Works (165)

Updated: April 4th, 2024 20:45

2023 article

A computational study of droplet-spray formation from pressurized metered dose inhalers with applications to drug deposition in a human lung-airway model

Sridhar, K., Chari, S., & Kleinstreuer, C. (2023, March 16). AEROSOL SCIENCE AND TECHNOLOGY.

By: K. Sridhar n, S. Chari n & C. Kleinstreuer n

author keywords: Jonathan P; Reid
TL;DR: The general problems of high, wasteful oropharyngeal deposition and cold impacting droplets were tackled by devising a new ‘pulsed injection’ strategy in which the spray was broken into pulses with a time delay between them, indicating up to a 20% increase in useful lung deposition beyond the oropharyx over conventional drug administration methods. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: May 1, 2023

2022 journal article

An effective PBPK model predicting dissolved drug transfer from a representative nasal cavity to the blood stream

JOURNAL OF AEROSOL SCIENCE, 160.

By: S. Dave n, C. Kleinstreuer n & S. Chari n

author keywords: Intranasal drugs; Hybrid CFPD-PBPK model; Disposition of inhaled drugs; Pharmacokinetic modeling; Drug concentrations in the blood stream
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 7, 2022

2022 journal article

Analysis of improved oral drug delivery with different helical stream inhalation modes

COMPUTERS IN BIOLOGY AND MEDICINE, 141.

By: A. Gurumurthy & C. Kleinstreuer n

author keywords: Pulmonary drug delivery; Polydisperse particle distribution; Subject-specific upper lung airway geometry; Helical drug-aerosol streams; Swirl number; Angled helical injection; Radially positioned helical injection; Lobe-specific drug targeting
MeSH headings : Administration, Inhalation; Aerosols; Drug Delivery Systems; Lung; Metered Dose Inhalers; Particle Size; Rivers
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: February 7, 2022

2022 journal article

Effects of subject-variability on nasally inhaled drug deposition, uptake, and clearance

JOURNAL OF AEROSOL SCIENCE, 165.

By: S. Chari n, K. Sridhar n & C. Kleinstreuer n

author keywords: Nasal geometric variabilities; CF-PD analysis With updated OpenFOAM; solver; Inhaled drug-aerosol transport and uptake; Mucus layer dynamics; Mucociliary clearance; Dissolution and absorption of three generic; drugs
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: July 5, 2022

2021 journal article

Comparison of micron- and nano-particle transport in the human nasal cavity with a focus on the olfactory region

COMPUTERS IN BIOLOGY AND MEDICINE, 128.

By: S. Vachhani n & C. Kleinstreuer n

author keywords: Nasal cavities; Olfactory bulb; Nanoparticles; Micron-particles; Drug deposition
MeSH headings : Administration, Inhalation; Computer Simulation; Drug Delivery Systems; Humans; Models, Biological; Nasal Cavity; Particle Size
TL;DR: With a focus on the olfactory region, the detailed analysis of sectional deposition concentrations, considering a wide range of particle diameters, provide new physical insight to the particle dynamics inside human nasal cavities. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: February 1, 2021

2021 journal article

Computational analysis of a 3D mucociliary clearance model predicting nasal drug uptake

JOURNAL OF AEROSOL SCIENCE, 155.

By: S. Chari n, K. Sridhar n, R. Walenga* & C. Kleinstreuer n

author keywords: Mucociliary clearance; Nasal drug dissolution and absorption; CFD analysis of inhaled drug-aerosol transport; and uptake; Mucus layer dynamics; 3D modeling
TL;DR: A novel 3D meshing technique allows for the smooth capture of both the relatively large flow domain as well as the micron-size mucus layer and shows that drugs with a high partition coefficient are absorbed rapidly and drugs with higher solubility show an appreciable increase in cumulative uptake in the epithelium. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 10, 2021

2021 book

Essentials of Engineering Thermodynamics: Principles and Applications

New York: McGraw-Hill Education.

By: C. Kleinstreuer

Source: NC State University Libraries
Added: November 13, 2023

2021 journal article

Helical fluid-particle flow dynamics for controlling micron-particle deposition in a representative human upper lung-airway model

JOURNAL OF AEROSOL SCIENCE, 151.

By: A. Gurumurthy & C. Kleinstreuer n

author keywords: Helical air-particle inlet streams; Micron-particle deposition; Human upper respiratory tract; Drug-delivery applications; Open-FOAM software
TL;DR: Helical air-particle flow is introduced, which significantly affects the particle dynamics with applications to targeted drug delivery and a new non-dimensional parameter called the swirl number threshold (Sth) is discussed, which is useful in assessing the impact of helical streams in drug-aerosol delivery. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: December 21, 2020

2021 journal article

Improving Pulmonary Nanotherapeutics Using Helical Aerosol Streams: An In Silico Study

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 143(11).

By: A. Gurumurthy & C. Kleinstreuer n

author keywords: helical drug-aerosol streams; nanoparticles; human upper respiratory tract; improved drug delivery; CFD; openfoam
MeSH headings : Hydrodynamics
TL;DR: This study numerically analyzes a novel methodology of incorporating helical air-nanoparticle streams for pulmonary nano-therapeutics, using a customized version of the open-source computational fluid dynamics (CFD) toolbox OpenFOAM, and demonstrates the robustness of helical flows in pulmonary drug delivery. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 18, 2021

2021 article

Numerical analysis of enhanced nano-drug delivery to the olfactory bulb

Vachhani, S., & Kleinstreuer, C. (2021, July 24). AEROSOL SCIENCE AND TECHNOLOGY.

By: S. Vachhani n & C. Kleinstreuer n

author keywords: Yannis Drossinos
TL;DR: The main objective of this study is to utilize the Particle Release Map (PRM) methodology to optimize the nanodrug deposition efficiency inside the olfactory region, using a representative human nasal cavity as a test bed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 23, 2021

2020 journal article

High-temperature effects on the mucus layers in a realistic human upper airway model

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 163.

By: N. Kulkarni n & C. Kleinstreuer n

author keywords: Mucus layer; High temperature; Mass transfer; Evaporation
TL;DR: Interestingly, as a confirmation of the Reynolds analogy, the areas of significant wall heat flux and associated wall shear stress coincided with the regions of highest mucus evaporation, resulting in the humidification of the air with low relative humidity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 4, 2021

2019 journal article

A new collision model for ellipsoidal particles in shear flow

JOURNAL OF COMPUTATIONAL PHYSICS, 376, 1028–1050.

By: N. Saini & C. Kleinstreuer*

author keywords: Collision model; Ellipsoidal particle interaction; Discrete element method; Dynamic sphere generation
TL;DR: A new theory for particle transport, collision and wall interaction is presented which is more accurate computationally and more efficient than the multi-sphere method and compared with 3-D numerical benchmark results which relied on the MS method. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: December 10, 2018

2019 journal article

Heterogeneous blood flow in microvessels with applications to nanodrug transport and mass transfer into tumor tissue

BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, 18(1), 99–110.

By: Z. Xu n & C. Kleinstreuer n

author keywords: Computer simulation; Cell-free layer; Nanodrug delivery; Extravasation
MeSH headings : Antineoplastic Agents / therapeutic use; Biological Transport; Diffusion; Drug Delivery Systems; Hematocrit; Hemorheology; Humans; Microvessels / physiology; Nanoparticles / chemistry; Neoplasms / drug therapy; Regional Blood Flow / physiology; Reproducibility of Results
TL;DR: The present modeling framework and NP flux results provide new physical insight and can be readily extended to simulations of NP transport in blood microvessels of actual tumors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 25, 2019

2019 journal article

Mice-to-men comparison of inhaled drug-aerosol deposition and clearance

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 260, 82–94.

By: A. Kolanjiyil n, C. Kleinstreuer n, N. Kleinstreuer*, W. Pham* & R. Sadikot*

author keywords: Lung deposition; Mouse lung model; Human lung model; Dose extrapolation; Pharmacokinetics
MeSH headings : Administration, Inhalation; Aerosols / administration & dosage; Animals; Computer Simulation; Female; Humans; Hydrodynamics; Lung / anatomy & histology; Lung / physiology; Male; Mice; Models, Biological; Pulmonary Ventilation / physiology
TL;DR: The presented computer simulation models provide detailed fluid-particle dynamics results for upper lung airways of representative human and mouse models with a comparative analysis of particle lung deposition data, including a novel mice-to-men correlation as well as a particle-clearance analysis both useful for pharmacokinetic and toxicokinetic studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 11, 2019

2019 journal article

Modeling Airflow and Particle Deposition in a Human Acinar Region

COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE, 2019.

By: A. Kolanjiyil n & C. Kleinstreuer n

MeSH headings : Acinar Cells / physiology; Computer Simulation; Humans; Imaging, Three-Dimensional; Models, Anatomic; Models, Biological; Particulate Matter / pharmacokinetics; Pulmonary Alveoli / anatomy & histology; Pulmonary Alveoli / physiology; Respiration; Respiratory Mechanics / physiology
TL;DR: A physiologically inspired whole acinar model has been developed that can be readily incorporated into human whole-lung airway models to simulate/predict the flow dynamics of toxic or therapeutic aerosols. (via Semantic Scholar)
Source: Web Of Science
Added: February 11, 2019

2019 review

Recent advances in modeling and simulation of nanofluid flows-Part I: Fundamentals and theory

[Review of ]. PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS, 790, 1–48.

By: O. Mahian*, L. Kolsi*, M. Amani*, P. Estelle*, G. Ahmadi*, C. Kleinstreuer n, J. Marshalli, M. Siavashi* ...

author keywords: Nanofluids; Thermophysical properties; Dynamics of nanoparticles; Physical models
Source: Web Of Science
Added: March 18, 2019

2019 review

Recent advances in modeling and simulation of nanofluid flows-Part II: Applications

[Review of ]. PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS, 791, 1–59.

author keywords: Nanofluids; Physical models; 3D modeling; CFD techniques
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: March 18, 2019

2018 journal article

An in silico inter-subject variability study of extra-thoracic morphology effects on inhaled particle transport and deposition

JOURNAL OF AEROSOL SCIENCE, 123, 185–207.

author keywords: Individualized pulmonary drug delivery; Health risk assessment; Precise treatment; Computational fluid-particle dynamics (CFPD); Inter-subject variability; Virtual population study
TL;DR: An experimentally validated Computational Fluid-Particle Dynamics (CFPD) model based on the Euler-Lagrange method is developed and results indicate that the glottis constriction is the morphological parameter that significantly impacts the inhaled particle dynamics in the respiratory tract. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 19, 2018

2018 journal article

Convective mass and heat transfer enhancement of nanofluid streams in bifurcating microchannels

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 125, 1212–1229.

By: S. Chari n & C. Kleinstreuer n

author keywords: Microchannel mixing; Heat transfer; Pulsatile flow; Geometry optimization; Empirical correlation
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 19, 2018

2018 journal article

Direct nanodrug delivery for tumor targeting subject to shear-augmented diffusion in blood flow

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 56(11), 1949–1958.

By: Z. Xu n & C. Kleinstreuer n

author keywords: Nanodrug delivery; Red blood cell interaction; Liver tumor targeting; Shear-induced diffusion; Computer simulations
MeSH headings : Computer Simulation; Diffusion; Drug Delivery Systems / methods; Humans; Hydrodynamics; Nanoparticles / administration & dosage; Neoplasms / drug therapy; Particle Size; Pharmaceutical Preparations / administration & dosage; Regional Blood Flow / physiology
TL;DR: Results from computer simulations under physiologically realistic conditions indicate that shear-induced diffusion has a significant effect on nanoparticle transport, even in large arteries, and direct nanodrug delivery to tumor-feeding hepatic artery branches is feasible. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: November 5, 2018

2018 journal article

Effects of thermal airflow and mucus-layer interaction on hygroscopic droplet deposition in a simple mouth–throat model

Aerosol Science and Technology, 52(8), 900–912.

By: X. Chen*, C. Kleinstreuer n, W. Zhong*, Y. Feng* & X. Zhou*

Source: Crossref
Added: August 28, 2020

2018 book

Modern Fluid Dynamics

By: K. Clement

Source: Crossref
Added: February 5, 2022

2018 journal article

Subject-variability effects on micron particle deposition in human nasal cavities

JOURNAL OF AEROSOL SCIENCE, 115, 12–28.

