@article{delaney_robveille_maggi_lashnits_kingston_liedig_murray_fallon_breitschwerdt_2024, title={<i>Bartonella</i> species bacteremia in association with adult psychosis}, volume={15}, ISSN={["1664-0640"]}, url={http://dx.doi.org/10.3389/fpsyt.2024.1388442}, DOI={10.3389/fpsyt.2024.1388442}, abstractNote={Introduction The potential role of pathogens, particularly vector-transmitted infectious agents, as a cause of psychosis has not been intensively investigated. We have reported a potential link between Bartonella spp. bacteremia and neuropsychiatric symptoms, including pediatric acute onset neuropsychiatric syndrome and schizophrenia. The purpose of this study was to further assess whether Bartonella spp. exposure or infection are associated with psychosis. Methods In a blinded manner, we assessed the presence of anti- Bartonella antibodies by indirect immunofluorescence assays (IFA), and infection by amplification of bacterial DNA from blood by quantitative polymerase chain reaction (qPCR), digital PCR (dPCR), and droplet digital PCR (ddPCR) in 116 participants. Participants were categorized into one of five groups: 1) controls unaffected by psychosis ( n = 29); 2) prodromal participants ( n = 16); 3) children or adolescents with psychosis ( n = 7); 4) adults with psychosis ( n = 44); and 5) relatives of a participant with psychosis ( n = 20). Results There was no significant difference in Bartonella spp. IFA seroreactivity between adults with psychosis and adult controls unaffected by psychosis. There was a higher proportion of adults with psychosis who had Bartonella spp. DNA in the bloodstream (43.2%) compared to adult controls unaffected by psychosis (14.3%, p = 0.021). The Bartonella species was determined for 18 of the 31 bacteremic participants, including infection or co-infection with Bartonella henselae (11/18), Bartonella vinsonii subsp. b erkhoffii (6/18), Bartonella quintana (2/18), Bartonella alsatica (1/18), and Bartonella rochalimae (1/18). Discussion In conjunction with other recent research, the results of this study provide justification for a large national or international multi-center study to determine if Bartonella spp. bacteremia is more prevalent in adults with psychosis compared to adults unaffected by psychosis. Expanding the investigation to include a range of vector-borne and other microbial infections with potential CNS effects would enhance knowledge on the relationship between psychosis and infection.}, journal={FRONTIERS IN PSYCHIATRY}, author={Delaney, Shannon and Robveille, Cynthia and Maggi, Ricardo G. and Lashnits, Erin and Kingston, Emily and Liedig, Chance and Murray, Lilly and Fallon, Brian A. and Breitschwerdt, Edward B.}, year={2024}, month={Jun} }
 @article{robveille_cuvelier_2024, title={What is your diagnosis? Fine-needle aspirate from a neck lesion in a dog}, volume={9}, ISSN={["1939-165X"]}, url={https://doi.org/10.1111/vcp.13389}, DOI={10.1111/vcp.13389}, journal={VETERINARY CLINICAL PATHOLOGY}, author={Robveille, Cynthia and Cuvelier, Marie}, year={2024}, month={Sep} }
 @article{gish_robveille_gicquel_allorge_gault_gaulier_2022, title={Analytical documentation of an Arabian horse fatality related to Oenanthe crocata poisoning}, volume={210}, url={http://dx.doi.org/10.1016/j.toxicon.2022.02.009}, DOI={10.1016/j.toxicon.2022.02.009}, abstractNote={Analytical detection of Oenanthe crocata toxins in biological samples is challenging because of their instability, the lack of commercially available standards and the exceptionally low detection of these molecules using mass spectrometry. This work aims to report the used analytical methods that allowed identification of the main plant toxins in biological samples from an equid (an Arabian horse) fatality related to hemlock water dropwort (Oenanthe crocata Linnaeus) intake. Using both LC-DAD and LC-HRMS methods allowed identification (i) of oenanthotoxin in roots found on the site, root fragments found in the stomach, stomach content, kidney, and liver, and (ii) of the hydrogenated metabolite of oenanthotoxin (2,3-dihydro-oenanthotoxin) in roots found on the site, root fragments found in the stomach, stomach content, kidney, liver and spleen. Reported analytical data about Oenanthe crocata toxins can be useful for identification of the ingested plant and for supporting a poisoning diagnosis in such cases.}, journal={Toxicon}, publisher={Elsevier BV}, author={Gish, Alexandr and Robveille, Cynthia and Gicquel, Thomas and Allorge, Delphine and Gault, Gilbert and Gaulier, Jean-Michel}, year={2022}, month={Apr}, pages={39–43} }
