Christina M. Williams

Works (14)

Updated: July 5th, 2023 15:47

2022 article

Transcriptome annotation reveals minimal immunogenetic diversity among Wyoming toads, Anaxyrus baxteri

Carlson, K. B., Wcisel, D. J., Ackerman, H. D., Romanet, J., Christiansen, E. F., Niemuth, J. N., … Yoder, J. A. (2022, April 28). Conservation Genetics, Vol. 4.

By: K. Carlson n, D. Wcisel n, H. Ackerman  n, J. Romanet n, E. Christiansen n, J. Niemuth n , C. Williams n, M. Breen n  ...

author keywords: Amphibian; Bufonidae; Immunogenetics; MHC; TLR; Transcriptomics
topics (OpenAlex): Amphibian and Reptile Biology; Aquaculture disease management and microbiota; Animal Behavior and Reproduction
TL;DR: Comparison transcriptomics is used to examine the diversity of toll-like receptors and major histocompatibility complex sequences across three individual Wyoming toads and finds reduced diversity at MHC genes compared to bufonid species with a similar history of bottleneck events. (via Semantic Scholar)
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15. Life on Land (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 29, 2022

2021 article

Hi‐C scaffolded short‐ and long‐read genome assemblies of the California sea lion are broadly consistent for syntenic inference across 45 million years of evolution

Peart, C. R., Williams, C., Pophaly, S. D., Neely, B. A., Gulland, F. M. D., Adams, D. J., … Wolf, J. B. W. (2021, June 8). Molecular Ecology Resources, Vol. 6.

By: C. Peart *, C. Williams n, S. Pophaly*, B. Neely *, F. Gulland *, D. Adams *, B. Ng *, W. Cheng * ...

author keywords: California sea lion (Zalophus californianus); cancer; Carnivora; chromatin interaction mapping; genome assembly; genome evolution; Hi-C
MeSH headings : Animals; Dogs; Ferrets; Genome; Sea Lions / genetics; Synteny; X Chromosome
topics (OpenAlex): Genomics and Phylogenetic Studies; Marine animal studies overview; Chromosomal and Genetic Variations
TL;DR: This study presents high-quality genomes of an emerging cancer model and highlights that even highly fragmented short-read assemblies scaffolded with Hi-C can yield reliable chromosome level scaffolds suitable for comparative genomic analyses. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2021

2017 journal article

Intracoronary allogeneic cardiosphere-derived stem cells are safe for use in dogs with dilated cardiomyopathy

Journal of Cellular and Molecular Medicine, 21(8), 1503–1512.

By: M. Hensley n, J. Tang n, K. Woodruff n, T. Defrancesco n , S. Tou n , C. Williams n, M. Breen n , K. Meurs n  ...

Contributors: M. Hensley n, J. Tang n, K. Woodruff n, T. Defrancesco n , S. Tou n , C. Williams n, M. Breen n , K. Meurs n , B. Keene  n, K. Cheng n

author keywords: cardiosphere-derived cells; dogs; dilated cardiomyopathy; stem cell therapy; allogeneic
MeSH headings : Animals; Biomarkers / metabolism; Cardiomyopathy, Dilated / diagnostic imaging; Cardiomyopathy, Dilated / immunology; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / therapy; Coronary Vessels / cytology; Coronary Vessels / immunology; Dogs; Echocardiography; Endoglin / genetics; Endoglin / immunology; Female; Gene Expression; Humans; Male; Myocardium / immunology; Myocardium / pathology; Proto-Oncogene Proteins c-kit / genetics; Proto-Oncogene Proteins c-kit / immunology; Spheroids, Cellular / cytology; Spheroids, Cellular / immunology; Spheroids, Cellular / transplantation; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / immunology; Thy-1 Antigens / genetics; Thy-1 Antigens / immunology; Transplantation, Homologous
topics (OpenAlex): Congenital heart defects research; Congenital Heart Disease Studies; Cardiovascular Conditions and Treatments
TL;DR: The safety and efficacy of allogeneic CDC in a large animal (canine) model of spontaneous DCM and Histology on dog hearts revealed no sign of immune rejection from the transplanted cells. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2017 article

Malignant canine mammary tumours: Preliminary genomic insights using oligonucleotide array comparative genomic hybridisation analysis

Santos, M., Dias-Pereira, P., Williams, C., Lopes, C., & Breen, M. (2017, March 28). The Veterinary Journal, Vol. 222, pp. 68–71.

