Works (72)

Updated: April 15th, 2024 06:20

2024 journal article

Geographic disparities and predictors of COVID-19 vaccination in Missouri: a retrospective ecological study

FRONTIERS IN PUBLIC HEALTH, 12.

By: A. Lacy*, M. Khan*, N. Nath*, P. Das n, M. Igoe*, S. Lenhart*, A. Lloyd n, C. Lanzas n, A. Odoi*

author keywords: COVID-19; Missouri; spatial epidemiology; epidemiology; geographic disparities; predictors; vaccination
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024

2023 article

Distilling Mechanistic Models From Multi-Omics Data

Erwin, S., Fletcher, J. R., Sweeney, D. C., Theriot, C. M., & Lanzas, C. (2023, September 6).

TL;DR: A four-step analysis approach for multiomics data is demonstrated, comprising: filling missing data and harmonizing data sources, inducing sparsity, developing mechanistic models, and interpretation, which highlighted the role of the Stickland reactor in the production of toxins during infection. (via Semantic Scholar)
Source: ORCID
Added: September 7, 2023

2023 article

Early coronavirus disease 2019 (COVID-19) pandemic effects on individual-level risk for healthcare-associated infections in hospitalized patients

Farthing, T. S., Jolley, A., Nickel, K. B., Hill, C., Stwalley, D., Reske, K. A., … Lanzas, C. (2023, June 29). INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, Vol. 6.

By: T. Farthing n, A. Jolley n, K. Nickel*, C. Hill*, D. Stwalley*, K. Reske*, J. Kwon*, M. Olsen* ...

TL;DR: The results support the growing body of evidence indicating that the COVID-19 pandemic has increased hospital-onset MDRO infections. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 19, 2023

2023 journal article

Early evaluation of the Food and Drug Administration (FDA) guidance on antimicrobial use in food animals on antimicrobial resistance trends reported by the National Antimicrobial Resistance Monitoring System (2012-2019)

ONE HEALTH, 17.

By: L. Deb n, M. Jara n & C. Lanzas n

author keywords: Antimicrobial resistance; FDA; Growth promotion; Guidance; NARMS
TL;DR: The FDA guidance on antimicrobial use has not led to substantial reductions in antimicrobial drug resistance yet, and there did not find relevant differences in the presence of AMR genes between pre- and post-VFD drug regulations. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 5, 2023

2023 journal article

Impacts of the <scp>COVID</scp>‐19 pandemic on antimicrobial use in companion animals in an academic veterinary hospital in North Carolina

Zoonoses and Public Health, 70(5), 393–402.

By: A. Jolley n, W. Love n, E. Frey n & C. Lanzas n

author keywords: antimicrobial resistance; antimicrobial use; companion animals; COVID-19; pandemic
TL;DR: The pandemic significantly impacted prescribing practices of antimicrobials for companion animals in an academic veterinary hospital in this study, suggesting that judicious antimicrobial use (AMU) an important strategy for its control. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: May 1, 2023

2023 journal article

Modeling impact of vaccination on COVID-19 dynamics in St. Louis

JOURNAL OF BIOLOGICAL DYNAMICS, 17(1).

By: A. Lacy*, M. Igoe*, P. Das n, T. Farthing n, A. Lloyd n, C. Lanzas n, A. Odoi*, S. Lenhart*

author keywords: Modeling COVID-19 spread; St. Louis area; SafeGraph movement data; vaccination; differential equations
TL;DR: This work investigates how human mobility, vaccination, and time-varying transmission rates influenced SARS-CoV-2 transmission in five counties in the St. Louis area and predicted the changes in disease spread under scenarios with increased vaccination coverage. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 18, 2023

2022 review

A review of epidemiological models of Clostridioides difficile transmission and control (2009e2021)

[Review of ]. ANAEROBE, 74.

By: C. Lanzas n, M. Jara n, R. Tucker n & S. Curtis n

author keywords: Clostridioides difficile; Transmission; Mathematical model; Bibliometric analysis
MeSH headings : Clostridioides; Clostridioides difficile; Clostridium Infections / prevention & control; Cross Infection / epidemiology; Epidemiological Models; Humans
TL;DR: A systematic search and a bibliometric analysis of mathematical and computational models for Clostridioides difficile transmission identified 33 publications from 2009 to 2021 that underscored the importance of asymptomatic colonized patients in maintaining transmission in health-care settings. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 23, 2022

2022 article

Epidemiology of Plasmid Lineages Mediating the Spread of Extended-Spectrum Beta-Lactamases among Clinical Escherichia coli

Mahmud, B., Wallace, M. A., Reske, K. A., Alvarado, K., Muenks, C. E., Rasmussen, D. A., … Dantas, G. (2022, August 22). (C. W. Marshall, Ed.). MSYSTEMS, Vol. 8.

By: B. Mahmud, M. Wallace*, K. Reske*, K. Alvarado*, C. Muenks*, D. Rasmussen n, C. Burnham*, C. Lanzas n, E. Dubberke*, G. Dantas*

Ed(s): C. Marshall

author keywords: Escherichia coli; beta-lactamases; plasmid-mediated resistance
MeSH headings : Humans; Escherichia coli / genetics; Escherichia coli Infections / epidemiology; beta-Lactamases / genetics; Plasmids / genetics; Hospitals
TL;DR: This work provides a detailed picture of plasmid-mediated spread of ESBLs, demonstrating the extensive sequence diversity within identified lineages, while highlighting the genetic elements that underlie the persistence of these plasmids within the clinical E. coli population. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 24, 2022

2022 journal article

Extensions of mean-field approximations for environmentally-transmitted pathogen networks

MATHEMATICAL BIOSCIENCES AND ENGINEERING, 20(2), 1637–1673.

By: K. Davies n, S. Lenhart*, J. Day*, A. Lloyd n & C. Lanzas n

author keywords: environmental transmission; moment closure approximations; mean-field models; network models; individual-based models; infectious disease
MeSH headings : Models, Biological; Environmental Microbiology; Communicable Diseases / transmission
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: December 5, 2022

2022 journal article

Geographic disparities and determinants of COVID-19 incidence risk in the greater St. Louis Area, Missouri (United States)

PLOS ONE, 17(9).

By: P. Das n, M. Igoe*, S. Lenhart*, L. Luong*, C. Lanzas n, A. Lloyd n, A. Odoi*

MeSH headings : COVID-19 / epidemiology; COVID-19 Vaccines; Humans; Incidence; Missouri / epidemiology; Obesity; Socioeconomic Factors; United States
Sources: Web Of Science, NC State University Libraries
Added: April 4, 2023

2022 journal article

Geographic disparities and predictors of COVID-19 hospitalization risks in the St. Louis Area, Missouri (USA)

BMC PUBLIC HEALTH, 22(1).

By: M. Igoe*, P. Das n, S. Lenhart*, A. Lloyd n, L. Luong*, D. Tian*, C. Lanzas n, A. Odoi*

author keywords: Severe Acute Respiratory Syndrome Coronavirus 2; SARS-CoV-2; Coronavirus Disease 2019; COVID-19; Disparities; Hospitalization Risks; Predictors; Negative Binomial Models; Geographically Weighted Regression Models; Epidemiology; Missouri
MeSH headings : COVID-19; Hospitalization; Humans; Missouri / epidemiology; Models, Statistical; SARS-CoV-2
TL;DR: Investigation of Zip Code Tabulation Area (ZCTA)-level geographic disparities and identify predictors of COVID-19 hospitalization risks in the St. Louis area found that a ‘one-size-fits-all’ approach may not be appropriate for management and control. (via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 7, 2022

2022 journal article

Identifying patient-level risk factors associated with non-beta-lactam resistance outcomes in invasive MRSA infections in the United States using chain graphs

JAC-ANTIMICROBIAL RESISTANCE, 4(4).

