@misc{peng_chen_spicer_jiang_2021, title={Acoustics at the nanoscale (nanoacoustics): A comprehensive literature review. Part II: Nanoacoustics for biomedical imaging and therapy}, volume={332}, ISSN={["1873-3069"]}, DOI={10.1016/j.sna.2021.112925}, abstractNote={In the past decade, acoustics at the nanoscale (i.e., nanoacoustics) has evolved rapidly with continuous and substantial expansion of capabilities and refinement of techniques. Motivated by research innovations in the last decade, for the first time, recent advancements of acoustics-associated nanomaterials/nanostructures and nanodevices for different applications are outlined in this comprehensive review, which is written in two parts. As part II of this two-part review, this paper concentrates on nanoacoustics in biomedical imaging and therapy applications, including molecular ultrasound imaging, photoacoustic imaging, ultrasound-mediated drug delivery and therapy, and photoacoustic drug delivery and therapy. Firstly, the recent developments of nanosized ultrasound and photoacoustic contrast agents as well as their various imaging applications are examined. Secondly, different types of nanomaterials/nanostructures as nanocarriers for ultrasound and photoacoustic therapies are discussed. Finally, a discussion of challenges and future research directions are provided for nanoacoustics in medical imaging and therapy.}, journal={SENSORS AND ACTUATORS A-PHYSICAL}, author={Peng, Chang and Chen, Mengyue and Spicer, James B. and Jiang, Xiaoning}, year={2021}, month={Dec} }
 @article{peng_chen_wang_shen_jiang_2021, title={Broadband Piezoelectric Transducers for Under-Display Ultrasonic Fingerprint Sensing Applications}, volume={68}, ISSN={["1557-9948"]}, DOI={10.1109/TIE.2020.2984977}, abstractNote={Smartphones today have attracted a continuous trend of pursuing narrow-bezel and full-screen displays. To allow for a more user-friendly front side fingerprint recognition in full-screen displays, it is crucial to develop an under-display type of fingerprint sensor. Among fingerprint sensing techniques, ultrasonic fingerprint sensing has been proved to be able to provide more distinctive features and give a high resistance to spoof attacks. However, until now no study about under-display ultrasonic fingerprint sensing has been reported. In this article, for the first time, multilayer under-display ultrasonic fingerprint sensor structure using various active materials/structures were theoretically designed and compared. Based on the theoretical analysis results, a lead zirconate titanate (PZT)-5A-based multilayer under-display ultrasonic fingerprint sensor with a resonant frequency of 20 MHz, and a −6-dB fractional bandwidth of more than 70% was fabricated to meet the requirements of resolution and sensitivity for the under-display ultrasonic fingerprint imaging applications. The prototyped sensor was characterized, and the fingerprint recognition capability was tested using a custom-made fingerprint-mimicking phantom. The phantom images were acquired based on the pulse-echo imaging method. With the 1 μJ impulse driving signal, the sensor was manipulated to image a 2.0 mm × 1.0 mm section of fingerprint-mimicking phantom by mechanical scanning, obtaining an electronic image with 500 × 500 DPI. The fingerprint-mimicking phantom imaging results suggest that the 20 MHz broadband PZT-based multilayer structure holds great potential for under-display ultrasonic fingerprint sensor applications.}, number={5}, journal={IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS}, author={Peng, Chang and Chen, Mengyue and Wang, Hongchao and Shen, Jian and Jiang, Xiaoning}, year={2021}, month={May}, pages={4426–4434} }
 @article{meng_zhang_lin_liu_zhou_ge_su_peng_zhang_2021, title={Effects of particle size of dielectric fillers on the output performance of piezoelectric and triboelectric nanogenerators}, ISSN={["2227-8508"]}, DOI={10.1007/s40145-021-0482-1}, abstractNote={Abstract}, journal={JOURNAL OF ADVANCED CERAMICS}, author={Meng, Xiao and Zhang, Zhuo and Lin, Dabin and Liu, Weiguo and Zhou, Shun and Ge, Shaobo and Su, Yongming and Peng, Chang and Zhang, Lin}, year={2021}, month={May} }
 @article{peng_moghaddam_2021, title={Experimental Evaluation and Kinetic Analysis of Direct-Contact Ultrasonic Fabric Drying Process}, volume={13}, ISSN={["1948-5093"]}, DOI={10.1115/1.4047566}, abstractNote={Abstract}, number={2}, journal={JOURNAL OF THERMAL SCIENCE AND ENGINEERING APPLICATIONS}, author={Peng, Chang and Moghaddam, Saeed}, year={2021}, month={Apr} }