By: M. Santos *, P. Dias-Pereira *, C. Williams n, C. Lopes * & M. Breen n 

Contributors: M. Santos *, P. Dias-Pereira *, C. Williams n, C. Lopes * & M. Breen n 

author keywords: Array comparative genomic hybridisation; Canine mammary tumours; Chromosome; Genetics
MeSH headings : Animals; Comparative Genomic Hybridization / veterinary; DNA Copy Number Variations; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Mammary Neoplasms, Animal / genetics; Mammary Neoplasms, Animal / pathology
topics (OpenAlex): Veterinary Oncology Research; Infectious Diseases and Mycology; Genomic variations and chromosomal abnormalities
TL;DR: High resolution oligonucleotide array comparative genomic hybridisation was performed to assess genome wide DNA copy number changes in 10 malignant canine mammary tumours from seven female dogs, including multiple tumours collected at one time from each of three female dogs. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 article

Canine prostate cancer cell line (Probasco) produces osteoblastic metastases in vivo

Simmons, J. K., Dirksen, W. P., Hildreth, B. E., Dorr, C., Williams, C., Thomas, R., … Rosol, T. J. (2014, July 7). The Prostate, Vol. 74, pp. 1251–1265.

By: J. Simmons*, W. Dirksen *, B. Hildreth *, C. Dorr n, C. Williams n, R. Thomas n, M. Breen n , R. Toribio *, T. Rosol *

Contributors: J. Simmons*, W. Dirksen *, B. Hildreth *, C. Dorr n, C. Williams n, R. Thomas n, M. Breen n , R. Toribio *, T. Rosol *

author keywords: prostate cancer; osteoblastic metastases; canine; dog
MeSH headings : Animals; Biomarkers, Tumor / genetics; Biomarkers, Tumor / metabolism; Bone Neoplasms / genetics; Bone Neoplasms / metabolism; Bone Neoplasms / secondary; Carcinoma / genetics; Carcinoma / metabolism; Carcinoma / secondary; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dogs; Male; Mice; Mice, Nude; Neoplasm Transplantation; Osteoblasts / metabolism; Osteoblasts / pathology; Prostatic Neoplasms / genetics; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology
topics (OpenAlex): Veterinary Oncology Research; Prostate Cancer Treatment and Research; Hedgehog Signaling Pathway Studies
TL;DR: This study established and characterized a novel canine prostate cancer cell line that will contribute to the understanding of prostate cancer pathogenesis. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 article

Definition of the Cattle Killer Cell Ig–like Receptor Gene Family: Comparison with Aurochs and Human Counterparts

Sanderson, N. D., Norman, P. J., Guethlein, L. A., Ellis, S. A., Williams, C., Breen, M., … Hammond, J. A. (2014, November 15). The Journal of Immunology, Vol. 193, pp. 6016–6030.

By: N. Sanderson *, P. Norman *, L. Guethlein *, S. Ellis*, C. Williams n, M. Breen n , S. Park*, D. Magee* ...

Contributors: N. Sanderson *, P. Norman *, L. Guethlein *, S. Ellis*, C. Williams n, M. Breen n , S. Park*, D. Magee* ...

MeSH headings : Animals; Cattle; Chromosome Mapping; Chromosomes, Mammalian; Cloning, Molecular; Evolution, Molecular; Gene Library; Genetic Loci; Genome; Haplotypes; Humans; Immunoglobulins / genetics; Molecular Sequence Data; Multigene Family; Phenotype; Phylogeny; Receptors, IgG / metabolism; Receptors, KIR / classification; Receptors, KIR / genetics; Receptors, KIR / metabolism; Receptors, Natural Killer Cell / metabolism; Sequence Analysis, DNA; Signal Transduction; Telomere
topics (OpenAlex): Immune Cell Function and Interaction; T-cell and B-cell Immunology; T-cell and Retrovirus Studies
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 article

CD40 ligand is necessary and sufficient to support primary diffuse large B-cell lymphoma cells in culture: a tool forin vitropreclinical studies with primary B-cell malignancies

Ito, D., Frantz, A. M., Williams, C., Thomas, R., Burnett, R. C., Avery, A. C., … Modiano, J. F. (2012, January 9). Leukemia & Lymphoma/Leukemia and Lymphoma, Vol. 53, pp. 1390–1398.