By: W. Love n, C. Wang n & C. Lanzas n

TL;DR: The differences in resistance phenotypes between patients with previous healthcare use or positive blood cultures, or from different states, may be useful to inform first-choice antibiotics to treat clinical MRSA cases. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 11, 2022

2021 journal article

Assessing the efficacy of interventions to control indoor SARS-Cov-2 transmission: An agent-based modeling approach

EPIDEMICS, 37.

By: T. Farthing n & C. Lanzas n

author keywords: Aerosol; Agent-based model; COVID-19; Droplet; Indoor transmission; SARS-CoV-2
MeSH headings : COVID-19; Humans; SARS-CoV-2; Systems Analysis
TL;DR: It is found that preventing people from moving within the simulated room and efficacious mask usage appear to have the greatest effects on reducing infection risk, but multiple concurrent interventions are required to minimize the proportion of susceptible individuals infected. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 29, 2021

2021 article

Assessing the efficacy of interventions to control indoor SARS-Cov-2 transmission: an agent-based modeling approach

Farthing, T. S., & Lanzas, C. (2021, January 22). (Vol. 1). Vol. 1.

By: T. Farthing n & C. Lanzas n

TL;DR: It is found that imposing movement restrictions and efficacious mask usage appear to have the greatest effects on reducing infection risk, but multiple concurrent interventions are required to minimize the proportion of susceptible individuals infected. (via Semantic Scholar)
Source: ORCID
Added: January 23, 2021

2021 journal article

Combining epidemiological and ecological methods to quantify social effects on Escherichia coli transmission

ROYAL SOCIETY OPEN SCIENCE, 8(10).

By: T. Farthing n, D. Dawson n, M. Sanderson*, H. Seger* & C. Lanzas n

author keywords: contact network; disease ecology; E; coli; network epidemiology; real-time location; social network
TL;DR: Transmission experiments can be combined with real-time location data collection and processing procedures to create an effective framework for quantifying sociobehavioural effects on microparasite transmission, and it is shown that observed effects were not consistent between similar populations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
15. Life on Land (Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 6, 2021

2021 article

Identifying patient-level risk factors associated with non-β-lactam resistance outcomes in invasive methicillin-resistant Staphylococcus aureus infections in the United States using chain graphs

Love, W. J., Wang, C. A., & Lanzas, C. (2021, November 14). (Vol. 11). Vol. 11.

By: W. Love n, C. Wang n & C. Lanzas n

TL;DR: This study analyzed MRSA surveillance data collected by the Centers for Disease Control and Prevention using chain graphs to identify risk factors for individual phenotypic resistance outcomes (reported as minimum inhibitory concentration, MIC) while considering the correlations among themselves. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: November 15, 2021

2021 journal article

Inferring environmental transmission using phylodynamics: a case-study using simulated evolution of an enteric pathogen

JOURNAL OF THE ROYAL SOCIETY INTERFACE, 18(179).

By: D. Dawson n, D. Rasmussen n, X. Peng n & C. Lanzas n

author keywords: environmental transmission; disease transmission modelling; phylodynamics; whole-genome sequencing
MeSH headings : Epidemics; Phylogeny; Probability
TL;DR: It is concluded that prior knowledge of the likely ecology and population structure of pathogens in host and non-host environments is critical to fully using phylodynamic techniques. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 9, 2021

2021 journal article

Mathematically modeling the effect of touch frequency on the environmental transmission of Clostridioides difficile in healthcare settings

MATHEMATICAL BIOSCIENCES, 340.

By: C. Sulyok*, L. Fox*, H. Ritchie n, C. Lanzas n, S. Lenhart* & J. Day*

author keywords: Clostridioides difficile; Environmental transmission; Fomite; Ordinary differential equations; Stochastic simulation; Mathematical model
MeSH headings : Clostridioides difficile; Clostridium Infections / transmission; Cross Infection / transmission; Delivery of Health Care / statistics & numerical data; Environmental Microbiology; Humans; Models, Biological; Touch
TL;DR: Results indicate that on average, under one-quarter of asymptomatically colonized patients are exposed to C. difficile via low-touch fomites, and enhanced efficacy of disinfection upon discharge and extra cleaning of high- touch fomite, reduced contact with high-touch F. difficile, and higher discharge rates, among other control measures, could lead to a decrease in the incidence of colonized individuals. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 4, 2021

2021 article

Modelling the role of mortality-based response triggers on the effectiveness of African swine fever control strategies

Machado, G., Farthing, T. S., Andraud, M., Nunes Lopes, F. P., & Lanzas, C. (2021, October 15). TRANSBOUNDARY AND EMERGING DISEASES, Vol. 10.

By: G. Machado n, T. Farthing n, M. Andraud*, F. Nunes Lopes* & C. Lanzas n

Contributors: G. Machado n, T. Farthing n, M. Andraud*, F. Lopes* & C. Lanzas n

author keywords: network modelling; secure business continuity; surveillance; swine disease dynamics
MeSH headings : African Swine Fever / epidemiology; African Swine Fever / prevention & control; African Swine Fever Virus / physiology; Animals; Disease Outbreaks / veterinary; Epidemics / prevention & control; Epidemics / veterinary; Farms; Swine; Swine Diseases / epidemiology
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 30, 2021

2021 article

When can we stop wearing masks? Agent-based modeling to identify when vaccine coverage makes nonpharmaceutical interventions for reducing SARS-CoV-2 infections redundant in indoor gatherings

Farthing, T. S., & Lanzas, C. (2021, April 27). (Vol. 4). Vol. 4.

By: T. Farthing n & C. Lanzas n

TL;DR: It is found that nonpharmaceutical interventions will often reduce secondary attack rates, especially during brief interactions, and therefore there is no definitive vaccination coverage level that makes nonpharaceutical interventions completely redundant, and the reduction effect on absolute SARS-CoV-2 infection risk conferred by nonphARMaceutical interventions is likely proportional to COVID-19 prevalence. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: April 28, 2021

2020 journal article

Accounting for space and uncertainty in real‐time location system‐derived contact networks

Ecology and Evolution.

By: T. Farthing n, D. Dawson n, M. Sanderson* & C. Lanzas n

author keywords: animal behavior; biotelemetry; contact network; global positioning system; movement ecology; R package; radio telemetry; real-time location
TL;DR: Using the methods described herein and the associated R package, called contact, researchers can derive polygons from RTLS points and it is shown that these polygons are highly versatile for contact network creation and can be used to answer a wide variety of epidemiological, ethological, and sociological research questions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
15. Life on Land (Web of Science)
Source: ORCID
Added: April 13, 2020

2020 journal article

Multi-scale dynamics of infectious diseases

Interface Focus, 10(1), 20190118.

author keywords: mechanistic modelling; ordinary differential equations; foot-and-mouth disease; Listeria; vector-borne disease; infectious disease dynamics
TL;DR: Papers from a workshop to bring together scientists from a variety of disciplines to share expertise gained through looking at infectious diseases across different scales are presented to show the breadth of the field. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: ORCID
Added: December 14, 2019

2020 journal article

On modelling environmentally transmitted pathogens

Interface Focus, 10(1).

