Chen Li
College of Engineering
Works (9)
Updated: September 26th, 2024 15:54
2023 journal article
COMBINe enables automated detection and classification of neurons and astrocytes in tissue-cleared mouse brains
CELL REPORTS METHODS, 3(4).
MeSH headings : Animals; Mice; Astrocytes; Excipients; Microscopy, Fluorescence; Neurons; Prosencephalon
TL;DR:
An automated workflow to map sparsely labeled neurons and astrocytes in genetically distinct mouse forebrains using mosaic analysis with double markers (MADM) is presented and the regional and subregional effects of MADM-based deletion of the epidermal growth factor receptor (EGFR) are quantitatively analyzed.
(via Semantic Scholar)
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 30, 2023
2023 journal article
Deep learning-based adaptive optics for light sheet fluorescence microscopy
BIOMEDICAL OPTICS EXPRESS, 14(6), 2905–2919.
TL;DR:
It is shown that the application of correction using a deformable mirror greatly improves image quality and two conceptually different network architectures are compared; one that shares convolutional features and another that estimates each aberration independently.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 24, 2023
2023 journal article
Tissue clearing and three-dimensional imaging of the whole cochlea and vestibular system from multiple large-animal models
STAR PROTOCOLS, 4(2).
author keywords: imaged cochleae using open -source software.; several mm; larger animal inner; open -source software
TL;DR:
A protocol that enables three-dimensional (3D) characterization of intact inner ears from large-animal models is presented and a pipeline to count hair cells in antibody-stained and 3D imaged cochleae using open-source software is detailed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 5, 2023
2022 journal article
Illumination angle correction during image acquisition in light-sheet fluorescence microscopy using deep learning
BIOMEDICAL OPTICS EXPRESS, 13(2), 888–901.
TL;DR:
This study provides a framework that can correct the angle of the light-sheet and improve the overall image quality in high-resolution LSFM 3D image acquisition.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 14, 2022
2022 journal article
Ontogeny of cellular organization and LGR5 expression in porcine cochlea revealed using tissue clearing and 3D imaging
ISCIENCE, 25(8).
TL;DR:
Data reveal that hair cell organization, inner ear morphology, cellular cartography in the organ of Corti, and spatiotemporal expression of LGR5 are dynamic over developmental stages in a pattern not previously documented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 19, 2022
2022 journal article
Quantitative analysis of illumination and detection corrections in adaptive light sheet fluorescence microscopy
BIOMEDICAL OPTICS EXPRESS, 13(5), 2960–2974.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 31, 2022
2021 journal article
Deep learning-based autofocus method enhances image quality in light-sheet fluorescence microscopy
BIOMEDICAL OPTICS EXPRESS, 12(8), 5214–5226.
TL;DR:
A deep learning-based autofocus framework that can estimate the position of the objective-lens focal plane relative to the light-sheet, based on two defocused images is presented, which outperforms or provides comparable results with the best traditional aut ofocus method on small and large image patches respectively.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 16, 2021
2021 article
Deep learning-based autofocus method enhances image quality in light-sheet fluorescence microscopy: publishers note (vol 12, pg 5214, 2021)
LI, C., Moatti, A., Zhang, X., Ghashghaei, H. T., & Greenbaum, A. (2022, January 1). BIOMEDICAL OPTICS EXPRESS, Vol. 13, pp. 373–373.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 10, 2022
2020 journal article
Three-dimensional imaging of intact porcine cochlea using tissue clearing and custom-built light-sheet microscopy
BIOMEDICAL OPTICS EXPRESS, 11(11), 6181–6196.
TL;DR:
3D microscopic analysis was performed on an intact cochlea of newborn and juvenile pigs with a volume up to ∼ 250 mm3 using the BoneClear tissue clearing technique, which renders the bone transparent, to support the growing effort to regenerate cochlear tissues and assist with basic research to advance cures for hearing impairments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 11, 2020
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