Caiti Heil

Also known as: Caiti Smukowski; Caiti Heil

Works (23)

Updated: April 3rd, 2024 19:44

2024 article

The recombination landscape of introgression in yeast

Schwarzkopf, E. J., Brandt, N., & Heil, C. S. (2024, January 5).

By: E. Schwarzkopf  n, N. Brandt n & C. Heil n 

TL;DR: The results indicate that recent hybridization can significantly influence the recombination landscape, and suggest that the reduction in allele shuffling contributes to the initial purging of introgressed ancestry in the generations following a hybridization event. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: February 2, 2024

2024 article

The recombination landscape of introgression in yeast

Schwarzkopf, E. J., Brandt, N., & Heil, C. S. (2024, March 15).

By: E. Schwarzkopf  n, N. Brandt  n & C. Heil n 

Source: ORCID
Added: March 22, 2024

2024 article

The recombination landscape of introgression in yeast

Schwarzkopf, E. J., Brandt, N., & Heil, C. S. (2024, March 15).

By: E. Schwarzkopf  n, N. Brandt n & C. Heil n 

Source: ORCID
Added: March 22, 2024

2023 article

Loss of Heterozygosity and Its Importance in Evolution

Heil, C. S. (2023, February 8). JOURNAL OF MOLECULAR EVOLUTION, Vol. 2.

By: C. Heil n 

author keywords: Loss of heterozygosity; Experimental evolution; Saccharomyces; Hybrids
TL;DR: Advances in understanding dominance, fitness, and phenotypes in laboratory evolved heterozygous yeast strains are highlighted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 9, 2023

2021 journal article

Sugar‐seeking insects as a source of diverse bread‐making yeasts with enhanced attributes

Yeast, 39(1-2), 108–127.

By: A. Madden n, C. Lahue n, C. Gordy n , J. Little n , L. Nichols n , M. Calvert  n, R. Dunn n , C. Smukowski Heil  n

author keywords: baking; bioprospecting; bread; Lachancea; non-conventional yeasts; Saccharomyces
MeSH headings : Animals; Bread; Fermentation; Insecta; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Sugars / metabolism; Yeasts
TL;DR: The results suggest that non‐conventional yeasts have high potential for baking and, more generally, showcase the success of bioprospecting in insects for identifying yeasts relevant for industrial uses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: November 17, 2021

2021 chapter

The Evolutionary History of Bread and Beer Yeast

In K. Dufresne (Ed.), Fermentology.

By: C. Heil n  & C. Lahue n

Ed(s): K. Dufresne 

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Crossref
Added: December 1, 2021

2020 article

Transposable element mobilization in interspecific yeast hybrids

Heil, C. S., Patterson, K., Hickey, A. S.-M., Alcantara, E., & Dunham, M. J. (2020, June 17). (Vol. 6). Vol. 6.

By: C. Heil n , K. Patterson *, A. Hickey *, E. Alcantara* & M. Dunham *

Source: ORCID
Added: June 19, 2020

2019 journal article

Fitness benefits of loss of heterozygosity in Saccharomyces hybrids

Genome Research, 29(10), 1685–1692.

By: S. Lancaster*, C. Payen*, C. Heil*  & M. Dunham *

MeSH headings : Genetic Fitness / genetics; Genetic Fitness / physiology; Genome, Fungal / genetics; Hybridization, Genetic / physiology; Loss of Heterozygosity / genetics; Saccharomyces / genetics; Saccharomyces / physiology; Saccharomyces cerevisiae / genetics
TL;DR: It is suggested that LOH can be a successful strategy for adaptation of hybrids to new environments, and candidate loci that drive the chromosomal rearrangements observed in evolution of yeast hybrids are identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (OpenAlex)
Source: ORCID
Added: September 24, 2019

2019 journal article

Temperature preference can bias parental genome retention during hybrid evolution

PLOS Genetics, 15(9), e1008383.

By: C. Heil* , C. Large *, K. Patterson *, A. Hickey *, C. Yeh * & M. Dunham *

Ed(s): C. Hittinger

MeSH headings : Adaptation, Biological / genetics; Adaptation, Physiological / genetics; Biological Evolution; Chimera / genetics; Cold Temperature; Genetic Fitness / genetics; Genetic Variation / genetics; Genome, Fungal / genetics; Genotype; Hybridization, Genetic / genetics; Proton-Phosphate Symporters / genetics; Proton-Phosphate Symporters / metabolism; Saccharomyces / genetics; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Temperature
TL;DR: How hybrid adaptation to temperature and nutrient limitation may alter parental genome representation over time is investigated, and a large contribution to this directionality is due to a temperature dependent fitness benefit at a single locus, the high affinity phosphate transporter gene PHO84. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (OpenAlex)
Source: ORCID
Added: September 17, 2019

2018 article

Fitness Benefits of Loss of Heterozygosity in Saccharomyces Hybrids

Lancaster, S. M., Payen, C., Heil, C. S., & Dunham, M. J. (2018, October 25). (Vol. 10). Vol. 10.

