Works (37)

Updated: April 5th, 2024 11:03

2022 journal article

Prolonged oral antimicrobial administration prevents doxorubicin-induced loss of active intestinal stem cells

GUT MICROBES, 14(1).

By: B. Sheahan n, C. Theriot n, J. Cortes n & C. Dekaney n

author keywords: Microbiota; intestinal stem cells; doxorubicin; antibiotics; antimicrobials; DNA damage; germ free; injury; small intestine
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacology; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / adverse effects; Bacteria / classification; Bacteria / drug effects; Bacteria / genetics; Bacteria / isolation & purification; Cell Survival / drug effects; Doxorubicin / administration & dosage; Doxorubicin / adverse effects; Gastrointestinal Microbiome / drug effects; Germ-Free Life; Humans; Jejunum / cytology; Jejunum / drug effects; Jejunum / microbiology; Mice; Mice, Inbred C57BL; Mucositis / microbiology; Mucositis / prevention & control; Stem Cells / cytology; Stem Cells / drug effects; Time Factors
TL;DR: Pro-survival signaling from microbiota in AMBx-treated mice to the aISCs is suggested, and that this signaling maintains aISC retention in the face of chemotherapeutic injury. (via Semantic Scholar)
Source: Web Of Science
Added: January 18, 2022

2021 journal article

Epithelial Regeneration After Doxorubicin Arises Primarily From Early Progeny of Active Intestinal Stem Cells

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 12(1), 119–140.

By: B. Sheahan n, A. Freeman n, T. Keeley*, L. Samuelson*, J. Roper*, S. Hasapis*, C. Lee*, C. Dekaney n

author keywords: Gastrointestinal; irradiation; LGR5; DNA damage response
MeSH headings : Antibiotics, Antineoplastic / pharmacology; Apoptosis / drug effects; Doxorubicin / pharmacology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Epithelial Cells / pathology; Humans; Intestines / drug effects; Intestines / metabolism; Regeneration / drug effects; Stem Cells / drug effects; Stem Cells / metabolism; Stem Cells / pathology
TL;DR: It is shown that DXR effectively depleted aISCs in the small intestine and subsequent epithelial regeneration depended on nonquiescent early progeny cells of a ISCs, which may rely on a dampened DDR in contrast to aISCS’ robust DDR, which facilitates expeditious apoptosis. (via Semantic Scholar)
Source: Web Of Science
Added: August 16, 2021

2021 article

Hyperproliferation of the Intestinal Epithelium

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, Vol. 12, pp. 1145–1146.

By: C. Dekaney n

MeSH headings : Intestinal Mucosa
TL;DR: How an activating mutation in HER2, a member of the EGF receptor family, impacts small intestinal and colonic architecture, expression of stem cell genes, lineage allocation, and stem cell functionality via enteroid and colonoid cultures is explored. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: September 20, 2021

2021 journal article

Multiomic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals novel markers of almost all major cell types

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 321(6), G668–G681.

By: M. Shanahan*, M. Kanke*, O. Oyesola*, Y. Hung*, K. Koch-Laskowski*, A. Singh*, B. Peck*, M. Biraud n ...

author keywords: intestinal epithelium; marker; microRNA; Paneth; tuft
MeSH headings : Animals; Biomarkers / metabolism; Cell Lineage; Cell Separation; Cells, Cultured; Computational Biology; Dogs; Epithelial Cells / metabolism; Female; Flow Cytometry; Gene Expression Profiling; Intestinal Mucosa / cytology; Intestinal Mucosa / metabolism; Intestine, Small / cytology; Intestine, Small / metabolism; Male; Mice, Inbred C57BL; Mice, Transgenic; MicroRNAs / genetics; MicroRNAs / metabolism; Organoids; RNA-Seq; Single-Cell Analysis; Transcriptome
TL;DR: Comprehensive microRNA profiling in all major cell types of the mouse SI epithelium revealed highly enriched microRNA markers for almost every major cell type, and observed that the two most-enriched microRNAs in secretory progenitors are miR-1224 andMiR-672, the latter of which is deleted in hominin species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 3, 2022

2021 review

Secretory Sorcery: Paneth Cell Control of Intestinal Repair and Homeostasis

[Review of ]. CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 12(4), 1239–1250.