By: C. Lanzas n, K. Davies n, S. Erwin n & D. Dawson n

Contributors: C. Lanzas n, K. Davies n, S. Erwin n & D. Dawson n

author keywords: environmental transmission; mean-field models; individual-based models; infectious diseases
TL;DR: A conceptual framework to organize microparasites based on the role that abiotic environments play in their lifecycle is presented, showing considerable divergence between both modelling approaches when conditions do not facilitate well mixing and for pathogens with fast dynamics in the environment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: December 14, 2019

2020 article

Shared Multidrug Resistance Patterns in Chicken-Associated Escherichia coli Identified by Association Rule Mining (vol 10, 687, 2019)

Cazer, C. L., Al-Mamun, M. A., Kaniyamattam, K., Love, W. J., Booth, J. G., Lanzas, C., & Grohn, Y. T. (2020, June 30). FRONTIERS IN MICROBIOLOGY, Vol. 11.

By: C. Cazer*, M. Al-Mamun*, K. Kaniyamattam*, W. Love n, J. Booth*, C. Lanzas n, Y. Grohn*

author keywords: association rule mining; antimicrobial resistance; Escherichia coli; machine learning; multidrug resistance; foodborne bacteria
TL;DR: This research presents a novel probabilistic procedure that allows for direct measurement of the response of the immune system to earthquake-triggered landsliding. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 10, 2020

2019 journal article

Ecological and Socioeconomic Factors Associated with Bartonella henselae Exposure in Dogs Tested for Vector-Borne Diseases in North Carolina

Vector-Borne and Zoonotic Diseases, 19(8), 582–595.

By: E. Lashnits n, D. Dawson n, E. Breitschwerdt n & C. Lanzas n

author keywords: canine; seroreactivity; tick; flea; zoonoses; vector-borne
MeSH headings : Animals; Bartonella Infections / epidemiology; Bartonella Infections / microbiology; Bartonella Infections / veterinary; Bartonella henselae; Dog Diseases / epidemiology; Dog Diseases / microbiology; Dogs; Ecosystem; Female; Male; North Carolina / epidemiology; Retrospective Studies; Risk Factors; Seroepidemiologic Studies; Socioeconomic Factors; Tick-Borne Diseases / epidemiology
TL;DR: Of 25 explanatory factors considered, the model combining demographic, socioeconomic, climatic, and land use variables fits best, and female intact sex and increasing percentage of the county with low-intensity development and evergreen forest were associated with higher seroreactivity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 4, 2019

2019 journal article

Estimation of multidrug resistance variability in the National Antimicrobial Monitoring System

PREVENTIVE VETERINARY MEDICINE, 167, 137–145.

By: K. Zawack*, W. Love n, C. Lanzas n, J. Booth* & Y. Grohn*

author keywords: Antimicrobial resistance; Multidrug resistance; Variability; Monitoring
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Chickens; Drug Resistance, Multiple, Bacterial; Escherichia coli / drug effects; Food Microbiology; Meat / microbiology; Microbial Sensitivity Tests; United States
TL;DR: The level of variability in the NARMS dataset makes it difficult to detect multidrug resistance patterns at the current level of sample collection, and large scale monitoring programs should collect more variables on each of the samples. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 28, 2019

2019 journal article

Metapopulation Model from Pathogen's Perspective: A Versatile Framework to Quantify Pathogen Transfer and Circulation between Environment and Hosts

SCIENTIFIC REPORTS, 9.

By: S. Chen*, C. Lanzas n, C. Lee*, G. Zenarosa*, A. Arif* & M. Dulin*

MeSH headings : Algorithms; Cross Infection / prevention & control; Cross Infection / transmission; Disinfection; Host-Pathogen Interactions; Humans; Models, Biological; Population Dynamics
TL;DR: It is demonstrated that metapopulation models serve as an ideal modeling framework to characterize and quantify pathogen transfer between environment and hosts and unifies host, pathogen, and environment, collectively known as the epidemiological triad, a fundamental concept in epidemiology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 25, 2019

2019 journal article

Shared Multidrug Resistance Patterns in Chicken-Associated Escherichia coli Identified by Association Rule Mining

FRONTIERS IN MICROBIOLOGY, 10.

By: C. Cazer*, M. Al-Mamun*, K. Kaniyamattam*, W. Love n, J. Booth*, C. Lanzas n, Y. Grohn*

author keywords: association rule mining; antimicrobial resistance; Escherichia coli; machine learning; multidrug resistance; foodborne bacteria
TL;DR: A strong subnetwork of beta-lactam resistance existed in each year and the beta- lactam resistances also had strong associations with sulfisoxazole, gentamicin, streptomycin and tetracycline resistances. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 29, 2019

2019 journal article

Transmission on empirical dynamic contact networks is influenced by data processing decisions

EPIDEMICS, 26, 32–42.

By: D. Dawson n, T. Farthing n, M. Sanderson* & C. Lanzas n

author keywords: Dynamic contact data; Data processing; Entropy; Contact networks; Transmission dynamics; Disease transmission model
MeSH headings : Animals; Cattle; Cattle Diseases / epidemiology; Cattle Diseases / transmission; Epidemics / statistics & numerical data; Epidemics / veterinary; Models, Statistical
TL;DR: It is found that changes made to information content by processing decisions translated to significant impacts to the transmission dynamics of disease models using the contact data, and that SpTh had the largest independent influence on information content. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 15, 2019

2018 journal article

Inferring the interaction structure of resistance to antimicrobials

PREVENTIVE VETERINARY MEDICINE, 152, 81–88.

By: K. Zawack*, W. Love n, C. Lanzas n, J. Booth* & Y. Grohn*

author keywords: Interactions; Log-linear models; Bayesian statistics; Multidrug resistance
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Bayes Theorem; Chickens; Drug Resistance, Bacterial; Escherichia coli / drug effects; Food Microbiology; Linear Models; Meat / microbiology; Turkeys
TL;DR: A Bayesian approach is adopted which reveals that E. coli resistance associations can be broken into two subnetworks, characterized by more complex interactions between a variety of drug classes that vary between the chicken and turkey datasets. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2018 journal article

Investigating behavioral drivers of seasonal Shiga-Toxigenic Escherichia Coli (STEC) patterns in grazing cattle using an agent-based model

PLOS ONE, 13(10).

By: D. Dawson n, J. Keung*, M. Napoles*, M. Vella*, S. Chen n, M. Sanderson*, C. Lanzas n

MeSH headings : Animals; Cattle; Cattle Diseases / microbiology; Cattle Diseases / transmission; Drinking Behavior / physiology; Escherichia coli Infections / microbiology; Escherichia coli Infections / transmission; Escherichia coli Infections / veterinary; Escherichia coli O157 / pathogenicity; Feces / microbiology; Herbivory / physiology; Seasons; Weather
TL;DR: A spatially explicit agent-based model was constructed that accounted for the effect of temperature fluctuations on cattle behavior and its effect on pathogen survival in the environment, and model simulations indicated that factors influencing cattle aggregation, such as temperature, were likely strong drivers of transmission dynamics of enteric pathogens. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 29, 2018

2018 journal article

Pathogen transfer through environment-host contact: an agent-based queueing theoretic framework

MATHEMATICAL MEDICINE AND BIOLOGY-A JOURNAL OF THE IMA, 35(3), 409–425.