By: S. Lancaster*, C. Payen*, C. Heil*  & M. Dunham *

UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: September 12, 2019

2018 article

Temperature preference biases parental genome retention during hybrid evolution

Heil, C. S., Large, C. R. L., Patterson, K., & Dunham, M. J. (2018, September 27). (Vol. 9). Vol. 9.

By: C. Heil* , C. Large *, K. Patterson * & M. Dunham *

TL;DR: This work investigates how the environment, and more specifically temperature, interacts with hybrid genomes to alter parental genome representation over time, and shows that a large contribution to this directionality is due to temperature sensitivity at a single locus, the high affinity phosphate transporter PHO84. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: September 12, 2019

2017 journal article

Experimental Evolution Reveals Favored Adaptive Routes to Cell Aggregation in Yeast

Genetics, 206(2), 1153–1167.

By: E. Hope, C. Amorosi, A. Miller *, K. Dang, C. Heil*  & M. Dunham *

author keywords: flocculation; experimental evolution; yeast; chemostat; FLO1
MeSH headings : Cell Aggregation / genetics; DNA Transposable Elements / genetics; Directed Molecular Evolution; Flocculation; Genetics, Population; Mannose-Binding Lectins / genetics; Nuclear Proteins / genetics; Phenotype; Promoter Regions, Genetic; Repressor Proteins / genetics; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae Proteins / genetics; Sequence Deletion
TL;DR: Evolving a flo1 deletion strain revealed that this single deletion reduces flocculation occurrences to 3%, and demonstrated the efficacy of using experimental evolution as a tool to identify and eliminate the primary adaptive routes for undesirable traits. (via Semantic Scholar)
Source: ORCID
Added: September 12, 2019

2017 article

Identification of a novel interspecific hybrid yeast from a metagenomic spontaneously inoculated beer sample using Hi-C

Heil, C. S., Burton, J. N., Liachko, I., Friedrich, A., Hanson, N. A., Morris, C. L., … Dunham, M. J. (2017, June). (Vol. 6). Vol. 6.

By: C. Heil* , J. Burton *, I. Liachko, A. Friedrich *, N. Hanson, C. Morris, J. Schacherer *, J. Shendure *, J. Thomas, M. Dunham

UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: September 12, 2019

2017 journal article

Loss of Heterozygosity Drives Adaptation in Hybrid Yeast

Molecular Biology and Evolution, 34(7), 1596–1612.

By: C. Heil* , C. DeSevo*, D. Pai*, C. Tucker*, M. Hoang * & M. Dunham *

author keywords: hybrid; adaptation; loss of heterozygosity; experimental evolution; Saccharomyces uvarum; Saccharomyces cerevisiae
MeSH headings : Adaptation, Physiological / genetics; Biological Evolution; Genome / genetics; Hybridization, Genetic / genetics; Loss of Heterozygosity / genetics; Saccharomyces / genetics; Saccharomyces cerevisiae / genetics
TL;DR: This is an example where hybrid genome resolution is driven by positive selection on existing heterozygosity and demonstrates that even infrequent outcrossing may have lasting impacts on adaptation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: September 12, 2019

2016 article

Experimental evolution reveals favored adaptive routes to cell aggregation in yeast

(Vol. 12). Vol. 12.

By: E. Hope*, C. Amorosi*, A. Miller *, K. Dang*, C. Heil*  & M. Dunham *

Source: ORCID
Added: September 12, 2019

2015 journal article

Recombining without Hotspots: A Comprehensive Evolutionary Portrait of Recombination in Two Closely Related Species ofDrosophila

Genome Biology and Evolution, 7(10), 2829–2842.

By: C. Heil* , C. Ellison *, M. Dubin* & M. Noor *

author keywords: recombination; evolution; Drosophila; linkage disequilibrium; hotspots
MeSH headings : Animals; Base Sequence; Drosophila / enzymology; Drosophila / genetics; Evolution, Molecular; Genetic Variation; Genome; Histone-Lysine N-Methyltransferase / genetics; Humans; Linkage Disequilibrium; Male; Meiosis / genetics; Molecular Sequence Data; Pan troglodytes; Recombination, Genetic; Species Specificity
TL;DR: This study compares genome wide recombination rate in two closely related species of the fruit fly Drosophila to understand if and how recombination changes over time, and finds that recombination does indeed change and is dependent on the physical scale at which recombination is measured. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: September 12, 2019

2015 article

Recombining without hotspots: A comprehensive evolutionary portrait of recombination in two closely related species of Drosophila

Heil, C. S., Ellison, C., Dubin, M., & Noor, M. (2015, March). (Vol. 3). Vol. 3.