By: H. Calmet*, C. Kleinstreuer n, G. Houzeaux*, A. Kolanjiyil n, O. Lehmkuhl*, E. Olivares*, M. Vazquez*

author keywords: Nasal cavities; Particle transport/deposition; Computational fluid-particle dynamics
TL;DR: Computer simulations of the airflow and particle dynamics in human nasal cavities are important for local, segmental and total deposition predictions of both inhaled toxic and therapeutic particles, and a new dimensionless group with which total particle deposition efficiency curves are very similar for all airway models is developed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Computational analysis of aerosol-dynamics in a human whole-lung airway model

JOURNAL OF AEROSOL SCIENCE, 114, 301–316.

By: A. Kolanjiyil n & C. Kleinstreuer n

author keywords: Whole-lung airway model; Particle deposition; Lung air-particle dynamics; Local and total lung depositions; Actual breathing modes; Alveolar region
TL;DR: The new whole-lung airway model (WLAM) can be used for local, segmental and total deposition predictions of inhaled toxic or therapeutic aerosols, and for providing inhaler-design guidelines to improve drug-aerosol targeting. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Computationally efficient analysis of particle transport and deposition in a human whole-lung-airway model. Part II: Dry powder inhaler application

Computers in Biology and Medicine, 84, 247–253.

By: A. Kolanjiyil n, C. Kleinstreuer n & R. Sadikot*

author keywords: Lung; Airflow; Whole lung-airway modeling; Computational fluid-particle dynamics (CF-PD); Particle deposition; Pharmaceutical aerosols; Dry powder inhaler (DPI); Curcumin
MeSH headings : Administration, Inhalation; Aerosols / administration & dosage; Aerosols / pharmacokinetics; Computer Simulation; Curcumin / administration & dosage; Curcumin / pharmacokinetics; Dry Powder Inhalers; Humans; Hydrodynamics; Lung / metabolism; Lung / physiology; Models, Biological; Particle Size
TL;DR: It can be concluded that use of a DPI leads to low lung deposition efficiencies because large amounts of drugs are deposited in the oral cavity, and the output of a modified DPI has been evaluated to achieve improved drug delivery, especially needed when targeting the smaller lung airways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: February 24, 2020

2017 journal article

Numerical investigation of the interaction, transport and deposition of multicomponent droplets in a simple mouth-throat model

JOURNAL OF AEROSOL SCIENCE, 105, 108–127.

By: X. Chen*, Y. Feng*, W. Zhong* & C. Kleinstreuer n

author keywords: Multicomponent droplet inhalation; droplet-vapor interaction; airway-wall condition; hygroscopic growth; deposition efficiency
TL;DR: Simulation results indicate that the hygroscopic growth of sodium chloride particles is sensitive to the saturation pressure of water vapor, which could be utilized to reduce the deposition of submicron hyGroscopic aerosol in the upper airway. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Computational transport, phase change and deposition analysis of inhaled multicomponent droplet-vapor mixtures in an idealized human upper lung model

JOURNAL OF AEROSOL SCIENCE, 96, 96–123.

By: Y. Feng n, C. Kleinstreuer n, N. Castro* & A. Rostami*

author keywords: Hygroscopic droplet growth; Multi-component droplet-vapor interaction modeling; Multi-component mixture plus discrete-droplet (MCM-DD) model; Inhaled droplet-reduction (IDR) method; Electronic cigarettes
TL;DR: Results indicate that liquid–vapor phase change induces hygroscopic growth of droplets, which in turn impacts significantly the deposition concentrations of aerosols via inertial impaction, secondary flows, Brownian motion, and the vapor-specific absorption rates. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Computationally efficient analysis of particle transport and deposition in a human whole-lung-airway model. Part I: Theory and model validation

COMPUTERS IN BIOLOGY AND MEDICINE, 79, 193–204.

By: A. Kolanjiyil n & C. Kleinstreuer n

author keywords: Lung; Airflow; Whole lung airway modeling; Computational fluid dynamics; Particle deposition
MeSH headings : Computational Biology; Computer Simulation; Humans; Hydrodynamics; Lung / physiology; Models, Biological; Respiratory Mechanics / physiology; Respiratory Transport / physiology; Trachea / physiology
TL;DR: The present new whole-lung-airway model (WLAM) represents the actual lung geometry via a basic 3-D mouth-to-trachea configuration while all subsequent airways are lumped together, i.e., reduced to an exponentially expanding 1-D conduit. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Experimental-computational study of fibrous particle transport and deposition in a bifurcating lung model

PARTICUOLOGY, 28, 102–113.

author keywords: Lung aerosol dynamics; Image-processing method; Fiber deposition data; Computer simulations; Deposited fiber orientations
TL;DR: Results for particle deposition using a lung model with a vertical bifurcation indicate that body position also affects deposition, and suggests these characteristics can be used to estimate fiber deposition in the lower airways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Laminar/turbulent airflow and microsphere deposition in a patient-specific airway geometry using an open-source solver

INTERNATIONAL JOURNAL OF BIOMEDICAL ENGINEERING AND TECHNOLOGY, 22(2), 145–161.

By: M. Vaish n, C. Kleinstreuer n, A. Kolanjiyil n, N. Saini n & N. Pillalamarri*

author keywords: OpenFOAM solver; patient-specific geometry and idealised configuration; modified eddy interaction model; microsphere transport and deposition; practical Stokes number range
TL;DR: Using the open-source software OpenFOAM as the solver, airflow and microsphere transport have been simulated in a patient-specific lung-airway model and results indicate that selection of an appropriate near-wall correction factor can reduce the problem of subject variability for different lung- airway configurations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Solid Tumor Embolotherapy in Hepatic Arteries with an Anti-reflux Catheter System

ANNALS OF BIOMEDICAL ENGINEERING, 44(4), 1036–1046.

By: Z. Xu n, S. Jernigan n, C. Kleinstreuer n & G. Buckner n

author keywords: Liver cancer; Transient particle-hemodynamics; Embolization; Particle-reflux; Infusion-stop point; Excessive particle capture
MeSH headings : Blood Pressure; Carcinoma, Hepatocellular / therapy; Catheters; Embolization, Therapeutic; Hemodynamics; Hepatic Artery / physiology; Humans; Liver Neoplasms / therapy; Microspheres; Models, Biological
TL;DR: The results show that the present procedure for embolization of downstream vessels which feed a tumor is quite arbitrary, Nevertheless, a method to recycle aberrant particles captured by the deployed tip was proposed to minimize side-effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

A Lagrangian Approach for Calculating Microsphere Deposition in a One-Dimensional Lung-Airway Model

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 137(9).

By: M. Vaish n & C. Kleinstreuer n

author keywords: lung-equivalent trumpet model; OPENFOAM solver; radial force function; microsphere transport; total lung deposition
MeSH headings : Air; Humans; Lung / metabolism; Microspheres; Models, Biological
TL;DR: Using the open-source software openfoam as the solver, a novel approach to calculate microsphere transport and deposition in a 1D human lung-equivalent trumpet model (TM) is presented and a new radial force has been developed which generates particle trajectories toward the wall. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Computationally Efficient Fluid-Particle Dynamics Simulations of Arterial Systems

COMMUNICATIONS IN COMPUTATIONAL PHYSICS, 17(2), 401–423.

By: T. Umbarkar n & C. Kleinstreuer n

author keywords: 1-D modeling; skewed representative velocity profile; fluid-structure interaction; particle tracking
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Evaporation and condensation of multicomponent electronic cigarette droplets and conventional cigarette smoke particles in an idealized G3-G6 triple bifurcating unit

JOURNAL OF AEROSOL SCIENCE, 80, 58–74.

By: Y. Feng n, C. Kleinstreuer n & A. Rostami*

author keywords: Electronic cigarette (EC); Conventional cigarette smoke particles (CSPs); Multicomponent droplets; Deposition; Droplet-vapor interaction modeling; Multicomponent Mixture plus Discrete; Droplet (MM-DD) model
TL;DR: The results indicate that EC-droplets, being more hygroscopic than cigarette smoke particles, tend to grow larger in maximum size in a typically highly humid environment. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Computationally Efficient Particle Release Map Determination for Direct Tumor-Targeting in a Representative Hepatic Artery System

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 136(1).

By: E. Childress n & C. Kleinstreuer n

author keywords: drug-particle transport; tumor-targeting; computational efficiency
MeSH headings : Antineoplastic Agents / administration & dosage; Computer Simulation; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Hepatic Artery / physiology; Humans; Infusions, Intra-Arterial; Microspheres; Models, Cardiovascular; Pulsatile Flow
TL;DR: While the best steady PRMs provide a qualitative guide for best catheter placement, the final injection position could be adjusted in vivo using biodegradable mock-spheres to ensure that patient-specific optimal tumor-targeting is achieved. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Concentration photovoltaic-thermal energy co-generation system using nanofluids for cooling and heating

ENERGY CONVERSION AND MANAGEMENT, 87, 504–512.

By: Z. Xu n & C. Kleinstreuer n

author keywords: Co-generation; Concentration photovoltaic-thermal (CPV/T) system; Nanofluid thermal conductivity; System efficiencies
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 conference paper

DDPM-DEM simulations of particulate flows in human tracheobronchial airways

Proceedings of the ASME International Mechanical Engineering Congress and Exposition, 2013, vol 3B.

By: Y. Feng n & C. Kleinstreuer n

TL;DR: Twoway coupling of the Dense Dispersed Phase Model (DDPM) combined with the Discrete Element Method (DEM) has been introduced into the commercial CFD software via inhouse codes, and more comprehensive and robust computational models based on the DDPM� DEM method have been developed, which can accurately predict the dynamics of dense particle suspensions. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Impact of Fluid-Structure Interaction on Direct Tumor-Targeting in a Representative Hepatic Artery System

ANNALS OF BIOMEDICAL ENGINEERING, 42(3), 461–474.

By: E. Childress n & C. Kleinstreuer n

author keywords: Optimal tumor-targeting; Drug particles; Fluid-particle dynamics; Fluid-structure interaction; Rigid-wall assumption
MeSH headings : Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / pharmacology; Computer Simulation; Drug Delivery Systems; Hemorheology; Hepatic Artery / physiopathology; Humans; Liver Neoplasms / blood supply; Liver Neoplasms / drug therapy; Liver Neoplasms / physiopathology; Models, Cardiovascular
TL;DR: The impact of fluid–structure interaction on direct drug-targeting is evaluated, using a representative hepatic artery system with liver tumor as a test bed and it was found that the best rigid geometry is the physiological one that occurs during the diastolic targeting interval. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Micron-particle transport, interactions and deposition in triple lung-airway bifurcations using a novel modeling approach

JOURNAL OF AEROSOL SCIENCE, 71, 1–15.

By: Y. Feng n & C. Kleinstreuer n

author keywords: Dense discrete phase model (DDPM); Discrete element method (DEM); Lung aerosol dynamics; Triple bifurcations; Particle-particle interactions; Model combination criteria
TL;DR: The validity and necessity of the DDPM–DEM approach for different lung airway generations were numerically investigated, and a new criterion for CF–PD model combination in terms of a relationship between inlet-particle stacking-volume fraction, ϕ, and percentage-of-fate changing particles, Δ β p is proposed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 review

A review of entropy generation in nanofluid flow

[Review of ]. INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 65, 514–532.

By: O. Mahian*, A. Kianifar*, C. Kleinstreuer n, M. Al-Nimr*, I. Pop*, A. Sahin*, S. Wongwises*

author keywords: Nanofluid flow; Thermophysical property; Entropy generation
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Analysis of non-spherical particle transport in complex internal shear flows

PHYSICS OF FLUIDS, 25(9).

By: Y. Feng n & C. Kleinstreuer n

TL;DR: The one-way coupled Euler-Lagrange method enhanced by Euler's rotation equations is then employed to simulate laminar-turbulent flow in a subject-specific lung-airway model to gain basic insight into the dynamics of non-spherical particles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 review

Computational Analysis of Non-Spherical Particle Transport and Deposition in Shear Flow With Application to Lung Aerosol Dynamics-A Review

[Review of ]. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 135(2).

By: C. Kleinstreuer n & Y. Feng n

author keywords: lung-aerosol dynamics; nonspherical particles; particle transport and deposition
MeSH headings : Aerosols; Biological Transport; Biomechanical Phenomena; Humans; Hydrodynamics; Lung / metabolism; Lung / physiology; Mechanical Phenomena
TL;DR: Focusing on the modeling and simulation of inhaled aerosols, theories for both spherical and nonspherical particles are reviewed to analyze the contrasting transport and deposition phenomena of spheres and equivalent spheres versus ellipsoids and fibers. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Critical Invalidation of Temperature Dependence of Nanofluid Thermal Conductivity Enhancement

JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME, 135(5).