By: P. Cray n, B. Sheahan n & C. Dekaney n

author keywords: Paneth cells; damage; intestine; ER stress; reversion
MeSH headings : Animals; Cell Differentiation; Cellular Microenvironment; Crohn Disease / etiology; Crohn Disease / metabolism; Crohn Disease / pathology; Disease Susceptibility; Homeostasis; Host Microbial Interactions; Humans; Intestinal Mucosa / microbiology; Intestinal Mucosa / physiology; Microbiota; Paneth Cells / physiology; Regeneration; Signal Transduction; Stem Cells / cytology; Stem Cells / metabolism; Wound Healing
TL;DR: The numerous ways Paneth cells can influence intestinal stem cells and their niche are discussed and the ways in which these cells can alter cells and other organ systems are highlighted. (via Semantic Scholar)
Source: Web Of Science
Added: November 8, 2021

2020 journal article

Doxorubicin increases permeability of murine small intestinal epithelium and cultured T84 monolayers

SCIENTIFIC REPORTS, 10(1).

By: P. Cray n, B. Sheahan n, J. Cortes n & C. Dekaney n

MeSH headings : Animals; Cell Line; Cell Membrane Permeability / drug effects; Doxorubicin / metabolism; Doxorubicin / pharmacology; Duodenum / metabolism; Epithelium / metabolism; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestine, Small / drug effects; Intestine, Small / metabolism; Jejunum / metabolism; Male; Mice; Mice, Inbred C57BL; Permeability / drug effects; Tight Junctions / metabolism
TL;DR: DXR increases paracellular transit of small macromolecules, including bacterial products, through the epithelium, by altering expression of tight junctional components and dynamic loosening of cellular tight junctions. (via Semantic Scholar)
Source: Web Of Science
Added: January 11, 2021

2020 journal article

Enteroendocrine Progenitor Cell-Enriched mir-7 Regulates Intestinal Epithelial Proliferation in an Xiap-Dependent Manner

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 9(3), 447–464.

By: A. Singh*, Y. Hung*, M. Shanahan*, M. Kanke*, A. Bonfini*, M. Dame*, M. Biraud n, B. Peck* ...

author keywords: miR-7; Enteroendocrine Lineage; Small Intestine; Enteroid; Proliferation
MeSH headings : Animals; Cell Lineage / genetics; Cell Proliferation / genetics; Cells, Cultured; Computational Biology; Enteroendocrine Cells / physiology; ErbB Receptors / metabolism; Feeding Behavior / physiology; Female; Inhibitor of Apoptosis Proteins / genetics; Inhibitor of Apoptosis Proteins / metabolism; Intestinal Mucosa / cytology; Intestinal Mucosa / physiology; Male; Mice; Mice, Transgenic; MicroRNAs / metabolism; Models, Animal; Organoids; Primary Cell Culture; RNA-Seq; Signal Transduction / genetics; Single-Cell Analysis; Stem Cells / physiology
TL;DR: This study demonstrates for the first time that EEC progenitor cell-enriched miR-7 is altered by dietary perturbations and that it regulates growth in enteroids via intact Xiap and Egfr signaling. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 6, 2020

2019 journal article

Cellular Plasticity of Defa4(Cre)-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 7(3), 533–554.

By: J. Jones*, C. Brindley, N. Elder, M. Myers*, M. Rajala*, C. Dekaney n, E. McNamee*, M. Frey*, N. Shroyer*, P. Dempsey*

author keywords: Defensin; Paneth Cell; Intestinal Stem Cells; Regeneration; Enteroid; Notch; Chemotherapy
MeSH headings : ADAM10 Protein / metabolism; Adenoma / pathology; Adenomatous Polyposis Coli Protein / metabolism; Alleles; Animals; Cell Dedifferentiation; Cell Lineage; Cell Plasticity; Clone Cells; Doxorubicin; Gene Deletion; Homeostasis; Hyperplasia; Integrases / metabolism; Intestines / injuries; Intestines / pathology; Mice; Mitosis; Multipotent Stem Cells / metabolism; Organoids / growth & development; Organoids / pathology; Paneth Cells / metabolism; Receptors, Notch / metabolism; Regeneration; alpha-Defensins / metabolism
TL;DR: The studies have shown that Defa4Cre-expressing Paneth cells possess cellular plasticity, can dedifferentiate into multipotent stem cells upon Notch activation, and can contribute to intestinal regeneration in an acute injury model. (via Semantic Scholar)
Source: Web Of Science
Added: May 6, 2019