By: D. Ito *, A. Frantz *, C. Williams*, R. Thomas n, R. Burnett*, A. Avery *, M. Breen n , N. Mason *, T. O’Brien *, J. Modiano *

Contributors: D. Ito *, A. Frantz *, C. Williams*, R. Thomas n, R. Burnett*, A. Avery *, M. Breen n , N. Mason *, . T.D. O'Brien *, J. Modiano *

author keywords: Diffuse large B-cell lymphoma; CD40L; primary cell culture; canine model; cytotoxicity assay
MeSH headings : Animals; CD40 Ligand / genetics; CD40 Ligand / metabolism; CD40 Ligand / pharmacology; Cell Culture Techniques / methods; Cell Proliferation / drug effects; Cell Survival / drug effects; Coculture Techniques; Dogs; Dose-Response Relationship, Drug; Feeder Cells / metabolism; Gene Expression Profiling; Humans; Lymphoma, Large B-Cell, Diffuse / genetics; Lymphoma, Large B-Cell, Diffuse / metabolism; Lymphoma, Large B-Cell, Diffuse / pathology; Oligonucleotide Array Sequence Analysis; Recombinant Proteins / pharmacology; Tumor Cells, Cultured
topics (OpenAlex): Veterinary Oncology Research; Infectious Diseases and Mycology; Virus-based gene therapy research
TL;DR: This work used primary canine diffuse large B-cell lymphoma to establish a culture system that reliably supports the growth of these cells in vitro and illustrates the utility of the feeder cell-free culture system for comparable assessment of cytotoxicity using dog and human B- cell malignancies. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 article

Calf birth weight, gestation length, calving ease, and neonatal calf mortality in Holstein, Jersey, and crossbred cows in a pasture system

Dhakal, K., Maltecca, C., Cassady, J. P., Baloche, G., Williams, C. M., & Washburn, S. P. (2012, October 23). Journal of Dairy Science, Vol. 96, pp. 690–698.

By: K. Dhakal n, C. Maltecca n , J. Cassady n, G. Baloche, C. Williams n & S. Washburn n

Contributors: K. Dhakal n, C. Maltecca n , J. Cassady n, G. Baloche, C. Williams n & S. Washburn n

author keywords: crossbreeding; genetic group; Holstein; Jersey
MeSH headings : Animals; Animals, Newborn / physiology; Birth Weight / genetics; Birth Weight / physiology; Breeding; Cattle / genetics; Cattle / physiology; Delivery, Obstetric; Female; Gestational Age; Pregnancy; Pregnancy, Animal / genetics; Pregnancy, Animal / physiology; Stillbirth / veterinary
topics (OpenAlex): Genetic and phenotypic traits in livestock; Reproductive Physiology in Livestock; Animal health and immunology
TL;DR: Maternal heterosis in crossbred primiparous dams was associated with reduced calf mortality and Genetic groups were replaced by linear regression using percentage of HH genes as coefficients on the above models and included as covariates to determine various genetic effects. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2011 article

Development of a brain metastatic canine prostate cancer cell line

Thudi, N. K., Shu, S. T., Martin, C. K., Lanigan, L. G., Nadella, M. V. P., Bokhoven, A. V., … Rosol, T. J. (2011, February 14). The Prostate, Vol. 71, pp. 1251–1263.

By: N. Thudi*, S. Shu*, C. Martin *, L. Lanigan *, M. Nadella*, A. Bokhoven *, J. Werbeck*, J. Simmons* ...