By: K. Han*, W. Lee*, C. Kleinstreuer n & J. Koo*

author keywords: transient hot-wire method; thermal conductivity; nanofluids; natural convection
Source: Web Of Science
Added: August 6, 2018

2013 review

Lung Deposition Analyses of Inhaled Toxic Aerosols in Conventional and Less Harmful Cigarette Smoke: A Review

[Review of ]. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 10(9), 4454–4485.

By: C. Kleinstreuer n & Y. Feng n

author keywords: conventional or less harmful cigarettes; aerosol toxicology; cigarette smoke droplet; vapor deposition; second-hand smoke; impact analysis; computational fluid-particle dynamics
MeSH headings : Aerosols; Humans; Inhalation Exposure; Lung / metabolism; Smoke / adverse effects; Tobacco; Tobacco Products / toxicity; Vulnerable Populations
TL;DR: An overview of contributions mainly published between 2009 and 2013, focusing on the potential health risks of toxicants in cigarette smoke, progress made in different approaches of impact analyses for inhaled toxic aerosols, as well as challenges and future directions are served. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Nanoparticle Mass Transfer From Lung Airways to Systemic Regions-Part I: Whole-Lung Aerosol Dynamics

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 135(12).

By: A. Kolanjiyil n & C. Kleinstreuer n

author keywords: computational fluid-particle dynamics; multicompartment modeling; nanoparticle kinetics; nanoparticle deposition; toxic nanoparticles; nanodrugs
MeSH headings : Aerosols; Humans; Inhalation; Lung / metabolism; Lung / physiology; Models, Biological; Nanoparticles / chemistry; Particle Size; Pulmonary Alveoli / metabolism; Reproducibility of Results; Tissue Distribution
TL;DR: Combining high-resolution computer simulation results of inhaled NP deposition in the human airways with a multicompartmental model for NP-mass transfer allows for the prediction of temporal NP accumulation in the blood and lymphatic systems as well as in organs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Nanoparticle Mass Transfer From Lung Airways to Systemic Regions-Part II: Multi-Compartmental Modeling

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 135(12).

By: A. Kolanjiyil n & C. Kleinstreuer n

author keywords: multicompartment modeling; animal test data; model validations; nanoparticle bio-kinetics; temporal accumulations; human organs
MeSH headings : Animals; Body Weight; Humans; Hydrodynamics; Inhalation; Lung / metabolism; Lung / physiology; Models, Biological; Nanoparticles; Organ Specificity; Rats; Tissue Distribution
TL;DR: High-resolution computer simulation results of inhaled nanoparticle deposition in a human airway model with a new multicompartmental model for insoluble nanoparticle barrier mass transfer into systemic regions provide critical insight into nanomaterial deposition and distribution from the lungs to systemic regions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Experimental Microsphere Targeting in a Representative Hepatic Artery System

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 59(1), 198–204.

By: A. Richards n, C. Kleinstreuer n, A. Kennedy, E. Childress n & G. Buckner n

author keywords: Computational fluid-particle dynamics; hepatic artery (HA); liver tumor; radioembolization (RE)
MeSH headings : Animals; Blood Flow Velocity / physiology; Blood Physiological Phenomena; Brachytherapy / instrumentation; Computer Simulation; Drug Carriers / chemistry; Hepatic Artery / physiopathology; Humans; Microspheres; Models, Cardiovascular; Motion; Radiopharmaceuticals / chemistry; Rheology / methods
TL;DR: The experimental results validate the simulation methodology for achieving targeted microsphere distributions in a known geometry under constant flow conditions and exhibited a clear dependence on injection location that correlated very strongly with the computationally predicted results. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Size-change and deposition of conventional and composite cigarette smoke particles during inhalation in a subject-specific airway model

JOURNAL OF AEROSOL SCIENCE, 46, 34–52.

By: Z. Zhang n, C. Kleinstreuer n & S. Hyun*

author keywords: Respiratory deposition; Cigarette smoke particles; Subject-specific human upper airways; Computational analysis; Potential reduced exposure tobacco products
TL;DR: It is demonstrated that changes in cigarette composition significantly influence the hygroscopic growth of CSPs and is helpful for quantitatively evaluating the dose-exposure and subsequent health effects of both conventional and potentially less-harmful cigarettes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 article

Thermal Nanofluid Property Model With Application to Nanofluid Flow in a Parallel Disk System-Part II: Nanofluid Flow Between Parallel Disks

Feng, Y., & Kleinstreuer, C. (2012, May). JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME, Vol. 134.

By: Y. Feng n & C. Kleinstreuer n

author keywords: nanofluid flow; augmented heat transfer; parallel disk system
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 article

Thermal Nanofluid Property Model With Application to Nanofluid Flow in a Parallel-Disk System-Part I: A New Thermal Conductivity Model for Nanofluid Flow

Kleinstreuer, C., & Feng, Y. (2012, May). JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME, Vol. 134.

By: C. Kleinstreuer n & Y. Feng n

author keywords: nanofluids; thermal conductivity enhancement; new theory; data comparisons
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Vapor deposition during cigarette smoke inhalation in a subject-specific human airway model

JOURNAL OF AEROSOL SCIENCE, 53, 40–60.

By: Z. Zhang n, C. Kleinstreuer n & Y. Feng n

author keywords: Cigarette smoke; Respiratory vapor mass transfer and deposition; Transient puffing and inhalation; Subject-specific human upper airways; Computational analysis; Quantitative data sets for toxicologists
TL;DR: Results show that vapor deposition is strongly influenced by its property values as well as inhalation waveform, i.e., puffing behavior, and a correction factor has been proposed, considering vapor transport delay, in order to calculate efficiently actual deposition fraction values under transient puffing condition. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

A Relation Between Near-Wall Particle-Hemodynamics and Onset of Thrombus Formation in Abdominal Aortic Aneurysms

ANNALS OF BIOMEDICAL ENGINEERING, 39(7), 2010–2026.

By: C. Basciano*, C. Kleinstreuer n, S. Hyun* & E. Finol*

author keywords: Patient-specific AAA; Computational analysis; ILT onset criteria
MeSH headings : Animals; Aorta, Abdominal / pathology; Aorta, Abdominal / physiopathology; Aortic Aneurysm, Abdominal / complications; Aortic Aneurysm, Abdominal / physiopathology; Blood Platelets; Computer Simulation; Humans; Leukocytes; Models, Cardiovascular; Shear Strength; Thrombosis / etiology; Thrombosis / physiopathology
TL;DR: The generalized results support the hypothesis that a patient’s AAA geometry and associated particle-hemodynamics have the potential to entrap activated blood particles, which will play a role in the onset of ILT. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Airflow analysis in the alveolar region using the lattice-Boltzmann method

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 49(4), 441–451.

By: Z. Li* & C. Kleinstreuer n

MeSH headings : Humans; Inhalation / physiology; Models, Biological; Pulmonary Alveoli / anatomy & histology; Pulmonary Alveoli / physiology; Respiratory Mechanics / physiology; Rheology
TL;DR: For a given set of realistic inlet conditions, the airflow velocity and vortical flows are greatly dependent on the different alveolar sac shapes, local geometric structures, and sac expansion rates, and the pressure distributions are less influenced by the alveolus shape and wall movement. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Analysis of Multi-Layer Immiscible Fluid Flow in a Microchannel

JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME, 133(11).

By: J. Li n, P. Sheeran n & C. Kleinstreuer n

author keywords: immiscible fluids; multilayer viscosities; non-newtonian fluids; pressure-driven flow; electroosmotic flow; microchannel entrance effects
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Computational analysis of airflow and nanoparticle deposition in a combined nasal-oral-tracheobronchial airway model

JOURNAL OF AEROSOL SCIENCE, 42(3), 174–194.

By: Z. Zhang n & C. Kleinstreuer n

author keywords: Breathing routes; Computational analysis; Laminar-to-turbulent airflow; Nanoparticle deposition efficiencies; Downstream resistances; Mass transfer correlation
TL;DR: It was found that the change in breathing route not only significantly influences nanoparticle deposition in the regions of nasal and oral cavities, nasopharynx and oropharynx, but also measurably affects depositions from pharynx to bronchial airways for tiny nanoparticles (≤5 nm). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Deposition of naphthalene and tetradecane vapors in models of the human respiratory system

INHALATION TOXICOLOGY, 23(1), 44–57.

By: Z. Zhang n & C. Kleinstreuer*

author keywords: Computational analysis; toxic vapor deposition; lung airway model
MeSH headings : Absorption; Alkanes / toxicity; Computer Simulation; Humans; Hydrocarbons / toxicity; Inhalation Exposure / adverse effects; Male; Middle Aged; Models, Biological; Naphthalenes / toxicity; Respiratory System / metabolism; Trachea / metabolism
TL;DR: The different deposition patterns of naphthalene and tetradecane vapors in the human respiratory system may indicate different toxic and hence health effects of these toxic jet-fuel components. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 review

Experimental and theoretical studies of nanofluid thermal conductivity enhancement: a review

[Review of ]. NANOSCALE RESEARCH LETTERS, 6.

By: C. Kleinstreuer n & Y. Feng n

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Impact analysis of natural convection on thermal conductivity measurements of nanofluids using the transient hot-wire method

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 54(15-16), 3448–3456.

By: S. Hong*, Y. Kang*, C. Kleinstreuer n & J. Koo*

author keywords: Transient hot-wire method (THWM); Thermal conductivity; Natural convection; Nanofluids
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Laminar-to-turbulent fluid-nanoparticle dynamics simulations: Model comparisons and nanoparticle-deposition applications

International Journal for Numerical Methods in Biomedical Engineering, 27(12), 1930–1950.

By: Z. Zhang n & C. Kleinstreuer n

author keywords: laminar-to-turbulent flow; nanoparticle deposition; computer simulation; human upper airways
TL;DR: LES and three widely used RANS turbulence models were compared and evaluated to gain new physical insight and provide useful turbulence modeling information and two geometric test cases may represent stenosed arteries and a segment of the human upper airways where the velocity fields undergo all flow regimes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Crossref
Added: February 24, 2020

2011 journal article

Optimal Drug-Aerosol Delivery to Predetermined Lung Sites

JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME, 133(1).

By: C. Kleinstreuer n & Z. Zhang n

author keywords: subject-specific lung airways; air-particle flow; computer simulation results; inhaler devices; optimal drug-aerosol targeting; smart inhaler system
TL;DR: This review summarizes computer simulation methodologies of air-particle flow, results of drug-aerosol transport/deposition in models of the human respiratory system, as well as aspects ofdrug-aerOSol targeting and associated inhalation devices. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 article

Airflow and Particle Transport in the Human Respiratory System

ANNUAL REVIEW OF FLUID MECHANICS, Vol. 42, pp. 301–334.

By: C. Kleinstreuer n & Z. Zhang*

author keywords: human respiratory air-way models; experimental observations and computer simulations; laminar/turbulent airflow structures; dilute suspensions of nanomaterial; solid particles or droplets; inhaled/exhaled aerosol transport and deposition
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2010 journal article

COMPUTER MODELING OF YTTRIUM-90-MICROSPHERE TRANSPORT IN THE HEPATIC ARTERIAL TREE TO IMPROVE CLINICAL OUTCOMES

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 76(2), 631–637.

By: A. Kennedy n, C. Kleinstreuer n, C. Basciano n & W. Dezarn*

author keywords: Hepatic artery system; Y-90-microspheres; Computer modeling; Blood flow; Particle transport
MeSH headings : Computer Simulation; Embolization, Therapeutic / methods; Hepatic Artery / anatomy & histology; Hepatic Artery / physiology; Humans; Liver / blood supply; Liver Circulation / physiology; Liver Neoplasms / blood supply; Liver Neoplasms / radiotherapy; Microspheres; Models, Cardiovascular; Yttrium Radioisotopes / pharmacokinetics; Yttrium Radioisotopes / therapeutic use
TL;DR: Computer simulations of both blood flow patterns and microsphere dynamics have the potential to provide valuable insight on how to optimize (90)Y-microsphere implantation into hepatic tumors while sparing normal tissue. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Computer Modeling of Controlled Microsphere Release and Targeting in a Representative Hepatic Artery System

ANNALS OF BIOMEDICAL ENGINEERING, 38(5), 1862–1879.

