@article{ansari_hughes_husain_2016, title={Ligand-Mediated Toxicology: Characterization and Translational Prospects}, ISBN={["978-3-319-27447-8"]}, ISSN={["2168-4219"]}, DOI={10.1007/978-3-319-27449-2_4}, journal={TRANSLATIONAL TOXICOLOGY: DEFINING A NEW THERAPEUTIC DISCIPLINE}, author={Ansari, Rais and Hughes, Claude L. and Husain, Kazim}, year={2016}, pages={113–137} }
 @article{hughes_waters_allen_obasanjo_2016, title={The Opportunity to Translate Developmental Toxicology into a Therapeutic Discipline}, ISBN={["978-3-319-27447-8"]}, ISSN={["2168-4219"]}, DOI={10.1007/978-3-319-27449-2_1}, abstractNote={Since presentation of our view of translational developmental toxicology in 2013, numerous investigations from a wide range of approaches have added to the evidence underlying our core premise; namely that as the potential adverse developmental effects from a range of exposures are progressively defined, preventative or mitigative therapies can be conceived, assessed and ethically implemented. The spectrum of studies reported in recent years span a wide range of exposure categories and various developmental outcomes ranging from molecular and cellular to the organismal level up to and including human behavior. Since human exposures to chemicals, physical agents and social factors are inevitable, the human fetus is subject to effects that can have lifelong consequences. In order to apply the translational concept to developmental toxicology, established or potential therapeutic obstetrical, neonatal, childhood and adolescent interventions will be required. Those that undergo testing during developmentally sensitive intervals will likely derive from generally-regarded-as-safe (GRAS) or well-established/repurposed pharmaceutical options. Ultimately if we are to translate environmental health discoveries into safe and effective interventions, we must assert and characterize valid, applicable therapies such as GRAS treatments and eventually “ethical pharmaceuticals” for the protective care of these highly vulnerable young people. We can create a safe and efficacious environmental health portfolio of interventional options to improve human health that include both reduction/avoidance of exposure and specific preventative/mitigative/restorative therapeutics. In this chapter we will broadly update new insights that have been gained over the last 2 years regarding the progress of translational developmental toxicology toward becoming a therapeutic discipline.}, journal={TRANSLATIONAL TOXICOLOGY: DEFINING A NEW THERAPEUTIC DISCIPLINE}, author={Hughes, Claude L. and Waters, Michael D. and Allen, David and Obasanjo, Iyabo}, year={2016}, pages={3–44} }
 @article{gannon_sadeu_agarwal_hughes_foster_2014, title={Cigarette smoking and ovarian function}, journal={Ovarian Toxicology, 2nd Edition}, author={Gannon, A. M. and Sadeu, J. C. and Agarwal, S. K. and Hughes, C. L. and Foster, W. G.}, year={2014}, pages={229–248} }
 @article{hendrix_hughes_selgrade_2014, title={Modeling Endocrine Control of the Pituitary-Ovarian Axis: Androgenic Influence and Chaotic Dynamics}, volume={76}, ISSN={["1522-9602"]}, DOI={10.1007/s11538-013-9913-7}, number={1}, journal={BULLETIN OF MATHEMATICAL BIOLOGY}, author={Hendrix, Angelean O. and Hughes, Claude L. and Selgrade, James F.}, year={2014}, month={Jan}, pages={136–156} }
 @article{li_zhu_niu_shi_hughes_tian_huang_2013, title={Effects of Dietary Chromium Methionine on Growth Performance, Carcass Composition, Meat Colour and Expression of the Colour-related Gene Myoglobin of Growing-finishing Pigs}, volume={26}, ISSN={["1976-5517"]}, DOI={10.5713/ajas.2013.13012}, abstractNote={To investigate the effect of dietary chromium (Cr) as Cr methionine (CrMet) on growth performance, carcass traits, pork quality, meat colour and expression of meat colour-related genes in growing-finishing pigs, 189 crossbred Duroc×(Landrace×Yorkshire) growing-finishing pigs (male, castrated, average initial BW 74.58±1.52 kg) were selected and randomly allocated into four groups. Dietary treatments per kg of feed were as follows: 0 (CT), 0.3 mg/kg (T1), 0.6 mg/kg (T2) and 0.9 mg/kg (T3) Cr (in the form of CrMet; as-fed basis), and each treatment was replicated five times with 8 to 10 pigs per replicate pen. During the 28 d of the experiment, both the ADG and the ADFI increased linearly (p<0.05) as the level of dietary Cr increased. The F/G ratio decreased linearly (p<0.05). As dietary Cr increased, loin muscle areas (linear, p = 0.013) and average backfat thickness (linear, p = 0.072) decreased. Shear force (linear, p = 0.070) and Commission Internationale de I'Éclairage (CIE) redness (quadratic, p = 0.028) were increased. In addition, CIE Lightness (quadratic, p = 0.053) were decreased as dietary Cr increased. As dietary Cr increased, total myglobin (Mb) content (quadratic, p = 0.015) and the mb mRNA levels (quadratic, p = 0.046) in longissimus muscles of pigs were up-regulated. In conclusion, supplementation of dietary Cr improved growth and meat colour, but increased shear force and decreased IMF reduced palatability of longissimus muscles. Moreover, the increasing total Mb content and mb mRNA levels indicated that CrMet dietary supplementation may improve meat colour via up-regulating expression of the mb gene.}, number={7}, journal={ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES}, author={Li, Y. S. and Zhu, N. H. and Niu, P. P. and Shi, F. X. and Hughes, C. L. and Tian, G. X. and Huang, R. H.}, year={2013}, month={Jul}, pages={1021–1029} }