 @article{robveille_kim_stayt_sharp_langner_2022, title={Disseminated T-cell lymphoma with non-epitheliotropic cutaneous involvement in a cat with erythematous patches and regenerative anemia}, volume={10}, ISSN={["1943-4936"]}, url={https://doi.org/10.1177/10406387221133543}, DOI={10.1177/10406387221133543}, abstractNote={ A 14-y-old, castrated male, diabetic, domestic longhaired cat was presented for investigation of anemia. General examination revealed widespread cutaneous erythematous macules and patches. Hematology and bone marrow aspiration revealed severe regenerative anemia and marked erythroid hyperplasia, respectively. Low numbers of intermediate-to-large, atypical lymphocytes were observed in the blood smear and bone marrow aspirates. Various imaging modalities demonstrated a diffuse pulmonary bronchial pattern, multifocal mural thickening of the urinary bladder, splenomegaly, and mild tri-cavitary effusion. Skin biopsies and cytologic examination of the pleural effusion demonstrated round-cell neoplasia consistent with lymphoma. Autopsy confirmed disseminated T-cell lymphoma, mostly affecting the urinary bladder, stomach, lymph nodes, and interscapular subcutis and muscles. Angiocentrism and nerve infiltration were present. The cutaneous erythematous patches, characterized by perivascular neoplastic lymphocytic infiltrates and angiodestruction, were a manifestation of the disseminated lymphoma in this cat, similar to the lesions reported in humans affected by angioimmunoblastic T-cell lymphoma. }, journal={JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION}, author={Robveille, Cynthia and Kim, Mark W. and Stayt, Jason and Sharp, Claire R. and Langner, Kathrin F. A.}, year={2022}, month={Oct} }
 @article{robveille_cullen_2022, title={Hepatocellular carcinomas in captive prosimians}, ISSN={["1544-2217"]}, url={https://doi.org/10.1177/03009858221114471}, DOI={10.1177/03009858221114471}, abstractNote={ We performed a retrospective examination of spontaneous hepatocellular carcinomas (HCCs) (primary and metastatic tumors) in 14 captive prosimians brought to the Veterinary Medical Diagnostic Laboratory in North Carolina State University over a period of 11 years (2003 to 2014) to characterize the tumors. These animals are endangered primates; a better understanding of the main fatal neoplasms is crucial. In addition to the histologic evaluation, an immunohistochemical study was also performed, using a hepatocyte marker (hepatocyte paraffin 1 [HepPar-1]) and 2 cholangiocyte markers (keratin 7 [K7] and keratin 19 [K19]), in an attempt to identify a specific profile for HCCs with metastatic behavior. Six of the 14 HCCs had pulmonary metastases. The most frequent histopathological findings were a trabecular pattern (14/14, 100%), presence of multinucleated cells (12/14, 85.7%), and foci of extramedullary hematopoiesis (9/14, 64.3%). The mitotic count was significantly higher in the metastatic HCCs ( P < .05). HepPar-1 was detected in all primary and metastatic HCCs, with a strong intensity of staining. Labeling for K7 and K19 was positive in 12 HCCs (85.7%) and 1 HCC (7.1%), respectively. Contrary to the less aggressive HCCs, most of the metastatic HCCs (5/6) expressed K7 in more than 15% of cells. The percentage of K7-positive neoplastic hepatocytes was significantly higher in metastatic HCCs. This study suggests that K7 might be a prognostically relevant marker in HCCs of captive prosimians. }, journal={VETERINARY PATHOLOGY}, author={Robveille, Cynthia and Cullen, John M.}, year={2022}, month={Jul} }
 @article{bunn_robveille_irwin_langner_2021, title={A neurological presentation caused by brain metastases in a dog with interventricular septal hemangiosarcoma}, volume={99}, url={http://dx.doi.org/10.1111/avj.13050}, DOI={10.1111/avj.13050}, abstractNote={Background Brain metastases are well known for disseminated hemangiosarcoma involving the right atrium/auricle. Case report An 8‐year‐old male Australian Shepherd Dog presented with a 3‐day history of circling to the left. A neurological examination revealed obtunded mentation, right hemi‐inattention, bilateral strabismus towards the left side and absent physiological nystagmus. In addition, the dog had muffled heart sounds on auscultation and exercise‐induced weakness. Laboratory findings included hypercoagulability and marked elevation in the C‐reactive protein concentration. Electrocardiography detected a sinus rhythm with right bundle‐branch block and ventricular bigeminy. Echocardiography revealed an extensive interventricular septal mass. Due to the grave prognosis, the owners elected for euthanasia, and a complete necropsy was performed. The main pathological findings were an interventricular septal and left ventricular hemangiosarcoma, with metastases in the brain, lungs, spleen and adrenal glands. No evidence of tumour infiltration was found in the right atrium. Conclusion To the authors' knowledge, this is the first report of neurological signs due to confirmed brain metastases in a dog with interventricular septal hemangiosarcoma. Although the right atrium is the main location for cardiac hemangiosarcoma, the interventricular septum should be evaluated in all cases.