By: C. Basciano n, C. Kleinstreuer n, A. Kennedy*, W. Dezarn* & E. Childress n

author keywords: Computational fluid-particle dynamics; Yttrium-90 particle transport; Transient particle-hemodynamics; Non-Newtonian fluid; Drug-targeting methodology
MeSH headings : Animals; Computer Simulation; Drug Delivery Systems / methods; Hemodynamics / physiology; Hepatic Artery / physiology; Liver / blood supply; Liver Neoplasms / drug therapy; Liver Neoplasms / radiotherapy; Microspheres; Yttrium / adverse effects
TL;DR: Results begin paving the way towards directing 100% of the released microspheres to specific daughter vessels under transient flow conditions in realistic geometries via a novel drug-particle targeting methodology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Influence of aspect ratio on the dynamics of a freely moving circular disk

JOURNAL OF FLUID MECHANICS, 653, 463–487.

By: A. Shenoy* & C. Kleinstreuer n

Source: Web Of Science
Added: August 6, 2018

2010 journal article

Nanofluid convective heat transfer in a parallel-disk system

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 53(21-22), 4619–4628.

By: Y. Feng n & C. Kleinstreuer n

author keywords: Nanofluid; Convective heat transfer; Impinging-jet; Parallel disk; Entropy generation; Wall temperature control
Source: Web Of Science
Added: August 6, 2018

2009 journal article

An Adjustable Triple-Bifurcation Unit Model for Air-Particle Flow Simulations in Human Tracheobronchial Airways

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 131(2).

By: C. Kleinstreuer n & Z. Zhang n

author keywords: bifurcation; computational fluid dynamics; flow simulation; lung; nanoparticles; physiological models; pneumodynamics; turbulence
MeSH headings : Air; Bronchi / physiology; Computer Simulation; Humans; Lung / physiology; Models, Biological; Particle Size; Respiratory Mechanics; Trachea / physiology
TL;DR: The present study revealed that turbulent air-particle flow may propagate to G5 for the assumed inhalation flow rate, and geometry and upstream effects are more pronounced for micron particle deposition than for nanoparticle deposition. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Comparison of analytical and CFD models with regard to micron particle deposition in a human 16-generation tracheobronchial airway model

JOURNAL OF AEROSOL SCIENCE, 40(1), 16–28.

By: Z. Zhang n, C. Kleinstreuer n & C. Kim*

author keywords: Human tracheobronchial airways; Computational analysis; Micron particle deposition; Deposition efficiency; Deposition fraction
TL;DR: Surprisingly, simulated inspiratory deposition fractions for the entire tracheobronchial region with repeated TBUs in parallel and in series agree rather well with those calculated using analytical/semi-empirical expressions, however, the predicted particle-deposition fractions based on such analytical formulas differ greatly from the present simulation results. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Invariant-Based Anisotropic Constitutive Models of the Healthy and Aneurysmal Abdominal Aortic Wall

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 131(2).

By: C. Basciano n & C. Kleinstreuer n

author keywords: ab initio calculations; biomechanics; blood vessels; diseases; elasticity; physiological models
MeSH headings : Anisotropy; Aorta, Abdominal / physiology; Aortic Aneurysm, Abdominal / physiopathology; Biomechanical Phenomena; Computer Simulation; Elasticity; Humans; Models, Cardiovascular; Nonlinear Dynamics
TL;DR: Although the traditional invariant framework exhibits significant covariance, the invariant terms utilized in the new models exhibited limited covariance and are able to accurately reproduce experimental trends, suggesting numerical stability and potentially the inherent limitations of a covariant theoretical framework. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Microfluidics analysis of nanoparticle mixing in a microchannel system

MICROFLUIDICS AND NANOFLUIDICS, 6(5), 661–668.

By: J. Li n & C. Kleinstreuer n

author keywords: Microfluidics; Nanofluid; Micro-mixer; Heat and mass transfer; Nanodrug delivery
TL;DR: The microfluidics of controlled nanodrug delivery to living cells in a representative, partially heated microchannel was analyzed, using a validated computer model, and shows that both the baffle-slit micro-mixer and the perforated injection micro- Mixer aid in decreasing the microchannel length while achieving uniform nanoparticle exit concentrations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 journal article

A new methodology for targeting drug-aerosols in the human respiratory system

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 51(23-24), 5578–5589.

By: C. Kleinstreuer n, Z. Zhang n, Z. Li n, W. Roberts n & C. Rojas*

author keywords: Drug-aerosol inhalers; Targeted drug-aerosol delivery; Methodology for smart inhaler system; Experimental verification of new methodology
TL;DR: The new methodology introduces the idea of a controlled air-particle stream which provides maximum, patient-specific drug-aerosol deposition based on optimal particle diameter and density, inhalation waveform, and particle-release position. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

A nonlinear effective thermal conductivity model for carbon nanotube and nanofiber suspensions

NANOTECHNOLOGY, 19(37).

By: J. Koo*, Y. Kang* & C. Kleinstreuer n

TL;DR: It was found that the alignment of CNTs and CNFs due to the long range repulsion force decreases the excluded volume, leading to both the convex and concave nonlinear as well as linear increase of the thermal conductivity with particle concentration. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Airflow and Nanoparticle Deposition in a 16-Generation Tracheobronchial Airway Model

ANNALS OF BIOMEDICAL ENGINEERING, 36(12), 2095–2110.

By: Z. Zhang n, C. Kleinstreuer n & C. Kim*

author keywords: Human tracheobronchial region; Computational analysis; Airflow; Nanoparticle deposition; Deposition efficiencies; Deposition correlations
MeSH headings : Algorithms; Bronchi / physiology; Computer Simulation; Humans; Models, Biological; Nanoparticles; Particle Size; Pulmonary Ventilation; Reproducibility of Results; Trachea / physiology
TL;DR: It was found that fully developed flow and uniform nanoparticle concentrations can be assumed beyond generation G12 and the deposition efficiencies at each individual bifurcation in the TB region can be well correlated as a function of an effective diffusion parameter. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Computational mechanics of Nitinol stent grafts

JOURNAL OF BIOMECHANICS, 41(11), 2370–2378.

By: C. Kleinstreuer n, Z. Li*, C. Basciano n, S. Seelecke n & M. Farber n

author keywords: stent; stent graft; abdominal aortic aneurysm; Nitinol; graft material; finite element analysis; computer simulations; wall stress and strain; crimp; fatigue; fracture
MeSH headings : Alloys; Computer Simulation; Models, Biological; Stents; Stress, Mechanical
TL;DR: A Nitinol stent with PET graft may greatly improve fatigue life, while its compliance is much lower than the NITI-ePTFE combination, which is not acceptable for proper AAA stent-graft design. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Dilute suspension flow with nanoparticle deposition in a representative nasal airway model

PHYSICS OF FLUIDS, 20(1).

By: H. Shi n, C. Kleinstreuer n & Z. Zhang n

TL;DR: The understanding and quantitative assessment of mixture flow fields and local nanoparticle wall concentrations in nasal airways with a thin mucus layer are very important for estimating the health risks of inhaled toxic aerosols, determining proper drug-aerosol delivery to target sites such as the olfactory regions and developing algebraic transfer functions for overall nasal dose-response analyses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 article

Discussion: "Effects of various parameters on nanotluid thermal conductivity" ( Jang, S.P., and Choi, S.D.S., 2007, ASME J. heat transfer, 129, pp. 617-623)

Kleinstreuer, C., & Li, J. (2008, February). JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME, Vol. 130.

By: C. Kleinstreuer n & J. Li n

Source: Web Of Science
Added: August 6, 2018

2008 journal article

Flow over a thin circular disk at low to moderate Reynolds numbers

JOURNAL OF FLUID MECHANICS, 605, 253–262.

By: A. Shenoy n & C. Kleinstreuer n

Source: Web Of Science
Added: August 6, 2018

2008 journal article

Microfluidics of nano-drug delivery

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 51(23-24), 5590–5597.

By: C. Kleinstreuer n, J. Li n & J. Koo*

author keywords: Bio-MEMS; Drug delivery; Nanofluids; Microfluidics; Microchannel
TL;DR: The transient 3-D problem of controlled nano-drug delivery in a heated microchannel has been numerically solved to gain new physical insight and to determine suitable geometric and operational system parameters. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 review

Modeling airflow and particle transport/deposition in pulmonary airways

[Review of ]. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 163(1-3), 128–138.

By: C. Kleinstreuer n, Z. Zhang n & Z. Li n

author keywords: Pulmonary airways; Deposition enhancement factor; Tracheobronchial airways
MeSH headings : Aerosols; Computer Simulation; Humans; Models, Biological; Particle Size; Pulmonary Ventilation / physiology; Respiratory Transport / physiology
TL;DR: A review of research papers is presented, pertinent to computer modeling of airflow as well as nano- and micron-size particle deposition in pulmonary airway replicas, and optimal parameters for mechanical drug-aerosol targeting of predetermined lung areas can be computed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 article

Targeted drug-aerosol delivery in the human respiratory system

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, Vol. 10, pp. 195–220.

By: C. Kleinstreuer n, Z. Zhang n & J. Donohue*

author keywords: nasal and lung airways; nano- and micro-size aerosols; transport/deposition; present and proposed inhaler devices; methodology of optimal drug-aerosol targeting; computer simulations; experimental evidence
MeSH headings : Aerosols / administration & dosage; Aerosols / pharmacokinetics; Animals; Computer Simulation; Drug Delivery Systems / methods; Humans; Models, Biological; Pharmaceutical Preparations / administration & dosage; Pharmacokinetics; Respiratory System / metabolism
TL;DR: Experimental measurements and computer models of particle transport and deposition in nasal and lung airway models are presented and the underlying methodology and performance of pressurized metered dose inhalers as well as new smart inhaler systems are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Thermal performance of nanofluid flow in microchannels

INTERNATIONAL JOURNAL OF HEAT AND FLUID FLOW, 29(4), 1221–1232.

By: J. Li* & C. Kleinstreuer*

author keywords: Brownian motion; micro-mixing; effective thermal conductivity; nanofluid flow; microchannel heat sinks
Source: Web Of Science
Added: August 6, 2018

2007 journal article

A comparison between different asymmetric abdominal aortic aneurysm morphologies employing computational fluid-structure interaction analysis

EUROPEAN JOURNAL OF MECHANICS B-FLUIDS, 26(5), 615–631.

By: Z. Li* & C. Kleinstreuer n

author keywords: pulsatile 3-D blood flow; abdominal aortic aneurysms; AAA morphologies; maximum wall stress
TL;DR: The simulation results indicated that the assumption of symmetric AAA geometry may underestimate AAA-wall stress considerably, and the wall stress of lateral asymmetric AAAs is higher than for the anterior-posterior asymmetric types. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Combined inertial and gravitational deposition of microparticles in small model airways of a human respiratory system

JOURNAL OF AEROSOL SCIENCE, 38(10), 1047–1061.

By: C. Kleinstreuer n, Z. Zhang n & C. Kim*

author keywords: inertial impaction; gravitational sedimentation; micron particle deposition; small human airways; computational analysis; deposition efficiency; stokes number; fronde number; sedimentation parameter; deposition correlations
TL;DR: More prudent is the use of curve-fitted correlations generated from experimentally validated computer simulation results as a function of Stokes number and sedimentation parameter for predicting gravitational deposition in local bronchial airway segments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Computational analyses of a pressurized metered dose inhaler and a new drug-aerosol targeting methodology

JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG, 20(3), 294–309.

By: C. Kleinstreuer n, H. Shi* & Z. Zhang n

author keywords: computer simulation; droplet spray formation; pMDI performance; droplet transport/deposition; human upper airways; controlled air-particle stream; targeted drug-aerosol transport/deposition
MeSH headings : Aerosol Propellants / chemistry; Aerosols; Anti-Asthmatic Agents / administration & dosage; Anti-Asthmatic Agents / chemistry; Computer Simulation; Drug Delivery Systems / instrumentation; Equipment Design; Humans; Hydrocarbons, Fluorinated / chemistry; Inhalation Spacers; Metered Dose Inhalers; Models, Biological; Motion; Particle Size; Pressure; Reproducibility of Results; Respiratory System / anatomy & histology
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 review

Fluid-structure interaction analyses of stented abdominal aortic aneurysms

[Review of ]. Annual Review of Biomedical Engineering, 9, 169–204.

