrine disruptors
MeSH headings : Age Factors; Aggression / drug effects; Aggression / physiology; Analysis of Variance; Animals; Animals, Newborn; Anxiety / metabolism; Benzhydryl Compounds; Endocrine Disruptors / pharmacology; Equol; Estrogen Receptor alpha / agonists; Estrogen Receptor alpha / metabolism; Estrogen Receptor beta / agonists; Estrogen Receptor beta / drug effects; Estrogen Receptor beta / metabolism; Isoflavones / pharmacology; Male; Nitriles / pharmacology; Phenols / pharmacology; Propionates / pharmacology; Pyrazoles / pharmacology; Rats; Rats, Long-Evans; Statistics, Nonparametric; Testis / drug effects; Testis / metabolism
TL;DR: It is suggested that neonatal exposure to EACs with agonistic activity on ERbeta may influence affective behavior in adulthood, including anxiety and aggression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

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