}, number={4}, journal={Australian Veterinary Journal}, publisher={Wiley}, author={Bunn, TA and Robveille, C and Irwin, PJ and Langner, KFA}, year={2021}, month={Apr}, pages={119–123} }
 @article{robveille_smart_boyd_2020, title={Obstructive shock caused by right atrial thrombosis secondary to malignant pheochromocytoma in a dog}, volume={98}, url={http://dx.doi.org/10.1111/avj.12992}, DOI={10.1111/avj.12992}, abstractNote={Obstructive shock can be caused by any lesion leading to extraluminal compression or intraluminal occlusion of the cardiac chambers or major vessels.A 12-year-old, male castrated, Border Collie cross dog presented to a veterinary teaching hospital for collapse. A physical examination revealed severe vasoconstrictive shock and abdominal distension. Abnormalities on blood tests were consistent with systemic hypoperfusion. Cardiac underfilling, hepatomegaly with distended vasculature and ascites were identified by focused ultrasonography, raising suspicion of obstructive shock. This was supported by the radiographic findings of microcardia and a distended caudal vena cava (CVC). There was transient response to fluid therapy for blood volume expansion. Repeat focused ultrasonography during rapid intravenous fluid administration identified a right intra-atrial mass, assessed as likely to be causing obstruction of venous return. The dog was humanely euthanased given the guarded prognosis. At postmortem evaluation, a malignant pheochromocytoma in the left adrenal gland with tumour thrombus extending to the tricuspid valve through the CVC was found. The extensive thrombus caused the obstructive shock in this case. Metastasis in a peripheral lymph node and neoplastic emboli in the heart and lungs were also visible at the histopathological evaluation.To the best of authors' knowledge, this is the first report of severe obstructive shock secondary to extension of caval tumour thrombus into the right atrium in a dog with malignant pheochromocytoma. Tumour thrombus from a malignant pheochromocytoma should be included as a differential diagnosis of obstructive shock, with or without a visible right intra-atrial mass, in dogs. Serial focused ultrasonography during intravenous fluid administration can aid diagnosis.}, number={9}, journal={Australian Veterinary Journal}, publisher={Wiley}, author={Robveille, C and Smart, L and Boyd, CJ}, year={2020}, month={Sep}, pages={462–466} }
 @article{thrombocytosis and central nervous system involvement in a case of canine acute megakaryoblastic leukemia_2018, volume={47}, url={http://dx.doi.org/10.1111/vcp.12642}, DOI={10.1111/vcp.12642}, abstractNote={Abstract This case report presents a 14‐month‐old female Poodle mix with acute megakaryoblastic leukemia based on a marked thrombocytosis, abnormal platelet morphology, circulating dwarf megakaryocytes, and blast cells in the blood. Bone marrow abnormalities included dysmegakaryopoiesis dygranulopoiesis, and an increased number of blast cells was observed in the blood. Extensive leukemic involvement was also found in the liver, spleen, lymph nodes, lungs, kidneys, and brain. The cytopathologic features of the abnormal circulating cells were highly suggestive of being megakaryocytic in origin, which was supported by negative myeloperoxidase staining and positive von Willebrand factor staining on immunocytochemistry (ICC). The neoplastic cells were also CD61 positive and had variable von Willebrand factor expression on ICC. Although there were only 25% blast cells in the bone marrow, which theoretically supported myelodysplastic syndrome, the hypothesis that this case represented acute myeloid leukemia of megakaryoblastic origin was confirmed by the continuous increase in circulating blast cell numbers during follow‐up visits and the extensive leukemic involvement of parenchymal organs.}, number={3}, journal={Veterinary Clinical Pathology}, publisher={Wiley}, year={2018}, month={Sep}, pages={363–367} }