2019 journal article

Mist1 Expression Is Required for Paneth Cell Maturation

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 8(4), 549–560.

By: C. Dekaney n, S. King n, B. Sheahan n & J. Cortes n

author keywords: MIST1; Paneth Cells; Intermediate Cells
MeSH headings : Animals; Basic Helix-Loop-Helix Transcription Factors / biosynthesis; Basic Helix-Loop-Helix Transcription Factors / genetics; Basic Helix-Loop-Helix Transcription Factors / metabolism; Cell Differentiation / physiology; Cell Division / physiology; Cell Lineage; Endoplasmic Reticulum Stress; Endoplasmic Reticulum, Rough / physiology; Epithelium / metabolism; Female; Intestinal Mucosa / metabolism; Intestine, Small / physiology; Intestines / physiology; Mice; Mice, Knockout; Paneth Cells / metabolism; Paneth Cells / physiology; Signal Transduction; Stem Cells / cytology; Stem Cells / metabolism; Transcriptome
TL;DR: MIST1 plays an important role in organization of the Paneth cell secretory apparatus and managing endoplasmic reticulum stress, which occurs downstream ofPaneth cell lineage allocation. (via Semantic Scholar)
Source: Web Of Science
Added: December 16, 2019

2018 article

Decrypting the Crypt: Novel Monoclonal Antibodies to Identify Intestinal Stem Cell Populations

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, Vol. 6, pp. 121–122.

By: B. Sheahan n & C. Dekaney n

TL;DR: The investigators were successfully able to prove, via single-cell growth analyses, immunofluorescence, and gene expression, that the monoclonal antibody F5C12 marks a population with essentially identical properties to Lgr5 sorted cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Intestinal bacteria are necessary for doxorubicin-induced intestinal damage but not for doxorubicin-induced apoptosis

Gut Microbes, 7(5), 414–423.

By: R. Rigby*, J. Carr*, K. Orgel*, S. King n, P. Lund* & C. Dekaney n

author keywords: apoptosis; bacteria; damage; doxorubicin; germ free; intestine
MeSH headings : Animals; Antibiotics, Antineoplastic / administration & dosage; Antibiotics, Antineoplastic / adverse effects; Apoptosis / drug effects; Bacteria / drug effects; Bacteria / genetics; Bacteria / isolation & purification; Doxorubicin / administration & dosage; Doxorubicin / adverse effects; Female; Gastrointestinal Microbiome / drug effects; Germ-Free Life; Goblet Cells / drug effects; Goblet Cells / microbiology; Intestines / cytology; Intestines / drug effects; Intestines / microbiology; Mice; Mice, Inbred C57BL; Paneth Cells / drug effects; Paneth Cells / microbiology
TL;DR: Findings provide evidence that manipulation and/or depletion of the enteric microbiota may have clinical significance in limiting chemotherapy-induced mucositis. (via Semantic Scholar)
Source: Crossref
Added: February 21, 2020

2015 journal article

1009 Depletion of Enteric Microbiota Protects from Chemotherapy-Induced Damage in the Murine Small Intestine

Gastroenterology, 148(4), S-1132.

By: J. Carr, S. King & C. Dekaney*

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: February 21, 2020

2015 journal article

798 Mist1 Is Necessary for Paneth Cell Maturation

Gastroenterology, 148(4), S-156-S-157.

By: S. King, J. Carr & C. Dekaney*

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: February 21, 2020

2015 journal article

Tissue underlying the intestinal epithelium elicits proliferation of intestinal stem cells following cytotoxic damage

Cell and Tissue Research, 361(2), 427–438.

