Works (4)
Updated: July 4th, 2023 21:20
2023 journal article
Frustration Between Preferred States of Complementary Trinucleotide Repeat DNA Hairpins Anticorrelates with Expansion Disease Propensity
JOURNAL OF MOLECULAR BIOLOGY, 435(10).
author keywords: single molecule FRET; hairpin slippage; molecular dynamics; kinetics; trinucleotide interrupts; Huntington's disease
MeSH headings : Humans; DNA / genetics; DNA / chemistry; DNA, Complementary; Nucleic Acid Conformation; Trinucleotide Repeat Expansion / genetics; Trinucleotide Repeats; Neurodegenerative Diseases / genetics
TL;DR:
Single molecule FRET experiments and molecular dynamics simulations are applied to determine conformational stabilities and slipping dynamics for CAG, CTG, GAC and GTC hairpins to determine Tetraloops and TTG interrupts near the loop in the CTG hairpin stabilize the hairpin against slipping.
(via Semantic Scholar)
zenodo.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: May 22, 2023
2022 journal article
A blind benchmark of analysis tools to infer kinetic rate constants from single-molecule FRET trajectories
NATURE COMMUNICATIONS, 13(1).
MeSH headings : Benchmarking; Fluorescence Resonance Energy Transfer / methods; Kinetics; Models, Theoretical
TL;DR:
A blind benchmark study assessing eleven analysis tools used to infer kinetic rate constants from smFRET trajectories, testing on simulated and experimental data and identifying key targets for future developments to advance the understanding of biomolecular dynamics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: October 3, 2022
2022 journal article
Tracking the complete degradation lifecycle of poly(ethyl cyanoacrylate): From induced photoluminescence to nitrogen-doped nano-graphene precursor residue
POLYMER DEGRADATION AND STABILITY, 195.
author keywords: Polyethylcyanoacrylate; Polymer degradation; Photoluminescence; Amorphous carbon; Graphene; Nitrogen-substituted graphene
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: December 6, 2021
2021 journal article
TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA
NUCLEIC ACIDS RESEARCH, 49(22), 13000–13018.
MeSH headings : Animals; DNA / chemistry; DNA / genetics; DNA / metabolism; HeLa Cells; Humans; Mice, Inbred C57BL; Microscopy, Atomic Force; Nucleic Acid Conformation; Protein Binding; Shelterin Complex / genetics; Shelterin Complex / metabolism; Telomere / genetics; Telomere / metabolism; Telomere-Binding Proteins / genetics; Telomere-Binding Proteins / metabolism; Telomeric Repeat Binding Protein 2 / genetics; Telomeric Repeat Binding Protein 2 / metabolism
TL;DR:
A molecular model in which TIN2 functions as an architectural protein to promote TRF2-mediated trans and cis higher-order nucleic acid structures at telomeres is proposed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: January 18, 2022
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