Christopher Martin Brackett

Works (3)

Updated: July 5th, 2023 15:42

2019 article

Small Molecule Potentiation of Gram-Positive Selective Antibiotics against Acinetobacter baumannii

Martin, S. E., Melander, R. J., Brackett, C. M., Scott, A. J., Chandler, C. E., Nguyen, C. M., … Melander, C. (2019, April 19). ACS Infectious Diseases.

By: S. Martin*, R. Melander*, C. Brackett n, A. Scott *, C. Chandler *, C. Nguyen  n, B. Minrovic*, S. Harrill n ...

author keywords: antibiotic adjuvant; antibiotic resistance; Acinetobacter baumannii; macrolide antibiotics; glycopeptide antibiotics; lipopolysaccharide
MeSH headings : Acinetobacter Infections / drug therapy; Acinetobacter baumannii / drug effects; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacology; Bacterial Outer Membrane / drug effects; Disease Models, Animal; Drug Resistance, Multiple, Bacterial / drug effects; Drug Synergism; Glycopeptides / administration & dosage; Glycopeptides / pharmacology; Macrolides / administration & dosage; Macrolides / pharmacology; Microbial Sensitivity Tests; Moths; Small Molecule Libraries / administration & dosage; Small Molecule Libraries / pharmacology
topics (OpenAlex): Antimicrobial Peptides and Activities; Antibiotic Resistance in Bacteria; Invertebrate Immune Response Mechanisms
TL;DR: Two adjuvant compounds are identified that dramatically enhance sensitivity of Acinetobacter baumannii to macrolide and glycopeptide antibiotics, with reductions in minimum inhibitory concentrations as high as 256-fold, and mode of action studies indicate that these adjuvants likely work by modulating lipopolysaccharide synthesis or assembly. (via Semantic Scholar)
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Source: Web Of Science
Added: August 5, 2019

2015 article

Second generation modifiers of colistin resistance show enhanced activity and lower inherent toxicity

Brackett, C. M., Furlani, R. E., Anderson, R. G., Krishnamurthy, A., Melander, R. J., Moskowitz, S. M., … Melander, C. (2015, September 8). Tetrahedron.

By: C. Brackett n, R. Furlani n, R. Anderson  n, A. Krishnamurthy n, R. Melander n, S. Moskowitz *, R. Ernst *, C. Melander n

author keywords: Antibiotic adjuvant; 2-Aminoimidazole; Colistin; ESKAPE pathogens; Acinetobacter baumannii; Pseudomonas aeruginosa
topics (OpenAlex): Antibiotic Resistance in Bacteria; Cancer therapeutics and mechanisms; Pharmaceutical and Antibiotic Environmental Impacts
TL;DR: From these libraries, a new small molecule was identified that lowers the minimum inhibitory concentration of colistin by up to 32-fold greater than the parent compound while also displaying less inherent bacterial effect, thereby minimizing the likelihood of resistance evolution. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2014 article

Small-Molecule Suppression of β-Lactam Resistance in Multidrug-Resistant Gram-Negative Pathogens

Brackett, C. M., Melander, R. J., An, I. H., Krishnamurthy, A., Thompson, R. J., Cavanagh, J., & Melander, C. (2014, August 19). Journal of Medicinal Chemistry.

By: C. Brackett n, R. Melander n, I. An n, A. Krishnamurthy n, R. Thompson n, J. Cavanagh n, C. Melander n

MeSH headings : Animals; Cell Line; Cell Survival / drug effects; Drug Resistance, Multiple, Bacterial / drug effects; Gram-Negative Bacteria / classification; Gram-Negative Bacteria / drug effects; Hemolysis / drug effects; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Microbial Sensitivity Tests; Sheep; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology; beta-Lactam Resistance / drug effects
topics (OpenAlex): Antibiotic Resistance in Bacteria; Cancer therapeutics and mechanisms; Antibiotics Pharmacokinetics and Efficacy
TL;DR: A small molecule was identified from this library of aryl amide 2-aminoimidazoles that is capable of lowering the minimum inhibitory concentration of β-lactam antibiotics by up to 64-fold. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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