By: K. Seiler*, E. Schenhals*, R. von Furstenberg*, B. Allena*, B. Smith*, D. Scaria*, M. Bresler*, C. Dekaney*, S. Henning*

author keywords: Doxorubicin damage; Intestinal stem cells; Chordin-like 2; Subepithelial tissue; Amphiregulin; BMP antagonists
MeSH headings : Amphiregulin / metabolism; Animals; Antibiotics, Antineoplastic / toxicity; Carrier Proteins / metabolism; Cell Proliferation; Cells, Cultured; Doxorubicin / toxicity; Extracellular Matrix Proteins; Intestines / cytology; Intestines / drug effects; Intestines / pathology; Intestines / physiology; Male; Mice, Inbred C57BL; Regeneration; Stem Cells / cytology
TL;DR: A critical role for underlying tissue in regulating ISC behavior after damage is suggested, and synergism between amphiregulin and chordin-like 2 as factors which may account for activation of ISCs in the regenerative phase are pointed to. (via Semantic Scholar)
Source: Crossref
Added: July 20, 2019

2013 journal article

Mo1824 Jejunal and Ileal Epithelium Demonstrate Differing Damage Responses to Doxorubicin Treatment

Gastroenterology, 144(5), S-672.

By: K. Gewain, S. King & C. Dekaney*

Source: Crossref
Added: March 13, 2020

2013 journal article

Paneth cells expand from newly created and preexisting cells during repair after doxorubicin-induced damage

American Journal of Physiology-Gastrointestinal and Liver Physiology, 305(2), G151–G162.

By: S. King*, J. Mohiuddin* & C. Dekaney*

author keywords: Paneth cell; doxorubicin; intermediate cell
MeSH headings : Animals; Antibiotics, Antineoplastic / toxicity; Doxorubicin / toxicity; Female; Fibroblast Growth Factors / genetics; Fibroblast Growth Factors / metabolism; Intestinal Mucosa / pathology; Intestinal Mucosa / ultrastructure; Intestines / cytology; Intestines / drug effects; Mice; Mice, Inbred C57BL; Paneth Cells / drug effects; Paneth Cells / pathology; RNA, Messenger / genetics; RNA, Messenger / metabolism; Signal Transduction / drug effects; Signal Transduction / physiology; Wnt Proteins / genetics; Wnt Proteins / metabolism; beta Catenin / genetics; beta Catenin / metabolism
TL;DR: Findings are significant, as they provide a first step in understanding mechanisms of Paneth cell expansion during mucosal repair, as these cells express Paneth and goblet biomarkers and are found only during repair. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 20, 2019

2013 journal article

Small Intestinal Stem Cells

Current Opinion in Gastroenterology, 29, 140–145.

By: S. King & C. Dekaney

Source: NC State University Libraries
Added: September 8, 2019

2013 journal article

Tu2027 The Chemotherapeutic Agent Doxorubicin Induces Contrasting Microbial Responses in the Jejunum and Distal Ileum That May Contribute to Differential Injury Patterns

Gastroenterology, 144(5), S-907-S-908.

By: C. Packey, K. Gewain, R. Sartor & C. Dekaney*

Source: Crossref
Added: March 13, 2020

2011 journal article

Characterization Of Intestinal Stem Cells During Development: The Role Of Lgr5

Journal of Surgical Research, 165(2), 339.

By: J. Dehmer*, A. Garrison*, K. Speck*, C. Dekaney*, S. Henning* & M. Helmrath*

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: August 28, 2020

2011 journal article

Expansion of Intestinal Epithelial Stem Cells during Murine Development

PLoS ONE, 6(11), e27070.

