@article{jin_liao_wang_shen_jiang_zhang_wei_ghiladi_2022, title={Dual-functionalized luminescent/photodynamic composite fabrics: Synergistic antibacterial activity for self-disinfecting textiles}, volume={587}, ISSN={["1873-5584"]}, DOI={10.1016/j.apsusc.2022.152737}, abstractNote={For the purpose of developing self-disinfecting photodynamic textiles with enhanced antibacterial activity, here we report a scalable and facile method to immobilize the long persistent phosphor SrAl2O4:Eu2+, Dy3+ (SAOED) and the photosensitizer Rose Bengal onto cotton fabric (CF) by knife coating and photocrosslinking methods. The resultant composite material, termed SAOED/RB-CF, exhibited superior synergistic antibacterial efficacy capable of 99.999% (5 log units, detection limit) and 99.986% (3.9 log units) photoinactivation against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA), respectively, under visible-light illumination (Xenon lamp). Mechanistic studies employing both substrate photooxidation and EPR spin-trapping methods demonstrated an enhanced yield of singlet oxygen (1O2) production compared to the RB/CF material alone (without the phosphor), suggesting that the light emitted from the phosphorescence of the photoexcited SAOED could be absorbed by the RB photosensitizer under dark conditions, resulting in effective synergistic pathogen inactivation. In addition, the SAOED/RB-CF composite fabric possessed excellent abrasion resistance, mechanical strength and color fastness. Our findings suggest that the integration of long persistent phosphors into photodynamic materials may provide a new avenue to explore for developing composite fabrics as applied materials in infection control applications for use in both healthcare environments and consumer textiles.}, journal={APPLIED SURFACE SCIENCE}, author={Jin, Fangyu and Liao, Shiqin and Wang, Qingqing and Shen, Huiying and Jiang, Chenyu and Zhang, Jiawen and Wei, Qufu and Ghiladi, Reza A.}, year={2022}, month={Jun} }
 @article{shen_liao_jiang_zhang_wei_ghiladi_wang_2022, title={In situ grown bacterial cellulose/MoS2 composites for multi-contaminant wastewater treatment and bacteria inactivation}, volume={277}, ISSN={["1879-1344"]}, DOI={10.1016/j.carbpol.2021.118853}, abstractNote={For the purpose of developing multifunctional water purification materials capable of degrading organic pollutants while simultaneously inactivating microorganisms from contaminated wastewater streams, we report here a facile and eco-friendly method to immobilize molybdenum disulfide into bacterial cellulose via a one-step in-situ biosynthetic method. The resultant nanocomposite, termed BC/MoS2, was shown to possess a photocatalytic activity capable of generating •OH from H2O2, while also exhibiting photodynamic/photothermal mechanisms, the combination of which exhibits synergistic activity for the degradation of pollutants as well as for bacterial inactivation. In the presence of H2O2, the BC/MoS2 nanocomposite exhibited excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus upon infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min). Mechanistic studies revealed synergistic pathogen inactivation resulting from the combination of photocatalytically generated •OH and hyperthermia induced by the photothermal conversion of the near-IR light. In addition, the BC/MoS2 nanocomposite also showed excellent photodegradation activity for common aqueous contaminants in the presence of H2O2, including malachite green (a textile dye), catechol violet (a phenol) and formaldehyde. Taken together, our findings demonstrate that sustainable materials such as BC/MoS2 have potential applications in wastewater treatment and microorganism disinfection.}, journal={CARBOHYDRATE POLYMERS}, author={Shen, Huiying and Liao, Shiqin and Jiang, Chenyu and Zhang, Jiawen and Wei, Qufu and Ghiladi, Reza A. and Wang, Qingqing}, year={2022}, month={Feb} }
 @article{shen_ke_feng_jiang_wei_wang_2021, title={Highly Sensitive and Stretchable c-MWCNTs/PPy Embedded Multidirectional Strain Sensor Based on Double Elastic Fabric for Human Motion Detection}, volume={11}, ISSN={["2079-4991"]}, DOI={10.3390/nano11092333}, abstractNote={Owing to the multi-dimensional complexity of human motions, traditional uniaxial strain sensors lack the accuracy in monitoring dynamic body motions working in different directions, thus multidirectional strain sensors with excellent electromechanical performance are urgently in need. Towards this goal, in this work, a stretchable biaxial strain sensor based on double elastic fabric (DEF) was developed by incorporating carboxylic multi-walled carbon nanotubes(c-MWCNTs) and polypyrrole (PPy) into fabric through simple, scalable soaking and adsorption-oxidizing methods. The fabricated DEF/c-MWCNTs/PPy strain sensor exhibited outstanding anisotropic strain sensing performance, including relatively high sensitivity with the maximum gauge factor (GF) of 5.2, good stretchability of over 80%, fast response time < 100 ms, favorable electromechanical stability, and durability for over 800 stretching–releasing cycles. Moreover, applications of DEF/c-MWCNTs/PPy strain sensor for wearable devices were also reported, which were used for detecting human subtle motions and dynamic large-scale motions. The unconventional applications of DEF/c-MWCNTs/PPy strain sensor were also demonstrated by monitoring complex multi-degrees-of-freedom synovial joint motions of human body, such as neck and shoulder movements, suggesting that such materials showed a great potential to be applied in wearable electronics and personal healthcare monitoring.