By: S. Chen n, S. Lenhart n, J. Day*, C. Lee*, M. Dulin* & C. Lanzas n

author keywords: queueing theory; pathogen transfer and decay; environment-host contact; agent-based model; health care contact process; model framework
MeSH headings : Computer Simulation; Cross Infection / transmission; Disease Transmission, Infectious; Environmental Exposure; Host-Pathogen Interactions / physiology; Humans; Mathematical Concepts; Models, Biological; Nonlinear Dynamics; Stochastic Processes; Systems Theory
TL;DR: A flexible and customizable queueing theory modelling framework with three major subroutines to study the in-hospital contact processes between environments and hosts and potential nosocomial pathogen transfer, where environments are servers and hosts are customers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 10, 2018

2018 journal article

Phenotypical resistance correlation networks for 10 non-typhoidal Salmonella subpopulations in an active antimicrobial surveillance programme.

Epidemiology and Infection.

Cristina Lanzas

author keywords: Antibiotic resistance; epidemiology; statistics; veterinary epidemiology; veterinary pathogens
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Azithromycin / pharmacology; Ceftriaxone / pharmacology; Ciprofloxacin / pharmacology; Drug Resistance, Bacterial; Linear Models; Meat / microbiology; Phenotype; Salmonella Infections, Animal / drug therapy; Salmonella enterica / drug effects; Salmonella enterica / genetics; Selection, Genetic; United States
TL;DR: Several important resistances in iNTS serotypes are identified and further research is needed to identify the causative genetic correlations, and direct selection for ciprofloxacin resistance via collateral selection appears unlikely. (via Semantic Scholar)
Source: ORCID
Added: September 9, 2019

2018 journal article

Shifts in the Gut Metabolome and Clostridium difficile Transcriptome throughout Colonization and Infection in a Mouse Model

MSPHERE, 3(2).

By: J. Fletcher n, S. Erwin n, C. Lanzas n & C. Theriot n

Contributors: J. Fletcher n, S. Erwin n, C. Lanzas n & C. Theriot n

author keywords: Clostridium difficile; amino acids; intestinal colonization; metabolomics; peptides; transcriptomics
MeSH headings : Amino Acids, Branched-Chain / metabolism; Animals; Anti-Bacterial Agents / administration & dosage; Carbohydrate Metabolism; Cecum / microbiology; Clostridioides difficile / metabolism; Clostridium Infections / metabolism; Clostridium Infections / microbiology; Female; Gastrointestinal Microbiome; Gene Expression Profiling; Male; Mass Spectrometry; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; Peptide Hydrolases / genetics; Proline / metabolism; Sequence Analysis, RNA; Transcriptome
TL;DR: The gut environment after antibiotics and during the initial stages of C. difficile colonization and infection is defined and amino acids, in particular, proline and branched-chain amino acids and carbohydrates decrease in abundance over time and that C.difficile gene expression is consistent with their utilization in vivo. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 review

A proposed analytic framework for determining the impact of an antimicrobial resistance intervention

[Review of ]. ANIMAL HEALTH RESEARCH REVIEWS, 18(1), 1–25.

By: Y. Grohn*, C. Carson*, C. Lanzas n, L. Pullum*, M. Stanhope* & V. Volkova*

author keywords: antimicrobial use; antimicrobial resistance; intervention strategy; analytic framework
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Drug Resistance, Bacterial; Drug Utilization / legislation & jurisprudence; United States; United States Food and Drug Administration
TL;DR: A system framework to address the methodological gap linking livestock AMU and AMR in foodborne bacteria is proposed, and two methods to model phenotypic AMR changes in bacteria in the food supply and evolutionary genotypic analyses determining molecular changes in phenotypIC AMR are studied. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

Antimicrobial Stewardship and Environmental Decontamination for the Control of Clostridium difficile Transmission in Healthcare Settings

BULLETIN OF MATHEMATICAL BIOLOGY, 79(1), 36–62.

By: J. Bintz*, S. Lenhart* & C. Lanzas n

author keywords: Clostridium difficile; Control; Agent-based model
MeSH headings : Anti-Bacterial Agents / adverse effects; Clostridioides difficile / pathogenicity; Computer Simulation; Cross Infection / prevention & control; Cross Infection / transmission; Decontamination / methods; Enterocolitis, Pseudomembranous / prevention & control; Enterocolitis, Pseudomembranous / transmission; Environmental Microbiology; Gastrointestinal Microbiome / drug effects; Humans; Mathematical Concepts; Models, Biological
TL;DR: An agent-based model for Clostridium difficile transmission in hospitals is implemented that accounts for several processes and individual factors including environmental and antibiotic heterogeneity in order to evaluate the efficacy of various control measures aimed at reducing environmental contamination and mitigating the effects of antibiotic use on transmission. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Arresting Contagion: Science, Policy, and Conflicts Over Animal Disease Control. By Alan L. Olmstead and Paul W. Rhode. Cambridge (Massachusetts): Harvard University Press. $49.95. xi + 465 p.; ill.; index. ISBN: 978-0-674-72877-6. 2015.

The Quarterly Review of Biology, 92(4), 456–457.

By: C. Lanzas n

Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2017 journal article

Epigenetics, obesity and early-life cadmium or lead exposure

EPIGENOMICS, 9(1), 57–75.

author keywords: cadmium; DNA methylation; epigenetics; lead; obesity
MeSH headings : Animals; Cadmium Poisoning / epidemiology; Cadmium Poisoning / genetics; DNA Methylation; Epigenesis, Genetic; Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / genetics; Humans; Lead Poisoning / epidemiology; Lead Poisoning / genetics; Obesity / epidemiology; Obesity / genetics; Obesity / microbiology
TL;DR: The keys to understanding how metal exposure contributes to obesity are improved assessment of exposure and comprehensive establishment of epigenetic profiles that may serve as markers for exposures. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 chapter

Mathematical Modeling of the Effects of Nutrient Competition and Bile Acid Metabolism by the Gut Microbiota on Colonization Resistance Against Clostridium difficile

In Association for Women in Mathematics Series (pp. 137–161).

By: A. Fleming-Davies*, S. Jabbari*, S. Robertson*, T. Asih*, C. Lanzas n, S. Lenhart*, C. Theriot n

Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2017 journal article

Optimal control of vaccination rate in an epidemiological model of Clostridium difficile transmission

JOURNAL OF MATHEMATICAL BIOLOGY, 75(6-7), 1693–1713.

By: B. Stephenson*, C. Lanzas n, S. Lenhart* & J. Day*

author keywords: Optimal control; Clostridium difficile; Vaccination; Ordinary differential equations; Healthcare setting
MeSH headings : Bacterial Vaccines / pharmacology; Clostridioides difficile; Computer Simulation; Cross Infection / epidemiology; Cross Infection / prevention & control; Cross Infection / transmission; Disease Susceptibility; Enterocolitis, Pseudomembranous / epidemiology; Enterocolitis, Pseudomembranous / prevention & control; Enterocolitis, Pseudomembranous / transmission; Epidemics / prevention & control; Epidemics / statistics & numerical data; Humans; Mathematical Concepts; Models, Biological; Time Factors; Vaccination / methods; Vaccination / statistics & numerical data
TL;DR: This paper modify and update a compartmental model of nosocomial C. difficile transmission to include vaccination and applies optimal control theory to determine the time-varying optimal vaccination rate that minimizes a combination of disease prevalence and spread in the hospital population as well as cost, in terms of time and money, associated with vaccination. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

An Evaluation of Food as a Potential Source for Clostridium difficile Acquisition in Hospitalized Patients

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 37(12), 1401–1407.