 @article{long-term neurologic and cardiac correction by intrathecal gene therapy in pompe disease_2017, volume={5}, url={http://dx.doi.org/10.1186/s40478-017-0464-2}, DOI={10.1186/s40478-017-0464-2}, abstractNote={Pompe disease is a lysosomal storage disorder caused by acid-α-glucosidase (GAA) deficiency, leading to glycogen storage. The disease manifests as a fatal cardiomyopathy in infantile form. Enzyme replacement therapy (ERT) has recently prolonged the lifespan of these patients, revealing a new natural history. The neurologic phenotype and the persistence of selective muscular weakness in some patients could be attributed to the central nervous system (CNS) storage uncorrected by ERT. GAA-KO 6neo/6neo mice were treated with a single intrathecal administration of adeno-associated recombinant vector (AAV) mediated gene transfer of human GAA at 1 month and their neurologic, neuromuscular, and cardiac function was assessed for 1 year. We demonstrate a significant functional neurologic correction in treated animals from 4 months onward, a neuromuscular improvement from 9 months onward, and a correction of the hypertrophic cardiomyopathy at 12 months. The regions most affected by the disease i.e. the brainstem, spinal cord, and the left cardiac ventricular wall all show enzymatic, biochemical and histological correction. Muscle glycogen storage is not affected by the treatment, thus suggesting that the restoration of muscle functionality is directly related to the CNS correction. This unprecedented global and long-term CNS and cardiac cure offer new perspectives for the management of patients.}, number={1}, journal={Acta Neuropathologica Communications}, publisher={Springer Science and Business Media LLC}, year={2017}, month={Dec} }
 @article{robveille_albaric_gaide_abadie_2015, title={Disseminated mycobacteriosis manifesting as paraplegia in two Parma wallabies (Macropus parma) naturally exposed to Mycobacterium avium}, volume={27}, url={http://dx.doi.org/10.1177/1040638715608897}, DOI={10.1177/1040638715608897}, abstractNote={Two captive female Parma wallabies (Macropus parma) died after a history of flaccid paraplegia. On postmortem examination, granulomatous and suppurative osteomyelitis involving the left ischium and the lumbosacral region, with meningeal extension at the cauda equina, and caseonecrotic mastitis were the most significant changes. Multiple small nodules in the liver and spleen, and an enlargement of some lymph nodes with central caseous necrosis were also observed. Microscopically, a disseminated granulomatous inflammation with numerous multinucleate giant cells was seen. Numerous acid-fast bacilli were detected in macrophages, in multinucleated giant cells, and free in the central necrosis and suppurative exudate. After culture, polymerase chain reaction assays were carried out to detect the 65-kDa heat shock protein (Hsp65) and insertion sequences (IS)1245 and IS900. The causative agent was identified as Mycobacterium avium subsp. avium.}, number={6}, journal={Journal of Veterinary Diagnostic Investigation}, publisher={SAGE Publications}, author={Robveille, Cynthia and Albaric, Olivier and Gaide, Nicolas and Abadie, Jérome}, year={2015}, month={Nov}, pages={767–771} }
 @article{gaide_pelandakis_robveille_albaric_jouvion_souchon_risler_abadie_2015, title={Necrotizing Meningoencephalitis in a Captive Black and White Ruffed Lemur (Varecia variegata variegata) Caused by Acanthamoeba T4 Genotype}, volume={153}, url={http://dx.doi.org/10.1016/j.jcpa.2015.07.005}, DOI={10.1016/j.jcpa.2015.07.005}, abstractNote={A mature male, black and white ruffed lemur (Varecia variegata variegata) died in a zoological garden after a 4-day history of lethargy and non-responsive convulsions. Necropsy and histopathological examinations revealed acute necrotizing and haemorrhagic meningoencephalitis with intralesional amoebas confirmed by immunohistochemistry. Acanthamoeba T4 genotype was identified as the causative agent of the brain lesion, based on amplification and sequencing of 18S ribosomal RNA genes. The presence of free-living amoebas in water and mud from the lemur's environment was investigated by morphological and molecular analyses. The two predominant genera, representing 80% of isolated amoebas, were Naegleria spp. and Acanthamoeba spp. All Acanthamoeba isolates belonged to the T4 genotype. To the author's knowledge, this is the first report of a meningoencephalitis due to Acanthamoeba T4 genotype in Lemuridae with concurrent analysis of pathological tissues and environment.}, number={4}, journal={Journal of Comparative Pathology}, publisher={Elsevier BV}, author={Gaide, N. and Pelandakis, M. and Robveille, C. and Albaric, O. and Jouvion, G. and Souchon, M. and Risler, A. and Abadie, J.}, year={2015}, month={Nov}, pages={231–235} }