By: C. Kleinstreuer n, Z. Li* & M. Farber*

MeSH headings : Aorta, Abdominal / physiopathology; Aorta, Abdominal / surgery; Aortic Aneurysm, Abdominal / physiopathology; Aortic Aneurysm, Abdominal / surgery; Blood Flow Velocity; Blood Pressure; Blood Vessel Prosthesis; Computer Simulation; Humans; Models, Cardiovascular; Stents; Surgery, Computer-Assisted / methods
TL;DR: Computational fluid-structure interaction simulations provide physical insight into the hemodynamics coupled with multi-wall mechanics' function as an assessment tool for optimal SG placement and improved device design. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Modeling of inertial particle transport and deposition in human nasal cavities with wall roughness

JOURNAL OF AEROSOL SCIENCE, 38(4), 398–419.

By: H. Shi n, C. Kleinstreuer n & Z. Zhang n

author keywords: human nasal cavity; inertial particle decomposition; computer analysis; wall roughness
TL;DR: Considering drug–aerosol targeting, an optimal impaction parameter value exists which generates for normal inlet conditions the largest deposition in desired areas, e.g., the middle meatus, inferior meatus and olfactory regions, however, the absolute deposition efficiencies are very small because particles hardly reach those regions due to the complex nasal geometric structures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Particle deposition in the human tracheobronchial airways due to transient inspiratory flow patterns

JOURNAL OF AEROSOL SCIENCE, 38(6), 625–644.

By: Z. Li n, C. Kleinstreuer n & Z. Zhang n

author keywords: transient inhalation; laminar flow; turbulent flow; local flow pattern; micro-particle deposition; deposition fraction; drug-aerosol targeting
TL;DR: It is shown that the relation between particle-release positions at the trachea inlet and particle depositions at specific lung sites are greatly influenced by the complex airway geometry and the flow-rate magnitude. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Simulation and analysis of high-speed droplet spray dynamics

JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME, 129(5), 621–633.

By: H. Shi n & C. Kleinstreuer n

Source: Web Of Science
Added: August 6, 2018

2007 journal article

Simulation of airflow fields and microparticle deposition in realistic human lung airway models. Part I: Airflow patterns

EUROPEAN JOURNAL OF MECHANICS B-FLUIDS, 26(5), 632–649.

By: Z. Li n, C. Kleinstreuer n & Z. Zhang n

author keywords: asymmetric upper airways; transient 3-D airflow simulations; parabolic and realistic velocity inlet conditions; local velocity distributions
TL;DR: The main results can be summarized as follows: Considering two acceleration and deceleration time levels during transient inhalation as well as steady-state inhalation generating the same inlet Reynolds number, Re in - mean = 1201 , the airflow patterns are quite similar. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Simulation of airflow fields and microparticle deposition in realistic human lung airway models. Part II: Particle transport and deposition

EUROPEAN JOURNAL OF MECHANICS B-FLUIDS, 26(5), 650–668.

By: Z. Li n, C. Kleinstreuer n & Z. Zhang n

author keywords: asymmetric upper airways; matching inlet Reynolds number; 3-D microparticle transport simulations; particle depositions and segmental correlations
TL;DR: Based on current research results, the out-of-plane model with tracheal rings and realistic inlet condition is recommended for future work and significant differences were recorded when comparing DFs in some branches of the present realistic model and the Weibel Type A model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Analysis of biomechanical factors affecting stent-graft migration in an abdominal aortic aneurysm model

JOURNAL OF BIOMECHANICS, 39(12), 2264–2273.

By: Z. Li n & C. Kleinstreuer n

author keywords: stented abdominal aortic aneurysm; stent-graft migration; blood flow; stent-graft and aneurysm-wall interactions; computational parametric sensitivity analyses
TL;DR: Simulation results indicate that implanting a SG can significantly reduce sac pressure, mechanical stress, pulsatile wall motion, and maximum diameter change in AAAs; hence, it may restore normal blood flow and prevent AAA rupture effectively. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Computational analysis of type II endoleaks in a stented abdominal aortic aneurysm model

JOURNAL OF BIOMECHANICS, 39(14), 2573–2582.

By: Z. Li n & C. Kleinstreuer n

author keywords: abdominal aortic aneurysm; stent-graft; type II endoleaks; computational fluid-structure interaction analysis; sac pressure; wall stress; estimation of aneurysm-rupture risk; theoretical stent-graft migration
MeSH headings : Algorithms; Aorta, Abdominal / physiopathology; Aorta, Abdominal / surgery; Aortic Aneurysm, Abdominal / physiopathology; Aortic Aneurysm, Abdominal / surgery; Biomechanical Phenomena; Blood Flow Velocity / physiology; Blood Pressure / physiology; Blood Viscosity; Computer Simulation; Hematocrit; Humans; Models, Cardiovascular; Postoperative Complications / etiology; Postoperative Complications / physiopathology; Pressure; Stents / adverse effects; Stress, Mechanical; Vascular Surgical Procedures / adverse effects
TL;DR: Simulation results indicate that the sac pressure caused by types IIa and IIb endoleaks depends largely on the inlet branch pressure, where the branch inlet pressure increases, the sacpressure may reach the systemic level and AAA-rupture is possible. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Effects of blood flow and vessel geometry on wall stress and rupture risk of abdominal aortic aneurysms

Journal of Medical Engineering & Technology, 30(5), 283–297.

By: Z. Li & C. Kleinstreuer n

MeSH headings : Aorta, Abdominal / physiopathology; Aortic Aneurysm, Abdominal / physiopathology; Blood Pressure; Computer Simulation; Hemorheology; Humans; Models, Cardiovascular; Regional Blood Flow; Stress, Mechanical
TL;DR: It turned out that the AAA morphology plays an important role in wall deformation and stress distribution, and hence possible rupture, and the rupture risk of lateral asymmetric AAAs is higher than for the anterior – posterior asymmetric types. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: February 24, 2020

2006 journal article

Effects of major endoleaks on a stented abdominal aortic aneurysm

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 128(1), 59–68.

By: Z. Li n & C. Kleinstreuer n

author keywords: abdominal aortic aneurysm; stent-graft; type I endoleaks; computational analysis; sac pressure; hypertension; aneurysm rupture risk; stent-graft migration; wall stress
MeSH headings : Aorta, Abdominal / physiopathology; Aorta, Abdominal / surgery; Aortic Aneurysm, Abdominal / complications; Aortic Aneurysm, Abdominal / physiopathology; Aortic Aneurysm, Abdominal / surgery; Blood Flow Velocity; Blood Loss, Surgical / prevention & control; Blood Pressure; Blood Vessel Prosthesis / adverse effects; Computer Simulation; Humans; Models, Cardiovascular; Postoperative Hemorrhage / etiology; Postoperative Hemorrhage / physiopathology; Shear Strength; Stents / adverse effects; Stress, Mechanical; Treatment Outcome
TL;DR: Interestingly enough, the net downward force acting on the implant is significantly reduced; thus, in the presence of endoleaks, the risk of stent-graft migration may be mitigated, and both proximaltype I-a and distal type I-b endoleak may cause cavity pressures close to a patient's systemic pressure; however, with reduced pulsatility. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Isotonic and hypertonic saline droplet deposition in a human upper airway model

JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG, 19(2), 184–198.

By: Z. Zhang n, C. Kleinstreuer n & C. Kim*

author keywords: aerosol deposition; computational fluid-particle dynamics; droplet vaporization and hygroscopicity; isotonic and hypertonic saline droplets
MeSH headings : Administration, Inhalation; Humans; Humidity; Isotonic Solutions / pharmacokinetics; Lung / physiology; Models, Anatomic; Models, Biological; Particle Size; Respiratory Mechanics; Saline Solution, Hypertonic / pharmacokinetics; Thermodynamics; Volatilization; Wettability
TL;DR: The validated computer simulation results indicate that the increase of NaCl-solute concentration, increase of inlet relative humidity, or decrease of inlets air temperature may reduce water evaporation and increase water condensation at saline droplet surfaces, resulting in higher droplet depositions due to the increasing particle diameter and density. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Laminar airflow and nanoparticle or vapor deposition in a human nasal cavity model

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 128(5), 697–706.

By: H. Shi n, C. Kleinstreuer n & Z. Zhang n

MeSH headings : Absorption; Aerosols / pharmacokinetics; Air Movements; Computer Simulation; Gases / pharmacokinetics; Humans; Male; Middle Aged; Models, Biological; Nanoparticles; Nasal Cavity / metabolism; Tissue Distribution
TL;DR: An equation for a matching steady-state inhalation flow rate was developed that generates the same deposition results as cyclic inhalation in the olfactory region where the narrow channel surfaces receive only about one-half of a percent of the inhaled nanoparticles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Transport and uptake of MTBE and ethanol vapors in a human upper airway model

INHALATION TOXICOLOGY, 18(3), 169–184.

By: Z. Zhang n, C. Kleinstreuer n & C. Kim*

MeSH headings : Absorption; Biological Transport; Ethanol / pharmacokinetics; Humans; Methyl Ethers / pharmacokinetics; Mouth Mucosa / metabolism; Respiratory System / metabolism; Trachea / metabolism; Volatilization
TL;DR: Numerically the transport and deposition of MTBE and ethanol vapors in a model of the human upper respiratory airway, consisting of an oral airway and the first four generations of the tracheobronchial tree, is analyzed and the deposition dose may be reasonably estimated by a functional relationship with dimensionless fluid flow and diffusion parameters. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Water vapor transport and its effects on the deposition of hygroscopic droplets in a human upper airway model

AEROSOL SCIENCE AND TECHNOLOGY, 40(1), 1–16.

By: Z. Zhang n, C. Kleinstreuer n & C. Kim*

TL;DR: The fundamentals of 3-D airflow as well as heat and water vapor transport and droplet vaporization (or hygroscopicity) and deposition of isotonic saline droplets have been described and the effects of inhalation flow rates and thermodynamic air properties are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

A new wall stress equation for aneurysm-rupture prediction

ANNALS OF BIOMEDICAL ENGINEERING, 33(2), 209–213.

By: Z. Li n & C. Kleinstreuer n

author keywords: Laplace structure equation; abdominal aortic aneurysm; semi-empirical wall stress equation; AAA-rupture prediction
MeSH headings : Animals; Aortic Aneurysm, Abdominal / pathology; Aortic Aneurysm, Abdominal / physiopathology; Aortic Rupture / pathology; Aortic Rupture / physiopathology; Blood Flow Velocity; Blood Pressure; Computer Simulation; Diagnosis, Computer-Assisted / methods; Elasticity; Humans; Models, Cardiovascular; Prognosis; Risk Assessment / methods; Risk Factors; Severity of Illness Index; Shear Strength; Stress, Mechanical
TL;DR: A semi-empirical equation for the peak AAA-wall stress has been developed and can be readily used for AAA-rupture predictions or can be integrated into more elaborate AAA-assessment models. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Analysis of surface roughness effects on heat transfer in micro-conduits

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 48(13), 2625–2634.

By: J. Koo n & C. Kleinstreuer n

author keywords: thermal flow; microchannels; microtubes; computational analyses microscale parameters dimensionless temperature profiles; Nusselt numbers
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Blood flow and structure interactions in a stented abdominal aortic aneurysm model

MEDICAL ENGINEERING & PHYSICS, 27(5), 369–382.

By: Z. Li n & C. Kleinstreuer n

author keywords: fluid-structure interaction; stented abdominal aortic aneurysm; endovascular graft; sac pressure; wall stress; drag force; EVG migration
MeSH headings : Algorithms; Aorta, Abdominal; Aortic Aneurysm, Abdominal / diagnosis; Aortic Aneurysm, Abdominal / pathology; Aortic Rupture; Biophysical Phenomena; Biophysics; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Hemodynamics; Humans; Hypertension; Models, Anatomic; Models, Cardiovascular; Models, Statistical; Models, Theoretical; Pressure; Time Factors
TL;DR: The validated numerical results show that a securely placed EVG shields the diseased AAA wall from the pulsatile blood pressure and hence keeps the maximum wall stress 20 times below the wall stress value in the non-stented AAA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Comparison of micro- and nano-size particle depositions in a human upper airway model

JOURNAL OF AEROSOL SCIENCE, 36(2), 211–233.

By: Z. Zhang n, C. Kleinstreuer n, J. Donohue* & C. Kim*

author keywords: microparticle deposition; nanoparticle deposition; human upper airways; computational fluid-particle dynamics
TL;DR: Simulation results of microparticle and nanoparticle deposition patterns, local concentrations, and segmental averages are contrasted for a human upper airway model starting from the mouth to planar airway generation G3 under different inspiratory flow conditions to demonstrate uniformly deposited nanoparticles of similar concentrations may have greater toxicity effects when compared to microparticles of the same material. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Computational analysis of biomechanical contributors to endovascular graft failure

BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, 4(4), 221–234.