By: J. Kwon*, C. Lanzas n, K. Reske*, T. Hink*, S. Seiler*, K. Bommarito*, C. Burnham*, E. Dubberke*

MeSH headings : Academic Medical Centers; Adult; Aged; Aged, 80 and over; Clostridioides difficile / isolation & purification; Cross Infection / microbiology; Enterocolitis, Pseudomembranous; Feces / microbiology; Female; Food Microbiology; Hospitalization; Humans; Inpatients; Male; Middle Aged; Missouri; Prospective Studies; Young Adult
TL;DR: Stochastic modeling indicated contaminated hospital food would be responsible for less than 1 newly colonized patient per 1,000 hospital admissions, and modeling suggests hospital food is unlikely to be a source of C. difficile acquisition. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Basic Reproduction Number and Transmission Dynamics of Common Serogroups of Enterohemorrhagic Escherichia coli

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 82(18), 5612–5620.

By: S. Chen n, M. Sanderson*, C. Lee*, N. Cernicchiaro*, D. Renter* & C. Lanzas n

MeSH headings : Adhesins, Bacterial / genetics; Animals; Basic Reproduction Number; Cattle; Cross-Sectional Studies; Disease Transmission, Infectious; Enterohemorrhagic Escherichia coli / classification; Enterohemorrhagic Escherichia coli / isolation & purification; Environmental Exposure; Escherichia coli Infections / epidemiology; Escherichia coli Infections / microbiology; Escherichia coli Infections / transmission; Escherichia coli Infections / veterinary; Escherichia coli Proteins / genetics; O Antigens / analysis; Prevalence; Serogroup; Shiga Toxins / genetics; United States / epidemiology
TL;DR: A Bayesian modeling framework is described to estimate basic reproduction numbers of multiple serotypes of Shiga toxin-producing Escherichia coli according to a cross-sectional study and can be readily expanded to other pathogen systems in order to estimate the pathogen and external factors that influence spread of infectious agents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Distinction and connection between contact network, social network, and disease transmission network

PREVENTIVE VETERINARY MEDICINE, 131, 8–11.

By: S. Chen n & C. Lanzas n

Contributors: S. Chen n & C. Lanzas n

author keywords: Animal contact network; Social network; Disease transmission network; Distinction; Connection
MeSH headings : Animal Husbandry; Animals; Cattle; Cattle Diseases / transmission
TL;DR: A modeling framework is established to track potential disease transmission dynamics and construct transmission network based on the observed animal contact network and demonstrate that social and disease transmission networks can be derived as spanning subgraphs of contact network. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Markov Networks of Collateral Resistance: National Antimicrobial Resistance Monitoring System Surveillance Results from Escherichia coli Isolates, 2004-2012

PLOS COMPUTATIONAL BIOLOGY, 12(11).

By: W. Love n, K. Zawack*, J. Booth*, Y. Grohn* & C. Lanzas n

Ed(s): M. Tanaka

MeSH headings : Anti-Bacterial Agents / therapeutic use; Bacterial Infections / epidemiology; Bacterial Infections / microbiology; Computer Simulation; Drug Resistance, Bacterial; Escherichia coli / drug effects; Escherichia coli / isolation & purification; Humans; Markov Chains; Models, Statistical; Population Surveillance / methods; Prevalence; Reproducibility of Results; Risk Assessment / methods; Sensitivity and Specificity; Treatment Outcome
TL;DR: The current method provides a novel method to study the joint resistance distribution, but additional work is required to unite the underlying biological and genetic characteristics of the isolates with the current results derived from phenotypic data. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Mathematical modeling tools to study preharvest food safety

Microbiology Spectrum, 4(4).

By: C. Lanzas & S. Chen

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Monitoring Antimicrobial Resistance in the Food Supply Chain and Its Implications for FDA Policy Initiatives

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 60(9), 5302–5311.

By: K. Zawack*, M. Li*, J. Booth*, W. Love n, C. Lanzas n & Y. Grohm

MeSH headings : Abattoirs / legislation & jurisprudence; Analysis of Variance; Animals; Anti-Bacterial Agents / pharmacology; Campylobacter coli / drug effects; Campylobacter coli / growth & development; Campylobacter jejuni / drug effects; Campylobacter jejuni / growth & development; Cattle; Ciprofloxacin / pharmacology; Drug Resistance, Multiple, Bacterial; Enrofloxacin; Escherichia coli / drug effects; Escherichia coli / growth & development; Fluoroquinolones / pharmacology; Food Handling / legislation & jurisprudence; Food Microbiology; Food Supply / legislation & jurisprudence; Humans; Meat / microbiology; Microbial Sensitivity Tests; Poultry / microbiology; Salmonella typhimurium / drug effects; Salmonella typhimurium / growth & development; Swine; United States; United States Food and Drug Administration / legislation & jurisprudence
TL;DR: Detailed analysis of data provided by the National Antimicrobial Resistance Monitoring System showed the complexities of the AMR policy with no statistically significant change in resistance of both Campylobacter jejuni and Campyloblacter coli to ciprofloxacin, another second-generation fluoroquinolone. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Complex system modelling for veterinary epidemiology

Preventive Veterinary Medicine, 118(2-3), 207–214.

By: C. Lanzas* & S. Chen*

Contributors: C. Lanzas* & S. Chen*

author keywords: Mathematical modelling; Veterinary epidemiology; Complex systems; Agent-based model; Network
MeSH headings : Animals; Biometry / methods; Communicable Diseases / epidemiology; Communicable Diseases / transmission; Communicable Diseases / veterinary; Contact Tracing / methods; Contact Tracing / veterinary; Disease Outbreaks / veterinary; Epidemiologic Methods / veterinary; Models, Biological; Models, Theoretical; Veterinary Medicine
TL;DR: The principles, advantages, and challenges associated with the most recent modelling approaches used in systems science, the interdisciplinary study of complex systems, including agent-based, network and compartmental modelling are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: September 9, 2019

2015 journal article

Spatial-Temporal Dynamics of High-Resolution Animal Networks: What Can We Learn from Domestic Animals?

PLOS ONE, 10(6).

By: S. Chen n, A. Ilany*, B. White*, M. Sanderson* & C. Lanzas n

Contributors: S. Chen n, A. Ilany*, B. White*, M. Sanderson* & C. Lanzas n

MeSH headings : Algorithms; Animals; Animals, Domestic; Behavior, Animal; Cattle; Cluster Analysis; Communicable Diseases / transmission; Environment; Social Behavior; Spatio-Temporal Analysis
TL;DR: Real-time location system is used to accurately track cattle position, analyze their proximity networks, and tested the hypothesis of temporal stationarity and spatial homogeneity in these networks during different daily time periods and in different areas of the pen. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Accurate prediction of major histocompatibility complex class II epitopes by sparse representation via ℓ 1-minimization

BioData Mining.