Contributors: N. Thudi*, S. Shu*, C. Martin *, L. Lanigan *, M. Nadella*, A. Van Bokhoven *, J. Werbeck*, J. Simmons* ...

author keywords: prostate cancer; brain metastasis; spinal cord metastasis; dog; canine; bone metastasis
MeSH headings : Adrenal Gland Neoplasms / epidemiology; Adrenal Gland Neoplasms / secondary; Animals; Antineoplastic Agents / pharmacology; Bone Neoplasms / epidemiology; Bone Neoplasms / secondary; Boronic Acids / pharmacology; Bortezomib; Brain Neoplasms / epidemiology; Brain Neoplasms / metabolism; Brain Neoplasms / pathology; Brain Neoplasms / secondary; Carcinogenicity Tests; Carcinoma / epidemiology; Carcinoma / metabolism; Carcinoma / pathology; Carcinoma / secondary; Cell Division; Cell Line, Tumor / drug effects; Cell Line, Tumor / pathology; Dogs; Immunohistochemistry; Incidence; Injections, Subcutaneous; Keratin-18 / metabolism; Keratin-7 / metabolism; Keratin-8 / metabolism; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Connective Tissue / secondary; Parathyroid Hormone-Related Protein / metabolism; Phenylbutyrates / antagonists & inhibitors; Prostatic Neoplasms / pathology; Pyrazines / pharmacology; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord Neoplasms / epidemiology; Spinal Cord Neoplasms / secondary; Subcutaneous Tissue; Transplantation, Heterologous
topics (OpenAlex): Prostate Cancer Treatment and Research; Cancer, Stress, Anesthesia, and Immune Response; Cancer Cells and Metastasis
TL;DR: The goal of the study was to establish and characterize a new prostate cancer line derived from a dog with spontaneous prostate cancer. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2010 article

BCR‐ABL translocation in a dog with chronic monocytic leukemia

Cardona, J. A. C., Milner, R., Alleman, A. R., Williams, C., Vernau, W., Breen, M., & Tompkins, M. (2010, December 10). Veterinary Clinical Pathology, Vol. 40, pp. 40–47.

By: J. Cardona*, R. Milner *, A. Alleman*, C. Williams n, W. Vernau*, M. Breen n , M. Tompkins n

Contributors: J. Cruz Cardona*, R. Milner *, A. Alleman*, C. Williams n, W. Vernau*, M. Breen n , M. Tompkins n

author keywords: FISH; flow cytometry; monocytosis; myeloproliferative disorder
MeSH headings : Animals; Bone Marrow Cells / pathology; Dog Diseases / diagnosis; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Flow Cytometry / veterinary; Leukemia, Myeloid / diagnosis; Leukemia, Myeloid / genetics; Leukemia, Myeloid / pathology; Leukemia, Myeloid / veterinary; Translocation, Genetic / genetics
topics (OpenAlex): Chronic Myeloid Leukemia Treatments; Hematopoietic Stem Cell Transplantation; Virus-based gene therapy research
TL;DR: Clinical and laboratory findings and the protracted course supported a diagnosis of chronic monocytic leukemia (CMoL), the first case of CMoL with a BCR-ABL chromosomal abnormalitiy described in dogs, and may have clinical implications for treatment of dogs with chronic leukemias associated with particular genetic mutations. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

journal article

A comprehensive genomic history of extinct and living elephants

Palkopoulou, E., Lipson, M., Mallick, S., Nielsen, S., Rohland, N., Baleka, S., … Meller, H. Proceedings of the National Academy of Sciences of the United States of America, 115(11), E2566–2574.

By: E. Palkopoulou, M. Lipson, S. Mallick, S. Nielsen, N. Rohland, S. Baleka, E. Karpinski, A. Ivancevici ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers

Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Kim, J. H. PLoS Genetics, 11(2).

By: N. Tonomura, I. Elvers, R. Thomas, K. Megquier, J. Turner-Maier, C. Howald, A. Sarver, R. Swofford ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

The genome of the green anole lizard and a comparative analysis with birds and mammals

Alfoldi, J., Di Palma, F., Grabherr, M., Williams, C., Kong, L. S., Mauceli, E., … Moreno, R. G. Nature, 477(7366), 587–591.

By: J. Alfoldi, F. Di Palma, M. Grabherr, C. Williams, L. Kong, E. Mauceli, P. Russell, C. Lowe ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Three crocodilian genomes reveal ancestral patterns of evolution among archosaurs

Green, R. E., Braun, E. L., Armstrong, J., Earl, D., Nguyen, N., Hickey, G., … Hubley, R. M. Science, 346(6215), 1335-.

By: R. Green, E. Braun, J. Armstrong, D. Earl, N. Nguyen, G. Hickey, M. Vandewege, J. St John ...

Source: NC State University Libraries
Added: August 6, 2018

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