By: Z. Li n, C. Kleinstreuer n & M. Farber*

MeSH headings : Animals; Aorta, Abdominal / injuries; Aorta, Abdominal / physiopathology; Aortic Aneurysm, Abdominal / complications; Aortic Aneurysm, Abdominal / physiopathology; Aortic Aneurysm, Abdominal / surgery; Biomechanical Phenomena / methods; Blood Flow Velocity / physiology; Blood Vessel Prosthesis / adverse effects; Computer Simulation; Elasticity; Equipment Failure Analysis; Humans; Mechanotransduction, Cellular; Models, Cardiovascular; Prosthesis Failure; Rupture; Shear Strength; Stress, Mechanical; Viscosity
TL;DR: After EVG insertion for the given model, the peak AAA sac-pressure was reduced, and hence the maximum von Mises wall stress and wall deformation dropped by factors of 20 and 10, respectively, and an EVG can significantly reduce sac pressure, mechanical stress, pulsatile wall motion, and the maximum diameter in AAAs and hence prevent AAA rupture effectively. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Computational models for simulating multicomponent aerosol evaporation in the upper respiratory airways

AEROSOL SCIENCE AND TECHNOLOGY, 39(2), 124–138.

By: P. Longest* & C. Kleinstreuer n

TL;DR: Results indicate that a semiempirical evaporation model in conjunction with the identified surrogate mixture provide a computationally efficient method for computing droplet evapolation that can track individual toxic markers. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Fluid-structure interaction effects on sac-blood pressure and wall stress in a stented aneurysm

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 127(4), 662–671.

By: Z. Li n & C. Kleinstreuer n

author keywords: stented aneurysm; computational fluid-structure interaction simulations; abdominal aortic aneurysm; sac pressure; wall stress
MeSH headings : Animals; Aorta, Abdominal / physiopathology; Aorta, Abdominal / surgery; Aortic Aneurysm, Abdominal / complications; Aortic Aneurysm, Abdominal / physiopathology; Aortic Aneurysm, Abdominal / surgery; Aortic Rupture / etiology; Aortic Rupture / physiopathology; Blood Flow Velocity; Blood Pressure; Blood Vessel Prosthesis; Computer Simulation; Humans; Models, Cardiovascular; Stents; Stress, Mechanical
TL;DR: Simulation results indicate that, even without the presence of endoleaks (blood flowing into the cavity), elevated sac pressure can occur due to complex fluid-structure interactions between the luminal blood flow, EVG wall, intra-sac stagnant blood, including an intra-luminal thrombus, and the aneurysm wall. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Laminar nanofluid flow in microheat-sinks

International Journal of Heat and Mass Transfer, 48(13), 2652–2661.

By: J. Koo & C. Kleinstreuer

Source: NC State University Libraries
Added: August 6, 2018

2005 article

Numerical simulation of wall shear stress and particle-based hemodynamic parameters in pre-cuffed and streamlined end-to-side anastomoses

Longest, P. W., Kleinstreuer, C., & Deanda, A. (2005, December). ANNALS OF BIOMEDICAL ENGINEERING, Vol. 33, pp. 1752–1766.

By: P. Longest*, C. Kleinstreuer n & A. Deanda*

author keywords: particle hemodynamics; hemodynamic wall parameters; near-wall residence time; femoropopliteal bypass; end-to-side anastomosis; intimal hyperplasia; pre-cuffed grafts; streamlined grafts
MeSH headings : Anastomosis, Surgical / adverse effects; Blood Vessel Prosthesis / adverse effects; Blood Vessel Prosthesis Implantation / adverse effects; Blood Vessels / physiopathology; Hemodynamics; Humans; Hyperplasia; Imaging, Three-Dimensional; Models, Cardiovascular; Nanostructures; Stress, Mechanical; Tunica Intima / pathology; Tunica Intima / physiopathology
TL;DR: It was found that a pre-cuffed anastomosis does not offer a hemodynamic advantage over the conventional design considered with respect to the magnitude of the WSS field and the potential for platelet interactions with the vessel surface, highlighting the difficulty associated with designing an end-to-side distal anASTomosis with two-way outflow that is capable of simultaneously reducing multiple hemodynamic parameters. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 journal article

A new thermal conductivity model for nanofluids

JOURNAL OF NANOPARTICLE RESEARCH, 6(6), 577–588.

By: J. Koo* & C. Kleinstreuer*

author keywords: nanofluids; effective thermal conductivity; apparent thermal conductivity; Brownian motion; interparticle potential; modeling and simulation
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Airflow structures and nano-particle deposition in a human upper airway model

JOURNAL OF COMPUTATIONAL PHYSICS, 198(1), 178–210.

By: Z. Zhang n & C. Kleinstreuer n

author keywords: inspiratory flow; nano-size particle deposition; human airways; computational fluid-particle dynamics simulation
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Computational analysis of wall roughness effects for liquid flow in micro-conduits

Journal of Fluids Engineering, 126(1), 09-.

By: C. Kleinstreuer & J. Koo

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Efficient computation of micro-particle dynamics including wall effects

COMPUTERS & FLUIDS, 33(4), 577–601.

By: P. Longest n, C. Kleinstreuer n & . Buchanan n

TL;DR: The near-wall residence time (NWRT) model indicating the probability of blood particle deposition is presented and the proposed particle tracking algorithm stores all transient velocity field solution data on a shared memory architecture and computes particle trajectories using an adaptive parallel approach. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Interacting effects of uniform flow, plane shear, and near-wall proximity on the heat and mass transfer of respiratory aerosols

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 47(22), 4745–4759.

By: P. Longest* & C. Kleinstreuer n

author keywords: droplet heat and mass transfer; respiratory aerosols; near-wall droplet evaporation; droplet Nusselt and Sherwood number correlations
TL;DR: Multivariable Sherwood and Nusselt number correlations can be applied to effectively compute condensation and evaporation rates of potentially toxic or therapeutic aerosols in the upper respiratory tract, where non-uniform flow and wall proximity are expected to significantly affect droplet transport, deposition, and vapor formation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Nanoparticle transport and deposition in bifurcating tubes with different inlet conditions

PHYSICS OF FLUIDS, 16(7), 2199–2213.

By: H. Shi n, C. Kleinstreuer n, Z. Zhang n & C. Kim*

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Particle-hemodynamics simulations and design options for surgical reconstruction of diseased carotid artery bifurcations

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 126(2), 188–195.

By: S. Hyun*, C. Kleinstreuer n, P. Longest n & C. Chen n

MeSH headings : Blood Flow Velocity; Blood Pressure; Carotid Artery Diseases / physiopathology; Carotid Artery Diseases / surgery; Computer Simulation; Endarterectomy, Carotid; Hemorheology / methods; Humans; Models, Cardiovascular; Particle Size; Risk Assessment; Surgery, Computer-Assisted / methods
TL;DR: The methodology of "virtual prototyping" of branching blood vessels was applied to diseased external carotid artery segments to understand the underlying particle-hemodynamics and to provide various geometric design options for improved surgical reconstruction based on the minimization of critical hemodynamic wall parameters. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Vaporizing Microdroplet Inhalation, Transport, and Deposition in a Human Upper Airway Model

Aerosol Science and Technology, 38(1), 36–49.

By: Z. Zhang, C. Kleinstreuer*, C. Kim & Y. Cheng

Source: Crossref
Added: February 24, 2020

2004 journal article

Vaporizing microdroplet inhalation, transport, and deposition in a human upper airway model

AEROSOL SCIENCE AND TECHNOLOGY, 38(1), 36–49.

By: Z. Zhang*, C. Kleinstreuer*, C. Kim & Y. Cheng

Source: Web Of Science
Added: August 6, 2018

2004 journal article

Viscous dissipation effects in microtubes and microchannels

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 47(14-16), 3159–3169.

By: J. Koo n & C. Kleinstreuer n

author keywords: viscous dissipation; microchannel; microtube; computational analyses; dimensionless groups; temperature distributions; friction factor
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Comparison of blood particle deposition models for non-parallel flow domains

JOURNAL OF BIOMECHANICS, 36(3), 421–430.

By: P. Longest n & C. Kleinstreuer n

author keywords: particle-hemodynamics; monocytes; platelets; deposition; adhesion; computational fluid-particle dynamics; near-wall residence time
MeSH headings : Animals; Blood Flow Velocity; Blood Platelets / physiology; Blood Vessels / physiology; Cell Adhesion / physiology; Computer Simulation; Hemorheology / methods; Humans; Models, Cardiovascular; Monocytes / physiology; Particle Size; Platelet Adhesiveness / physiology; Rheology / methods; Sensitivity and Specificity; Shear Strength; Stress, Mechanical
TL;DR: Factors including the convective-diffusive transport of particles, finite particle size and inertia, as well as near-wall hydrodynamic interactions were found to significantly influence blood particle deposition. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 article

Computational thermodynamics analysis of vaporizing fuel droplets in the human upper airways

Zhang, Z., & Kleinstreuer, C. (2003, November). JSME INTERNATIONAL JOURNAL SERIES B-FLUIDS AND THERMAL ENGINEERING, Vol. 46, pp. 563–571.

By: Z. Zhang n & C. Kleinstreuer n

author keywords: liquid aerosol transport and deposition; JP-8 fuel; human airways; heat and mass transfer
TL;DR: Focusing on highly toxic JP-8 fuel aerosols, 3-D airflow and fluid-particle thermodynamics in a human upper airway model, the computational results show that the thermal effect on vapor deposition is minor, but it may greatly affect droplet deposition in human airways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Hemodynamics simulation and identification of susceptible sites of atherosclerotic lesion formation in a model abdominal aorta

JOURNAL OF BIOMECHANICS, 36(8), 1185–1196.

By: . Buchanan n, C. Kleinstreuer n, S. Hyun* & G. Truskey*

author keywords: computational blood flow simulation; rabbit aorta; atherosclerotic model; hemodynamic wall parameters; monocyte deposition; experimental data comparisons
MeSH headings : Animals; Aorta, Abdominal / pathology; Aorta, Abdominal / physiopathology; Blood Flow Velocity; Blood Pressure; Cell Adhesion / physiology; Cell Aggregation / physiology; Cell Movement / physiology; Computer Simulation; Coronary Artery Disease / pathology; Coronary Artery Disease / physiopathology; Elasticity; Endothelium, Vascular / physiology; Hemorheology / methods; Models, Cardiovascular; Monocytes / physiology; Physical Conditioning, Animal / physiology; Pulsatile Flow / physiology; Rabbits; Shear Strength
TL;DR: The results suggest that the transport and deposition pattern of monocytes to arterial endothelium plays a significant role in the localization of lesions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Laminar-to-turbulent fluid-particle flows in a human airway model

INTERNATIONAL JOURNAL OF MULTIPHASE FLOW, 29(2), 271–289.

By: C. Kleinstreuer n & Z. Zhang n

author keywords: computational gas-solid two-phase flow; internal laminar-to-turbulent flow modeling; micro-particle distributions; human oral airway
TL;DR: The laminar-to-turbulent suspension flow problem was solved for a human airway model using a commercial software with user-supplied pre- and post-processing programs and the methodology outlined can be readily applied to other two-phase flows undergoing changing flow regimes in complex tubular systems. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Liquid flow in microchannels: experimental observations and computational analyses of microfluidics effects

JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 13(5), 568–579.

By: J. Koo n & C. Kleinstreuer n

Source: Web Of Science
Added: August 6, 2018

2003 journal article

Low-Reynolds-number turbulent flows in locally constricted conduits: A comparison study

AIAA JOURNAL, 41(5), 831–840.

By: Z. Zhang n & C. Kleinstreuer n

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Numerical simulation of wall shear stress conditions and platelet localization in realistic end-to-side arterial anastomoses

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 125(5), 671–681.

By: P. Longest n & C. Kleinstreuer n

MeSH headings : Anastomosis, Surgical; Animals; Arteries / physiopathology; Arteries / surgery; Blood Flow Velocity; Blood Pressure; Cell Movement; Computer Simulation; Hemorheology / methods; Humans; Models, Cardiovascular; Platelet Activation; Platelet Adhesiveness; Shear Strength; Surface Properties
TL;DR: The potential significance of platelet-wall interactions coinciding with regions of low WSS in the development of IH is indicated, as large variations in WSS-vector magnitude and direction were consistently observed along the IH-prone suture-line region. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Particle hemodynamics analysis of Miller cuff arterial anastomosis

JOURNAL OF VASCULAR SURGERY, 38(6), 1353–1362.