 @article{zhang_wu_goel_kim_peng_kim_dayton_gao_jiang_2021, title={Magneto-sonothrombolysis with combination of magnetic microbubbles and nanodroplets}, volume={116}, ISSN={["1874-9968"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-85107639068&partnerID=MN8TOARS}, DOI={10.1016/j.ultras.2021.106487}, abstractNote={This paper reports a novel technique using the rotational magnetic field oscillation and low-intensity sub-megahertz ultrasound stimulation of magnetic microbubbles (MMBs) to promote the nanodroplets (NDs) phase transition and improve the permeation of NDs into the blood clot fibrin network to enhance the sonothrombolysis efficiency. In this study, the influence of different treatment methods with a combination of MMBs and NDs on the thrombolysis rate of both unretracted and retracted clots were investigated, including the stable and inertial cavitation, tPA effects, MMBs/NDs concentration ratio, sonication factors (input voltage, duty cycle) and rotational magnetic field factors (flux density, frequency). We demonstrated that tPA-mediated magneto-sonothrombolysis in combining NDs with MMBs could significantly enhance in vitro lysis of both unretracted clots (85 ± 8.3%) and retracted clots (57 ± 6.5%) in a flow model with 30 min treatment. The results showed that the combination of MMBs and NDs substantially improves in vitro lysis of blood clots with an unprecedented lysis rate.}, journal={ULTRASONICS}, author={Zhang, Bohua and Wu, Huaiyu and Goel, Leela and Kim, Howuk and Peng, Chang and Kim, Jinwook and Dayton, Paul A. and Gao, Yu and Jiang, Xiaoning}, year={2021}, month={Sep} }
 @article{peng_chen_sim_zhu_jiang_2021, title={Noninvasive and Nonocclusive Blood Pressure Monitoring via a Flexible Piezo-Composite Ultrasonic Sensor}, volume={21}, ISSN={["1558-1748"]}, DOI={10.1109/JSEN.2020.3021923}, abstractNote={Continuous blood pressure monitoring in everyday life is important and necessary to detect and control high blood pressure in advance. While the existing blood pressure monitoring techniques are well suited for applications in current clinical settings, they are inadequate for next-generation wearable long-term monitoring of blood pressure on a daily basis. In this study, a flexible piezo-composite ultrasonic sensor was reported, for the first time, for continuous blood pressure measurement through ultrasonic motion tracking of blood vessel wall. A flexible piezo-composite ultrasonic sensor was designed and fabricated with a layer of PZT-5A/ polydimethylsiloxane (PDMS) anisotropic 1–3 composite and silver nanowire based stretchable electrodes. The material properties and dimensions of the sensor were determined according to the volume fraction of PZT-5A and the material properties of PZT-5A and PDMS. The experimental results illustrated that the flexible sensor possessed adequate bandwidth and sensitivity for blood pressure monitoring. Continuous blood pressure measurement was successfully conducted with the ulnar artery on a volunteer’s right arm. Compared with the measurement results using a clinical ultrasound probe and a commercial upper arm blood monitor, the results obtained in this study demonstrated the capability of the proposed flexible sensor to continuously monitor blood pressure waveforms during cardiac cycles. The flexible sensor provides a promising solution for noninvasive, nonocclusive and calibration-free blood pressure monitoring. It has great potential to be integrated into a wearable ultrasonic healthcare sensing system for blood pressure and flow monitoring.}, number={3}, journal={IEEE SENSORS JOURNAL}, author={Peng, Chang and Chen, Mengyue and Sim, Hun Ki and Zhu, Yong and Jiang, Xiaoning}, year={2021}, month={Feb}, pages={2642–2650} }
 @article{cai_peng_lu_prieto_rosenbaum_stringer_jiang_2021, title={Performance Enhanced Ultrasound Probe Tracking With a Hemispherical Marker Rigid Body}, volume={68}, ISSN={["1525-8955"]}, DOI={10.1109/TUFFC.2021.3058145}, abstractNote={Among tracking techniques applied in the 3-D freehand ultrasound (US), the camera-based tracking method is relatively mature and reliable. However, constrained by manufactured marker rigid bodies, the US probe is usually limited to operate within a narrow rotational range before occlusion issues affect accurate and robust tracking performance. Thus, this study proposed a hemispherical marker rigid body to hold passive noncoplanar markers so that the markers could be identified by the camera, mitigating self-occlusion. The enlarged rotational range provides greater freedom for sonographers while performing examinations. The single-axis rotational and translational tracking performances of the system, equipped with the newly designed marker rigid body, were investigated and evaluated. Tracking with the designed marker rigid body achieved high tracking accuracy with 0.57° for the single-axis rotation and 0.01 mm for the single-axis translation for sensor distance between 1.5 and 2 m. In addition to maintaining high accuracy, the system also possessed an enhanced ability to capture over 99.76% of the motion data in the experiments. The results demonstrated that with the designed marker rigid body, the missing data were remarkably reduced from over 15% to less than 0.5%, which enables interpolation in the data postprocessing. An imaging test was further conducted, and the volume reconstruction of a four-month fetal phantom was demonstrated using the motion data obtained from the tracking system.}, number={6}, journal={IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL}, author={Cai, Qianqian and Peng, Chang and Lu, Jian-Yu and Prieto, Juan C. and Rosenbaum, Alan J. and Stringer, Jeffrey S. A. and Jiang, Xiaoning}, year={2021}, month={Jun}, pages={2155–2163} }