By: J. Dehmer*, A. Garrison*, K. Speck*, C. Dekaney*, L. Van Landeghem*, X. Sun*, S. Henning*, M. Helmrath*

Ed(s): M. Rota

MeSH headings : Animals; Biomarkers / metabolism; Cell Lineage; Epithelial Cells / cytology; Epithelial Cells / metabolism; Female; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; In Situ Hybridization; Intestinal Mucosa / metabolism; Intestines / cytology; Male; Mice; Mice, Inbred C57BL; RNA, Messenger / genetics; Real-Time Polymerase Chain Reaction; Receptors, G-Protein-Coupled / genetics; Receptors, G-Protein-Coupled / metabolism; Stem Cells / cytology; Stem Cells / metabolism
TL;DR: It is concluded that heterogeneous populations of ISCs are expanding as measured by SP sorting and mRNA expression at distinct developmental time points. (via Semantic Scholar)
Source: Crossref
Added: July 20, 2019

2010 journal article

750 Germ Free Mice Show Apoptosis but Dramatically Reduced Overt Mucosal Damage After Doxorubicin

Gastroenterology, 138(5), S-103.

By: R. Rigby, P. Lund & C. Dekaney*

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: August 28, 2020

2010 journal article

T1727 Paneth Cells Expand From a Pre-Existing Pool During Repair After Doxorubicin-Induced Damage

Gastroenterology, 138(5), S-566.

By: C. Dekaney*

Source: Crossref
Added: February 12, 2021

2009 journal article

488 Regeneration of Intestinal Stem Cells Following Doxorubicin Treatment of Mice

Gastroenterology, 136(5), A-79.

By: C. Dekaney*, A. Gulati, M. Helmrath & S. Henning

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: August 28, 2020

2009 journal article

Early but not late administration of glucagon-like peptide-2 following ileo-cecal resection augments putative intestinal stem cell expansion

American Journal of Physiology-Gastrointestinal and Liver Physiology, 296(3), G643–G650.

By: A. Garrison, C. Dekaney*, D. von Allmen, P. Lund*, S. Henning* & M. Helmrath

author keywords: intestinal adaptation
MeSH headings : Animals; Cecum / pathology; Cecum / surgery; Cell Division / drug effects; Glucagon-Like Peptide 2 / metabolism; Glucagon-Like Peptide 2 / pharmacology; Ileum / pathology; Ileum / surgery; Insulin-Like Growth Factor I / metabolism; Intestinal Diseases / pathology; Intestinal Diseases / surgery; Male; Mice; Mice, Inbred C57BL; Phosphorylation / drug effects; Postoperative Complications / drug therapy; Postoperative Complications / pathology; Proteins / metabolism; Stem Cells / cytology; Time Factors; Weight Gain / drug effects; beta Catenin / metabolism
TL;DR: This study shows that, in mice, GLP-2 promotes jejunal pISC expansion only in the period immediately following ICR, associated with increased IGF-I and accelerated adaptive increases in mucosal mass. (via Semantic Scholar)
Source: Crossref
Added: July 20, 2019

2009 journal article

Regeneration of intestinal stem/progenitor cells following doxorubicin treatment of mice

American Journal of Physiology-Gastrointestinal and Liver Physiology, 297(3), G461–G470.

By: C. Dekaney*, A. Gulati, A. Garrison, M. Helmrath* & S. Henning*

author keywords: crypt fission; apoptosis; Paneth cells; goblet cells; Lgr5
MeSH headings : Animals; Antibiotics, Antineoplastic / administration & dosage; Antibiotics, Antineoplastic / toxicity; Apoptosis / drug effects; Cell Lineage; Cell Proliferation / drug effects; Doublecortin-Like Kinases; Doxorubicin / administration & dosage; Doxorubicin / toxicity; Female; Injections, Intraperitoneal; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestine, Small / drug effects; Intestine, Small / metabolism; Intestine, Small / pathology; Jejunum / drug effects; Jejunum / pathology; Leukocyte Common Antigens / analysis; Mice; Mice, Inbred C57BL; Mice, Transgenic; Protein Serine-Threonine Kinases / metabolism; RNA, Messenger / metabolism; Receptors, G-Protein-Coupled / genetics; Receptors, G-Protein-Coupled / metabolism; Regeneration / drug effects; Stem Cells / drug effects; Stem Cells / metabolism; Stem Cells / pathology; Time Factors; beta Catenin / metabolism
TL;DR: Together these data suggest that, following Dox-induced injury, expansion of intestinal stem cells occurs during mucosal repair, and appears to be predominantly the +4 stem cell population rather than those of the crypt base. (via Semantic Scholar)
Source: Crossref
Added: July 20, 2019

2008 journal article

163. Timing of Glucagon-Like Peptide-2 (GLP-2) Required for Augmented Expansion of Intestinal Stem Cells Following Ileo-Cecal Resection (ICR) in Mice

Journal of Surgical Research, 144(2), 249–250.