By: P. Longest n, C. Kleinstreuer n & J. Archie n

MeSH headings : Anastomosis, Surgical / adverse effects; Anastomosis, Surgical / instrumentation; Blood Flow Velocity / physiology; Endothelium, Vascular / pathology; Endothelium, Vascular / physiopathology; Femoral Artery / physiopathology; Femoral Artery / surgery; Humans; Hyperplasia / etiology; Hyperplasia / physiopathology; Models, Cardiovascular; Popliteal Artery / physiopathology; Popliteal Artery / surgery; Shear Strength; Vascular Patency / physiology; Vascular Resistance / physiology
TL;DR: The results imply that particle hemodynamics conditions engendered by Miller cuff geometry provide a mechanism that may account for redistribution of intimal hyperplasia. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Particle-hemodynamics modeling of the distal end-to-side femoral bypass: effects of graft caliber and graft-end cut

MEDICAL ENGINEERING & PHYSICS, 25(10), 843–858.

By: P. Longest n & C. Kleinstreuer n

author keywords: particle-hemodynamics; hemodynamic wall parameters; near-wall residence time; femoropopliteal bypass; end-to-side anastomosis; intimal hyperplasia
MeSH headings : Anastomosis, Surgical; Arteries / pathology; Blood Flow Velocity; Blood Platelets / metabolism; Blood Vessel Prosthesis; Femoral Artery / pathology; Femoral Vein / pathology; Humans; Hyperplasia; Models, Anatomic; Models, Cardiovascular; Models, Theoretical; Platelet Activation; Stress, Mechanical; Thrombosis
TL;DR: The results illustrate the need for alternative anastomotic designs with the intent of reducing critical hemodynamic wall parameters and mitigating regions of significant particle-wall interactions at locations critical to flow delivery. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Relation between near-wall residence times of monocytes and early lesion growth in the rabbit aorto-celiac junction

ANNALS OF BIOMEDICAL ENGINEERING, 31(1), 53–64.

By: P. Longest n, C. Kleinstreuer n, G. Truskey* & . Buchanan*

author keywords: atherosclerosis; particle hemodynamics; hemodynamic wall parameters; monocytes; adhesion; deposition; computational fluid dynamics; near-wall residence time
MeSH headings : Animals; Aorta, Abdominal / physiopathology; Arteriosclerosis / physiopathology; Blood Flow Velocity; Blood Physiological Phenomena; Blood Pressure; Celiac Artery / physiopathology; Cell Adhesion; Computer Simulation; Hemorheology / methods; Models, Cardiovascular; Monocytes; Particle Size; Rabbits; Shear Strength; Stress, Mechanical
TL;DR: Results indicate that cell transport and conditions for hemodyamically induced surface reactivity are necessary components in formulating an effective model for monocyte adhesion in complex three-dimensional vessel configurations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Species heat and mass transfer in a human upper airway model

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 46(25), 4755–4768.

By: Z. Zhang n & C. Kleinstreuer n

TL;DR: Steady 3-D airflow and scalar transport of ultrafine particles, d p Q in, ambient temperature variations influence the local velocity fields and vapor concentrations, but the total and segmental deposition fractions of fuel vapor in the upper airway are essentially unaffected. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Targeted drug aerosol deposition analysis for a four-generation lung airway model with hemispherical tumors

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 125(2), 197–206.

By: C. Kleinstreuer n & Z. Zhang n

MeSH headings : Administration, Inhalation; Adsorption; Aerosols / administration & dosage; Aerosols / pharmacokinetics; Aerosols / therapeutic use; Bronchi / drug effects; Bronchi / metabolism; Bronchi / physiopathology; Bronchial Neoplasms / drug therapy; Bronchial Neoplasms / metabolism; Bronchial Neoplasms / physiopathology; Computer Simulation; Drug Delivery Systems / methods; Drug Therapy, Computer-Assisted / methods; Finite Element Analysis; Lung / drug effects; Lung / metabolism; Lung / physiopathology; Models, Biological; Particle Size; Pulsatile Flow; Rheology / methods; Sensitivity and Specificity
TL;DR: The concept of "controlled particle release and targeting" is introduced and results are discussed for a representative model of bronchial lung airways afflicted with hemispherical tumors of different sizes and locations, using a validated commercial finite-volume code with user-enhanced programs on a high-end engineering workstation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Acoustic streaming induced by ultrasonic flexural vibrations and associated enhancement of convective heat transfer

JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 111(2), 875–883.

By: B. Loh n, S. Hyun n, P. Ro n & C. Kleinstreuer n

MeSH headings : Acoustics; Hot Temperature; Models, Theoretical; Ultrasonics; Vibration
TL;DR: Acoustic streaming induced by ultrasonic flexural vibrations and the associated convection enhancement are investigated and it is observed that the streaming velocity decreases with the excitation frequency, and with an open-ended channel, a substantial increase in streaming velocity is observed from CFD simulations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Aerosol deposition efficiencies and upstream release positions for different inhalation modes in an upper bronchial airway model

AEROSOL SCIENCE AND TECHNOLOGY, 36(7), 828–844.

By: Z. Zhang, C. Kleinstreuer* & C. Kim

TL;DR: The detailed results show particle deposition patterns and efficiencies in the triple bifurcation under cyclic as well as steady-state inhalation conditions, and particle maps were developed that show the release positions of deposited aerosols. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Aerosol transport and deposition in a triple bifurcation bronchial airway model with local tumors

INHALATION TOXICOLOGY, 14(11), 1111–1133.

By: Z. Zhang*, C. Kleinstreuer*, C. Kim* & A. Hickey*

MeSH headings : Administration, Inhalation; Aerosols / administration & dosage; Aerosols / pharmacokinetics; Airway Obstruction / pathology; Airway Obstruction / physiopathology; Biological Availability; Bronchi / metabolism; Computer Simulation; Humans; Models, Anatomic; Models, Biological; Neoplasms / metabolism; Neoplasms / pathology; Particle Size; Pulmonary Ventilation
TL;DR: The results show that enhanced deposition occurs in the carina region at each bifurcation, and deposition increases with increasing Stokes and Reynolds number as expected from earlier studies, and there exists a maximum particle deposition fraction for a protruding tumor that occludes the lumen. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Cyclic micron-size particle inhalation and deposition in a triple bifurcation lung airway model

JOURNAL OF AEROSOL SCIENCE, 33(2), 257–281.

By: Z. Zhang*, C. Kleinstreuer n & C. Kim*

author keywords: cyclic inhalation; particle deposition; symmetric triple bifurcation; computational fluid-particle dynamics; simulations
TL;DR: The quantitative results of this work are of interest to researchers either conducting health risk assessment studies for inhaled particulate pollutants or analyzing drug aerosol deposition at desired lung target sites. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Gas-solid two-phase flow in a triple bifurcation lung airway model

INTERNATIONAL JOURNAL OF MULTIPHASE FLOW, 28(6), 1021–1046.

By: Z. Zhang*, C. Kleinstreuer* & C. Kim*

author keywords: large bronchial airways; aerosol transport and deposition; computational two-phase flow
TL;DR: Comparisons of DEs among different lung generations or bifurcation areas for both cyclic inhalation and exhalation show that DEs in the third b ifurcation region may be quite different from those at previous bifURcations due to upstream geometry and flow effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Micro-particle transport and deposition in a human oral airway model

JOURNAL OF AEROSOL SCIENCE, 33(12), 1635–1652.

By: Z. Zhang n, C. Kleinstreuer n & C. Kim*

author keywords: human oral airway; laminar-to-turbulent airflow; particle deposition; computational fluid-particle dynamics simulations
TL;DR: The present model may serve as the “entryway” for simulating and analyzing airflow and particle deposition in the lung, and exhibit the main features of laminar-transitional-turbulent particle suspension flows in actual human oral airways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Transient airflow structures and particle transport in a sequentially branching lung airway model

Physics of Fluids (Woodbury, N.Y.), 14(2), 862–880.

By: Z. Zhang* & C. Kleinstreuer n

UN Sustainable Development Goal Categories
Source: NC State University Libraries
Added: August 6, 2018

2001 article

'Effects of asymmetric branch flow rates on aerosol deposition in bifurcating airways', by Z. Zhang, C. Kleinstreuer and C. S. Kim - Response

JOURNAL OF MEDICAL ENGINEERING & TECHNOLOGY, Vol. 25, pp. 127–127.

By: C. Kleinstreuer n

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 journal article

A New Near-wall Residence Time Model Applied to Three Arterio-venous Graft End-to-side Anastomoses

Computer Methods in Biomechanics and Biomedical Engineering, 4(5), 379–397.

By: P. Longest n, C. Kleinstreuer n & J. Buchanan n

TL;DR: It is concluded from this study that for the application of looped arterio-venous grafts, the graft-end geometry and the presence of retrograde outflow significantly influence the magnitude and location of the hemodynamic wall parameters considered. (via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities (OpenAlex)
Source: Crossref
Added: August 28, 2020

2001 journal article

Computational particle-hemodynamics analysis and geometric reconstruction after carotid endarterectomy

COMPUTERS IN BIOLOGY AND MEDICINE, 31(5), 365–384.

By: S. Hyun n, C. Kleinstreuer n & J. Archie n

author keywords: endarterectomized carotid artery; particle-hemodynamics simulations; indicator functions; surgical reconstruction geometries
MeSH headings : Carotid Stenosis / pathology; Carotid Stenosis / physiopathology; Carotid Stenosis / surgery; Computer Simulation; Endarterectomy, Carotid / adverse effects; Endarterectomy, Carotid / methods; Endarterectomy, Carotid / statistics & numerical data; Hemodynamics; Humans; Models, Cardiovascular; Postoperative Complications / prevention & control; Stroke / prevention & control
TL;DR: The new carotid artery bifurcation design is based on the overall reduction of "disturbed flow" indicator functions, including the time-averaged wall shear stress angle deviation and a wall deposition parameter for critical blood particles, such as monocytes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Effect of particle inlet distributions on deposition in a triple bifurcation lung airway model

JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG, 14(1), 13–29.

By: Z. Zhang* & C. Kleinstreuer n

author keywords: aerosol deposition; random particle release conditions; computational fluid-particle dynamics; deposition efficiencies
MeSH headings : Administration, Inhalation; Aerosols / administration & dosage; Aerosols / pharmacokinetics; Biological Availability; Computer Simulation; Humans; Lung / physiology; Models, Anatomic; Particle Size; Respiratory Mechanics; Respiratory Physiological Phenomena; Sensitivity and Specificity
TL;DR: According to the simulation validations, a determinstic parabolic distribution of inlet particles may be sufficient for laboratory data comparison purposes, but random distributions should reflect realistic environmental or medical aerosol inhalation more accurately. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Effects of curved inlet tubes on air flow and particle deposition in bifurcating lung models

JOURNAL OF BIOMECHANICS, 34(5), 659–669.

By: Z. Zhang*, C. Kleinstreuer* & C. Kim*

author keywords: double airway bifurcations; bent parent tubes; uniform and parabolic inlet velocity profiles; aerosol transport and deposition; computational parametric sensitivity analyses
MeSH headings : Biomechanical Phenomena; Humans; Lung / anatomy & histology; Lung / physiology; Models, Anatomic; Models, Biological; Respiratory Mechanics
TL;DR: St steady laminar dilute suspension flows of micron-particles are simulated in realistic double bifurcations with curved inlet tubes using a commercial finite-volume code with user-enhanced programs to provide necessary information for toxicologic or therapeutic impact assessments and for global lung dosimetry models of inhaled particulate matter. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 article

Flow structure and particle transport in a triple bifurcation airway model

Zhang, Z., Kleinstreuer, C., & Kim, C. S. (2001, June). JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME, Vol. 123, pp. 320–330.

By: Z. Zhang*, C. Kleinstreuer n & C. Kim*

UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Flow structures and particle deposition patterns in double-bifurcation airway models. Part 1. Air flow fields

JOURNAL OF FLUID MECHANICS, 435, 25–54.

By: J. Comer n, C. Kleinstreuer n & Z. Zhang*

TL;DR: The theory, model geometries, and air flow results are provided and detailed results for bifurcating lung airways are most useful in the development of global algebraic lung models. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Flow structures and particle deposition patterns in double-bifurcation airway models. Part 2. Aerosol transport and deposition

JOURNAL OF FLUID MECHANICS, 435, 55–80.