 @misc{peng_wu_kim_dai_jiang_2021, title={Recent Advances in Transducers for Intravascular Ultrasound (IVUS) Imaging}, volume={21}, ISSN={["1424-8220"]}, DOI={10.3390/s21103540}, abstractNote={As a well-known medical imaging methodology, intravascular ultrasound (IVUS) imaging plays a critical role in diagnosis, treatment guidance and post-treatment assessment of coronary artery diseases. By cannulating a miniature ultrasound transducer mounted catheter into an artery, the vessel lumen opening, vessel wall morphology and other associated blood and vessel properties can be precisely assessed in IVUS imaging. Ultrasound transducer, as the key component of an IVUS system, is critical in determining the IVUS imaging performance. In recent years, a wide range of achievements in ultrasound transducers have been reported for IVUS imaging applications. Herein, a comprehensive review is given on recent advances in ultrasound transducers for IVUS imaging. Firstly, a fundamental understanding of IVUS imaging principle, evaluation parameters and IVUS catheter are summarized. Secondly, three different types of ultrasound transducers (piezoelectric ultrasound transducer, piezoelectric micromachined ultrasound transducer and capacitive micromachined ultrasound transducer) for IVUS imaging are presented. Particularly, the recent advances in piezoelectric ultrasound transducer for IVUS imaging are extensively examined according to their different working mechanisms, configurations and materials adopted. Thirdly, IVUS-based multimodality intravascular imaging of atherosclerotic plaque is discussed. Finally, summary and perspectives on the future studies are highlighted for IVUS imaging applications.}, number={10}, journal={SENSORS}, author={Peng, Chang and Wu, Huaiyu and Kim, Seungsoo and Dai, Xuming and Jiang, Xiaoning}, year={2021}, month={May} }
 @article{peng_zhang_wu_dayton_xu_jiang_2021, title={Ultrasound Imaging-Guided Microbubble-Mediated Catheter-Directed Sonothrombolysis: An In-Vitro Study}, ISSN={["2378-377X"]}, DOI={10.1109/NMDC50713.2021.9677506}, abstractNote={Summary form only given, as follows. The complete presentation was not made available for publication as part of the conference proceedings. Deep vein thrombosis (DVT) is the formation of a blood clot in a deep vein, usually in the lower leg or thigh. The most serious complication of DVT is pulmonary embolism, which happens when part of the blood clot breaks off and travels through the bloodstream to the lungs, suddenly blocking blood flow. While using clot dissolving drugs is the standard treatment for DVT, thrombolytic drugs illustrate low thrombolysis efficiency and risk of bleeding side effects. Catheter-directed thrombolysis that uses a catheter to guide medication or a medical device to the site of a blood clot to dissolve the blockage, has become one of the most widely available and effective treatments for DVT. In this study, we combine a catheter-delivered forward-looking ultrasound transducer with microbubbles for microbubble-mediated catheter-directed sonothrombolysis, in order to reduce treatment time and increase treatment efficacy. A 600 kHz stack ultrasound transducer is developed and integrated into one lumen of an 8 Fr two-lumen catheter. During the sonothrombolysis procedure, the catheter location relative to the thrombus within a blood vessel is monitoring using ultrasound imaging guidance; the catheter tip distance to the blood clot is continuously controlled via a micro linear actuator with a speed of 100 μm/min.}, journal={2021 IEEE 16TH NANOTECHNOLOGY MATERIALS AND DEVICES CONFERENCE (NMDC 2021)}, author={Peng, Chang and Zhang, Bohua and Wu, Huaiyu and Dayton, Paul and Xu, Zhen and Jiang, Xiaoning}, year={2021} }
 @article{peng_chen_jiang_2021, title={Under-Display Ultrasonic Fingerprint Recognition With Finger Vessel Imaging}, volume={21}, ISSN={["1558-1748"]}, DOI={10.1109/JSEN.2021.3051975}, abstractNote={While fingerprint technology has been widely used in mobile devices for user identification, the existing fingerprint sensors can only capture 2D images of the fingerprint and are thus vulnerable to spoofing attacks using 2D replicas of fingerprint. Ultrasonic fingerprint recognition via imaging the structures beneath the human skin can be a promising approach for preventing spoofing attacks on fingerprint-based identification devices. In this study, under-display ultrasonic fingerprint recognition (UDUFR) was investigated for the first time via imaging a finger vessel underneath the fingerprint. A 40 MHz ultrasonic fingerprint sensor composed of PZT-5H piezoelectric active material was firstly developed, which demonstrated broad bandwidth (73.9%) and high loop sensitivity (−27.5 dB) for UDUFR applications. UDUFR experiments were performed to demonstrate the effectiveness of the proposed technique using a two-layer polydimethylsiloxane (PDMS) phantom which consists of a dummy fingerprint in the surface layer and a finger vessel mimicker in the inner layer. Electronic images of the fingerprint and finger vessel with a resolution of $500\times500$ DPI were successfully obtained. The results reported in this study open up new avenues for the next generation of robust and secure UDUFR technology.}, number={6}, journal={IEEE SENSORS JOURNAL}, author={Peng, Chang and Chen, Mengyue and Jiang, Xiaoning}, year={2021}, month={Mar}, pages={7412–7419} }