By: C. Aguilar-Bonavides*, R. Sanchez-Arias* & C. Lanzas*

Contributors: C. Aguilar-Bonavides*, R. Sanchez-Arias* & C. Lanzas*

author keywords: Peptide binding; Sparse representation; MHC class II; Epitope prediction; Immunoinformatics; Machine learning; Classification algorithms
Source: ORCID
Added: September 9, 2019

2014 journal article

Effectiveness of screening hospital admissions to detect asymptomatic carriers of Clostridium difficile: A modeling evaluation

Infection Control and Hospital Epidemiology, 35(8), 1043–1050.

By: C. Lanzas* & E. Dubberke*

Contributors: C. Lanzas* & E. Dubberke*

MeSH headings : Asymptomatic Infections / epidemiology; Clostridioides difficile; Clostridium Infections / diagnosis; Clostridium Infections / microbiology; Clostridium Infections / prevention & control; Cross Infection / epidemiology; Cross Infection / microbiology; Cross Infection / prevention & control; Female; Humans; Male; Middle Aged; Models, Theoretical; Patient Admission / statistics & numerical data; Prevalence
TL;DR: Testing for asymptomatic carriers at admission may reduce both the number of new colonizations and HO-CDI cases, and additional reductions could be achieved by preventing disease in patients who are admitted as asymPTomatic carriers and developed CDI during the hospital stay. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: September 9, 2019

2014 journal article

Highly dynamic animal contact network and implications on disease transmission

Scientific Reports, 4.

By: S. Chen*, B. White*, M. Sanderson*, D. Amrine*, A. Ilany* & C. Lanzas*

Contributors: S. Chen*, B. White*, M. Sanderson*, D. Amrine*, A. Ilany* & C. Lanzas*

MeSH headings : Animals; Communicable Diseases / genetics; Communicable Diseases / pathology; Communicable Diseases / transmission; Computer Simulation; Disease Outbreaks; Host-Parasite Interactions / genetics; Models, Biological; Models, Theoretical
TL;DR: This study used high temporal and spatial resolution animal position data to construct a high-resolution contact network relevant to infectious disease transmission and indicated that disease dynamics and individual contribution to new infections varied substantially among these four conditions under both parameter settings. (via Semantic Scholar)
Source: ORCID
Added: September 9, 2019

2013 journal article

Evaluating targets for control of plasmid-mediated antimicrobial resistance in enteric commensals of beef cattle: A modelling approach

Epidemiology and Infection, 141(11), 2294–2312.

By: V. Volkova*, Z. Lu*, C. Lanzas* & Y. Grohn*

Contributors: V. Volkova*, Z. Lu*, C. Lanzas* & Y. Grohn*

author keywords: Antimicrobial resistance; cattle; ceftiofur; cephalosporin; enteric commensal bacteria; Escherichia coli
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Cattle; Computer Simulation; Drug Resistance, Bacterial; Escherichia coli / drug effects; Escherichia coli / genetics; Escherichia coli / physiology; Gene Expression Regulation, Bacterial; Intestines / microbiology; Male; Models, Biological; Plasmids / genetics
TL;DR: A deterministic mathematical model of commensal Escherichia coli in its animate and non-animate habitats within a beef feedlot's pen is developed, with some E. coli having plasmid-mediated resistance to the cephalosporin ceftiofur. (via Semantic Scholar)
Source: ORCID
Added: September 9, 2019

2013 journal article

Evalution of the "Iceberg Phenomenon" in Johne's Disease through Mathematical Modelling

PLoS ONE, 8(10).

By: G. Magombedze*, C. Ngonghala* & C. Lanzas*

Contributors: G. Magombedze*, C. Ngonghala* & C. Lanzas*

MeSH headings : Animals; Cattle; Cattle Diseases / microbiology; Cattle Diseases / physiopathology; Models, Biological; Mycobacterium avium subsp. paratuberculosis; Paratuberculosis / microbiology; Paratuberculosis / physiopathology
TL;DR: A deterministic ordinary differential equation model of JD transmission and disease progression dynamics is developed and duration periods associated with the natural course of the disease progression are used, and the above ratios do not hold. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: September 9, 2019

2013 journal article

Investigating effects of between- and within-host variability on Escherichia coli O157 shedding pattern and transmission

Preventive Veterinary Medicine, 109(1-2), 47–57.

By: S. Chen*, M. Sanderson* & C. Lanzas*

Contributors: S. Chen*, M. Sanderson* & C. Lanzas*

author keywords: Escherichia coli 0157; Fecal shedding; Between- and within-host variability; Supershedder; Mathematical model
MeSH headings : Animals; Bacterial Shedding; Cattle; Cattle Diseases / epidemiology; Cattle Diseases / microbiology; Cattle Diseases / transmission; Escherichia coli Infections / epidemiology; Escherichia coli Infections / microbiology; Escherichia coli Infections / transmission; Escherichia coli Infections / veterinary; Escherichia coli O157 / physiology; Feces / microbiology; Humans; Models, Biological; Prevalence
TL;DR: It is demonstrated that even without between-host variability, the prevalence of animals with concentration of E. coli O157 in feces that exceeds 10(4)CFU/g is similar to that observed in cross-sectional field data. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: September 9, 2019

2013 journal article

Modelling dynamics of plasmid-gene mediated antimicrobial resistance in enteric bacteria using stochastic differential equations

Scientific Reports, 3.

Contributors: V. Volkova*, Z. Lu*, C. Lanzas*, H. Scott* & Y. Gröhn*

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Cattle; Computer Simulation; Drug Resistance, Bacterial / genetics; Enterobacteriaceae / drug effects; Enterobacteriaceae / genetics; Enterobacteriaceae Infections / epidemiology; Enterobacteriaceae Infections / genetics; Enterobacteriaceae Infections / veterinary; Models, Genetic; Models, Statistical; Plasmids / genetics; Prevalence
TL;DR: The results demonstrated that demographic stochasticity among enteric E. coli in the occurrence of relevant events was important for the AMR dynamics only when bacterial numbers were depressed during therapy. (via Semantic Scholar)
Source: ORCID
Added: September 9, 2019

2013 journal article

Temporal-spatial heterogeneity in animal-environment contact: Implications for the exposure and transmission of pathogens

Scientific Reports, 3.

By: S. Chen*, M. Sanderson, B. White*, D. Amrine & C. Lanzas*

Contributors: S. Chen*, M. Sanderson, B. White*, D. Amrine & C. Lanzas*

MeSH headings : Animals; Cattle; Communicable Diseases / epidemiology; Communicable Diseases / transmission; Computer Simulation; Environment; Environmental Exposure; Humans; Models, Theoretical; Prevalence; Sentinel Surveillance; Spatio-Temporal Analysis
TL;DR: Heterogeneity in environmental contact structure among cattle influences pathogen prevalence and exposure associated with each environment, and interventions that target environmental areas, even relatively small areas, with high bacterial concentration can result in effective mitigation of environmentally transmitted pathogens. (via Semantic Scholar)
Source: ORCID
Added: September 9, 2019

2012 journal article

Mathematical model of plasmid-mediated resistance to ceftiofur in commensal enteric escherichia coli of cattle

PLoS ONE, 7(5).