By: C. Heil* , C. Ellison *, M. Dubin* & M. Noor *

UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: September 12, 2019

2014 journal article

No Detectable Effect of the DNA Methyltransferase DNMT2 on Drosophila Meiotic Recombination

G3&Amp;#58; Genes|Genomes|Genetics, 4(11), 2095–2100.

By: C. Heil* 

author keywords: DNA methylation; DNMT2; recombination; Drosophila; epigenetics
MeSH headings : Animals; Chromatin / genetics; DNA (Cytosine-5-)-Methyltransferases / genetics; DNA (Cytosine-5-)-Methyltransferases / metabolism; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Epigenesis, Genetic; Meiosis; Recombination, Genetic
TL;DR: It is concluded that other epigenetic effects are regulating recombination initiation in Drosophila. (via Semantic Scholar)
Source: ORCID
Added: September 12, 2019

2012 journal article

Mentor vs. Monolith

American Scientist, 100(6), 450.

By: C. Heil*  & M. Noor

Source: ORCID
Added: September 12, 2019

2012 journal article

Recombination Modulates How Selection Affects Linked Sites in Drosophila

PLoS Biology, 10(11), e1001422.

By: S. McGaugh *, C. Heil* , B. Manzano-Winkler*, L. Loewe *, S. Goldstein*, T. Himmel*, M. Noor *

Ed(s): N. Barton

MeSH headings : Animals; Base Sequence; Chromosome Mapping; Chromosomes, Insect / genetics; Codon / genetics; Confidence Intervals; Conserved Sequence; Drosophila / genetics; Evolution, Molecular; Genetic Linkage; Genetic Variation; Genetics, Population / methods; Genome, Insect; Linear Models; Recombination, Genetic; Selection, Genetic; Species Specificity; Telomere / genetics
TL;DR: Recombination rate in Drosophila species shapes the impact of selection in the genome and is positively correlated with nucleotide diversity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: September 12, 2019

2012 journal article

Witnessing Phenotypic and Molecular Evolution in the Fruit Fly

Evolution: Education and Outreach, 5(4), 629–634.

By: C. Heil* , M. Hunter, J. Noor*, K. Miglia*, B. Manzano-Winkler*, S. McDermott*, M. Noor *

TL;DR: This multi-day exercise is designed for a college genetics and evolution laboratory to demonstrate concepts of inheritance and phenotypic and molecular evolution using a live model organism, Drosophila simulans, to track the spread of this advantageous trait over several generations. (via Semantic Scholar)
Source: ORCID
Added: September 12, 2019

2012 journal article

Zinc Finger Binding Motifs Do Not Explain Recombination Rate Variation within or between Species of Drosophila

PLoS ONE, 7(9), e45055.

By: C. Heil*  & M. Noor *

Ed(s): N. Singh

MeSH headings : Animals; Base Sequence; Drosophila / genetics; Drosophila Proteins / chemistry; Drosophila Proteins / metabolism; Humans; Mice; Models, Molecular; Molecular Sequence Data; Protein Binding / genetics; Recombination, Genetic; Reproducibility of Results; Sequence Homology, Amino Acid; Species Specificity; Zinc Fingers
TL;DR: It is concluded that there is no protein with a DNA sequence specific human-PRDM9-like function in Drosophila, and these findings could be explained by the existence of a different recombination initiation system in Dosophila. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: September 12, 2019

2011 journal article

Recombination rate variation in closely related species

Heredity, 107(6), 496–508.

By: C. Smukowski* & M. Noor *

author keywords: recombination rate; meiotic recombination; variation; genome evolution; conservation; divergence
MeSH headings : Animals; Eukaryota / genetics; Evolution, Molecular; Genome; Humans; Pan troglodytes / genetics; Recombination, Genetic; Selection, Genetic
TL;DR: This work evaluates how and why conflicting patterns of recombination rate conservation and divergence may be observed, with particular emphasis on features that affect recombination, and the scale and method with which recombination is surveyed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: September 12, 2019

Employment

Updated: September 12th, 2019 15:20

2019 - present

North Carolina State University Raleigh, NC, US
Assistant Professor Biological Sciences

2014 - 2018

University of Washington Seattle, WA, US
Senior Fellow Genome Sciences

Education

Updated: September 12th, 2019 15:23

2009 - 2014

Duke University Durham, NC, US
PhD Biology

2005 - 2009

University of Pennsylvania Philadelphia, PA, US
B.A. in Biology

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