Carson Key

Works (2)

Updated: July 5th, 2023 15:18

2021 journal article

Multivalent Aptamer‐Functionalized Single‐Strand RNA Origami as Effective, Target‐Specific Anticoagulants with Corresponding Reversal Agents

Advanced Healthcare Materials, 10(11).

By: A. Krissanaprasit n, C. Key n, K. Froehlich n, S. Pontula, E. Mihalko n, D. Dupont *, E. Andersen *, J. Kjems *, A. Brown n , T. LaBean n

author keywords: anticoagulants; aptamers; direct thrombin inhibitors; nucleic acids; reversal agents; RNA nanotechnology; RNA origami
MeSH headings : Anticoagulants / pharmacology; Aptamers, Nucleotide / pharmacology; Blood Coagulation; RNA / pharmacology; Thrombin
TL;DR: Compared to current commercial intravenous anticoagulants, RNA origami‐based molecules show promise as safer alternatives with rapid activity switching for future therapeutic applications. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: June 10, 2021

2019 journal article

Genetically Encoded, Functional Single-Strand RNA Origami: Anticoagulant

ADVANCED MATERIALS, 31(21).

By: A. Krissanaprasit n, C. Key n, M. Fergione n, K. Froehlich n, S. Pontula, M. Hart n, P. Carriel n, J. Kjems *, E. Andersen *, T. LaBean n

author keywords: anticoagulants; in vitro transcription; nucleic acid nanotechnology; RNA aptamers; RNA origami
MeSH headings : Anticoagulants / chemistry; Anticoagulants / pharmacology; Aptamers, Nucleotide / chemistry; Aptamers, Nucleotide / metabolism; Aptamers, Nucleotide / pharmacology; Humans; Nucleic Acid Conformation; Partial Thromboplastin Time; RNA / chemistry; RNA / pharmacology; Thrombin / antagonists & inhibitors; Thrombin / genetics; Thrombin / metabolism
TL;DR: A family of self‐folding, functional RNA origami molecules bearing multiple thrombin‐binding RNA aptamers and showing significantly improved anticoagulant activity is described, paving the way for development of RNA Origami for potential therapeutic applications especially as a safer surgical anticogulant. (via Semantic Scholar)
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Source: Web Of Science
Added: July 29, 2019

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