By: J. Comer n, C. Kleinstreuer* & C. Kim*

TL;DR: The flow theory and air flow structures in symmetric double-bifurcation airway models assuming steady laminar, incompressible flow, unaffected by the presence of aerosols, and the history of depositing particles is described are described. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Hemodynamic parameters and early intimal thickening in branching blood vessels

Critical Reviews in Biomedical Engineering, 29(1), 1–64.

By: C. Kleinstreuer n, S. Hyun n, J. Buchanan n, P. Longest n, J. Archie* & G. Truskey*

MeSH headings : Animals; Arteriosclerosis / physiopathology; Biological Transport; Carotid Arteries / physiology; Carotid Arteries / physiopathology; Compliance; Endothelium, Vascular / pathology; Endothelium, Vascular / physiopathology; Hemodynamics; Humans; Hyperplasia; Hypertension / physiopathology; Models, Cardiovascular; Muscle, Smooth, Vascular / pathology; Muscle, Smooth, Vascular / physiopathology; Pulsatile Flow / physiology; Stress, Mechanical; Tunica Intima / pathology; Tunica Intima / physiopathology; Vascular Cell Adhesion Molecule-1 / metabolism
TL;DR: The focus is on the identification of susceptible sites in branching blood vessels and their subsequent redesign, employing hemodynamic wall parameters that indicate susceptible sites of intimal thickening and/or favorable conditions for thrombi formation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Numerical simulation of mixed convection heat and mass transfer in a human inhalation test chamber

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 44(12), 2247–2260.

By: S. Hyun n & C. Kleinstreuer n

UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities (OpenAlex)
13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Aerosol transport and deposition in sequentially bifurcating airways

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 122(2), 152–158.

By: J. Comer n, C. Kleinstreuer n, S. Hyun n & C. Kim*

MeSH headings : Aerosols; Biomedical Engineering; Computer Simulation; Humans; Models, Anatomic; Models, Biological; Particle Size; Respiratory Mechanics; Respiratory Physiological Phenomena; Respiratory System / anatomy & histology
TL;DR: The use of single bifurcation models was determined to be inadequate to resolve the complex fluid-particle interactions that occur in multigenerational airways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 article

Computational analyses and design improvements of graft-to-vein anastomoses

CRITICAL REVIEWS IN BIOMEDICAL ENGINEERING, Vol. 28, pp. 141–147.

By: P. Longest n, C. Kleinstreuer n & P. Andreotti

author keywords: hemodialysis; graft failure; hemodynamic simulations; geometric designs
MeSH headings : Arteriovenous Shunt, Surgical / methods; Blood Flow Velocity; Computer Simulation; Hemodynamics; Humans; Models, Cardiovascular; Renal Dialysis / methods
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Computational haemodynamics analysis and comparison study of arterio-venous grafts

Journal of Medical Engineering & Technology, 24(3), 102–110.

By: P. Longest & C. Kleinstreuer

Source: NC State University Libraries
Added: August 6, 2018

2000 article

Computer simulation and geometric design of endarterectomized carotid artery bifurcations

CRITICAL REVIEWS IN BIOMEDICAL ENGINEERING, Vol. 28, pp. 53–59.

By: S. Hyun n, C. Kleinstreuer n & J. Archie*

author keywords: branching blood vessels; arterial diseases; particle-hemodynamics; numerical analysis
MeSH headings : Blood Flow Velocity; Carotid Arteries / anatomy & histology; Carotid Arteries / surgery; Computer Simulation; Endarterectomy, Carotid; Humans; Models, Cardiovascular
TL;DR: This computational study established surgical guidelines for optimal geometries of carotid endarterectomy reconstructions that may measurably reduce postoperative complications, that is, thrombosis, stroke, and/or restenosis, based on the underlying hypotheses that nonuniform hemodynamics, or "disturbed flows," are linked to arterial diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Effects of asymmetric branch flow rates on aerosol deposition in bifurcating airways

Journal of Medical Engineering & Technology, 24(5), 192–202.

By: Z. Zhang, C. Kleinstreuer & C. Kim

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Hemodynamics analyses of arterial expansions with implications to thrombosis and restenosis

MEDICAL ENGINEERING & PHYSICS, 22(1), 13–27.

By: S. Hyun n, C. Kleinstreuer n & J. Archie n

author keywords: computational hemodynamics simulations; transient particle-hemodynamics; sudden and smooth expansions; arterial disease indicators; thrombosis; restenosis
MeSH headings : Arteries / pathology; Arteries / physiopathology; Carotid Artery, Common / pathology; Carotid Artery, Common / physiopathology; Endarterectomy, Carotid / adverse effects; Hemodynamics; Humans; Models, Cardiovascular; Postoperative Complications / etiology; Postoperative Complications / pathology; Postoperative Complications / physiopathology; Stress, Mechanical; Thrombosis / etiology; Thrombosis / pathology; Thrombosis / physiopathology
TL;DR: The regions near the expansion wall and the reattachment point are susceptible to both atherosclerotic lesion and thrombi formations as indicated by non-uniform hemodynamic indicators as well as blood particle accumulation and deposition. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Rheological effects on pulsatile hemodynamics in a stenosed tube

COMPUTERS & FLUIDS, 29(6), 695–724.

By: . Buchanan n, C. Kleinstreuer n & J. Comer n

author keywords: stenosis; transient flow; non-Newtonian fluids; particle residence times; hemodynamic wall parameter
TL;DR: The particle residence time (PRT), defined as the ratio of transient to steady residence times, is found to be less than or equal to unity for the majority of fluid elements for all rheologies and Womersley numbers considered. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 article

Turbulent three-dimensional air flow and trace gas distribution in an inhalation test chamber

Longest, P. W., Kleinstreuer, C., & Kinsey, J. S. (2000, June). JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME, Vol. 122, pp. 403–411.

By: P. Longest n, C. Kleinstreuer n & J. Kinsey*

TL;DR: Steady incompressible turbulent air flow and transient carbon monoxide transport in an empty Rochester-style human exposure chamber have been numerically simulated and compared with experimental data sets to determine the development of tracer gas distributions in the chamber and analyze the contributions to CO-mixing. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Relation between non-uniform hemodynamics and sites of altered permeability and lesion growth at the rabbit aorto-celiac junction

ATHEROSCLEROSIS, 143(1), 27–40.

By: . Buchanan n, C. Kleinstreuer n, G. Truskey* & M. Lei*

author keywords: computational simulation; aorto-celiac junction; hemodynamic parameters; enhanced wall permeability; WBC uptake; atherosclerotic lesion growth
MeSH headings : Animals; Aorta, Abdominal / pathology; Aorta, Abdominal / physiopathology; Aorta, Thoracic / physiopathology; Arteriosclerosis / pathology; Arteriosclerosis / physiopathology; Blood Flow Velocity; Capillary Permeability; Celiac Artery / pathology; Celiac Artery / physiopathology; Computer Simulation; Hemorheology; Leukocytes / physiology; Models, Cardiovascular; Rabbits; Stress, Mechanical
TL;DR: This study presents a rationale for further quantitative correlative studies in the rabbit model based on additional histological data sets and shows a statistically significant correlation between the wall shear stress (WSS), the oscillatory shear index (OSI), and the spatial wallShear stress gradient (W SSG). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Analytical solution to flux enhancement in laminar concentrically stratified pipe flow of Bingham and Newtonian fluids

JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME, 120(3), 629–631.

By: C. Buchanan n, C. Kleinstreuer n & P. Longest n

Source: Web Of Science
Added: August 6, 2018

1998 journal article

Simulation of particle-hemodynamics in a partially occluded artery segment with implications to the initiation of microemboli and secondary stenoses

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 120(4), 446–454.

By: . Buchanan n & C. Kleinstreuer n

MeSH headings : Algorithms; Arterial Occlusive Diseases / blood; Arterial Occlusive Diseases / complications; Arterial Occlusive Diseases / physiopathology; Humans; Models, Cardiovascular; Monocytes / physiology; Numerical Analysis, Computer-Assisted; Oscillometry; Platelet Count; Reproducibility of Results; Rheology; Stress, Mechanical; Thrombin / physiology; Thromboembolism / blood; Thromboembolism / etiology; Thromboembolism / physiopathology
TL;DR: Results of laminar incompressible blood-particle flow analyses in an axisymmetric artery segment with a smooth local area constriction of 75 percent have been presented and indicate sites susceptible to the onset of an additional stenosis proximal to the initial geometric disturbance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Computational design of a bypass graft that minimizes wall shear stress gradients in the region of the distal anastomosis

JOURNAL OF VASCULAR SURGERY, 25(4), 637–646.

By: M. Lei n, J. Archie & C. Kleinstreuer*

MeSH headings : Algorithms; Anastomosis, Surgical / adverse effects; Anastomosis, Surgical / methods; Arterial Occlusive Diseases / prevention & control; Arterial Occlusive Diseases / surgery; Arteries / pathology; Arteries / surgery; Arteriosclerosis / etiology; Computer Simulation; Constriction, Pathologic / prevention & control; Constriction, Pathologic / surgery; Hemodynamics; Hemorheology / classification; Humans; Hyperplasia; Models, Cardiovascular; Physical Exertion / physiology; Recurrence; Regional Blood Flow; Rest / physiology; Stress, Mechanical; Thrombosis / prevention & control; Tunica Intima / pathology
TL;DR: It is demonstrated that it is possible to design a terminal graft geometry for an end-to-side anastomosis that significantly reduces wall shear stress gradients, and this results may point to the design of optimal bypass graft geometries. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1997 book

Engineering fluid dynamics: An interdisciplinary systems approach

By: C. Kleinstreuer n

Source: NC State University Libraries
Added: August 6, 2018

1997 article

Hemodynamic simulations and computer aided designs of graft-artery junctions

Lei, M., Kleinstreuer, C., & Archie, J. P. (1997, August). JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol. 119, pp. 343–348.

By: M. Lei n, C. Kleinstreuer n & J. Archie n

MeSH headings : Algorithms; Anastomosis, Surgical / adverse effects; Animals; Arteries / physiopathology; Blood Flow Velocity; Blood Vessel Prosthesis / adverse effects; Computer Simulation; Computer-Aided Design; Constriction, Pathologic / etiology; Constriction, Pathologic / physiopathology; Femoral Artery / physiology; Femoral Artery / surgery; Hemodynamics / physiology; Humans; Models, Cardiovascular; Recurrence; Stress, Mechanical; Vascular Patency
TL;DR: The hypothesis is that nonuniform hemodynamics, represented by large sustained wall shear stress gradients, trigger abnormal biological processes leading to rapid restenosis and hence early graft failure, and this problem may be significantly mitigated by designing graft-artery bypass configurations for which the wallShear stress gradient is approximately zero and hence nearly uniform hemodynamics are achieved. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

journal article

Analysis and computer program for rupture-risk prediction of abdominal aortic aneurysms

Kleinstreuer, C., & Li, Z. H. Biomedical Engineering Online, 5.

By: C. Kleinstreuer & Z. Li

Source: NC State University Libraries
Added: August 6, 2018

book

Biofluid dynamics

Kleinstreuer, C. Boca Raton, FL: CRC/Taylor & Francis.

By: C. Kleinstreuer

Source: NC State University Libraries
Added: August 6, 2018

chapter

Computational analysis of enhanced cooling performance and pressure drop for nanofluid flow in microchannels

Kleinstreuer, C., Li, J., & Feng, Y. In E. M. W.J. Minkowycz, Sparrow, & J. P. Abraham (Eds.), Advanced in numerical heat transfer (pp. 250–273). Boca Raton: CRC Press/Taylor & Francis Group.

By: C. Kleinstreuer, J. Li & Y. Feng

Ed(s): E. W.J. Minkowycz, . Sparrow & J. Abraham

Source: NC State University Libraries
Added: August 6, 2018

journal article

Computational nanofluid flow and heat transfer in microchannels

Kleinstreuer, C. Handbook of Fluid Dynamics, 2nd Edition.

By: C. Kleinstreuer

Source: NC State University Libraries
Added: August 6, 2018

journal article

Entropy generation analysis for nanofluid flow in microchannels

Kleinstreuer, C. Journal of Heat Transfer, 132(12).

By: C. Kleinstreuer

Source: NC State University Libraries
Added: August 6, 2018

journal article

Microsystems and microfluidics

Kleinstreuer, C. Handbook of Fluid Dynamics, 2nd Edition.

By: C. Kleinstreuer

Source: NC State University Libraries
Added: August 6, 2018

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