}, number={9}, journal={NANOMATERIALS}, author={Shen, Huiying and Ke, Huizhen and Feng, Jingdong and Jiang, Chenyu and Wei, Qufu and Wang, Qingqing}, year={2021}, month={Sep} }
 @article{shen_jiang_li_wei_ghiladi_wang_2021, title={Synergistic Photodynamic and Photothermal Antibacterial Activity of In Situ Grown Bacterial Cellulose/MoS2-Chitosan Nanocomposite Materials with Visible Light Illumination}, volume={13}, ISSN={["1944-8252"]}, DOI={10.1021/acsami.1c08178}, abstractNote={Owing to the rise in prevalence of multidrug-resistant pathogens attributed to the overuse of antibiotics, infectious diseases caused by the transmission of microbes from contaminated surfaces to new hosts are an ever-increasing threat to public health. Thus, novel materials that can stem this crisis, while also functioning via multiple antimicrobial mechanisms so that pathogens are unable to develop resistance to them, are in urgent need. Toward this goal, in this work, we developed in situ grown bacterial cellulose/MoS2-chitosan nanocomposite materials (termed BC/MoS2-CS) that utilize synergistic membrane disruption and photodynamic and photothermal antibacterial activities to achieve more efficient bactericidal activity. The BC/MoS2-CS nanocomposite exhibited excellent antibacterial efficacy, achieving 99.998% (4.7 log units) and 99.988% (3.9 log units) photoinactivation of Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus, respectively, under visible-light illumination (xenon lamp, 500 W, λ ≥ 420 nm, and 30 min). Mechanistic studies revealed that the use of cationic chitosan likely facilitated bacterial membrane disruption and/or permeability, with hyperthermia (photothermal) and reactive oxygen species (photodynamic) leading to synergistic pathogen inactivation upon visible-light illumination. No mammalian cell cytotoxicity was observed for the BC/MoS2-CS membrane, suggesting that such composite nanomaterials are attractive as functional materials for infection control applications.}, number={26}, journal={ACS APPLIED MATERIALS & INTERFACES}, author={Shen, Huiying and Jiang, Chenyu and Li, Wei and Wei, Qufu and Ghiladi, Reza A. and Wang, Qingqing}, year={2021}, month={Jul}, pages={31193–31205} }
 @article{nie_jiang_wu_chen_lv_wang_liu_narh_cao_ghiladi_et al._2020, title={Carbon quantum dots: A bright future as photosensitizers for in vitro antibacterial photodynamic inactivation}, volume={206}, ISSN={1011-1344}, url={http://dx.doi.org/10.1016/j.jphotobiol.2020.111864}, DOI={10.1016/j.jphotobiol.2020.111864}, abstractNote={Carbon nanomaterials have increasingly gained the attention of the nano-, photo- and biomedical communities owing to their unique photophysical properties. Here, we facilely synthesized carbon quantum dots (CQDs) in a one-pot solvothermal reaction, and demonstrated their utility as photosensitizers for in vitro antibacterial photodynamic inactivation (aPDI). The bottom-up synthesis employed inexpensive and sustainable starting materials (citric acid), used ethanol as an environmentally-friendly solvent, was relatively energy efficient, produced minimal waste, and purification was accomplished simply by filtration. The CQDs were characterized by both physical (TEM, X-ray diffraction) and spectroscopic (UV–visible, fluorescence, and ATR-FTIR) methods, which together confirmed their nanoscale dimensions and photophysical properties. aPDI studies demonstrated detection limit inactivation (99.9999 + %) of Gram-negative Escherichia coli 8099 and Gram-positive Staphylococcus aureus ATCC-6538 upon visible light illumination (λ ≥ 420 nm, 65 ± 5 mW/cm2; 60 min). Post-illumination SEM images of the bacteria incubated with the CQDs showed perforated and fragmented cell membranes consistent with damage from reactive oxygen species (ROS), and mechanistic studies revealed that the bacteria were inactivated by singlet oxygen, with no discernable roles for other ROS (e.g., superoxide or hydroxyl radicals). These findings demonstrated that CQDs can be facilely prepared, operate via a Type II mechanism, and are effective photosensitizers for in vitro aPDI.}, journal={Journal of Photochemistry and Photobiology B: Biology}, publisher={Elsevier BV}, author={Nie, Xiaolin and Jiang, Chenyu and Wu, Shuanglin and Chen, Wangbingfei and Lv, Pengfei and Wang, Qingqing and Liu, Jingyan and Narh, Christopher and Cao, Xiuming and Ghiladi, Reza A. and et al.}, year={2020}, month={May}, pages={111864} }