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Chelsea Mahn

Works (5)

Updated: June 3rd, 2024 08:14

2024 personal communication

Reply to: On the statistical foundation of a recent single molecule FRET benchmark

Goetz, M., Barth, A., Bohr, S. S.-R., Boerner, R., Chen, J., Cordes, T., … Schmid, S. (2024, April 30).

By: M. Goetz, A. Barth *, S. Bohr *, R. Boerner, J. Chen *, T. Cordes *, D. Erie *, C. Gebhardt * ...

topics (OpenAlex): Molecular Junctions and Nanostructures; Force Microscopy Techniques and Applications; Advanced Fluorescence Microscopy Techniques
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Sources: Web Of Science, NC State University Libraries
Added: May 28, 2024

2023 journal article

Frustration Between Preferred States of Complementary Trinucleotide Repeat DNA Hairpins Anticorrelates with Expansion Disease Propensity

JOURNAL OF MOLECULAR BIOLOGY, 435(10).

By: P. Xu  n, J. Zhang  n, F. Pan n, C. Mahn n, C. Roland n, C. Sagui n, K. Weninger n 

author keywords: single molecule FRET; hairpin slippage; molecular dynamics; kinetics; trinucleotide interrupts; Huntington's disease
MeSH headings : Humans; DNA / genetics; DNA / chemistry; DNA, Complementary; Nucleic Acid Conformation; Trinucleotide Repeat Expansion / genetics; Trinucleotide Repeats; Neurodegenerative Diseases / genetics
topics (OpenAlex): Genetic Neurodegenerative Diseases; RNA Research and Splicing; Mitochondrial Function and Pathology
TL;DR: Single molecule FRET experiments and molecular dynamics simulations are applied to determine conformational stabilities and slipping dynamics for CAG, CTG, GAC and GTC hairpins to determine Tetraloops and TTG interrupts near the loop in the CTG hairpin stabilize the hairpin against slipping. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: May 22, 2023

2022 journal article

A blind benchmark of analysis tools to infer kinetic rate constants from single-molecule FRET trajectories

NATURE COMMUNICATIONS, 13(1).

By: M. Goetz, A. Barth *, S. Bohr *, R. Boerner, J. Chen *, T. Cordes *, D. Erie *, C. Gebhardt * ...

MeSH headings : Benchmarking; Fluorescence Resonance Energy Transfer / methods; Kinetics; Models, Theoretical
topics (OpenAlex): ATP Synthase and ATPases Research; Advanced Fluorescence Microscopy Techniques; Advanced Electron Microscopy Techniques and Applications
TL;DR: A blind benchmark study assessing eleven analysis tools used to infer kinetic rate constants from smFRET trajectories, testing on simulated and experimental data and identifying key targets for future developments to advance the understanding of biomolecular dynamics. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: October 3, 2022

2022 journal article

Tracking the complete degradation lifecycle of poly(ethyl cyanoacrylate): From induced photoluminescence to nitrogen-doped nano-graphene precursor residue

POLYMER DEGRADATION AND STABILITY, 195.

By: D. Fontecha n, C. Mahn n, J. Bochinski n  & L. Clarke n 

author keywords: Polyethylcyanoacrylate; Polymer degradation; Photoluminescence; Amorphous carbon; Graphene; Nitrogen-substituted graphene
topics (OpenAlex): Graphene and Nanomaterials Applications; Graphene research and applications; Polymer Nanocomposite Synthesis and Irradiation
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Sources: Web Of Science, NC State University Libraries
Added: December 6, 2021

2021 journal article

TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA

NUCLEIC ACIDS RESEARCH, 49(22), 13000–13018.

By: P. Kaur n, R. Barnes *, H. Pan n, A. Detwiler *, M. Liu n, C. Mahn n, J. Hall n , Z. Messenger n ...

MeSH headings : Animals; DNA / chemistry; DNA / genetics; DNA / metabolism; HeLa Cells; Humans; Mice, Inbred C57BL; Microscopy, Atomic Force; Nucleic Acid Conformation; Protein Binding; Shelterin Complex / genetics; Shelterin Complex / metabolism; Telomere / genetics; Telomere / metabolism; Telomere-Binding Proteins / genetics; Telomere-Binding Proteins / metabolism; Telomeric Repeat Binding Protein 2 / genetics; Telomeric Repeat Binding Protein 2 / metabolism
topics (OpenAlex): Telomeres, Telomerase, and Senescence; Advanced biosensing and bioanalysis techniques; DNA Repair Mechanisms
TL;DR: A molecular model in which TIN2 functions as an architectural protein to promote TRF2-mediated trans and cis higher-order nucleic acid structures at telomeres is proposed. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 18, 2022

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