By: A. Garrison*, C. Dekaney*, D. von Allmen*, S. Henning* & M. Helmrath*

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: August 28, 2020

2008 journal article

29. Bacterial Dependent up Regulation of Ileal Bile Acid Binding Protein and Bile Acid Transporters Is FXR-Mediated Following Ileo-Cecal Resection (ICR)

Journal of Surgical Research, 144(2), 188–189.

By: C. Dekaney*, D. von Allmen*, A. Garrison*, R. Rigby*, P. Lund*, S. Henning*, M. Helmrath*

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 28, 2020

2008 journal article

Bacterial-dependent up-regulation of intestinal bile acid binding protein and transport is FXR-mediated following ileo-cecal resection

Surgery, 144(2), 174–181.

By: C. Dekaney*, D. von Allmen*, A. Garrison*, R. Rigby*, P. Lund*, S. Henning*, M. Helmrath*

MeSH headings : Animals; Bile Acids and Salts / metabolism; Biological Transport; Cecum / surgery; Colon / metabolism; Colon / microbiology; DNA-Binding Proteins / physiology; Germ-Free Life; Hydroxysteroid Dehydrogenases / metabolism; Ileum / surgery; Male; Mice; Mice, Inbred C57BL; Organic Anion Transporters, Sodium-Dependent / metabolism; Receptors, Cytoplasmic and Nuclear / physiology; Symporters / metabolism; Transcription Factors / physiology; Up-Regulation
TL;DR: Bacterial dependent up regulation of IBABP is FXR mediated in the colon following ICR, and mice lacking microbiota (GF) or FXR are unable to increase the expression of I BABP or FGF 15. (via Semantic Scholar)
Source: Crossref
Added: July 20, 2019

2008 journal article

Developmental insight into intestinal adaptation: characterization of intestinal stem cell (ISC) expansion and glucagon-like peptide-2 (GLP-2) actions during murine intestinal development

Journal of the American College of Surgeons, 207(3), S55–S56.

By: A. Garrison*, C. Dekaney*, D. von Allmen*, S. Henning* & M. Helmrath*

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: January 21, 2021

2008 journal article

Regulation of ornithine aminotransferase gene expression and activity by all-transretinoic acid in Caco-2 intestinal epithelial cells

The Journal of Nutritional Biochemistry, 19(10), 674–681.

By: C. Dekaney*, G. Wu*, Y. Yin & L. Jaeger*

author keywords: retinoic acid; ornithine aminotransferase; polyamines; intestinal cells
MeSH headings : Biogenic Polyamines / metabolism; Blotting, Northern; Caco-2 Cells; Epithelial Cells / drug effects; Epithelial Cells / enzymology; Epithelial Cells / metabolism; Gene Expression Regulation, Enzymologic / drug effects; Humans; Intestinal Mucosa / metabolism; Intestines / cytology; Intestines / drug effects; Intestines / enzymology; Ornithine-Oxo-Acid Transaminase / genetics; RNA, Messenger / genetics; Tretinoin / pharmacology
TL;DR: Testing the hypothesis that RA regulates OAT mRNA expression and enzymatic activity in intestinal epithelial cells concludes that exposure of Caco-2 cells to RA induces OAT expression for increasing ornithine catabolism, which leads to a reduced availability of intracellular Ornithine for polyamine synthesis, thereby decreasing cell proliferation. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2008 journal article

T1818 Early Administration of Glucagon-Like Peptide-2 (GLP-2) Following Ileocecal Resection Augments Insulin-Like Growth Factor-I (IGF-I) Signaling During Intestinal Stem Cell Expansion

Gastroenterology, 134(4), A-569-A-570.