By: V. Volkova*, C. Lanzas*, Z. Lu* & Y. Gröhn*

Contributors: V. Volkova*, C. Lanzas*, Z. Lu* & Y. Gröhn*

MeSH headings : Animals; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / pharmacology; Cattle; Cephalosporins / pharmacokinetics; Cephalosporins / pharmacology; Escherichia coli / drug effects; Intestines / microbiology; Microbial Sensitivity Tests; Plasmids
TL;DR: A deterministic mathematical model of the dynamics of ceftiofur-sensitive and resistant commensal enteric Escherichia coli in enteric commensals of cattle indicated that a low but stable fraction of resistant enteric E. coli could persist in the absence of immediate ceftofur pressure, being sustained by horizontal and vertical transfers of plasmids carrying resistance-genes. (via Semantic Scholar)
Source: ORCID
Added: September 9, 2019

2011 journal article

Epidemiological model for Clostridium difficile transmission in healthcare settings

Infection Control and Hospital Epidemiology, 32(6), 553–561.

Contributors: C. Lanzas*, E. Dubberke*, Z. Lu*, K. Reske* & Y. Gröhn*

MeSH headings : Carrier State / epidemiology; Clostridioides difficile; Clostridium Infections / epidemiology; Clostridium Infections / transmission; Cross Infection / epidemiology; Cross Infection / transmission; Epidemiologic Methods; Hospitals; Humans; Models, Statistical; Retrospective Studies
TL;DR: It is suggested that transmission within the ward alone from patients with CDI cannot sustain new C. difficile colonizations and therefore that the admission of colonized patients plays an important role in sustaining transmission in the ward. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: September 9, 2019

2011 journal article

Mathematical modeling of the transmission and control of foodborne pathogens and antimicrobial resistance at preharvest

Foodborne Pathogens and Disease, 8(1), 1–10.

By: C. Lanzas*, Z. Lu* & Y. Gröhn*

Contributors: C. Lanzas*, Z. Lu* & Y. Gröhn*

MeSH headings : Agriculture; Animals; Disease Transmission, Infectious / statistics & numerical data; Disease Transmission, Infectious / veterinary; Drug Resistance, Microbial; Food Microbiology / statistics & numerical data; Foodborne Diseases / epidemiology; Foodborne Diseases / veterinary; Humans; Livestock / microbiology; Models, Biological; Models, Theoretical; Stochastic Processes; Zoonoses / epidemiology
TL;DR: This review aims to present the principles underlying the mathematical modeling of foodborne pathogens and antimicrobial resistance at the farm level to a broader audience. (via Semantic Scholar)
Source: ORCID
Added: September 9, 2019

2011 journal article

The ecology and pathobiology of Clostridium difficile infections: An interdisciplinary challenge

Zoonoses and Public Health, 58(1), 4–20.

Contributors: E. Dubberke*, D. Haslam*, C. Lanzas*, L. Bobo*, C. Burnham*, Y. Gröhn*, P. Tarr*

author keywords: Clostridium difficile; infection; human; veterinary
MeSH headings : Animals; Clostridioides difficile / pathogenicity; Communicable Diseases, Emerging / epidemiology; Communicable Diseases, Emerging / prevention & control; Communicable Diseases, Emerging / transmission; Communicable Diseases, Emerging / veterinary; Enterocolitis, Pseudomembranous / epidemiology; Enterocolitis, Pseudomembranous / prevention & control; Enterocolitis, Pseudomembranous / transmission; Enterocolitis, Pseudomembranous / veterinary; Food Contamination; Food Microbiology; Humans; Incidence; Infection Control / methods; Risk Factors; Virulence; Zoonoses
TL;DR: The purposes of this review are to highlight the many challenges to diagnosing, treating, and preventing C. difficile infection in humans, and to stress that collaboration between human and veterinary researchers is needed to control this pathogen. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: September 9, 2019

2010 journal article

Model or meal? Farm animal populations as models for infectious diseases of humans

Nature Reviews Microbiology, 8(2), 139–148.

By: C. Lanzas*, P. Ayscue*, R. Ivanek* & Y. Gröhn*

Contributors: C. Lanzas*, P. Ayscue*, R. Ivanek* & Y. Gröhn*

MeSH headings : Animals; Animals, Domestic / microbiology; Animals, Domestic / virology; Communicable Diseases / microbiology; Communicable Diseases / transmission; Communicable Diseases / virology; Disease Models, Animal; Host-Pathogen Interactions; Humans; Models, Biological; Population
TL;DR: Farm animal populations can provide empirical models to study infectious diseases at the population level because they have been widely used as models at the organism level and are less appropriate for addressing issues at thepopulation level. (via Semantic Scholar)
Source: ORCID
Added: September 9, 2019

2010 journal article

Transmission dynamics of a multidrug-resistant salmonella typhimurium outbreak in a dairy farm

Foodborne Pathogens and Disease, 7(4), 467–474.

By: C. Lanzas*, L. Warnick*, K. James*, E. Wright*, M. Wiedmann* & Y. Gröhn*

Contributors: C. Lanzas*, L. Warnick*, K. James*, E. Wright*, M. Wiedmann* & Y. Gröhn*

MeSH headings : Animals; Anti-Infective Agents / pharmacology; Bacterial Shedding; Cattle; Cattle Diseases / epidemiology; Cattle Diseases / microbiology; Cattle Diseases / transmission; Computer Simulation; Dairying / methods; Disease Outbreaks / veterinary; Drug Resistance, Multiple, Bacterial; Electrophoresis, Gel, Pulsed-Field / veterinary; Feces / microbiology; Longitudinal Studies; Microbial Sensitivity Tests / veterinary; Models, Statistical; Salmonella Infections, Animal / epidemiology; Salmonella Infections, Animal / microbiology; Salmonella Infections, Animal / transmission; Salmonella typhimurium / classification; Salmonella typhimurium / drug effects; Salmonella typhimurium / isolation & purification; Salmonella typhimurium / pathogenicity; Serologic Tests / veterinary; Serotyping / veterinary; Time Factors
TL;DR: Simulations of the transmission model indicated that salmonellosis outbreaks with few clinical cases were likely due to the extinction of the pathogen in the premises in the early phase of the outbreaks, and small population size and group structure within the farm decrease the on-farm persistence of the Pathogen. (via Semantic Scholar)
Source: ORCID
Added: September 9, 2019

2009 journal article

Development of a mechanistic model to represent the dynamics of particle flow out of the rumen and to predict rate of passage of forage particles in dairy cattle

Journal of Dairy Science, 92(8), 3981–4000.

By: S. Seo*, C. Lanzas*, L. Tedeschi*, A. Pell* & D. Fox*

Contributors: S. Seo*, C. Lanzas*, L. Tedeschi*, A. Pell* & D. Fox*

author keywords: rumen passage rate; ruminal particle dynamics; modeling
MeSH headings : Animal Feed / analysis; Animals; Cattle / metabolism; Computer Simulation; Dairying; Female; Models, Biological; Rumen / metabolism
TL;DR: A mechanistic and dynamic model was developed to represent physiological aspects of particle dynamics in the reticulo-rumen (RR) and to predict rate of passage out of the RR (Kp) of forage particles quantitatively and it is concluded that this model can be used to understand the factors that affect the dynamics of particle flow out ofthe RR and predict Kp of particles out ofThe RR in dairy cattle. (via Semantic Scholar)
Source: ORCID
Added: September 9, 2019

2009 journal article

Modeling on-farm Escherichia coli O157:H7 population dynamics

Foodborne Pathogens and Disease, 6(4), 461–470.

