Works (10)

Updated: July 5th, 2023 15:35

2021 journal article

Comparative Genomic Analyses and CRISPR-Cas Characterization of Cutibacterium acnes Provide Insights Into Genetic Diversity and Typing Applications


By: N. Cobian n, A. Garlet*, C. Hidalgo-Cantabrana n & R. Barrangou n

author keywords: CRISPR; genomics; Cas; genotyping; phylogeny
TL;DR: A comprehensive comparative analysis of 255 C. acnes genomes is presented to provide insights into the species genetic diversity and identify unique features that define various phylotypes, opening new avenues for the development of biotherapeutics to manipulate the skin microbiota. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: November 29, 2021

2020 journal article

Comparative Analysis of Lactobacillus gasseri and Lactobacillus crispatus Isolated From Human Urogenital and Gastrointestinal Tracts


author keywords: probiotics; niche-specific adaptation; Lactobacillus; women's health; in vitro vaginal fluid model
Sources: Web Of Science, NC State University Libraries
Added: February 17, 2020

2019 review

Characterization and Repurposing of Type I and Type II CRISPR-Cas Systems in Bacteria

[Review of ]. JOURNAL OF MOLECULAR BIOLOGY, 431(1), 21–33.

author keywords: CRISPR-Cas systems; CRISPR characterization; endogenous systems; genome editing
TL;DR: There is a wide diversity of native CRISPR-Cas systems in many bacteria and most archaea that await functional characterization and repurposing for genome editing applications in prokaryotes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 11, 2019

2019 journal article

Filling the gap between collection, transport and storage of the human gut microbiota


MeSH headings : Adult; Akkermansia; Anaerobiosis; Bacteria / isolation & purification; Clostridiales / isolation & purification; Faecalibacterium prausnitzii / isolation & purification; Feces / microbiology; Female; Gastrointestinal Microbiome; Humans; Male; Middle Aged; Oxygen / metabolism; RNA, Ribosomal, 16S / genetics; Specimen Handling / methods; Verrucomicrobia / isolation & purification
TL;DR: Evidence is presented that keeping anaerobiosis has a deep impact on the viability and diversity of the fecal microbiota that is recovered in the laboratory and the use of GutAlive for stool collection and transport optimized the viability of EOS bacteria in the lab by diminishing oxygen toxicity. (via Semantic Scholar)
Source: Web Of Science
Added: June 24, 2019

2019 journal article

Gut microbiota dysbiosis in a cohort of patients with psoriasis


By: C. Hidalgo-Cantabrana*, J. Gomez*, S. Delgado*, S. Requena-Lopez*, R. Queiro-Silva, A. Margolles*, E. Coto*, B. Sanchez*, P. Coto-Segura*

MeSH headings : Adult; Cohort Studies; DNA, Bacterial / isolation & purification; Dysbiosis / complications; Dysbiosis / diagnosis; Dysbiosis / immunology; Dysbiosis / microbiology; Feces / microbiology; Female; Gastrointestinal Microbiome / genetics; Gastrointestinal Microbiome / immunology; Healthy Volunteers; Humans; Male; Middle Aged; Psoriasis / immunology; Psoriasis / microbiology; RNA, Ribosomal, 16S / genetics
TL;DR: There is increasing evidence of the key role that the gut microbiota plays in inflammatory diseases and the importance of knowing your gut microbiota to understand and treat inflammatory diseases is increasing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: December 30, 2019

2018 review

Insights into the Human Virome Using CRISPR Spacers from Microbiomes

[Review of ]. VIRUSES-BASEL, 10(9).

author keywords: CRISPR-Cas systems; CRISPR spacers; virome; phages; microbiome
MeSH headings : Biodiversity; Clustered Regularly Interspaced Short Palindromic Repeats; Humans; Metagenomics; Microbiota; Viruses / classification; Viruses / genetics; Viruses / isolation & purification
TL;DR: It is shown how the CRISPR spacer content of commensal and pathogenic bacteria can be used to determine the evidence of their phage exposure, which opens new opportunities for investigating host-virus dynamics in metagenomic data, and highlights the need for more efforts for virome sampling and sequencing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 26, 2018

2018 journal article

Transcriptional and Functional Analysis of Bifidobacterium animalis subsp. lactis Exposure to Tetracycline


Ed(s): V. Müller

author keywords: Bifidobacterium animalis subsp. lactis; antibiotic resistance; tetracycline; RNA sequencing; genomics; droplet digital PCR; ATP luminescence
MeSH headings : Anti-Bacterial Agents / pharmacology; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Bifidobacterium animalis / drug effects; Bifidobacterium animalis / genetics; Bifidobacterium animalis / metabolism; Clustered Regularly Interspaced Short Palindromic Repeats / drug effects; Gene Expression Regulation, Bacterial / drug effects; Genome, Bacterial / drug effects; Tetracycline / pharmacology; Tetracycline Resistance; Transcription, Genetic / drug effects
TL;DR: The results provide high-throughput means for assessing antibiotic resistances of two highly related probiotic strains and determine the genetic network that contributes to the global tetracycline response. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 3, 2018

2018 journal article

Whole fractions from probiotic bacteria induce in vitro Th17 responses in human peripheral blood mononuclear cells


By: C. Hidalgo-Cantabrana*, M. Rosa Lucena-Prieto*, M. Antonio Moro-Garcia*, R. Alonso-Arias* & B. Sanchez*

author keywords: Bacterial fractions; Cytokine multiplex; DNA; Probiotics; Th17 response
TL;DR: Overall, the bacterial fractions elicited a different immune response in PBMCs, whereas the isolated DNA was able to induce a higher Th17-like response that could lead to a protective effect in the epithelial barrier function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: November 5, 2018

2017 review

CRISPR-based engineering of next-generation lactic acid bacteria


MeSH headings : Bifidobacterium / genetics; Bifidobacterium / physiology; CRISPR-Cas Systems; Food Microbiology / methods; Gene Editing; Humans; Lactobacillus / genetics; Lactobacillus / physiology; Metabolic Engineering; Probiotics
TL;DR: The advent of CRISPR-based technologies has opened new avenues for the development of next-generation food microorganisms and probiotics with enhanced functionalities and can be harnessed to genetically modify probiotics and enhance their therapeutic potential to deliver vaccines or modulate the host immune response. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

Characterization and Exploitation of CRISPR Loci in Bifidobacterium longum


author keywords: CRISPR-Cas systems; genotyping; probiotics; Bifidobacterium longum
TL;DR: It is suggested that CRISPR-Cas immune systems are instrumental in mounting diversified viral resistance in B. longum, and hypervariable loci can be used to gain insights into strain origin, evolution and phylogeny, and can provide discriminatory sequences to distinguish even clonal isolates. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

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