By: A. Garrison, C. Dekaney*, D. von Allmen, P. Lund, S. Henning & M. Helmrath

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: January 21, 2021

2007 journal article

Expansion of intestinal stem cells associated with long-term adaptation following ileocecal resection in mice

American Journal of Physiology-Gastrointestinal and Liver Physiology, 293(5), G1013–G1022.

By: C. Dekaney*, J. Fong, R. Rigby, P. Lund, S. Henning & M. Helmrath

author keywords: intestinal stem cells; intestinal resection; crypt fission; label retention
MeSH headings : Acclimatization; Animals; Cecum / surgery; Cell Division; Ileum / surgery; Intestinal Mucosa / cytology; Intestinal Mucosa / physiology; Jejunum / cytology; Jejunum / physiology; Male; Mice; Mice, Inbred C57BL; Regeneration; Stem Cells / cytology; Stem Cells / physiology
TL;DR: These studies support that expansion of ISC occurs following ICR, leading to an overall increase number of crypts through a process of fission and intestinal dilation. (via Semantic Scholar)
Source: Crossref
Added: July 20, 2019

2007 journal article

Rapid expansion of intestinal secretory lineages following a massive small bowel resection in mice

American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(1), G215–G222.

By: M. Helmrath, J. Fong, C. Dekaney* & S. Henning*

author keywords: intestinal adaptation; intestinal failure; Paneth cells; goblet cells
MeSH headings : Anastomosis, Surgical; Animals; DNA Primers; Ileum / anatomy & histology; Ileum / physiology; Ileum / surgery; Intestinal Mucosa / metabolism; Intestinal Mucosa / physiology; Intestinal Mucosa / surgery; Intestine, Small / metabolism; Intestine, Small / physiology; Intestine, Small / surgery; Male; Mice; Mice, Inbred C57BL; Microvilli / physiology; Microvilli / ultrastructure; RNA / genetics; RNA / isolation & purification; Reverse Transcriptase Polymerase Chain Reaction; Sucrase-Isomaltase Complex / genetics
TL;DR: It is speculated that early expansion of intestinal secretory lineages within the epithelium of the ileum occurs following SBR, possibly serving to amplify the signal responsible for initiating and sustaining intestinal adaptation. (via Semantic Scholar)
Source: Crossref
Added: July 20, 2019

2006 journal article

Massive small bowel resection results in sustained increases in intestinal stem cell number

Journal of Surgical Research, 130(2), 253.

By: C. Dekaney*, J. Fong*, J. Rodriguez*, S. Henning* & M. Helmrath*

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: August 28, 2020

2006 journal article

Reply

Gastroenterology, 130(3), 1013–1014.

By: C. Dekaney*, J. Rodriguez*, M. Graul* & S. Henning*

Source: Crossref
Added: August 28, 2020

2005 journal article

Isolation and Characterization of a Putative Intestinal Stem Cell Fraction From Mouse Jejunum

Gastroenterology, 129(5), 1567–1580.

By: C. Dekaney*, J. Rodriguez*, M. Graul* & S. Henning*

MeSH headings : Age Factors; Animals; Animals, Newborn; Antigens, CD34 / metabolism; Biomarkers; Cell Fractionation; Cell Separation; Cell Survival; Cells, Cultured; Intestinal Mucosa / cytology; Jejunum / cytology; Leukocyte Common Antigens / metabolism; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Proto-Oncogene Proteins c-kit / metabolism; RNA, Messenger / analysis; RNA-Binding Proteins / genetics; RNA-Binding Proteins / metabolism; Stem Cells / cytology; Stem Cells / metabolism
TL;DR: The CD45-negative SP fraction, although not pure, represents the successful isolation of a viable population significantly enriched in small intestinal epithelial stem cells. (via Semantic Scholar)
Source: Crossref
Added: July 20, 2019

2004 journal article

Early activation of Wnt β-catenin system following a massive small bowel resection in mice

Journal of Surgical Research, 121(2), 309–310.

By: M. Helmrath*, J. Fong*, C. Dekaney* & H. Henning*

TL;DR: Early changes in gene expression of the soluble intestinal Wnts and their downstream targets responsible for proliferation, migration, and differentiation towards secretory lineages in mature epithelium are determined. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

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