By: P. Ayscue*, C. Lanzas*, R. Ivanek* & Y. Gröhn*

Contributors: P. Ayscue*, C. Lanzas*, R. Ivanek* & Y. Gröhn*

MeSH headings : Animal Husbandry / standards; Animals; Cattle; Cattle Diseases / prevention & control; Cattle Diseases / transmission; Colony Count, Microbial / methods; Colony Count, Microbial / veterinary; Disease Reservoirs / microbiology; Disease Reservoirs / veterinary; Environmental Microbiology; Escherichia coli Infections / prevention & control; Escherichia coli Infections / transmission; Escherichia coli Infections / veterinary; Escherichia coli O157 / growth & development; Escherichia coli O157 / isolation & purification; Humans; Kinetics; Mathematics; Models, Biological; Population Dynamics; Water Microbiology; Zoonoses
Source: ORCID
Added: September 9, 2019

2008 journal article

Improved feed protein fractionation schemes for formulating rations with the cornell net carbohydrate and protein system

Journal of Dairy Science, 91(12), 4881–4891.

By: C. Lanzas*, G. Broderick* & D. Fox*

Contributors: C. Lanzas*, G. Broderick* & D. Fox*

author keywords: feed protein fractionation; protein supply; nutritional model
MeSH headings : Animal Feed; Dietary Carbohydrates / analysis; Dietary Proteins / analysis; Dietary Proteins / metabolism; Food Technology / methods; Food Technology / standards
TL;DR: Evaluating the original Cornell Net Carbohydrate Protein System (CNCPS) protein fractionation scheme and developing and evaluating alternatives designed to improve its adequacy in predicting RDP and RUP concluded that implementing alternative 1 or 2 will improve the accuracy of predicting R DP and Rup within the CNCPS framework. (via Semantic Scholar)
Source: ORCID
Added: September 9, 2019

2008 journal article

The effect of heterogeneous infectious period and contagiousness on the dynamics of Salmonella transmission in dairy cattle

Epidemiology and Infection, 136(11), 1496–1510.

Contributors: C. Lanzas*, S. Brien*, R. Ivanek*, Y. Lo*, P. Chapagain*, K. Ray*, P. Ayscue*, L. Warnick*, Y. Gröhn*

MeSH headings : Animals; Basic Reproduction Number; Cattle; Cattle Diseases / epidemiology; Cattle Diseases / microbiology; Cattle Diseases / transmission; Computer Simulation; Infection Control / methods; Models, Statistical; Prevalence; Salmonella Infections, Animal / epidemiology; Salmonella Infections, Animal / transmission; Time Factors
TL;DR: The presence of super-shedders increases R0 and decreases the effectiveness of population-wise strategies to reduce infection, making necessary the application of strategies that target this specific group. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: September 9, 2019

2008 journal article

The risk and control of Salmonella outbreaks in calf-raising operations: A mathematical modeling approach

Veterinary Research, 39(6).

Contributors: C. Lanzas*, L. Warnick*, R. Ivanek*, P. Ayscue*, D. Nydam* & Y. Gröhn*

MeSH headings : Animal Husbandry; Animals; Cattle; Disease Outbreaks / veterinary; Models, Biological; Prevalence; Risk Factors; Salmonella Infections, Animal / epidemiology; Salmonella Infections, Animal / prevention & control
TL;DR: The most effective strategies to control ongoing outbreaks were to completely close the rearing operation to incoming calves, to increase the proportion of admitted calves that were immunized (>75%), and to assign personnel and equipment to groups of calves. (via Semantic Scholar)
Source: ORCID
Added: September 9, 2019

2007 journal article

A revised CNCPS feed carbohydrate fractionation scheme for formulating rations for ruminants

Animal Feed Science and Technology, 136(3-4), 167–190.

By: C. Lanzas*, C. Sniffen, S. Seo*, L. Tedeschi* & D. Fox*

Contributors: C. Lanzas*, C. Sniffen, S. Seo*, L. Tedeschi* & D. Fox*

author keywords: carbohydrates; nutritional models; rumen; simulation
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: September 9, 2019

2007 journal article

Development of a mechanistic model to represent the dynamics of liquid flow out of the rumen and to predict the rate of passage of liquid in dairy cattle

Journal of Dairy Science, 90(2), 840–855. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247890082&partnerID=MN8TOARS

By: S. Seo, C. Lanzas, L. Tedeschi & D. Fox

Contributors: S. Seo, C. Lanzas, L. Tedeschi & D. Fox

Source: ORCID
Added: September 9, 2019

2007 journal article

Digestion kinetics of dried cereal grains

Animal Feed Science and Technology, 136(3-4), 265–280.

By: C. Lanzas*, D. Fox* & A. Pell*

Contributors: C. Lanzas*, D. Fox* & A. Pell*

author keywords: fermentation rates; cereal grains; gas production; feed variation; CNCPS
Source: ORCID
Added: September 9, 2019

2007 journal article

Evaluation of protein fractionation systems used in formulating rations for dairy cattle

Journal of Dairy Science, 90(1), 507–521. http://www.scopus.com/inward/record.url?eid=2-s2.0-35748969906&partnerID=MN8TOARS

By: C. Lanzas, L. Tedeschi, S. Seo & D. Fox

Contributors: C. Lanzas, L. Tedeschi, S. Seo & D. Fox

Source: ORCID
Added: September 9, 2019

2006 journal article

Development and evaluation of empirical equations to predict feed passage rate in cattle

Animal Feed Science and Technology, 128(1-2), 67–83.

By: S. Seo*, L. Tedeschi*, C. Lanzas*, C. Schwab* & D. Fox*

Contributors: S. Seo*, L. Tedeschi*, C. Lanzas*, C. Schwab* & D. Fox*

author keywords: passage rate; meta-analysis; empirical model; model comparison; CNCPS
Source: ORCID
Added: September 9, 2019

Employment

Updated: July 29th, 2015 16:26

2015 - present

North Carolina State University Raleigh, NC, US

Funding History

Funding history based on the linked ORCID record. Updated: November 12th, 2021 15:56

grant September 1, 2020 - August 31, 2025
Automated Data Collection on Antimicrobial Use in Dogs and Cats in a Tertiary Hospital and Private Practices
United States Food and Drug Administration
grant August 1, 2020 - July 31, 2025
Multi-scale modeling and phylodynamics for healthcare associated infections
National Center for Emerging and Zoonotic Infectious Diseases
grant January 1, 2020 - December 31, 2024
Analytical pipelines for data and model integration: finding informed pathways for antimicrobial resistance control
National Institute of General Medical Sciences
grant August 1, 2015 - July 31, 2019
Exposure heterogeneity & environmental transmission dynamics of Escherichia coli
National Institute of General Medical Sciences
grant August 1, 2014 - April 30, 2018
Modeling and control of environmentally transmitted pathogens
National Institute of General Medical Sciences
grant January 21, 2014 - December 31, 2015
Shiga-toxigenic Escherichia coli (STEC) in the Beef Chain: Assessing and Mitigating the Risk by Translational Science, Education and Outreach
United States Department of Agriculture

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